Concor: indications and contraindications. Concor instructions for use, contraindications, side effects, reviews Concor side
Diseases of the cardiovascular system, of course, need to be treated. The main medicinal purpose is antihypertensive beta-blockers, but like other medicines, they have contraindications and side effects.
If taken for long courses, they can cause a strong blow to the viability of the reproductive system, overwhelmingly affect the synthesis of testosterone, as the main male hormone. But how does concor behave, does it have side effects for men? Can they lead to a decrease in potency, because the annotation does not say how this drug negatively affects erectile function?
Concor, what kind of medicine?
Concor is a beta-blocker, it contains bisoprolol as an active ingredient. Indications for use:
Active drug
- ischemia of the heart;
- myocardial infarction (secondary);
- arrhythmia;
- tachycardia;
- hypertension;
- heart failure;
- angina.
This is a new generation cardio drug with a small number of side effects, unlike other old analogues. Concor has an antianginal effect, helps to reduce heart rate, supply oxygen to the heart muscle, normalize blood pressure, increase vascular elasticity, and compensate for heart failure. As a result, to the normalization of pressure indicators, the elimination of tachycardia attacks.
If you neglect the doses, then side effects can be taken by surprise:
Weakness and dizziness - weakness;
- numbness of hands, feet;
- headache;
- nausea, vomiting;
- a sharp decrease in vision;
- increased sweating;
- slow heart rate;
- dysfunction of the gastrointestinal tract.
The main contraindications for use:
- heart failure;
- low pressure;
- bronchial asthma.
REFERENCE! Drowsiness and headache are the main side effects after taking Concor. It is undesirable to take the drug if you are concerned about depression, which can also be triggered during treatment. It is better to choose more gentle analogues, consult a specialist. For example, Nebivolol has a similar effect, but does not lead to similar adverse reactions, does not adversely affect erection, reproductive functions of men
Side effects
Concor belongs to the group of strong beta-blockers of the new generation. It is designed to reduce pressure, but at the same time it can lead to the development of erectile dysfunction, other complications, side effects and effects.
When using the drug, a direct effect is exerted on the nervous system, which in turn can provoke unpleasant symptoms:
Fatigue and sleepiness - distortion of color perception;
- drowsiness;
- dizziness;
- fear for no reason;
- chronic fatigue;
- headache;
- excessive feeling of anxiety;
- nightmares;
- chronic fatigue.
The constant manifestations of such symptoms are not reflected in the best way on the psycho-emotional background of men, in particular the reproductive system, eventually leading to impotence, erectile dysfunction. So if at an early stage there is no ejaculation, and ejaculation comes 2-3 hours late at the time of intimacy after excitability, then over time the disease will begin to progress and erection problems may become apparent.
On a note? If there are constant depressions, a tendency to suicide while taking Concor, then it is better to refuse and look for gentle analogues with a different chemical composition. If there are signs of an overdose and a toxic effect, then you need to urgently rinse the stomach, drink an activated charcoal tablet, visit a therapist, a urologist
How does the drug affect potency
It can be assumed that this medication will not have a negative effect on potency, since it is recommended for use even by older men with diabetes. But, the opinion of doctors and patients is ambiguous. It's all about arterial hypertension, the impact of which falls on the organs of the genitourinary system - the kidneys, blood vessels, heart. If the vessels begin to suffer, then the reproductive system will experience a lack of nutrients, and the prostate will lack oxygen when supplied to the tissues. If heart problems appear, then the physical condition and endurance of men will be greatly undermined.
The kidneys, as the main urinary organ, in the event of a malfunction, will lead to a water-salt imbalance, and these are problems with urination:
Poor urine output - departure of a sluggish stream.
- urinary retention.
- pain, pain, burning.
- incontinence at first.
Erectile function begins to gradually decline. In addition, antihypertensive drugs have a depressing effect on testosterone synthesis. In the male body, the concentration of, on the contrary, the female hormone, estradiol, begins to increase. It is unlikely that with such an imbalance in the hormonal background, one can speak of a normal, timely erection.
Is it worth looking for a replacement for concor?
A cardiac beta-blocker does not have the best effect on the sexual sphere of men, but has proven its effectiveness in the treatment of vascular and heart diseases. It can become indispensable for patients with diabetes mellitus.
If we compare concor and side effects for men with other analogues, then the number of unpleasant manifestations is minimal.
Use as directed by a doctor in compliance with dosages will prevent the development of complications, severe defects:
- bronchospasm;
- heart failure;
- a sharp decrease in blood pressure;
- bradycardia;
- myocardial infarction.
According to doctors? It is not Concor itself that has a negative effect on potency, namely hypertension, which leads to dysfunction of the heart muscle, deterioration of blood flow. So it begins to have a negative impact on potency. Men develop sexual impotence. Needless to say that a healthy erection is possible only with a normal outflow of blood, tides to the cavernous bodies of the penis.
Hypertension, like high blood pressure, is the enemy of men's health. Fear and fear of getting sexual disorders provoke only additional psycho-emotional instability in the stronger sex. It is men after 50 years of age who often experience a complete list of problems in the genital area and many unpleasant manifestations.
In the course of clinical studies, it was found that there is no negative effect of concor on potency. The drug did not have the best effect on intimate life in only 5% of men in old age, and in those who experienced erectile dysfunction before using Concor. If we talk about the younger generation, then Bisoprolol as an active ingredient can adversely affect potency in isolated cases. This component is harmless, low-toxic.
If hypertension is not treated, then impotence will develop much faster than from taking Concor's medication. The instruction indicates that the drug reduces libido and potency, although the overwhelming effect on the reproductive system from high pressure can be much stronger.
How to increase potency and stabilize blood pressure
Products for potency For young guys, of course, potency is more important than blood pressure jumps. But if you completely stop taking adreno-blockers prescribed by your doctor, then high blood pressure is fraught with complications - stroke, myocardial infarction. Diseases are clearly life threatening. However, it is still possible to minimize the negative impact on potency in men, the genitourinary system. After all, no one canceled simple preventive measures, lifestyle.
It:
- Dieting, refusal of products that provoke an increase in pressure. Only proper nutrition will prevent an increase in pressure, reduce the dosage of medications taken.
- Elimination of bad habits (alcohol, smoking), because you can reduce the dose of Concor if you refuse to drink alcohol in excess of the norm, while the pressure will not jump to high values.
- Maintaining an active lifestyle, tk. it is congestion in the pelvic area that provokes a violation of urination, at the same time - a deterioration in erection.
REFERENCE! Alcohol and tobacco lead to poisoning of the body at the cellular level. The deposits of nicotine in the body reduce the elasticity and permeability of the vascular walls, impair blood supply, provoke insufficient blood flow to the cavernous bodies. The heart, blood vessels, kidneys, potency begin to suffer. Alcohol contributes to a decrease in sperm motility, a deterioration in the quality of sperm. Endogenous testosterone gradually reduces its production, fertilization and conception for men becomes problematic
Negatively influencing bad habits lead to the development of prostatitis and this is also the enemy of male ability. If the disease is not treated in time, then it is possible to live up to oncology, when there can be no question of viability in sex. If tobacco can be attributed to a rather weak, harmless drug, then abuse, for example, marijuana, can lead to chromosome damage and genetic mutations in men. And this is despite the fact that this herb is of plant origin.
Doctors have a special attitude towards steroids. The effect of the application is the acceleration of protein synthesis and increased endurance, which is important for athletes. But a long, illiterate intake of these drugs is fraught with the development of erectile dysfunction, a sharp decrease in testosterone production.
If you still reconsider your lifestyle, start actively playing sports and walking more. Physical activity is conducive to increasing potency, activates blood flow, and normalizes metabolic processes. If there is a tendency to depression, then it will not be superfluous for men to undergo a course of psychotherapy, reconsider their behavior and outlook on life.
As for Concor, one of the side effects is excessive anxiety, an obsessive feeling of fear. Men tend to sleep, but the fear of seeing nightmares leads to depression, erectile disorders. The emotional sphere and potency in men are inextricably linked. If there is a tendency to suicidal acts, then of course, you should consult a doctor. It is better to stop taking Concor and choose another optimal drug. Although it is quite effective in the treatment of cardiac pathologies, the new drug, unlike other analogues of the old generation, has more side effects.
The main thing is to take Concor, according to the instructions, do not neglect the dosages and instructions of the doctors.
Concor: instructions for use and reviews
Concor is a selective beta 1-blocker.
Release form and composition
Dosage form of Concor - film-coated tablets: light yellow or light orange in color, have a biconvex heart-shaped shape and a separating risk on both sides (5 mg or 10 mg in blisters: 10 pcs., in cardboard packs 3 or 5 blisters; 25 pcs., in cardboard packs 2 blisters; 30 pcs., 1 blister in a carton pack; 5 mg, 30 pcs. in a blister, 3 blisters in a carton box).
Active ingredient - bisoprolol hemifumarate (bisoprolol fumarate (2:1)):
- 1 light yellow tablet - 5 mg;
- 1 light orange tablet - 10 mg.
Auxiliary components: corn starch, anhydrous calcium hydrogen phosphate, anhydrous colloidal silicon dioxide, crospovidone, microcrystalline cellulose, magnesium stearate.
The composition of the film shell: titanium dioxide (E171), hypromellose 2910/15, dimethicone 100, macrogol 400, iron dye yellow oxide (E172).
Additionally, in the composition of the film shell of light orange color - iron dye red oxide (E172).
Pharmacological properties
Pharmacodynamics
Concor is a selective beta 1-blocker that does not have its own sympathomimetic activity and membrane stabilizing effect. It has a slight affinity for beta 2 -adrenergic receptors of the smooth muscles of blood vessels, bronchi and for beta 2 -adrenergic receptors, which are involved in the regulation of metabolism. The drug does not affect the resistance of the respiratory tract, as well as metabolic processes that occur with the participation of beta 2-adrenergic receptors.
The selective effect of bisoprolol on beta 2 -adrenergic receptors is also observed outside the therapeutic range.
Bisoprolol does not have a pronounced negative inotropic effect. After oral administration, the maximum effect is achieved after 3-4 hours. The half-life is 10-12 hours. When using the drug once a day, the therapeutic effect persists for 24 hours. Most often, the maximum decrease in blood pressure is achieved 2 weeks after the start of therapy.
Bisoprolol blocks beta 2-adrenergic receptors of the heart and reduces the activity of the sympathoadrenal system.
In coronary heart disease and in the absence of chronic heart failure, a single oral dose of bisoprolol reduces heart rate and stroke volume, which leads to a decrease in ejection fraction and a decrease in myocardial oxygen demand.
With long-term treatment, there is a decrease in the initially increased total peripheral vascular resistance, and the activity of renin in the blood plasma also decreases (this effect is considered one of the components of the hypotensive effect of beta-blockers).
Pharmacokinetics
- absorption: bisoprolol is absorbed from the gastrointestinal tract almost completely (over 90%). Bioavailability when taken orally is about 90%, there is a slight effect of "first pass" through the liver, in which about 10% is metabolized. Food intake does not affect bioavailability. The drug demonstrates linear kinetics, its concentration in blood plasma is proportional to the accepted dose of bisoprolol in the range of 5-20 mg. The time to reach maximum plasma concentration is about 2-3 hours;
- distribution: bisoprolol is distributed quite widely. The volume of distribution is 3.5 l / kg, the connection with plasma proteins is about 30%;
- metabolism: bisoprolol is metabolized by the oxidative pathway without conjugation. Metabolites of bisoprolol are polar (water-soluble), excreted by the kidneys. The main metabolites found in urine and blood plasma lack pharmacological activity. The results of studies of human liver microsomes showed that in vitro bisoprolol is primarily metabolized using the CYP3A4 isoenzyme (approximately 95%), and the role of the CYP2D6 isoenzyme is insignificant;
- excretion: the clearance of bisoprolol is due to the balance between excretion unchanged by the kidneys (about half the dose) and its metabolism in the liver (about half the dose) to metabolites excreted by the kidneys. The total clearance is 15 l / h, the half-life is 10-12 hours.
There are no data on the pharmacokinetics of Concor in patients with impaired renal or hepatic function and simultaneous coronary heart disease.
Indications for use
- Chronic heart failure;
- Arterial hypertension;
- Stable angina in ischemic heart disease.
Contraindications
- Acute form of heart failure;
- Decompensated chronic heart failure;
- Cardiogenic shock;
- Atrioventricular (AV) block II and III degree (in the absence of a pacemaker);
- Sick sinus syndrome;
- Severe bradycardia (heart rate (HR) less than 60 beats per minute);
- A pronounced decrease in blood pressure (BP) (systolic blood pressure below 100 mm Hg);
- Sinoatrial blockade;
- Severe form of bronchial asthma and chronic obstructive pulmonary disease (COPD), indicated in the anamnesis;
- Raynaud's disease, severe disorders of the peripheral arterial circulation;
- metabolic acidosis;
- Pheochromocytoma (without combination with alpha-blockers);
- Age up to 18 years;
- The period of breastfeeding;
- Hypersensitivity to the components of the drug.
Concor should be administered with caution to patients with severe hepatic impairment, Prinzmetal's angina, type 1 diabetes mellitus and diabetes mellitus with significant fluctuations in blood glucose, hyperthyroidism, AV block I degree, psoriasis, severe renal failure (creatinine clearance less than 20 ml / min), congenital heart disease or valvular heart disease with severe hemodynamic disorders, restrictive cardiomyopathy, chronic heart failure due to myocardial infarction within the next 3 months, during the period of desensitizing therapy, as well as patients on a strict diet.
The use of Concor during pregnancy is possible if, according to the doctor's determination, the intended therapeutic effect for the mother outweighs the potential risk to the fetus (bisoprolol hemifumarate reduces blood flow in the placenta).
Instructions for use Concor: method and dosage
Concor tablets are taken orally, without chewing, with a sufficient amount of liquid. The drug should be taken once a day, in the morning, regardless of the meal.
The doctor prescribes dosing individually, taking into account the patient's condition and clinical indications.
In the treatment of angina pectoris and arterial hypertension, the dose is selected, taking into account the patient's heart rate. You should start with 5 mg per day. If necessary, the dose can be increased to 10 mg, it is not recommended to exceed 20 mg.
Treatment of chronic heart failure is carried out according to the standard scheme, including combination therapy, which includes angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor antagonists (with intolerance to ACE inhibitors), diuretics, beta-blockers, cardiac glycosides.
Concor is indicated only for stable chronic heart failure without exacerbation symptoms. Special titration phases must be carried out according to a specific scheme.
The recommended initial dosage in the treatment of chronic heart failure is 1.25 mg. Further dose adjustment depends on the individual tolerance of bisoprolol and is carried out after a certain adaptation to the previous one.
The dose is increased gradually, 1 time in 2 weeks by 1.25 mg, the maximum dose is 10 mg. The selection of the dose of Concor is carried out under the supervision of a physician and the control of heart rate, blood pressure, in case of an exacerbation of the condition against the background of the last titration, the dose should be reduced to the previous one.
A temporary exacerbation of the symptoms of the course of the disease, the appearance of arterial hypotension or bradycardia is possible from the first days of using the drug, during titration and treatment. In this case, it is necessary to simultaneously adjust the doses of concomitant therapy and bisoprolol, and in critical situations, cancel it until the patient's condition stabilizes. Then you can continue treatment or start re-titration of the dose.
The use of Concor for all indications is long-term.
Patients with mild or moderate hepatic or renal dysfunction and elderly patients do not usually need a dosage adjustment.
In case of severe impairment of kidney and liver function, the recommended daily dose should not exceed 10 mg, and increasing the dose in this category of patients is carried out with extreme caution.
Side effects
Against the background of the use of Concor, the following side effects may occur:
- From the side of the cardiovascular system: very often - bradycardia (with chronic heart failure); often - exacerbation of symptoms of chronic heart failure (with chronic heart failure), a feeling of numbness or coldness in the extremities, a strong decrease in blood pressure (more often in patients with chronic heart failure); infrequently - bradycardia (with angina pectoris or arterial hypertension), impaired AV conduction, orthostatic hypotension, increased signs of chronic heart failure (with angina pectoris or arterial hypertension);
- From the digestive system: often - vomiting, nausea, diarrhea or constipation; rarely - hepatitis;
- From the nervous system: often - dizziness and headache (more often at the beginning of treatment of arterial hypertension or angina pectoris, is mild and disappears after 1-2 weeks of therapy); rarely - loss of consciousness;
- From the senses: rarely - hearing impairment, decreased tearing; very rarely - conjunctivitis;
- On the part of the psyche: infrequently - insomnia, depression; rarely - terrible dreams, hallucinations;
- From the reproductive system: rarely - potency disorders;
- On the part of the respiratory system: infrequently - bronchospasm against the background of bronchial asthma or obstructive respiratory diseases in history;
- From the musculoskeletal system: infrequently - muscle cramps, muscle weakness;
- On the part of the skin: very rarely - alopecia; in patients with psoriasis - exacerbation of the disease or the appearance of a psoriasis-like rash;
- Allergic reactions: rarely - itching, skin rash, hyperemia, allergic rhinitis;
- On the part of laboratory parameters: rarely - an increase in the blood level of the concentration of liver enzymes (alanine aminotransferase and aspartate aminotransferase);
- Others: often - asthenia (with chronic heart failure), increased fatigue (more often at the beginning of treatment of arterial hypertension or angina pectoris, is mild and disappears after 1-2 weeks of therapy); infrequently - asthenia (with arterial hypertension or angina pectoris).
Overdose
The most common symptoms: AV blockade, marked decrease in blood pressure, severe bradycardia, acute heart failure, hypoglycemia, bronchospasm.
With a single high dose of bisoprolol, sensitivity in individual patients varies greatly. Probably, for patients with chronic heart failure, the sensitivity is increased.
In case of overdose, stop taking Concora and resort to supportive symptomatic therapy.
With severe bradycardia, intravenous atropine is recommended. If these measures are not enough, you can carefully enter the drug with a positive chronotropic effect. In some cases, temporary setting of an artificial pacemaker is carried out.
In the case of a pronounced decrease in blood pressure, intravenous administration of vasopressor drugs and plasma-substituting solutions is recommended.
With AV blockade, the patient should be constantly monitored and therapy with beta-adrenergic agonists (for example, epinephrine) should be prescribed. In some cases, temporary setting of an artificial pacemaker is appropriate.
In case of exacerbation of the course of chronic heart failure, intravenous administration of diuretics, vasodilators and agents with a positive inotropic effect is recommended.
For bronchospasm, bronchodilators are prescribed, including beta 2-agonists and / or aminophylline.
special instructions
You can not abruptly stop therapy, especially in patients with coronary heart disease, the abolition of Concor should take place by gradually reducing the dose. Dosing adjustments are made under the supervision and on the recommendation of a physician.
Patients with bronchial asthma or COPD are prescribed the drug only while taking bronchodilators. With an increase in airway resistance, it is recommended to increase the dose of beta 2-adrenergic agonists in patients with bronchial asthma.
Against the background of Concor, it is possible to increase sensitivity to allergens and the severity of anaphylactic reactions, while treatment with adrenaline (epinephrine) may not have a sufficient therapeutic effect.
Before a planned surgical operation using general anesthesia, it is necessary to gradually reduce the dose of the drug and stop taking it 48 hours before the start of the operation. The anesthesiologist should be informed about the intake of bisoprolol.
With pheochromocytoma, the use of the drug is possible only against the background of alpha-blockers.
The drug may mask the symptoms of hyperthyroidism.
Although Concor does not affect the patient's ability to drive vehicles and mechanisms, but given the varying individual tolerability of the drug and the possible violation of the condition when changing the dose, caution is recommended, especially at the beginning of treatment and in case of simultaneous use of alcohol.
Use during pregnancy and lactation
According to the instructions, Concor is allowed to be used during pregnancy only in cases where the potential risk to the fetus is lower than the expected benefit to the mother.
Under the action of beta-blockers, the blood flow in the placenta is reduced, which can affect the development of the fetus. Shows the control of blood flow in the uterus and placenta, as well as monitoring the development of the fetus. In case of diagnosis of adverse events, it is recommended to turn to alternative methods of treatment. The newborn after childbirth should be carefully examined. In the first three days of life, symptoms of hypoglycemia and bradycardia may appear.
There are no data on the excretion of bisoprolol into breast milk, so taking Concor during breastfeeding is not recommended. If the use of the drug is necessary, then breastfeeding should be discontinued.
Application in childhood
It is contraindicated to use Concor for the treatment of patients under the age of 18 years.
For impaired renal function
With severe renal failure (CC up to 20 ml / min), Concor should be used with caution. For mild to moderate renal impairment, there is no need to adjust the dose.
For impaired liver function
With severe violations of liver function, Concor should be used with caution. The maximum dose in such patients should not exceed 10 mg. For mild to moderate hepatic impairment, there is no need to adjust the dose.
Use in the elderly
In the treatment of elderly patients, dose adjustment is not required.
drug interaction
When prescribing Concor, the patient must inform the doctor about all the medicines that he is taking. This information will allow the doctor to take into account the possible interaction of drugs and give the patient the necessary recommendations about the rules and sequence of their use.
In the treatment of chronic heart failure, the simultaneous administration of quinidine, lidocaine, disopyramide, phenytoin, propafenone, flecainide and other class I antiarrhythmic drugs is not recommended.
Undesirable combinations for the simultaneous use of Concor:
- Diltiazem, verapamil and other slow calcium channel blockers can cause a decrease in myocardial contractility and impaired AV conduction;
- Clonidine, moxonidine, methyldopa, rilmenidine and other centrally acting antihypertensive drugs can cause a decrease in cardiac output and heart rate and lead to vasodilation against a background of a decrease in central sympathetic tone. The likelihood of rebound hypertension increases with abrupt discontinuation of the drug before the abolition of beta-blockers.
Special care should be taken in the treatment of angina pectoris and arterial hypertension in combination with lidocaine, quinidine, disopyramide, flecainide, phenytoin, propafenone (class I antiarrhythmic drugs), this combination with bisoprolol can reduce myocardial contractility and AV conduction.
Drugs in combination with which the appointment of Concor requires special care:
- Felodipine, nifedipine, amlodipine and other dihydropyridine derivatives - increase the risk of arterial hypotension, with chronic heart failure, a subsequent deterioration in the contractile function of the heart is possible;
- Non-steroidal anti-inflammatory drugs - reduce the hypotensive effect of bisoprolol;
- Amiodarone and other class III antiarrhythmic drugs - may exacerbate AV conduction disturbance;
- Beta-blockers for topical use, including eye drops for the treatment of glaucoma - increase the systemic effect of bisoprolol;
- Parasympathomimetics - may increase the risk of developing bradycardia and impaired AV conduction;
- Oral hypoglycemic agents and insulin - increase their clinical effect, symptoms of hypoglycemia (tachycardia) may be suppressed or masked;
- Preparations for general anesthesia - increase the likelihood of a cardiodepressive effect, which can lead to arterial hypotension;
- Cardiac glycosides - can increase the time of impulse conduction and lead to the development of bradycardia;
- Tricyclic antidepressants, phenothiazines, barbiturates and other drugs with an antihypertensive effect - may increase the hypotensive effect of Concor;
- Mefloquine - increases the likelihood of developing bradycardia;
- Monoamine oxidase (MAO) inhibitors (except for MAO B inhibitors) - potentiate the hypotensive effect of the drug and can cause the development of a hypertensive crisis.
The combination of Concor with isoprenaline, dobutamine and other beta-agonists leads to a decrease in the clinical effect of both drugs.
Simultaneous administration with bisoprolol of adrenomimetics that affect alpha and beta adrenoreceptors (norepinephrine, epinephrine) leads to an increase in blood pressure.
Analogues
The analogues of Concor are: Bisoprolol, Bisoprolol Sandoz, Bisoprolol-Richter, Bisoprolol-Maxpharma, Biprol, Bicard, Bisocard, Bisostad, Bisoprofar, Coronal, Cordinorm, Concor Cor, Coronal.
Terms and conditions of storage
Store at temperatures up to 30 °C. Keep away from children.
Shelf life - 5 years.
There can be many side effects of this drug. However, each system of the body reacts in its own way to its use.
Central nervous system:
- fatigue, dizziness, headaches, sleep disturbances, sometimes hallucinations.
Organs of vision:
- conjunctivitis, decreased tearing;
The cardiovascular system:
- rare, but bradycardia, orthostatic hypotension are possible.
Respiratory system:
- occasional shortness of breath.
Digestive system:
- sometimes side effects are manifested through diarrhea, constipation, nausea, abdominal pain.
reproductive system:
- Violation of potency.
Itching, redness of the skin, muscle weakness are also possible.
The concor also hurt me personally, from the beginning there was a strong breakdown, eternal drowsiness, I could not drive, some kind of absent-mindedness, nervousness, and the last reason I was finished off by a strong weakening of potency. I don’t drink anymore and I don’t advise you.
Please do not drink CONCOR, I was prescribed by a doctor when problems began, women will understand me. Discharged from a small dose, took 2 years. Teachard jumped. I went to bed, a doctor with 40 years of experience, a neurologist, said who prescribed this (rubbish) for you. I said the therapist. He says immediately go to your therapist so that he cancels you properly. I rushed over and quickly to her. I told her everything, as KONDRATEV said, in our city one is considered a very good doctor. She tells you that the concor is bad for you. I say no. I say listen to the Doctor, he has a dynasty of doctors and his wife is a doctor, he has more work experience than your age. She says it's your business to accept or not. The result, a year later, I began to cough and whistle in my chest, I was treated with folk remedies, nothing helped. I went to her, she listened and says you have a side effect from concor. I tell her, I told you, but you didn't listen. I, who did not know what it was to get sick with a respiratory tract, now I constantly pick up orvi. Hardened since childhood, now I’m looking for how to cure shortness of breath from concor.It's strange .... if you immediately had bronchospasm on Concor or you have problems with your lungs, then all blockers are contraindicated for you and it's not specifically about Concor.
Great help! Pulse 120 beats, terrible shortness of breath and pressure 150/110. They prescribed Prestans from pressure - it fell sharply from him, she began to take half in the morning before breakfast + Con-core. Feeling much better. This is the first time I've seen such bad reviews about Con-Kora.There was a high blood pressure of 160-100, the therapist prescribed Lorist N-100 2.5 mg + 100 and Concor 2.5 mg in the morning and cardiac Trimetazidin MB 1 ton in the morning-evening + Torvacard 10 mg in the evening. I took these pills for a month and the pressure returned to normal, chest pains in the iliac region stopped. True, the pressure sometimes dropped to 115-70 110-67, I went to the doctor and she advised me to take half of Concor and if this does not work, then half of Lorist H-100. In the future, the pressure does not dropped below 120 and did not rise above 137-80.
My pressure jumped, they prescribed CONCOR, I drank it only half a tablet, only in the morning for three days. As a result, the pressure dropped 90 to 60, the pulse was 60 beats, I suffered for two days, I could hardly breathe, and on the fourth day I got up in the morning, I feel that its action has ended and I am shaking like a pear, the pressure is normal, and the pulse is up to 100 beats. They are narcotic or something. The conclusion is that the pills are terrible, maybe they help someone, but they need to be prescribed with GREAT caution.
After the hospital (atrial fibrillation), I was also prescribed concor cor 1.25 in the morning. Shaking, everything falls out of hand, anxiety. It turns out that it is necessary to drink with antidepressants. Like this. Didn't take it.
I'm 52 years old. The cardiologist prescribed me Concor 5/5 for high blood pressure (190/100), before that I drank Valz 160/12.5 in the morning in the evening Physiotens 0.4. The first day seemed to be normal, but at night I couldn’t sleep - insomnia, the second day I started to shiver, my pulse dropped to 50 (working 72-75), I felt worse and worse. , then my blood pressure rose under 200 and my pulse became below 48, I called an ambulance, thanks to the ambulance doctors. I am writing for those who are going to take concor, be sure to start with small doses, otherwise an unpredictable medicine, DOCTORS DO NOT WARN ABOUT THIS!
Have you read the instructions? Did you go to a cardiologist?
The doctors are warning. And the instructions say that you need to start with a dosage of 2.5
Took the drug for 4 years! 10 mg sometimes 15 mg per day. I have hypertension, the first stage, the pressure is 160/100. It helped well for the first two years.. Then side effects began to appear.. I barely quit Concor!! Threw slowly reducing the dosage by 2.5 mg. every week. Even after I quit, I feel a slight discomfort in the heart area .. Now I take anaprilin 40 mg twice a day) it seems nothing) Guys, in general, the drug is very serious! Quitting is very hard! Think!! It’s better to find an analogue a little weaker, but it won’t be so hard to quit) now I take different heart medications every half a year) like nothing)
What glasses
Concor is not for everyone. Who suits and who doesn’t. The approach to each is individual. He has a lot of pitfalls. Dangerous drug!
People write correctly - let these unfortunate doctors first train with their relatives and teachers for 3 years ... otherwise nothing good will come of it + for advanced training. send more....
I completely agree with you. Now there are no real doctors, they don’t want to treat young people, and what can we say about pensioners. There is no medicine in our country, if you have immunity, you will survive, no one will help ...
Everything is really so. We did not have DOCTORS, as before. Now they are ignorant, soulless. Now the salvation of the drowning is the work of the drowning themselves.
Correctly
So from Digoxin is POISON !!! It is prepared from a poisonous plant and a little overdose - ventricular fibrillation immediately begins - and this is death.
Furosemide is the strongest diuretic - why oil is oil - after all, Concor also drives fluid like all hypotensive ...
Concor is NOT a diuretic and it is primarily prescribed NOT for pressure, but for ARRYTHMIA. And it is not clear why people and doctors are illiterate - everyone began to prescribe blockers (Concor) for pressure in a row. This is stupid and does not always solve the problem. Concor can be prescribed as an addition to antihypertensive drugs, if there is tachycardia or atrial fibrillation, but if CHF is already present. The drug is serious.
Kon cor is NOT FROM ARRYTHMIA!!!
I also didn’t understand why he was prescribed to me, with complaints of low blood pressure, there was no arrhythmia, and to everything the hair climbs from him strongly, I almost went bald
I have low blood pressure. Sudden attacks of tachycardia began 140 beats, an increase in pressure of 150/80, extrasystoles, an arrhythmic pulse. I took an attack of anaprilin. Prescribed Concor and grandoxin. I drink 1/4 of 2.5 mg., it became easier, the pulse does not increase, there are no arrhythmias, BUT hair began to crawl out and dryness in the eyes is impossible. I'm afraid to drink more concor
Concor, the instruction for the use of which characterizes it in detail, refers to highly effective means. It belongs to the group of beta-1-blockers of the second generation and is used as mono- and as part of complex therapy.
Concor tablets have a wide range of indications and are recommended for the prevention of certain diseases.
The medicine Concor consists of active and additional components. The active substance, according to the instructions for use, is bisoprolol fumarate. Stability, structure and speed of assimilation of tablets provide additional components.
Table 1. The composition and effect of the drug Concor
Main component |
|
| bisoprolol fumarate | Contribute to a mild decrease in blood pressure, normalizes the heart rhythm, stops and prevents the manifestations of coronary artery disease |
Excipients |
|
| Disubstituted calcium phosphate | Oxidizing agent, allows you to get the desired consistency |
| Corn starch | Provides texture and density |
| Silica | Hygroscopic, promotes the absorption of bisoprolol |
| Crospovidone | Accelerates the absorption of the drug, provides a quick onset of the effect |
| Magnesium stearate | preservative |
The Concor annotation contains data about the components used to obtain the shell. It is possible to purchase 10, 25 or 30 tablets in plastic blisters and a cardboard box. Instructions for use are attached.
Manufacturer
Concor - tablets for pressure, packaged in the Russian Federation by the company "Nanolek". Production is carried out in Germany by the Merck KGaA enterprise. This is one of the most famous and oldest pharmaceutical companies, dating back to the 1670s. Now it is an extensive network covering many countries.
Concor, the manufacturer of which has established itself in the market exclusively on the positive side, is included in the list of the most popular Merck KGaA drugs. The exact address of the company and its representative office in Russia is indicated in the instructions for use.
What is Concor from?
From the instructions for use, we can conclude that Concor has a wide range of indications. Recommended:
- To reduce blood pressure. Concor, the use of which contributes to the mild normalization of blood pressure, is prescribed with a regular increase in systolic and diastolic rates (140/90 mm Hg and above).
- As monotherapy or as part of the complex treatment of certain cardiovascular diseases.
- In order to carry out prevention to reduce the risk of death.
What Concor tablets look like, what they help with, in what doses they should be taken - described in the instructions for use. However, it is strictly forbidden to drink the drug without the consent of a specialist, even if there is evidence.
Mechanism of action
Concor, the active substance of which determines the effect of the drug, begins to produce an effect within 15-40 minutes after use. The highest concentration of bisoprolol in the blood is observed after 3-4 hours. The instructions for use indicate that the therapeutic effect persists for 24 hours. Beta 1-blocker bisoprolol is selective, i.e. does not affect the functioning of beta 2-adrenergic receptors. This reduces the number of possible side effects.
Table 2. The mechanism of action of the drug Concor
| Direction | Action Concor |
|---|---|
| Beta 1-adrenergic receptors are receptors located at the junction of neurons. Sensitive to adrenaline and norepinephrine. Stimulation of the receptors leads to an increase in the heart rate. | are blocked |
| Number and strength of heart contractions | Decreases |
| Conductivity | Oppressed |
| Renin - increases blood pressure and reduces the lumen of blood vessels | Concentration is reduced, synthesis is reduced |
| Sympathetic vascular tone | Decreases |
| CNS | Oppressed |
| HELL | going down |
| angina attacks | are shrinking |
At what pressure should I take it?
Concor is a drug that does not apply to emergency or one-time assistance. Tablets are recommended for exchange use over a long period of time.
The effectiveness of the drug can be assessed no earlier than 2 weeks after the start of therapy, and a stable effect is observed after 1.5–2 months.
If you take a pill only when you feel worse, then the prescribed pharmacological treatment will not give the proper result. Concor (the instructions for use at what pressure it is worth drinking a pill does not describe) must be taken regularly, based on the scheme recommended by the specialist.
Instructions for use
Concor (international name Concor) has a number of characteristics prescribed in the instructions for use. Before using the tablet, you must read the information.
Indications
The basis for prescribing the drug is an accurate diagnosis. Concor, the indications for which are few, is recommended for:
- Hypertension. It is used in the primary and secondary form of the disease. The decrease in blood pressure is due to a decrease in heart rate. However, the drug is not recommended for the treatment of hypertension, not accompanied by heart pain and other manifestations. On the question of whether Concor reduces pressure, it is quite possible to give a positive answer, but with a caveat. The full effect is observed after 14 or more days.
- Chronic HF. Description Concor reports that the remedy is ineffective in heart failure at the stage of decompensation.
- . Regular intake of tablets can reduce the frequency and severity of ischemic attacks.
In addition, the drug is used at a high risk of developing coronary artery disease and / or death.
With tachycardia
A fast heartbeat that causes pain is called tachycardia. This is not a separate disease, but a symptomatic manifestation of some pathological conditions. It mainly occurs against the background of vegetovascular dystonia, with incorrect functioning of the endocrine system, arrhythmias, etc.
Concor with tachycardia helps to normalize the pulse and heartbeat. However, it should be used carefully in the absence of increased pressure, this can lead to:
- excessive pressure drop;
- decrease in heart rate (bradycardia).
With arrhythmia
According to the World Health Organization, it is a heart rhythm that differs from normal sinus. The difference can be expressed in:
- frequency
- strength;
- contraction/excitation sequences.
Concor with arrhythmia of the heart is very effective. It helps to reduce the automatism of the heart and reduce the contractility of its tissues. Course reception allows you to weaken the peripheral vascular resistance. Concor with arrhythmias reduces the likelihood of death due to fatal forms of cardiac arrhythmias.
Dosage
Table 3. Variable dosage of Concor, based on the disease being treated
The dose of Concor 2.5 mg is extremely small for therapy in coronary artery disease and hypertension. A similar amount is recommended for HF. It should be noted that the treatment of this disease should be accompanied by regular monitoring of the patient's health status.
For best results, the instructions for use recommend following some rules. In particular:
- Take in the morning, at the same time.
- Do not break the integrity of the tablet. Crushing or rubbing is not recommended.
- You can take the drug regardless of food intake.
- It is necessary to drink a small amount of water.
During the bearing of a child, the drug is prescribed extremely rarely. A specialist can make such a decision only if the benefits to the health of the mother are commensurate with the risks to the embryo. In this case, you should carefully take Concor - side effects for women in position can cause:
- circulatory disorders of the placenta;
- decrease in heart rate in a child;
- low fetal blood glucose;
- disturbances in the development and growth of the embryo.
Instructions for use indicate that therapy during lactation is unsafe. There are no studies confirming the penetration / non-penetration of bisoprolol into mother's milk.
Prevention of arterial hypertension
Contraindications
Selective beta 1-blockers of the second generation do not have such a significant list of restrictions as their predecessors. Concor, contraindications to which are prescribed in the instructions for use, is prohibited if there are:
- individual intolerance to the components of the drug;
- violations of the conduction of the heart muscle;
- cardiogenic shock;
- violation of the acid-base balance in the body;
- acute heart failure;
- chronic type HF at the stage of decompensation;
- decreased heart rate (bradycardia);
- disturbances of peripheral blood supply;
- bronchial asthma in severe forms;
- atrioventricular blockade of the 3rd degree;
- hormonally active tumors;
- bronchial pathology with obstruction;
- Raynaud's syndrome, etc.
Instructions for use prohibit drinking the drug to children and adolescents under 18 years of age. Studies on the safety of tablets for them have not been conducted.
Side effects
Negative consequences occur at the initial stages of treatment. They are especially pronounced in patients with angina pectoris or low blood pressure.
Table 4. Side effects of Concor tablets and systems affected by them
| Heart/vessels | Lowering blood pressure, reducing the pulse (bradycardia); aggravation of heart failure, tachycardia (the doctor decides how to replace Concor with tachycardia and other phenomena) and so on |
| gastrointestinal tract | Heartburn, nausea, diarrhea, constipation, drug jaundice |
| CNS | Headache, weakness, decreased performance, etc. |
| sense organs | Hearing and vision disorders |
| Leather | Burning, urticaria, eczema, angioedema |
| reproductive system | Potency disorders |
| Respiratory system | Bronchospasm, asthma attack |
In some cases, after a few weeks after the start of drug consumption, side effects disappear. If this does not happen, then it is worth replacing the drug.
Effect on potency
The list of side effects of the drug includes disorders affecting the reproductive system. The negative effect of Concor on potency is expressed in a decrease in androgen synthesis. Taking the drug can lead to a reduction in erectile function and sexual desire.
Concor (side effects for men may lead to a desire to stop treatment) can be replaced with Nebivolol (Nebilet). This tool is highly selective and does not have such an effect on male power.
Overdose
It is worth taking the tablets according to the instructions for use and the doctor's recommendations. Concor, an overdose of which is quite dangerous, in excess entails:
- bradycardia;
- lowering blood pressure;
- heart rhythm disturbances;
- excessive decrease in blood glucose levels;
- exacerbation of heart failure.
If you suspect an overdose of the drug, you need to call an ambulance.
The drug is prescribed mainly for a long period. As a rule, patients do not always manage to refrain from consuming alcoholic beverages for such a long time. It is possible to combine alcohol with a drug subject to the measure of intoxicating, however:
- It is not recommended to drink alcohol at the beginning of treatment. At this stage, even a small amount of alcohol can cause negative consequences.
- It must be remembered that combining Concor with alcohol can cause bradycardia, lowering blood pressure, or exacerbating heart disease.
If possible, the use of the drug and alcohol together should be avoided. Alcohol and Concor, the harm of which, when taken together, is very pronounced, can even lead to death.
This medicine has a similar brand name but is different:
- Composition. It has 2 active substances - bisoprolol and amlodipine (slow calcium channel blocker). The excipients are also excellent.
- Manufacturer. AM is a medicine produced by a Hungarian company.
- At the cost. AM costs twice as much.
To evaluate other differences will allow the study of instructions for use. Concor AM refers to combination therapy and has a more pronounced effect.
Concor Cor is an analogue, but has some differences in the amount of active substance and scope. The drug is produced by the same company. Take in the morning with a small amount of water.
Concor is a drug used to lower blood pressure, treat coronary artery disease, and treat chronic heart failure. It includes 5 or 10 mg of the active substance. Concor Cor contains 2.5 mg of bisoprolol. For the treatment of arterial hypertension or coronary artery disease, such a low dosage is not suitable.
It is used exclusively as part of combination therapy for HF.
Can pills be harmful?
According to the instructions for use, the drug can have a negative effect in a number of cases:
- with unauthorized uncontrolled use;
- in case of incorrect appointment (for example, if the patient has contraindications);
- with an incorrectly calculated dosage;
- when used together with a number of drugs (for example, antihypertensive drugs);
- upon abrupt cessation of treatment.