How to take Aquadetrim for adults in drops. Aquadetrim vitamin D3, Solution

In this article, you can read the instructions for using the drug Aquadetrim. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Aquadetrim vitamins in their practice are presented. A big request to actively add your reviews about the drug: did the medicine help or not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Akvadetrim's analogs in the presence of the available structural analogs. Use for the treatment of vitamin D3 deficiency, rickets and osteoporosis in adults, children (including infants and newborns), as well as during pregnancy and lactation. The composition of the drug.

Aquadetrim- a drug that regulates the exchange of calcium and phosphorus. Vitamin D3 is an active anti-rachitic factor. The most important function of vitamin D is to regulate calcium and phosphate metabolism, which promotes mineralization and skeletal growth.

Vitamin D3 is the natural form of vitamin D, which is formed in the human skin upon exposure to sunlight. Compared to vitamin D2, it is characterized by a 25% higher activity.

Colecalciferol plays a significant role in the absorption of calcium and phosphate in the intestine, in the transport of mineral salts and in the process of bone calcification, and also regulates the excretion of calcium and phosphate by the kidneys.

The presence of calcium ions in the blood in physiological concentrations ensures the maintenance of muscle tone of the skeletal muscles, myocardial function, promotes the conduction of nervous excitation, and regulates the process of blood coagulation.

Vitamin D is necessary for the normal functioning of the parathyroid glands, and is also involved in the functioning of the immune system, affecting the production of lymphokines.

Lack of vitamin D in food, impaired absorption, calcium deficiency, as well as insufficient exposure to the sun during the period of rapid growth of the child leads to rickets, in adults - to osteomalacia, in pregnant women, symptoms of tetany, violation of the processes of calcification of the bones of newborns may occur.

An increased need for vitamin D occurs in women during menopause, as they often develop osteoporosis due to hormonal disorders.

Compound

Colecalciferol (vitamin D3) + excipients.

Pharmacokinetics

Aquadetrim aqueous solution is absorbed better than an oil solution (this is important when used in premature babies, because in this category of patients there is a lack of production and flow of bile into the intestine, which disrupts the absorption of vitamins in the form of oil solutions). After oral administration, cholecalciferol is absorbed from the small intestine. Metabolized in the liver and kidneys. Penetrates through the placental barrier. It is allocated with breast milk. Colecalciferol accumulates in the body. It is excreted by the kidneys in a small amount, most of it is excreted in the bile.

Indications

Prevention and treatment:

• vitamin D deficiency;
• rickets and rickets-like diseases;
• hypocalcemic tetany;
• osteomalacia;
• metabolic osteopathies (hypoparathyroidism and pseudohypoparathyroidism);
• osteoporosis, incl. postmenopausal (as part of complex therapy).

Release forms

Drops for oral administration 10 ml (aqueous solution).

Instructions for use and dosage

The dose is set individually, taking into account the amount of vitamin D that the patient receives in the diet and in the form of drugs.

The drug is taken in 1 spoonful of liquid (1 drop contains 500 IU of colecalciferol).

In order to prevent full-term newborns from 4 weeks of life to 2-3 years, with proper care and sufficient exposure to fresh air, the drug is prescribed at a dose of 500-1000 IU (1-2 drops) per day.

Premature babies from 4 weeks of age, twins and children living in adverse conditions are prescribed 1000-1500 IU (2-3 drops) per day.

In the summer, the dose can be reduced to 500 IU (1 drop) per day.

Pregnant women are prescribed 500 IU (1 drop) per day throughout pregnancy, or 1000 IU per day, starting from the 28th week of pregnancy.

In the postmenopausal period, 500-1000 IU (1-2 drops) are prescribed per day.

For the purpose of treating rickets, the drug is prescribed daily at a dose of 2000-5000 IU (4-10 drops) per day for 4-6 weeks, depending on the severity of rickets (1, 2 or 3) and the course of the disease. In this case, the patient's clinical condition and biochemical parameters (calcium, phosphorus, alkaline phosphatase activity in the blood and urine) should be monitored. The initial dose is 2000 IU per day for 3-5 days, then, with good tolerance, the dose is increased to individual treatment (usually up to 3000 IU per day). A dose of 5000 IU per day is prescribed only for severe bone changes. If necessary, after a 1-week break, the course of treatment can be repeated.

Treatment should be continued until a clear therapeutic effect is obtained, followed by a transition to a prophylactic dose of 500-1500 IU per day.

In the treatment of rickets-like diseases, 20,000-30,000 IU (40-60 drops) per day are prescribed, depending on age, body weight and severity of the disease, under the control of blood biochemical parameters and urinalysis. The course of treatment is 4-6 weeks.

In the treatment of postmenopausal osteoporosis (as part of complex therapy), 500-1000 IU (1-2 drops) per day are prescribed.

Side effect

• loss of appetite;
• nausea, vomiting;
• headache, muscle and joint pain;
• constipation;
• dry mouth;
• polyuria;
• weakness;
• mental disorder, incl. depression;
• weight loss;
• sleep disturbance;
• temperature rise;
• protein, leukocytes, hyaline cylinders appear in the urine;
• an increase in the level of calcium in the blood and its excretion in the urine;
• possible calcification of the kidneys, blood vessels, lungs;
• hypersensitivity reactions.

Contraindications

• hypervitaminosis D;
• hypercalcemia;
• hypercalciuria;
• urolithiasis (formation of calcium oxalate stones in the kidneys);
• sarcoidosis;
• acute and chronic kidney disease;
• kidney failure;
• active form of pulmonary tuberculosis;
• children's age up to 4 weeks;
• hypersensitivity to vitamin D3 and other components of the drug (especially benzyl alcohol).

Use during pregnancy and lactation

During pregnancy, Aquadetrim should not be used in high doses due to the possibility of a teratogenic effect in case of an overdose.

With caution, Aquadetrim should be prescribed during lactation, because. when using the drug in high doses in a nursing mother, symptoms of an overdose in a child may develop.

During pregnancy and during breastfeeding, the dose of vitamin D3 should not exceed 600 IU per day.

Use in children

Contraindicated in children under 4 weeks of age.

special instructions

When prescribing the drug, it is necessary to take into account all possible sources of vitamin D.

The use of the drug for therapeutic purposes in children should be carried out under close medical supervision and adjust the dosage regimen during periodic examinations, especially in the first months of life.

Long-term use of Aquadetrim in high doses or use of the drug in loading doses can lead to chronic hypervitaminosis D3.

Do not use Aquadetrim and calcium in high doses at the same time.

Control of laboratory indicators

When using the drug for medicinal purposes, it is necessary to control the level of calcium in the blood and urine.

drug interaction

With the simultaneous use of Aquadetrim with antiepileptic drugs, rifampicin, cholestyramine, the absorption of cholecalciferol is reduced.

With the simultaneous use of Aquadetrim and thiazide diuretics, the risk of developing hypercalcemia increases.

Simultaneous use of Akvadetrim with cardiac glycosides may enhance their toxic effect (increased risk of developing cardiac arrhythmias).

Analogues of the drug Akvadetrim

Structural analogues for the active substance:

• Vigantol;
• Videhol;
• Videhol solution in oil;
• Vitamin D3;
• Vitamin D3 100 SD/S dry;
• Vitamin D3 Bon;
• Vitamin D3 aqueous solution;
• Cholecalciferol.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases that the corresponding drug helps with and see the available analogues for the therapeutic effect.

With the onset of cold, low-sunshine days, doctors recommend giving children vitamin D. One of the most common drugs is Aquadetrim. Instructions for use for newborns describe in detail the composition and features of the use of the drug.

Why Aquadetrim for a child?

All life on earth cannot grow and develop normally without sunlight and heat. When it is not enough, problems arise. For a person, sunlight is especially important, under its action vitamin D3 is produced in the body. This substance helps in the absorption of calcium.

Often, mothers hide newborns from the sun, fearing overheating and burns. But exposure to ultraviolet rays is vital for babies. Moderate sun exposure is very beneficial for both your baby and you. The amount of vitamin D3 in breast milk increases significantly. In the summer, go outside in the morning or evening. The sun at this time is soft, not scorching.

In the cold season, it is not so easy to “catch” enough ultraviolet radiation. Therefore, pediatricians usually recommend taking medicines containing vitamin D3. For example, Akvadetrim.

Whether to take it or not is purely your decision, since there are both positive and negative effects of the drug. Let's figure it out!

Colecalciferol (another name for vitamin D3) is necessary for a growing body because:

• It contributes to the mineralization of bones, their saturation with calcium, the correct formation of the skeleton, the musculoskeletal system. And this is important, among other things, so that the baby gets up on his feet in a timely manner and begins to walk. Read the current article: When does a child start walking?>>>.
• Ensures normal growth of teeth.
• Necessary for the proper functioning of the digestive system. What to do if not everything is in order, for example, suffer from colic, read the article: Cure for colic in newborns >>>.
• It is essential for the normal functioning of the parathyroid glands.
• Necessary for the work of the heart, blood vessels, is involved in blood coagulation.

Instruction

Aquadetrim is an aqueous solution of vitamin D3 used for newborns, children and adults. The drug is a liquid, colorless, transparent, smells like anise, is taken orally. Produced in dark glass bottles with a dropper dispenser for easy use. Volume 10 ml.

Detailed instructions are attached to each jar of Aquadetrim, containing information on the composition, direction of exposure to the body, form of release, shelf life and shelf life, storage conditions.

Indications and possible side effects, contraindications are described. Detailed recommendations for use for different age categories are given: for adults, children.

Indications for use

The purpose of the drug treatment and prevention of diseases, caused by a lack of vitamin D3. These include:

1. Rickets-like conditions, rickets. It is manifested by a curvature of the limbs, a flattened abdomen, deformity of the skull, and a disorder of the nervous system. Read more in the article Signs of rickets in infants >>>;
2. Osteomalacia is a softening of the bones. In newborns, it is manifested by deformation of the skull. The fontanel becomes soft;
3. Hypocalcemic tetany - muscle cramps due to an imbalance of minerals. calcium and phosphorus. The concentration of the first in the blood is significantly reduced;
4. Metabolic osteopathy is a systemic skeletal disease;
5. Osteoporosis is characterized by increased bone fragility.

Side effects, contraindications

Aquadetrim may cause an allergic reaction. Hypervitaminosis, as a rule, occurs with an overdose. But its symptoms can also be observed with individual intolerance. Possible side effects include:

• allergic reactions;
• loss of appetite, (read a useful article: The child does not eat well, what to do?>>>);
• weight loss;
• temperature rise;
• pain in the joints, muscles, headaches;
• nausea, vomiting;
• constipation (read the current article: What to do if the newborn does not poop?>>>);
• general weakness;
• mental health problems such as depression;
• sleep disorder (important article: Why do children sleep poorly?>>>);
• changes in urine tests: the appearance of protein, hyaline casts, the growth of leukocytes, in the blood: an increase in calcium levels;
• development of calcification of vessels, lungs, kidneys is possible.

Aquadetrim for newborn healthy children up to a month usually not applicable due to the high likelihood of side effects. In children under one year old, it is difficult to identify side effects, they cannot tell what hurts and worries. But if your child has become lethargic, refuses to eat, does not sleep well, stop taking the remedy.

The tool has contraindications. It cannot be used for:

1. Hypercalcemia - an increased content of calcium in the blood plasma;
2. Excess vitamin D;
3. Hypercalciuria - an excess of calcium in the urine;
4. Urolithiasis - the formation of solid formations in the urinary organs;
5. Sarcoidosis - a systemic disease, the formation of inflammatory nodules in organs and tissues;
6. Kidney diseases, acute, chronic;
7. kidney failure;
8. Tuberculosis of the lungs in active form;
9. Newborns up to one month;
10. Hypersensitivity to the components of the drug.

Can Aquadetrim be given to newborns? Not according to the instructions. After all, a newborn is a child up to 28 days old. But there are conditions in which the use of vitamin D3 is shown to children from a week of life.

For example, if a child was born prematurely, lives in an unfavorable environment, or twins were born. The decision on the use of the drug is made by specialists on the basis of the examination, the results of the tests. Let's be honest - to whom these surveys were conducted? I have three children and NONE of them had any examinations when prescribing the drug.

It is mandatory to make a record in the pediatric card that recommendations have been given to give the child Aquadetrim. Often it is not even noticed that the child is allergic.

How to apply?

If you, even after reading all the contraindications and side effects, decide to give your child this drug, then discuss this issue with your doctor. The single and daily dose of Aquadetrim is determined by the doctor individually in each case. Features of the application depend on age, purpose of admission (prevention of the disease or its treatment), severity. Before taking the required number of drops must be dissolved in a spoonful of water.

How to give Aquadetrim to a newborn? Often young children cannot, do not know how or do not want to drink from a spoon. In such cases, mothers come up with different ways. For example, they drip Aquadetrim onto a pacifier, their nipple before feeding, into expressed milk or directly into the baby's open mouth.

• As a preventive measure, the drug is indicated for newborns older than a month and children under 3 years old, one or two drops per day. It is usually recommended to drink the remedy in the morning. Premature babies, twins, and those living in poor conditions should receive two to three drops daily;
• In summer, the dose can be halved. Sometimes pediatricians stop taking Akvadetrim for normally developing children from May to September, provided they have sufficient exposure to the sun;
• Pregnant women are recommended to take the drug drop by drop for all 9 months or two after 27 weeks. Women during menopause take Aquadetrim in the amount of 1-2 drops per day.

In the treatment of diseases associated with a lack of vitamin D3, the drug is prescribed individually in much larger doses. In the process of treatment, it is necessary to control the indicators of blood and urine tests.

Aquadetrim and its analogues: which is better?

How much does Aquadetrim cost ? The drug is produced in Poland . The price in Russia is from 165 to 218 rubles. The cost of analogues:

1. Vitamin D3 (Russia) - about 100-250 rubles, depending on the form and volume of release;
2. Vigantol (Germany) - from 200.

As you can see, there is no noticeable difference in price. What to give a child and whether it is necessary is a strictly individual question. No two newborns are the same, each child has its own characteristics.

Today, many formulas that replace breast milk contain vitamins, including D3. This should be taken into account when deciding whether to take the drug Akvadetrim or its analogue.

What is the difference between the means?

• Aquadetrim is an aqueous solution containing a number of additives. The main controversy is about benzyl alcohol - a preservative in the composition of the drug. Many believe that this substance has the same properties and harm as ethyl. The word "alcohol" is so regarded;

But few people know that, for example, glycerin is also alcohol. The danger of using Akvadetrim is that individual intolerance or side effects may occur. For example, many note sleep disturbance and the occurrence of constipation in newborns when taking Aquadetrim.

• Vigantol is an oily solution of vitamin D3. There is an opinion that in this form, colcalciferol is better absorbed. But the drug also has contraindications, for example, diseases of the biliary tract, individual intolerance, and side effects - the same constipation, nausea, impaired kidney function;

Do not give D3 to a child without the advice of a pediatrician. Pay attention to the condition of the fontanel, skull, legs of your newborn child. If there are signs of rickets, go to the doctor to pick up the drug.

When taking Aquadetrim, monitor the reaction: behavior, appetite, stool of a newborn or older child. If there are side effects, consult your doctor, try an analogue of the drug. If it doesn't fit, don't fret. Many children do not take vitamin D3 and do not get sick with rickets, they grow and develop normally.

mom reviews

Tatyana, 35 years old.

The eldest daughter was not given drugs with D3, the child is absolutely healthy. With the youngest, I wanted to do everything right, on the advice of a doctor. Therefore, the prevention of rickets was approached responsibly. Started taking Akvadetrim. I can’t say that my daughter really liked it, but she didn’t spit it out. A few days later there were problems with sleep, she became capricious. I immediately thought of Aquadetrim. They stopped giving, the child sleeps normally.

Olga, 26 years old.

On the recommendation of a pediatrician on cloudy days, she gave her son Aquadetrim. On the third day there was constipation, very unpleasant. After discontinuation of the drug, the stool recovered. Now I'm afraid that we do not carry out the prevention of rickets. What to do?

Irina, 33 years old.

She gave Akvadetrim to both her eldest daughter and her youngest. Didn't notice any negative reactions. I think it all depends on the child. One is suitable for a water-based drug, another for an oil one, and a third for none.

As you can see, reviews on the use of Akvadetrim are different. Everything is individual.

From my own experience: I did not give vitamin D3 to any of my children. In case of problems with rachitic manifestations, I would consult a doctor and, first of all, go to a homeopath to correct calcium-phosphorus metabolism. So far, it seems to me that these drugs have too many side effects to prevent them.

It is possible to spoil the child's gastrointestinal tract in such a way that it will take more than one month to restore it.

Every mother wants her child to grow up healthy and strong. And for this, mothers go to any tricks, such as hardening, baby swimming, vitamins and other means of prevention.

One of the first means that the baby has to deal with in a new life is aquadetrim. It is his pediatricians who are prescribed as a prophylaxis in the autumn-winter period, or according to indications.

Let's see what is aquadetrim for newborns, reviews of which are very controversial.

Surely, many of you remember how in childhood mothers were forced to drink fish oil - unpleasant in taste, but very useful. The kids of the modern generation are spared from this procedure: aquadetrim has replaced fish oil.

It contains colcalciferol, or in other words vitamin D3, and auxiliary components are also present:

• benzyl alcohol;
• lemon acid;
• sucrose;
• macrogol glyceryl ricinoleate;
• anise flavor;
• sodium hydrogen phosphate dodecahydrate;
• purified water.

Aquadetrim helps to regulate calcium and phosphorus metabolism in the body of crumbs, which contribute to the normalization of metabolism, strengthening of bone tissue and normal growth of the skeleton. The minerals included in its composition are the prevention and treatment of rickets, osteoporosis, regulates myocardial function, blood clotting and nervous excitation.

This is a kind of replacement for sunlight, which is not enough just in the autumn-winter period.

2. How to take

The method of application is very convenient, it is used orally, before dissolving in a small amount of water.

Usually when prescribing a drug the pediatrician tells how to give aquadetrim to your child. Most often prescribed for 1 drop once a day, this is 500 IU of the vitamin. If babies born on time are prescribed medicine after one month, then for premature babies, twins and those who are in poor living conditions, it is recommended to take the drug from 7-10 days of life. Their dosage has been increased 2-3 drops once every 24 hours.

For the treatment of rickets the dose naturally increases. Depending on the severity and tolerance of the active substances, the doctor may prescribe 4-10 drops within a month or a half. Rickets-like diseases are treated with an even stronger dosage - up to 60 drops per day. The duration of the course of treatment also varies up to one and a half months.

In any case, the drug, despite its apparent simplicity and harmlessness, is not recommended to be used alone and you must strictly follow the instructions!

3. Side effects

The child's body is defenseless to any intervention, so even such seemingly harmless substances can cause serious side effects.

How to determine that you went too far with the medicine and the child has too much vitamin D(hypervitaminosis)?

• decreased appetite;
• there was nausea, vomiting;
• constipation, diarrhea, polyuria;
• anxiety arose;
• he drinks a lot, renal colic;
• headache and muscle pain;
• impaired renal function;
• stupor, irritability, sudden change of mood;
• severe weight loss;
• increase in pressure;
• calcification of blood vessels, kidneys and lungs.

If such symptoms appear, stop taking the drug immediately.

4. Contraindications

There are a number of cases in which to take a vitamin forbidden.

Contraindications to taking aquadetrim are as follows:

• an excess of vitamin D in the body and calcium;
• the presence of urolithiasis;
• sarcaidosis (systemic inflammatory disease);
• acute and chronic kidney disease;
• pulmonary tuberculosis;
• up to a month old.

Aquadetrim - an agent that regulates the exchange of calcium and phosphorus.

Pharmacological properties

The active substance of the drug Aquadetrim- cholecalciferol (vitamin D3) - a regulator of calcium and phosphate metabolism. Synthetic colcalciferol is identical to the endogenous one, which is formed in the body under the influence of sunlight. Colecalciferol has a more pronounced physiological activity in comparison with ergocalciferol (vitamin D2). Under the action of the drug, the metabolism of calcium and phosphates in the human body is normalized. This contributes to the proper formation of the bone skeleton and the preservation of the structure of bone tissue. The drug has a pronounced antirachitic effect. Colecalciferol promotes more intensive adsorption of calcium and phosphates in the distal small intestine, by increasing the permeability of cellular and mitochondrial membranes of the intestinal epithelium. Promotes the passage through the membranes of divalent ions, including calcium. Improves phosphate reabsorption during glomerular filtration. Facilitates the capture of calcium and phosphate by bone tissue, regulates the distribution of these ions in blood plasma, soft tissues and bones.

In addition, without cholecalciferol, the full functioning of the parathyroid glands is impossible. Influencing the production of lymphokines, the drug is involved in the formation of nonspecific immunity. Colecalciferol is involved in the synthesis of adenosine triphosphoric acid.

Normalization of the content of calcium ions in the blood leads to the maintenance of normal skeletal muscle tone, regulates the function of the heart. Vitamin D3 facilitates the conduction of nerve impulses, affects blood clotting.

With hypovitaminosis D and calcium deficiency, diseases such as rickets, osteoporosis can develop. They are especially susceptible to young children during a period of intensive growth and women in the postmenopausal period, due to hormonal changes in the body. In pregnant women with a lack of colecalciferol, symptoms of tetany occur.

Aquadetrim, an aqueous solution of cholecalciferol, is better adsorbed than oil solutions and has greater bioavailability. In addition, the aqueous solution does not require the presence of bile for absorption into the blood, which is an important factor for premature babies with an immature digestive system.

Adsorbed in the distal small intestine, metabolized in the liver and kidneys, excreted by the kidneys and partly with bile. After the release of cholecalciferol with bile, it can be re-adsorbed by the intestines, or excreted in the feces. Able to accumulate in the body. The drug penetrates well through the placental barrier, excreted in breast milk.

The half-life is 3-5 days and increases with insufficient renal function.

Indications for use

• Hypo- and avitaminosis D.
• Prevention and treatment of rickets and rickets-like diseases.
• Osteopathies caused by metabolic disorders, including hypoparathyroidism and pseudohypoparathyroidism.
• Hypocalcemia.
• Tetany caused by hypocalcemia.
• Osteomalacia of various etiologies.
• To accelerate the fusion and recovery of bones after fractures.
• Loss of calcium in bones and teeth.
• Osteoporosis, including those associated with hormonal changes during menopause and postmenopause.
• Spasmophilia.

Mode of application

The drug is taken orally, dissolved in a small amount of liquid (usually a dose of the drug is dissolved in a tablespoon of water).

1 drop of the drug contains about 500 IU of colecalciferol.

Doses are selected by the attending physician individually for each patient, taking into account many factors, including the amount of cholecalciferol that enters the body with food.

Average doses Aquadetrima are:

• Children born after 37 weeks of gestation, starting from 4 weeks of age, are prescribed 500 IU per day.
• Children born before 37 weeks of gestation, twins, children living in adverse conditions are prescribed 1000-1500 IU (2-3 drops) per day, starting from 3-4 weeks of life. In the summer, with sufficient exposure to fresh air, the dose can be reduced to 500 IU per day.
• Pregnant women, starting from the 28th week of pregnancy, are prescribed 500 IU per day.
• During menopause and postmenopause, 500-1000 IU per day is prescribed.

Taking the drug for the purpose of therapy:

In the treatment of rickets, the daily dose is 2000-5000 IU, while at first 2000 IU is prescribed for 5 days, if the drug is well tolerated, the dose is increased to the required therapeutic dose.

Colecalciferol at a dose of 5000 IU per day is prescribed only if the patient has severe bone pathologies. The course of treatment is up to 6 weeks, if necessary, the course is repeated after 1-2 weeks until a stable therapeutic effect is achieved, after which a maintenance dose of 500 IU per day is taken.

Aquadetrim in the complex therapy of osteoporosis in the postmenstrual period is used in a daily dose of 500-1000 IU.

Side effects

From the side of the central nervous system: headache, mental disorders, depression, stupor, mood swings, irritability.

From the gastrointestinal tract: nausea, vomiting, stool disorders, weight loss, anorexia, thirst, dry mouth.

From the side of the cardiovascular system: disorders of the heart, in particular arrhythmias, increased heart rate, increased blood pressure.

From the urinary system: polyuria, the formation of kidney stones, nephropathy.

From the musculoskeletal system: myalgia, arthralgia, general muscle weakness.

Others: exacerbation of the course of pulmonary tuberculosis, soft tissue calcification.

The frequency and severity of side effects increase with the course of taking the drug, due to its accumulation in the body.

Contraindications

Increased individual sensitivity to cholecalciferol, including history. Individual intolerance to benzyl alcohol.

Elevated calcium levels in the blood (hypercalcemia).

Elevated levels of calcium in the urine (hypercalciuria).

Hypervitaminosis D.

Urolithiasis with deposition of calcium oxalate.

Insufficiency of kidney function.

Active form of pulmonary tuberculosis.

Large doses of the drug are contraindicated for prolonged immobilization.

The drug is prescribed with caution during pregnancy and lactation.

In patients with atherosclerosis, sarcoidosis, hyperphosphatemia, acute and chronic diseases of the kidneys and liver. With violations of the gastrointestinal tract, in particular with gastric and duodenal ulcers. With organic lesions of the heart, such as pericarditis, myocarditis, etc.

Pregnancy

The use of the drug is possible after consultation with your doctor. Pregnant women are not prescribed the drug in high doses, as this can lead to impaired fetal development. The teratogenic effect of Akvadetrim may occur with an overdose of the drug. When a pregnant woman takes high doses, the fetus has an increased sensitivity to vitamin D, depression of the parathyroid gland, a syndrome of a specific elf-like appearance, aortic stenosis, and mental retardation. It is not recommended to take the drug in a dose exceeding 500 IU per day.

During the period of breastfeeding, it is necessary to take the drug with caution, since when the mother takes a large dose of Aquadetrim, symptoms of hypercalcemia in the child are possible.

Interaction with other drugs

Simultaneous use with antiepileptic drugs, neomycin, rifampicin, liquid paraffin, cholestyramine reduces the reabsorption of Aquadetrim.

Thiazide diuretics increase the risk of hypercalcemia and side effects of cholecalciferol.

The drug is able to enhance the toxic effects of cardiac glycosides, increases the likelihood of complications from the cardiovascular system.

Tocopherol, vitamin A, pantothenic acid, ascorbic acid, riboflavin reduce the risk of side effects of Aquadetrim, reduce its toxicity.

The break between taking Aquadetrim and sodium fluoride should be at least 2 hours. Between taking Aquadetrim and oral tetracyclines - at least 3 hours.

Concomitant use with vitamin D analogues increases the risk of hypercalcemia.

Barbiturates, when taken simultaneously with cholecalciferol, increase the rate of its biotransformation, which can lead to an increase in the need for cholecalciferol.

Overdose

When taking the recommended doses of the drug, an overdose is unlikely and is possible only in individuals with increased individual sensitivity to cholecalciferol. Overdose is manifested by symptoms characteristic of hypercalcemia - arrhythmias, nausea, vomiting, epigastric pain, headache, mood swings, weight loss, kidney stones, frequent urination, thirst, nephrocalcinosis and soft tissue calcification. Arterial hypertension, renal failure, stool disorders, anorexia.

If the drug is taken for too long or regularly taken in high doses, chronic cholecalciferol poisoning may develop, which is characterized by bone demineralization, instead of calcium deposits in soft tissues, including the kidneys, lungs, heart, blood vessels, and intestines. As a result of such mineral redistribution, organ functions are disrupted, which can lead to severe dysfunction of internal organs and, as a result, to death.

For the treatment of overdose conditions, corticosteroids, magnesium, potassium, retinol, thiamine, ascorbic acid preparations are used. It is also necessary to stop taking the drug Akvadetrim.

Release form

Solution for oral administration of 10 ml in dark glass bottles, 1 bottle in a carton.

Storage conditions

Shelf life - 3 years.

Synonyms

Vigantol, Vitrum osteomag.

Compound

1 ml of oral solution (30 drops) contains:

Colecalciferol - 15000 IU;

Excipients, including sucrose and benzyl alcohol.

main parameters

Today, it would seem, we have almost forgotten about such a terrible disease as rickets. Humanity has been overwhelmed by cardiovascular and immune pathologies, and diabetes mellitus is called the “plague of the century”. Nevertheless, on the shelves of almost all pharmacy kiosks, you can find Aquadetrim. Why, with a decline in obvious manifestations of hypovitaminosis of cholecalciferol, this drug does not lose its relevance?

The functions of vitamin D3 are directly related to the regulation of phosphorus-calcium metabolism in the body. That is why all the pathologies caused by a lack of this vitamin lead to diseases of the muscular, cardiovascular, bone and endocrine systems of a person.

Deficiency in the body is directly related to hypovitaminosis vit. D3. Especially often this relationship is manifested in the softening and senile degeneration of bone tissue.

And also in people with low consumption of dairy products, nuts, sea fish and seasonal restriction in greenery. Vitamin-mineral imbalance has also been identified in the following cases:

• Osteoporosis, as well as age-related changes in bone mineral density.
• Violation of the functions of the parathyroid glands.
• Pathologies of the immune system.

The use of therapeutic doses of calcium-containing drugs provokes high mortality from cardiovascular diseases.

It was found that the daily norm of calcium, which is 1000 - 1500 mg, requires a mandatory combination with cholecalciferol in the amount of 800 IU per day.

The lack of vit. D3 also accompanies somatic diseases:

• Chronic hypertension and cardiovascular pathologies.
• Diabetes mellitus type II.
• Chronic gastritis, peptic ulcer of the stomach and intestines, as well as other pathologies of the gastrointestinal tract. A history of cholecystitis increases the risk factor for hypovitaminosis.
• Pulmonary obstruction, tuberculosis.

With a lack of vit. D3 leads to tetanic muscle spasms and premature births. Provokes a violation of the formation of bone tissues of the fetus.

Composition and form of release Akvadetrim

Vit. D3 is unstable to UV radiation and is easily destroyed when exposed to air. Therefore, a dark glass bottle containing 10 ml of an aqueous solution of calciferol is equipped with a dosing pipette and a cap. This not only facilitates the dosage of the drug, but also protects it from oxidation.

From the point of view of compensating for the lack of cholecalciferol, dietary supplements containing at least 400 IU of the active substance have a vitamin value. 1 ml of a solution equivalent to 30 drops contains:

1. Vit. D3 - 15000 IU, 500 IU in 1 drop.
2. Excipients contribute to the stabilization of cholecalciferol and provide the possibility of its long-term storage. They also improve the taste and aroma properties of the drug. In addition, citric acid in bone tissue forms with calcium under the action of vit. D3 insoluble salts that promote bone mineralization.

• Macrogol glyceryl ricinoleate is a substance whose main component is castor oil.
• Citric acid - flavor and preservative E330, benzyl alcohol - flavor and preservative, sucrose - flavor and stabilizer, sodium hydrogen phosphate dodecahydrate - preservative E 339.
• Flavoring - anise essence.
• Purified water.

Indications for taking Akvadetrim

Necessary for activation of macrophage immune responses. Especially with mycosporic lesions of the lungs. Including tuberculosis and chronic obstruction.

To reduce the hyperfunction of the parathyroid glands.

Acquired hypovitaminosis D3 associated with malnutrition, rare exposure to the sun or peculiarities of national dress. Often leads to thyroid adenoma. It is also observed in liver diseases and lipid metabolism disorders such as celiac disease and cholestasis.

Prevention of rickets in children from 2 months to 2 years. The manifestations of this formidable disease are: softening of the bones, deformation of the skull, chest and legs, an increase in the abdomen, muscle flabbiness, slowing down the ossification of the fontanel and an increase in the period of teething. For (and for older children) it is better to use an aqueous solution of vitamin Aquadetrim, as it is absorbed faster and better absorbed by the body than oil drops.

Dosage

With a daily requirement for vit. D3 in children - from 500 to 1000 IU and adults - 800 IU, Aquadetrim is recommended both prophylactically and for the correction of calcium phosphorus metabolism disorders:

Children from 4 weeks to 3 years prophylactically - 1 drop. If there is a risk of developing rickets - from 2 to 3 drops.

1 drop per day. With special instructions from the doctor - 2 drops from 28 weeks.

Postmenopausal period -1 or 2 drops.

Treatment of rickets and rickets-like conditions is carried out only under the supervision of the attending physician and depends on the severity of the disease.

Therapy vit. D3 is individual for each patient and requires biochemical control throughout the treatment.

Contraindications

Hypervitaminosis vit.D.

High levels of calcium in the blood and urine.

Violation of water-salt metabolism, including with a tendency to form calcareous kidney stones.

Chronic renal failure and other disorders of the kidneys or liver.

Sarcoidosis and tuberculosis in the acute phase.

Intolerance to food additives of class "E".

Newborns up to 4 weeks.

Without special instructions from the doctor, you should refrain from taking Aquadetrim when:

Tendency to allergies.

Combination with diuretic thiazides.

Simultaneous reception with glycosides increases the toxicity of digitalis and the risk of cardiac arrhythmias.

Dangers of hypervitaminosis D3 during pregnancy and lactation.

The propensity of newborns to the rapid overgrowth of the fontanel.

Side effects

Overdose. Vitamin D3 is easily absorbed, entering the body as part of fatty milk products (cream, sour cream,), as well as egg yolks, and yeast. In addition to this, it is formed in the skin under the action of sunlight and accumulates. Therefore, uncontrolled intake of Aquadetrim can lead to hyperavitaminosis of cholecalciferol.

Symptoms: nausea, vomiting, loss of appetite and weight, thirst, increased daily diuresis and the appearance of protein in the urine, constipation, hypertension, excessive muscle tone and joint pain. From the side of the National Assembly: headache, mental disorder, depression, insomnia.

Chronic overdose makes the bones brittle and brittle. Vessels, tissues and lungs lose their softness and elasticity during the formation of lime deposits. Ataxia, stupor, inflammatory keratids, cataracts, papilledema, and urolithiasis are possible.

Interaction with other drugs

Suppressed by phosphates and calcium.

Decreased effectiveness when taken simultaneously with cholestyramine, antiepileptic drugs and rifampicin.

Combination with digitalis preparations and thiosides is life threatening.

Aquadetrim is equivalent to dietary supplements. It is believed that such funds do not require the advice of specialists. However, numerous nuances of Aquadetrim's effect on the body urgently require a doctor's consultation.

The average price for vitamin D3 aquadetrim in Moscow pharmacies is about 195 rubles. But, in online pharmacies you can find cheaper (from 125 rubles).

Reviews about Akvadetrim

Pavel S. The summer turned out to be rainy, and my daughter is at the age when children grow up. Heard enough of the doctor's warnings about rickets and decided to insure himself with Aquadetrim. It wouldn't hurt to do it myself either. Before meeting with Akvadetrim, he considered all side effects to be empty talk. To be honest, I didn't even look at the abstract. They said that the vitamin is good, period. Daughter sprinkled immediately, and me - a week later. I sinned on fruits, shampoo and powder, but it turned out that the damned drug was to blame. The auxiliary composition is such that it is easier to drink the solvent. And this is what doctors prescribe for children! The Poles don't care what they sell us, but children are not a field for experimentation.

Tatiana B. 24 The reason for the appointment of Akvadetrim to my daughter is rickets 2 of the subacute course, the peak period. For a number of reasons, the child was born severely premature. Instructions for the use of vitamin D3 Aquadetrim and reviews on the Internet terrified me. But is allergy so terrible compared to rickets? Moreover, the oil-based vitamin was not suitable for us due to problems with the intestines. I can understand parents canceling Aquadetrim because of the backlash. Their children were prescribed the drug for prophylactic purposes. For us, he was a real lifesaver.

Kuzmin S.E., Dr. med. Sciences. The pathophysiological significance of hypovitaminosis of cholecalciferol in the anamnesis of somatic and cardiovascular diseases is enormous. The use in clinical practice of combination therapy of calcium-containing drugs with Aquadetrim in a daily dose of at least 800 IU recorded a positive trend. I would also like to note the preventive role of Akvadetrim in case of the threat of osteoporotic fractures and other disorders of bone tissue mineralization.

Smirnova E. N., pediatrician. Rickets in children does not pose an immediate threat to life, but increases mortality from concomitant diseases. It is rickets who are difficult to tolerate pneumonia, measles and whooping cough. Often hypovitaminosis D3 leads to the development of anemia, pneumonia, pathologies of the liver and spleen.

Newborns receive the necessary substances with mother's milk. Seasonal solar activity plays a huge role in this. Therefore, the risk group is made up of artificial children and children born in the autumn-winter season.

Rickets is a disease of rapid growth.

The needs of a growing organism for phosphorus, calcium and cholecalciferol are not satisfied by their delivery system.

Aquadetrim showed excellent results in the prevention and treatment of rickets. Its use allows you to normalize the functions of both a number of systems and organs, and the whole organism as a whole. After all, despite the strong opinion about the predominance of musculoskeletal symptoms of rickets, its first manifestations are associated with the nervous system. Anxiety, tearfulness, the appearance of diaper rash due to excessive sweating can be a signal for the appointment of Akvadetrim. At the same time, it is important to prevent the outbreak of the disease.

Features of the metabolism of cholecalciferol and its close relationship with mineral metabolism make Aquadetrim a therapeutic drug rather than a dietary supplement. Too huge connection vit. D3 with the nervous, endocrine, muscular and cardiovascular systems of the body.

In general, Aquadetrim is an excellent prophylactic and therapeutic agent in the presence of factors that reduce the effectiveness of oil solutions of vit. D3.

The allergenic composition of Aquadetrim excipients is associated with the fat-soluble nature of its active ingredient. It is worth noting that chem. class E substances are officially used not only in pharmacology. Most modern products are “rich” in more serious additives, but they do not cause complaints from consumers.