Xanthinol nicotinate: instructions for use, special information and instructions. Why is Xanthinol Nicotinate prescribed: instructions for use of tablets and injections Xanthinol nicotinate tablets instructions for use

1 tablet contains 150 mg of the active ingredient xanthinol nicotinate.

1 ml solution for injection contains 150 mg of the active ingredient xanthinol nicotinate , as well as injection water.

Release form

The drug is available in the form of a solution, in a tablet dosage form.

pharmachologic effect

Vasodilator.

Pharmacodynamics and pharmacokinetics

The drug has the properties and drugs of the group theophylline: improves collateral circulation , expands the lumen of peripherally located vessels, has a pronounced antiplatelet effect , enhances the process of ATP synthesis and oxidative phosphorylation.

The principle of action is based on substrate stimulation of the synthesis of NAD-phosphate and NAD, on an increase in the intracellular content of cAMP, on blocking phosphodiesterase and adenosine receptors.

Xanthinol Nicotinate improves tissue nutrition, their oxygenation, microcirculation . With prolonged use, there is an increase in the activity of lipoprotein lipase, a decrease in the concentration atherogenic lipids and , fibrinolysis processes are activated, it is noted antiatherosclerotic effect , aggregation decreases, blood viscosity decreases.

The drug reduces the severity of the effects of cerebral hypoxia, enhances cerebral circulation , promotes an increase in the IOC, enhances myocardial contraction, reduces OPSS.

The drug is characterized by a "nicotine-like syndrome", which manifests itself as an exacerbation of the sensitivity of taste and olfactory sensations due to hyperesthesia of the mucous membranes of the oral and nasal cavities.

Indications for use

Xanthinol Nicotinate is prescribed for Raynaud's disease, Buerger's disease (thromboangiitis obliterans) obliterating vessels of the extremities, with retinopathy, Meniere's syndrome , with migraine, bedsores, trophic ulcers of the lower leg, with post-thrombophlebitic syndrome , with acute (with damage to the superficial or deep veins), with diabetic angiopathy, cerebrovascular insufficiency, with Bushke's scleredema, scleroderma, cerebrovascular accident, with atherosclerosis of cerebral vessels, with hypertriglyceridemia , hypercholesterolemia, atherosclerosis of the coronary arteries, with postpartum and intrauterine fetal asphyxia, with dermatoses against the background of disturbed trophism of vascular genesis.

Contraindications

Xanthinol Nicotinate is not prescribed for severe pathology of the renal system, during pregnancy, arterial hypotension , peptic ulcer of the digestive tract in the acute stage, with mitral stenosis, intolerance to the active substance, with acute bleeding , decompensated form of CHF, with acute heart failure, with acute.

Side effects

Instructions for use of Xanthinol Nicotinate indicate the following possible side effects: fever, drop in blood pressure, gastralgia , loss of appetite, diarrhea, nausea, weakness, flushing of the skin.

Instructions for use Xanthinol Nicotinate (Method and dosage)

The medicine is used intramuscularly, intravenously (drip, jet) or inside.

Instructions for tablets

Tablets are recommended to be swallowed whole. Reception scheme: three times a day, 150 mg. In some cases, the amount of the drug is increased to 300-600 mg (single dose). With positive dynamics, the dosage is gradually reduced. The duration of therapy is at least two months.

Xanthinol Nicotinate solution, instructions for use

Intramuscular the drug is administered as a 15% solution of 2-6 ml for 2-3 weeks.

Intravenously the drug is injected in a stream 1-2 times a day, 2 ml in the form of a 15% solution (the patient must lie on the couch during the procedure). The duration of treatment is 5-10 days. Intravenous drip injections are carried out at a rate of 40-50 drops/minute. Previously, 10 ml of 15% of the drug is diluted in sodium chloride solution (0.9% 200 ml) or in dextrose solution (5% 200-500 ml).

When diagnosing acute disorders of blood supply to tissues, in addition to parenteral administration, a medication is simultaneously prescribed in a tablet dosage form three times a day, 300 mg each.

Overdose

The use of Xanthinol Nicotinate in high doses for a long time leads to hyperuricemia , increased levels of liver enzymes, changes in glucose tolerance. Overdose causes vomiting, epigastric pain , drop in blood pressure.

Interaction

Xanthinol Nicotinate should not be used with MAO inhibitors . With extreme caution, the drug is prescribed with simultaneous therapy (a sharp increase in the effect is noted), antihypertensive drugs (sympatholytics, alpha blockers , ergot alkaloids, beta-blockers, ganglioblockers).

Terms of sale

Requires a prescription.

Storage conditions

In a dark place inaccessible to children at a temperature of 15-25 degrees Celsius.

Best before date

No more than three years.

special instructions

It is unacceptable to prescribe the drug Xanthinol Nicotinate in the first trimester. In the second and third trimester, the drug is used subject to careful monitoring of the patient.

Prescribing a medication in large quantities causes dizziness and a drop in level.

It is necessary to avoid getting the drug on the mucous membranes, in the eyes.

Analogues of Xanthinol Nicotinate

It has no structural analogues.

Producer: JSC "Binnopharm" Russia

ATC code: C04AD02

Farm group:

Release form: Liquid dosage forms. Injection.

General characteristics. Compound:

Pharmacological properties:

Indications for use:

Important! Get to know the treatment

Dosage and administration:

Application Features:

Side effects:

Interaction with other drugs:

Storage conditions:

Store in a place protected from light at a temperature not exceeding 25 ° C. Keep out of the reach of children. Shelf life - 3 years. Do not use the drug after the expiration date indicated on the package.

Leave conditions:

On prescription

Package:

Solution for intramuscular and intravenous administration of 150 mg / ml, 2 ml in ampoules. 5 ampoules in a blister pack made of polyvinyl chloride film. 1 or 2 blister packs with a ceramic ampoule scarifier or a knife for opening ampoules and instructions for use in a cardboard pack. When using ampoules with a break ring or break point, do not insert a knife or scarifier.

Result: positive feedback

Good angioprotector

Benefits: Does not cause serious side effects

Disadvantages: Quite a large number of contraindications for use

I am 62 years old and it is natural that atherosclerosis of vessels developed against the background of high cholesterol in the blood. This phenomenon is common to all people of age. I turned to my therapist and he prescribed me the above drug, it improves cerebral circulation, dilates blood vessels, performs angioprotection. But the drug is available in solution, so the poem has to be injected intravenously, and this is not always convenient, rather than just taking a pill ... In general, after the course of treatment, the results of the tests were a pleasant surprise. But I strongly recommend not to self-medicate, but to coordinate everything with your doctor! Do not be ill! :)

Result: positive feedback

Helps with dizziness

Advantages: efficient, low cost

Cons: none

We consume this drug together with our father, every time we feel that our pressure is lowering. It's easy to understand - your head starts to spin and the world blurs a little before your eyes. You can buy tablets at any pharmacy without a prescription. Taken after meals. You can take two to four tablets at a time. Of course, I do not advise anyone to buy a product just like that, without the recommendations of specialists. The tool is also sold in the form of injections, but I personally feel uncomfortable doing them. There were no side effects from the tablets. Dizziness passes quickly enough, the pressure gradually returns to normal. The smallest package of tablets costs only 23 rubles.

Result: positive feedback

Pros: cheap

Cons: side effects

My head has recently begun to hurt very often, I don’t know what it is connected with, probably due to constant stress at work, and in the family everything was not very smooth. After consulting with a doctor, I bought Xanthinol Nicotinate tablets. There are tablets and injections, but I chose tablets because I am terribly afraid of injections. I drank them according to a special course that the doctor prescribed for me and the result did not have to wait long. After about a week, everything was already fine, my head didn’t hurt and life became easier.

Result: neutral feedback

There are benefits, but it is better to drink it for a short time so as not to get harm

Benefits: Inexpensive, lowered cholesterol and platelet levels, improved circulation, relieved headaches and dizziness, had a nootropic effect

Disadvantages: Causes stomach pain and nausea over time, harms the liver, caused an increase in blood sugar

I saw the benefits of the drug after a month of taking it. I passed the tests, and there the cholesterol decreased, and the level of platelets. Not very strong, but in a month the result was worthy. The state of health also improved, hands and feet stopped constantly freezing, the legs no longer swelled and hurt so much, the swollen vein became less noticeable, the head began to hurt and spin less often, and attentiveness and concentration increased noticeably. The pressure also went down, albeit slightly. In the first month of treatment, the side effects were only an eternally red face and a tingling sensation, but in the second month my stomach began to ache and bitterness appeared in my mouth, after eating it became nauseous. Then the liver rebelled, and for some reason sugar began to rise, the drug had to be canceled. But the effect of treatment persisted for another 3-3.5 months for sure.

Result: positive feedback

Improves blood circulation

Benefits: really helps

Disadvantages: discomfort after injection, not sold in tablets

Xanthinol nicotinate is a good and effective drug, but the only bad thing is that you can’t buy it in tablets in pharmacies. This drug was administered intramuscularly in stationary conditions. I will say that the injection itself is painless, but after it the sensations are not pleasant. I was injected with only 2 ml of the drug, and literally in a minute the whole body began to burn, it turned red and the pulse increased greatly. There was a feeling that the whole body was pierced with needles. In order to somehow alleviate my condition, I drank a lot of water. But after completing the prescribed course, my dizziness stopped and this is the main thing.

Result: neutral feedback

Latin name: Xantinol nicotinate
ATX code: C04AD02
Active substance: Xanthinol nicotinate
Manufacturer: USOLIE-SIBIRSKY
KHIMFARMZAVOD, Russia
Vacation from the pharmacy: On prescription
Storage conditions: t from 15 to 25 C
Best before date: 3 years.

Xanthinol nicotinate is one of the vasodilating drugs that contributes to the normalization of microcirculation.

Indications for use

The use of Xanthinol nicotinate is indicated for:

• Poor circulation in the brain
• Diagnosis of Raynaud's or Buerger's disease
• Signs of endarteritis obliterans
• The occurrence of diabetic angiopathy
• The development of Meniere's syndrome
• Asphyxia of the newborn (both intrauterine and postpartum)
• Scleroderma, including Bushke's scleredema
• The occurrence of dermatoses provoked by a violation of trophism
• The appearance of bedsores, with poorly healing wounds, trophic ulcerations on the legs
• Development of post-thrombophlebitic syndrome
• Diagnosis of thrombosis, as well as vascular embolism
• Hypertriglyceridemia and hypercholesterolemia
• Atherosclerotic changes in blood vessels (both coronary and cerebral)
• Obliterating atherosclerosis affecting the vessels of the extremities.

Composition and forms of release

Xanthinol nicotinate (tablets) contains one active substance, represented by xanthinol nicotinate, its mass fraction in 1 pill is 150 mg. Also present:

• Ca stearate monohydrate
• Milk sugar
• Povidone
• Corn starch.

1 ml of the solution contains the same amount of active ingredient as 1 pill. An additional component is water for injection.

A colorless injection solution of xanthinol nicotinate is poured into ampoules of 2 ml, inside the pack there are 10 amps.

Rounded tablets of a milky-white shade are placed in a blister. pack of 10 pcs. There are 6 blisters in a pack. packages.

Medicinal properties

The price of tablets: from 120 to 290 rubles.

The drug is characterized by the properties of nicotinic acid itself and a number of agents from the theophylline group. Under the influence of the drug, normalization of collateral circulation is observed, the lumen of peripheral vessels expands. At the same time, an antiaggregant effect is recorded, the process of oxidative phosphorylation is accelerated, as well as the production of ATP.

The mechanism of action is based on stimulation of the synthesis of NAD-phosphate, as well as NAD, an increase in the concentration of cAMP inside cells, blocking adenosine receptors and phosphodiesterase itself.

The medicine promotes better tissue nutrition, oxygenation of cells, and activates microcirculation.

In the case of prolonged use of the drug, activation of lipoprotein lipase is recorded, while the level of cholesterol and atherogenic lipids is significantly reduced, and fibrinolysis is stimulated. Along with this, a pronounced anti-atherosclerotic effect is observed, aggregation of platelet cells decreases, blood viscosity decreases.

Under the action of the drug, the consequences of the transferred cerebral hypoxia are eliminated, blood circulation in the brain is normalized, the IOC increases, the contractile function of the myocardium is activated, and OPSS decreases.

The drug can provoke the development of the so-called nicotine-like syndrome, which is expressed by an increase in the susceptibility of taste buds and olfactory sensations, this is due to hyperesthesia of the mucous membranes.

Xanthinol nicotinate: instruction

The drug can be used in / m, in / in, or it is prescribed for oral administration.

How are the tablets used?

It is recommended to drink pills three times a day, 1 tab. In some cases, the standard dosage may increase, for one application the doctor may prescribe 300-600 mg of drugs. In the case of a visible therapeutic effect, a gradual decrease in the dose taken is possible. The duration of therapy is about 2 months.

How is the injection solution used?

Solution price: from 45 to 194 rubles.

Intramuscularly: the drug is administered in the form of a 15% solution with a dosage of 2 to 6 ml, injections are given over the next 2-3 weeks.

Before intravenous administration, the patient should take a supine position, the infusion is carried out 1-2 p. throughout the day, 2 ml of a 15% solution is injected in one procedure. The duration of therapeutic therapy is from 5 to 10 days.

Drip infusion is carried out at a rate of 40-50 drops. for 1 min. before the procedure, a 15% solution (10 ml) must be diluted with 200 ml of a 0.9% saline solution or 200-500 ml of a 5% dextrose solution.

If a deterioration in blood supply is detected, in addition to the injection of the drug, pills are prescribed at a dose of 300 mg three times a day.

Contraindications and precautions

You should not start treatment with the drug (injection or pills) with:

• Ulcerative ailments of the gastrointestinal tract
• Diagnosis of myocardial infarction
• Pathologies of the cardiovascular system, renal system
• The presence of excessive susceptibility to the components
• Detection of acute bleeding
• Low blood pressure
• Development of glaucoma
• mitral stenosis
• During pregnancy (1 trimester)
• Determination of the decompensated form of CHF.

With caution, the use of the drug in the 2nd and 3rd trim is prescribed. pregnancy and lactation period.

During treatment, it is worth giving up driving.

The solution should not get on the mucous membranes.

Cross-drug interactions

You should not use drugs based on MAO inhibitors at the same time.

When using strophanthin, there may be an increase in the action of xanthinol nicotinate.

With caution should be taken:

• Means-sympatholytics
• Medicines based on α- and β-blockers
• Ergot alkaloids
• Ganglioblockers.

Side effects and overdose

During the use of drugs, the following side symptoms may occur:

• Diarrhea
• Gastralgia
• Increase in body temperature
• Decreased blood pressure
• Loss of appetite
• lethargy
• Skin hyperemia
• Bouts of nausea
• Strong dizziness.

When taking overdoses and long-term therapeutic therapy, hyperuricemia may develop, the index of liver enzymes increases sharply, and a violation of glucose tolerance is recorded. Emergence of epigastric pains, decrease in the ABP, vomiting is not excluded.

Symptomatic treatment should be started.

Analogues

To date, there is no drug that would be identical in composition to Xanthinol nicotinate, analogues can be selected according to a similar mechanism of action.

Zentiva, Slovak Republic

Price from 130 to 270 rubles.

Agapurine is an antiaggregatory drug that promotes vasodilation and improves microcirculation. The drug is prescribed for the treatment of various vascular disorders. The active ingredient is represented by pentoxifylline. Available in the form of an injection solution and tablets.

Pros:

• Reduces the severity of pain
• Used after a stroke
• Low price.

Minuses:

• Contraindicated in myocardial infarction
• Not intended for pregnant women
• Can provoke the progression of angina pectoris.

Vasodilator drugs in medical practice are represented by a group of tablets, capsules, solutions. Instructions for use Xanthinol nicotinate will help you take the drug correctly and protect yourself from undesirable consequences.

Xanthinol nicotinate: therapeutic effect

Xanthinol nicotinate is a vasodilator

Xanthinol nicotinate is a medicine that provides first aid to blood vessels. Belongs to an extensive group of vasodilators. It is used in medicine for the treatment of vascular diseases: heart, brain, lower and upper limbs, spine.

The drug contains two components: nicotinic acid and theophylline.

Nicotinic acid is vitamin B3. Helps with metabolic disorders, participates in protein metabolism. Expands blood vessels, stimulates the gastrointestinal tract. Lack of nicotinic acid worsens the state of the nervous system, causes irritation of the mucous membranes and skin. In the patient's body, the level is disturbed.

Theophylline - stimulates the nervous system, reduces the myocardium, has a bronchodilatory effect. Expands coronary vessels. Is a diuretic.

The main element of the drug is xanthinol nicotinate. Each ampoule or tablet contains 150 mg of this substance. In addition to it, the composition includes: milk sugar, calcium stearate, corn starch and povidone, as an enterosorbent.

The drug has a vasodilating and antisclerotic effect. Reduces the likelihood of blood clots.

Xanthinol nicotinate repeats the composition of nicotinic acid. Acts as medicines used in the treatment of respiratory diseases. Easily soluble in distilled water, poorly soluble in alcohol.

Medicinal properties:

• Improves blood circulation in the brain
• Expands blood vessels
• Enriches the body with oxygen
• Lowers lipid levels
• hinders development
• Dissolves blood clots
• Accelerates blood circulation in the myocardium

Xanthinol nicotinate is instantly absorbed in the digestive tract. After some time, it is converted into nicotinic acid and theophylline. It is excreted from the body with urine. With intramuscular injections, improvement is observed after 10 minutes.

Watch a video about vitamin B3:

Application

Xanthinol nicotinate is used for vascular atherosclerosis

Xanthinol nicotinate is used in many branches of medicine. Used for pathologies, diseases and conditions:

• Raynaud's disease
• Meniere's syndrome
• Buerger's disease
• vascular atherosclerosis
• migraine
• bedsores
• dermatosis
• arterial
• spicy
• fetal asphyxia postpartum and intrauterine
• trophic leg ulcers
• pathology of the blood vessels
• festering wounds

The duration of treatment depends on the disease. This is 5 - 10 days.

Method of administration

Since the drug is produced in different forms, there are three ways to take it: in a vein, intramuscularly and orally.

Tablets are prescribed for adults. Take after meals, whole. Assign a tablet 3 times a day. On the recommendation of a doctor, the dose is gradually increased to 3 tablets three times a day. Treatment lasts one and a half to two months.

Injections into a vein are made in the morning and in the evening, 2 ml each. The patient is lying at this time.

Intramuscular injections are given from 2 to 6 ml per day for two weeks.

If the patient suffers from severe circulatory disorders, then he is prescribed pills and injections at the same time.

Ophthalmologists treat the eyes with a solution of the drug. Used for drug electrophoresis 300 mg per procedure. Iontophoresis is done for 20 days.

Contraindications

Do not take Xanthinol nicotinate with hypotension

• stomach ulcer
• Migraine
• Glaucoma
• The presence of bleeding
• kidney disease
• Mitral
• Pregnancy, first trimester
• Childhood
• Breast-feeding
• Postoperative period
• Allergy to the composition of the drug
• Individual intolerance

Side effects

A side effect of taking Xanthinol Nicotinate may be chest pain on the left

Xanthinol nicotinate affects the human condition. There is nausea, weakness. , heat is felt, the skin of the face, neck and head turns red.

Appetite disappears, the work of the stomach is upset. All signs disappear 15-20 minutes after taking the medicine. Stopping treatment is not worth it.

The body systems react to the side effect:

1. Nervous system - there is a sharp headache, dizziness, sometimes nausea. Symptoms disappear after 10 minutes.
2. Cardiovascular system - pressure decreases, appears. The rhythm of the heart is disturbed.
3. Endocrine system - if the drug is taken for a long time and in large doses, then the body reduces glucose tolerance.
4. Digestive tract - indigestion and diarrhea, nausea and weakness. The amount of liver transaminases in the patient's blood increases.
5. Respiratory system - sometimes the patient feels a lack of air, shortness of breath worries.

Often, when taking Xanthinol nicotinate, rashes on the skin, itching, burning appear. Increases blood flow to the face and neck, causing them to turn red. Quincke's edema sometimes occurs. The content of uric acid in the blood increases.

With the appearance and intensification of side symptoms, it is recommended to immediately consult a doctor. If unwanted effects persist, stop treatment.

Overdose

Acute abdominal pain may indicate an overdose of Xanthinol nicotinate.

The drug Xanthinol nicotinate is considered non-toxic, it rarely causes poisoning. However, when taken in high doses for a long time, the level of liver enzymes exceeds the norm. Uric acid builds up in the blood, and the body loses its ability to carry glucose.

With an excess of the drug in the body, the patient develops acute abdominal pain, diarrhea, weakness. When these symptoms occur, doctors prescribe symptomatic therapeutic treatment.

Alcohol compatibility

Be careful with the use of alcohol. Wine, beer, vodka, champagne and other strong drinks affect the effectiveness of treatment and the effect of the drug.

It is allowed to take alcohol a day before taking the medicine for men, and for a day and a half - for women. After taking the medicine, women can drink alcohol after 20 hours, for men - after 14.

If there are symptoms of alcohol incompatibility with the drug, stop treatment, drink more water, consult a doctor for advice.

drug interaction

It is undesirable to use Xanthinol nicotinate and Heparin at the same time.

To avoid a decrease in pressure, Xanthinol nicotinate should not be taken simultaneously with antihypertensive drugs. It is also undesirable to take it simultaneously with strophanthin, antidepressants, heparin, fibrinolysin.

During injections, it is forbidden to mix in a syringe with other solutions.

Analogues

All drugs have analogues. They have identical medicinal properties. Synonyms are called drugs with the same main substance in the composition.

The most famous analogues:

• Theoverine
• Theodibaverine
• Theobromine
• Teminal

Synonyms are:

• Angioamine
• Megemin
• Vedrine
• Xavin
• Sadamin
• Complamin
• Theonikol
• Complamex
• Vincanor

The doctor should prescribe analogues or synonyms of the drug.

Important Notes

While taking the drug Xanthinol nicotinate and cardiac drugs, it is necessary to periodically do an ECG

1. Avoid contact of aqueous or alcoholic solution with eyes and mucous membranes.
2. At the same time taking cardiac drugs, a doctor's examination is necessary. Be sure to do.
3. Use with caution in patients with low blood pressure. Perhaps a decrease in pressure, development.
4. It is not advisable to drink Xanthinol nicotinate during pregnancy. Sometimes the doctor prescribes it in the second, third trimester, in exceptional cases, and under control.
5. For people with renal or hepatic insufficiency, the drug is prescribed in small doses. Then increase.
6. Often taking pills, injections causes weakness, dizziness, and a decrease in blood pressure. Therefore, upon admission, refuse to drive a car and other vehicles. You can not work on conveyors.
7. Under medical supervision, take the drug to patients with atherosclerosis, heart failure and the elderly.
8. Diabetics need to check their blood glucose readings, more often to take an analysis.
9. With prolonged treatment with high doses, the drug should be discontinued.
10. It is forbidden to use Xanthinol nicotinate with strong coffee, alcohol.

Released by prescription only. Store the medicine in a dark place at 25°C. Shelf life is three years. Do not give to children!

Xanthinol nicotinate is a necessary medicine, the value of which lies in the properties of the main active substances.