Akriderm Genta application. Cream and ointment Akriderm: instructions, price, reviews and analogues

Akriderm Genta: instructions for use and reviews

Instructions for use. Contraindications and release form.

Instruction
on the medical use of the drug
Akriderm Genta

Dosage form: cream for external use.

Compound: 1 g of cream contains:
active substances: betamethasone dipropionate 0.64 mg and gentamicin sulfate 1 mg;
Excipients: nipagin, propylene glycol, vaseline oil, macrogol cetostearyl ether, cetostearyl alcohol, disodium ethylenediaminetetraacetate, dibasic sodium phosphate, monosubstituted potassium phosphate, purified water.

Description: cream white or almost white.

Pharmacotherapeutic group: aminoglycoside antibiotic + glucocorticosteroid.

ATX code: D07C C01

Pharmacological properties
Combined drug for external use, which has anti-inflammatory, anti-allergic and antibacterial effects.
Betamethasone dipropionate is a glucocorticosteroid that has anti-inflammatory, antiallergic, antiexudative and antipruritic effects. It inhibits the accumulation of leukocytes, the release of lysosomal enzymes and pro-inflammatory mediators in the focus of inflammation, inhibits phagocytosis, reduces vascular tissue permeability, and prevents the formation of inflammatory edema.
Gentamicin is a broad-spectrum antibiotic from the group of aminoglycosides. It has a bactericidal effect against pathogens of primary and secondary bacterial infections of the skin. Active against gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; Gram-positive bacteria: Streptococcus spp. (sensitive strains of beta- and alpha-hemolytic group A streptococcus), Staphylococcus spp. (coagulase-positive, coagulase-negative and some penicillinase-producing strains). Inactive against anaerobes, fungi and viruses.

Indications for use
Dermatitis (simple and allergic), especially secondarily infected, eczema (atopic, childhood, numb), atopic dermatitis (diffuse neurodermatitis), simple chronic lichen (limited neurodermatitis), solar dermatitis, exfoliative dermatitis, radiation dermatitis, diaper rash, psoriasis, itching.

Contraindications
Hypersensitivity to any of the components of the drug, skin tuberculosis, skin manifestations of syphilis, chicken pox, herpes simplex, skin post-vaccination reactions, open wounds, lactation period and children under 1 year of age.

Use during pregnancy and lactation
The safety of topical use of glucocorticosteroids in pregnant women has not been established; the appointment of drugs of this group during pregnancy is justified only if the potential benefit outweighs the possible risk. During pregnancy, drugs in this group should not be used in high doses or for a long time. It has not been established whether topical use of glucocorticosteroids can cause them to appear in mother's milk, so the issue of stopping breastfeeding should be addressed.

Dosage and administration
Outwardly. Akriderm® GENTA is applied in a thin layer to the affected area of ​​the skin 2 times a day - in the morning and in the evening. Other frequency of application can be established by the doctor, based on the severity of the disease. In mild cases, it is sufficient to apply the cream, as a rule, once a day; more severe lesions may require more frequent application.
The duration of treatment depends on the effectiveness and tolerability of therapy and is 2-4 weeks.
If clinical improvement does not occur, the diagnosis should be clarified.

Side effect
With topical application of glucocorticosteroids, there may be observed: burning, irritation, dry skin, folliculitis, hypertrichosis, acne-like rashes, hypopigmentation, perioral dermatitis, allergic contact dermatitis. With prolonged use, as well as the use of occlusive dressings - skin maceration, secondary infection, skin atrophy, prickly heat, purpura. When applied to large surfaces of the body, mainly in children, systemic side effects of glucocorticosteroids (hyperglycemia, glucosuria, reversible inhibition of the function of the adrenal cortex, manifestation of Cushing's syndrome) and gentamicin (nephrotoxic and ototoxic effects) may occur.
If adverse reactions occur that are not described in the instructions, you should consult a doctor.

Overdose
Acute overdose is unlikely, however, with excessive or prolonged use of the drug, chronic overdose is possible, accompanied by signs of hypercortisolism: hyperglycemia, glucosuria, reversible inhibition of the function of the adrenal cortex, manifestation of Cushing's syndrome.
Treatment. Appropriate symptomatic treatment is indicated. In case of chronic toxic effects, gradual withdrawal of the drug is recommended.

Interaction with other drugs
The interaction of the drug with other drugs has not been identified.

special instructions
If there are signs of hypersensitivity or skin irritation associated with the use of the drug, treatment should be discontinued and the patient should be given adequate therapy. With prolonged treatment, when applying the drug to large surfaces of the skin, when using occlusive dressings, as well as in children, systemic absorption of glucocorticosteroids is possible. For children from 1 year of age, the drug is prescribed only according to strict indications and under medical supervision, since the development of systemic side effects associated with betamethasone is possible. When using the drug on large surfaces and / or under an occlusive dressing, it is possible to suppress the function of the hypothalamic-pituitary-adrenal system and develop symptoms of hypercortisolism, there may be a decrease in growth hormone excretion, an increase in intracranial pressure. On the skin of the face more often than on other surfaces of the body, after prolonged treatment with topical glucocorticosteroids, atrophic changes may occur; the course of treatment in this case should not exceed 5 days. Akriderm® GENTA is not intended for use in ophthalmology. Avoid getting the drug in the eyes.
With prolonged use of the drug, its withdrawal should be carried out gradually.

Skin diseases occur for various reasons and cause a lot of inconvenience to a sick person. However, modern drugs are able to cope with the problem in a short time. Akriderm Genta medicine is an ointment or cream that relieves the symptoms and cause of allergies and inflammation on the skin, and also destroys bacteria. The medicine is created on a hormonal basis, and is applied externally.

Akriderm Genta composition

The ointment is used to treat a variety of skin conditions, ranging from allergic reactions to inflammation caused by infections. Due to the content of the hormone glucocorticosteroid, which has a narrowing effect on blood vessels, and the antibiotic gentamicin sulfate, Akriderm reduces itching of the skin, relieves inflammation and has an antibacterial effect. The ointment, due to its composition, is able to cure certain gram-positive bacteria and streptococcus. Also in the composition of the ointment is present:

• water;
• nipagin;
• sodium and potassium phosphate;
• disodium ethylenediaminetetraacetate;
• petrolatum;
• macrogol ether;
• cetostearyl alcohol;
• and propylene glycol.

Ointment Akriderm Genta

Most often, this type of drug is used to get rid of dermatitis, as it relieves itching well, due to the content of betamethasone in it. The color can be either yellow or white. Also, this type of drug has an excellent effect on blood vessels, narrowing them, which reduces redness and permeability, and also reduces the level of mediators that inflame the affected area of ​​the skin. Moreover, it reduces the activity of hyaluronidase. The product has little absorption when used externally. For the effective use of Akriderm Genta ointment, you need to pay attention to the additions to the name:

1. The Ghent prefix is ​​used to treat infections caused by bacteria.
2. Akriderm GK is used for the appearance of lesions caused by a fungus.
3. Akriderm SK must be bought if you have hyperkeratosis.
4. Akriderm without prefix is ​​most often used in the treatment of lesions caused by allergies.

Cream Akriderm Genta

The drug is also available in the form of a cream. The main composition does not differ from the ointment, and they have no difference in purpose. However, Akriderm Genta cream still has slight differences in the components, and more precisely, it contains liquid paraffin, petroleum jelly, etc. Therefore, for dry and flaky lesions, it is better to use an ointment. And the cream is suitable for those who suffer from moist skin wounds.

Indications for use

As mentioned earlier, the use of Akriderm Genta is necessary in case of an allergy, as well as:

• lichen;
• with the formation of diaper rash;
• itching;
• varicose veins;
• children's eczema in the form of a coin;
• psoriasis;
• and dermatitis.

Instructions for use

To avoid side effects when using the drug, you must strictly follow the instructions:

1. The ointment is applied only to the affected area.
2. The damaged area must be treated twice a day in the morning and evening.
3. Apply the drug in a circular motion, trying not to injure the area.
4. Instruction Akriderm Genta pays special attention to the area of ​​​​the feet and palms, as they most often come into contact with various surfaces. In this case, the ointment should be used more often.
5. Do not use the remedy for more than 1 month, as this may adversely affect the level of sensitivity of the affected area.
6. Moreover, if the affected areas are the groin, armpits or perianal area, in order to avoid the development of striae, it is necessary to use the ointment very carefully.
7. Avoid getting ointment and cream in the eyes or on the eyebrows.
8. Also, for a better result, you can put an occlusive dressing on top, unless the skin area is large.

Contraindications

Any medicines have a specific list, according to which it cannot be used. Akriderm contraindications are as follows:

• feeding;
• children under 2 years old;
• skin tuberculosis;
• a skin infection caused by a virus;
• rosacea;
• perioral dermatitis;
• open wounds;
• chickenpox;
• an allergic reaction to the components of the drug;
• herpes vulgaris;
• period of vaccination and post-vaccination;
• syphilis in skin manifestations.

Pregnant women should also use this drug with caution. It is strongly recommended to do this under the supervision of a doctor who keeps a history of a woman during gestation.

An excellent remedy for the treatment of thrush is the drug Nystatin. This is an excellent drug that surpasses its counterparts in many ways.

Side effect

Most often, the use of Akriderm does not cause any side effects. In rare cases, you may experience itching, burning, or pigment loss on the skin. However, if you use the dressings described above, some difficulties may lie in wait here, for example:

• the appearance of acne;
• the skin at the site of the lesion may become dry;
• the occurrence of repeated signs of infection;
• skin miceration;
• dermatitis;
• prickly heat;
• and etc.

Side effects of Akriderm Genta may occur if it is used together with nephro- and toxic agents. This may lead to:

• hearing loss due to trauma to the auditory nerve;
• poor functioning of the vestibular apparatus.

Also, if you use the drug for a long time, you may experience:

• exacerbation of infections that were hidden;
• high blood pressure;
• increased excitability;
• increase in body weight;
• osteoporosis;
• hyperglycemia;
• the occurrence of swelling;
• sleep problems.

Children may experience the following symptoms:

• increased pressure inside the skull;
• hyperglycemia;
• growth retardation;
• glycosuria;
• occurrence of Cushing's syndrome.

Thanks

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Names, varieties, forms of release and composition of Akriderm

Currently, four varieties of Akriderm are produced, such as:

• Akriderm - ointment and cream;
• Akriderm Genta - ointment and cream;
• Akriderm GK - ointment and cream;
• Akriderm SK - ointment.

Ointment and cream Akriderm As an active ingredient, they contain only betamethasone - a glucocorticoid hormone. Moreover, the ointment is produced in only one concentration - 0.05%, and the cream - in two: 0.064% and 0.05%.

Ointment and cream Akriderm Genta have exactly the same composition and concentration of active ingredients, such as: betamethasone - 0.64 mg per 1 g and gentamicin - 1 mg per 1 g. That is, Akriderm Genta ointments and creams contain the glucocorticoid hormone betamethasone and the antibiotic gentamicin as active ingredients . The concentration of ointment and cream is determined by the content of betamethasone and is, respectively, 0.064%.

Ointment and cream Akriderm GK also have exactly the same composition and concentration of active ingredients. So, the composition of creams and ointments Akriderm GK as active ingredients includes the following:

• betamethasone - 0.64 mg per 1 g;
• gentamicin - 1 mg per 1 g;
• clotrimazole - 10 mg per 1 box.

Ointment Akriderm SK as active ingredients it contains betamethasone 0.064 mg per 1 g and salicylic acid 30 mg per 1 g. That is, Akriderm SK ointment contains betamethasone and keratolytic salicylic acid. The concentration of the ointment is traditionally indicated by the amount of betamethasone and, accordingly, is 0.064%.

Cream ointments of each Akriderm variety differ from each other only in the composition of auxiliary components and physical properties (consistency, density, fat content, etc.). Accordingly, ointments and creams are intended for application to skin affected by the same diseases, but in a different state.

What is Akriderm (therapeutic action) for?

Betamethasone, which is part of all varieties of Akriderm, is a glucocorticoid hormone with the following therapeutic effects:

• Anti-inflammatory;
• Antiallergic;
• Anti-exudative;
• Decongestant;
• Antipruritic.

Akriderm should be used in short courses, which are necessary to eliminate severe inflammation, swelling and itching, as well as to stop a dangerous allergic reaction. After inflammation and allergies are significantly reduced under the action of Akriderm, it is necessary to stop using it and switch to the use of other means necessary to completely cure the existing disease. That is, Akriderm ointment and cream are a kind of emergency drugs in difficult situations.

Gentamicin, which is part of the Akriderm Genta variety along with betamethasone, is a broad-spectrum antibiotic that is detrimental to various bacteria. This means that Akriderm Genta, in addition to the indicated effects of betamethasone, additionally has an antibacterial effect, destroying pathogenic bacteria that provoke infectious and inflammatory processes on the skin. Therefore, Akriderm Genta ointment and cream are designed to stop severe inflammatory processes and allergic reactions complicated by the addition of a bacterial infection (pustules, acne, etc.).

Salicylic acid, which is part of Akriderm SK in combination with betamethasone, is a keratolytic, that is, it helps to exfoliate dead cells of the upper layer of the epidermis. Since many skin diseases are accompanied by hyperkeratosis, that is, its thickening and coarsening, the use of a keratolytic, which can remove excess dead keratinized cells, eliminates this condition. Accordingly, Akriderm SK ointment has powerful anti-inflammatory and anti-allergic effects provided by betamethasone, and in addition to them - keratolytic. Thus, Akriderm SK is optimal for use in severe inflammation or allergies in areas of the skin with hyperkeratosis.

Summarizing, we can briefly indicate why each type of Akriderm is needed:

• Akriderm - severe inflammation or an allergic reaction on the skin;
• Akriderm Genta - a severe inflammation or allergic reaction on the skin in combination with a bacterial infection;
• Akriderm GK - a severe inflammation or allergic reaction on the skin in combination with a fungal infection;
• Akriderm SK is a severe inflammation or allergic reaction in areas of the skin with hyperkeratosis.

Indications for use

Ointment and cream Akriderm

• Contact dermatitis with any nature of the course (acute, subacute, chronic);
• Occupational dermatitis;
• Seborrheic dermatitis;
• drug dermatitis;
• Atopic dermatitis (diffuse neurodermatitis);
• solar dermatitis;
• Dyshidrotic dermatitis;
• Toxic dermatitis;
• contact dermatitis;
• Intertrigo;
• Photodermatitis;
• Intertriginous dermatitis;
• Neurodermatitis;
• Skin itching;
• Eczema.

• exfoliative dermatitis;
• radiation dermatitis;
• Simple chronic lichen (limited neurodermatitis);
• Scabies Hyde;
• Prurigo;
• Gluteal dermatitis.

Ointment and cream Akriderm Genta

• Simple dermatitis;
• allergic dermatitis;
• Eczema;
• solar dermatitis;
• exfoliative dermatitis;
• radiation dermatitis;
• diaper rash;
• Itching of the skin with infected scratches and wounds.

Ointment and cream Akriderm GK

• Pemphigus;
• Lyell's syndrome;
• Psoriasis;
• During's disease;
• vesicular dermatitis;
• contact dermatitis;
• Toxidermia.

Ointment Akriderm SK

• Psoriasis;
• Simple chronic lichen (limited neurodermatitis);
• Atopic dermatitis (diffuse neurodermatitis);
• Lichen planus;
• Eczema;
• Dyshidrotic dermatitis;
• Ichthyosoform changes.

Akriderm - instructions for use

What to use, ointment or cream - the rules for choosing a dosage form and variety of Akriderm?

Having chosen the necessary variety of Akriderm, it is necessary to decide which dosage form - cream or ointment is better to use in this particular case. So, creams of any kind of Akriderm are recommended for application to wet and weeping surfaces of the skin, for example, to wounds with abundant discharge, etc. Ointments of any kind of Akriderm are optimal for application to dry skin with scales and peeling. Of course, if necessary, if it is not possible to acquire the optimal form of Akriderm (ointment or cream), you can replace the cream with ointment and vice versa. However, it is better to follow the recommendations and apply a cream for wet skin, and an ointment for dry skin.

Akriderm, Akriderm Genta, Akriderm GK and Akriderm SK - instructions for use

So, an ointment or cream is applied with a thin layer to the affected area of ​​​​the skin 2 to 6 times a day. The ointment or cream is gently rubbed into the skin with light massaging movements, and then left for a few minutes for complete absorption. To enhance the therapeutic effect, a tight or occlusive bandage can be applied over the ointment or cream, and left until the next application of the drug. If a large area of ​​skin is being treated (more than 10 cm X 10 cm), then occlusive or tight dressings cannot be applied, since this increases the risk of absorption of a large amount of cream or ointment into the blood and the appearance of systemic side effects of glucocorticoids.

A tight bandage is an application of a sterile napkin to the area of ​​\u200b\u200bthe skin treated with Akriderm ointment or cream, which is wrapped with a sterile bandage. For an occlusive dressing, a piece of polyethylene or other moisture- and air-tight material (such as rubber, etc.) must be placed on top of the cream or ointment. This piece of air- and moisture-impermeable material is fixed with a tight bandage from a sterile bandage.

In the vast majority of cases, it is enough to apply an ointment or cream twice (morning and evening) to the skin to achieve a good therapeutic effect. However, if the inflammation is very strong and the morning application of a cream or ointment is not enough to provide a therapeutic effect until the evening, then the drugs can be used up to 6 times a day. In addition, more than twice a day, it is recommended to apply Akriderm creams or ointments to those areas of the skin from which they are quickly erased, for example, on the feet, fingers and toes, etc. If the disease proceeds with mild severity, then the ointment or cream of any kind of Akriderm can be applied only once a day, in the morning.

The duration of treatment with ointments or creams of any kind of Akriderm is on average 2 to 4 weeks. Preparations can be used for less than two weeks if the result was achieved faster. That is, any kind of Akriderm can be used until the desired clinical effect is achieved (for example, complete suppression of inflammation and itching, etc.), but not longer than 4 weeks. However, when applying Akriderm to the face, the duration of therapy should not exceed five days.

If after 2 weeks of continuous use of any variety of Akriderm there is no clinical improvement, you should consult a doctor for additional examination, clarification of the diagnosis and appointment of another treatment.

It is impossible to use Akriderm ointments and creams for longer than 4 weeks, as this can provoke addiction and withdrawal syndrome due to the presence of glucocorticoid hormone in the preparations. When using Akriderm for more than 3 weeks, the drug should be discontinued gradually. To do this, it is recommended to first halve the amount of cream or ointment applied to the skin for two days, leaving the same frequency of use (for example, 2, 3 times a day). Then on the third day cancel one application of the cream or ointment on the skin. After another two days, the amount of cream or ointment used for application is again halved. Two more days later, one application of the product to the skin is canceled, etc.

If, after using ointments and creams of any kind of Akriderm, side effects or signs of irritation on the skin appear, then you should stop using the drug and consult a doctor to select another drug necessary to treat the existing problem.

When using Akriderm ointments and creams for a long period of time or when applied to large areas (more than 10 cm X 10 cm), betamethasone may be absorbed into the bloodstream in relatively high dosages, which ensure the appearance of systemic effects of glucocorticoids. That is, if Akriderm is used for a long time or applied to large areas of the skin, then the person will have such effects of betamethasone, as if he had taken it orally in the form of tablets or injected (intravenously or intramuscularly). In addition, when using Akriderm Genta and Akriderm GK for a long time or on large areas of the skin, not only betamethasone, but also gentamicin or clotrimazole, respectively, can be absorbed into the blood, which also provokes the development of systemic side effects of this antibiotic and antifungal agent. In the case of Akriderm Genta, the most severe systemic side effect of gentamicin absorbed into the bloodstream is hearing loss.

In young children older than one year, any kind of Akriderm should be used only if indicated, under the supervision of a physician and for the shortest possible time, since they have a very high risk of developing systemic effects of glucocorticoids due to the absorption of betamethasone in a high dosage relative to the body weight of the child. In addition, in children under 7 years of age, when using any kind of Akriderm, tight or occlusive dressings should not be used, since this will increase the absorption of betamethasone into the blood and significantly increase the risk of developing systemic side effects of glucocorticoids, such as suppression of the hypothalamic-pituitary-adrenal system with the formation of hypercortisolism, as well as an increase in intracranial pressure and a decrease in the production of growth hormone.

Creams and ointments of any kind of Akriderm cannot be used in ophthalmic practice, therefore, when using them, it is necessary to avoid getting the compositions into the eyes. If the ointment or cream accidentally gets into the eyes, they should be rinsed with plenty of clean running water and consult a doctor. In addition, it should be remembered that when applying Akriderm creams and ointments to areas with thin skin, for example, in the area around the anus, armpits and in the inguinal fold, stretch marks (stretch marks) may form. Therefore, in these areas, it is recommended to use Akriderm for the shortest possible time.

Do not use creams and ointments Akriderm for the treatment of trophic ulcers of the lower leg, open wounds and varicose veins. Against the background of the use of ointments and creams of any kind of Akriderm, it is recommended to refuse to perform prophylactic scheduled and emergency vaccinations.

Use during pregnancy and breastfeeding

Since it is not known whether betamethasone and other active components of the Akriderm species penetrate into milk, then during the period of use of the drugs, breastfeeding of the baby should be abandoned and transferred to artificial mixtures.

Influence on the ability to control mechanisms

Overdose

• Hyperglycemia (increased blood glucose levels);
• Glucosuria (the appearance of glucose in the urine);
• Cushing's syndrome (weight gain, fat deposition on the face and abdomen, etc.);
• Increased blood pressure;
• Edema.

Interaction with other drugs

Side effects of Akriderm

So, betamethasone as part of all forms of Akriderm has the following side effects:

• Burning on the skin;
• Skin irritation;
• Dry skin;
• Hypertrichosis (excessive growth of body hair);
• acne-like rashes;
• Hypopigmentation (areas of lighter colored skin)
• perioral dermatitis;
• Pyoderma (pustular skin lesions);
• Skin maceration;
• Skin atrophy;
• Erythema (reddening of the skin);
• Purpura;
• Stretch marks (stretch marks);
• Telangiectasia (vascular "asterisks");
• Secondary infection of the skin;

• Hyperglycemia (increased blood glucose levels);
• Glucosuria (sugar in the urine);
• Ulceration of the mucous membrane of the digestive tract;
• Weight gain;
• Increased blood pressure;
• swelling;
• Exacerbation of latent chronic infections;
• Excitation;
• Violation of the menstrual cycle;
• Paresthesia (disturbances of sensitivity by type