Ointment Ketoprofen: instructions for use. Ketoprofen gel: instructions for use and features of the action of a non-steroidal drug, a review of analogues and reviews

Ketoprofen is a pharmacological non-steroidal drug, the main purpose of which is the treatment of arthritis and the removal pain. Additional benefits drug are properties such as antipyretic and anti-inflammatory effect. Withdrawal pain symptoms occurs by blocking the production of prostaglandins.

Properties and form of release of the drug

Ketoprofen allows you to have the following positive effects on the body:

eliminates the development of the process of gluing platelets;
relieves fever symptoms;
eliminates signs of joint stiffness;
eliminates the development of inflammatory processes;
reduces pain in the joints;
allows you to remove puffiness and swelling;
greatly facilitates movement.

The main active ingredient of the drug is the substance ketoprofen. The composition of the drug includes other Excipients, which depends directly on the form of release. The drug is produced in the following forms:

Tablets that have two types of dosages of 100 and 150 mg.
Injection.
Gels that are intended for external use.
Rectal suppositories.

The composition of the solution for injection includes the following components:

Ludipress;
Povidone K30;
Crospovidone;
Silica;
magnesium stearate.

The basis of this medicinal product is the substance ketoprofen, which is contained in 1 capsule in the amount of 100 mg.

The main types of indications for the use of the drug

The main indication for the use of Ketoprofen is the need for long-term therapy to eliminate a disease such as chronic form inflammatory arthritis. The disadvantage of the drug can be called the fact that the drug acts directly on the symptoms, but does not affect the causes of the development of pain. Ketoprofen is used when available inflammatory signs in the joints, as well as in infectious and allergic diseases.

The instructions for use of the Ketoprofen medication in the form of injections also indicate that it can be used not only for chronic diseases, but also for the development of acute pain, the causes of which may be inflammation of the joints and back diseases. The tablet form of the drug is used mainly for long-term therapeutic treatment.

Ketoprofen in the form of a gel is used exclusively for external use, through which it is possible to relieve or reduce pain in case of minor injuries, sprains, torn ligaments, and bruises. The main types of diseases in which the use of Ketoprofen is indicated are the following ailments:

arthrosis;
Arthritis;
Rheumatism;
Psoriatic types of arthritis;
Chronic inflammation of the joints;
Bruises and injuries of the joints;
Radiculitis;
Pain in the lumbar region;
Ligament and tissue injuries;
Neuralgia;
Otitis;
Bursitis;
Spondyloarthritis;
Tendinitis.

Depending on the developing symptoms, a more acceptable form of release of Ketoprofen is prescribed. Injections for intramuscular or intravenous administration are used to relieve acute pain in the joints, and tablets are used to relieve chronic pain.

Application methods

Ketoprofen solution is intended for intramuscular and intravenous use. Intravenously, the medicine is administered directly with the help of a dropper and only in a hospital setting. Putting a dropper at home is permissible only in the presence of medical staff. Solution for intramuscular injection it is allowed to perform at home on your own, but only after the appointment of a doctor. It is permissible to put no more than 2 injections per day.

Intravenous administration of Ketoprofen solution is carried out using a dropper. The process looks like this:

To begin with, the drug Ketoprofen in the amount of 1-2 ampoules should be mixed with a solution of sodium chloride.
It will take about 100-200 ml of saline, after which the nurse puts a dropper on the patient for 30-60 minutes, depending on the dosage.
It is allowed to administer the medicine again no earlier than 8 hours from the moment when the last dropper ended.

You can also administer the drug intravenously in another way, which is called continuous infusion. Represents such an injection method the following actions:

Combine 2 ampoules of Ketoprofen with 500 ml of one of these types of solvents: Ringer's solution, dextrose solution and 0.9% infusion solution.
The resulting solution is administered intravenously for 8 hours. The patient during the introduction can sleep.
Repeated use of the drug is allowed no earlier than after 8 hours.

Jet administration of Ketoprofen intravenously is prohibited. The solution can also be used for intramuscular injection. An injection is made at the same time in such parts of the body as the gluteal muscle, shoulder muscle or elbow of the hand. Solution for injection intramuscular application can be used no more than 2 times a day. Quantity limit allowable dose with one intramuscular injection is 100 mg or one ampoule. It is forbidden to administer the drug in an amount of more than 200 mg per day. Injections are injected into the muscle area deeply, which allows you to accelerate the effect. The course of intramuscular use should not exceed 2 days. If there is a need for a longer course of treatment, then the drug is used orally or rectally.

It's important to know! The drug is very sensitive to light, so it should be stored only in dark places.

It is important to note that Ketoprofen can be mixed with various types medicines, which will not only eliminate the symptoms of the disease, but also achieve a better therapeutic effect. Drugs with which Ketoprofen can be used:

morphine;
general analgesics.

Mixing two drugs is allowed only after the testimony of a doctor. After pain relief, you can stop taking the drug, after agreeing with your doctor.

After intramuscular or intravenous use the effect of the drug occurs after 20-30 minutes. After the solution has been ingested, its composition does not accumulate in the body, therefore, after 8 hours, it is completely excreted from the body. The drug is quickly absorbed by the liver, and the remains of the drug are excreted through the genitourinary organs.

How to use Ketoprofen gel

The instructions indicate that the gel is allowed to be used exclusively externally. It is necessary to apply the gel on the skin in the area of \u200b\u200bthe focus of pain symptoms. The gel is applied in small quantities, which is important to consider when using it.

After the gel is applied to the skin, it should be thoroughly rubbed. You can use the product in the form of a gel no more than 2-3 times a day. Children aged 6 to 12 can use this tool in an amount not more than 2 times a day and in small quantities. The course of treatment is 14 days, but no more. The possibility of using Ketoprofen gel should be checked with your doctor.

Instructions for use of Ketoprofen tablets

The drug Ketoprofen in the form of tablets is used to reduce the manifestation of signs of diseases that are chronic. One capsule of the drug contains 50 mg of the active ingredient ketoprofen. For each patient, the dosage is individual and depends on such factors as the characteristics and signs of the disease, the severity of the disease, the age of the patient. The initial dosage of the drug does not exceed 300 mg per day, which should be divided into 3 single use for one day. This means that 2 tablets should be taken per dose. Tablets are taken orally during a meal, after which they should be washed down with water.

Presence of contraindications

The drug has a number of contraindications, in the presence of which the patient is prohibited from prescribing it. These contraindications include:

intolerance to the composition of the drug, against which there may be signs of allergies;
bronchitis;
gastritis;
low blood clotting;
ulcer in the acute stage;
liver function problems;
breastfeeding period;
pregnancy, especially you should refrain from using the medication in the first and third trimester.

In the presence of any of the above drugs other drug options should be preferred. If the doctor has prescribed Ketoprofen, and you know that you have a disease that is a contraindication, then you should inform the doctor about this. If this is not done, then the consequences will not be the most predictable. Ketoprofen is contraindicated in the form of injections for intravenous and intramuscular use in children under 14 years of age.

Can it be used during pregnancy

Studies on the safety of the drug in such a delicate period as pregnancy have not been conducted. It follows from this that in order to avoid the development of unpredictable consequences, it is required to exclude the use of the drug. Only in case of vital necessity, the drug can be prescribed to a pregnant woman in the second trimester of pregnancy, but as directed by a doctor. During the first and third trimester, the use of the drug may lead to lethal outcome for the fetus.

Development of adverse symptoms

It should be noted that in addition to providing therapeutic effect, Ketoprofen medication can cause side symptoms, which is due to improper use or the presence of contraindications. Side effects occur mostly rarely, but still their development is not excluded.

Gastrointestinal: pain in the abdomen, indigestion, exacerbation of ulcers, development of bleeding.
Nervous system: dizziness, sleep disturbance, drowsiness, nervousness, hallucinations.
Cardiovascular system: increased heart rate and development of hypertension.
Allergic symptoms are manifested by the appearance of a skin rash, hives, runny nose, bronchospasm. May occur anaphylactic shock if the patient has serious symptoms drug intolerance.
Developing excessive sweating, nose bleed, shortness of breath and general malaise.

With the development adverse symptoms you should immediately stop the course of therapy, and see your doctor.

Interaction with other drugs

It was noted above that Ketoprofen can be used with most various drugs. It is important to note that in no case should the drug be mixed and used in conjunction with Tramadol. The consequences can be simply fatal.

At simultaneous application Ketoprofen with drugs for the treatment of kidneys, the effectiveness of the latter is significantly reduced. The use of the drug with anticoagulants, antiplatelet agents, fibrinolytics and ethanol leads to an increase in side symptoms glucocorticosteroids and estrogen is increased. As a result, ulcers appear, internal bleeding and impaired renal function.

The cost of Ketoprofen

The drug is in demand, which is due not only to efficiency, but also to availability. The cost of the drug in the form of injections ranges from 220 to 250 rubles. The drug in tablet form will cost 200 rubles, which contains 20 tablets in a package. The cost of the drug in the form of candles is from 200 to 300 rubles for 12 pieces.

Summing up, it should be noted that in the event of the occurrence or presence of indications, one should not rush to the pharmacy, because first you need to make sure of the diagnosis and the need for treatment with this drug. The medicine can be used strictly after the appointment of the attending physician.

Magnesium sulfate intramuscularly instruction for beginners and pros Ortofen: what are the injections for? non-steroid drug

One of popular means intended for local anesthesia, relieving inflammation in the ligaments, muscles, tendons, is Ketoprofen. The gel must be rubbed into problem areas.

Composition and form of release

Means are able to quickly provide analgesic and anti-inflammatory effects. This group of drugs includes "Ketoprofen"-gel. Its composition, in addition to the main active ingredient, ketoprofen, also includes water, lavender oil, ethanol, carbomer, trolamine.

The gel is packaged in aluminum tubes of 30, 40 and 50 g each. He looks like transparent ointment(it may be colorless or with a slight yellowish tinge). Each gram of the drug contains 25 or 50 mg of ketoprofen, depending on which gel you buy: 2.5 or 5 percent.

Indications

In the instructions you can find information that the tool is used for the following problems:

Inflammatory diseases of any part of the musculoskeletal system;

Pain in the muscles of both rheumatic and non-rheumatic origin;

Inflammation that has developed as a result of trauma, for example, with injuries or ruptures of ligaments, various bruises.

So, a remedy is prescribed for articular syndrome, which accompanies an exacerbation of gout, for psoriatic and rheumatoid arthritis, radiculitis, osteoarthritis with radicular syndrome, spondylitis, bursitis, lumbago, sciatica and inflammatory lesions tendons and ligaments.

Operating principle

Before you start using a drug called Ketoprofen, it is important to understand that it is not able to eliminate the cause of the problem. Its action is aimed at alleviating the patient's condition. It can well anesthetize, relieve inflammation, but it cannot stop the progression of the disease. This information is contained in the instructions for use attached to the preparation "Ketoprofen" (gel). Reviews, description of the remedy by people who are far from medicine can be misleading. Indeed, many say that with the help of this remedy they managed to temporarily get rid of a particular disease. But in fact, the drug helps to eliminate the symptoms of the disease. The remedy reduces the feeling of morning stiffness in the joints, eliminates swelling, and reduces arthralgia in articular syndrome.

The active substance of the drug "Ketoprofen" can relieve inflammation and anesthetize due to the fact that it inhibits the activity of COX-1 and COX-2 (cyclooxygenase), which regulate the production of prostaglandins.

How to use

If you are concerned about pain in the muscles, ligaments or joints, then you can buy "Ketoprofen" (gel). The instruction contains everything necessary information about how to use it. So, it can only be used externally. To do this, a small amount of the product (a thin strip 3-5 cm long) is squeezed onto the problem area and rubbed in a circular motion. You can do this up to 3 times a day.

If it is necessary to treat children, then please note that a smaller amount of the drug is sufficient for them. On the skin of small patients, no more than 1-2 cm of gel should be applied up to 2 times a day. It can be used from the age of 6.

It is important to know that you can use the drug on your own for no more than two weeks in a row. If during this period the condition has not improved, then it is necessary to consult a specialist.

Often, doctors prescribe Ketoprofen (gel) for phonophoresis. The instruction for this drug allows the use of the drug for the treatment of problem areas with the mentioned physiotherapeutic method.

Contraindications

If you decide to self-medicate or the drug was prescribed to you by a doctor who is not familiar with your medical history, then before using the remedy, you need to find out in which cases this is prohibited.

So, if your skin is damaged at the intended site of application, then you can not use this drug. So says the instruction attached to each tube of Ketoprofen-gel. The price for it, of course, may attract you, but for eczema, wounds, weeping dermatosis, infected abrasions, the drug cannot be used.

Also, contraindications include a complete or even partial combination of recurrent pollinosis (a complex of allergic reactions), the presence of bronchial asthma and intolerance to non-steroidal anti-inflammatory drugs, including acetylsalicylic acid.

Do not prescribe Ketoprofen gel to children who are under 6 years old, women during the third trimester of pregnancy and lactation.

Important nuances

Before you start using the drug, you need to familiarize yourself with the information contained in the instructions attached to the Ketoprofen (gel) product. Reviews can be conflicting, and this document clearly spells out those cases when the drug should be used with caution. So if you have pronounced violations liver or kidney function, ulcerative or erosive lesion Gastrointestinal tract, hepatic porphyria or chronic heart failure, bronchial asthma, it is better to consult a doctor before using the remedy. It is also necessary to be careful during pregnancy and in old age. Do not self-administer the drug to children aged 6 to 12 years.

Regardless of whether the doctor prescribed Ketoprofen gel to you, or whether you decide to purchase it yourself, you need to know that when used externally active substance absorbed into the body slowly. At the same time, its bioavailability does not exceed 5%. So, when rubbing into the skin of a drug containing up to 150 mg of ketoprofen, in the blood plasma after 5-8 hours its amount will not exceed 0.15 μg / ml.

Features of use

Having bought the drug "Ketoprofen" (gel), you need to figure out exactly how it can be used. So, you can apply it only on undamaged areas of the skin. It is important to ensure that it does not fall on open wounds, ulcerative surfaces, as well as on the mucous membranes and in the eyes.

After rubbing the product into the skin, wash your hands thoroughly with soap. In addition, you can not use "Ketoprofen" in the places of application. This type of dressing includes those that are applied to seal the wound. For example, they are necessary for wounds in the area chest so that the victim can breathe.

This drug does not affect the patient's ability to administer complex mechanisms or vehicles.

Side effects

In addition to the list of contraindications, it is advisable to familiarize yourself with what Ketoprofen (gel) can cause. It is better to look for analogues of the drug in cases where it is contraindicated for you or you are afraid of the manifestation of any problems. So, experts point out the possibility of developing a number of adverse reactions. They are divided into local or systemic.

The former include skin flushing, eczema, exanthema, photodermatitis, bullous or allergic dermatitis, purpura. Among the systemic reactions are the following: edema, stomatitis, photosensitivity, generalized rash, urticaria.

If you notice any of side effects, then it is advisable to stop using the drug immediately and consult a doctor.

The cost of the drug, storage features and method of dispensing from pharmacies

Many people wonder why this drug is popular, and what is the price of Ketoprofen gel. Patient reviews indicate that at an affordable cost in terms of efficiency, it is not inferior to more advertised products, for example, such as Fastum Gel. It is worth noting that "Ketoprofen" is a generic of the specified foreign medicine. Your doctor may prescribe any of these drugs, but before changing one to another, it is better to consult a specialist.

Before finding out how much Ketoprofen (gel) costs, you need to clarify what dosage of the active substance you need. For example, a 30-gram package containing 2.5% ketoprofen can cost about 55 rubles, and 5% - 100 rubles. Also, the price will depend on the capacity of the tube: the more funds in the package, the more expensive it is.

Ketoprofen gel is sold in pharmacies without a prescription, so you can buy it without visiting a doctor. The product is stored for 2 years in a dry, dark place. The temperature should not exceed 15-25 degrees. Freezing of the drug is not allowed.

Analogues

If patients are interested in what the drug can be noticed, then the doctor in the hospital or the pharmacist in the pharmacy can offer several options. So, instead of Ketoprofen, Fastum Gel can be prescribed. It contains the same active ingredient, but it costs much more. So, a 30-gram package with a 2.5% concentration of ketoprofen will cost you approximately 205 rubles.

A cheaper analogue is Bystrumgel, although it is also more expensive than Ketoprofen. A tube containing 30 g of 2.5% of the product costs about 188 rubles. It contains the same active substance, therefore, according to the principle of action, the drugs do not differ much. And although manufacturers claim that Bystrumgel is more effective, it is difficult to prove this.

The Flexen gel is somewhat more affordable than the indicated analogues: a tube with 30 g of the drug can be purchased for 130 rubles.

Another analogue is the gel "Artrosilen". It contains the lysine salt of Ketoprofen 5%. A package with 50 grams of this gel will cost about 350 rubles.

In all these means, a list of indications for use, contraindications and possible side effects approximately the same. After all, they all contain one active ingredient - ketoprofen.

Ketoprofen is considered an NSAID. It produces an analgesic effect, as well as antipyretic, it copes well with many inflammations. Of all these effects, anti-inflammatory is the least pronounced. Ketoprofen blocks the production of prostaglandins, thereby relieving pain.

Release form, composition and packaging

The remedy has several forms:

Gel- applied externally, it happens 2.5% and 5%.
Tableted- 100 and 150 mg.
Composition for intravenous injections and injections.
Rectal suppositories.

The main ingredient of the drug is Ketoprofen. Additional ingredients available including essential oil lavender (mainly in gel form).

The cost of the drug

The price of the drug is as follows:

The price of the medicine for intravenous injections and intramuscular injections. 10 ampoules - from 225 rubles to 243 rubles.
The cost of Ketoprofen in a dragee (has an enteric coating). 100 mg, 20 pieces - from 186 rubles to 247 rubles.
Ketoprofen 15% in aerosol. Price - from 129 rubles to 311 rubles.
Ketoprofen in the form of suppositories. 100 mg 12 pieces - from 201 rubles to 301 rubles.

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Ketoprofen injections

Pharmacology and description

The injections are available in ampoules of 50 mg / ml. They have the same effects as the tablet form, only their anti-inflammatory effect is more pronounced. About read here.

Pharmacokinetics:

Suction medicinal substance lasts 25-30 minutes.
Does not have a storage function.
Almost entirely absorbed in the liver.
It is removed from the body 8 hours after ingestion.
Displayed using MPS.

Indications for use

Inflammatory and deforming diseases of the musculoskeletal system: rheumatoid and psoriatic arthritis, inflammation of the spine and joints, arthritis, osteoarthritis.
pain various etiologies. The medicine reduces pain, but cannot stop the pathology.

Contraindications

Contraindications are as follows:

Individual intolerance to the components of the drug.
Bronchitis.
Allergy to NSAIDs.
Pollinosis of the nose.
Peptic ulcer of the stomach and duodenum.
Gastritis with high acidity.
Problems with the blood coagulation system.
Bleeding of various etiologies.
Pyelo and glomerulonephritis, as well as acute renal failure.
Rehabilitation period after heart surgery.
Hyperkalemia.
Gastroduodenitis.
Age up to 17 years.
Pregnancy.
Breast-feeding.
During pregnancy

The medicine we describe forbidden to drink during pregnancy. This was confirmed by the experiments of scientists, they proved that taking Ketoprofen during pregnancy, especially its 3rd trimester, can have an adverse effect on the heart of the embryo.

If you use this drug, you may experience delayed psychomotor development of the child as well as pathology respiratory system baby.

Therapy with Ketoprofen is possible only on early dates and only if the potential benefit to the mother outweighs the risk of malformations of the baby. In addition, this drug increases the tone of the uterus, which threatens miscarriage.

At the planning stage of conception, you should also not use Ketoprofen, because it prevents the implantation of the egg. At breastfeeding also not to be used.

Mode of application

Use Ketoprofen intravenously and intramuscularly. IV infusions are carried out through a dropper, in a hospital setting. V / m injections can be done at home, in accordance with the doctor's prescriptions, but, as a rule, 1-2 times a day.

IV injections are carried out as follows:

It is necessary to dissolve 1-2 ampoules of the drug in 100-200 ml of 0.9% sodium chloride solution. The resulting solution is administered through a dropper for 30-60 minutes. Re-introduction of the drug can be carried out no earlier than 8 hours from the end of the previous dropper. This method is considered a short infusion.
Continuous infusion- this is when also 2 ampoules are added to 500 ml (0.9% infusion solution, Ringer's solution, 5% dextrose solution). The specified solution is administered within 8 hours. Subsequent administration is also possible after 8 hours.

Given that the infusion solution is very sensitive to light, the bottle must be wrapped with a dark cloth or paper. Maximum possible dose Ketoprofen per day - 200 mg.

The drug we describe can be mixed well with many medicines to achieve the best therapeutic effect. These drugs may include: analgesics general action and morphine. But all this is done only with the consent of the doctor.

The duration of the drug no more than 3 days. If treatment needs to be continued for a longer time, then similar drugs are prescribed.

Side effect

There are many side effects, but fortunately they are rare.

They are the following:

From the side of digestion: often irritation of the gastric mucosa, pain in the abdominal region, dyspeptic disorders, less often - stomatitis, liver problems, rarely - ulcers on the gastrointestinal mucosa; extremely rarely - bleeding of various etiologies, taste disturbance.
From the NA side: often - migraine, dizziness, weakness, bad dream, nervousness. Drowsiness, mood disturbances also take place. Less often - hallucinations and loss of consciousness, memory problems, headaches, peripheral neuropathy.
From the sense organs: rarely - extraneous sounds in the ears, blurred vision, conjunctivitis, dryness of the mucous membrane of the eye, pain in the eye sockets, heat in the eyes, decreased hearing, loss of balance.
From the CCC: rarely - hypertension; very rarely - palpitations.
From the side of the CC: rarely - agranulocytoma, anemia, thrombocytopenia, leukopenia.
From the MPS: sometimes - edema. Rarely inflammation. Bladder, inflammation of the urethra, impaired functioning of the kidneys, inflammation of the kidneys, extremely rarely - blood in the urine.
Allergy Phenomenon: often - skin rash, pruritus. Rarely - runny nose, bronchospasm, exfoliative dermatitis; rarely - angioedema, anaphylactic shock.
Other: infrequently - sweating, blood in the sputum. Rarely - epistaxis, myalgia, muscle twitching, shortness of breath, dryness of the mucous membranes of the oral cavity, inadequate reactions to the effect of ultraviolet radiation.

If the drug is used for a long time, may appear vaginal bleeding. If you notice any of these side effects, see your doctor immediately.

Overdose

In case of an overdose, the following reactions are possible:

Dyspeptic disorders;
confusion;
breathing problems;
Violation of the kidneys;
Renal failure.

In case of an overdose, you should immediately call a doctor, as it will not be possible to help on your own.

Requires hospitalization: symptomatic treatment, monitoring the work of the respiratory system and the cardiovascular system, it is mandatory to take blockers of H2-histamine receptors, Pg inhibitors. There is no remedy that will quickly relieve the effect of an overdose. Apparatus " artificial kidney» is not effective.

Interaction

Under no circumstances should this drug be used together with Tramadol.
Ketoprofen renders kidney drugs ineffective, but the effect of anticoagulants, antiplatelet agents, fibrinolytics, ethanol, side effects of glucocorticosteroids and minerals of corticosteroids, estrogens are enhanced.

That is why the combination with other NSAIDs, glucocorticosteroids, ethanol, corticotropin leads to ulcers and bleeding, as well as impaired kidney function.

Do not use Ketoprofen together with oral anticoagulants, thrombolytics, antiplatelet agents, cefoperazone, cefamandol and cefotetan, as otherwise bleeding of any etiology may occur.
Ketoprofen enhances the effect of blood sugar lowering agents.
It also makes oral hypoglycemic agents more effective. medicines mi.
Combination with angiotensin-converting enzyme inhibitors(ACE), angiotensin II antagonists, cyclosporine, tacrolimus leads to the risk of high content potassium in the blood and kidney disease.
Increases the content of substances that make up cardiac glycosides in the blood.
Probecid prevents Ketoprofen from being absorbed into in full Therefore, the use of these agents together is undesirable.
Ketoprofen reduces the effectiveness of mifepristone.
Reception of Ketoprofen is allowed only after 13 days after the end of taking the specified drug.

Whatever it was, but if you are already using some medicines, then be sure to consult your doctor are they compatible with Ketoprofen.

special instructions

Pay attention to them:

The price of Amitriptyline tablets (25 mg, 50 pcs.): 40-80 rubles.

pharmachologic effect

Anti-inflammatory drug - a derivative of arylcarboxylic acid.

Ketoprofen is an antipyretic, anti-inflammatory, analgesic that inhibits platelet adhesion (aggregation). The work of the drug is to inhibit the enzyme, which is actively involved in the synthesis of prostaglandins in the body and reduce the biosynthesis of biologically active substances produced by the body (prostaglandins). The role of prostaglandins is very multifunctional in the human body, they are responsible for the manifestation of pain and swelling in the area of inflammation.

Ketoprofen relieves joint pain during rest and movement. It also helps to reduce swelling and stiffness of the joints, increasing the range of motion in the morning.

Indications for use

Long-term treatment of inflammation of the joints, aimed at getting rid of the symptoms, without touching the very cause of the disease, treatment of an infectious-allergic disease from the group of collagenoses, which has a chronic character developing inflammation joints ( rheumatoid arthritis), treatment of diseases of the spine (ankylosing spondyloarthritis), treatment chronic inflammation joints in patients with psoriasis (psoriatic arthritis), treatment of certain joint diseases (arthritis) accompanied by pain.

Short-term symptomatic relief from pain: inflammation of the joint (arthritis), extra-articular rheumatism, back pain, arthrosis, acute radiculitis. In tablet form, the drug is used in large doses in long-term maintenance treatment. The drug in the form of a gel is used for not very complex injuries, rupture or sprain of ligaments and tendons, muscles, post-traumatic edema and pain, bruises of ligaments and muscles.

Mode of application

The beginning of treatment consists in the use of the drug at a dosage of 300 mg per day 2-3 times with meals.

As a maintenance treatment, the drug is prescribed at a dose of 150-200 mg per day with meals (1 capsule 3 times a day, or 1 retard tablet).

In candle therapy daily dose is 2 suppositories of 100 mg. Morning evening.

The drug in the form of a gel is applied twice a day, which must be rubbed for a long time into painful areas and places where there is inflammation. You can apply a dry bandage after application. It is necessary to avoid getting the gel on the surface of the mucous membranes.

Side effects

Gagging, vomiting, abdominal pain, diarrhea, may cause stomach ulcers or duodenum; bleeding, possibly hidden, intestinal perforation. Drowsiness, headaches, dizziness. Skin rashes(allergy), bronchospasm (narrowing of the lumen of the bronchi). If a rash develops on the skin after using the gel, it is urgent to stop treatment with its use.

Contraindications

severe violations of the kidneys;
severe violations of the liver;
peptic ulcer of the duodenum and stomach in the acute phase;
third trimester of pregnancy;
the period of breastfeeding;
age up to 14 years;
eczema, weeping dermatoses and infected wounds (for cream);
proctitis, proctorrhagia (for suppositories);
particular sensitivity to salicylates and ketoprofen.

Ketoprofen during pregnancy and lactation

No studies have been conducted to judge the safety of this medicinal product during pregnancy.

Treatment with Ketonal in the first and third trimesters of pregnancy is acceptable, but only if the benefit to the pregnant woman outweighs the risk to the baby. The use of the drug Ketonal in the third trimester of pregnancy (especially after 36 weeks) is unacceptable, as this may affect the tone of the uterus.

If the mother has an urgent need to use Ketorofen, it is worth giving up breastfeeding as soon as possible.

special instructions

This drug should be used with caution in gastrointestinal bleeding, peptic ulcer stomach and duodenum, liver and kidney failure.

It is worth knowing and considering in the future, the fact that the drug has the ability to mask the symptoms of diseases caused by infections. Patients who use lithium preparations and anticoagulants in conjunction with Ketonal should be monitored by a medical specialist.

Overdose

There have been no cases of overdose due to the use of Ketonal.

Ketoprofen belongs to the group of non-steroidal and is a derivative of propinoic acid.

The anti-inflammatory effect of Ketoprofen is on par with Indomethacin and Naproxen and surpasses the anti-inflammatory effect of Ibuprofen and Aspirin. The analgesic effect of Ketoprofen is similar to that of Indomethacin and Naproxen.

Pharmacological effects

Ketoprofen contributes to the provision of analgesic, antipyretic and anti-inflammatory effects.
Anti-inflammatory action can be achieved after 7 days of oral administration of the drug.

In the event that the drug is used to treat articular syndrome, then Ketoprofen will help eliminate pain syndrome both at rest and during movement, it will eliminate symptoms such as morning stiffness and joint swelling. Against the background of the use of the drug, an increase in mobility is observed.

Gel Ketoprofen contributes to the provision of local anesthetic action. When used locally, the concentration active component persists for a long period of time at the site of inflammation.

Release form, composition

The drug Ketoprofen is available in the form of forte tablets, retard tablets, capsules, gel, suppositories, injection, cream.

The capsules contain 50 mg of the active ingredient.
Forte tablets contain 100 mg of the active ingredient.
Retard tablets contain 150 mg active substance. This form of the drug has a prolonged action, which allows you to take pills only once a day.
The composition of the gel (1 gram) contains 25 mg of the active substance.
The composition of the solution for injection contains 50 mg of the component (in 1 ml of the drug).
The composition of the cream (1 gram) contains 50 mg of the active substance.
The suppositories contain 100 mg of the active substance.

The selection of one form or another of the drug Ketoprofen is carried out by the doctor, depending on the indications for the use of the drug and concomitant symptoms.

Indications for use

Indications for the use of the drug Ketoprofen for systemic use(by mouth, intravenously, rectally, intramuscularly) are the following conditions:

Complex therapy of inflammatory and degenerative diseases(rheumatoid arthritis, non-specific spondylitis, gouty arthritis, pseudogout, osteoarthritis, bursitis, tendovaginitis).
Elimination of intense pain sensations of various origins, including postoperative and post-traumatic pain, sciatica, myalgia, treatment of sciatica, bruises and muscle strains, renal colic.
The drug is used in dentistry and gynecology (including primary dysmenorrhea).
Intravenous Ketoprofen is used to eliminate pain in diseases of the musculoskeletal system.

Ketoprofen for external use is used:

AT complex treatment sharp and chronic diseases musculoskeletal system, including rheumatoid arthritis, arthrosis, osteochondrosis.
With painful traumatic or inflammatory lesions of the joints, ligaments, tendons: arthritis, muscle bruises, bursitis, sprain and rupture of ligaments, dislocations.
In the treatment of phlebitis, thrombophlebitis, inflammatory diseases skin.

Contraindications

Contraindications to systemic use are such conditions: the presence of peptic ulcer of the stomach or duodenum, "aspirin" asthma, ulcerative colitis in the acute stage, Crohn's disease, peptic ulcer, bleeding disorders. The drug is not used for renal and liver failure, as well as in childhood up to 18 years and in the third trimester of pregnancy.

Ketoprofen gel and cream are not used for weeping dermatoses, eczema, infected abrasions, violations of the integrity of the skin, in children under 6 years of age.

Adverse reactions

Ketoprofen may contribute to the development of such side effects.
Central nervous system: possible development of headache, nervousness, dizziness, insomnia, strange dreams, drowsiness, malaise, tinnitus, visual disturbances, general malaise.

Cardiovascular system: increase blood pressure, increased heart rate, development of peripheral vascular disease, anemia, thrombocytopenia.

Gastrointestinal tract: some patients may complain of nausea, constipation, flatulence, pain in the abdomen. In rare cases, the formation of stomatitis, vomiting, increased appetite, dry mouth, rectal bleeding, increased salivation, occult bleeding.

Respiratory system: development of nosebleeds, bronchospasm, pharyngitis, rhinitis, laryngeal edema.

Skin: the development of allergic reactions in the form of a rash, itching and burning, redness of the skin, alopecia, oncholysis, bullous rash, toxic epidermal necrolysis.

Other adverse reactions associated with the occurrence of chills, swelling of the face, weight gain.

In the event that Ketoprofen causes the described or any other side effects, the use of the drug should be discontinued. It may be necessary to reduce the dosage or change the medication, at the discretion of the attending physician.

Overdose

In case of an overdose of the drug, dizziness, lethargy, vomiting, nausea, and abdominal pain may develop. Side effects are reversible. As a treatment, it is necessary to wash the stomach, carry out symptomatic and supportive therapy. In addition, it is necessary to monitor the state of the respiratory and cardiovascular systems.

Mode of application

Ketoprofen is intended for internal, intramuscular, intravenous, rectal, cutaneous and topical use. The dosage and method of application are selected individually, taking into account the severity of the disease and associated symptoms.

As required, it is allowed to combine several dosage forms drug. Only a doctor should prescribe the drug and select the dosage!
Infusions using the drug should be carried out only in stationary conditions.

Ketoprofen in the form of tablets, capsules and granules must be taken during or after the main meal. This avoids the development of side effects from the gastrointestinal tract.

The use of the drug Ketoprofen is possible with extreme caution and only under medical supervision if the patient has an allergy to aspirin drugs, peptic ulcer, diabetes, anemia, alcoholism, renal and chronic heart failure, high blood pressure.

If the patient's history includes allergic reactions, the use of non-steroidal anti-inflammatory drugs, including Ketoprofen, is possible only in extreme cases.

The use of Ketoprofen may help to mask the symptoms of various infectious diseases.

For external use, do not allow the medicine to get into the eyes, on damaged areas of the skin and on the mucous membranes.

When using the drug by patients whose activities require heightened attention and concentration, it should be remembered that Ketoprofen may affect the reaction rate.

Cost, analogues

The cost of Ketoprofen for the period January-February 2015 is formed as follows:

Gel Ketoprofen external, 30 grams (Russia) - 45-50 rubles.
External gel, 50 grams (Russia) - 60-70 rubles.

Analogues of Ketoprofen are the following medicines: Ketonal, Bystrumgel, Artrum, Artrozilen, Flamax, Flexen.