What you need to know about Nise ointment. Nise gel: instructions, composition, contraindications for use

Nise gel- a synthetic drug used in the treatment of degenerative-destructive changes in cartilage, joint, and bone tissues. The drug quickly reduces the severity of headaches and toothaches, and effectively alleviates a person’s condition after injury. The active ingredient of the external agent is nimesulide belongs to the group of non-steroidal anti-inflammatory drugs (). This is the world's first selective cyclooxygenase inhibitor exhibiting antipyretic and analgesic activity.

Chemical composition and release form

Indian manufacturer Dr. Reddy's Laboratories Ltd. produces 1% Nise gel in plastic tubes of 20 g and 50 g. The secondary packaging of the drug is a cardboard box with an attached annotation. In the Anatomical Therapeutic Chemical (ATC) classification system (ATC) Nise gel is assigned the code M02AA. average price packaging of 20 g is 150 rubles, and 50 g is 250 rubles.

For long-term treatment of any pathologies, it is better to purchase large packaging Nise gel. This will help save money and time spent visiting the pharmacy.

Nise gel is characterized by a jelly-like consistency, light yellow color and the absence of foreign particles. The drug has a pleasant floral scent due to the flavor added by the manufacturer (Narcissus-938). In addition to the active ingredient nimesulide, the product for external use contains the following auxiliary components:

• potassium dihydrogen phosphate;
• N-methyl-2-pyrrolidone;
• distilled water;
• carbomer-940;
• propylene glycol;
• macrogol;
• thiomersal;
• isopropanol;
• butylated hydroxyanisole.

Auxiliary ingredients ensure easy absorption of the active substance into the skin and its delivery to the bone, joint and cartilage tissues affected. The medicine should be stored at room temperature, out of direct sunlight.

pharmachologic effect

The unique combination of active and auxiliary ingredients of Nise gel allows it to be used as a means for complex treatment. Doctors include the drug in therapeutic pathogenetic regimens to prevent further destructive and degenerative destruction of articular and cartilage tissues. And the anti-inflammatory effect of the external agent provides rapid decline symptoms: movements, severe swelling.

The synthesis of Nise gel, the main action of which is aimed at suppressing the activity of cyclooxygenase, made it possible to avoid the occurrence of pronounced side effects from oral administration of PVNP. This medicine is completely safe for patients with elevated blood pressure and mucous membranes of the gastrointestinal tract prone to ulceration.

Pain is the body’s protective reaction to internal and external influences. negative factors. Two mechanisms are involved in its launch:

• local. After development inflammatory process the nerve impulse is transmitted to the central nervous system;
• central. The brain recognizes pain and produces a response to the occurrence of the received signal.

Pain, as a companion to almost all diseases of the musculoskeletal system, is initiated by various substances, excitatory nociceptors (tissue, plasma, tachykinins). Course use of Nise gel allows you to prevent the development of events according to such a negative scenario, reduce the severity discomfort by stopping the inflammatory process.

Pharmacodynamics

The active ingredient of Nise gel belongs to the class of sulfonanilides. The main pharmacological effect of nimesulide is to block the enzyme as a direct participant in the synthesis of prostaglandins from polyunsaturated fatty acids. These biologically active substances transmit nerve impulses from one cell to another and initiate the spread pain syndrome. Increased production of prostaglandins causes the following pathological conditions:

• formation of inflammatory foci;
• formation of edema of varying localization and severity;
• emergence painful sensations.

The active ingredient of Nise gel prevents the production of prostaglandin E2 not only in inflammatory foci, but also in the nociceptor system, which makes innervation in the spinal cord impossible.

One of the main mechanisms of action of the active ingredient of Nise gel is a decrease in the concentration of rapidly converted prostaglandin H2. It is this that prostaglandin isomerase acts on, forming a mediator of pain, swelling and inflammation - prostaglandin E2 - during a complex biochemical reaction.

A gradual decrease in the content of prostaglandins in tissues leads to a decrease in the activity of prostanoid receptors. This condition is characterized by an analgesic and anti-inflammatory effect. An important point all mechanisms of action of Nise gel is the absence of any effect on the formation of prostaglandins from arachidonic acid. This explains the small list of contraindications and side effects with this external medicine.

Nise gel also exhibits pronounced anti-edematous activity immediately after application to the skin due to the ability to trigger the following mechanisms of action:

• suppression of red blood cell aggregation by reducing the synthesis of endoperoxides and thromboxane A2;
• inhibition of the activation of circulating proenzyme by increasing the content of inhibitor-1;
• biological release prevention active substance histamine, which provokes tissue swelling and allergic reactions;
• promotes the formation of lymphocytes produced immune system to destroy foreign proteins.

One of the undoubted advantages of Nise gel is the rapid relief of interleukin-6 and urokinase - the main culprits degenerative changes V cartilage tissues. Nimesulide is involved in the synthesis of elastase and collagenase, which ensure optimal functioning of the human musculoskeletal system.

The active ingredient of Nise gel exhibits powerful antioxidant activity. Nimesulide prevents cell destruction by free radicals and prevents tissue damage from toxic breakdown products of molecular oxygen.

Pharmacokinetics

The active and auxiliary ingredients of Nise gel penetrate into the systemic bloodstream in small quantities. For example, traces of the metabolic product of nimesulide are not detected at all, provided that the patient complies with the recommended single dosages and the duration of the course of treatment. The analgesic effect occurs in approximately 15-30 minutes. With a single use of an external agent in the bloodstream, a maximum therapeutic concentration is created after 24 hours. It is approximately 300 times lower than that determined when taking Nyz orally in tablet form or Nimesulide in granules.

In the process clinical trials The duration of the analgesic effect in patients was established - from 30 minutes to six hours. Reducing the severity of pain had a positive effect on a person’s ability to perform normal daily activities (movement, dressing, toileting, performing light and heavy work) - in 60% of patients after applying 1 g of the product and in 66% after distributing 2 g on the skin drug.

Indications for use

Nise gel is included in the therapeutic regimens of patients diagnosed with various musculoskeletal disorders. A topical medication is used to prevent further destruction of bones, cartilage and joints. The drug is used to relieve the inflammatory process and reduce the severity of pain during exacerbation of chronic diseases of the spinal column. In the treatment of injuries and severe bruises, the use of Nise gel is also practiced to eliminate swelling of soft tissues located near the injuries.

The medicine can be used at home to treat large hematomas (bruises). The active ingredient of the drug helps fast regeneration damaged small blood vessels, restoration of microcirculation and reduction of swelling.

Nise gel is used as a pathogenetic and symptomatic treatment for the following pathologies:

• at the stage of relapse;
• any localization ( , );
• lumbago;
• sciatica;

Instructions for use

Nise gel is well absorbed by the skin due to its delicate consistency. To improve absorption and prevent development bacterial infection The drug should only be applied to clean skin. There should be no damage to it, not even microtrauma (cracks, wounds, scratches). Maximum diffusion of the main ingredients is ensured by the presence of auxiliary components in the gel base.

At simultaneous use Nise gel and tablets, daily and single dosages can vary significantly. When carrying out complex treatment, the amount of the drug for oral administration is reduced by 2-3 times.

It is necessary to apply the medicine only to those areas of the body where pain is felt. The gel cannot be rubbed in - it should only be distributed in a thin layer on the surface of the skin. The annotation states that to ensure an analgesic and anti-inflammatory effect, it is enough to squeeze out a column of the product no more than 3 cm long from the tube. When diagnosing injuries in large areas of the body, the amount of gel can be increased.

The maximum concentration of nimesulide in tissues affected by inflammation is achieved by applying the gel 2-3 times during the day. The duration of the therapeutic course does not exceed 4 weeks. Longer use will cause the accumulation of drug ingredients in tissues, which leads to the development allergic reaction according to the type of urticaria. After applying the drug to the skin, you should wash your hands, since when nimesulide gets into the eyes and mucous membranes, a burning sensation occurs.

After 3-4 weeks of treatment, neurologists or surgeons evaluate the effectiveness of Nise gel. If the therapy does not bring results, or they are minimal, the doctor replaces the drug.

Contraindications and side effects

External preparations with nimesulide in any concentration are not prescribed to patients with recurrent gastrointestinal pathologies of any etiology. The ability of the active substance to prolong and increase bleeding excludes from the list of indications for the use of nimesulide people with stomach and duodenal ulcers, and violations of the integrity of the mucous membranes of the digestive organs. Contraindications to Nise gel include the following pathological conditions:

• acute and chronic renal failure;
• hyperthermia during viral or bacterial respiratory and intestinal infections;
• alcoholism;
• drug addict.

The drug is not included in the therapeutic regimens of women during pregnancy and lactation. Nise gel is not intended for the treatment of children under 12 years of age. Relative contraindications include arterial hypotension, non-insulin dependent diabetes mellitus, acute and chronic heart failure. In the presence of such diseases, the use of external agents is allowed only under constant monitoring of blood composition using laboratory tests.

Side effects after applying Nise gel to the skin usually occur in patients who are intolerant to the active ingredient. Sometimes skin rashes It is not nimesulide that provokes, but the auxiliary components that the manufacturer used as a gel base. Systemic symptoms develop in very rare cases due to minor penetration chemical substances into the bloodstream. What side effects may occur after absorption of the drug into inflammatory foci are described in detail in this table:

Side effects of Nise gel often occur when medical recommendations are ignored, when the patient applies an excessive amount of external product in the hope of get well soon. In any case, if your health worsens, you must stop using the drug and consult a doctor to replace it.

Before using Nise the gel needs to be tested. Not a large number of The product should be applied to the wrist or elbow. If after 30-40 minutes there is no redness or rash on the skin, then you can begin treatment.

Painful sensations, regardless of their origin, cause a lot of inconvenience to a person. The situation is aggravated if the problem is localized in the area of ​​soft tissues and joints. In such cases, the body becomes stiff, and every movement causes pain.

What to do, who to turn to for help, and is it possible to get rid of these symptoms at all? It turns out that the simplest and effective method The solution to the problem is right before your eyes - instructions for using Nise Gel.

Nise gel is a local non-steroidal medicine that helps cope with pain and fever in diseases of various etiologies. It is actively used in the treatment of bursitis, osteoarthritis, tendovaginitis, osteoarthritis, as well as a number of other inflammatory ailments. The drug has become widespread among both doctors and patients.

1. Clinical studies have confirmed that the medication is absolutely safe.
2. A nominal amount of active substances penetrates through the surface of the skin into the main bloodstream.
3. The maximum concentration in the body is formed only 24 hours after using the gel.
4. The drug composition does not affect chemical composition blood plasma.

The medication does not accumulate in tissues, joints or internal organs, and is completely excreted through the liver.

Pharmacological group and action

Nise ointment belongs to the big pharmacological group non-steroidal anti-inflammatory drugs (sulfonanilide class) local action(NSAIDs). After application to the problem area of ​​the body, it eliminates inflammatory processes in the joints, soft tissues, relieves painful symptoms. The main active ingredient of the drug is nimesulide, which causes a therapeutic, analgesic effect.

• Prevents the synthesis of prostaglandin at the site of the inflammatory process (without this element the formation of edema and painful sensations is impossible).
• Inhibits COX, acting selectively on problem areas. In rare cases, it affects healthy cells.
• Menthol in the composition of the medication helps to activate cold receptors, resulting in a calming effect.
• Joint and bone tissue are nourished in the form of calcium ions, thanks to which the affected area is quickly saturated with nutrients and oxygen.

Methyl salicylate increases the intensity of blood flow at the site of application (after hydrolysis), suppresses biochemical processes associated with the formation of edema and severe pain (including lipid oxidation). Due to which there is a local anti-inflammatory and analgesic effect, the amplitude and range of movements gradually increases

Release form and composition

The pharmaceutical drug is available in the form of a white translucent gel (for some manufacturers the color is shifted towards yellow tones). It is a homogeneous, medium-thick consistency without any foreign inclusions or substances. Available for sale in aluminum tubes of 20 and 50 g. Supplied in a separate cardboard box with annotation.

A number of excipients are also present: thimerosal, macrogol, isopropanol, carbomer 940, propylene glycol.

Storage conditions and shelf life of the drug

The gel is prescribed to be stored in a dark place at a temperature of 24 °C; it is important to avoid contact of the aluminum tube with direct sunlight and sources of moisture. When placed in the refrigerator and frozen, the drug loses its declared properties.

The shelf life in a sealed tube, subject to the above requirements, is 24 months from the date of manufacture indicated on the cardboard box. If the tube is damaged, the thickness of the consistency, color changes, or a pronounced odor appears, use of the medicine is strictly prohibited!

Instructions for use

Use a pharmaceutical drug for treatment joint pain necessary as prescribed by a doctor. When using the composition yourself, it is important to read in detail the instructions for applying the Nise gel. To achieve the desired effect, it is recommended to strictly adhere to the indicated dosage and frequency of procedures.

There is only one method of use for the drug - external, local.

1. The area where the gel is applied is washed with soap and water, if possible treated with an antiseptic, and wiped dry with a towel.
2. The medicinal composition is applied only to “clean” skin, without inflammation, damage or ulcers.
3. The recommended amount of gel for application to the surface of the skin is up to 3 cm (3 g) for 1 procedure.
4. Medium thickness consistency evenly distributed over problem area, forming thin layer coverings. Healthy skin not processed!
5. It is forbidden to rub the drug into the epithelium; the absorption process occurs naturally without outside intervention.
6. An anti-inflammatory, antipyretic agent is applied 1-3 times a day (every 8-12 hours), every day (no more than 10 days).

After applying the medication to the surface of the skin, it may cause itching and burning. It stops without patient intervention after 2-4 minutes. The duration of treatment is determined by the doctor, based on the characteristics of the pathology and accompanying symptoms.

Indications for use

A feature of the Nise gel is its wide spectrum of action. It is used to combat ailments musculoskeletal system, relief of painful sensations that develop against the background of increased body temperature.

Nise ointment is often prescribed for bruises, injuries, bruises, inflammations localized in cartilage and bone tissue.

Contraindications and side effects

There is none pharmaceutical drug, which would have no contraindications. Nise gel also has restrictions on its use.

• open wounds, active inflammatory processes accompanied by purulent discharge;
• severe renal failure;
• high sensitivity to active or auxiliary substances;
• internal bleeding localized in the stomach area;
• extensive lesions digestive tract ulcers;
• problems with blood formation;
• children under 7 years of age.

Elderly patients diagnosed with hypertension, diabetes mellitus (type 2), and pathologies of the cardiovascular system should exercise extreme caution when applying the medicine.

Overdose is often accompanied by side effects (despite the lack of officially confirmed data):

• migraine attacks;
• erosive formations on the gastric mucosa;
• nausea followed by vomiting;
• burning;
• problems with blood formation;
• severe allergic reactions;
• local swelling;
• dizziness.

If after taking the medication the patient experiences an unpleasant sensation or one of the side effects, the subsequent use of the medication should be discontinued. It is equally important to seek medical help promptly.

Use during pregnancy and lactation

Pregnant women are strictly prohibited from applying Nise Gel. To prevent joint pain, substitutes or analogues are used as prescribed by a doctor. Similar restrictions are imposed during lactation. If there is an urgent need to use the particular composition in question, breastfeeding is stopped until the end of the therapeutic course.

Interaction with other drugs

Nise gel is used with extreme caution if the patient has already been prescribed the following drugs: lithium-containing drugs, NSAIDs, digoxin, phenytoin, cyclosporine, hypoglycemic and antihypertensive drugs. Required in mandatory notify the attending physician (if there are several, consult with each).

Directions for use and doses

Nise cream, in accordance with the instructions, is used exclusively externally. The safe dose when applying the composition is a strip 2.5-3 cm long. For children - 1.5-2 cm. Use the composition 3 to 4 times a day (children - 1 to 3 times). Treatment is limited in time to 10 days. If there is no positive dynamics within 7 days, it is recommended to consult a doctor to adjust the therapeutic course.

special instructions

Nise ointment is applied only to clean and intact skin. It is important to avoid contact of the drug with open wounds and mucous membranes. It is strictly forbidden to take the medication orally.

1. The gel is not intended for children under 7 years of age.
2. Applying sealed and tight bandages with the medication in question is taboo.
3. After applying the thick consistency to the problem area, screw the tube cap tightly.
4. Before and after the procedure, hands are thoroughly washed with antibacterial soap.

It is safest to fight the disease under the supervision of a specialist. A personal treatment and therapy regimen must be prepared for each patient.

Instructions

Nise gel is a medicine that has a local anesthetic effect. The drug has contraindications and side effects Therefore, it should be used as prescribed by a doctor.

Nise gel is a medicine that has a local anesthetic effect.

Compound

1 g of gel contains:

• active ingredient - nimesulide (10 mg);
• propylene glycol;
• isopranol;
• potassium phosphate;
• distilled water;
• carbomer;
• flavoring

Pharmacological group

Mechanism of action

Pharmacodynamics

The drug has the following pharmacological properties:

1. Reduces the activity of type 2 cyclooxygenase, which is involved in the synthesis of prostaglandins. The drug prevents the accumulation of inflammatory mediators in the affected areas and nearby nerve endings.
2. Reduces the speed of pain impulses in the spinal cord.
3. Suppresses the activity of prostanoid receptors. This effect is explained by a decrease in the amount of prostaglandin E2. The drug has analgesic and anti-inflammatory effects.
4. Helps reduce the intensity or completely eliminate pain in areas of inflammation when applied externally. Relieves the feeling of stiffness, restores joint mobility, eliminates swelling.

Pharmacokinetics

When applied to small areas of the skin, nimesulide is absorbed into the blood slowly, it practically does not accumulate in the body.

What does Nise gel help with?

The drug is used for:

• inflammatory and degenerative changes in joints (arthritis and arthrosis);
• psoriatic lesions of the musculoskeletal system;
• Bekhterev's disease;
• gouty arthritis during exacerbation;
• sprains and inflammation of ligaments and tendons;
• osteochondrosis accompanied by radicular syndrome;
• sciatica and radiculitis;
• rheumatic lesions of soft tissues;
• rheumatoid arthritis;
• post-traumatic pain syndrome (after bruises, ligament ruptures and bone fractures).

Contraindications

Nise is not used for:

• individual intolerance to nimesulide and auxiliary ingredients of the gel;
• exacerbation of peptic ulcer of the stomach and duodenum;
• gastrointestinal bleeding;
• the presence of wounds, ulcers and cracks in the skin of the affected areas;
• bacterial, viral and fungal skin infections;
• dermatitis and dermatoses;
• bronchospasm that occurs when using non-steroidal anti-inflammatory drugs;
• decompensated diabetes mellitus;
• hypertensive crisis;
• acute heart failure.

How to apply Nise gel?

The gel is applied to intact areas of the skin located above the inflammatory focus. Before using the drug, the skin is washed and dried with a towel. 1-2 g of gel are evenly distributed over the area of ​​maximum pain. There is no need to rub the drug in. The procedure is repeated 3-4 times a day. The amount of gel used and the frequency of application depend on the area of ​​the affected area and intensity discomfort. It is not recommended to be treated for more than 10 days without medical supervision.

For bruises

Before using Nise-gel for bruises, apply cold compress, which reduces swelling and prevents the spread of hematoma. After applying the drug, the joint is fixed with a tight bandage and the injured limb is provided with rest.

For pain

For osteochondrosis

Before using the ointment, it is recommended to take a warm bath, which will facilitate the penetration of nimesulide into the site of inflammation. 2-3 g of the product is applied to the skin, rubbing in a circular motion. The back is covered with a woolen scarf. The procedures are carried out in the morning and evening.

Can the gel be used for children?

Nise is contraindicated for children under 7 years of age. When treating older patients, use caution.

Does Nise gel cause side effects?

When using Nise Gel, the following may occur:

• itching and burning of the skin;
• increased temperature in affected areas;
• transient redness of the skin that does not require cessation of treatment.

Treatment of large areas of skin may result in:

• nausea and vomiting;
• loose stools;
• swelling of the face and lower extremities;
• increased levels of ALT and AST;
• dizziness;
• blood in urine;
• signs of dysfunction of the hematopoietic system (decrease in the number of platelets, granulocytes and leukocytes);
• bleeding disorders;
• skin rashes like urticaria.

Overdose

There have been no cases of acute overdose of Nise gel. A single application of more than 50 g increases side effects. Treatment in this case is symptomatic.

Features of application

During pregnancy and lactation

The safety of the drug for the fetus and breastfed child has not been proven, therefore the gel is not recommended for use during pregnancy and lactation.

For impaired renal function

For liver dysfunction

Persons with severe liver failure, Nise is prescribed only for severe pain.

Drug interactions

With other drugs

It is not recommended to use Nise in combination with cardiac glycosides, lithium preparations, Cyclosporine, immunosuppressants and diuretics. The drug enhances the effectiveness of other NSAIDs. Nimesulide may suppress the effect of hypoglycemic and antihypertensive drugs.

Alcohol compatibility

Storage conditions and periods

The drug is kept in a dry, cool place, avoiding freezing. Shelf life is 24 months from the date of issue.

Conditions for dispensing from pharmacies

Is it sold without a prescription?

What is the price?

50 g of gel will cost 300-350 rubles.

Nise (tablets, gel, suspension) – instructions for use, analogues, reviews, price

Thank you

Nise is a non-narcotic anesthetic And antipyretic drug from the group of non-steroidal anti-inflammatory drugs (NSAIDs). Nise is used as a symptomatic drug in the composition complex therapy at various states and diseases accompanied by elevated body temperature, pain and inflammation. The main areas of application of Nise are the treatment of osteoarthritis and osteoarthritis, as well as pain relief of various etiologies and localization (for example, injuries, toothache, menstrual pain, diseases of the ear, throat, nose, etc.) and a decrease in body temperature during infections.

Names, varieties and forms of release

• Tablets for oral administration;
• Dispersible tablets (soluble in a small amount of water) for oral administration;
• Suspension for oral administration;
• Gel for external use.

Tablets for oral administration are simply called tablets or "Nise 100", and various terms are often used to refer to the suspension, such as syrup, solution and others, which are united by the fact that they imply a liquid dosage form intended for oral administration. The suspension is also called “Nise for children”, since this particular form of the drug is approved for use in children from 2 years of age. Dispersible tablets are sometimes called soluble tablets because they are intended to be taken orally after first dissolving in a small amount of water. These tablets differ from the usual ones in a lower dosage of the active substance, as well as minimal risk irritation of the gastric mucosa.

Gel for external use is often mistakenly called ointment. However, since Nise in this dosage form is not available, when people say “Nise ointment,” they mean the gel.

Nise - composition

• Tablets for oral administration – 100 mg of nimesulide per tablet;
• Dispersible tablets – 50 mg of nimesulide per tablet;
• Suspension – 50 mg of nimesulide per 5 ml of solution;
• Gel – 1% (10 mg nimesulide per 1 g).

Therapeutic effect

• Analgesic effect (analgesic);
• Antipyretic effect (reduces body temperature);
• Anti-inflammatory effect.

Nise, by blocking the work of cyclooxygenase, prevents the formation of leukotrienes and prostaglandins, which, in turn, stops the active course of the inflammatory process. Since the inflammatory process is minimized, the pain, heat, swelling and redness associated with it are relieved. The functioning of the affected organ is also facilitated.

Since Nise has nonspecific action, he is capable of providing therapeutic effect during the inflammatory process, regardless of the location and nature of the cause that caused it. That is why Nise is able to relieve pain during menstruation, joint diseases, injuries, neuralgia, headaches, toothaches, etc. Also, the drug perfectly reduces body temperature during a viral or bacterial infection, and also reduces the severity of any inflammatory process, regardless of what exactly it is caused by (for example, infection, autoimmune disease, injury, etc.).

In terms of the severity of the anti-inflammatory effect, Nise is superior to Indomethacin, Diclofenac, Ibuprofen and Piroxicam. The analgesic effect of Nise is the same as that of Ibuprofen, but less pronounced compared to Indomethacin. The antipyretic effect of Nise is more powerful than that of Indomethacin, Ibuprofen, Aspirin and Paracetamol.

Since Nise can exert its effects locally and systemically, it is used in various dosage forms depending on the location of the inflammatory process and pain. For example, when pain and inflammation are localized in internal organs and mucous membranes, it is necessary to take Nise orally so that the drug can reach all affected cells and tissues through the bloodstream. And if the pain is localized in the muscles or skin, you can not take Nise orally, but apply it externally, directly to the affected area, so that the active substances penetrate to the source of inflammation through the skin structures. Often for reinforcement therapeutic effect the drug is simultaneously taken orally and applied externally, especially when chronic diseases joints.

In addition to the antipyretic, anti-inflammatory and analgesic effects, Nise has a number of other, less significant and less pronounced effects. Thus, the drug reduces the ability of platelets to stick together (aggregate) and form blood clots by suppressing platelet activity factor.

Nise - indications for use

Tablets, dispersible tablets and Nise suspension

• Rheumatoid arthritis;
• Joint damage due to rheumatism;
• Periods of exacerbation of gout;
• Psoriatic arthritis;
• Ankylosing spondylitis;
• Osteochondrosis;
• Radiculitis;
• Sciatica;
• Lumbago;
• Osteoarthritis;
• Arthritis of any cause;
• Joint pain (arthralgia);
• Muscle pain (myalgia);
• Inflammation of ligaments and tendons (tendinitis, tendovaginitis, etc.);
• Bursitis;
• Traumatic inflammation of the soft tissues of the musculoskeletal system (for example, after bruises, ruptures and sprains, etc.);
• Pain of various origins and localization (menstrual, dental, joint, headache, pain after surgery, with gynecological and ENT diseases, etc.);
• Increased body temperature of any origin.

• Increased body temperature due to any disease, including after vaccination;
• Inflammatory process of the ENT organs and respiratory tract during viral or bacterial infections;
• Relief of pain after operations, injuries, soft tissue injuries, etc.

Nise gel (ointment)

• Inflammatory or degenerative diseases of bones, joints, ligaments, muscles and tendons, such as gout, rheumatism, arthritis, osteoarthritis, osteochondrosis, radiculitis, lumbago, bursitis, tendinitis, sciatica, etc.;
• Muscle pain of any origin;
• Traumatic inflammation of the musculoskeletal system (for example, bruises, tears or sprains of muscles, ligaments, etc.).

Instructions for use

Nise tablets - instructions for use

Nise tablets can be given to children from 12 years of age.

Nise is given to children over 12 years of age in the same dosages as adults. Elderly people over the age of 65 should also take Nise in standard, unreduced dosages. In case of renal failure with creatinine clearance determined by the Rehberg test of at least 30 ml/min, there is also no need to reduce the dosage of the drug. If creatinine clearance is below 30 ml/min, then Nise cannot be used in any dosage.

To relieve pain, relieve fever or reduce the severity of inflammation, it is recommended to take Nise 1 tablet (100 mg) twice a day. It is advisable to take the tablets at regular intervals, for example every 12 hours. If necessary, you can increase the number of tablets to 4 tablets per day, which can be taken at intervals of at least 6 hours. Maximum permissible daily dosage Nise is 400 mg, exceeding which can cause an overdose.

The duration of taking Nise is determined by the speed of healing and reduction in the severity of painful symptoms. That is, in every specific case The duration of the course of therapy is determined individually and can range from several days to several weeks.

Instructions for use of Nise dispersible tablets

Before taking, one tablet is dissolved in a teaspoon of water. If you need to take two tablets at once, it is optimal to dissolve them both in a tablespoon of water. In general, to calculate the required amount of water, you can use the following ratio - one tablet per 5 ml of water (1 teaspoon).

Dissolved tablets are taken without additional water or any other drinks. If a person has a desire to wash away the feeling and taste of tablets from the oral mucosa, then they can take a large sip of clean water.

Dispersible tablets can be given to children from three years of age.

To relieve pain, fever and inflammation during various diseases Adults and adolescents over 12 years of age should take Nise 100 mg (2 dispersible tablets) twice daily. If necessary, you can increase the frequency of taking tablets up to 4 times a day, keeping at least 6-hour intervals between them. The maximum permissible daily dosage of Nise for adults and children over 12 years of age is 400 mg.

In elderly people over 65 years of age and with renal failure with a creatinine clearance of at least 30 ml/min, Nise is used in normal dosages, which do not need to be reduced. In case of renal failure with creatinine clearance below 30 ml/min, Nise cannot be used in principle.

For children aged 3 – 12 years, the daily dosage of Nise is calculated individually according to body weight, based on the ratio of 3 – 5 mg per 1 kg of weight. For example, a child weighing 20 kg should take Nise at a dosage of 3 * 20 = 60 mg and 5 * 20 = 120 mg, that is, 60 – 120 mg per day. The daily dosage calculated in this way is divided into 2 - 3 equal parts for administration 2 - 3 times a day at approximately equal intervals. The maximum permissible daily dosage of Nise is 5 mg per 1 kg of child’s body weight. If the child’s weight is more than 40 kg, but he is under 12 years old, then he is given Nise in adult dosage 100 mg twice a day.

The duration of use of Nise is determined individually depending on the speed of disappearance of symptoms.

Instructions for use of Nise suspension

Before use, shake the bottle with the suspension so that its contents become homogeneous, then pour required amount into a measuring cup or syringe and drink. If necessary, you can wash down the suspension with a small amount of water.
Nise in the form of a suspension can be used for children from two months in the following dosages:

• Children aged 2 months - 2 years - the dosage of the suspension is calculated individually according to body weight, based on the ratio of 1.5 mg per 1 kg of weight. That is, a child weighing 10 kg needs 1.5 * 10 = 15 mg of Nise per day. Calculated daily amount The drug is divided into 2 - 3 equal parts and given to the child 2 - 3 times a day. In our example, 15 mg/3 = 5 mg, that is, the child needs to be given a Nise suspension of 5 mg (which corresponds to 0.5 ml or 13 drops) three times a day;
• Children aged 2 – 5 years – take 2.5 ml of suspension 2 – 3 times a day;
• Children 5 – 12 years old – take 5 ml of suspension 2 – 3 times a day;
• Children over 12 years old - take the drug in an adult dosage in any dosage form, that is, 100 mg 2 times a day, which corresponds to 10 ml of suspension, 1 regular tablet or 2 dispersible tablets.

The duration of taking Nise suspension is different and depends on the speed of normalization of the person’s condition and the disappearance of symptoms. At acute conditions It is recommended to use Nise for no more than 5 – 10 days.

Gel (ointment) Nise - instructions for use

For a one-time application, squeeze out approximately 3 cm of gel from the tube and, without rubbing, distribute it evenly over the affected surface. Then leave for 1 - 2 minutes so that the composition is absorbed into the skin. After this, you can apply regular gauze bandage or leave it uncovered. Airtight dressings should not be applied over the gel.

The gel is applied to the skin 3 – 4 times a day. It is not recommended to apply the gel more than 4 times a day, as this may cause the development of side effects. The maximum allowable amount of gel that can be used during the day is 30 g, which corresponds to 1.5 tubes of 20 g.

The duration of use of the gel is determined individually depending on the rate of disappearance unpleasant symptoms. It is not recommended to use Nise gel for more than 10 days in a row without consulting a doctor.

When rubbing the gel into the surface of the skin, a burn may occur, which will go away on its own within a few days. If irritation appears in the area where the gel is applied, you should stop using Nise.

Capsaicin, which is part of the gel, can provoke a burning sensation and redness of the skin in the area of ​​application. In rare cases, the burning sensation does not disappear, but turns into increased sensitivity of this area of ​​the skin. These effects are a normal skin reaction to the gel and do not require discontinuation of the drug.

When using the gel, it is necessary to avoid contact with the eyes, as well as the mucous membranes of the nose, oral cavity and other organs. After using the drug, close the tube tightly and wash your hands with soap.

special instructions

Nise should also be used with caution by people suffering from cardiovascular diseases, dehydration, asthenia, metabolic disorders and diseases of the digestive tract.

Since Nise can reduce blood clotting, it should be used with caution by people prone to bleeding, taking anticoagulants and suffering from hemorrhagic diathesis. If these conditions are present, blood clotting parameters (platelet count, fibrinogen, APTT, PTI, INR, TV, etc.) should be monitored during the entire course of using Nise.

In order to reduce the risk of side effects, it is necessary to use Nise in the minimum effective dosage. If a person’s condition does not improve within 2–3 days while using Nise, then you should stop taking the drug and consult a doctor.

If, while taking Nise tablets or suspension, a person experiences nausea, anorexia, vomiting, abdominal pain, dark urine, yellowing of the skin, increased activity AST and ALT, as well as fatigue, you should immediately stop using the drug and consult a doctor, since these symptoms indicate the development of liver damage. In the future, a person who experiences similar symptoms should not use Nise or any other medications containing nimesulide.

Impact on the ability to operate machinery

Overdose

• Apathy;
• Drowsiness;
• Nausea;
• Increased pressure;
• Impaired kidney function (swelling, urinary retention, increased concentration of urea, creatinine in the blood, etc.);
• Irritation of the digestive tract;
• Gastrointestinal bleeding;
• Respiratory depression;

Interaction with other drugs

Nise for children

• Children under 3 years old - only Nise suspension can be given;
• Children 3 – 12 years old – you can give dispersible tablets or Nise suspension;
• Children over 12 years old - Nise can be given in any form.

• Children aged 2 months - 2 years - the dosage of the suspension is calculated individually according to body weight, based on the ratio of 1.5 mg per 1 kg of weight. The calculated daily amount of the drug is divided into 2 - 3 equal parts and given to the child 2 - 3 times a day;
• Children aged 2 – 5 years – take 2.5 ml of suspension 2 – 3 times a day. The dosage of dispersible tablets is calculated individually according to the ratio of 3 – 5 mg per 1 kg of weight;
• Children 5 – 12 years old – take 5 ml of suspension or 1 dispersible tablet 2 – 3 times a day;
• Children over 12 years old - take the drug in an adult dosage in any dosage form, that is, 100 mg (10 ml suspension, 1 regular tablet or 2 dispersible tablets) 2 times a day.

Use during pregnancy and breastfeeding

Nise for pain, including dental

Nise by temperature

Alcohol compatibility

Side effects of Nise

• Skin rash ;
• Bronchospasm;

• Dizziness;
• Feeling of fear;
• Nightmares;
• Drowsiness;
• Reye's syndrome.

• Rash;
• Dermatitis;
• Hives;
• Swelling;
• Exudative erythema multiforme;
• Lyell's syndrome;
• Stevens-Johnson syndrome.

• Edema;
• Urinary retention;
• Increased potassium concentration in the blood;
• Kidney failure;
• Decreased amount of urine;
• Interstitial nephritis.

• Nausea;
• Vomit;
• Abdominal pain;
• Tarry stools;
• Bleeding from the gastrointestinal tract;
• Stomach or intestinal ulcer.

• Increased activity of AST and ALT;
• Hepatitis;

Nise gel is a drug that belongs to the group of anti-inflammatory non-steroidal drugs For local application and is used in the treatment of osteoarthritis, osteoarthritis, bursitis, tendovaginitis and other inflammatory joint diseases.

Release form and composition

The drug is produced in the form of a gel for topical use of 1% in laminated aluminum tubes of 50 or 20 grams, packaged in cardboard packs. It has a transparent, light yellow or yellow color and is free from foreign particles.

One gram of the drug “Nise Gel” contains ten milligrams of the active substance nimesulide.

Auxiliary components include propylene glycol, isopropanol, N-methyl-2-pyrrolidone, macrogol, butylhydroscianisole, carbomer 940, potassium phosphate, thimerosal, flavoring.

Beneficial features

The drug "Nise Gel" has anti-inflammatory, antipyretic, antiplatelet and analgesic effects. It suppresses the formation of prostaglandins in areas of inflammation and selectively inhibits type 2 cyclooxygenase.

The drug rarely has side effects due to inhibition of prostaglandin synthesis in healthy tissues. It slows down the processes of lipid peroxidation and their metabolites and does not affect hemostasis and phagocytosis.

When taken orally, the drug can be well absorbed directly from the stomach and intestines. Maximum indicator drug concentration is reached 1.5-2.5 hours after administration. Its half-life reaches three hours.

The main metabolite in the drug is the active hydroxynimesulide. This drug undergoes biotransformation processes in the liver. It is excreted primarily by the kidneys. With prolonged use it is not able to accumulate.

In the form of a gel, the drug has a local analgesic and anti-inflammatory effect. With its help, pain in the joints disappears or is weakened at rest and in a state of movement. Morning joint stiffness and swelling are neutralized as a result.

Indications for use

The drug "Nise gel" is prescribed for the following diseases:

• osteoarthritis,
• tendovaginitis,
• ankylosing spondylitis,
• post-traumatic pain,
• muscle pain,
• spinal pain,
• various infectious diseases,
• neuralgia,
• myalgia,
• febrile syndrome.

In the form of a gel, the drug is used to eliminate inflammatory and degenerative diseases of the musculoskeletal system, such as articular syndrome with exacerbation of rheumatism and gout, psoriatic and rheumatoid arthritis, osteochondrosis with the presence of radicular syndrome, radiculitis, sciatica, bursitis, lumbago, osteoarthritis, inflammatory lesions ligaments, tendons.

Instructions for use

The drug in the form of a gel must be applied directly to the skin. Before this the necessary area skin You need to wash it thoroughly and then dry it as well.

A column of gel, the length of which is three centimeters, is applied to the most painful area, then rubbed to a uniform thin layer. This procedure can be carried out three to four times a day. The medicine can be used for ten days.

Contraindications

The drug "Nise Gel" is contraindicated in the presence of gastric ulcer directly in the acute stage, hypersensitivity to one or more of its components, insufficiency of liver function, "aspirin" asthma, and insufficiency of renal function.

It is also not recommended to use the drug for type 2 diabetes mellitus, congestive heart failure, during lactation, pregnancy, arterial hypertension. Children under the age of twelve are not recommended to use this drug, and for children under two years of age it is prohibited in any form.

For using the drug "Nise gel" there are also additional contraindications: dermatoses, damage to the epidermis, various infectious processes, localized in the area of ​​its application.

Side effects

The use of this medicine may be accompanied by the following side effects: drowsiness, headache, nausea, dizziness, vomiting, heartburn, diarrhea, stomach pain, tarry stools, toxic hepatitis, ulceration of the intestinal and gastric mucosa, melena, petechiae, purpura, oliguria, anemia, fluid retention, thrombocytopenia, leukopenia, hematuria, agranulocytosis, high activity of liver “transaminases”.

May also be noted various reactions allergic type, such as skin rash and anaphylactic shock.

The use of the gel may also cause local adverse reactions: peeling skin, itching, urticaria. Sometimes there is a transient change in the color of the skin; in this case, the drug does not need to be discontinued. If it is applied to large areas of the skin, systemic side effects may develop.

If side effects develop, you must stop using the gel and seek help from a specialist.

Price

The price for the drug “Nise Gel” varies in Russian pharmacies depending on the manufacturer and the amount of product in the tube (20 or 50 grams). On average, it ranges from 120 rubles to 266 rubles. The main country producing this drug is India.

In Ukraine, the lower price threshold for the drug “Nise Gel” is 20.50 hryvnia. The highest price reaches 215 hryvnia (the tube contains 50 grams of the medicine).

Analogs

The drug "Nise Gel" has a fairly large number of analogues. For example, almost the same active ingredients available in medicines"Sulaidin" and "Nimesulide". They have a similar mechanism of action and basically do not differ in dosage, indications, contraindications and features of use.

The following drugs belong to the same group, but have a slightly different composition: “Artrum gel”, “Bioran gel”, “Diclofenac”, “Voltaren”, “Fastum”, “Orthoflex” ointment. It is worth noting that before using them you should seek help from a specialist, since there are certain contraindications and features of administration.