Furacilin: instructions for use, analogues and reviews, prices in Russian pharmacies. How to prepare a solution of furacilin from tablets Furacilin is used for treatment

Furacilin is an antibacterial and antiprotozoal agent for external and topical use..

pharmachologic effect

Active ingredient
Furacilina has an antimicrobial effect.

Unlike other chemotherapeutic agents, Furacilin has a different mechanism of action and forms highly reactive amino derivatives that cause conformational changes in macromolecular proteins, which leads to cell death.

Furacilin is active against most gram-positive and gram-negative bacteria, for example:

• Streptococcus spp.;
• Salmonella spp.;
• Staphylococcus spp.;
• Shigella (flexneri spp.., dysenteria spp., boydii spp., sonnei spp.);
• Clostridium perfringens;
• Escherichia coli..

Resistance to the active component of Furacilin develops slowly and, as a rule, does not reach a high degree. In addition, the tool helps to increase the activity of the reticuloendothelial system and enhance phagocytosis.

Release form Furacilin

The drug Furacilin is produced in the form:

• Alcoholic 0.067% solution for local and external use, in vials of 10 and 25 ml;
• Tablets for the preparation of a solution for topical use, 20 and 100 mg;
• Solution of 0.02% for local and external use, in vials of 200 and 400 ml;
• Pastes for external use, 1 and 2 kg each;
• Ointments 0.2% for local and external use, 25 g each.

Furacilin analogues are the following drugs:

• According to the active substance - Lifusol, Furaplast, Furatsilin-LekT;
• According to the mode of action - Kombutek-2.

Indications for use Furatsilina

According to the instructions, Furacilin is prescribed externally for the treatment of:

• pressure sores;
• Purulent wounds;
• Minor damage to the skin, including scratches, abrasions, cuts and cracks;
• Frostbite II-III degree;
• Burns II-III degree.

Locally Furacilin according to the instructions is used for:

• conjunctivitis;
• Gingivitis;
• Blepharitis;
• Empyema of the pleura and paranasal sinuses;
• osteomyelitis;
• Acute external and average otitis;
• urinary tract infections;
• stomatitis;
• Acute tonsillitis.

Contraindications

The use of Furacilin is contraindicated in the following cases:

• With bleeding;
• Against the background of existing allergic dermatoses;
• With hypersensitivity to the components of Furacilin.

How to use Furacilin

According to the indications, Furacilin can be used in various dosage forms.

In the treatment of blepharitis and conjunctivitis, Furacilin is used according to the instructions:

• Aqueous solution - in the form of instillation into the conjunctival sac;
• Ointment - to lubricate the edges of the eyelids.

For rinsing with furatsilin mouth
and throat, it is recommended to use a solution obtained from one tablet dissolved in 100 ml of water.

Furacilin in the form of an ointment is used to treat burns and frostbite of I-II degrees, as well as mucous membranes and superficial skin wounds. Duration of use - up to three days.

The use of Furacilin in the form of an alcohol solution (5-6 drops each) is effective in the treatment of otitis media. Before use, the solution should be warmed to body temperature. The remedy is recommended to be used daily until the symptoms of the disease disappear.

Outwardly, for irrigation of wounds and the application of wet dressings, both alcohol and aqueous solutions of Furacilin can be used.

Washing with Furacilin is effective for empyema of the paranasal sinuses, including sinusitis, for which an aqueous solution prepared or prepared from tablets is used.

In addition, flushing with Furacilin is effective:

• With osteomyelitis after surgery (followed by the imposition of a wet bandage);
• For washing the bladder and urethra (with exposure to an aqueous solution for 20 minutes);
• After removal of pus in pleural empyema (using an aqueous solution in an amount of 20-100 ml to wash the pleural cavity).

Side effects of furatsilina

When Furacilin is used according to indications, dermatitis and allergic reactions may develop in some cases.

Storage conditions

According to indications, Furacilin is dispensed from pharmacies without medical prescription. The shelf life of the drug is up to two years (subject to storage requirements).

Sincerely,

Chemical Name: 5-nitro-2-furaldehyde semicarbazone

General characteristics. The drug is a clear yellow solution

The composition of the medicinal product.

Release form: Solution for external use

Pharmacotherapeutic group: Antiseptics and disinfectants. Nitrofuran derivatives.

ATX code: D08AF01

pharmacological properties. Pharmacodynamics. An antimicrobial agent from the group of nitrofuran derivatives. It has a bacteriostatic effect on gram-positive and gram-negative bacteria (staphylococci, streptococci, E. coli, Proteus, Salmonella, Escherichia), as well as Trichomonas and Giardia.

Microorganisms resistant to antibiotics and sulfonamides are sensitive to furacilin. Resistance to furacilin develops slowly and does not reach a high degree.

Pharmacokinetics. With local and external use, absorption is negligible. When ingested, absorption is rapid and complete. Penetrates through histohematic barriers and is evenly distributed in fluids and tissues. The time required to reach maximum concentration is 6 hours. The main metabolic pathway is the reduction of the nitro group. It is excreted by the kidneys and partially through the intestines.

Indications for use

Purulent infected wounds, bedsores, ulcers;

Infected burns II and III degree;

Preparation of the granulating surface for skin grafts;

Osteomyelitis;

Pleural empyema;

Furuncle of the external auditory canal;

Empyema of the paranasal sinuses;

Conjunctivitis.

Dosage and administration

For purulent wounds, bedsores, ulcers, II and III degree burns, to prepare the granulating surface for skin grafting and for the secondary suture, irrigate the wound with an aqueous solution of furacilin and apply wet dressings.

In osteomyelitis, after surgery, the cavity is washed with an aqueous solution of furacilin and a wet bandage is applied.

With pleural empyema, pus is sucked off, the pleural cavity is washed, followed by the introduction of 20-100 ml of an aqueous solution of furacilin into the cavity.

In the treatment of boils of the external auditory canal and empyema of the paranasal sinuses, the damaged areas are washed 2-4-6 times a day (depending on the severity of the damage).

In the treatment of conjunctivitis - instillation of an aqueous solution into the conjunctival sac, 2-3 drops 3-4 times a day.

The duration of treatment is determined by the doctor, taking into account the characteristics of the disease, the tolerance of the drug and the effect achieved.

Side effect

When applied topically, furatsilin is usually well tolerated. In some cases, dermatitis is possible, requiring a temporary break or discontinuation of the drug. Bleeding.

In the event of adverse reactions, including those not listed in this leaflet, you should stop using the drug and consult a doctor.

Contraindications

Severe renal dysfunction;

Allergic dermatoses;

Hypersensitivity to nitrofuran derivatives.

Overdose

Precautionary measures

Due to the lack of sufficient data on the safety of use, the drug is not recommended for use in children and adolescents under the age of 18 years.

When using the drug, the so-called cross-sensitization is possible. To avoid sensitization, it is recommended to use the drug for no more than 5 days.

If during the use of the drug the symptoms of the disease persist or the condition worsens, it is necessary to stop using the drug and consult a doctor.

Use during pregnancy and lactation. When prescribing to pregnant women, women during lactation and children, it is recommended to take into account the possible balance of risk and benefit from the use of this drug.

Influence on the ability to drive vehicles and potentially dangerous mechanisms. There was no effect on the ability to drive vehicles and potentially dangerous mechanisms.

Interaction with other drugs

Incompatible with epinephrine (adrenaline), tetracaine, procaine (novocaine), resorcinol (resorcinol) and other reducing agents, as it decomposes to form pinkish or brownish colored products.

Incompatible with potassium permanganate, hydrogen peroxide and other oxidizing agents due to oxidation of the drug.

Latin name: Furacilin
ATX code: D08AF01
Active substance: Nitrofural
Manufacturer: Tatkhimfarmpreparaty, Russia
Pharmacy leave condition: Without recipe

Furacilin is one of the antiprotozoal drugs with antibacterial properties, can be applied topically and topically.

Indications for use Furatsilina

Not everyone knows exactly how Furacilin is used, what helps. An available antibacterial agent can be prescribed for both adults and children. Each of the forms of the drug Furacilin is very convenient to use. It is recommended to use drugs externally in such cases:

• Wound surfaces with suppuration
• bedsores
• Minor damage to the skin
• Frostbite and burns of varying severity.

Local use of the drug is indicated for:

• Acute tonsillitis
• stomatitis
• Blepharitis
• gingivitis
• Inflammatory process in the middle ear
• Osteomyelitis
• Infectious diseases of the urinary tract
• Conjunctivitis
• Empyema of the pleura and paranasal sinuses.

Composition of Furacilin

Furacilin tablets contain 20 mg of the main active ingredient, represented by nitrofural, as well as 0.8 mg of another substance, which is sodium chloride.

Furacilin effervescent (Avexima) includes 20 mg of the main active ingredient. Additionally present:

• Sodium carbonate and bicarbonate
• Wine acid
• macrogol
• Sodium chloride.

The basis of an aqueous solution of Furacilin is nitrofural and saline in a ratio of 1:5000.

The alcohol solution of Furacilin, in addition to nitrofural, contains 70% ethanol, the proportions of these components are 1:1500.

The ointment consists of 0.002 g of nitrofural, as well as white paraffin.

Medicinal properties of Furacilin

The active substance of this drug exhibits a pronounced antimicrobial effect.

Compared to other pharmaceutical drugs, it is characterized by a completely different principle of action. In contact with mucous membranes, the formation of highly reactive amino derivatives is observed, which lead to conformational changes within the proteins of pathogenic molecules. This results in the death of microbes.

Furacilin is active against gram-positive and gram-negative flora, including streptococci, salmonella, staphylococci, shigella.

The development of resistance to such a substance as nitrofural is slow, and generally does not reach maximum values. Along with this, the drug increases the activity of the reticuloendothelial system, and also enhances phagocytosis.

Release form

Price per tablet: from 60 to 110 rubles.

Tablets for the manufacture of a solution - Furacilin Avexima with a dosage of 20 mg are produced in packages. Each of them has 10 or 20 tab. (1 or 2 blisters) Furacelin Avexima, instructions.

Tablets intended for local use and oral administration with a dosage of 100 mg are available in packs of 12, 24 and 30 pcs.

The ointment, which is applied topically and externally, is packaged in jars, the volume of which is 25 g.

Furacilin solution 0.02% is produced in 100 ml glass bottles.

A solution of 0.067% is sold in bottles of 10 mg or 25 ml.

Furacilin tablets: instructions for use

The price of the ointment: from 35 to 82 rubles.

Not everyone knows how to use Furacilin, which helps. Along with this, information about whether it is possible to gargle with Furacilin is not at all known to everyone.

Of course, you can prepare a solution of Furacilin, as well as apply it to the throat (for rinsing) and treating damaged skin.

How to dilute Furacilin tablets

It is worth noting that Furacilin with angina is very effective, as it quickly eliminates the inflammatory process. Before you prepare a solution of Furacilin, you will need to grind one antibacterial tablet with a dosage of 20 mg. This powder must be poured with 100 ml of boiled water only. To increase the therapeutic effect of the ongoing treatment, add 2 teaspoons of a 3% hydrogen peroxide solution to the cooled solution. Rinsing with Furacilin for angina should be carried out at regular intervals of 4-6 p. throughout the day. The prepared solution of Furacilin for gargling can be used for a long time, it retains its antibacterial properties.

It must be remembered: Before diluting the antimicrobial tablet, you will first need to boil water, unboiled water is not used for this purpose.

Features of the use of Furacilin

Solution price: from 29 to 105 rubles.

In the treatment of acute bacterial dysentery, you should drink tablets four times a day, 1 tab. (best after meals) for 5-6 days. After a four-day break, you can start taking the medicine again.

A solution of Furacilin from tablets can be used to carry out the rinsing procedure for babies, it is recommended to carry it out under the strict supervision of an adult. Gargling with Furacilin for angina can be alternated with the procedure for irrigating the oral cavity with therapeutic aerosols (spray with anti-inflammatory action).

Furacilin for gargling can be used for a long time, you need to be treated until the observed symptoms disappear completely. Information on how to dilute Furacilin tablets, as well as how to make a solution from Furacilin Avexima correctly, should be provided by your doctor.

Furacilin solution for gargling can also be used for other purposes:

• With osteomyelitis in the postoperative period (it is necessary to apply a bandage)
• During the washing of the nasal sinuses, as well as the organs of the urinary system (an exposure lasting 20 minutes is carried out)
• After the procedure for removing purulent contents in case of pleural empyema.

Use of alcohol, aqueous solution

This dosage form is indicated for the treatment of various types of otitis media. The solution is instilled into the ear canal (5-6 drops) after preliminary warming up in the palms. Such procedures should be carried out every day until complete recovery.
It is also recommended for adults with children to wash the mucous membrane of the conjunctival sac with an aqueous antibacterial solution.
External use for irrigation of wound surfaces can be carried out with both an aqueous and alcoholic antibacterial solution of Furacilin.

Ointment Furacilin: instructions for use

The use of ointment is recommended for the treatment of burns, as well as frostbite of varying severity, as well as wound surfaces. Applications can be applied to both adults and children. Duration of application - up to 3 days.

Use during pregnancy and breastfeeding

The use of this antibacterial agent is allowed for this group of patients.

Contraindications

You should not use an antibacterial agent in the following cases:

• Tendency to bleed
• The presence of allergic dermatoses
• Excessive susceptibility to nitrofural.

Precautionary measures

It should be borne in mind that during the use of the drug, allergic reactions caused by sensitivity to the main component of the drug may develop.

Side effects

With prolonged use of the drug, inflammation of the skin, hyperemia can be observed. This is the main indication for the completion of ongoing therapy.

When taken orally, reactions from the gastrointestinal tract, allergies, dizziness can be diagnosed.

Overdose

There is an increase in the observed adverse symptoms.

Storage conditions and shelf life

It is recommended to store each of the dosage forms of Furacilin at a temperature not exceeding 25 C. The shelf life of antibacterial tablets for external use is 5 years, oral tablets - 4 years, antibacterial ointment with an alcohol-based solution - 2 years.

Analogues

Olainfarm, Latvia

Price from 116 to 367 rubles.

Furagin is a drug that has an antimicrobial effect. It should be used to eliminate the inflammatory process in the complex treatment of infectious diseases of the urinary system. The active substance of these tablets is furazidin.

Pros:

• Exhibits a wide spectrum of antimicrobial activity
• High efficiency
• Used in pediatrics.

Minuses:

• Contraindicated during pregnancy, lactation
• May cause angioedema
• Released by prescription.

in planimetric non-cell packing 10 pcs.; in a pack of cardboard 1 or 2 packs.

Description of the dosage form

Tablets are yellow or greenish-yellow in color with an uneven surface color.

pharmachologic effect

Pharmacodynamics

The antimicrobial agent, penetrating inside the microbial cell, lengthens the resting phase (interphase) and, thereby, inhibits division. Active against Gram-positive and Gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Shigella dysenteriae spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Escherichia coli, Clostridium perfringens, Salmonella spp. and etc.).

Indications of the drug Furacilin

purulent wounds;

bedsores;

burns II-III degree;

to prepare the granulating surface for skin grafts;

blepharitis;

conjunctivitis;

furuncles of the external auditory canal;

osteomyelitis;

empyema of the paranasal sinuses and pleura (washing of the cavities);

acute external and otitis media;

stomatitis;

gingivitis;

minor skin damage (including abrasions, scratches, cracks, cuts).

Contraindications

hypersensitivity;

chronic allergic dermatoses;

bleeding.

Side effects

Dermatitis is possible, requiring a temporary break or complete cessation of the use of the drug.

Dosage and administration

Outwardly, in the form of water 0.02% (1:5000) or alcohol 0.066% (1:1500) solutions - irrigate wounds and apply wet bandages. intracavitary- wash the maxillary and pleural cavity, oral cavity.

To prepare an aqueous solution, 1 part of nitrofural is dissolved in 5000 parts of isotonic sodium chloride solution or distilled water. The solution is sterilized at 100 °C for 30 minutes. An alcohol solution is prepared in 70% ethanol.

Storage conditions of the drug Furacilin

Keep out of the reach of children.

Shelf life of the drug Furacilin

Do not use after the expiry date stated on the packaging.

Instructions for medical use

R N002885/01 dated 2018-04-19
Furacilin - instructions for medical use - RU No. LSR-009026/10 dated 2015-03-04
Furacilin - instructions for medical use - RU No. LSR-001149/10 dated 2018-11-06
Furacilin - instructions for medical use - RU No. LSR-009026/10 dated 2017-04-18
Furacilin - instructions for medical use - RU No. LP-003268 dated 2016-05-12
Furacilin - instructions for medical use - RU No. LP-004036 dated 2017-03-06
Furacilin - instructions for medical use - RU No. LP-003549 dated 2017-02-01
Furacilin - instructions for medical use - RU No. LP-002180 dated 2018-08-16

Synonyms of nosological groups

Furacilin

International non-proprietary name

Nitrofural

Dosage form

Tablets 0.02 g

Compound

One tablet contains

active substance- nitrofural (furatsilin) ​​0.02 g

excipient- sodium chloride 0.8 g

Description

Tablets of yellow or greenish-yellow color with an uneven surface color, flat-cylindrical with a risk and a chamfer.

Pharmacotherapeutic group

Antiseptics and disinfectants. Nitrofuran derivatives. Nitrofural.

ATX code D08AF01

Pharmacological properties

Pharmacokinetics

Easily passes through histohematic barriers and is evenly distributed in fluids and tissues. The main way of transformation in the body is the reduction of the nitro group. It is excreted by the kidneys and partly with bile in

intestinal lumen. The maximum concentration in the urine is reached 6 hours after ingestion.

Pharmacodynamics

Furacilin is an antimicrobial agent. Active against gram-positive and gram-negative bacteria (Staphylococcus spp., Streptococcus spp., Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp., Escherichia coli, Clostridium perfrigens, Salmonella spp., etc.) Effective with the resistance of microorganisms to other antimicrobial agents (not from the group of nitrofuran derivatives). Suppresses the activity of fungal flora. It has a mechanism of action different from other chemotherapeutic agents: microbial flavoproteins restore the 5-nitro group, the resulting highly reactive amine derivatives change the conformation of proteins, including ribosomal ones, and other macromolecules, causing cell death. Resistance develops slowly and does not reach a high degree. Increases the absorption capacity of the reticuloendothelial system, enhances phagocytosis.

Indications for use

minor skin lesions (including abrasions, scratches, cracks, cuts), purulent wounds, bedsores, ulcers

burns II and III degree

furunculosis of the external auditory canal, acute external and otitis media

purulent-inflammatory processes of the paranasal sinuses

angina, stomatitis, gingivitis

Dosage and administration

Outwardly, furatsilin is used in the form of an aqueous 0.02% (1:5000) solution and an alcohol 0.066% (1:1500) solution.

- with purulent wounds, bedsores and ulcers, burns II and III degree, to prepare the granulating surface for skin grafting and for the secondary suture, irrigate the wound with an aqueous solution of furacilin and apply wet dressings

- with chronic purulent otitis, furuncles of the external auditory canal and empyema of the paranasal sinuses apply in the form of drops an alcohol solution of furacilin

- for washing the maxillary (maxillary) and other paranasal sinuses use an aqueous solution of furacilin

- with angina and stomatitis rinsing with an aqueous solution of the drug is prescribed.

To prepare an aqueous solution, 1 tablet of furacilin is dissolved in 100 ml of distilled water. An alcohol solution is prepared in 70% ethanol (1 tablet of furacilin is dissolved in 100 ml of 70% ethyl alcohol). -6 drops into the external auditory canal. For rinsing the mouth and throat - 20 mg (1 tablet) is dissolved in 100 ml of boiled water.

The course of treatment should not exceed 3-5 days. If symptoms persist, it is recommended to consult a doctor.

Side effects

• allergic reactions: pruritus, dermatitis

nausea, vomiting, diarrhea

Contraindications

Increased individual sensitivity to the drug

Allergodermatoses

Drug Interactions

Not installed

special instructions

Pregnancy and lactation

Can be used during pregnancy and lactation.

Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

There are no data on adverse effects on the ability to drive a vehicle or potentially dangerous mechanisms.

Overdose

Not identified

Release form and packaging

10 tablets are placed in a blister-free package made of polyethylene-coated paper.

600 contour non-cell packs with an equal number of instructions for medical use in the state and Russian languages ​​are placed in a cardboard box.

Storage conditions

In a dry, dark place, at a temperature of 15 to 25 ºC.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date.

Terms of dispensing from pharmacies

Without recipe

Manufacturer

Registration certificate holder

OAO Irbit Chemical-Pharmaceutical Plant, Russia

623856, Sverdlovsk region, Irbit, Kirova st., 172.

organization address,accepting claims from consumers on the quality of products (goods)

OAO Irbit Chemical-Pharmaceutical Plant, Russia