Rules for using nise gel. What helps and how to use Nise ointment

The medicine "Nise" (ointment) is used

To relieve inflammation musculoskeletal system,

For articular syndrome accompanying rheumatism,

During an exacerbation of gout,

With osteochondrosis with radicular syndrome,

For ankylosing spondylitis.

This drug also helps with radiculitis, osteoarthritis, inflammation of ligaments and tendons, bursitis and inflammation of soft tissues after injuries.

During muscle pain of various origins, it is also often recommended to use the medicine “Nise” (ointment). Instructions for use involve local application of the drug. At the same time, it causes a decrease in the intensity of pain or its disappearance, and significantly reduces morning swelling and stiffness of the joints. As a result, the amplitude and number of available movements increases.

"Nise" is an anti-inflammatory drug that does not contain steroids. In addition to its main purpose, this remedy also has antipyretic, decongestant, cooling and analgesic effects. Due to the influence on enzymes that are involved in the synthesis of prostaglandins, which, in turn, are intermediaries in the formation of edema, inflammation and, as a result, pain, the drug “Nise” (ointment) is capable of this phenomenon.

In addition, the drug inhibits the formation of toxic oxygen breakdown products, that is, it has antioxidant properties. When applied topically, the effect becomes noticeable after about a month of use.

The total duration of treatment is determined by specialists depending on the size of the painful area, as well as the patient’s individual response to the drug.

With prolonged use, it is necessary to systematically monitor renal function. Areas of skin treated with ointment do not need to be covered with occlusive dressings.

Ointment "Nise": instructions regarding contraindications and possible adverse reactions

Adverse reactions when using Nise ointment can be different. When applied topically, peeling, itching, urticaria, and changes in skin color are possible. However, the latter is not a reason to discontinue the drug. If the ointment is applied, there is a possibility of adverse reactions such as diarrhea, heartburn, gastralgia, nausea or vomiting, ulceration of the gastrointestinal mucosa, headaches and dizziness, hematuria, fluid retention, anemia, as well as such allergic reactions like skin rashes or anaphylactic shock.

Also when using this drug possible increase in the duration of bleeding, thrombocytopenia, leukopenia, agranulocytosis. If adverse reactions occur, you should immediately stop using Nise (ointment) and consult a specialist.

This drug should be used with caution in elderly patients due to the frequency of cases at this age. cardiovascular diseases, arterial hypertension, gastrointestinal disorders, renal dysfunction or bleeding tendency, especially during treatment with antiplatelet agents and anticoagulants. Diabetics should also take the drug in strictly dosed doses, since it contains sucrose.

It is strictly contraindicated to use “Nise” (ointment) during pregnancy and lactation. However, if the drug needs to be used, then breast-feeding It's better to stop. It should also not be used for dermatoses and skin lesions. It is necessary to ensure that “Nise” (ointment) does not get on the mucous membranes and especially in the eyes. Also cannot be used this remedy for the treatment of children under two years of age.

The use of the drug is contraindicated in case of hypersensitivity to nimesulide, other components of the drug, as well as to other anti-inflammatory drugs that do not contain steroids, and acetylsalicylic acid.

Nonsteroidal anti-inflammatory drugs are used in most areas of modern medical practice, but most often they are prescribed to patients suffering from rheumatological diseases and nonspecific inflammatory processes musculoskeletal system. A prominent representative of NSAIDs is the drug Nise, created on the basis of nimesulide, which is highly effective and provides a rapid onset of analgesic effect.

This medicine is reliable way solutions to many problems with joints, interarticular cartilage tissues, tendons. It is often recommended for patients with sprains muscle tissue, inflammation of bone joints, diseases of the spine of a degenerative-destructive nature, and the like. Nise can be used as pain relief after surgical interventions or dental treatment. This medicine has proven itself to be a faithful assistant in the fight against inflammation of non-infectious origin. A huge advantage of the drug is the possibility of its use in childhood.

Instructions for using the medicine

This representative of the NSAID group has several types of action, including analgesia, anti-inflammatory and decongestant. In addition, the drug has a pronounced antipyretic effect, which allows it to be used to relieve fever of various origins.

What does Nise help with? The drug is used for symptomatic treatment huge amount pathological conditions In particular, it is prescribed for diseases of the spine, pain associated with injuries, menstrual pain, headaches and toothaches. The medicine helps to quickly reduce elevated temperature, accompanying viral and bacterial infections, it reduces the ability of platelets to aggregate and prevents the formation of blood clots.

Nise is one of the drugs whose use causes the development of numerous side effects. Long-term and regular use of the medicine can cause various allergic reactions of local and general, violations from the central nervous system and functioning disorders digestive tract in the form of gastritis, diarrhea, flatulence and the like. Often the urinary organs react to taking the medication, which is manifested by the occurrence of local swelling, hematuria, painful urination And renal failure. Often, after using the medicine, patients complain of shortness of breath, disorders heart rate, hemorrhages throughout the body, exacerbation of symptoms bronchial asthma. Rarely, after using the drug, people experience worsening vision, a decrease in temperature, and general weakness.

The drug has great amount contraindications that should be taken into account before starting to take it:

individual intolerance to the components of the product;
previous allergic reactions to structural analogues of the drug;
period of pregnancy and breastfeeding;
stomach diseases and intestinal tract in the acute phase;
a person has bronchial asthma and frequent attacks bronchospasm of various etiologies;
hemophilia and bleeding disorders;
failure internal organs at the stage of decompensation;
alcohol dependence and drug addiction;
rehabilitation period after coronary artery bypass surgery;
gastrointestinal bleeding.

Overdose medicine occurs as a result of non-compliance with the recommended doses of the drug. Its symptoms are manifested by the development of dyspepsia, nausea and vomiting, increased blood pressure, sometimes severe impairment of kidney function and convulsive syndrome. Treatment of overdose comes down to washing the patient’s stomach and taking sorbents, as well as prescribing laxatives and symptomatic therapy.

Nise: tablets for internal use

Tablets are the main form of the drug for internal reception. They are taken orally during or after main meals. This helps prevent irritation of the mucous membranes of the stomach. Regular tablets are prescribed to children over 12 years of age and adults. Taking medication in preschool and younger children school age prohibited.

Dispersed tablets are also available. This form of release of the drug is intended for patients over 3 years of age. Before use, pills must be dissolved in clean water and then drink without drinking big amount liquids. Like regular tablets, the dispersed version of the medication should be used only for full stomach. Water for dissolution is taken in the ratio of 1 tablet per 5 ml of liquid.

The recommended dose of the drug for adults and older children, as well as people over 65 years of age, is 100 mg (2 tablets) twice a day. If necessary, it can be increased to 4000 mg per day, but this is the maximum daily dosage facilities. If the specified amounts are not observed, the patient may experience poisoning.

Small children take the drug in quantities calculated according to the following scheme: 3-5 mg active substance for every kilogram of the child’s body weight. The duration of taking the drug is determined by the attending physician.

Nise gel

Dosage form is used for local application as a means to relieve local pain. Before applying the medication, the skin at the site of exposure should be treated with soapy water and wiped with a towel. If a wound appears on the skin in the area where pain is projected and symptoms of inflammation appear or there are signs of irritation (dermatitis), then applying the gel is prohibited.

The gel is applied to the skin 3-4 times a day. To do this, you need to squeeze out about 3 cm of the product from the tube and rub it into the skin with soft massage movements. After the procedure, the treatment site can be covered with gauze or left open. Anesthetic medicine should not be covered on top with materials that do not allow air to pass through.

The use of the gel must be strictly according to the instructions. Before use, it is better to visit a doctor and decide on individual doses, duration of treatment, etc. It is not recommended to use the product for more than four days, since after this period the risk of side effects increases sharply. In some cases, the gel is prescribed in courses lasting 10 days.

After applying the product to the skin, a superficial burn may occur locally, the manifestations of which go away on their own after a few days. In addition, the components of the gel can provoke itching and burning. skin, which indicates that the patient has an individual intolerance to some components of the drug. After using the product, a person should wash their hands well to prevent the gel from getting into the eyes or mucous membranes. Maximum daily dose the product should not exceed 30 g, that is, 1.5 tubes.

Ointment Nise

The non-steroidal anti-inflammatory drug is available in tubes for topical use. This is a so-called gel that should be applied to the skin in areas of pain. Many people who do not know the subtleties of distributing medications into forms mistakenly confuse it with an ointment. It is important to understand that Nise is produced exclusively in the form of a gel and has no analogues identical in name among liniments.

Nise - composition of the drug

The composition of the drug depends on the form of its release. Regular tablets contain:

nimesulide as the main active ingredient in the amount of 100 mg per tablet;
Excipients, including talc, starch, cellulose, calcium hydrogen phosphate and others.

The tablets are white flat cylinders with a smooth surface.

The drug in the form of dispersible tablets contains:

nimesulide – 0.050 g per tablet;
talc, starch, cellulose, pineapple flavor, aspartame, silicon dioxide.

Gel for topical use contains nimesulide 1% (10 ml of gel - 1 g of nimesulide). The medicine is packaged in 20 ml tubes. This is a gel white without visible inclusions and pungent odors.

Indications for use of the drug

Among the main indications for the use of the drug are:

rheumatoid arthritis of large joints and polyarthritis;
exacerbation of gouty arthritis;
arthritis of psoriatic origin with severe pain;
ankylosing spondylitis;
radicular syndrome with radiculitis, neuralgia, radiculopathy;
osteochondrosis of the spinal column;
myalgia of various origins;
inflammatory processes of the constituent parts of the joints, including aseptic inflammation during sprains, damage to the capsule and muscle structures;
pain syndrome, regardless of origin;
hyperthermia.

The drug can be used internally, as well as locally by applying to the skin. The medicine is indicated for adults and children over 12 years of age. Soluble tablets can be used in young patients who have reached the age of three.

Nise: price of the drug

Patients often ask how much this drug costs, since it is one of the foreign medicines? Indeed, the product costs a little more domestic analogues, but still its price remains acceptable for the majority of our fellow citizens.

Today you can purchase the drug at any pharmacy. The dosage form is available without a prescription, but before use it is recommended to mandatory consult with specialists regarding dosages, frequency of administration and duration of the therapeutic course.

Analogs that can replace the drug

Mostly, patients are interested in analogues of the drug when they are looking for a cheaper replacement. In the case of Nise substitutes, the pharmaceutical market is simply replete with an abundance of drugs from the NSAID group, among which a person can purchase:

generics of the drug or its structural analogues (drugs identical in composition and main active ingredient);
analogues according to the principle of action (medicines where the main active ingredient is not nimesulide, but another NSAID).

Among the most popular drugs containing nimesulide are the drug Nimesulide itself, Aulin Ameolin, Nimesil Nimulide and others. If a person is intolerant to nimesulide, he may be offered an NSAID based on another active component in particular, Artron, Mesulide, paracetamol preparations, Diclofenac, Dikloberl, Structum and the like.

Nise is an anti-inflammatory drug that can have antipyretic, antiplatelet and analgesic effects. Prescribed when inflammatory diseases. The drug belongs to the pharmacological group of NSAIDs, the main active ingredient is nimesulide.

Nise is intended for both oral and external use. Available in the form of tablets, lozenges, dispersible tablets, soluble tablets, suspension, granules (for suspension), granules (for solution), gel.

One tablet contains the main active ingredient - nimesulide - in an amount of 100 milligrams (and the dispersible tablet contains 50 milligrams) and excipients such as calcium phosphate, magnesium stearate, corn starch, talc, pineapple flavor, colloidal silicon dioxide, microcrystalline cellulose, calcium carboxymethyl starch .

Five milliliters of suspension contain the main active ingredient - nimesulide - in an amount of 50 milligrams and excipients such as purified water, sorbitol, pineapple flavor, glycerol, methylparaben, sucrose, polysorbate 80, propylparaben, lemon acid, gum, yellow quinoline dye W.S. . The suspension has a characteristic taste and pleasant odor, yellow color.

One percent gel, contains the following excipients: water, thimserosal, propylene glycol, flavoring, isopropanol, potassium phosphate, butylated hydroxyanisole, N -methyl-2-pyrrolidone, carbomer-940, PEG-400.

Indications for use Nise

Nise is recommended for use when the following diseases: tendonitis, bursitis, pain syndrome, radiculitis, Bheterov's disease, febrile syndrome, myalgia, algodismenorrhea, neuralgia, inflammation of soft and bone tissues due to injury, arthritis, osteochondrosis (mainly with radicular syndrome), articular syndrome (for example, with gout), lumbago, sciatica, osteoarthritis, inflammation of ligaments and tendons.

Contraindications to the use of Nise

Nise is contraindicated in patients suffering from hypersensitivity to the components of this drug, peptic ulcers stomach or intestines, liver and kidney failure, gastric or intestinal bleeding, aspirin asthma, heart failure, arterial hypertension, diabetes mellitus second type. It is prohibited to take Nise in the third trimester of pregnancy, during lactation, for patients under 12 years of age (for tablets), for patients under 2 years of age (for suspensions). The gel is contraindicated if it is present on the area of application. open damage, dermatosis and other skin lesions.

Nise Use during pregnancy and children

Contraindicated during pregnancy and breastfeeding.

Drug interactions

Care should be taken when simultaneous use nimesulide with the following drugs (due to the drugs competing for binding to plasma proteins): digoxin, phenytoin and lithium drugs, diuretics and antihypertensive drugs, other NSAIDs, cyclosporine, methotrexate and antidiabetic agents, anticoagulants (dispersible tablets). Pills. The effect of medications that reduce blood clotting is enhanced when used simultaneously with nimesulide. Nimesulide may reduce the effect of furosemide; increase the development of side effects when simultaneous administration methotrexate. Plasma lithium levels increase when lithium and nimesulide are taken simultaneously. Use with GCS and SSRIs increases the risk of gastrointestinal bleeding.

Nise dosage

Nise is taken internally or externally. Tablets, suspension, granules for suspension and solution are intended for oral use. The gel is intended for external use.

It is recommended to take the tablets before meals, however, if after taking the tablets were recorded discomfort in the stomach, it is permissible to take the drug after meals. Patients over 12 years of age are prescribed from 200 to 400 milligrams per day (2-4 tablets), one tablet per dose.

Dispersible tablets are pre-dissolved in water (a teaspoon of water is required per tablet). For patients aged 3 to 12 years, the required dose of the drug is calculated based on body weight. Patients over 12 years of age are prescribed 100 milligrams (2 tablets) per dose, twice a day.

The suspension can be taken by patients over 2 years of age; for them, the dose of the drug is calculated based on body weight, as well as for all adolescents whose body weight does not exceed 40 kilograms. For patients whose body weight exceeds 40 kilograms, the daily dose is 200-400 milligrams of the active substance (20-40 milliliters of suspension).

The gel is applied directly to the painful area, the skin of which has been thoroughly washed and dried. The gel is applied to the most sore spot a column three centimeters long, after which it is carefully distributed over the sore area thin layer(without rubbing). The procedure is carried out 3-4 times a day.

Maximum course of use drug Nise is 10 days, it is not recommended to exceed the time of taking Nise.

Nise gel is a drug for topical use that belongs to the anti-inflammatory group non-steroidal drugs. The medication is successfully used in the treatment of diseases of an inflammatory nature, bursitis, tendovaginitis, osteoarthritis, and osteoarthritis. The medicine can be purchased in the form of a gel, ointment or cream. It has anti-inflammatory, antipyretic and analgesic effects.

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Release form and composition

The drug is produced in tubes of 20 g and 50 g. It is in cardboard packages. The medicine is free from foreign particles and has a yellow, transparent or light yellow color.

1 g of the medicine contains 10 mg of the active ingredient nimesulide.

The composition of Nise gel, cream and ointment includes the following excipients:

thimerosal;
propylene glycol;
flavorings;
pyrrolidone;
isopropanol;
potassium phosphate;
macrogol;
940 carbomer.

Pharmacology

This anti-inflammatory drug is of non-steroidal origin and belongs to the sulfonanilide type. Nimesulide is the active element of the drug, which has antipyretic, analgesic and anti-inflammatory effects. This action is due to the selective shutdown of 2-cyclooxygenase.

Methanol has antipruritic, antiseptic, analgesic, sedative and local thinning effects. The effect of the drug is associated with reflexes that appear due to irritating effects on the mucous membranes and nerve endings of the receptors. The medicine releases and produces elements that take an active part in vascular permeability and regulation of pain. They provide antipruritic and distracting effects.

External and local use of the product is accompanied by a feeling of coldness and vasoconstriction. It turns into a tingling and burning effect. These processes improve vascular tone and tissue trophism.

Methyl salicylate is hydrolyzed, actively penetrates, is absorbed and converted into an anion salicylic acid. The substance reduces the production of prostaglandins and lowers cyclooxygenase. These elements are responsible for increased body temperature, soreness, inflammation and swelling. Methyl salicylate reduces painful sensations in tissues, muscles and joints, normalizes capillary permeability.

Indications

Indications for use of Nise gel, ointment or cream - relief of inflammation and pain. Medical drug used in the following cases:

radiculitis;
tendon inflammation, sciatic nerve, ligaments;
chondrosis;
osteoarthritis;
rheumatism and gout;
ankylosing spondylitis;
joint disease due to psoriasis and rheumatoid nature;
pain in ligaments and muscles due to injury.

Mode of application

Nise gel, cream and ointment are prescribed externally only. It is necessary to follow the dosage prescribed by the attending physician and indicated in the instructions for use. Before starting the procedure, you need to prepare the affected area. It must be dry and clean. It is necessary to squeeze out the product no more than 2 cm long. The medicine is applied to the sore spot with gentle movements and a thin layer.

The medication is allowed to be used no more than four times a day. The duration of therapy is 14 days. If after 10 days there is no positive effect from therapy, you should consult your doctor.

The drug is not recommended for use if there is damage to the skin. A few minutes after applying the ointment, gel or cream, a burning sensation may be observed. Do not allow the medicine to come into contact with mucous membranes or eyes.

For joint diseases, it must be used during a period of complete or unstable remission.

Side effects and overdose

When using Nise ointment, cream or gel, adverse reactions may occur. Quite rarely, hives, burning sensations, changes in skin color, itching, swelling or peeling occur. With such symptoms, the drug is not canceled, as they go away on their own after a few days.

If you use medical product over time, the following reactions may occur:

anemia;
fluid retention;
burning behind the sternum and in the larynx;
nausea and vomiting;
digestive disorders;
the occurrence of erosions and small ulcers on the mucous membrane;
thrombocytopenia;
headache, migraine and feeling of dizziness;
change in blood test;
the occurrence of allergies, in rare cases anaphylactic shock;
development of liver transaminase activity.

In such cases, it is necessary to discontinue the drug and consult your doctor for advice and change the treatment regimen.

No cases of drug overdose with Nise have been identified. Negative side effects may appear due to an exceeded dosage of 50. There is no official antidote, so if side effects develop, it is necessary to call " ambulance" and begin symptomatic treatment.

Contraindications

Contraindications include the following conditions:

hypersensitivity to one of the components of the gel;
acute damage to the digestive system by ulcers or erosions;
stomach/intestinal bleeding;
dermatoses of various etiologies, damage to the upper layers of the epidermis;
infectious diseases skin;
acute renal failure;
pathological processes in the hematopoietic system;
history of bronchospasms caused by the use of other anti-inflammatory drugs.

The drug should not be used by pregnant women. If they have joints painful sensations, you should consult your doctor for advice. He will appoint similar means. Breastfeeding must be stopped during treatment.

active ingredients: 1 g of gel contains nimesulide 10 mg, methyl salicylate 100 mg, menthol 50 mg, capsaicin 0.25 mg

Excipients: diethyl phthalate, diethylene glycol monoethyl ether, polyethoxylyvane hydrogenated castor oil, propylene glycol, sodium benzoate (E 211), Trilon B, butylated hydroxytoluene (E 321), carbomer, trometamol, purified water.

Dosage form

White or almost white gel without visible foreign inclusions.

Manufacturer name and location

Dr. Reddy's Laboratories Ltd.

M/s Group Pharmaceuticals Ltd, No. 41, Nasigere Village, Kasaba COPD, KIADB, Malur - 563130, Kolar get., India.

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Pharmacological group

Drugs used locally for joint and muscle pain. ATS code M02A A.

Nise gel contains nimesulide, a selective inhibitor of cyclooxygenase-2. It has an analgesic and anti-inflammatory effect due to inhibition of the release of cyclooxygenase-2, which leads to inhibition of the synthesis of prostaglandins involved in the formation of edema and pain during inflammation. Nimesulide inhibits platelet activating factor, tumor necrosis factor alpha, the release of proteinases and histamine.

Methyl salicylate, a derivative of salicylic acid, has a local irritating and distracting effect.

Menthol has an analgesic effect, which is accompanied by a feeling of cold. The analgesic effect of menthol is associated with stimulation of cold receptors, stabilization of the flow of calcium ions through the channels of neuronal membranes.

Capsaicin has a local irritant effect, causes a local increase in blood flow and tissue hyperemia at the site of application, and promotes the release of endogenous biologically active substances.

When Nise gel is applied externally, it is gradually absorbed through the skin into the muscles or synovial fluid and an equilibrium state quickly occurs between the skin and muscles or synovial fluid.

With local application of Nise gel, its systemic absorption is insignificant, since the levels of nimesulide in the blood plasma remained below the detection limit of high-performance liquid chromatography, and after 5:00 very low concentrations(100 μg/L) 4-hydroxy-nimesulide in blood plasma.

Indications

For local treatment osteoarthritis (including rheumatoid arthritis), osteoarthrosis, tendovaginitis, bursitis, synovitis, lumbodynia; post-traumatic inflammation of tendons, ligaments, muscles, joints.

Contraindications

Increased sensitivity to the components of the drug dermatitis and infectious diseases of the skin, damage to the epidermis.

Nise gel is contraindicated in patients with acetylsalicylic acid and other non-steroidal anti-inflammatory drugs have caused symptoms of bronchial asthma, urticaria, bronchospasm, rhinitis, Quincke's edema or allergic rashes on the skin.

Proper safety precautions for use

The drug is intended for external use only. It is recommended to apply the gel only to intact areas of the skin, avoid contact with open wounds. Do not use the gel under airtight or tight bandages. Avoid contact of the gel with the eyes and mucous membranes. It is necessary to wash your hands thoroughly before and after using the gel. Close the tube tightly after using the gel.

When applied to large areas of skin, systemic side effects may occur. Therefore, in elderly patients with significant impairment of renal or liver function, patients with congestive heart failure, patients with gastro-duodenal bleeding or severe blood clotting disorders, the drug should be used with caution and under the supervision of a physician.

To reduce the risk of adverse reactions, it is necessary to use the minimum effective dose with shortest duration course of treatment. If the patient's condition does not improve, he should definitely consult a doctor.

The drug should not be used in patients with known hypersensitivity to NSAIDs. If hypersensitivity reactions develop, treatment should be stopped and consult a doctor.

During the treatment period, photosensitivity reactions may develop. To reduce the risk of photosensitivity, patients should avoid UV irradiation and visiting a solarium.

Use during pregnancy or breastfeeding

Not used.

The ability to influence the reaction rate when driving vehicles or other mechanisms

Does not affect.

Children

Not used.

Directions for use and doses

For adults, apply the gel (a column of gel approximately 3 cm long) to the affected area of the body in a thin layer 3-4 times a day, lightly rubbing. Before applying the gel, the skin surface should be thoroughly washed and dried. Therapy may be modified depending on the location of the lesion and the patient's response to treatment. The duration of the course of treatment is determined by the doctor individually depending on the effectiveness of the therapy.

Overdose

Cases of drug overdose have not been described.