Furazolidone: indications for use. Furazolidone: instructions for use for children and adults, indications, dosages Furazolidone for how long can be used

Furazolidone is a drug intended for the treatment of various inflammatory diseases. Its main purpose is the fight against gram-negative aerobic microorganisms. But it has less effect on gram-positive microorganisms. In simple terms, the drug is prescribed for the treatment of persons with various infectious diseases of a wide range: from the organs of the gastrointestinal tract to the skin.

Variety of clinical and pharmacological group

The agent is a derivative of nitrofuran. It belongs to the group of antibacterial agents. Drugs in the related group: Macmirror and Furamag. The action of the drug is aimed at disrupting the activity of bacterial systems. Particularly effective in the fight against the following bacteria:

• streptococci;
• gram-negative rods;
• lamblia;
• Trichomonas.

The history of the use of the drug confirms the fact that it provides significant assistance to the body in confronting intestinal infections. It is an almost indispensable tool in terms of price-quality ratio in the fight against dysentery and typhoid fever.

Active ingredient and other components of the drug

The active substance is the active ingredient of the same name furazolidone. In one tablet it is about 50 milligrams. Manufacturers use as auxiliary components:

• sugar;
• potato starch;
• polysorbate;
• lactose.

Auxiliary components are in the preparation in a very small consistency.

Appearance and packaging of the drug

Tablets are available in the format of ten pieces in a regular package. There are several other alternative forms of release. In pharmacies, you can find 50 tablets in a jar of bright glass or special forms for hospitals and hospitals. In this case, 800 packs are sold together.

The drug and its pharmacological action

The mechanism of pharmacological action primarily depends on the dosage of the drug. Depending on the disease and its severity, various dosages are prescribed. Accordingly, the drug does not have a single mechanism of pharmacological action.

At small doses, Furazolidone will have a bacteriostatic effect. If the dose of the drug is high, then the body will have a general bactericidal effect aimed at the causative agent of a serious illness.

The main mechanism focuses on the reduction of the nitro groups of the drug, which, under the influence of microorganisms, become toxic to bacteria. In the process, nitro groups are converted to amino groups. As a result, with a positive course of the disease, the amino groups begin to gradually destroy the cell membranes of various bacterial microorganisms.

In addition, the action of the drug is aimed at destroying the ability of bacteria not only to grow, but also to reproduce. In fact, the bacteria in the body cease to spread, and the surviving microorganisms are gradually eliminated from the body due to furazolidone therapy.

According to reviews of independent experts, Furazolidone has very little effect as an immunostimulant. The bottom line is that the drug, with prolonged use, is able to increase the activity of leukocytes.

The drug is completely absorbed in the intestine. It is excreted quite well and often unchanged (which is why the patient's urine becomes yellow). It is excreted by 80% by the kidneys. A healthy person does not have problems with the withdrawal of the drug in a natural way.

When is it indicated to use the drug

The main list of diseases is as follows:

• infections of the gastrointestinal tract;
• infections of the genitourinary system;
• treatment of infected wounds and burns.

In particular, the drug has proven its effectiveness in the fight against any unopened forms of foodborne infections. The active substance of furazolidone is able to relieve the symptoms of a wide range of infections of the genitourinary system, including vaginitis, cystitis and trichomonas colpitis.

How to use the drug correctly

The drug is to be used only inside. The tablet must be swallowed completely. Chewing and crushing of the medicinal product is not allowed. In this case, the effectiveness of the action will be reduced, and the drug is much worse absorbed in the intestines. The dosage depends on the disease.

On average, a ten-day course is prescribed for the treatment of foodborne infections. You need to drink four times a day for 150 grams.

In the case of infected burns, a solution is used to treat open wounds. Usually, the drug is used this way only in hospitals and hospitals, where they use their own concentration of the drug, depending on the individual characteristics of the patient.

Cases of overdose

The use of the drug in large doses provokes global liver damage. In advanced cases, the development of toxic hepatitis is theoretically possible. There are no specific remedies to prevent overdose symptoms.

A standard gastric lavage is prescribed. In addition, the use of laxatives is supposed to be inside. It is necessary to carefully monitor your own water and electrolyte balance, since due to poisoning, many useful substances will be excreted from the body. Group B drugs are prescribed for inpatient treatment.

Side effects of Furazolidone

The drug has a fairly wide range of side effects. Most often, patients distinguish the following symptoms:

• nausea;
• vomit;
• allergy.

In some cases, against the background of the use of the drug, a decrease in appetite is manifested. To some extent, side effects always appear with long-term use of Furazolidone. It is recommended to take the tablets before meals and be sure to drink plenty of fluids to reduce the risk of side effects.

If attacks of vomiting overcome several times a day, then it is urgent to consult a doctor for the appointment of an alternative remedy.

Conditions for dispensing from a pharmacy and shelf life

Furazolidone is sold without a prescription and other restrictions. Tablets can be stored at home. They must be kept in a dry and cool place. Important - the complete absence of sunlight. Keep out of the reach of children.

The price of the drug

Furazolidone is one of the best value-for-money remedies for intestinal infections on the pharmaceutical market. The price of the drug, depending on the packaging, varies from 90 to 130 rubles. The average price for one package is 75 rubles in the Russian capital.

Existing drug analogues

Unfortunately, the drug has no analogues for the active substance. In addition, the pills are unique in their price range, if you take poisoning remedies. At the same time, a large number of people in medical practice have described incompatibility with the drug Furazolidone. In this case, the doctor is obliged to prescribe an alternative medicine.

According to the spectrum of action, Ersefuril can be considered the closest analogue. It uses a derivative of Nitrofuran as an active substance. It also has full antimicrobial properties and has earned a positive reputation in the pharmaceutical market.

Ersefuryl is effective in a wide range of diseases of the gastrointestinal tract. In particular, it copes with salmonella and enterobacteria. The drug is available in capsules. There are only 14 capsules in one pack.

The main disadvantage of tablets from a French manufacturer is the high price. The cost of one package varies from 500 to 700 rubles. For one course of treatment, it is usually necessary to purchase several packs.

Furazolidone is a drug used for protozoal invasion of the gastrointestinal tract and skin, as well as for urinary tract infections of bacterial etiology.

The advantages of the agent are the low risk of development of resistance of pathogenic microorganisms, which allows the use in repeated infections. It is possible to use furazolidone both as part of a complex antibiotic therapy regimen and as monotherapy.

Furazolidone - instructions for use for children and adults

During laboratory tests, the antimicrobial activity of the antibiotic against gram-negative shigella and salmonella, some types of gram-positive strains of bacteria (staphylococcus), as well as chlamydia and giardia, was established. However, it does not show sufficient effectiveness in the treatment of mixed infections caused by several types of pathogens. Thus, its appointment in complicated infectious diseases is not advisable.

It should be noted that the antimicrobial activity of furazolidone excludes the possibility of its use in rotavirus infection. The remedy is effective only against bacterial infections or protozoa. This fact is due to its mechanism of anti-infective activity. The mechanism of action is to disrupt the processes of cellular respiration of bacteria or protozoa due to inhibition of the cascade of biochemical reactions in the Krebs cycle (synthesis of tricarboxylic acid). As a result, damage to the cell wall or cytoplasmic membrane occurs, which leads to an active flow of molecules from the environment into the cell, which leads to its swelling and death.

Furazolidone - an antibiotic or not?

Yes, this drug is an antibiotic, the active substance furazolidone belongs to nitrofuran derivatives, a synthetic class of antibacterial agents.

It should be noted that nitrofurans are characterized by a high incidence of adverse reactions with an incorrect dosing regimen, therefore, only the attending physician can prescribe a treatment regimen and dosage after collecting a complete medical history. Self-correction of the duration of treatment and prescribed dosages is unacceptable.

Pharmacological group

Antibacterial agents (derivatives of nitrofuran).

The product is highly effective when administered orally. It is characterized by a short half-life, which does not exceed 2 hours. The main part (up to 95%) of the active ingredient is metabolized and only 5% accumulates in the urine. It is noted that in pathologies of the kidneys, the excretion of the drug takes a much longer amount of time.

Along with antimicrobial activity, it exhibits an immunostimulating effect, activating the work of leukocytes, the cells responsible for phagocytosis - the absorption and digestion of foreign agents.

Composition of furazolidone

The composition of 1 tablet includes 50 mg of the main active ingredient - furazolidone.

Additionally, lactose is indicated in the composition of the product.

Release form

Furazolidone for children is available in the form of granules in glass jars with a measuring cup, packed in cardboard boxes with instructions.

For adults, the drug is available in tablet form, 10 pieces in a foil contour plate. Number of plates: from 2 to 5 in a carton with recommendations for use.

The third form of release - in plastic jars of 50 tablets each.

It should be noted that, regardless of the form of release, the concentration of the active substance is 50 mg per 1 tablet.

Recipe in Latin

Tablets and granules are dispensed in a pharmacy by prescription, like any other antibiotic. On the prescription, certified by the personal seal of the doctor, the full name is indicated. patient and the name of the active ingredient.

Rp.: Furazolidone 50 mg

What is furazolidone used for?

The drug is prescribed for infectious lesions of the gastrointestinal tract with sensitive types of microorganisms.

According to official statistics, more than 90 million cases of dysentery infection with bacteria of the genus Shigella are recorded annually, 700 thousand of which end in death. Therefore, at the first signs of the disease: fever, stomach pain, frequent stools (up to 20 times a day) with an admixture of pus and mucus, you should immediately consult a doctor. When confirming the shigellosis etiology of AII, furazolidone is often prescribed as part of complex therapy.

The use is also justified for paratyphoid - caused by bacteria of the genus Salmonella. Important: regardless of age, if paratyphoid is suspected and diagnosed, the patient must be hospitalized. Treatment is carried out under round-the-clock supervision of a doctor.

Furazolidone is no less effective in bacterial cystitis, as well as in the treatment of urethritis, or the mucous epithelium of the vagina. This fact is due to the sensitivity of bacteria of the Enterobacteriaceae family to furazolidone.

The doctor also prescribes furazolidone for diarrhea, which may be the result of bacterial or protozoal invasion of the human body.

Furazolidone - indications for use

Indications for the appointment of the antibiotic furazolidone are diagnosed forms of infectious lesions of the gastrointestinal tract or urinary system. List of diseases:

• paratyphoid;
• dysentery;
• urethritis;
• giardiasis.

In view of the growth of bacterial resistance to antibiotics, furazolidone for cystitis should be prescribed only after receiving cultures for sensitivity.

Contraindications

The appointment of an antibiotic is unacceptable in case of individual intolerance to the active substance or antibiotics of the nitrofuran group. The minimum age for therapy is 1 month, however, for children under the age of 8 years, treatment should be carried out under continuous medical supervision.

Furazolidone is contraindicated during pregnancy and breastfeeding, as well as in severe kidney pathology. It is taken with caution in violations of the central nervous system, mental disorders and dysfunction of the enzymatic system.

Dosage and method of application of furazolidone

Method of administration: after eating, drinking plenty of boiled water. Chewing tablets is not allowed.

The calculation of the dosage of furazolidone for children is carried out strictly by the attending physician, taking into account the age and weight of the child.

For patients aged 1 to 8 years, the allowable dose should not exceed 0.15 g, and the maximum duration of treatment should not exceed 10 days. It is also necessary to take three-day breaks after 3-4 days of admission.

Dosage formula for children over 8 years old: 5 mg per 1 kg. Important: the daily dose is divided into 4 doses.

Dosage regimen for adults with acute intestinal infections: 1-3 tablets 3-4 times a day. The frequency of administration is determined by the doctor depending on the severity of the disease and the patient's condition. The duration of the course should not exceed 10 days.

For the treatment of giardiasis and urethritis, 2 tablets are used 4 times a day.

Important: the maximum allowable daily dose is 800 mg.

Such a large number of tablets needed per day is explained by the rapid absorption and half-life of the active ingredient from the human body.

Side effects of furazolidone

It was noted that with a properly selected dose and frequency of administration, the frequency of manifestation of adverse reactions is minimal. The severity of negative symptoms depends on the degree of sensitivity of the patient to the active ingredient. The list of possible reactions of the body:

• indigestion: nausea, vomiting, loss of appetite and abdominal pain:
• allergic reactions of immediate type: redness of the skin, itching.

If the first signs of intolerance appear, it is necessary to cancel its use, and also consult a doctor to correct the antibiotic therapy regimen and symptomatic treatment.

Furazolidone during pregnancy and breastfeeding

Furazolidone is not recommended during pregnancy. The medicine is prescribed only if it is impossible to select an alternative treatment for an infection that poses a real threat to the life of the mother and child.

In view of the ability of the active ingredient to penetrate into breast milk and adversely affect the formation of the normal symbiotic microflora of the child, if it is necessary to prescribe a medication, breastfeeding should be stopped. The resumption of lactation is possible after the complete removal of the antibacterial agent from the mother's body (at least 1 day after cancellation).

Furazolidone and alcohol - compatibility and consequences

The combined use of antibiotics and alcohol-containing drinks is strictly prohibited. The consequences of the use of alcohol and furazolidone are disulfamimopodobny reactions. As a result, the patient often has a high fever, headaches, a sharp decrease in blood pressure, increased heart rate, nausea and vomiting, convulsions, and panic attacks.

Moreover, alcohol and antibiotics compete for metabolism by similar groups of enzymes. As a result, their incomplete decomposition is noted, which leads to acute intoxication of the body. The condition of a sick person worsens significantly, and treatment is ineffective.

Furazolidone analogues

Currently, there are no complete or partial analogues in terms of chemical composition.

What is better furazolidone or enterofuril?

The main active ingredient of enterofuril is nifuroxazide, which belongs to antibacterial agents with a wide range of sensitive microorganisms. The minimum age allowed is 3 years. In view of the fact that one of the auxiliary components is fructose, the drug is contraindicated in people with intolerance and diabetes.

A distinctive advantage of enterofuril is the possibility of therapy during breastfeeding after consultation with a doctor.

The price of enterofuril is much higher and amounts to 350 rubles for the capsule form, 400 rubles for the suspension. Therefore, in the absence of contraindications for the appointment of furazolidone, it is the preferred form.

In addition, furazolidone is used for cystitis, urethritis, dysentery and paratyphoid, in turn, the only indication for the appointment of enterofuril is diarrhea of ​​​​bacterial etiology.

Furazolidone is an antimicrobial drug of the nitrofuran series with an impressive therapeutic "experience": it was first synthesized back in 1953 by Soviet scientists S. A. Giller and R. Yu. Kalnberg.

The mechanism of action of the drug is blocking the enzyme systems of bacteria, disrupting the synthesis of its natural components, and slowing down the reproduction process. In high doses, it has a bactericidal effect. It has a therapeutic effect in most infectious diseases (with the exception of anaerobic infections).

The drug is used to treat intestinal infections, diseases of the genitourinary system and is used for massive skin lesions to prevent the development of an infectious process.

Clinical and pharmacological group

Antibacterial drug, a derivative of nitrofuran.

Terms of sale from pharmacies

Can buy by prescription.

Price

How much does Furazolidone cost in pharmacies? The average price is at the level of 120 rubles.

Composition and form of release

Furazolidone is available in the form of yellow, flat-cylindrical tablets with a chamfer on one side, 10 pieces in a contour package (2-3), in a cardboard box. Also, tablets can be packed in cans of polymeric material of 50 pieces. A detailed instruction with a description of the characteristics is attached to the drug.

Each tablet contains 50 mg of the active ingredient - Furazolidone, as well as a number of excipients.

Pharmacological effect

Furazolidone is a synthetic derivative of 5-nitrofurforol. The drug is effective in the treatment of inflammatory diseases caused by gram-negative aerobic bacteria. Gram-positive aerobic bacteria are less sensitive to it, as are fungi and protozoa. Anaerobic pathogens are insensitive to Furazolidone.

The pharmacological action of this drug depends on the dosage. At low doses, Furazolidone has a bacteriostatic effect, and with increasing doses, it has a bactericidal effect. The antimicrobial action is based on the fact that the nitro groups that make up the drug are reduced to amino groups under the influence of microbial enzymes and become toxic to them. The resulting amino groups are capable of disrupting the integrity of bacterial cell membranes and blocking many processes in them. The result of such exposure is the loss of the ability of microorganisms to reproduce.

Furazolidone has a slight immunostimulatory effect. This drug is able to increase the phagocytic activity of leukocytes and compliment titer.

After taking Furazolidone inside, it is quickly and almost completely absorbed in the intestine. Therapeutic concentrations of the drug in the blood persist for 5-6 hours after taking the drug. The concentration of Furazolidone in the cerebrospinal fluid is almost equal to the concentration in the blood. The concentration of the drug in the intestine is also high. It is excreted mainly by the kidneys in an unchanged state or as metabolites.

Indications for use

This drug is used to treat inflammatory and infectious diseases of the genitourinary system, gastrointestinal tract and skin.

According to the instructions, Furazolidone is used to treat the following diseases:

1. Diarrhea caused by infectious causes, in particular food poisoning;
2. Trichomonas infection;
3. Typhus and paratyphoid;
4. Bacillary dysentery;
5. Enterocolitis;
6. Infected burns and wounds of the skin.

Contraindications

Furazolidone contraindications:

• congenital deficiency of glucose-6 phosphate dehydrogenase (possibly inhibition of hematopoiesis);
• the age of the child is less than 1 month;
• individual hypersensitivity;
• critical stage of renal failure.

Relative contraindications (the benefits of use must justify the possible harm, the drug is prescribed by a doctor in case of emergency):

• transport management, work on machine tools, etc. (furazolidone can cause impaired coordination of movements);
• the age of the child (it is undesirable to use children under one year old);
• pregnancy and breastfeeding (it may be necessary to stop breastfeeding);
• liver disease;
• insufficiency of the excretory function of the kidneys;
• neurological diseases (nitrofurans can have a neurotoxic effect);
• age up to 3 years (in the dosage form of furazolidone tablets).

Appointment during pregnancy and lactation

The drug belongs to category C. This means that in the study of the drug in animals, an adverse effect on the fetus was noted, but there are no data on the effect on the human fetus.

According to the instructions, the drug is contraindicated during pregnancy. It can be prescribed only for vital necessity, taking into account the expected and the risk to the fetus.

Dosage and method of application

As indicated in the instructions for use, Furazolidone tablets are taken orally after meals. The tablet is recommended to be swallowed at once, without biting, washing down with a sufficient amount of water. The dose of the drug and the duration of the course of treatment is determined by the doctor on an individual basis for each individual patient.

For dysentery, food poisoning, traveler's diarrhea and paratyphoid, adults are prescribed 2-3 tablets of the drug 4 times a day, the maximum daily dose of the drug should not exceed 800 mg. The duration of the course of treatment with the drug is 5-10 days.

For the treatment of giardiasis, adults are prescribed 2 tablets of the drug 4 times a day. For children under 12 years of age, the dose is calculated individually, depending on body weight - 10 mg / kg. The resulting dose of the drug is divided into equal parts for 3-4 doses.

Adverse reactions

The drug Furazolidone has little toxicity, is well tolerated, but can still cause some adverse reactions of the body, including:

• loss of appetite;
• nausea, urge to vomit;
• allergic reactions of the skin;
• pain in the epigastric region.

The appearance of such symptoms often becomes a reason for discontinuing the drug and prescribing analogues. The closest analogues in terms of the mechanism of action are drugs such as Nifuroxazide, Enterol, Enterofuril. In their composition, such drugs contain another active ingredient, so only a doctor can prescribe them.

Overdose

During an overdose of the drug, patients may experience toxic liver damage and the development of acute toxic hepatitis, polyneuritis may develop on the hematotoxic effect of the drug. There is no antidote for the drug.

If a case of overdose occurs, it is necessary to wash the stomach and take enterosorbent and saline laxatives. If there is a need, then they support the water and electrolyte balance, sometimes it is necessary to prescribe antihistamines and vitamins included in group B.

If an overdose occurs in a patient with impaired renal function, hemodialysis should be performed.

special instructions

Before you start using the drug, read the special instructions:

1. Increases sensitivity to the action of ethanol.
2. Aminoglycosides and tetracycline enhance antimicrobial properties.
3. Medicines that alkalinize urine reduce the effect, while acidifiers increase it.
4. For the prevention of neuritis with prolonged use, it is necessary to combine with B vitamins.
5. During treatment, precautions should be observed, as with the use of monoamine oxidase inhibitors, namely: exclusion from the diet of foods containing tyramine: cheese, cream, beans, pickled herring, strong coffee.

Compatibility with other drugs

Furazolidone in combination with ethanol can lead to the development of disulfiram-like reactions, and therefore their simultaneous administration is not recommended. Antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, phenylephrine, tyramine can cause a sharp increase in blood pressure.

Furazolidone is an effective and affordable pharmacy drug with antiprotozoal and antimicrobial effects. The tool is characterized by a wide range of applications in various diseases and inflammatory processes that have a bacterial etiology. Furazolidone is prescribed for poisoning with low-quality products or food bacteriotoxicosis.

Furazolidone tablets in case of poisoning have a negative destructive effect on pathogenic microorganisms that caused the characteristic symptoms. The active substance of the drug is Furazolidone (Furazolidone) - a derivative of the antibacterial agent nitrofuran.

Additional or auxiliary substances in the composition of the drug are:

• lactose monohydrate;
• sucrose;
• colloidal silicon dioxide;
• calcium stearate;
• polysorbate;
• potato starch.

The action of Furazolidone is to disrupt the activity in the enzyme systems of microorganisms. Nitrofuran has a negative effect on the respiratory function of cells, stops the process of nucleic acid biosynthesis, which provokes the destruction of the protein coat of bacteria and their death. The drug reduces the release of toxins by destroyed microorganisms.

Unlike many other antimicrobial drugs, Furazolidone activates the protective function of the body.

The drug has a negative effect on the following microorganisms:

• staphylococci;
• streptococci;
• salmonella;
• coli;
• shigella (causative agent of dysentery);
• Klebsiella infection;
• enterobacter;
• lamblia;
• Trichomonas.

Instructions for use for intoxication

Furazolidone is prescribed for a number of problems with the functioning of the gastrointestinal tract, which have arisen due to infection entering the body and its activity in the digestive organs.

Indications for the use of an antimicrobial drug are symptoms of poisoning with poor-quality food and intoxication of the body:

• diarrhea;
• nausea;
• vomit;
• spasms in the stomach and intestines;
• fever and headache on the background of intoxication.

It is necessary to drink Furazolidone tablets in case of food poisoning, strictly observing the doses indicated in the instructions. The drug has a side effect in case of overdose.

You can not take the medicine for more than 10 days. Children without a doctor's prescription are not recommended to use the medicine. The dosage depends on the age, weight of the child and the severity of the disease. Tablets should be taken after meals with plenty of water.

The interaction of alcohol and this drug from a pharmacy. Despite frequent warnings about the incompatibility of drugs and alcohol, there are cases of the use of Furazolidone in the complex therapy of alcohol dependence.

In patients with problems with alcohol, after taking the tablets for 10 days, a persistent aversion to drinks is developed. This reaction is caused by hypersensitivity to alcohol-containing liquids. An addicted person develops severe nausea, headache, vomiting, skin rashes, and other unpleasant symptoms when drinking small amounts of alcohol.

In connection with such a reaction of Furazolidone with alcohol, the drug belongs to sensitizing drugs.

Dosage and overdose

For adults with food poisoning (bacterial food poisoning), bacterial diarrhea, the daily norm is 0.8 g of Furazolidone (0.1-0.15 g 4 times a day). The course of treatment is from 5 to 10 days.

The drug can be prescribed to children not younger than 5 years of age. Depending on age, weight and well-being, the dose of medicine for a child can be 1/4, 1/2 part or a whole tablet 4 times a day. Treatment lasts no more than 10 days.

Improvement in well-being is observed after 2-5 days with regular use of the drug in accordance with the recommended dosage. If there is no effect from therapy after 5-7 days of taking the drug, it should be concluded that the pathogen does not show sensitivity to the active substance. In this case, you should stop taking the tablets and contact your doctor for a prescription for another medication.

Furazolidone belongs to monoamine oxidase inhibitors (MAOIs) and its use is not combined with the use of other MAO inhibitors, sympathomimetics (adrenomimetics of indirect action), antidepressants, Amphetamine, Phenylephrine, Ephedrine. When these drugs interact with nitrofuran, there is a high risk of a strong and sharp increase in blood pressure.

An overdose of the drug is possible if the dose specified in the instructions is exceeded and the duration of therapy is increased. In this case, a toxic effect on the liver (toxic hepatitis) may develop, as a result of which the tissues become inflamed and the cells of the organ die.

If the instructions regarding the use of the drug are not followed, there may be a violation of the function of blood cells, a change in the composition of the blood due to the hemotoxic effect of the active substance of the drug.

An overdose is dangerous with a neurotoxic effect on multiple nerve endings of the peripheral nervous system, which leads to a violation of muscle nutrition and a decrease in their sensitivity. In difficult cases, complete atrophy of some parts of the muscle tissue is possible.

In case of an overdose, it is necessary to perform a gastric lavage, take sorbents (activated carbon, Enterosgel, Polyphepan, Enterodez, Smecta, Enterofuril) and saline laxative (Sodium sulfate, Magnesium sulfate, Carlsbad salt, Magnesium hydroxide). It may be necessary to normalize the water and electrolyte balance, you should consult a doctor. The doctor may prescribe the use of antiallergic drugs and vitamin B.

Based on the reviews of the drug, we can conclude that Furazolidone poisoning pills are a fast-acting and effective drug. In the vast majority of cases, a significant improvement in the condition of patients with food poisoning is observed within a few hours after taking the drug.

It is important not to overdo it with the dosage in order to avoid unpleasant consequences. The advantage of this medication is its availability, low cost and effectiveness.

The effect of Furazolidone increases with its simultaneous use with antibiotics of the tetracycline group and aminoglycosides. Sometimes this combination is used in complex therapy for the rapid suppression of pathogenic microflora in the body.

Contraindications

For the treatment of indigestion, Furazolidone should not be used if there is an individual intolerance to the active substance or one of the auxiliary components that make up the medication.

Contraindication is the treatment with the drug of a child under 5 years of age. Do not use tablets in patients with renal and lactase deficiency.

Exclusively as directed by a doctor, furazolidone poisoning therapy is allowed for patients with impaired renal function and problems in the functioning of the nervous system.

When taking medication during pregnancy, you should consult with your doctor. The doctor will make a decision based on the predominance of benefits for the expectant mother over the possible risk to the normal course of pregnancy and the health of the child.

Women who are breastfeeding babies, if necessary, use this pharmacy, it is recommended to interrupt feeding for the period of treatment of drug poisoning. This is due to the possible effect of nitrofuran on the baby's blood composition and the development of anemia or methemoglobinemia in him. How many days the treatment will continue, and what dosage of the drug should also be determined by the specialist.

Furazolidone refers to nitrofuran derivatives and is a drug that has a pronounced antimicrobial and antiprotozoal effect. Furazolidone belongs to monoamine oxidase inhibitors (MAO inhibitors).

The advantages of furazolidone include a wide range of organisms sensitive to the active substance, activation of the human immune system and a low rate of formation of resistance to pathogenic agents, which allows repeated courses of treatment.

The most common form of release of furazolidone is tablets. 1 tablet of Furazolidone is 50 mg of the active ingredient. For children, the drug is available in the form of granules, used after preparing a suspension (mixture). For veterinary purposes, furazolidone is used in powder form.

In tablet form, furazolidone is presented on the markets in packs of 10 and 20 pieces with a price depending on the amount of the drug: 50-65 rubles. and 90-120 rubles. respectively.

Pharmacokinetics and action of the drug

The active substance of the drug has a devastating effect on the process of cellular respiration of a pathogenic microorganism, suppresses the Krebs cycle (synthesis of tricarboxylic acid), inhibits basic biological and chemical processes in pathogenic microorganisms, which leads to damage to cell membranes or their cytoplasmic membranes. In addition to the general detrimental effect as a result of taking the full course of the drug, the patient's well-being also improves in the process of taking it as a result of a decrease in the production of toxins by microorganisms.

The immunostimulating effect is based on the ability of nitrofurate derivatives to activate phagocytes, cells that attack foreign agents.
Pharmacokinetic features of the drug: high absorption when taken orally, the ability to penetrate and accumulate equally in the blood and in the cerebrospinal fluid, which allows it to be used in the treatment of diseases that cause inflammation in the membranes of the brain.

The metabolic processes of the drug are concentrated in the liver, the excretion of the metabolite is mostly carried out through the urinary system, the smaller one leaves the body with feces.

When is furazolidone used?

The drug has proven efficacy against a number of protozoa and is used for infections caused by some gram-positive and gram-negative microorganisms, with the exception of pathogens of anaerobic and purulent inflammatory processes.
It is effective in the food type of toxicoinfections, paratyphoid, bacillary dysentery, giardiasis, urinary tract infections (pyelitis, urethritis) caused by Trichomonas, as well as in the treatment of burns and infected skin surfaces in operational medicine.

Contraindications to the use of the drug

In accordance with the instructions for the use of furazolidone, the appointment of this drug to children under the age of 1 year, the period of gestation, lactation, as well as in the terminal stage of renal failure and with severe sensitivity to the nitrofuran group, is absolutely contraindicated. With caution, therapy is prescribed for pathologies of the central nervous system, dysfunctions of the liver and kidneys, and some enzyme deficiencies.

Doses of the drug according to age and diseases

In basic therapy, the drug is taken orally after a meal. Furazolidone should be taken with a sufficient amount of liquid. In surgical practice, local forms of exposure to the affected surface are often used. The course of therapy is 7-10 days.

Depending on the degree of sensitivity to the active substance, there may be side effects from the gastrointestinal tract (appetite disorder, nausea, vomiting); nervous system (neuritis, polyneuritis); skin symptoms of an allergic reaction to nitrofuran derivatives (urticaria, pruritus, swelling).

The combination of furazolidone with other drugs

Antibiotics of the tetracycline group and aminoglycosides are used in combination therapy, as they increase the effect of furazolidone on pathogenic microorganisms.

Preparations of antidepressant groups, other MAO inhibitors, phenylephrine, amphetamine, ephedrine-containing agents in combination with nirofurans provoke.

Alcohol-based preparations and alcoholic beverages, when taken simultaneously with nitrofuran derivatives, cause disulfamiro-like reactions, accompanied by fever, a rush of blood to the head, a drop in blood pressure, tachycardia, nausea, and panic attacks.

Prevention of side effects

In connection with the possible effect of the drug on the nervous system and liver tissue during long courses of treatment, CNS support is prescribed in the form of courses of combined B vitamins, as well as hepatoprotectors.