Actovegin injection solution - instructions for use. Actovegin in ampoules: instructions for use Actovegin instructions for use contraindications

), Actovegin has an antihypoxic (improves the utilization of oxygen by the body) effect, which manifests itself 30 minutes after parenteral administration, reaching a maximum after 2-6 hours.

Parenteral administration of drugs is a method of introducing drugs into the body, in which they bypass the gastrointestinal tract. Parenteral administration of the drug is carried out using injections (injections in ampoules) and infusion therapy (intravenous administration of a solution for infusion).

Actovegin has an antihypoxic, antioxidant, wound-healing effect, stimulates the processes of functional metabolism (metabolism in the body) and anabolism (absorption of substances by the body). The drug improves blood microcirculation in the vessels of the legs, starting the process of tissue regeneration when their nutrition suffers from damage to the veins (chronic venous insufficiency, thrombophlebitis, varicose veins).

Actovegin increases the concentration of phosphocreatine (creatine phosphoric acid), adenosine diphosphate (ADP), adenosine triphosphate (ATP), amino acids gamma-aminobutyric acid, aspartate (aspartic acid), glutamate (glutamic acid).

Actovegin is used for diseases of the heart and blood vessels, lesions of the central nervous system, for injuries, ulcers. The versatility of the remedy is due to the fact that Actovegin increases the transport of glucose and oxygen to the cells of organs, enhancing their energy resources, increasing functional abilities and survival in conditions where oxygen supply is insufficient and cells are unable to fully function. By facilitating the active entry of glucose into cells, Actovegin has an effect. The agent is an important component of the therapy of patients with diabetes mellitus, including the treatment of diabetic polyneuropathy (DPN).

Diabetic polyneuropathy is characterized by damage to the human nervous system, develops in people suffering from diabetes mellitus due to consistently elevated blood sugar (glucose) (hyperglycemia). The most significant mechanisms for the development of DPN are ischemia and metabolic disorders in the nerve.

The use of Actovegin reduces the symptom of DPN in the form of paresthesia (burning, tingling, crawling, numbness in the lower extremities).

Taking Actovegin helps to reduce sensitivity disorders, improve the mental well-being of the patient.

The duration of the course of treatment with Actovegin is determined by the doctor individually according to the symptoms and severity of the disease.

Anatomical Therapeutic Chemical Classification (ATC)

Anatomical-therapeutic-chemical classification (anatomical-therapeutic-chemical, ATC) is an international classification system for medicines. The main purpose of ATC is to provide statistical data on the consumption of medicines.

According to the ATC, Actovegin drugs, depending on the form of release, belong to the following groups:

Tablets (dragged), solution for infusion, solution for injection in ampoules - B06AB Other blood preparations,
Gel, creams and ointments for external use - D11AX Other preparations for the treatment of skin diseases,
Eye gel - S01X Other drugs for the treatment of diseases of the eyes (currently not assigned a code).

Pharmacological group

Actovegin, a drug that activates tissue metabolism, improves trophism and stimulates the regeneration process, belongs to the following pharmacological groups, depending on the form of release.

Actovegin tablets, infusion solution and injection solution in ampoules:

angioprotectors and microcirculation correctors,
regenerants and reparants.

At the molecular level, Actovegin promotes an increase in oxygen consumption and utilization (increases resistance to hypoxia), increases energy metabolism and glucose consumption.

Nosological classification (ICD-10)

The Tenth Revision International Classification of Diseases (ICD-10) is a standard assessment tool in the field of health management, medicine, epidemiology, and analysis of the general health of the population. According to ICD-10, the drug Actovegin, depending on the form, can be used for the following diseases and conditions.

Actovegin coated tablets:

F03 Dementia, unspecified
I73 Other peripheral vascular diseases,
S06 Intracranial injury.

Actovegin gel, cream and ointment for external use:

L90.8 Other atrophic changes in skin
L98.4 Chronic skin ulcer, not elsewhere classified
L98.4.2* Skin ulcer, trophic,
T14.0 Superficial injury of body region unspecified
Z100* CLASS XXII Surgical practice.

Infusion solution and injection solution in ampoules Actovegin:

I63 Cerebral infarction,
I25.2 Past myocardial infarction,
I67.9 Cerebrovascular disease, unspecified
I69 Sequelae of cerebrovascular diseases,
I73.9 Peripheral vascular disease, unspecified
I79.2 Peripheral angiopathy in diseases classified elsewhere
I87.2 Venous insufficiency (chronic) (peripheral)
I99 Other and unspecified disorders of the circulatory system,
L58 Radiation dermatitis, radiation,
L89 Decubital ulcer (traumatic ulcer, bed sore),
L98.4.2* Skin ulcer, trophic,
S06 Intracranial injury,
T14.1 Open wound of body region unspecified
T30 Thermal and chemical burns, unspecified
T79.3 Post-traumatic wound infection, not elsewhere classified

The term "specified" disease (condition) is used in cases where the doctor has a complete package of medical documents that allow the most objective assessment of the development of the disease (condition). In a situation where this set of documents is missing, and it is impossible to determine the course of the disease by the state of the internal organs, the diagnosis is made. unspecified».

Composition Actovegin

As part of the drug Actovegin, as an active substance, there is deproteinized hemoderivative of calf blood, obtained by means of ultrafiltration (compounds with a molecular weight of less than 5000 daltons pass), containing exclusively physiological substances.

1 tablet (dragee) contains 200 mg,
1 gram of gel for external use contains 8 mg,
1 gram of topical cream contains 2 mg,
1 gram of ointment for external use contains 2 mg,
1 ml solution for injection contains 40 mg,
1 ml solution for infusion contains 4 mg (in a 10% solution) or 8 mg (in a 20% solution),
1 gram of eye gel contains 8 mg.

Auxiliary substances in the composition tablets Actovegin are:

magnesium stearate,
povidone-K90,
talc.

As part of shells Actovegin tablets additionally present:

mountain glycol wax,
gum arabic (acacia gum),
diethyl phthalate,
dye quinoline yellow varnish aluminum,
macrogol-6000,
titanium(IV) oxide (titanium dioxide),
povidone-K30,
sucrose,
talc,
hypromellose phthalate.

The composition of the cream for external use additionally contains benzalkonium chloride 0.2 mg per 1 gram of the drug.

Auxiliary substances in the composition of the infusion solution of Actovegin and the drug in the form of ampoules with a solution for injection are sodium chloride and water for injection. The solution for infusion in a dextrose solution additionally contains dextrose.

Release form and dosage Actovegin

The drug Actovegin is available in the form of tablets (pellets), gel, cream, ointment, ampoules for injection, solution for infusion, ophthalmic gel.

Actovegin coated tablets (dragees):

tablets in a bottle of 200 mg, No. 10,
tablets in a bottle of 200 mg, No. 30,
tablets in a bottle of 200 mg, No. 50,
tablets in a bottle of 200 mg, No. 100.

Packing of tablets (drops) includes:

bottle (vial) of dark glass with a screw neck, sealed with an aluminum cap with first opening control, containing round biconvex shiny tablets coated with greenish-yellow color,
a cardboard pack with a pasted transparent protective sticker of a round shape with holographic inscriptions and control of the first opening.

Actovegin gel for external use:

gel in a tube 20%, 20 grams,
gel in a tube 20%, 30 grams,
gel in a tube 20%, 50 grams,
gel in a tube 20%, 100 grams.

Gel packaging includes:

aluminum tube containing the gel,
instructions for medical use,
cardboard pack.

Actovegin cream for external use:

cream in tube 5%, 20 grams,
cream in tube 5%, 30 grams,
cream in a tube 5%, 50 grams,
cream in tube 5%, 100 grams.

Cream packaging includes:

an aluminum tube containing a cream of constant white color, with no taste and smell,
instructions for medical use,
cardboard pack.

Actovegin ointment for external use:

ointment in a tube 5%, 20 grams,
ointment in a tube 5%, 30 grams,
ointment in a tube 5%, 50 grams,
ointment in a tube 5%, 100 grams.

Ointment packaging includes:

an aluminum tube containing a constant white ointment with no taste and smell,
instructions for medical use,
cardboard pack.

Actovegin solution for injections in ampoules (injections):

solution for injection 80 mg (40 mg/ml, 2 ml ampoule),
solution for injections 200 mg (40 mg/ml, 5 ml ampoule),
solution for injection 400 mg (40 mg/ml, 10 ml ampoule).

Ampoule packaging includes:

Actovegin solution for infusions:

solution for infusion in sodium chloride solution 0.9% 1000 mg (4 mg / ml, 250 ml),
solution for infusion in sodium chloride solution 0.9% 2000 mg (8 mg / ml, 250 ml),
solution for infusion in dextrose solution 1000 mg (4 mg/ml, 250 ml).

Solution packaging for infusion includes:

a colorless glass bottle (type II according to the European Pharmacopoeia) with a transparent, colorless to slightly yellow solution, corked with a cork and an aluminum cap for running in, closed on top with a lid that provides control of the first opening,
instructions for medical use,
a cardboard pack with a pasted transparent protective sticker of a round shape with holographic inscriptions and control of the first opening.

Actovegin eye gel:

gel for instillation into the eyes 20%, 5 grams.

Eye gel packaging includes:

aluminum tube containing ophthalmic gel,
instructions for medical use,
cardboard pack.

At the moment, Actovegin ophthalmic gel to Russia not supplied.

The most common forms of release and dosage of Actovegin found in pharmacies:

Tablets number 50,
Solution in 80 mg ampoules (40 mg / ml, 2 ml ampoule),
Ointment 5%, 20 grams,
Gel 20%, 20 grams.

pharmachologic effect

The pharmacological action of Actovegin is metabolic, which consists in accelerating the processes of oxygen and glucose utilization at the molecular level, thereby increasing resistance to hypoxia. The drug Actovegin has a wound-healing effect, enhances the energy state of the cell, improves blood circulation in tissues.

Indications for use Actovegin

Actovegin is indicated for use in the following diseases and conditions:

Actovegin solution for injection in ampoules and solution for infusion in sodium chloride solution additionally indicated for diabetic polyneuropathy.

Actovegin ophthalmic gel is indicated for lesions and eye diseases:

in case of damage (burns with alkali, acid) of the cornea (cornea) and sclera (protein coat),
with corneal ulcers of various etiologies,
with keratitis (inflammation of the cornea), including after corneal transplantation,
with corneal abrasion in patients using contact lenses,
in order to prevent lesions, when choosing contact lenses in patients with ongoing dystrophic processes in the cornea.

Contraindications Actovegin

The main contraindication to the use of Actovegin is hypersensitivity to the components of the drug.

Other contraindications to taking Actovegin are:

anuria (lack of urine flow to the bladder),
oliguria (reduced amount of urine excreted by the kidneys),
decompensated heart failure II and III degree,
pulmonary edema,
fluid retention in the body.

Actovegin should be taken with caution in patients with hyperchloremia (increased content of chlorine compounds in the blood) and hypernatremia (increased concentration of sodium in the blood plasma).

For Actovegin solution for infusion in a dextrose solution, an additional contraindication is diabetes mellitus - 1 vial of the drug contains 7.75 g of dextrose.

During pregnancy and lactation, the drug should be taken with caution.

Side effects of Actovegin

Side effects from taking Actovegin are extremely rare and are mainly due to hypersensitivity to the components of the drug.

Side effects of Actovegin include possible allergic reactions (, skin rash, hyperthermia (fever), up to. In such situations, treatment with Actovegin should be stopped, if necessary, use and / or.

In severe anaphylactic reactions, emergency therapy should be carried out (administer plasma substitutes, large doses, corticosteroids).

When using a gel, ointment or cream, side effects are possible in the form of itching and burning in the area of application of the drug.

At the beginning of treatment with Actovegin gel, side effects may occur in the form of local pain due to increased secretion. This side effect is not evidence of drug intolerance.

When using the eye gel, lacrimation, injection (redness) of the vessels of the sclera is possible.

If adverse reactions occur, you should stop taking Actovegin, contact a qualified medical specialist, a doctor.

Overdose of Actovegin

To date, there has been no information on an overdose of Actovegin.

Tablets Actovegin (dragee)

Actovegin tablets (pellets) are used orally (by mouth) as maintenance therapy for disorders of cerebral metabolism and circulation, to continue infusion or injection treatment for disorders of cerebral circulation.

The instruction on Actovegin tablets

Reading these instructions for the use of Actovegin tablets does not exempt the patient from studying "Instructions for the medical use of tablets (pellets) Actovegin"

Dragee should be taken orally (by mouth) before meals, without chewing, with a small amount of water.

1-2 tablets three times a day.

The duration of treatment should be 4 to 6 weeks.

The drug begins to act 30 minutes after ingestion, the maximum effectiveness occurs after 3-4 hours: the heaviness in the legs decreases, pain, tingling, numbness of the lower extremities disappear. Children and adolescents should take one tablet of Actovegin once a day, treatment continues for 28-42 days.

The frequency of taking Actovegin tablets may vary depending on the clinical picture and the severity of the disease, determined by the doctor.

Gel Actovegin

Gel Actovegin is a soft form of a drug with a viscous consistency, plasticity, elasticity, and a pH close to the pH of the skin. The gel is evenly and quickly distributed over the surface of the skin without clogging the pores.

Actovegin gel is applied topically under the following circumstances and pathologies:

Actovegin gel is also used for the prevention and treatment of bedsores.

Instructions for Actovegin gel

Reading these instructions for the use of Actovegin gel does not exempt the patient from studying "Instructions for the medical use of Actovegin gel" in the manufacturer's carton.

When treating open wounds and ulcers, Actovegin gel should be applied in a thin layer to the affected areas 5-6 times a day.

When performing pre-treatment to clean ulcerative lesions, the gel must be applied in a thick layer, covering Actovegin ointment with a compress, or with a gauze bandage soaked in ointment (to prevent sticking to the wound). The bandage should be changed once every 24 hours, in the treatment of heavily weeping surfaces - 3-4 times a day. Further treatment should be continued with Actovegin in the form of a cream; treatment should be completed with Actovegin in the form of an ointment.

For burns and radiation injuries, the gel should be applied to the skin in a thin layer.

In the treatment of radiation injuries in patients, the remedy is used in the form of applications.

For the prevention and treatment of bedsores, Actovegin gel must be used 3-4 times a day, the course of treatment is from 3 to 60 days.

The frequency of application of the gel may vary depending on the clinical picture and the severity of the disease, determined by the doctor.

Cream Actovegin

Actovegin cream is applied topically under the following circumstances and pathologies:

with ulcers of varicose origin, weeping ulcers,
with wounds and inflammation of the skin and mucous membranes, burns, skin cuts, scratches, abrasions,
in order to promote tissue regeneration after burns,
during pre-treatment of wound surfaces before transplantation,
for the prevention and treatment of mucosal and skin reactions caused by exposure to radioactive radiation.

Actovegin cream is also used for the prevention and treatment of bedsores.

Instructions for Actovegin cream

Reading these instructions for the use of Actovegin cream does not relieve the patient from studying "Instructions for the medical use of Actovegin cream" in the manufacturer's carton.

Actovegin cream should be used to accelerate the healing of wounds, including wounds with discharge (weeping ulcers).

Remedy applied at the second stage three-stage therapy with Actovegin after applying the gel. The cream is applied in a thin layer 2-3 times a day.

To prevent bedsores, Actovegin cream should be rubbed into the skin in high-risk areas.

When preventing the occurrence of radiation damage, the agent should be applied in a thin layer immediately after radiation therapy, in the intervals between sessions.

The frequency of use of Actovegin cream may vary depending on the clinical picture and the severity of the disease, determined by the doctor.

After the first opening of the package, the drug should be used within four weeks.

Actovegin ointment is applied topically under the following circumstances and pathologies:

with wounds and inflammation of the skin and mucous membranes, burns, skin cuts, scratches, abrasions,
in order to promote tissue regeneration after burns,
with ulcers of varicose origin, weeping ulcers,
for the prevention and treatment of mucosal and skin reactions caused by exposure to radioactive radiation,
during pre-treatment of wound surfaces before transplantation,

Also, the ointment is used for the prevention and treatment of bedsores.

The instruction on Actovegin ointment

Reading these instructions for use of Actovegin ointment does not exempt the patient from studying "Instructions for the medical use of Actovegin ointment" in the manufacturer's carton.

Ointment Actovegin should be used for long-term three-stage treatment of wounds and ulcers to accelerate and / or chemotherapeutic agents (mainly sulfonamides), antiseptics). The rate of administration is ~2 ml/min.

Do not use an opaque solution or a solution containing foreign particles. After opening the vial (ampoule), the solution can not be stored.

With intramuscular injections of Actovegin, the drug is administered slowly, not more than 5 ml. Due to the risk of an anaphylactic reaction, a test injection (2 ml per minute) is recommended.

After 30-40 minutes after using the product, an increase in body temperature, the appearance of rashes is possible. In such a situation, it is necessary to stop the course of treatment.

Actovegin solution for infusions

Actovegin 10% or 20% infusion (with or without glucose) solution is intended for intravenous or intra-arterial infusions. Actovegin infusion solution has a slightly yellowish tint. The color intensity may vary depending on the characteristics of the starting materials used, but does not adversely affect the activity of the drug or its tolerability.

The solution for infusion is used parenterally under the following circumstances:

with violations of the peripheral (venous and arterial) circulation, their consequences in the form of leg ulcers, arterial angiopathy,
in violation of cerebral metabolism and blood circulation (traumatic brain injury, ischemic stroke, cerebral insufficiency syndrome),
with complications arising from wound healing (pressure sores, poorly healing wounds),
with burns, ulceration of the skin,
in skin transplantation,
as a means of prevention and treatment of radiation damage to the skin, mucosa, and nervous tissue.

Instructions for the solution for infusion Actovegin

Reading these instructions for use of the solution for infusion Actovegin does not exempt the patient from studying "Instructions for the medical use of Actovegin infusion solution" in the manufacturer's carton.

Before using the solution, make sure that the vial is intact.

As a rule, the solution for infusion is used in a volume of 250 ml per day, intravenously or intra-arterially. The infusion rate should be ~2 ml/min. 10-20 infusions may be required to achieve maximum effect. It is allowed to increase the initial dose of 10% solution up to 500 ml.

When carrying out infusions, it is important to ensure that the solution does not enter extravascular tissues.

It is not allowed to add other drugs to the infusion solution of Actovegin.

Due to the risk of developing anaphylactic reactions, it is recommended to test for the presence of hypersensitivity to the drug before infusion.

In case of violation of blood supply and metabolism of the brain, the dosage is:

Initially, 250-500 ml (1000-2000 mg of the drug) intravenously per day for 2 weeks (with subsequent transition to the tablet form),
Further, 250 ml intravenously 3-4 times a week (for Actovegin infusions in dextrose solution) for 30 days or more.

In case of ischemic stroke, the administration of Actovegin infusion solution is carried out in 250-500 ml intravenously daily or several times a week for 14 days, followed by the transition to a tablet form.

In case of arterial angiopathy, it is necessary to inject 250 ml (1000 mg) intra-arterially and intravenously daily or several times a week for four weeks, followed by the transition to a tablet form (for infusions in sodium chloride solution),

With Ulcus cruris (varicose ulcer of the lower leg), other sluggish ulcers, burns, the solution for infusion should be administered 250 ml (1000 mg of the drug) intravenously daily or several times a week, depending on the healing rate, in addition to local therapy with Actovegin.

In case of diabetic polyneuropathy, 250–500 ml of a solution for infusion in sodium chloride solution should be administered intravenously daily for three weeks, followed by the transition to a tablet form (2–3 tablets three times a day for 4–5 months).

In the prevention and treatment of radiation damage to the skin and mucous membranes, 250 ml (1000 mg of the drug) is administered intravenously one day before it starts, daily during radiation therapy, for two weeks after it ends, followed by the transition to a tablet form. The rate of administration is ~2 ml per minute.

With repeated injections of Actovegin infusion solution, it is necessary to control the water and electrolyte balance of the blood plasma.

Do not use an opaque solution or a solution containing foreign particles.

The frequency, dose, method of administration of the solution may vary depending on the clinical picture and the severity of the disease, determined by the doctor.

Eye gel Actovegin

Eye gel Actovegin is applied topically for injuries of the cornea of the eye:

burns
inflammation of various origins,
in corneal transplantation in the preoperative and postoperative periods,
in patients with defects in the corneal epithelium due to wearing contact lenses.

Eye gel Actovegin is used for prophylactic selection of contact lenses in patients with impaired corneal trophism (atrophic and dystrophic processes), with age-related atrophic inflammation of the cornea.

Instructions for eye gel Actovegin

Reading these instructions for the use of Actovegin eye gel does not exempt the patient from studying "Instructions for the medical use of Actovegin ophthalmic gel" in the manufacturer's carton.

Eye gel should be applied to the diseased eye 1-3 times a day, 1-2 drops. When using the product, there may be an increased secretion of secretion, causing discomfort and pain.

The frequency and duration of application of the eye gel may vary depending on the cause and severity of the disease, determined by the attending physician.

After the first opening of the package, the drug should be used within four weeks.

Actovegin during pregnancy

Actovegin during pregnancy is prescribed to women who have already had a miscarriage (spontaneous abortion) to maintain the health of the fetus, further stable pregnancy.

An extract from the blood of young calves is the main element of Actovegin. The medicine promotes the accumulation and transport of glucose, oxygen in the body of a pregnant woman, and improves cell metabolism. Actovegin in pregnant women improves blood circulation, increases the energy reserves of cells and accelerates metabolic processes. The action of the drug begins after 15-30 minutes from the moment of administration. Before taking Actovegin, a pregnant woman should consult a doctor.

Actovegin is prescribed for pregnant women if the following complications occur:

If side effects occur, it is necessary to interrupt the course of treatment, consult a medical specialist.

At the moment, there have been no cases of negative effects of Actovegin on the fetus and the body of a pregnant woman in medicine.

When using the drug in pregnant women, it is necessary to take into account the potential risk to the fetus.

During breastfeeding, there are no contraindications against taking the drug.

Actovegin for children

Actovegin is prescribed for children (usually in tablets) for traumatic brain injuries, metabolic disorders, and circulatory disorders of the brain.

Actovegin is used in ophthalmology for the treatment of children with damage to the cornea of the eye, in the presence of burns, ulcers, abrasions, bedsores, and long-term healing wounds.

Actovegin is an extract from the blood of calves. Due to the physiological basis of the drug, the risk of side effects in children is minimal.

Actovegin is produced in the form of ointment, tablets, gel, cream and ampoules (injections). Depending on the type of disease, the duration of the course of the disease, the doctor prescribes the necessary type of medicine. Appointment of Actovegin to children is different from the use of this drug by adults.

The remedy in tablets is prescribed one piece once a day or half twice a day.

Actovegin injections for newborns are prescribed at a dose of 0.4-0.5 ml / kg once a day intramuscularly, for children aged one to three years - 0.4-0.5 ml / kg, three to six years - 0.25 -0.4 ml/kg once a day.

Before starting systematic injections of Actovegin in children, it is necessary to carry out a trial administration. Side effects of the drug are extremely rare, due to extreme sensitivity to individual components of the drug. Complications are manifested in the form of fever, skin hyperemia, urticaria. With such phenomena, it is necessary to stop taking the medicine, consult a doctor for symptomatic therapy.

Actovegin for atherosclerosis

The use of Actovegin in atherosclerosis avoids complications, surgical intervention. In atherosclerosis, the drug is initially used in the form of injections, then in the tablet form of the drug.

The formation of plaques in atherosclerosis occurs in the aorta, in medium and small arteries. During exercise, muscles require a significant amount of oxygen. Narrowed arteries impede blood supply, as a result, painful sensations arise. With a disease of the arteries of the lower extremities, a person constantly experiences pain, as a result, he needs constant stops, is not able to overcome significant distances on his own.

As a result of poor nutrition and oxygen supply, ischemic changes develop - ulcers and necrosis appear. With a long course of the disease and the absence of adequate treatment, a complete blockage of the vessel occurs, requiring an emergency surgical operation to prevent the development of gangrene. After completing the course of treatment with Actovegin for atherosclerosis, a person gets the opportunity to move more without feeling pain and spasms in the legs. In complex therapy, Actovegin improves microcirculation, has a positive effect on the transport and absorption of glucose, and stimulates the uptake of oxygen by cells.

The course use of Actovegin in patients with chronic obliterating diseases (diseases of the arteries of the lower extremities) involves intravenous injections of 800-1000 mg - from 14 to 28 days, then 200 mg tablets 1-2 tablets 3 times a day for 30 days, as a result, it decreases pain syndrome, including when walking.

Actovegin for the brain

Actovegin for the brain is used for cerebrovascular insufficiency - a chronic circulatory disorder of the brain against the background of arterial hypertension, heart disease, venous pathology, atherosclerosis.

With these complications, the brain is constantly in conditions of oxygen and energy deficiency, its normal functioning is disrupted. High blood pressure is a factor that provokes these disorders.

Actovegin is a neuroprotector that protects neurons from ischemia (insufficient blood supply to the organ), ensures the delivery of oxygen and glucose to neurons, satisfies the energy needs of the brain in conditions of "oxygen starvation". Due to the combination of antioxidant and antihypoxic properties, the action of the drug slows down pathological processes in the brain, provides regeneration (restoration) of damaged neurons and brain functions.

After completing a course of antihypertensive therapy together with Actovegin, neurological symptoms, memory, ability to concentrate improve, headaches, insomnia stop, working capacity returns, vitality, mood normalizes.

In chronic cerebrovascular insufficiency, tablets and ampoules of Actovegin 10 ml should be taken, initially injections for 10 days. After a course of injections, take 1-2 tablets of the drug 3 times a day, before meals, drinking plenty of water. It must be taken within 1-2 months.

Actovegin for varicose veins

An important mechanism for the development of varicose veins (venous insufficiency) is a violation of microcirculation and a violation of the functions of the endothelium of venous vessels. With varicose veins, Actovegin provides an antihypoxic effect, improves cell metabolism and microcirculation parameters, accelerates healing and epithelization in trophic ulcers. The complex action of Actovegin reduces symptoms (pain, swelling, "heavy legs syndrome"), prevents the progressive development of venous insufficiency.

Actovegin for bedsores

In the treatment of bedsores, all three forms of Actovegin for topical use (gel, cream and ointment) are used. It is allowed to use the drug in combination with other means (solutions of antiseptics).

In the stage of inflammation (first-fourth day), a twenty percent gel is applied to the wound, protecting it from infection. In the stage of granulation (formation of temporary tissue) on the first to fourteenth day, the wound surface of the bedsore is treated with a five percent cream. After the cessation of wet secretions and the beginning of epithelization (fourth to seventeenth days), Actovegin 5% ointment is applied. The combined use of all three forms of the drug contributes to faster and more active tissue regeneration.

Actovegin in diabetes mellitus

Actovegin in diabetes mellitus does not replace and does not compete with hypoglycemic therapy, it complements it. Actovegin saturates cells with glucose, without the risk of causing a sharp decrease in blood sugar. In effective therapeutic dosages, Actovegin does not cause the risk of hypoglycemia.

Blood glucose (blood sugar, glycemia) is the most important controlled variable in humans (homeostasis). The level of blood glucose is controlled by several physiological processes: it rises after a meal, it decreases due to catabolism, stress, physical exertion. In diabetes, blood glucose levels remain constantly high.

Against the background of hyperglycemia in patients with diabetes mellitus, sugar in the urine (glucosuria) is detected.

Sugar in the urine (glucose in the urine, glucosuria, glycosuria) is a laboratory term meaning the presence of sugar in the urine in excess of physiologically justified values. The kidneys are able to return to the bloodstream the entire volume of glucose that has passed through the renal glomerulus. Normally, in a healthy person, glucose in the urine is contained in small volumes (0.06 - 0.083 mmol / l), insufficient for determination in the laboratory.

The body, having lost the main source of energy, compensating for the deficiency, begins to secrete large amounts of hormones that mobilize fats, and primarily adrenaline and adrenocorticotropic hormone (ACTH). Under the influence of these hormones, endogenous fats (fats synthesized in the liver from carbohydrates) are intensively decomposed, and exogenous fats (fats from food) are not sufficiently utilized, which is accompanied by the synthesis of ketone bodies (acetone) in the liver, followed by excretion from the body with urine.

Acetone in the urine is a laboratory term meaning the detection of acetone in the urine in excess of physiologically justified values. Normally, in a healthy person, acetone is not detected in the urine, since it is utilized by the body, excreted with exhaled air, and in extremely small concentrations it can be excreted in the urine.

A systematic increase in sugar (glucose) with prolonged diabetes mellitus leads to disturbances in the functioning of the central nervous system. The nerves receive nutrition from the blood vessels, in diabetes mellitus, this process is disrupted due to oxygen starvation, the first symptoms of peripheral nerve damage appear - polyneuropathy. Damage to the nerves in diabetes mellitus leads to severe pain, impaired sensitivity, muscle cramps.

Diabetic polyneuropathy is one of the most common complications of diabetes mellitus, which significantly worsens the patient's quality of life, leading to the development of diabetic foot syndrome. The use of Actovegin in patients with diabetes mellitus improves the energy metabolism of tissues, increases the resistance of cells to ischemia and hypoxia, improves the transport and absorption of glucose, positively affecting the development of neurological symptoms.

Numbness of the legs in the evening is the first alarming symptom of the future occurrence of diabetic foot syndrome (ulcer-necrotic lesions of the skin, soft tissues, in severe cases, the bone tissue of the foot). With a decrease in sensitivity and insufficient blood supply, the healing process of microtraumas and calluses slows down, as a result, gangrene develops. Taking Actovegin in diabetes mellitus in combination with hypoglycemic therapy and diet compensates for the disease and prevents its complications. Under the action of Actovegin in diabetes mellitus, pain, paresthesia (goosebumps, numbness), cracks, ulcers disappear. The use of Actovegin (local and systemic forms) restores blood circulation in the ischemic zone, accelerates tissue regeneration in patients with ulcerative defects, improves microcirculation processes, endothelial function.

Wound healing in gangrene is achieved when blood glucose levels return to normal. The stimulating effect of the drug on wound healing is due to improved glucose utilization, regardless of the genesis (origin) of the wound, and even in the presence of resistance (resistance) to insulin.

Actovegin's analogs

The analogue (synonym) of Actovegin in terms of the active substance is the drug Solcoseryl, manufactured by the pharmaceutical company Solco, Switzerland. Actovegin differs from its counterpart in an extended shelf life.

Price Actovegin

The price of Actovegin tablets, gels, ointments, creams, ampoules and solutions does not include delivery costs if the drug is purchased through an online pharmacy. Prices can vary significantly depending on the place of purchase, dosage and form of release.

The cost of Actovegin:

Russia (Moscow, St. Petersburg) from 109 to 2150 Russian rubles,
Ukraine (Kyiv, Kharkov) from 36 to 710 Ukrainian hryvnias,
Kazakhstan (Almaty, Temirtau) from 513 to 10127 Kazakhstani tenge,
Belarus (Minsk, Gomel) from 28667 to 565450 Belarusian rubles,
Moldova (Chisinau) from 31 to 602 MDL,
Kyrgyzstan (Bishkek, Osh) from 119 to 2344 Kyrgyz soms,
Uzbekistan (Tashkent, Samarkand) from 4227 to 83377 Uzbek soums,
Azerbaijan (Baku, Ganja) from 1.6 to 32.0 Azerbaijani manats,
Armenia (Yerevan, Gyumri) from 749 to 14771 Armenian drams,
Georgia (Tbilisi, Batumi) from 3.7 to 73.1 Georgian lari,
Tajikistan (Dushanbe, Khujand) from 10.3 to 202.5 Tajik somoni,
Turkmenistan (Ashgabat, Turkmenabat) from 5.3 to 103.8 new Turkmen manats.

Buy Actovegin

You can buy Actovegin in the form of tablets, gel, ointment, cream, in ampoules for injections, infusion solution at a pharmacy using the drug reservation service, including. Before you buy Actovegin, you should clarify the expiration dates. You can order Actovegin at any available online pharmacy, the sale is carried out with home delivery by courier, upon presentation of a doctor's prescription.

Producer Actovegin

The manufacturer of Actovegin is the pharmaceutical company Nycomed (Switzerland), which is part of Takeda Pharmaceutical (Japan). In Russia, Actovegin is produced at the Sotex Pharmaceutical Company, owned by Protek.

Takeda Pharmaceutical Company Limited (武,田,«220,Ø97,ð37,業,株,ó35,Ê50,社,) is the largest Asian pharmaceutical company, one of the 15 largest in the world. Takeda's areas of interest include: metabolic, respiratory, cardiovascular diseases, gastroenterology, immunology, neurology, oncology. Nycomed was acquired by Takeda in 2011 for 9.6 billion euros. Takeda's largest US partner is Eli Lilly.

Eli Lilly is an American pharmaceutical company that produces drugs used in oncology, psychiatry, neurology, cardiology, and urology. Eli Lilly became the first company to mass-produce drugs used in the treatment of diabetes in the twenties of the 20th century (in particular, insulins under the Iletin trademark).

Storage Actovegin

Actovegin should be stored in a dry place, protected from light, out of the reach of children, at a temperature of +5 to +25 °C. It is not guaranteed that the medicinal properties of the drug will be preserved in case of violation of storage conditions, at a temperature regime that differs from that recommended by the manufacturer. Freezing of the drug is not allowed.

The shelf life of Actovegin is:

Tablets (drops) - 36 months from the date of release of the drug,
Gel - 36 months from the date of release of the drug,

Packing photo Actovegin cream 5% 20 grams.

Packing photo Actovegin ampoules 5 ml.

Actovegin instructions for use, indications and contraindications. In this article, you will read the instructions for use of the drug Actovegin (ACTOVEGIN®) - reviews, analogs and forms of release (tablets, injections in ampoules for injection, ointment, gel and cream) drugs for the treatment of metabolic disorders of the brain in adults, children ( newborns) and during pregnancy. ACTOVEGIN (ACTOVEGIN®) is an antihypoxant, is a hemoderivative, which is obtained by dialysis and ultrafiltration (compounds with a molecular weight of less than 5000 daltons penetrate).

It has a positive effect on the transport and utilization of glucose, stimulates oxygen consumption (which leads to stabilization of the plasma membranes of cells during ischemia and a decrease in the formation of lactates), thus providing an antihypoxic effect. Actovegin increases the concentrations of ATP, ADP, phosphocreatine, as well as amino acids (glutamate, aspartate) and GABA.

Actovegin instructions for use

Actovegin is a drug that stimulates the regeneration of cells and tissues damaged due to hypoxia and metabolic disorders. Active ingredient: calf blood hemoderivat. The drug is obtained by dialysis of the blood of calves, followed by ultrafiltration.

The drug consists entirely of physiological components and includes the most important amino acids, trace elements, peptides, a moderate amount of oligosaccharides. From this medical article, you can familiarize yourself with the drug Actovegin, the instructions for use will explain in which cases you can take the medicine, what it helps with. The effect of Actovegin on oxygen uptake and utilization, as well as insulin-like activity with stimulation of glucose transport and oxidation, are significant in the treatment of diabetic polyneuropathy.

Actovegin (Aktovegin): instructions for use. In patients with diabetes mellitus and diabetic polyneuropathy, Actovegin instructions for use significantly reduces the symptoms of polyneuropathy (stabbing pain, burning sensation, paresthesia, numbness of the lower extremities). Objectively, sensitivity disorders are reduced, the mental well-being of patients improves. The effect of Actovegin begins to appear no later than 30 minutes (10-30 minutes) after parenteral administration and reaches a maximum, on average, after 3 hours (2-6 hours).

Available in the form of a solution for injection, gels and ointments. The solution for injection is yellowish, practically free of particles. Excipients - water, sodium chloride. Also produced in tablet form, it is used as a prophylactic agent for correcting cerebral blood supply and maintaining mental activity.

Clinical and pharmacological group

A drug that activates the metabolism in tissues, improves trophism and stimulates the regeneration process. It has a pronounced antihypoxic effect, which manifests itself already half an hour after taking the drug, and reaches a maximum after 1-2 hours after using the drug. It is effective for reducing the symptoms of polyneuropathy in diabetics: it reduces pain, burning, impaired sensitivity, improves the physical and mental well-being of patients.

It is prescribed for patients with diabetes mellitus of both types to combat diabetic polyneuropathy. It has an insulin-like effect, due to which it reduces the level of glucose in the blood, delivering it to the cells of the body. It saturates the nerve cells with the necessary substances without causing a sharp drop in blood sugar levels. Patients receiving a course of Actovegin note a decrease in pain and restoration of the sensitivity of the lower extremities. Reduces the risk of diabetic foot and gangrene.

Composition (solution, injections)

Solution for infusion in solution of NaCl or dextrose:

Main substance: blood components (Hemoderivate deproteinized from the blood of calves 25 or 50 ml.);
Excipients: sodium chloride, water for injection + dextrose (for a solution with dextrose);
Physico-chemical properties: clear solution, colorless or slightly yellow;
Packing: 250 ml of solution in a glass bottle with a stopper and an aluminum cap. The bottle is placed in a cardboard box, which is protected by a transparent holographic sticker with opening control.

Injection:

Main substance: actovegin concentrate (calculated as Hemoderivative deproteinized from the blood of calves) 80 or 200 or 400 mg;
Excipients: sodium chloride, water for injection;
Physical and chemical properties: yellowish solution, transparent, practically devoid of particles;
Packaging: actovegin is produced in ampoules of 2, 5 and 10 ml with a break line. 5 ampoules in a package (contour, plastic) - 1 or 5 packs in a cardboard pack. Each pack is protected by a transparent sticker with a hologram and a tamper evident seal.

At the time of the course, it is necessary to abandon the use of alcoholic beverages, since ethanol will neutralize the entire therapeutic effect of Actovengin, and will accelerate the development of degenerative changes in the tissues of blood vessels and nerve endings. If you have vascular disease, you should stop smoking, as nicotine constricts blood vessels, disrupting the already difficult blood flow.

Composition (tablets)

Main substance: blood components: Hemoderivate deproteinized from the blood of calves 200 mg. (Actovegin instructions for use);
Excipients: Magnesium stearate, povidone, talc, cellulose. Shell: mountain glycol wax, acacia gum, hypromellose phthalate, diethyl phthalate, yellow quinoline dye, macrogol, aluminum varnish, povidone K30, talc, sucrose, titanium dioxide;
Physical and chemical properties: round, shiny greenish-yellow coated tablets;
Packing: 50 tab. in dark glass bottles, in a cardboard box.

Composition (gel 20%)

Main substance: hemoderivate deproteinized from the blood of calves 20 ml/100 gr.;
Excipients: carmellose sodium, calcium lactate, propylene glycol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, purified water;
Physical and chemical properties: homogeneous gel, yellowish or colorless;

Composition (cream 5%)

Physical and chemical properties: homogeneous white cream;
Packing: 20, 30, 50, 100 gr in aluminum tubes, in cardboard packs.

Composition (ointment 5%)

Main substance: hemoderivate deproteinized from the blood of calves 5 ml/100 gr.;
Excipients: macrogol 400 and 4000, cetyl alcohol, benzalkonium chloride, glyceryl monostearate, purified water;
Physical and chemical properties: homogeneous consistency ointment, white;
Packing: 20, 30, 50, 100 gr in aluminum tubes, in cardboard packs.

Price

Solution for infusion in p-re NaCl or dextrose. Price: 700-800 rubles;
Injection. Price: 2 ml 10 pcs.: 610-690 rubles; 2 ml 25 pcs.: 1300-1500 rubles; 5 ml 5 pcs.: 500-600 rubles; 10 ml 5 pcs.: 1000-1300 rubles;
Tablets. Price: 50 pcs.: 1400-1700 rubles;
Gel 20%. Price: 20 gr.: 170-200 rubles;
Cream 5%. Price: 20 gr.: 125-150 rubles;
Ointment 5%. Price: 20 gr.: 115-140 rub.

Indications for use

Metabolic and vascular disorders of the brain (including ischemic stroke, traumatic brain injury);
Peripheral (arterial and venous) vascular disorders and their consequences (arterial angiopathy, trophic ulcers);
Diabetic polyneuropathy;
Wound healing (ulcers of various etiologies, burns, trophic disorders (pressure sores), impaired wound healing processes);
Prevention and treatment of radiation damage to the skin and mucous membranes during radiation therapy.

Contraindications

Hypersensitivity to the drug Actovegin;
Decompensated heart failure;
Pulmonary edema;
Oliguria;
Anuria;
Hypersensitivity to similar drugs.

With caution: hyperchloremia, hypernatremia.

Side effects

skin hyperemia;
swelling;
Skin rash;
Anaphylactic shock;
medicinal fever;
Hyperthermia;
Hives.

Dosage

In / a, in / in (including in the form of infusion) and / m. Due to the potential for anaphylactic reactions, it is recommended that a test be performed prior to infusion. Actovegin instructions for use will help you.

Metabolic and vascular disorders of the brain: from 5 ml to 25 ml (200-1000 mg) per day i / v daily for 2 weeks, followed by the transition to Actovegin in the form of tablets;
Ischemic stroke: 20-50 ml (800-2000 mg) in 200-300 ml of 0.9% sodium chloride solution or 5% dextrose solution, intravenously daily for 1 week, then 10-20 ml (400-800 mg) in / in drip - 2 weeks, followed by the transition to Actovegin in the form of tablets;
Wound healing: 10 ml (400 mg) in / in or 5 ml / m daily or 3-4 times a week, depending on the healing process (in addition to local treatment with Actovegin in topical dosage forms);
Radiation cystitis: daily 10 ml (400 mg) transurethral in combination with antibiotic therapy. The rate of administration is about 2 ml/min. The duration of the course of treatment is determined individually in accordance with the symptoms and severity of the disease;
Peripheral (arterial and venous) vascular disorders and their consequences: 20-30 ml (800-1000 mg) of the drug in 200 ml of 0.9% sodium chloride solution or 5% dextrose solution, intravenously or intravenously daily; the duration of treatment is about 4 weeks;
Prevention and treatment of radiation damage to the skin and mucous membranes during radiation therapy: the average dose is 5 ml (200 mg) IV daily during breaks in radiation exposure;
Diabetic polyneuropathy: 50 ml (2000 mg) per day intravenously for 3 weeks, followed by the transition to Actovegin in the form of tablets - 2-3 tab. 3 times / day for at least 4-5 months.

The duration of the course of treatment is determined individually, depending on the symptoms and severity of the disease.

Release form

Film-coated tablets 200 mg;
Solution for injections (injections in ampoules) 40 mg/ml;
Gel for external use 20%;
Ointment for external use 5%;
Cream for external use 5%.

Pregnancy and lactation

The use of the drug in pregnant women did not cause negative effects on the mother or fetus. Actovegin instructions for use are always at hand. However, when used in pregnant women, the potential risk to the fetus must be considered.

Terms and conditions of storage

The drug should be stored out of the reach of children, in a place protected from light, at a temperature not exceeding 25 ° C. Shelf life - 5 years.

With caution, the drug is prescribed in situations where the risk of abortion is high: at the risk of placental abruption or diagnosed diabetes in the mother. In these cases, the drug is administered intravenously or intramuscularly, under the strict supervision of the attending physician.

Children with neurological lesions who were born as a result of a complicated pregnancy are prescribed Actovegin at the rate of 0.4 ml per kg of weight. Before use, a test for susceptibility to the components of the drug is carried out, the decision to prescribe and stop therapy is made by the attending physician. It is strictly forbidden to engage in self-diagnosis!

After opening the ampoule, the solution can not be stored.

Actovegin is used in violation of the patency of veins and arteries, to compensate for the lack of blood supply. The drug helps to deliver glucose and oxygen to cells, and also has a beneficial effect on the walls of blood vessels. It prevents the deposition of blood clots in both veins and arteries, restores blood flow in small vessels, tones the smooth muscles of veins and capillaries.

Actovegin instructions for use is used to treat thrombophlebitis and varicose veins, relieves swelling, prevents stretching of the walls of the veins and reduces thrombosis. Patients note a decrease in burning sensation and heaviness in the legs, the disappearance of bruising and a decrease in swelling.

special instructions

In the case of the / m method of administration, slowly inject no more than 5 ml.

Due to the possibility of an anaphylactic reaction, a trial injection (2 ml IM) is recommended.

The solution for injection has a slightly yellowish tint. The color intensity may vary from one batch to another depending on the characteristics of the starting materials used, but this does not adversely affect the activity of the drug or its tolerability.

Do not use a solution that is opaque or contains particles. Well read Actovegin instructions for use.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Analogues

The only drug that can rightfully be called an analogue of Actovegin is Solcoseryl. This analogue is produced in the form of ointments, creams and solutions for injections. The price of the drug is from 200 rubles. Some manufacturers set a high price for Solcoseryl.

In addition, there are drugs that have a similar pharmacological effect:

tablet forms. Curantyl and Dipyridamole improve blood circulation processes and can act as an analogue in the treatment of peripheral vascular diseases, the price of tablets is up to 700 rubles. Vero-Trimetazidine tablets are effective in the treatment of cerebral ischemia, the price is only 50-90 rubles;
Means for external use. Algofin - wound healing ointment at a price of 60 rubles per tube;
Injectable drugs. Cerebrolysin refers to nootropic drugs and is used as an analogue of Actovegin for pathologies of the central nervous system (price 900-1100r). Cortexin improves brain metabolism, costs from 700 rubles.

Actovegin instructions for use are often prescribed together with Mexidol to correct metabolic processes in the body. Comprehensive treatment allows you to achieve good results, but you should not administer both drugs in the same syringe, since mixing the components can affect the structure of the drugs and prevent their absorption.

When mixing drugs, the risk of developing an allergic reaction to the components of Actovegin increases. To expand the vessels, it is permissible to combine Actovegin with Cavinton and Trental. For the correction of neuropathy, a combination with Milgama or B vitamins is recommended. In the rehabilitation of stroke patients, a combination of Actovegin and Ceraxon is used.

In the treatment of fatty liver disease, a combination of Actovegin and Mildronate is often prescribed. For the treatment of chronic brain diseases, Actovegin is combined with Cerebrolysin or Cytoflavin. The combination of funds is selected by the doctor on the basis of the diagnosis, based on the individual characteristics of the patient's body.

The cheapest analogues are Memoria, Memorin, Omaron, Asafen, Nootropil - their price is lower than Actovegin. However, their pharmacological action is aimed only at improving memory. It should be emphasized that the composition of Actovegin analogues differs from the original drug. There are a number of restrictions on their use, and side effects occur more often.

Actovegin activates cellular metabolism (metabolism) by increasing the transport and accumulation of glucose and oxygen, enhancing their intracellular utilization. These processes lead to an acceleration of ATP (adenosine triphosphoric acid) metabolism and an increase in cell energy resources.

Under conditions that limit the normal functions of energy metabolism (hypoxia / insufficient supply of oxygen to the tissue or impaired absorption /, lack of substrate) and with increased energy consumption (healing, regeneration / tissue repair /), Actovegin stimulates the energy processes of functional metabolism (the process of metabolism in body) and anabolism (the process of assimilation of substances by the body). The secondary effect is increased blood supply.

They produce the following types:

Solution for injection 2 ml, 5.0 No. 5, 10 ml No. 10. Actovegin injections fit in colorless glass ampoules that have a break point. Packed in a blister pack of 5 pieces.
The solution for infusion (Actovegin intravenously) is placed in 250 ml bottles, which are corked and placed in a cardboard box.
Actovegin tablets have a round biconvex shape, covered with a yellow-green shell. Packed in dark glass bottles of 50 pieces.
The cream is packaged in tubes of 20 g.
Gel 20% is packaged in tubes of 5 g.
Actovegin eye gel 20% is packaged in tubes of 5 g.
Ointment 5% is packaged in tubes of 20 g.

The composition of the drug Actovegin, which helps with insufficient blood flow, includes deproteinized hemoderivat from calf blood as an active substance. The injection also contains sodium chloride and water as additional substances.

According to the pharmacological properties, Actovegin belongs to the group of tissue regeneration stimulants. It improves the flow of oxygen and glucose into cells, accelerates metabolism and healing processes, and increases the energy resources of the body. It is used in neurology, ophthalmology, transplantology, dermatology and therapy. In the sports world, it is known as one of the doping drugs.

Active ingredient: deproteinized standardized hemodialysate (otherwise hemoderivat) from the blood of dairy calves.

The use of Actovegin has the following effect:

The drug improves the absorption of oxygen by brain cells.
It promotes the formation of acetylcholine and ATP in the brain cells.
The drug helps glucose to better penetrate into neurons, which has a positive effect on the nutrition of brain cells.
The tool acts as a strong antioxidant.
The medicine also has a beneficial effect on liver cells and myocardial tissues.

Indications for use

Why is Actovegin prescribed? Indications differ depending on the form of release of the drug.

Indications for the appointment of Actovegin tablets:

violations of blood circulation in the brain after diseases, injuries at the stage of recovery;
violations of blood circulation in the peripheral arteries in the initial stages or after injections; obliterating atherosclerosis, obliterating endarteritis (inflammation of the walls of the arteries) of the extremities are subject to treatment;
disorders of blood circulation in the veins - varicose veins, trophic ulcers of the lower extremities, thrombophlebitis at the recovery stage;
diabetes mellitus, complicated by damage to blood vessels and nerves (diabetic angioneuropathy), in the initial stages or at the stage of recovery.

Indications for Actovegin injections and droppers:

acute period of illness, injury;
violations of blood circulation in the brain with cervical osteochondrosis;
decreased intelligence against the background of age-related or post-traumatic disorders;
severe course of obliterating endarteritis, obliterating atherosclerosis, Raynaud's disease;
severe venous insufficiency, recurrent thrombophlebitis, leg ulcers;
extensive bedsores in bedridden patients, long-term non-healing wounds;
extensive burn lesions;
diabetic foot;
radiation injury;
skin transplant.

Actovegin is prescribed externally for:

fresh wounds, small burns, frostbite;
inflammatory skin diseases at the healing stage;
extensive burns at the stage of recovery;
bedsores, trophic ulcerative processes;
radiation burns;
skin graft.

20% eye gel for:

corneal burns;
corneal erosions;
acute and chronic keratitis;
processing of the cornea before its transplantation;
radiation burns of the cornea;
corneal microtrauma in contact lens wearers.

Instructions for use Actovegin, dosage

Intra-arterially, intravenously (including in the form of infusion) and intramuscularly. In connection with the potential for the development of anaphylactic reactions, it is recommended to test for the presence of hypersensitivity to the drug before infusion.

Depending on the severity of the clinical picture, the initial dose is 10-20 ml / day intravenously or intra-arterially; then 5 ml intravenously or 5 ml intramuscularly.

When administered in the form of an infusion, 10-20 ml of ACTOVEGIN© is added to 200-300 ml of the stock solution (0.9% sodium chloride solution or 5% dextrose solution). Injection rate: about 2 ml/min.

Metabolic and vascular disorders of the brain: at the beginning of treatment, 10 ml intravenously daily for two weeks, then 5-10 ml intravenously 3-4 times a week for at least 2 weeks.

Ischemic stroke: 20-50 ml in 200-300 ml of stock solution intravenously drip daily for 1 week, then 10-20 ml intravenously drip - 2 weeks.

Peripheral (arterial and venous) vascular disorders and their consequences: 20-30 ml of the drug in 200 ml of the stock solution intra-arterially or intravenously daily; the duration of treatment is about 4 weeks.

Wound healing: 10 ml intravenously or 5 ml intramuscularly daily or 3-4 times a week, depending on the healing process (in addition to local treatment of Actovegin in topical dosage forms).

Prevention and treatment of radiation damage to the skin and mucous membranes during radiation therapy: the average dose is 5 ml intravenously daily during breaks in radiation exposure.

Radiation cystitis: daily 10 ml transurethral in combination with antibiotic therapy.

Tablets

It is necessary to take the tablets before meals, they do not need to be chewed, they should be washed down with a small amount of water. In most cases, 1-2 tablets are prescribed three times a day. Therapy usually lasts 4 to 6 weeks.

For people suffering from diabetic polyneuropathy, the drug is initially administered intravenously at 2 g per day for three weeks, after which tablets are prescribed - 2-3 pcs. per day for 4-5 months.

Gel and ointment Actovegin

The gel is applied topically to cleanse wounds and ulcers, as well as their subsequent treatment. If there is a burn or radiation injury on the skin, the product should be applied in a thin layer. In the presence of an ulcer, the gel is applied in a thick layer and covered with a compress on top, which is saturated with Actovegin ointment.

The bandage should be changed once a day, but if the ulcer gets very wet, then this should be done more often. For patients with radiation injuries, the gel is applied in the form of applications. For the purpose of treatment and prevention of bedsores, dressings should be changed 3-4 times a day.

The ointment is applied in a thin layer to the skin. It is used for long-term treatment of wounds and ulcers in order to accelerate their epithelization (healing) after gel or cream therapy. For the prevention of bedsores, the ointment must be applied to the appropriate areas of the skin. To prevent radiation damage to the skin, the ointment should be applied after irradiation or in between sessions.

eye gel

Squeeze 1 drop of gel directly from the tube into the affected eye. Apply 2-3 times a day. After opening the package, the eye gel can be used for no more than 4 weeks.

Side effects

Most often, the drug is well tolerated. However, sometimes a side process may occur - allergies, anaphylactic shock or other reactions:

hypersensitivity occurs;
increase in temperature;
trembling, angioedema;
skin plethora;
rash, irritation;
increased sweat separation;
swelling of the skin or mucous membranes;
transformation in the injection zone;
dyspeptic phenomena;
pain in the epigastric area;
vomiting, diarrhea;
feeling of pain in the region of the heart, rapid pulse;
shortness of breath, pale skin;
jumps in blood pressure, frequent breathing, a feeling of squeezing in the chest;
soreness in the throat;
pain in the head, dizziness;
agitation, trembling;
soreness of muscles, joints;
discomfort in the lumbar region.

When the use of Actovegin leads to the listed side effects, its use should be terminated, if necessary, symptomatic therapy is prescribed.

Use during pregnancy and lactation

Use Actovegin during pregnancy and lactation only when the expected benefit to the mother outweighs the possible risk to the fetus or child. During the use of the drug in placental insufficiency, although rarely, fatal cases were observed, which could be a consequence of the underlying disease. The use during lactation was not accompanied by negative effects either for the mother or for the child.

Contraindications

Actovegin is not used in the following conditions:

individual intolerance to the drug or its components;
during pregnancy is prescribed with caution;
its use during lactation is undesirable;
heart diseases;
pulmonary edema;
with oliguria and anuria.

Analogues and price Actovegin, list of drugs

The only analogue of Actovegin is Solcoseryl. It is produced by the German pharmaceutical concern Valeant.

An analogue of an external agent is produced by the Belarusian pharmaceutical enterprise "Dialek". This is a drug in the gel form Diavitol. The main active ingredient of the drug is a deproteinized extract from embryos and calf blood.

Analogues by scope, list:

Divaza
Anantavati
Mexidol
Noben
Cinnarizine
Armadin Solution
Nootropil
Vinpotropil
Stugeron
Metapainting
Cardionate
Dmae (Dmae)
Tanakan

When choosing analogues, it is important to understand that the instructions for use of Actovegin, the price and reviews for drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Prices in Russian pharmacies: Actovegin, tablets 50 pcs. - 1612 rubles, solution for injection, 40 mg / ml ampoules 5 ml 5 pcs - 519 rubles.

Store in a place protected from light, at a temperature of 18–25 °C. Leave in pharmacies by prescription.

In this article, you can read the instructions for using the drug Actovegin. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Actovegin in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Actovegin in the presence of existing structural analogues. Use for the treatment of metabolic and vascular disorders of the brain, tissue trophism, burns and bedsores, diabetic polyneuropathy in adults, children (including newborns), as well as during pregnancy and lactation.

Actovegin- antihypoxant, is a gemoderivate, which is obtained by dialysis and ultrafiltration (compounds with a molecular weight of less than 5000 daltons penetrate).

Actovegin increases the concentrations of ATP, ADP, phosphocreatine, as well as amino acids (glutamate, aspartate) and GABA.

The effect of Actovegin on oxygen uptake and utilization, as well as insulin-like activity with stimulation of glucose transport and oxidation, are significant in the treatment of diabetic polyneuropathy.

In patients with diabetes mellitus and diabetic polyneuropathy, Actovegin significantly reduces the symptoms of polyneuropathy (stabbing pain, burning sensation, paresthesia, numbness of the lower extremities). Objectively, sensitivity disorders are reduced, the mental well-being of patients improves.

The effect of Actovegin begins to appear no later than 30 minutes (10-30 minutes) after parenteral administration and reaches a maximum, on average, after 3 hours (2-6 hours).

Compound

Deproteinized hemoderivat from calf blood (Actovegin concentrate or granulate) + excipients.

Pharmacokinetics

Using pharmacokinetic methods, it is impossible to study the pharmacokinetic characteristics (absorption, distribution, excretion) of the active components of Actovegin, since it consists only of physiological components that are usually present in the body.

To date, no decrease in the pharmacological efficacy of hemoderivatives has been found in patients with altered pharmacokinetics (including with hepatic or renal failure, metabolic changes associated with advanced age, due to the peculiarities of metabolism in newborns).

Indications

metabolic and vascular disorders of the brain (including ischemic stroke, traumatic brain injury);
peripheral (arterial and venous) vascular disorders and their consequences (arterial angiopathy, trophic ulcers);
diabetic polyneuropathy;
wound healing (ulcers of various etiologies, trophic disorders /bedsores/, burns, impaired wound healing processes);
prevention and treatment of radiation damage to the skin and mucous membranes during radiation therapy.

Release form

Film-coated tablets 200 mg.

Solution for injections (injections) 40 mg/ml in ampoules of 5 ml and 10 ml.

Ointment for external use 5% (not supplied to Russia).

Cream for external use 5% (not supplied to Russia).

Gel for external use 20% (not supplied to Russia).

Instructions for use and dosage

Tablets

Assign inside 1-2 tablets 3 times a day before meals. The tablet is not chewed, washed down with a small amount of water. The duration of treatment is 4-6 weeks.

Ampoules

The solution for injection is administered intra-arterially, intravenously (including as an infusion or dropper) and intramuscularly. The infusion rate is about 2 ml / min. In connection with the potential for the development of anaphylactic reactions, it is recommended to test for the presence of hypersensitivity to the drug before infusion.

The duration of the course of treatment is determined individually, depending on the symptoms and severity of the disease.

Metabolic and vascular disorders of the brain: from 5 to 25 ml (200 - 1000 mg per day) intravenously daily for two weeks, followed by the transition to a tablet form.

Ischemic stroke: 20-50 ml (800-2000 mg) in 200-300 ml of 0.9% sodium chloride solution or 5% dextrose solution intravenously daily for 1 week, then 10-20 ml (400-800 mg ) intravenously drip - 2 weeks, followed by the transition to a tablet form.

Peripheral (arterial and venous) vascular disorders and their consequences: 20-30 ml (800-1000 mg) of the drug in 200 ml of 0.9% sodium chloride solution or 5% dextrose solution intra-arterially or intravenously daily; the duration of treatment is 4 weeks.

Diabetic polyneuropathy: 50 ml (2000 mg) per day intravenously for 3 weeks, followed by the transition to a tablet form - 2-3 tablets 3 times a day for at least 4-5 months.

Wound healing: 10 ml (400 mg) intravenously or 5 ml intramuscularly daily or 3-4 times a week, depending on the healing process (in addition to local treatment with Actovegin in dosage forms for external use).

Prevention and treatment of radiation damage to the skin and mucous membranes during radiation therapy: the average dose is 5 ml (200 mg) intravenously daily during breaks in radiation exposure.

Radiation cystitis: 10 ml (400 mg) daily transurethral in combination with antibiotic therapy.

Side effect

skin rash;
skin hyperemia;
hyperthermia;
hives;
swelling;
medicinal fever;
anaphylactic shock.

Contraindications

decompensated heart failure;
pulmonary edema;
oliguria, anuria;
fluid retention in the body;
hypersensitivity to the components of the drug;
hypersensitivity to similar drugs.

Use during pregnancy and lactation

The use of the drug during pregnancy did not have a negative effect on the mother or fetus, however, if necessary, the use of the drug during pregnancy should take into account the potential risk to the fetus. So the use of Actovegin in these cases requires caution.

special instructions

In connection with the potential for the development of anaphylactic reactions, it is recommended to conduct a test (trial injection of 2 ml / m) before infusion.

In the case of an intramuscular route of administration, the drug should be administered slowly in an amount of not more than 5 ml.

Solutions of Actovegin have a slightly yellowish tint. The color intensity may vary from one batch to another, depending on the characteristics of the starting materials used, but this does not affect the effectiveness and tolerability of the drug.

Do not use an opaque solution or a solution containing particles.

With repeated injections, the water-electrolyte balance of the blood plasma should be monitored.

After opening the ampoule or vial, the solution cannot be stored.

drug interaction

Drug interaction of the drug Actovegin has not been established.

However, in order to avoid possible pharmaceutical incompatibility, it is not recommended to add other drugs to Actovegin infusion solution.

Analogues of the drug Actovegin

The drug Actovegin has no structural analogues for the active substance.

Analogues by pharmacological group (antihypoxants and antioxidants):

Actovegin granulate;
Actovegin concentrate;
Antisten;
Astrox;
Vixipin;
Vitanam;
Hypoxen;
Glation;
Deprenorm;
Dihydroquercetin;
Dimephosphone;
Cardioxipin;
Carditrim;
Carnitine;
Carnifit;
Kudevita;
Kudesan;
Kudesan for children;
Kudesan Forte;
Levocarnitine;
Limontar;
Meksidant;
Mexidol;
Mexidol solution for injections 5%;
Mexicor;
Mexipridol;
Mexiprim;
Mexifin;
Methylethylpyridinol;
Metostabil;
Sodium hydroxybutyrate;
Neurox;
Neurolipon;
Octolipen;
Olifen;
Predizin;
Preductal;
Rexod;
Rimecore;
Solcoseryl;
Thiogamma;
Thiotriazoline;
Trekrezan;
Triducard;
Trimectal;
Trimetazidine;
Phenosanoic acid;
Cerecard;
Cytochrome C;
Eltacin;
Emoxybel;
Emoxipin;
Enerlit;
Yantavit.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.