Azz and its worthy analogues. Mucolytic drugs Zambon Fluimucil Effervescent tablets What is ACC
Having gone to the pharmacy for ACC long, quite by accident (at the prompt of the pharmacist) I discovered Fluimucil.
The main active ingredient of these two drugs is Acetylcysteine 600 mg. I would like to draw your attention to the fact that Fluimucil costs 2.5 times cheaper than the advertised ACC. For myself, I even found one advantage of Flaimucil, this is its packaging. Each effervescent tablet is packed in a separate cell.
Then, as in the ACC, when opening the package (tube), you unpack and reduce the shelf life of all the tablets at once.
The method of application is no different from the analogue. I also want to note that a big plus of the medicine is that you need to take it only 1 time per day.
The taste is slightly different from ACC. Not better, not worse, quite tolerable.
There is an effect from the application. I can’t say that the effect is grandiose, but after 10 days of use, the cough almost disappeared. Sputum began to depart better, became more liquid. It is important not to forget one nuance, you should not start taking the medicine with a dry cough, since Fluimucil increases the amount of sputum, which is detrimental with a dry cough.
pharmachologic effect
mucolytic drug. The presence of sulfhydryl groups in the structure of the acetylcysteine molecule contributes to the breaking of disulfide bonds of sputum acid mucopolysaccharides, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.
With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.
Pharmacokinetics
Data on the pharmacokinetics of the drug ACC ® Long are not provided.
Indications
- diseases of the respiratory system, accompanied by the formation of viscous sputum difficult to separate: acute and chronic bronchitis, obstructive bronchitis, laryngotracheitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis;
- acute and chronic sinusitis;
- otitis media.
Dosing regimen
Adults and teenagers over 14 years old it is recommended to prescribe the drug at 600 mg (1 effervescent tablet), which corresponds to 600 mg of acetylcysteine per day.
At short term colds the duration of admission is 5-7 days. At long-term illnesses the duration of therapy is determined by the attending physician. At chronic bronchitis the drug should be taken for a longer time to prevent infections.
The drug should be taken after meals.
Additional fluid intake enhances the mucolytic effect of the drug.
Effervescent tablets ACC ® Long should be dissolved in 1 glass of water. Take immediately after dissolution, in exceptional cases, you can leave the finished solution for 2 hours.
Side effect
From the nervous system: rarely - headache, tinnitus.
From the digestive system: rarely - stomatitis; very rarely - diarrhea, vomiting, heartburn and nausea.
From the side of the cardiovascular system: very rarely - a decrease in blood pressure, tachycardia.
Allergic reactions: in isolated cases - bronchospasm (mainly in patients with bronchial hyperreactivity), skin rash, itching and urticaria.
Others: in isolated cases - the development of bleeding as a manifestation of a hypersensitivity reaction.
Contraindications for use
- pregnancy;
- lactation period (breastfeeding);
- children's age up to 14 years;
- Hypersensitivity to the components of the drug.
With caution should be used in patients with peptic ulcer of the stomach and duodenum in the acute phase, with hemoptysis, pulmonary hemorrhage, varicose veins of the esophagus, bronchial asthma, diseases of the adrenal glands, liver and / or kidney failure.
Use during pregnancy and lactation
Due to insufficient data, the use of the drug during pregnancy and lactation is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus or child.
Use in children
Contraindications: children under 6 years of age (preparation in the form of granules for the preparation of a solution for oral administration of 200 mg); children under 14 years of age (dosage forms of the drug containing 600 mg of acetylcysteine).
Overdose
Symptoms: possible diarrhea, vomiting, stomach pain, heartburn, nausea. So far, no severe and life-threatening adverse reactions have been observed.
Treatment: conducting symptomatic therapy.
drug interaction
With the simultaneous use of acetylcysteine and antitussives, due to the suppression of the cough reflex, dangerous mucus stagnation may occur (use the combination with caution).
With the simultaneous administration of acetylcysteine and nitroglycerin, the vasodilating effect of nitroglycerin may be enhanced.
Acetylcysteine reduces the absorption of cephalosporins, penicillins and tetracyclines, so they should be taken orally no earlier than 2 hours after taking acetylcysteine.
Acetylcysteine is pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.
Upon contact of acetylcysteine with metals, rubber, sulfides are formed with a characteristic odor.
Terms of dispensing from pharmacies
The drug is approved for use as a means of OTC.
Terms and conditions of storage
The drug should be stored out of the reach of children, dry, dark place at a temperature not exceeding 30°C. Shelf life - 3 years.
After taking the pill, the tube should be tightly closed.
Application for violations of liver function
The drug follows caution use in liver failure.
Application for violations of kidney function
The drug follows caution use in renal failure.
special instructions
In bronchial asthma and obstructive bronchitis, acetylcysteine should be administered with caution under the systematic control of bronchial patency.
With the development of adverse reactions, the patient should stop taking the drug and consult a doctor.
When dissolving the drug, it is necessary to use glassware, avoid contact with metals, rubber, oxygen, easily oxidized substances.
When treating diabetic patients, it should be taken into account that 1 effervescent tablet ACC Long ® corresponds to 0.01 XE.
Dosage form ACC Long - effervescent tablets: white, round, flat-cylindrical, with a chamfer, on one side there is a risk; with the smell of blackberries and, perhaps, a slight specific smell of sulfur; the reconstituted solution is colorless, transparent, with a blackberry odor and a slight sulfur odor (in polypropylene tubes of 6, 10 or 20 pcs., 1 tube in a cardboard box).
Composition of one tablet:
- active ingredient: acetylcysteine - 600 mg;
- auxiliary components: anhydrous citric acid, blackberry flavor "B", ascorbic acid, lactose, mannitol, sodium bicarbonate, sodium cyclamate, sodium carbonate, sodium saccharinate dihydrate, sodium citrate dihydrate.
Pharmacological properties
Pharmacodynamics
Acetylcysteine - the active substance of ACC Long tablets, which has an expectorant effect, facilitates the discharge of sputum due to the impact on its rheological properties. It is a derivative of cysteine, an aliphatic sulfur-containing amino acid. Acetylcysteine breaks the disulfide bonds of mucopolysaccharide chains, which causes depolymerization of sputum mucoproteins and a decrease in mucus viscosity, and also contributes to better expectoration and discharge of bronchial secretions. The substance retains its effect in the presence of purulent sputum.
Acetylcysteine has antioxidant and pneumoprotective effects due to its binding by reactive sulfhydryl groups of oxidizing radicals and, consequently, their neutralization.
In addition, acetylcysteine contributes to the formation of glutathione, an important component of the body's chemical detoxification and antioxidant system. The antioxidant activity of the substance helps to increase intracellular protection against the negative effects of free radical oxidation, which occurs during an intense inflammatory process.
In the case of prophylactic use of the drug, there is a decrease in the severity and frequency of exacerbations in patients with cystic fibrosis and chronic bronchitis.
Pharmacokinetics
- absorption: acetylcysteine after oral administration is rapidly and completely absorbed. Bioavailability is 10%, due to the pronounced effect of the first passage through the liver. The maximum plasma concentration is reached in 1-3 hours;
- distribution: 50% of acetylcysteine binds to plasma proteins. The substance crosses the placental barrier. There is no information about its ability to penetrate the blood-brain barrier (BBB) and be excreted in breast milk;
- metabolism: acetylcysteine is rapidly metabolized in the liver with the formation of a pharmacologically active metabolite of cysteine, as well as cystine, diacetylcysteine, and then mixed disulfides;
- excretion: acetylcysteine is excreted by the kidneys in the form of inorganic sulfates, diacetylcysteine and other inactive metabolites. The half-life (T 1/2) is determined mainly by rapid biotransformation in the liver and is approximately 1 hour. With a decrease in liver function, T 1/2 increases to 8 hours.
Indications for use
ACC Long is used to treat respiratory diseases that produce viscous sputum that is difficult to separate, including the following:
- acute and chronic form of bronchitis;
- bronchial asthma;
- pneumonia;
- lung abscess;
- tracheitis, laryngotracheitis;
- obstructive bronchitis;
- bronchiectasis;
- cystic fibrosis;
- bronchiolitis;
- chronic obstructive pulmonary disease;
- otitis media (inflammation of the middle ear);
- acute and chronic sinusitis.
Contraindications
Absolute:
- exacerbation of gastric and duodenal ulcers;
- pulmonary bleeding;
- hemoptysis;
- lactose intolerance, lactase deficiency, glucose/galactose malabsorption;
- pregnancy and lactation;
- age up to 14 years;
- increased individual sensitivity to any components of the drug.
Relative (diseases / conditions, the presence of which requires caution when prescribing ACC Long):
- renal/liver failure;
- bronchial asthma;
- obstructive bronchitis;
- stomach ulcer and duodenal ulcer in history;
- varicose veins of the esophagus;
- arterial hypertension;
- diseases of the adrenal glands;
- histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine affects the metabolism of histamine, which can cause signs of intolerance, manifested in the form of vasomotor rhinitis, itching and headache).
ACC Long: instructions for use (dosage and method)
ACC Long is taken orally after a meal. The tablet should first be dissolved in 200 ml of water and taken thereafter without delay. In exceptional cases, it is permissible to store the finished solution for no more than 2 hours. Additional fluid intake enhances the mucolytic effect of the drug.
If there are no other appointments, ACC Long is taken 1 tablet (600 mg) 1 time per day.
For short-term uncomplicated colds, the duration of treatment is 5-7 days. Patients with chronic bronchitis or cystic fibrosis are prescribed a longer course of therapy to prevent infections.
Side effects
The frequency of adverse reactions is assessed on a special scale: very often (more than 1/10), often (more than 1/100, but less than 1/10), infrequently (more than 1/1000, but less than 1/100), rarely (more than 1 / 10,000, but less than 1/1000), very rarely (less than 1/10,000), with an indeterminate frequency (if it is impossible to estimate the frequency based on the available data).
Possible side effects from systems and organs:
- respiratory system: rarely - shortness of breath, bronchospasm (mainly in patients with an increased bronchial response in bronchial asthma);
- digestive system: infrequently - diarrhea, nausea, vomiting, dyspepsia, abdominal pain, stomatitis;
- cardiovascular system: infrequently - tachycardia, lowering blood pressure;
- organ of hearing: infrequently - tinnitus;
- allergic reactions: infrequently - urticaria, exanthema, rash, pruritus, angioedema; very rarely - Stevens-Johnson syndrome, anaphylactic reactions of varying severity (up to shock), Lyell's syndrome (toxic epidermal necrolysis);
- other: infrequently - fever, headache; with an indefinite frequency - a decrease in platelet aggregation, the occurrence of bleeding (manifestation of a hypersensitivity reaction).
Overdose
Symptoms of intentional or erroneous overdose of ACC Long are nausea, vomiting, diarrhea, stomach pain, heartburn.
special instructions
Patients with obstructive bronchitis and bronchial asthma in the appointment of the drug should constantly monitor bronchial patency.
Information for patients with diabetes: one tablet of ACC Long 600 mg contains 0.001 XE (bread units).
In the course of treatment with acetylcysteine, cases of severe allergic reactions, such as Lyell's syndrome and Stevens-Johnson syndrome, were very rarely observed. With the manifestation of changes in the skin and mucous membranes, the patient should immediately stop taking the drug and consult a doctor.
When dissolving an effervescent tablet, glassware should be used. Contact with easily oxidized substances, oxygen, rubber, metal should be avoided.
Use during pregnancy and lactation
According to the instructions, ACC Long is contraindicated in pregnant women due to the lack of data confirming the efficacy / safety of its use in this group of patients.
If necessary, taking the drug during lactation, breastfeeding should be suspended.
Application in childhood
For children and adolescents under 14 years of age, ACC Long 600 mg tablets are contraindicated.
For impaired renal function
In patients with renal insufficiency, the drug should be used under medical supervision.
For impaired liver function
The presence of liver failure requires caution when prescribing ACC Long.
drug interaction
- tetracyclines, penicillins, cephalosporins and other oral antibiotics: their antibacterial activity may be reduced due to a possible interaction with the sulfhydryl group of acetylcysteine. Therefore, the drug and antibiotics should be taken at least 2 hours apart (except for loracarbef and cefixime);
- nitroglycerin and vasodilators: when used simultaneously with acetylcysteine, their vasodilating effect is likely to increase;
- antitussives: sputum stagnation may occur due to suppression of the cough reflex when taken in combination with ACC Long.
Analogues
The analogues of ACC Long are: ACC 100, Fluimucil, ACC 200, Acestine, ESPA-NAC, Acetylcysteine, N-AC-ratiopharm and others.
Terms and conditions of storage
Store in a tightly closed tube, protected from light, moisture and out of the reach of children, at temperatures up to 30 °C.
Shelf life - 3 years.
Cough is a reaction of the body to completely different diseases of the respiratory tract, often of an inflammatory nature. Sometimes it goes away on its own and does not require outside help. But, with a weakened immune system, the cough drags on for a long time, tormenting the patient and giving him a lot of inconvenience.
For the treatment of inflammatory pathologies of the bronchopulmonary system, there are many drugs, one of which is ACC. It is used to treat dry and wet (wet) cough, both in adults and in pediatrics. ACC is a safe and popular remedy that has repeatedly proven its effectiveness in the fight against viscous sputum, but because of its high cost, cheap ACC analogues are becoming popular. Pharmacological affiliation - mucolytic, ATX code: 05CB01.
Main properties, composition and form of release of ACC
Acetylcysteine, the main substance of ACC, has a pronounced anti-inflammatory, expectorant, thinning and antioxidant effect. The main task of the drug is to thin and remove sputum that is difficult to separate from the respiratory tract. Thanks to the cleansing of the bronchi, inflammation is removed, cough is eliminated, and the protective function of the mucosa is restored.
ACC with a dry cough is most in demand, so there is no doubt whether to purchase the drug or not. It is necessary as soon as possible to help the bronchi to be cleared of sticky sputum, which prevents the patient from recovering. Cough is not able to expel such sputum, so mucolytics will be required. ACC and its analogues, cheap or more expensive, allow the bronchopulmonary system to get rid of accumulated mucus and get rid of cough.
For ease of use, the drug is available in different forms. Patients can use effervescent tablets, hot drink (prepared from powder), solution (powder base). One of the latest innovations of Salutas Pharma GmbH (Germany) is ready-made syrup, which is available in bottles of 100 and 200 ml.
In terms of taste, ACC has a variety. There are forms with orange, cherry, lemon and blackberry flavors.
The action of ACC occurs on the first day of admission, and on the second day, patients note that they have wet sputum, and they already have something to expectorate. The feeling of tightness, pain, and other more unpleasant symptoms in the sternum are reduced.
What pathologies are treated with ACC?
The drug is used for all diseases accompanied by the accumulation of viscous, thick and difficult to separate sputum in the bronchi. These pathologies include:
- acute and chronic bronchitis;
- COPD (chronic obstructive pulmonary disease);
- pneumonia;
- bronchial asthma (mild and moderate degree);
- bronchiectasis;
- lung abscess;
- tracheitis and laryngotracheitis;
- cystic fibrosis (a systemic disease in which the secretion of mucus in the body is disrupted);
- sinusitis;
- inflammation of the middle ear.
How to dose the drug correctly?
Depending on the disease, the severity of symptoms and the age of the patient, the dose of ACC may vary.
So with cystic fibrosis, a maximum daily dose of up to 800 mg is allowed, while the patient's body weight should not be less than 30 kg.
Infants (from the third week of life) and babies up to 2 years of age are prescribed up to 150 mg per day, dividing the dose by 50 mg. Children from 2 to 5 years old are allowed to give up to 400 mg per day (we divide the drug into 4 doses). After 6 years, the maximum daily dose increases to 400-600 mg per day, it is also divided (three doses per day).
With uncomplicated cough, the course of treatment for ACC is a week. If necessary (chronic diseases), the drug is used up to 6 months.
ACC is dissolved in a liquid (100 ml), it is better to use water, but you can also use compote, juice, cool tea. Reception is made after meals. Doctors do not advise drinking ACC before bedtime, because. increased sputum flow, even in a horizontal position, can increase coughing. Therefore, the last dose should be immediately after dinner (around 18:00).
Instructions for use ACC prohibits the use of the drug in the following cases:
- intolerance to acetylcysteine and all complementary components;
- severe allergic anamnesis;
- bleeding from the lung tissue;
- tendency to bronchospasm;
- hypotension;
- hemoptysis;
- fructose intolerance;
- ulcerative processes of the gastrointestinal tract;
- hepatitis and more severe kidney disease in children.
Against the background of taking ACC, the following negative reactions are possible:
- a sharp decrease in blood pressure;
- headache;
- the appearance of noise in the ears;
- nausea, diarrhea;
- stomatitis;
- itchy dermatoses;
- tachycardia;
- asthma attack;
- other.
Clinical trials of ACC did not reveal a negative effect of the drug on the fetus, however, it is not recommended to use it at all gestational ages and during breastfeeding.
If the patient is not satisfied with the price or side effects appear, ACC can always be replaced with cheaper analogues, both domestic and foreign. In this case, it is better to use drugs with a different active substance, because. structural analogues are more likely to cause the same undesirable symptoms.
ACC - cheap analogues for children and adults
To determine which analogues will be cheaper, let's first look at some ACC prices:
- orange granules No. 20 - 140 rubles;
- syrup 200 ml - 350 rubles;
- syrup 100 ml - 225 rubles;
- ACC 200 tablets No. 20 - 250-320 rubles;
- ACC long 600 mg effervescent tablets No. 10 - about 400 rubles.
The most popular analogue of ACC is the Swiss drug fluimucil. It is a structural analogue, and has much in common with ACC, even their price is the same.
- You can buy cheaper, for example, acetylcysteine made in Estonia (Vitale-HD). At a lower price, you can also buy Ambrohexal, Ambrobene or the domestic drug Ambroxol. These funds have another active substance - ambroxol.
- Bromhexine is also considered a cheap analogue of ACC. The price for 100 ml of syrup (Russia) is 80 rubles, made in Latvia - 125 rubles.
- Popular, but more expensive analogues are ascoril and lazolvan.
To replace the drug, always contact the specialist who prescribed the cough treatment. If this is not possible, you will have to work a little on your own. To do this, you need to take the instructions for the main drug, in our case it is ACC, and compare it with the intended substitute.
Many instructions already give a hint in the form of a list of potential analogues. The main thing is to pay attention to the list of warnings, indications, as well as age, especially when the child needs therapy. In principle, it is necessary to conduct a comparative assessment, and highlight all the advantages of the analogue.
Which is better - ACC or its analogues? Such a concept has its own relativity, since for one patient, for example, ACC is suitable, and for another, a remedy with a different composition. The clinical picture of the disease, the intake of concomitant medicinal substances, a history of chronic pathologies - all this together affects the exact determination of the desired drug. That is why without a medical education it is not advisable to conduct experiments on yourself and your loved ones.
Comparing drugs, you can only highlight the pros and cons in order to better navigate the choice of analogues, as well as acquire a less toxic and more effective remedy.
ACC - instructions and analogues
ACC or lazolvan - which is better to choose?
The drugs differ in their composition, therefore, they are not structural analogues. The active substance of ACC is acetylcysteine, in lazolvan the main component is ambroxol. Funds are issued by different countries. ACC is produced by companies in Slovenia and Germany, and lazolvan is produced by France, Germany, Spain and Greece.
In terms of the number of dosage forms, lazolvan has an advantage, it has five of them, while ACC has only three.
Both drugs have a pronounced mucolytic effect, i. liquefy sputum, but their mechanism of "work" is different. Unlike lazolvan, ACC also exhibits antitoxic and antibacterial effects.
Sometimes the funds in question are prescribed in parallel. One drug is taken orally, the other is used by inhalation.
In pediatric practice, lazolvan is successfully used from a very early age, and ACC, starting from two years (for cystic fibrosis from birth). Lasolvan is often used for inhalation, so some pediatricians prefer it.
The price of drugs depends not only on the dosage form, but also on the country of manufacture. In general, the funds under consideration are close in price, and may differ within 20%, and in some pharmacies, lazolvan is more expensive, in others, on the contrary, ACC.
What is better ACC or Ambrobene?
The drugs differ in their composition, but they have the same pharmacological affiliation - mucolytics. The active ingredient in Ambrobene is Ambroxol hydrochloride.
Ambrobene's variety of dosage forms (there are five of them) is an advantage over ACC.
According to recent studies, it has been found that it has antiviral activity, has a mild analgesic effect, relieves inflammation, and removes toxins. Studies have also shown that ambroxol hydrochloride slows down the spread of the harmful protein alpha-synuclein, which causes the progression of a severe disease like Parkinson's disease.
Despite the way ACC and Ambrobene act, their main task is the same - to save the patient from thickened sputum.
We also allow the combined use of these funds. This combination is indicated when the disease becomes more serious.
According to the observations of pediatricians, and taking into account the instructions for the preparations, for the smallest patients, including infants, it is better to use ambrobene.
As for the price, let's do a little calculation. For a course of cough treatment with a common viral infection, you will need about 20 tablets of ambrobene. The price for them is 150 rubles. Tablets ACC 200 No. 20 cost about 300 rubles, this amount is also suitable for a course of treatment.
So, we see that the treatment of ACC will cost twice as much. Which is better to choose is up to the doctor and the patient.
ACC or fluimucil - which works better?
The means under consideration are structural analogues, and this suggests that they have the same principle of action. After taking both drugs, the productivity of cough improves markedly by the end of the first day of administration, and after a few days this symptom itself recedes due to the release of sputum and the cleansing of the bronchopulmonary tree.
Firms and countries-manufacturers for drugs are different. Someone prefers the products of Switzerland or Italy (fluimucil), and someone prefers Slovenia and Germany (ACC).
If somewhere you can find significant differences in the presented funds, then these are the forms of release. These funds have different variations not only in the form of release, but also in dosages, which makes it possible to use the medicine at any age. It should be noted right away that according to these criteria, ACC has an advantage.
For example, ACC has a syrup, but fluimucil does not have this form. But fluimucil has a solution for oral administration, inhalation and injection (ACC does not have such forms). More details about all doses and forms are written in the official instructions, where you can more clearly read the information of interest.
Pulmonologists consider it undoubted - this is the use of an agent for inhalation and injection, due to which acetylcysteine gets to its destination faster. This speed of action of the drug is especially important in acute cases of the disease.
Syrups are more popular in children's practice, so it is better for kids to advise ACC in cherry flavored syrup. But, in any case, only a pediatrician selects the right drug for children.
Parents must make sure that the child takes the syrup correctly. It is also important to give patients an alkaline drink to enhance the action of ACC or fluimucil.
Comparing prices, it was noticed that fluimucil in the form of effervescent tablets at a dose of 600 mg would be the cheapest.(about 150 rubles for 10 pieces). The price of ACC for the same dose and number of tablets is much more expensive, and is about 400 rubles. The cost of other forms is not particularly different, fluimucil is literally 10% cheaper.
Bromhexine or ACC?
The drugs are analogues only in therapeutic action. The active substance of bromhexine repeats its name, the drug is classified as a stimulant of the motor function of the respiratory tract and secretolytics.
As well as ACC, Bromhexine affects the secretion of bronchial glands, due to which thick sputum is liquefied. Under the influence of the means under consideration, sputum secretion and its evacuation from the bronchi improves.
The toxicity of ACC is lower, so the list of contraindications is shorter. Bromhexine perfectly suppresses the cough center, and ACC acts on the peripheral cough mechanism. This feature of these funds allows you to prescribe them in a complex, and the effect of treatment is much better than a single dose. The drugs complement each other perfectly.
Despite this possibility, this is not a reason to immediately take ACC and Bromhexine together. It all depends on the clinic of the inflammatory process and the ability of the bronchi to self-cleanse.
All forms of bromhexine are lower in cost, for example, the price of its 100 ml syrup is 100 rubles cheaper than the same syrup from ACC.
ACC or Askoril?
Comparing these drugs, let's pay attention, ACC is a mono drug (the active component is acetylcysteine), and ascoril is a combined remedy, which includes three active substances: bromhexine, guaifenesin and salbutamol.
Even an ordinary person, without a medical education, will understand that ascoril has a more powerful effect, because. supplied with three medicinal substances. In addition to the mucolytic and expectorant effect, ascoril also has a bronchodilator property (relieves spasm of the smooth muscles of the bronchi). Simply put, it relieves the feeling of tightness in the chest (suffocation).
If you look at the offers of pharmacies, then in most cases ascoril and ACC will practically coincide in price. So, for example, the price for a bottle of syrup in 200 ml is approximately 400 rubles for both drugs.
The cardinal difference between the drugs in question is that ascoril is not used for coughing, which is not accompanied by obstruction and asthma attacks.
Conclusion
ACC and its analogues help with both dry and wet cough, and it is up to the doctor to choose a substitute for the active substance or a suitable drug for therapeutic action. Especially unacceptable is the self-administration of drugs such as ascoril, which includes an active substance (salbutamol), which expands the bronchi.
Do not select analogues at your own peril and risk, approaching the choice based only on the price, cheaper does not mean more efficient! Competent appointment - a chance for quick healing! Be healthy!
ACC is a popular drug that is prescribed for a cough accompanied by sputum that is difficult to separate. On pharmacy shelves, the remedy can be found in the form of a powder, syrup, and also effervescent tablets. The cost of the drug depends on the form of release, and is quite high. There are cheaper analogues of ACC, which are not inferior to him in their ability to facilitate the discharge of mucus.
Indications for use and cost
ACC is an effective medicine containing the substance acetylcysteine, has the following properties:
- promotes expectoration of viscous sputum;
- relieves inflammation;
- stimulates the thinning of mucus;
- helps to extract the secret from the respiratory system;
- eliminates toxicity;
- relieves cough;
- restores damaged mucous membranes.
The therapeutic effect can be felt already on the second day of admission. Many patients note the appearance of a wet cough, a decrease in swelling and an improvement in their general condition.
The drug is prescribed for all infectious diseases characterized by difficult-to-separate mucus in the bronchi.
Indications for use are:
- various types of bronchitis;
- lung obstruction;
- pneumonia;
- bronchial asthma;
- sinusitis;
- otitis;
- laryngotracheitis and other diseases.
The drug is allowed to be taken by babies from the third week of life. That is why various forms of release are provided.
- The drug in the form of granules is sold at a price of 122-185 rubles. depending on the number of bags in the package.
- Effervescent tablets Long-600 No. 20 can be purchased at a price of 517 rubles.
- The average cost of syrup is 346 rubles.
Which is better, ACC or similar drugs? It is impossible to answer this question unambiguously, since a certain remedy is suitable for each patient, depending on the severity of the symptoms and the state of health.
What to replace
Most often, patients are looking for a replacement for the drug, having learned its price or when negative effects appear after taking it. In this case, the doctor may recommend an inexpensive analogue of ACC with the same active ingredient or a remedy with a different active ingredient.
You can replace effervescent tablets with other drugs with a similar expectorant effect. These drugs have the same form of release and dosage of 600 mg, but their cost is slightly lower:
- Acetylcysteine, 24 pieces is sold at a price of 233 rubles;
- Fluimucil effervescent tablets, 10 pieces - 138 rubles each;
- Vicks asset Expectomed can be found in online stores from 113 rubles.
Cheap analogues of ACC Long-600 can be purchased at any pharmacy, after notifying the attending physician.
Fluimucil
One of the popular analogues is the Swiss-made medicine Fluimucil, which has the same active ingredient and about the same cost. Effervescent tablets, solution and powder can be bought in the range of 164-446 rubles, depending on the form of release.
The drug promotes the release of purulent mucus, increases the volume of sputum. Can be used by children from 6 years of age.
Which medication to choose, Fluimucil or ACC? After the use of both substances, relief of the condition occurs already on the second day. The difference between drugs is that Fluimucil is additionally produced in the form of a solution for inhalation, ACC - in the form of a syrup. Many prefer the second medicine, since the syrup is more suitable for use in childhood.
Granules and soluble tablets can be purchased at a price of 117-233 rubles.
Other analogues containing the active ingredient acetylcysteine are:
- Mukobene;
- Tussik;
- Mukomist;
- Exomyuk;
- Acestad;
- Acestine.
All medicines have a similar therapeutic effect. Their differences may lie in the auxiliary ingredients and dosages of the active substance.
Cough analogs
On the advice of a doctor, the prescribed medicine can be replaced with another analogue of ACC cough, which will have a similar effect, but may contain a different active ingredient.
Medicines containing ambroxol
Such medicines are not structural analogs of ACC and are produced by different countries. These drugs have a mucolytic effect, thin the mucus, but the mechanism of drug action may differ.
- Lazolvan helps to eliminate bacteria, removes toxins. Can be used from early childhood. It is sold in the form of a solution for inhalation, syrup, tablets and capsules. Price - 170-394 rubles.
- Ambrohexal in the form of a solution, tablets and syrup, also belongs to expectorant drugs. It is used for bronchitis, viral infections and other pathologies of the respiratory system. Side effects include allergic reactions. Significantly cheaper than its counterpart: from 98 to 220 rubles, depending on the form of issue.
- Salbroxol is a mucolytic substance used in bronchitis. It has anti-inflammatory and expectorant properties. The cost is very small - 50-80 rubles.
- Ambrobene is an effective mucolytic that helps eliminate inflammation and swelling in the throat. It can be used in the smallest patients, including infancy. For all forms of release, the cost is quite high.
When choosing a cough remedy, it is important to understand its difference from other drugs. Medicines have either mucolytic or antitussive properties and cannot be taken together.
Medicines containing bromhexine
To facilitate coughing and extract bronchial secretions, products containing the active ingredient Bromhexine will help. These include:
- Solvin. Indications are various pathologies of the lungs, accompanied by viscous sputum. Tablets promote expectoration, have a mucolytic effect, reduce swelling of the mucous membranes. Acceptable for children over 12 years of age.
- Ascoril contains 3 active ingredients - salbutamol, guaifenesin, and also bromhexine. It is used for cough reflexes provoked by acute and chronic bronchopulmonary pathologies with viscous sputum. Relaxes the smooth muscles of the bronchi, prevents spasms, improves the passage of sputum.
- Bromhexine Akrikhin. Increases the volume of mucus, promotes the excretion of sputum. The therapeutic effect is felt after 2-5 days from the start of the intake. Indications are tracheobronchitis, tuberculosis, pneumonia and other diseases of the pulmonary tract.
- Bromhexine Berlin-Chemie. An excellent analogue of ACC for children. It can be prescribed to babies from the age of two. It is intended for the treatment of various bronchopulmonary diseases, accompanied by a viscous secret. It is not recommended in the first trimester of pregnancy, as well as with ulcerative pathologies in the acute stage.
Like acetylcysteine, bromhexine promotes the removal of purulent mucus, thins thick sputum, but the list of restrictions on the use of drugs based on it is much longer. It should be noted that some dosage forms with bromhexine are cheaper in cost than ACC.
Plant based analogues
There are a lot of medicines with plant extracts that stimulate sputum separation and promote the removal of mucus from the respiratory system. The most common are:
- Gedelix syrup contains ivy leaf extract. Despite the high cost, it is very popular with adults and children. Successfully extracts sputum, has an antispasmodic effect.
- Another effective remedy is Prospan syrup. It is used as an additional remedy for exacerbation of inflammatory processes, sore throat. Contains dried raw ivy. The cost of this medicine is quite high.
- Herbion syrup is an effective drug for any kind of cough. Liquefies mucus, eliminates coughing spells, helps reduce shortness of breath, has antispasmodic properties.
ACC and its analogues are taken at the stage of cough transition to wet and productive. Only a specialist should prescribe the necessary medication, based on the examination, diagnosis and complaints of the patient.
The cheapest analogues
On the pharmacy shelves you can find a huge number of drugs, the action of which is aimed at eliminating cough and relieving inflammatory processes. At the same time, drug prices differ significantly.
- The cheapest substitute for ACC is the Russian-made drug Mukaltin. You can buy it for 29 rubles. The active ingredient is Marshmallow officinalis, which promotes mucus discharge and relieves inflammation. It is prescribed for wet cough.
- Another inexpensive drug that thins sputum and extracts it from the respiratory system is Pectusin. The composition includes plant extracts - thyme, thyme, as well as sugar syrup and ethanol. Due to this, it is not used during pregnancy and breastfeeding.
- Bromhexine successfully separates viscous sputum. It is prescribed for bronchitis, asthma, pneumonia. Cost - from 35 rubles.
- A mucolytic drug that successfully relieves a strong cough during pneumonia and tuberculosis is Ambroxol. Ukrainian-made tablets can be purchased at the same price as Mukaltin.
- Pertussin is produced as a sweet syrup. The active ingredient is thyme. It can be prescribed during childbearing and small children. You can buy it at a fairly low cost.
Do not change your prescribed cough medicine on your own. To do this, you must carefully read the instructions for the drug, as well as get advice from a specialist. The doctor will help you choose the right remedy, based on the individual characteristics of the patient and the clinical picture of the disease.