Nise gel: instructions for use and what it is needed for, price, reviews, analogues. Medication "Nise" - gel for external use

Nise is a non-steroidal drug used for inflammation. This medicine reduces swelling, severity pain and helps normalize body temperature. Widely used to eliminate manifestations inflammatory reactions for diseases of the musculoskeletal system and injuries.

Nise comes in tablet and gel form. Its active component is the substance nimesulide.

The tablets have a flat-cylindrical biconvex shape. They are smooth to the touch, the color is almost white with a subtle yellowish tint. One tablet contains 100 mg active component.

They contain the following excipients:

calcium hydrogen phosphate;
cellulose with microcrystalline structure;
starch obtained from corn grains;
talc;
magnesium stearate;
sodium carboxymethyl starch;
colloidal silicon dioxide.

Each blister contains 10 tablets. A cardboard pack may contain 1, 2 or 10 blisters. Nise Kid dissolvable tablets are also produced, designed primarily for children. Quantity active substance they contain 50 mg.

Gel is a thick translucent substance yellow color, free from visible impurities. The concentration of nimesulide is 1%. Additional components of the gel are:

macrogol;
N-methyl-2-pyrrolidone;
propylene glycol;
isopropanol;
carbomer;
thiomersal;
butylated hydroxyanisole;
potassium dihydrogen phosphate;
aromatic component "narcissus-938";
water.

The gel is produced in laminated tubes made of aluminum. Their capacity can be 20 or 50 g. The tube with the gel is placed in a cardboard pack.

There is another form of the drug - granules intended for the preparation medicinal suspension. This form of medication is optimal for treating children.

What is it used for?

The use of the drug is indicated for:

arthritis (including rheumatoid and psoriatic);
radiculitis;
lumbago;
sciatica;
osteochondrosis;
presence of radicular syndrome;
bursitis;
osteoarthritis;
arthralgia;
ankylosing spondylitis;
inflammatory diseases ligaments and tendons;
myalgia (both rheumatic and non-rheumatic in nature);
inflammatory processes in soft tissues caused by bruises, sprains, ligament ruptures and other injuries;
pain resulting from injuries and after surgery;
headache, dental, periodic female pain;
febrile conditions, including against the background of infectious and inflammatory diseases.

The use of this product is effective when acute phases inflammation, accompanied by pain, swelling and fever.

pharmachologic effect

Nise is a non-steroidal anti-inflammatory drug belonging to the sulfonanilide class. At its core, nimesulide, on which the action of the drug is based, is a selective inhibitor of COX-2 (an enzyme necessary for the synthesis of prostaglandins responsible for the development of pain, swelling and inflammatory reactions).

Reversible suppression of prostaglandin E2 synthesis is observed not only in the area of inflammation, but also in the pathways of pain impulses located in the tissues spinal cord. Thanks to these properties, the drug promotes:

removing or reducing the severity of inflammation;
pain relief;
reducing elevated body temperature.

In addition, the active substance contained in the drug slows down the reactions of synthesis of endoperoxides and thromboxane A2 and prevents the activation of plasminogen. This prevents the release of histamine and may reduce the severity of bronchial spasm.

The medicine slows down the effect negative factors leading to necrotic tissue changes.

Nise significantly slows down the synthesis reactions of interleukin-6, urokinase and metalloprotease, which helps prevent the destruction of cartilage tissue.

Studies have confirmed that the drug has an antioxidant effect and also promotes the activation of glucocorticoid receptors. This further enhances its therapeutic effect.

After entering the digestive tract, the tablets are well absorbed into the blood. Eating food reduces the rate of absorption, but its extent does not change. The maximum concentration of nimesulide in the blood is observed 1.5-2.5 hours after taking the medicine. The degree of binding to blood plasma proteins reaches 95%.

At the site of inflammation, the concentration of the drug is about 40% of that found in the plasma. Approximately the same high content is observed in synovial fluid and in the female genital organs. The drug passes through the histo-hematological barriers almost unhindered.

In the liver, the drug undergoes intensive metabolism. The main metabolite is 4-hydroxynimesulide (about 25%), which has similar pharmacological properties.

The half-life of nimesulide varies between 1.5-5 hours, and 4-hydroxynimesulide - 2.9-4.8 hours. Approximately 65% of metabolites are excreted through the kidneys and 35% along with bile.

The effect of the gel is local, it is limited to the area of its application.

Instructions for use

Pills

The tablets are best taken before meals, and for patients with gastrointestinal diseases intestinal tract It is recommended to consume them immediately after meals. An adult should drink 100 mg of the drug (1 tablet) 2 times a day. If necessary, the daily dose can be increased to 400 mg. Course of treatment without special purpose doctor should not exceed 10 days.

Gel

The gel is applied evenly thin layer onto the area of skin in the affected area (you should squeeze out a strip approximately 3 cm long, but this amount may differ from that given depending on the area of pain). It should be applied without physical effort, without rubbing. It can be used a maximum of 3-4 times a day.

Before applying the gel, the area of skin in the area of pain must be washed and wiped dry. You should not use the gel for more than 10 days in a row without appropriate medical advice.

Ointment

Nise is not available in ointment form. Often an ointment is mistakenly called a gel.

Contraindications and side effects

Nise should not be used for:

erosions, ulcerative lesions and inflammatory diseases digestive tract in the acute phase;
tendency to gastrointestinal bleeding;
increased likelihood of developing other internal hemorrhages;
liver diseases accompanied by serious disturbances in its functioning;
severe forms of renal failure or progressive kidney disease;
a history of bronchospasm caused by taking acetylsalicylic acid or another non-steroidal anti-inflammatory drug;
severe heart failure in the stage of decompensation;
hyperkalemia;
diseases that cause bleeding disorders (including hemophilia);
alcohol or drug addiction;
hypersensitivity to nimesulide or to the auxiliary components of this medicine;
pregnancy;
breastfeeding.

If the patient has undergone surgery coronary artery bypass surgery, use the drug in recovery period forbidden.

If there are serious chronic diseases This product can only be used as prescribed by a doctor, observing necessary measures precautions.

The drug may cause the following side effects:

problems with functioning digestive system(abdominal pain, heartburn, nausea, vomiting, diarrhea);
formation of erosions and ulcers of the gastrointestinal tract;
increased concentration of liver enzymes in the blood;
toxic hepatitis;
reactions from the central nervous system ( headache, dizziness, drowsiness);
kidney failure;
retention of excess fluid in the body;
increased duration of bleeding;
deterioration of blood analysis indicators;
allergic reactions(skin rashes, urticaria, anaphylactic shock, bronchospasm);
skin itching, peeling and change in skin color (when using the gel).

If side effects occur, you should stop taking the medicine and tell your doctor. It should be borne in mind that the gel long-term use over large areas can lead to the same systemic side effects, as when using forms of the drug intended for oral use.

Application for children

Tablets of 100 mg can be prescribed from 12 years of age, and gel from 7 years of age. The recommendations here are the same as for adult patients. Children aged 2 to 12 years can take Nise Kid tablets or suspensions with the same name orally, while children under 3 years old can only be given the suspension.

Nise Kid 50 mg dispersible tablets are taken after eating; the tablet should first be dissolved in a teaspoon of water. It is better to drink the suspension before meals.

For children under 12 years of age, a single dose is set at the rate of 3-5 mg of the active ingredient per 1 kg of weight. The medicine is taken 2-3 times a day. Your doctor will help you determine the optimal dose and duration of treatment.

special instructions

If the drug is used long time, it is necessary to regularly monitor the functioning of the liver and kidneys. After using the gel, you should wash your hands thoroughly with soap.

Avoid contact of the gel with damaged or affected areas of the skin. skin diseases, as well as on mucous membranes and eyes. Airtight dressings should not be used when using the gel.

If it is necessary to use the medicine during lactation, breastfeeding should be suspended.

Question about controllability vehicle or other potentially dangerous mechanism is decided taking into account the patient’s tolerability of the drug.

Drug interactions

It should be noted that the use of Nise simultaneously with:

Warfarin, acetylsalicylic acid, non-steroidal and steroidal anti-inflammatory drugs increases the likelihood of bleeding (most often gastrointestinal);
with other non-steroidal anti-inflammatory drugs leads to an increase in the concentration of lithium in the blood plasma with possible manifestation toxic effects;
with Furosemide reduces the effectiveness of the latter;
with Methotrexate increases its concentration and enhances its toxic properties;
with cyclosporines increases the likelihood toxic damage kidney

In this situation, you may have to stop taking one of the medications or change its dosage.

Analogs

Similar medicinal properties have:

Diclofenac;
Ketonal;
Actasulide;
Dexalgin;
Nurofen;
Voltaren;
Dolgit.

It is recommended to first consult with a specialist about the possibility of replacing Nise with analogues.

Drug price

A package of regular tablets of 100 mg (20 pieces) and Nise Kid tablets of 50 mg (20 pieces) can be bought for 205 rubles, a tube with 20 g of gel - for 195 rubles, a pack of granules for preparing suspension No. 9 (100 mg , 2 g) - for 260 rubles.

Nise ointment is a medicine that has a strong anti-inflammatory effect. This drug contains an active component that belongs to a number of non-steroidal anti-inflammatory drugs. Therefore, Nise ointment has a mild and gentle therapeutic effect and is not hormonal drug. Also, the ointment contains a complex of additional substances, which has a auxiliary effect, eliminates pain and discomfort.

Indications

Nise ointment is a popular anti-inflammatory drug used to treat various diseases musculoskeletal system and soft tissues. This tool prevents the development of the inflammatory process, and also significantly shortens the period of regeneration of damaged tissues. The use of Nise ointment provides an immediate feeling of freshness and comfort, increases motor activity and well-being.

Nise ointment is indicated in the following cases:

Painful sensations in the muscles and organs of the musculoskeletal system;
Arthritis and arthrosis;
Rheumatoid diseases, radiculitis and gout;
Inflammation of the periarticular bursa;
Myalgia and neuralgia;
Tendenitis;
Osteoarthrosis and osteochondrosis.

The drug can be used both for the treatment of certain diseases characterized by inflammation and pain, and for the purpose of restoring soft tissues and joints after injuries, bruises, and sprains.

The ointment can provide first aid for injury or bruise, eliminate pain, swelling and stiffness in movement. In addition, it is effective in exacerbation chronic forms diseases.

The use of Nise ointment is contraindicated in the following cases:

Individual intolerance to substances present in the composition;
Allergic reaction and bronchospasm when using drugs containing acetylsalicylic acid;
Gastrointestinal ulcers;
Violation of the integrity of the skin, irritation or inflammation of the skin in the area of the planned application of the product.

Important! In rare cases, while using the ointment, it is possible to develop side effect, which is expressed by a local allergic reaction.

Compound

Nise ointment is an effective anti-inflammatory agent containing a complex of active and safe substances. The drug perfectly combats various unpleasant sensations, inflammation and heaviness in movements, allows you to speed up the healing process and make you feel better.

Nise ointment contains a complex of active substances that have a pronounced therapeutic effect:

Nimesulide is the main active component of this ointment, which belongs to a number of non-steroidal anti-inflammatory drugs. This component has a pronounced anti-inflammatory and analgesic effect. It also has some antipyretic effect. Nimesulide can be found in many medicines aimed at treating various diseases of the musculoskeletal system.
Menthol is an effective analgesic and local irritant component that copes with various unpleasant sensations that arise from illness or injury. When applied to the skin as an ointment, menthol gives a feeling of coldness and freshness, which suppresses the feeling of pain and burning. In addition, menthol is an excellent tonic soft fabrics and increases protective properties body.
Methyl salicylate is a substance that has an analgesic effect. It fights pain and also has anti-inflammatory effects. Methyl salicylate also perfectly removes swelling and congestion from fabrics.
Capsaicin is a component with a strong local irritant effect. It blocks nerve impulses responsible for pain and discomfort, makes you feel better and gives you a feeling of freshness. In addition, capsaicin stimulates blood microcirculation in the problem area, which improves the metabolism of substances in cells and accelerates the regeneration of damaged tissues.

The price of Nise ointment is 200 rubles. The drug is produced in tubes of 20 and 50 grams.

Conclusion

Nise ointment is an effective anti-inflammatory agent that has an analgesic and local irritant effect. The drug is used for injuries or diseases of the musculoskeletal system, and also has an excellent preventive effect. The complex of active substances present in the ointment formulation eliminates pain and improves metabolic processes in tissues and accelerates their recovery.

In 2017 Nise gel entered the top twenty most purchased medicines in Russia. The drug has analgesic and anti-inflammatory properties. Among the indications is a long list of disorders in the musculoskeletal system. Modern technologies made it possible to reduce the list of side effects, which is why the ointment is approved for use in children over 7 years of age.

Composition and mechanism of action

A transparent product of a pale yellow color, which has a rather dense consistency, belongs to the second generation of medications containing nimesulide, an antipyretic anesthetic, as an active ingredient. It regulates fat metabolism, inhibits the production of active lipid compounds, reduces the aggregation of blood platelets, the release of histamine and blocks the process of destruction of collagen, a protein found in cartilage. Being an antioxidant, it reduces the level of harmful metabolites that cause tissue poisoning and activates hormonal receptors, enhancing the anti-inflammatory effect.

Excipients in Nise gel are:

Methyl salicylate. Provides distracting and local irritating effects.
Menthol. Stimulates cold receptors, stabilizes calcium transport through the membranes of nerve cells.
Capsaicin. Provides local increased blood circulation, hyperemia, stimulates the release of biologically active substances of endogenous nature.

The composition belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs), which are not hormones and do not have multiple side effects. Designed to block cyclooxygenases (COX) - enzymes responsible for the synthesis of prostaglandins. One type of enzyme (COX-2) creates compounds that regulate inflammation, and the other (COX-1) promotes the synthesis of substances that protect the gastrointestinal mucosa from digestive secretions. But NSAIDs do not differentiate them due to their similar chemical structure. As a result, the risk of bleeding in the digestive canal increases.

Nimesulide has a gentle mechanism of influence: stronger on inflammatory enzymes and weaker on defense enzymes. Diclofenac and other acidic NSAIDs affect COX-1 and COX-2 with equal potency.

What does Nise ointment help with?

European organizations that test the effectiveness of drugs recommend taking tablet forms of nimesulide only in short courses. In the USA they were not allowed on the pharmaceutical market. In some European countries they have been withdrawn from circulation. As for the gel, the risk of side effects is minimal, since the drug has a local rather than systemic effect.

Indications for use of Nise ointment:

But that’s not all that Nise ointment successfully helps with. It is effective if you are worried about: bronchospasms, stiffness in the joints in the morning. The composition has antioxidant properties, therefore it slows down the release of toxins, relieves pain, processes associated with inflammation and swelling of tissues.

Instructions for use

The product contains toxic alcohols and is therefore intended for external use only. In case of contact with mucous membranes, it may cause burns. The composition is applied in a thin layer to clean, dry, undamaged skin. Possible burning is a normal reaction. After some time, the unpleasant sensations disappear on their own. The number of treatments for lesions is up to 3-4 times a day. Duration of treatment is from 1 to 2 weeks.

After the procedure, you must wash your hands with soap. Avoid contact with mucous membranes. Do not treat skin covered with a breathable dressing.

The instructions for use of Nise ointment note that the active components of its composition are poorly absorbed into the bloodstream and do not have a systemic effect. At the same time, the level of nimesulide is 300 times less than when taken orally.

Side effects and overdose

Nise ointment helps with symptomatic treatment, but does not eliminate the cause of the disease. For diagnoses of congestive heart failure, hypersensitivity, gastro-duodenal bleeding, it can only be used under the supervision of a specialist.

The drug is contraindicated in the following pathological conditions:

tendency to allergies;
ulceration and erosion at the acute stage due to the possibility of bleeding;
liver and kidney diseases;
open wounds on the skin, irritation;
type II diabetes.

The gel should not be used by children under 7 years of age, pregnant women and women breastfeeding. Physician supervision will be required when treating elderly patients.

Nise ointment is absolutely safe when used minimally effective dosages and shortest duration of treatment. Extremely rarely: dizziness, nausea, skin rashes, itching. With hypersensitivity, leukopenia, anemia, and development of anaphylactic reactions: bronchospasms, shortness of breath, vasomotor rhinitis, Quincke's edema. During treatment, you should not visit a solarium and, if possible, avoid UV irradiation.

Cases of overdose are practically not described. With frequent use, systemic reactions of the body become more pronounced. No official antidote has been found for the drug. Therefore, if you suspect poisoning, you should call an ambulance.

Caution will be required when taking antidiabetic and antihypertensive compounds, as well as methotrexate, diuretics, cyclosporins and other immunosuppressive drugs, phenytoin, digoxin, simultaneously with nimeluside.

Nise ointment reviews

Evgeniy, 32 years old

“Nise is always with me in my sports bag, it saves me from pain after a workout.”

Anastasia, 40 years old

“Nise cream has helped more than once with sprains, fatigue in the knees and lower back. I keep it in the first aid kit at the dacha and take it with me on camping trips. It’s somehow calmer with him.”

Muzafarov, doctor of the traumatology department

“You can find very different reviews about Nise ointment. This is the main remedy in my prescriptions. There are many indications: osteoarthritis, inflammation of ligaments, joint capsules, dorsopathic pain. But I don’t recommend self-medicating.”

Price and analogues

Nise is a cheap drug for its segment and is available without a doctor’s prescription, but before using it, consultation with a specialist is still required. Price of Nise ointment weighing 50 g. starts from 300 rubles.

In pharmacies you can find many options that have similar therapeutic effects:

An analogue in composition or even a substitute is Nimesulide.
Anti-inflammatory properties are characteristic of Diclofenac gel, but it copes with pain worse and has more wide range contraindications.
Nimulid gel (India). A non-narcotic drug to relieve pain. Not recommended during pregnancy and lactation.
Diklovit (Russia). A drug with antiaggregation, antipyretic, analgesic properties. Apply 2-3 times a day.
Voltaren Emulgel (Switzerland). Relieves swelling, eliminates pain. Contraindicated in the last trimester of pregnancy. Not recommended during breastfeeding.
Diklak (Switzerland). Contains diclofenac sodium as an active ingredient classified as an NSAID. Has a pronounced analgesic effect.

AND Russian drug Indomethacin. Increases range of motion, relieves pain, reduces swelling. Helps with traumatic inflammation of the joints, myalgia, problems in the spine, rheumatoid arthritis and other pathologies of the musculoskeletal system. Has multiple side effects. Reception requires supervision by specialists. Available without a prescription.

Doctor's report

Among non-steroidal anti-inflammatory drugs, Nise attracts patients with a number of advantages, including:

safety;
absence of allergens;
impact on the epicenter of pain.

The drug is used as a component symptomatic treatment. It successfully copes with swelling and morning stiffness, which is why it has become one of the most purchased medicines, but it has a serious drawback - it does not eliminate the cause of the condition. Therefore, for more serious therapy, it is necessary to consult a doctor, undergo an appropriate examination, and accurate diagnosis and developing a treatment regimen that takes into account multiple factors.

With joint pathologies, many people experience severe pain which may cause serious problems. If you don't take action necessary treatment, then over time they intensify and simply do not allow you to live normally.

For this reason, many doctors recommend using medications to reduce inflammation and pain. One of these is Nise gel. Using this tool You can quickly eliminate pain, improve the structure of joints and completely eliminate the inflammatory process.

But still, before using it, you need to study the features of the Nise gel, instructions for use, prices and cheaper analogues.

Components, release form

The medication Nise is produced in the form of a 1% gel, which intended for local use. The gel is placed in tubes made of aluminum material.

Tubes are produced in two volumes - 50 and 20 grams. The tubes are contained in cardboard boxes. The gel has a transparent, light yellow, yellow structure.

The main element in Nise ointment is nimesulide. It is this element that reduces the synthesis of prostaglandins.

They provoke the appearance of unpleasant painful sensations, as well as symptoms of edema. Besides, nimesulide reduces platelet formation, thereby preventing the development of necrosis of the affected tissue.

Nimesulide is one of the main components; it is the basis of the drug. The content of this component in 1 gram of gel is 10 mg. All other components complement it and enhance each other's actions.

In addition to nimesulide, there are other active elements, for example, a derivative component of acetylsalicylic acid, namely methyl salicylate.

Due to this component, when the product is applied to the affected area, active irritation occurs. This causes increased blood circulation in it, but at the same time all pathogenic processes slow down and completely die out.

Included There is menthol, which has a calming effect. As a result of its action, activation of cold receptors is observed, and calcium ions begin to freely penetrate through the channel areas of the neuron membranes, which saturate and strengthen the structure of the tissues of the joints and bones.

In addition to the main elements, the composition contains additional components:

Properties

Before you start applying Nise gel, you should definitely study it beneficial features. The abstract highlights the following positive effects of this medicine:

when used, the active components quickly penetrate the affected area and have a direct effect on the focus of the pathological process;
suppresses the spread of the inflammatory process;
removes quickly increased fever, redness;
increases blood circulation and accelerates healing;
has antiplatelet and analgesic effects;
suppresses the formation of prostaglandins in areas with an inflammatory process;
selectively inhibits cyclooxygenase type 2.

Rarely appear when using medications side symptoms.

This is due to the fact that Nise inhibits the synthesis of prostaglandin in the area of healthy tissue. It has a slowing effect on the peroxidative reactions of lipids and their metabolites, while not affecting the state of hemostasis and phagocytosis.

The medication in gel form has a local analgesic and anti-inflammatory effect. With its regular use, there is a reduction or complete elimination of pain in the joints at rest or when performing movements.

It also eliminates joint stiffness and swelling, which can appear in the morning.

Price

The price of Nise gel in pharmacies has some differences, it all depends on the manufacturer and the volume of the tube. On average, tubes with a volume of 20 grams can be purchased for 120-150 rubles. A 50 gram tube sells from 180 to 300 rubles.

Comparison of Nise gel analogues

Nise gel has quite a lot of analogues that have the same effects and properties. But these funds may have some differences - cost, period and degree of action, composition. In order to choose a suitable analogue, it is worth carefully studying the properties of each.

By price

Sometimes not everyone can afford it original drug, because it has a fairly high cost. To cheaper analogues of Nise gel Russian production The following drugs include:

Nimesulide

The cost of this product ranges from 80 to 400 rubles. Nimesulide gel has the same effect as Nise.

This remedy reduces discomfort, inflammation, and eliminates swelling. When used it occurs fast recovery joints, stiffness disappears in the morning.

Nemulex

The price of this product is from 210 rubles. The medicine is produced in the form of granules, which are used to prepare a suspension.

The suspension is taken orally. Provides rapid decline pain and discomfort.

Nimulid

The price of the drug can be from 110 to 430 rubles. Produced in different forms– in the form of gel, ointment, suspension, tablets.

With this medicine treat pathologies of a rheumatic nature.

And also when used it is provided quick fix pain.

Analogs from other manufacturers

Naisulide

The cost of the medicine can be from 35 to 150 rubles. Produced in the form of tablets, gel, powder.

This remedy reduces unpleasant feelings, prevents the development of inflammation and heat. This analogue of Nise gel ointment with nimesulide is the most inexpensive.

Nimesubel

The cost of the medicine can be from 35 to 195 rubles. The medicine is produced in the form of tablets, gel or suspension. Used to reduce discomfort in osteoarthritis, dysmenorrhea.

Nimik

The average price of this medication starts from 120 and reaches 250 rubles. Used to reduce pain, inflammation in osteoarthritis, pathologies of rheumatic origin, and in the postoperative period.

Diclofenac gel

On average, this product costs from 50 to 80 rubles. Used to eliminate inflammation and pain in rheumatic diseases. Eliminates symptoms of swelling.

By composition

To analogues of Nise with the same active substance The following drugs include:

Sulaydin

This drug contains nimesulide, its dosage in 1 gram of gel is 10 mg. In addition to this component, there are additional components - diethylene glycol monoethyl ether, glycerol monooleate, hydroxypropylcellulose. The drug reduces pain, inflammation, fever.

Mesulid

The main element of the drug is nimesulide. The gel also contains additional components - carbomer, ethyl alcohol, macrogol 400, dimexide, propylene glycol. When used, discomfort in the joints is eliminated, inflammation and heat are relieved.

Nimesulide

The gel contains the main element – nimesulide. In 1 gram its dose is 10 mg. There are also additional elements - carbomer, macrogol 400, ethyl alcohol, propylene glycol, dimexide. When used, joint pain, inflammation are reduced, and swelling is eliminated.

Other effective analogues

The following can be found on sale in many pharmacies: effective analogues Nise gel.

Ibuprofen

The gel contains 50 mg of ibuprofen. When used, it prevents the development of inflammation, also quickly eliminates pain, and relieves fever. Recommended for use in rheumatoid diseases.

Voltaren Emulgel

This drug contains diclofenac, its dose in 1 gram is 10 mg. Helps eliminate severe inflammation, pain, intense fever. Prevents morning joint stiffness and swelling.

Ketonal gel

Medicine containing ketoprofen. Has anti-inflammatory, antipyretic, analgesic effects.

Any analogue of Nise gel has its own contraindications, side symptoms, and features of use. For this reason, before you start using any medicine, you must carefully study the instructions for use.

Nonsteroidal anti-inflammatory drugs are used in most areas of modern medical practice, but most often they are prescribed to patients suffering from rheumatological diseases and nonspecific inflammatory processes musculoskeletal system. A prominent representative of NSAIDs is the drug Nise, created on the basis of nimesulide, which is highly effective and provides a rapid onset of analgesic effect.

This medicine is reliable way solutions to many problems with joints, interarticular cartilage tissues, tendons. It is often recommended for patients with sprains muscle tissue, inflammation of bone joints, diseases of the spine of a degenerative-destructive nature, and the like. Nise can be used as pain relief after surgical interventions or dental treatment. This medicine has proven itself to be a faithful assistant in the fight against inflammation of non-infectious origin. A huge advantage of the drug is the possibility of its use in childhood.

Instructions for using the medicine

This representative of the NSAID group has several types of action, including analgesia, anti-inflammatory and decongestant. In addition, the drug has a pronounced antipyretic effect, which allows it to be used to relieve fever of various origins.

What does Nise help with? The drug is used for the symptomatic treatment of a huge number of pathological conditions, in particular, it is prescribed for diseases of the spine, pain syndrome associated with injuries, menstrual pain, headaches and toothaches. The medicine helps to quickly reduce elevated temperature, accompanying viral and bacterial infections, it reduces the ability of platelets to aggregate and prevents the formation of blood clots.

Nise is one of the medications whose use causes numerous side effects. Long-term and regular use of the medicine can cause various allergic reactions of local and general, violations from the central nervous system and disorders of the functioning of the digestive tract in the form of gastritis, diarrhea, flatulence, and the like. Often the urinary organs react to taking the medication, which is manifested by the occurrence of local swelling, hematuria, painful urination And renal failure. Often, after using the medicine, patients complain of shortness of breath, disorders heart rate, hemorrhages throughout the body, exacerbation of symptoms bronchial asthma. Rarely, after using the drug, people experience worsening vision, a decrease in temperature, and general weakness.

The drug has great amount contraindications that should be taken into account before starting to take it:

individual intolerance to the components of the product;
previous allergic reactions to structural analogues of the drug;
period of pregnancy and breastfeeding;
diseases of the stomach and intestinal tract in the acute phase;
a person has bronchial asthma and frequent attacks bronchospasm of various etiologies;
hemophilia and bleeding disorders;
failure internal organs at the stage of decompensation;
alcohol dependence and drug addiction;
rehabilitation period after coronary artery bypass surgery;
gastrointestinal bleeding.

A drug overdose occurs as a result of non-compliance with the recommended doses of the drug. Its symptoms are manifested by the development of dyspepsia, nausea and vomiting, increased blood pressure, sometimes severe impairment of kidney function and convulsive syndrome. Treatment of overdose comes down to washing the patient’s stomach and taking sorbents, as well as prescribing laxatives and symptomatic therapy.

Nise: tablets for internal use

Tablets are the main form of the drug for internal reception. They are taken orally during or after main meals. This helps prevent irritation of the mucous membranes of the stomach. Regular tablets are prescribed to children over 12 years of age and adults. Taking medication in preschool and younger children school age prohibited.

Dispersed tablets are also available. This form of release of the drug is intended for patients over 3 years of age. Before use, pills must be dissolved in clean water and then drink without drinking big amount liquids. Like regular tablets, the dispersed version of the medication should be used only for full stomach. Water for dissolution is taken in the ratio of 1 tablet per 5 ml of liquid.

The recommended dose of the drug for adults and older children, as well as people over 65 years of age, is 100 mg (2 tablets) twice a day. If necessary, it can be increased to 4000 mg per day, but this is the maximum daily dosage facilities. If the specified amounts are not observed, the patient may experience poisoning.

Young children take the drug in quantities calculated according to the following scheme: 3-5 mg of active substance per kilogram of the child’s body weight. The duration of taking the drug is determined by the attending physician.

Nise gel

Dosage form is used for local application as a means to relieve local pain. Before applying the medication, the skin at the site of exposure should be treated with soapy water and wiped with a towel. If a wound appears on the skin in the area where pain is projected and symptoms of inflammation appear or there are signs of irritation (dermatitis), then applying the gel is prohibited.

The gel is applied to the skin 3-4 times a day. To do this, you need to squeeze out about 3 cm of the product from the tube and rub it into the skin with soft massage movements. After the procedure, the treatment site can be covered with gauze or left open. Anesthetic medicine should not be covered on top with materials that do not allow air to pass through.

The use of the gel must be strictly according to the instructions. Before use, it is better to visit a doctor and decide on individual doses, duration of treatment, etc. It is not recommended to use the product for more than four days, since after this period the risk of side effects increases sharply. In some cases, the gel is prescribed in courses lasting 10 days.

After applying the product to the skin, a superficial burn may occur locally, the manifestations of which go away on their own after a few days. In addition, the components of the gel can provoke itching and burning. skin, which indicates that the patient has an individual intolerance to some components of the drug. After using the product, a person should wash their hands well to prevent the gel from getting into the eyes or mucous membranes. Maximum daily dose the product should not exceed 30 g, that is, 1.5 tubes.

Ointment Nise

The non-steroidal anti-inflammatory drug is available in tubes for topical use. This is a so-called gel that should be applied to the skin in areas of pain. Many people who do not know the subtleties of distributing medications into forms mistakenly confuse it with an ointment. It is important to understand that Nise is produced exclusively in the form of a gel and has no analogues identical in name among liniments.

Nise - composition of the drug

The composition of the drug depends on the form of its release. Regular tablets contain:

nimesulide as the main active ingredient in the amount of 100 mg per tablet;
excipients, including talc, starch, cellulose, calcium hydrogen phosphate and others.

The tablets are white flat cylinders with a smooth surface.

The drug in the form of dispersible tablets contains:

nimesulide – 0.050 g per tablet;
talc, starch, cellulose, pineapple flavor, aspartame, silicon dioxide.

Gel for topical use contains nimesulide 1% (10 ml of gel - 1 g of nimesulide). The medicine is packaged in 20 ml tubes. This is a gel white without visible inclusions and pungent odors.

Indications for use of the drug

Among the main indications for the use of the drug are:

rheumatoid arthritis of large joints and polyarthritis;
exacerbation of gouty arthritis;
arthritis of psoriatic origin with severe pain;
ankylosing spondylitis;
radicular syndrome with radiculitis, neuralgia, radiculopathy;
osteochondrosis of the spinal column;
myalgia of various origins;
inflammatory processes of the constituent parts of the joints, including aseptic inflammation during sprains, damage to the capsule and muscle structures;
pain syndrome, regardless of origin;
hyperthermia.

The drug can be used internally, as well as locally by applying to the skin. The medicine is indicated for adults and children over 12 years of age. Soluble tablets can be used in young patients who have reached the age of three.

Nise: price of the drug

Patients often ask how much it costs this drug, because it is one of the foreign medicines? Indeed, the product costs a little more domestic analogues, but still its price remains acceptable for the majority of our fellow citizens.

Today you can purchase the drug at any pharmacy. The dosage form is available without a prescription, but before use it is recommended to mandatory consult with specialists regarding dosages, frequency of administration and duration of the therapeutic course.

Analogs that can replace the drug

Mostly, patients are interested in analogues of the drug when they are looking for a cheaper replacement. In the case of Nise substitutes, the pharmaceutical market is simply replete with an abundance of drugs from the NSAID group, among which a person can purchase:

generics of the drug or its structural analogues (drugs identical in composition and main active ingredient);
analogues according to the principle of action (medicines where the main active ingredient is not nimesulide, but another NSAID).

Among the most popular drugs containing nimesulide are the drug Nimesulide itself, Aulin Ameolin, Nimesil Nimulide and others. If a person is intolerant to nimesulide, he may be offered an NSAID based on another active component, in particular, Artron, Mesulide, paracetamol preparations, Diclofenac, Dicloberl, Structum, and the like.