Livarol during feeding. Livarol vaginal suppositories - instructions for use in gynecology

Treatment of thrush with vaginal suppositories with antifungal components gives the greatest effect and allows you to achieve a quick result. You can buy these drugs at a pharmacy without a prescription, but it is advisable to consult a doctor before using Livarol suppositories: what they are prescribed for, how to take them, can they be replaced with analogues if necessary.

Candles "Livarol" contain ketoconazole as an active ingredient. This substance has a fairly wide spectrum of action, including against fungi and bacteria. Ketoconazole is part of many antifungal drugs and is most effective as a topical antifungal agent.

Additional substances (the basis for suppositories) make the treatment much more effective:

• shape and facilitate the insertion of the suppository into the vagina;
• reduce the intensity of inflammation;
• soften the mucous membrane;
• help heal minor injuries.

Candles give only a local effect for fungal inflammation of the vagina and labia, but are ineffective against fungal cystitis and more serious diseases. However, in this case they can also be used in complex therapy.

Indications for use

Candles from thrush Livarol are prescribed for the following pathologies:

• With candidal vulvovaginitis (inflammation of the walls of the vagina and skin of the labia). In this case, they are the main means for treating the disease.
• With candidal cystitis and endometritis, suppositories are prescribed as part of complex therapy along with systemic drugs.
• Can be used to prevent candidiasis during long-term treatment with antibiotics or glucocorticosteroids.
• In chronic and recurrent candidiasis, suppositories are used to relieve exacerbation. In this case, the drug is an element of complex therapy, since the fight against the fungus in the vaginal area is not enough.

Also, "Livarol" can be used as a prophylactic agent for candidiasis of other areas of the body in order to prevent the spread of infection to the genitals.

Contraindications

Candles "Livarol" can not be used if hypersensitivity to the components of the drug or to the active substance is detected.

Stop taking and consult a doctor if the following symptoms appear:

• discomfort;
• pain in the genital area;
• swelling;
• deterioration in general well-being.

The second important contraindication is early pregnancy (up to 12 weeks). At this point, Livarol candles can have a negative impact on the development of the child. After this period and during breastfeeding, these suppositories should be used with caution. It is necessary to consult with a gynecologist so as not to harm your health and the health of the unborn baby.

When using suppositories during lactation, it is sometimes advisable to stop breastfeeding for the duration of treatment.

Method of application, dosage

Livarol - suppositories from thrush, they are inserted into the vagina and dissolve there, providing a local effect.

Mode of application:

1. Before the introduction of the suppository, it is necessary to thoroughly wash the genitals and wipe the perineum dry.
2. Then you need to lie on your side and insert the candle with the pointed end forward.

The candle will dissolve itself in a few minutes. The instruction recommends lying down for about an hour after the procedure so that the active substance is completely absorbed. Therefore, it is best to use the drug in the evening before bedtime.

The dosage of the drug depends on the purpose of its appointment:

• For the treatment of acute candidiasis, a suppository is administered every day at night for 5 days.
• If candidiasis is chronic or recurrent, the duration of the course increases to 10 days.
• The prophylactic course lasts 5 days, begins the next day after the end of menstruation, if necessary, repeats monthly.

It should be noted that when suppositories from thrush Livarol are prescribed, the instruction does not recommend using during menstruation, since then their effectiveness is much lower - the active substance is partially lost along with menstrual flow.

It is better to use the drug in the evening, and not in the morning - then the loss of the active substance is excluded along with secretions when walking and running.

In addition, in the morning, the patient may not have time to lie down for an hour after the procedure.

Possible side effects

Candles are one of the safest dosage forms, but nevertheless, their use is associated with certain side effects. These may be local or general allergic reactions in the patient. Therefore, it is necessary to monitor your condition and, if it worsens, stop taking the drug in time and inform your doctor.

Local allergic reactions can be not only in the patient herself, but also in her sexual partner. To prevent them, it is necessary to take a break in intimate life until complete recovery. In general, not useful for both partners.

For women undergoing treatment and using Livarol suppositories, the instructions for use for thrush warns of more abundant discharge than usual. This is due to the fact that ketoconazole causes the death and release of dead fungi along with mucus and curdled secretions. It is advisable to use panty liners during treatment to keep the linen clean.

The use of tampons can lead to the maintenance of inflammation and worsening of the general condition.

Paradoxical as it may seem, but Livarol suppositories help from what, the disease can be provoked. If the drug was used incorrectly, for example, a woman stopped using suppositories before it was prescribed by a doctor, then there is a great danger of a recurrence of thrush. In addition, fungi have the ability to develop tolerance to antifungal drugs, although much less than bacteria. Therefore, with constant misuse of "Livarol" may develop.

Features and limitations of application

An overdose of "Livarol" in clinical trials has not been noted. There are indications that when several suppositories are inserted in a row, discomfort occurs in the vaginal area, and a severe allergic reaction is possible. These phenomena pass independently and rather quickly.

The use of suppositories in girls under 12 years of age is not recommended. There is no reliable data on the danger or safety of such treatment. Assign "Livarol" to children only if there is laboratory confirmation of the diagnosis of genital tract candidiasis.

In no case should you use the drug in girls without a doctor's prescription.

conclusions

Candles "Livarol" from thrush is an effective remedy, but it is important to strictly follow the instructions and prescriptions of the doctor. If this is not done, then their use may not only fail, but also lead to the opposite effect - relapses and chronicity of the disease.

And some secrets... Have you ever tried to get rid of thrush? Judging by the fact that you are reading this article, the victory was not on your side. And, of course, you know what is:

• white curdled discharge;
• severe burning and itching;
• pain during sex;
• bad smell;
• discomfort when urinating.

The only remedy for thrush and diseases caused by Candida fungi, recommended by our subscribers!

Every woman at least once in her life faced such an unpleasant disease as thrush. The reasons that can cause candidiasis are different. It is necessary to start treatment of the disease in time to prevent recurrence. Many different means are used for treatment. Deservedly won a leading place in the top effective drugs Livarol.

Candles Livarol: a unique composition

If you start treatment at the initial stage, then the disease can be effectively and quickly cured. As a rule, at the first symptoms of thrush, doctors recommend using Livarol. The composition of suppositories includes ketoconazole. It has a destructive effect on fungi. The medicine also contains other excipients that uniqueize the composition of the drug.

Ingredients of Livarol:

• Ketoconazole (40 milligrams);
• Polyethylene oxide (400 and 1500 milligrams);
• Butylated hydroxyanisole.

When is Livarol used for thrush?

Candles Livarol are used not only for the treatment of thrush, but also for other diseases:

• with disturbed microflora of the vagina (most often this happens during pregnancy);
• with a chronic form of candidiasis that recurs;
• with chronic and acute mycosis.

Also, Livarol suppositories can be used prophylactically to prevent thrush. They can increase the effectiveness of drugs during antibiotic therapy. Candles can be prescribed to a woman who has had an infectious disease when her immune system is weakened. In such a situation, Livarol helps prevent candidiasis.

Contraindications to the use of the drug from thrush

It is best to start treatment with livarol immediately after the end of menstruation. This mode of application is also good because during this period of time the concentration of estrogens in the woman's blood begins to gradually increase. Thus, in place of the fungi “destroyed” by ketoconazole, normal lactobacilli will populate, as a result of which, after a short course of treatment, the normal microflora of the vagina will be completely restored.

Why do white vaginal discharge appear after using livarol suppositories?

Livarol is an antifungal drug that is injected into the vagina to treat vaginal candidiasis ( that is, lesions of the vagina with pathogenic fungi). As the infection develops, the number of candida in the vagina increases, as a result of which, over time, they can cover the entire surface of the mucous membrane, acquiring the appearance of a white, cheesy plaque. The main treatment for vaginal candidiasis is the intravaginal administration of antifungal agents, such as livarol suppositories. The active substance of this drug is ketoconazole, which has an antifungal effect ( that is, upon contact with pathogenic fungi, it destroys them). In addition to ketoconazole, the suppository contains other components that ensure that the required form of the drug is maintained until it is used.

After insertion into the vagina the temperature in which can reach 37.5 degrees) the suppository melts, as a result of which the active substance covers a large surface of the mucous membrane and contacts the fungal colonies located on it, which then die. Dead colonies of fungi ( which are white curdled masses) are detached from the mucous membrane of the vagina and are released along with the molten substance of the suppository to the outside.

After the end of treatment, fungal colonies do not remain in the vagina, as a result of which the pathological discharge stops.

Can I have sex while taking Livarol?

Livarol is an antifungal drug that comes in the form of vaginal suppositories and is used to treat vaginal candidiasis ( lesions of the vaginal mucosa by pathogenic fungi of the genus Candida). For maximum effectiveness, suppositories should be inserted deep into the vagina. The suppository inserted into the vagina melts, as a result of which its active substance ( ketoconazole) comes into contact with pathogenic fungi located on the mucous membrane and destroys them.

The antifungal effect of the drug persists for several hours, as a result of which candles should be used 1 time per day ( at night before bed). If a woman had sexual intercourse before the introduction of the candle, this will not affect the effectiveness of the treatment or the health of the woman herself. The most formidable complication in this case may be reddening of the mucous membrane of the partner's penis, due to the action of the previously administered drug. The development can be prevented with the help of condoms, which should be used during the entire period of treatment ( 5 – 10 days).

If sexual contact took place during the first hours after the administration of the drug, the possible consequences may be more formidable. The likelihood of damage to the partner's penis can also be eliminated with a condom, but the effectiveness of the treatment itself in this case will be significantly reduced. The fact is that during sexual intercourse, most of the dissolved drug is mechanically removed from the surface of the vaginal mucosa. This is also facilitated by increased activity of the glands of the vagina. As a result, after the end of the course of treatment, a certain proportion of fungi may survive, leading to a relapse ( re-aggravation) disease or its transition to a chronic form.

Thrush is the most common disease in women that occurs at any age. The slightest violation of the hormonal background and a decrease in immunity negatively affects the state of the reproductive system. Various means are used to treat the disease, but the most popular remedy is vaginal suppositories. But, unfortunately, no matter how effective the drug is, ignorance of its features can lead to refusal to use it. So, discharge after Livarol by some women is considered a lack of medicine or a side effect. But is it really so?

Reasons for the development of thrush

Thrush (or vaginal candidiasis) is a common infectious disease that almost every woman has encountered. According to medical data, the disease affects 75-80% of the weaker sex.

The disease is provoked by fungi of the genus Candida. The developed pathology is not contagious, not sexually transmitted. These microorganisms are present in the reproductive system of every female representative. In a normal state of immunity, fungi usually do not manifest themselves, since their increased reproduction is controlled by special lactobacilli present in the vagina and providing the necessary acidic environment.

But as soon as there is a failure in the microflora, and beneficial organisms reduce their activity, the acidity in the body decreases. The more the pH approaches neutral, the more favorable the conditions for the reproduction of candida become. They begin to multiply intensively, penetrating the mucous membrane and causing an inflammatory process in the vagina.

The reasons for the development of thrush are:

• Decreased body immunity due to diseases, poor lifestyle, poor hygiene and other factors.
• Therapy with antibiotics. The use of strong antibacterial drugs contributes to the destruction of not only pathogenic, but also beneficial lactobacilli. And since antibiotics do not affect fungi, they get excellent conditions for reproduction.
• Contraceptives, due to the sex hormones they contain, change the hormonal background in the female body, which can cause infection.
• Cytostatic drugs: inhibit cell division in the body, reducing immunity.
• Glucocorticoids: a side effect of drugs is a decrease in the body's defenses.
• Diabetes. A person with this disease has reduced immunity, there are circulatory disorders. As a result of insufficient supply of cells and tissues with useful substances, favorable conditions are created for the development of infection.
• AIDS: An extremely low level of immunity contributes to the active spread of pathogens.
• Untreated thrush in a pregnant woman. In addition to the consequences for women's health, the infection is transmitted to the child during childbirth.

Manifestations of thrush

An infection that has developed in the vagina signals its presence with several unpleasant symptoms:

• Itching and burning. Signs associated with inflammation are especially pronounced at night, after bathing or procedures, intimacy.
• Specific discharge from the vagina - thick masses, similar to cottage cheese.
• If they occur in the vagina, this is due to developed inflammation. Complaints of discomfort in the lower abdomen and increased urination are evidence of the spread of infection to the urinary organs.

When making a diagnosis, an examination of the vagina and laboratory tests of discharge are performed.

Treatment of thrush

The task of treating vaginal candidiasis is to suppress the development of the infection and eliminate the causes that caused it.

The complex of medical measures includes:

• Appointment of antifungal drugs (tablets or suppositories) for intravaginal use.
• Therapy with antiseptic preparations for disinfection and cleansing of the vagina from pathogenic microorganisms.
• A temporary ban on the use of contraceptives, antibiotics and other drugs that destroy beneficial vaginal microorganisms and thereby contribute to the development of thrush.
• Therapy of existing diseases that have a negative impact on the level of immunity.

What is Livarol

Livarol is an antifungal drug in the form of vaginal suppositories, designed to eliminate vaginal infections:

• Therapy for acute, chronic or recurrent thrush
• Prevention of fungal infections in patients who have undergone treatment with antibiotics or other drugs that lower immunity and affect the state of the vaginal microflora.

The therapeutic substance of vaginal suppositories is ketoconazole, an imidazole derivative. Depending on the concentration, it has a fungicidal or fungistatic effect. After penetration into the cellular organism of the fungus, it suppresses the production of vital substances of the pathogen. Under the influence of drugs, the synthesis of ergosterol, triglycides and other compounds stops. The resulting deficiency makes it impossible for the formation of new cells, filaments and colonies of the fungus, which leads to the death of the pathogen. As a result, the infectious process is on the decline.

Ketoconazole affects dermatophytes, molds and other fungi. But most importantly, it suppresses candidal pathogens - the culprits of vaginal infection.

How to apply candles

How to use vaginal suppositories for thrush should be determined by the doctor individually for each patient. Usually one suppository per day is prescribed, an increase in procedures is possible according to indications. It is not recommended to change the dosage of the drug on your own.

The suppository is administered in the supine position to the maximum depth. Under the influence of human heat, the remedy will melt and turn into a thick mass that will cover the walls of the female organ. To prevent the product from leaking out, it is not recommended to get up after the procedure. In any case, doctors advise not to rise for 1.5-2 hours after the administration of the drug. In order not to spoil the bedding and minimize inconvenience, it is recommended to use sanitary pads.

The standard treatment regimen for thrush with Livarol is 5 days, with a severe or advanced form of infection, the gynecologist can extend the treatment for another 5 days. In addition, depending on the diagnosis, other drugs may be prescribed.

The treatment course should not be interrupted at the first symptoms of remission, as untreated thrush will return or become chronic. It will be more difficult to get rid of it, and the developed complications will cause serious damage to the body.

A stumbling block for many women is the issue of treatment during menstruation. Doctors do not advise interrupting treatment during menstruation. The medicine does not affect either the cycle or the volume of released blood. Moreover, antifungal suppositories have a healing effect on the mucous membranes of the vagina.

intimate question

Treatment of infectious diseases of the reproductive system often involves the rejection of sexual intercourse. There is no such requirement for Livarol. Gynecologists allow intimacy, but with one condition - you can have sex only before the medical procedure. After applying the candle, this is not recommended.

Otherwise, for the sexual partner, this may result in an allergic reaction to the drug - hyperemia of the penis.

Cause of Discharge Complaints

The main complaints about Livarol are copious discharge after suppositories. They can be white, pinkish or sandy. Most women are frightened, considering this a side effect or an exacerbation of the disease. Therefore, often the appearance of incomprehensible secretions provokes them to early refusal of treatment.

As gynecologists explain, what comes out of Livarol is a normal phenomenon associated with the characteristics of the drug. After dissolution in the vagina and penetration into the epithelial tissue, the multiplied microorganisms are suppressed. The “leakage”, which women so often complain about, is facilitated by the substances contained in the candles. They melt under the influence of human heat and create the effect of a bath. Penetrate themselves and simultaneously deliver ketoconazole to all parts and cells of the vaginal walls. And after the end of the therapeutic action, they leave the body along with the fungi and their metabolic products.

Complaints about discharge in the form of white sand are most often explained simply - these are the remains of a melted suppository. It is necessary to be alert if blood clots appear in the discharge. In this case, you should not postpone the visit to the doctor, contact him as soon as possible.

However, it should be noted that not all women experience copious discharge after suppositories. Due to the characteristics of the body, for each woman, the effect after candles manifests itself in different ways.

Who should not be treated with Livarol

Like any medication, Livarol has contraindications. Candles should not be used for:

• The presence of individual hypersensitivity of the body to the constituent components
• 1st trimester of pregnancy
• Children under 12 years of age.

The drug is approved for the treatment of thrush in pregnant women in the 2nd and 3rd trimesters. But in this case, the question of the use of Livarol should be decided by the gynecologist. The risks to the fetus at these times are minimal. The danger lies in the long-term use of suppositories, as the risk of developing allergic reactions of the body increases, which can adversely affect the health of the unborn child.

Although there is no strict ban on treatment with Livarol suppositories for nursing women, they should take into account that if an allergic reaction follows, it may adversely affect the composition or taste of milk. This is especially important to consider if long-term treatment is ahead. Therefore, the question of the use of suppositories during lactation is best agreed with the doctor.

If a woman has damage to the vagina, it is not recommended to use candles. First you need to achieve complete healing of open wounds, and only after that proceed with antifungal therapy.

What are the side effects

Due to the fact that Livarol suppositories are used for local treatment, the active substance of the drug ketoconazole practically does not pass into the body. Therefore, it does not enter the bloodstream and does not cause a systemic effect. All side effects of the antifungal drug are associated with the reaction of the female organ.

During the course of Livarol, the development of undesirable manifestations is not excluded:

• Severe itching and burning
• Redness or swelling of the vagina
• Pain in the vagina
• Rashes on the skin in the perineum
• Headaches, dizziness (in isolated cases).

More serious reactions (anaphylaxis) are extremely rare. Mostly occur when non-compliance with contraindications to the drug.

If any uncharacteristic symptoms appear after using the suppository, you should consult a gynecologist.

Pink discharge that may appear after the procedure is most likely associated with latent erosion. The components of the suppository irritate the blood vessels, and the discharge becomes stained. If this symptom appears, you need to consult a doctor to adjust further treatment.

Livarol vaginal suppositories are considered a good remedy for thrush. They not only eliminate its symptoms, but also relieve the causes of the disease - a fungal infection. But for therapy to be successful, it must take place only as directed by a doctor. Ignorance of the causes of the disease or incorrect definition of infection during self-treatment contributes to the transition of thrush into a chronic form. Getting rid of it will be much harder.

Thrush in women (urogenital candidiasis) is a common occurrence.

The pathology is characterized by fungal origin and has nothing to do with sexually transmitted diseases. At the same time, active candidal fungus causes discomfort to women and complicates gynecological diseases. It is also transmitted to the sexual partner if the sexual life is conducted without a condom.

It is necessary to start treating vaginal candidiasis as soon as possible, using effective topical agents. Often gynecologists prescribe Livarol suppositories - an effective fungicidal drug that is suitable for women of any age, pregnant and lactating mothers.

Livarol: composition and pharmacological properties

In Livarol suppositories, the composition is based on such an active substance as ketoconazole. Auxiliary ingredients are butylhydroxyanisole and the base for vaginal suppositories. Medicinal units are packed in contour cells. Each carton contains 5 or 10 cone-shaped suppositories. The color of the drug is white, yellow or pinkish.

The drug has fungicidal and fungistatic properties. This means that the active substance simultaneously inhibits the vital processes of the pathogen, destroys the structure of its body and provokes death. Useful microflora Livarol does not affect.

Livarol is able to suppress the activity of streptococci and staphylococci, which cause mixed infections and inflammatory processes in the pelvic organs. The use of suppositories in this case provides a complex effect and avoids treatment with a large number of medicines.

Why prescribe candles

The drug in question is effective against any microorganisms. If you have heard about Livarol suppositories, but do not know exactly what they are prescribed for, we recommend that you study the main indications for the use of this remedy.

When Livarol is prescribed:

• Vaginal candidiasis.
• Urogenital dysbacteriosis.
• Therapy of mild and recurrent forms of thrush.
• Prevention of fungal infections in the field of gynecology, the development of which is associated with weakened immunity.
• Support for the body after antibacterial and chemical therapy, which led to a disorder in the vaginal biocenosis.
• Mixed fungal infections provoked by staphylococci and streptococci.

At an early stage of thrush with mild pain and burning sensation when urinating, Livarol suppositories are prescribed for use within 1 to 3 days. Deep into the vagina, suppositories are administered in the supine position. It is more convenient to do the procedures before going to bed so that the melted candle does not leak out. A cloth napkin or panty liner will help protect linen from getting dirty.

The acute form of thrush is treated with the drug for 3 to 5 days. Progressive candidiasis is manifested by symptoms such as:

To improve the condition, suppositories are administered at night, following the recommendations from the instructions.

Chronic thrush with Livarol is treated for 10 days according to the scheme 1 suppository per day. A long course completely cleanses the genital tract from a fungal infection and restores the bacterial balance of the vagina.

Instruction

Livarol for children

Livarol suppositories are not prescribed for girls under 12 years of age. Upon reaching the age of 12 - 15 years, the drug is used according to indications.

During pregnancy

Pregnant women can use Livarol only as directed by a doctor. The first trimester is a contraindication to the treatment of thrush with Livarol during pregnancy. Another contraindication to the use of suppositories, doctors call individual intolerance to the components of the drug.

Doctors explain the prohibition of the use of Livarol during pregnancy by the fact that a tiny fraction of the active substance of suppositories enters the body of the expectant mother. Despite a slight concentration in the blood, ketoconazole can cause allergic reactions and have a toxic effect on the fetus, which is at the stage of formation of organs and tissues.

Analogues

Livarol practically does not cause side effects. Only in too sensitive patients can candles cause irritation of the vaginal mucosa. An allergic reaction is manifested by increased itching, swelling and redness of the tissues of the inguinal zone. The skin may react to the drug with hives or an itchy allergic rash.

In such cases, candles are canceled and more gentle analogues are selected:

• Sebozol.
• Ginezol.
• Nizoral.
• Mycozoral.
• Lomeksin.
• Pimafucin.
• Nystatin.
• Fluomizin.
• Macmirror.
• Primafungin.

A similar therapeutic effect is provided by candles Flagin, Sertaconazole, Ornisid, Candide (synonyms of Livarol).

How much does the drug cost

Each planimetric pack of Livarol is designed for 5 suppositories. The cost of five suppositories varies between 400 - 500 rubles. Accordingly, the price of 10 pcs. candles Livarola will be twice as large. In Ukrainian pharmacies, Livarol is sold at a price of 65 - 140 hryvnia. In Belarus, the cost of the drug ranges from 120 to 190 thousand rubles.

What are the advantages of Livarol against the background of other therapeutic intravaginal suppositories?

The main advantage of the drug is the content of a powerful fungicidal substance ketoconazole. It blocks the synthesis of a protein important for the structure of the mycelium and prevents the emergence of new pathogens.

Given that candidiasis develops under the influence of various factors, there is always a reason to buy Livarol. Thrush is provoked by diabetes mellitus, hormonal changes (including during pregnancy), infectious diseases of a chronic nature, antibiotic therapy and unprotected sexual intercourse. But the most important factor is the weakening of the immune system. Therefore, it is necessary to take care of health and prevent the body from losing resistance to pathogens.

During the period of application of Livarol, it is important not to interrupt the treatment and bring it to the end. If the drug is prescribed for a long time, and the unpleasant symptoms disappeared earlier, the course should be continued until the doctor cancels the therapy. This will avoid recurrence of thrush and prevent the transformation of the acute stage into a chronic one.

An important point in the fight against thrush is the treatment of both sexual partners. Intimate life for the duration of therapy is recommended to be canceled, and it is better not to use barrier contraceptives, since the drug reduces their effectiveness.

Also, a woman is advised to wear underwear made of breathable fabric (preferably cotton and without lace) and review the diet. The menu should be dominated by dairy and plant foods, fresh vegetables and fruits. From flour and sweet carbohydrate products must be abandoned completely or at least limit their consumption. Sweets negatively affect the vaginal environment and the composition of the microflora.

With frequent recurrences of thrush, women should regularly take a smear both during therapy and as the course ends. This approach will help to understand whether the drug copes with its functions and consider replacing it with a more effective analogue.

Registration number:

Active substance:

Dosage form:

Compound:

1 vaginal suppository contains:

active substance: ketoconazole 400 mg;

Excipients: butylhydroxyanisole;

base for suppositories: macrogol 1500 (polyethylene oxide 1500), macrogol 400 (polyethylene oxide 400) - a sufficient amount to obtain a suppository weighing 3.0 g.

Description:

Suppositories white, white with a yellowish or grayish, or with a creamy tinge of color, torpedo-shaped. Surface marbling is allowed.

Pharmacotherapeutic group:

Pharmacodynamics:

Active substance -
ketoconazole, an imidazoledioxolane derivative. It has a fungicidal and fungostatic effect on dermatophytes ( Trichophyton spp., Epidermophyton floccosum, microsporum spp. ) and yeast ( Candida spp., Pityrosporum spp.). The mechanism of action is to inhibit the biosynthesis of ergosterol and change the lipid composition of the fungal membrane.

The drug is active against staphylococci and streptococci.

Pharmacokinetics:

Systemic absorption with intravaginal use is negligible.

Indications for use

Treatment of acute and chronic recurrent vaginal candidiasis.

Prevention of the occurrence of fungal infections of the vagina with reduced body resistance and against the background of treatment with antibacterial agents and other drugs that disrupt the normal microflora of the vagina.

Contraindications

Hypersensitivity to the components of the drug.

Pregnancy (I trimester).

Carefully:

Pregnancy (II-III trimester), lactation, children under 12 years of age.

Pregnancy and lactation:

Having previously released the suppository from the contour packaging, it is injected deep into the vagina in the supine position, 1 suppository per day for 3-5 days, depending on the course of the disease. In chronic candidiasis, 1 suppository is used for 10 days.

Side effect

Hyperemia and irritation of the vaginal mucosa, vaginal itching.

Allergic reactions: skin rash, urticaria.

Overdose:

When using Livarol® vaginal suppositories 400 mg, negative interactions with other drugs are unknown and should not be expected, since the resorption capacity of ketoconazole is low.

Special instructions:

In rare cases, allergic reactions (hyperemia of the penis) are possible in the sexual partner.

Influence on the ability to drive a vehicle:

Suppositories vaginal 400 mg.

Package:

5 pieces are placed in a blister pack.

1 or 2 blisters, together with instructions for use, are placed in a cardboard box.

Storage conditions:

In a dry, dark place at a temperature not exceeding 25°C.

In a place inaccessible to children.

Best before date:

Do not use after the expiration date.

Conditions for dispensing from pharmacies:

Registration certificate holder:

Candles Livarol is an antifungal remedy that acts directly on the affected areas of the mucous membrane of the vulva and vagina. The drug is almost not absorbed into the blood, which means that it cannot adversely affect other body systems.

The active ingredient in Livarol is ketoconazole. Ketoconazole has a fungicidal and fungistatic effect, and also has an inhibitory effect on yeast-like fungi of the genus Candida, streptococci and staphylococci.

Livarol has fungicidal and fungistatic activity against dermatophytes, yeast fungi, dimorphic fungi and eumycetes. It is also active against staphylococci and streptococci. The mechanism of action is to inhibit the synthesis of ergosterol and change the lipid composition of the membrane.

Livarol instructions for use

The international name is Ketoconazole (Ketoconazole).
The trade name is Livarole.

Forms of release and composition

Vaginal suppositories: ketoconazole 400 mg;
The active substance is ketoconazole, an imidazoledioxolane derivative.
Excipients: butylated hydroxyanisole, polyethylene oxide 1500, polyethylene oxide 400;
Blisters contour packs: 5 or 10 pcs. packaged.

Pharmacological group

Antifungal agent.

pharmachologic effect

• antifungal;
• antimicrobial.

Indications for use

Fungal infections caused by susceptible pathogens: mycoses of the gastrointestinal tract, mycoses of the genital organs, dermatomycosis, onychomycosis. Systemic fungal infections. Prevention of fungal infections in patients with an increased risk of their development.

• Blastomycosis
• Histoplasmosis
• Candidiasis
• Candidiasis of the vulva and vagina
• Candidiasis of the skin and nails
• Candidiasis in other locations
• Candidiasis of other urogenital localizations
• candida meningitis
• Candidal stomatitis
• Pulmonary candidiasis
• Paracoccidioidomycosis
• Mycosis of the beard and head
• Mycosis of the hands
• Mycosis of nails
• Mycosis stop
• Mycosis of the trunk
• Sporotrichosis
• Epidermophytosis inguinal
• Dermatophytosis

Dosing regimen

• With dermatomycosis and multi-colored lichen, 200-400 mg / day are prescribed for 2-8 weeks.
• With onychomycosis - 200-400 mg / day for 3-12 months until clinical and mycological recovery.
• With systemic mycoses, 200-400 mg / day are prescribed for 2 weeks, then 200 mg for 4-6 weeks until complete recovery.
• For vaginal candidiasis, 400 mg (1 suppository) per day is administered intravaginally. within 3-5 days.

If necessary, the drug can be administered orally and intravaginally.

Children weighing more than 30 kg are prescribed in the same doses as adults. Children weighing less than 30 kg - 4-8 mg / kg of weight. The tablets should be taken with meals.

Side effects

In rare cases: nausea, vomiting, diarrhea, headache, dizziness, insomnia, photophobia, paresthesia, thrombocytopenia, exanthema. Very rarely - hair loss, allergic reactions (urticaria, skin rash, gynecomastia, decreased libido, oligospermia, arthralgia, fever.

Contraindications

Hypersensitivity, hepatic and / or renal failure, pregnancy, lactation.

Pregnancy and lactation

The drug is contraindicated in the first trimester of pregnancy. When using the drug in the 2nd and 3rd trimesters of pregnancy and during lactation, caution should be exercised.

Interaction

With simultaneous appointment with antacids, anticholinergics and H2-histamine blockers, the absorption of orally taken ketoconazole is reduced.

special instructions

During treatment, it is necessary to regularly monitor the picture of peripheral blood, the functional state of the liver and kidneys. If the treatment of skin lesions was carried out with glucocorticosteroids, then ketoconazole is prescribed no earlier than 2 weeks after their cancellation.

Terms and conditions of storage

The drug should be stored out of the reach of children, dry, dark place at a temperature not exceeding 25°C.

Best before date

Vacation from pharmacies

Without a doctor's prescription.

Livarol's analogs

• Ketoconazole
• Mycozoral

Reviews about Livarol

A very good drug. For quite a long time I lived with this, I didn’t particularly betray this strong significance, but recently the thrush has only intensified, the doctor prescribed livarol suppositories. After taking the first candle, I immediately felt the effect, and on the third day everything went away.

I didn't get thrush during my pregnancy. Nothing helped, neither suppositories nor creams, the doctor prescribed livarol suppositories for three days. So he said that they say it is not recommended for pregnant women, but then you can’t tolerate thrush either, it’s harmful to me and the baby, these candles helped me. In just three days, the thrush passed and did not return, the baby is healthy, and I, too, everything is fine.

The thrush appeared suddenly. She has been gone for a long time, but here is a present for the New Year. I made an appointment with the doctor the same day. Swab taken (as expected). But confirmed that 100 percent thrush. Has written out Livarol. The drug was unfamiliar to me. I was upset that the treatment with candles would drag on for an incomprehensible amount. But to my surprise and joy, Livarol began to act instantly. In the morning I woke up, went to the shower and there was practically no more discharge, and the scabies disappeared altogether. Today is the 5th day, I will put the last candle for the night, but it is already clear that the thrush has passed.

A very good tool. Appointed by a doctor. I completed the course (the doctor also advised taking it for 3 months, 5 days a month). Helped after the first 5 days of applications. Great candles and they are reasonably priced. Therefore, I highly recommend to all those who are faced with such a problem. But before using it is still advisable to consult a doctor.

I was also pleased that when using Livarol, life gets better almost from the first candle. In principle, this is understandable: the local action is faster than that of a tablet - as long as this tablet still reaches. The main thing is not to rejoice ahead of time and not stop the course, you need to deliver it to the end in order to finish off the candida.

And I treated thrush during pregnancy with Livarol. She endured until the 13th week (of course she tried to treat with pimafucin, but there was no result). And how it became possible so immediately the gynecologist prescribed Livarol. For 5 days, the thrush was gone and there were no relapses. Before giving birth, they didn’t even do sanitation. Everything was clean.

Livarol saved me when I was breastfeeding my baby. When feeding in general, you can’t drink an extra pill - the health of the child is more expensive. I decided to take local medicines. The gynecologist advised Livarol. It is indicated during pregnancy and lactation. I had heard of it before, but it was the first time I had used it in my own experience. I liked the drug - an effective and fast-acting remedy. After the first candle it became easier. The general course of treatment is 5 days.

I had thrush during pregnancy and when I was breastfeeding. The gynecologist in both cases prescribed Livarol for 5 days. The drug is quite familiar to me (I treated them with thrush even before pregnancy). Handled the infection perfectly with no extra help.

We are all different and different drugs help us. My friend treats thrush with clotrinazole all her life and helps her. It makes me itch even more. I can't light more than one candle. Livarol candles fit me perfectly. After the first candle, everything calms down inside (I mean itching and burning). I also put one or two candles and the thrush disappears completely. I found my remedy for thrush - livarol.

I was prescribed livarol for the treatment of chronic persistent thrush - it's terrible when it repeats every month before menstruation !!! For a long time and various means were treated. Clotrimazole helped at one time, but then the result was not very good either. Yes, and there the treatment is complex, to be honest, it bothered me to use both vaginal tablets and cream. I wanted one thing. I went to a private clinic to see a gynecologist. That's where the doctor offered me a whole scheme of treatment with livarol. For me it was really new. First, it was prescribed for treatment, and then for prevention. I don’t remember how long everything went together, both treatment and prevention, the main thing is that now I don’t have thrush.

I used Livarol when I was preparing for pregnancy. I went through all the tests for latent infections, everything was ok, except for elevated cocci and candidiasis against their background. The course was of 10 suppositories, after the gynecologist said that everything was fine and you can proceed. Right now we are working with my husband on this.

Good afternoon! I was also prescribed Livarol suppositories for thrush. I put down as many as two packs of 5 pieces first, then 10, and did not see any result, I was disappointed. And before that, Klion-D vaginal tablets were also prescribed and there was no effect in the same way. Now Pimafucin candles have already been prescribed, you can also Terzhinan, I don’t even know if it’s worth buying them, just wasting them, money wasted. But health is more important than both the baby and your own !!! Perhaps it will help. I also heard about Polygynax candles, they contain three active components at once, perhaps they will be effective. All the same, you need to somehow be treated before childbirth, and make your life easier and, God forbid, not infect the baby. This is the most important thing for our babies to be born healthy!!! Health to all future mothers!

I encountered thrush for the first time when feeding my second child, I don’t know what happened, but it suddenly came out. I put five days - one package was enough. It’s good that it is so effective that you don’t have to drink anything inside, as you yourself understand, you don’t really drink anything while feeding.

Thrush in women (urogenital candidiasis) is a common occurrence.

Pathology is characterized by fungal origin and has nothing to do with sexually transmitted diseases. At the same time, active candidal fungus causes discomfort to women and complicates gynecological diseases. It is also transmitted to the sexual partner if the sexual life is conducted without a condom.

It is necessary to start treating vaginal candidiasis as soon as possible, using effective topical agents. Often gynecologists prescribe Livarol suppositories - an effective fungicidal drug that is suitable for women of any age, pregnant and lactating mothers.

Livarol: composition and pharmacological properties

In Livarol suppositories, the composition is based on such an active substance as ketoconazole. Auxiliary ingredients are butylhydroxyanisole and the base for vaginal suppositories. Medicinal units are packed in contour cells. Each carton contains 5 or 10 cone-shaped suppositories. The color of the drug is white, yellow or pinkish.

The drug has fungicidal and fungistatic properties. This means that the active substance simultaneously inhibits the vital processes of the pathogen, destroys the structure of its body and provokes death. Useful microflora Livarol does not affect.

Livarol is able to suppress the activity of streptococci and staphylococci, which cause mixed infections and inflammatory processes in the pelvic organs. The use of suppositories in this case provides a complex effect and avoids treatment with a large number of medicines.

Why prescribe candles

The drug in question is effective against any microorganisms. If you have heard about Livarol suppositories, but do not know exactly what they are prescribed for, we recommend that you study the main indications for the use of this remedy.

When Livarol is prescribed:

• Vaginal candidiasis.
• Urogenital dysbacteriosis.
• Therapy of mild and recurrent forms of thrush.
• Prevention of fungal infections in the field of gynecology, the development of which is associated with weakened immunity.
• Support for the body after antibacterial and chemical therapy, which led to a disorder in the vaginal biocenosis.
• Mixed fungal infections caused by staphylococci and streptococci.

At an early stage of thrush with mild pain and burning sensation when urinating, Livarol suppositories are prescribed for use within 1 to 3 days. Deep into the vagina, suppositories are administered in the supine position. It is more convenient to do the procedures before going to bed so that the melted candle does not leak out. A cloth napkin or panty liner will help protect linen from getting dirty.

The acute form of thrush is treated with the drug for 3 to 5 days. Progressive candidiasis is manifested by symptoms such as:

To improve the condition, suppositories are administered at night, following the recommendations from the instructions.

Chronic thrush with Livarol is treated for 10 days according to the scheme 1 suppository per day. A long course completely cleanses the genital tract from a fungal infection and restores the bacterial balance of the vagina.

Instruction

Livarol for children

Livarol suppositories are not prescribed for girls under 12 years of age. Upon reaching the age of 12 - 15 years, the drug is used according to indications.

During pregnancy

Pregnant women can use Livarol only as directed by a doctor. The first trimester is a contraindication to the treatment of thrush with Livarol during pregnancy. Another contraindication to the use of suppositories, doctors call individual intolerance to the components of the drug.

Doctors explain the prohibition of the use of Livarol during pregnancy by the fact that a tiny fraction of the active substance of suppositories enters the body of the expectant mother. Despite a slight concentration in the blood, ketoconazole can cause allergic reactions and have a toxic effect on the fetus, which is at the stage of formation of organs and tissues.

Analogues

Livarol practically does not cause side effects. Only in too sensitive patients can candles cause irritation of the vaginal mucosa. An allergic reaction is manifested by increased itching, swelling and redness of the tissues of the inguinal zone. The skin may react to the drug with hives or an itchy allergic rash.

In such cases, candles are canceled and more gentle analogues are selected:

• Sebozol.
• Ginezol.
• Nizoral.
• Mycozoral.
• Lomeksin.
• Pimafucin.
• Nystatin.
• Fluomizin.
• Macmirror.
• Primafungin.

A similar therapeutic effect is provided by candles Flagin, Sertaconazole, Ornisid, Candide (synonyms of Livarol).

How much does the drug cost

Each planimetric pack of Livarol is designed for 5 suppositories. The cost of five suppositories varies between 400 - 500 rubles. Accordingly, the price of 10 pcs. candles Livarola will be twice as large. In Ukrainian pharmacies, Livarol is sold at a price of 65 - 140 hryvnia. In Belarus, the cost of the drug ranges from 120 to 190 thousand rubles.

What are the advantages of Livarol against the background of other therapeutic intravaginal suppositories?

The main advantage of the drug is the content of a powerful fungicidal substance ketoconazole. It blocks the synthesis of a protein important for the structure of the mycelium and prevents the emergence of new pathogens.

Given that candidiasis develops under the influence of various factors, there is always a reason to buy Livarol. Thrush is provoked by diabetes mellitus, hormonal changes (including during pregnancy), infectious diseases of a chronic nature, antibiotic therapy and unprotected sexual intercourse. But the most important factor is the weakening of the immune system. Therefore, it is necessary to take care of health and prevent the body from losing resistance to pathogens.

During the period of application of Livarol, it is important not to interrupt the treatment and bring it to the end. If the drug is prescribed for a long time, and the unpleasant symptoms disappeared earlier, the course should be continued until the doctor cancels the therapy. This will avoid recurrence of thrush and prevent the transformation of the acute stage into a chronic one.

An important point in the fight against thrush is the treatment of both sexual partners. Intimate life for the duration of therapy is recommended to be canceled, and it is better not to use barrier contraceptives, since the drug reduces their effectiveness.

Also, a woman is advised to wear underwear made of breathable fabric (preferably cotton and without lace) and review the diet. The menu should be dominated by dairy and vegetable foods, fresh vegetables and fruits. From flour and sweet carbohydrate products must be abandoned completely or at least limit their consumption. Sweets negatively affect the vaginal environment and the composition of the microflora.

With frequent recurrences of thrush, women should regularly take a smear both during therapy and as the course ends. This approach will help to understand whether the drug copes with its functions and consider replacing it with a more effective analogue.

The female body has a well-coordinated system that performs its necessary functions day after day. However, under the influence of various negative factors, failures can occur, which ultimately cause the appearance of unpleasant infectious diseases.

One of these often include fungal infections of the genital organs. If they are not treated on time, they can become more severe and cause serious complications.

In these cases, the drug Livarol is often prescribed. This tool helps to quickly eliminate various problems of a gynecological nature, but first you need to consider in detail the description thereof.

Description of the drug, release form, composition

Livarol is a medicine that has an antimicrobial effect. This drug is for topical use. The main purpose of this medication is to suppress a fungal infection that affects the mucous membranes of the vulva and vagina.

When used, the constituent components of this remedy are almost not absorbed into the blood, so Livarol does not adversely affect other body systems.

The active ingredient in Livarol is ketoconazole. This element has a fungicidal and fungistatic effect.

In addition, it has a depressing effect on yeast-like fungi of the genus Candida, streptococci and staphylococci. Its mechanical effect is to inhibit the synthesis of ergosterol, as well as to change the lipid composition of the membrane.

In addition to the active component, the composition contains auxiliary elements:

• butylhydroxyanisole;
• polyethylene oxide 1500;
• polyethylene oxide 400.

Livarol is produced in the form of suppositories, they are also called suppositories, which are intended for vaginal use. Candles are packed in contour packs of 5 pieces. 1-2 packs are placed in a carton box.

Indications and contraindications

The main indications of the drug Livarol include:

1. Vaginal candidiasis in acute and chronic form;
2. Preventive treatment of fungal infections of the female reproductive system, which are caused by a decrease in the body's resistance;
3. The period after the use of antibacterial and other similar agents that have a destructive effect on the natural microflora of the vagina;
4. Violations of the natural microflora of the vagina, which occurs for various reasons, including the period of bearing a child.

But it should be borne in mind that this remedy has contraindications, of course, there are not so many of them, but they are.

• it is not recommended to use the medicine in the presence of an allergic reaction to the constituent components;
• in the presence of hypersensitivity of individual intolerance;
• should not be used during the first 12 weeks of bearing a child. It is in the first trimester that the laying of all organs and systems of the embryo is observed, and the use of medication with ketoconazole can adversely affect its development.

There are also indications in which Livarol is used with extreme caution:

Livarol candles: instructions for use

Before you start using the medication, be sure to carefully consider its description and scheme of application. Usually the dose and period of application depends on the symptoms, the severity of the disease.

• in the presence of acute vaginal candidiasis (thrush), it is recommended to insert one suppository into the vagina with a dosage of the active ingredient of 400 mg. Entered once a day. The period of treatment therapy should be 5 days;
• during the treatment of vaginal candidiasis with a chronic and recurrent form, 1 suppository is inserted into the vagina per day. The course of application is 10 days;
• with preventive therapy of candidiasis, 1 candle should be inserted every day. The application period should be 5 days. You need to start using immediately after the end of menstruation. If necessary, the course can be repeated every month.

According to the instructions, candles are best administered in the evening before bedtime. If they are used in the morning, the remedy may leak from the vagina when walking, running or other active movements.

After the drug is administered, it is necessary to lie down for about an hour and a half, so that the active components are absorbed into the mucous layer of the genital organs.

How to use during pregnancy and lactation

For this reason, the use of drugs can adversely affect the development of the baby.

In the rest of the period of bearing a child, Livarol candles are allowed to be used, but not for a long time. With prolonged use, side effects and allergic reactions may occur.

During breastfeeding, when using Livarol suppositories, care must be taken. It is worth using within 5-7 days, but no more. With long-term use of this drug, unpleasant symptoms may occur.

Side effects, overdose

Before using suppositories, you should pay attention to some side effects that may occur when using them, but they are very rare.

Sometimes the following side effects may occur:

1. Hyperemia or redness of the skin of the perineum and vaginal mucosa;
2. Burning sensation;
3. Feeling of itching;
4. In rare cases, allergic reactions of a local nature are manifested - the appearance of a rash on the skin, its itching and redness, symptoms of urticaria.

If you experience severe side effects, you should stop using the drug Livarol. There are no data on overdose.

Special instructions, interaction

When using Livarol suppositories, the following special instructions should be observed:

• it is recommended to use the candle immediately after removing it from the package, do not hold it in your hands for too long or damage it;
• if suddenly, after removing the candle, it fell to the floor, then it cannot be used, because it becomes contaminated with various pathogenic bacteria;
• not recommended for use after the expiration date;
• in order to prevent the recurrence of the disease, simultaneous therapy of the sexual partner is required;
• when prescribing medication to adolescents under the age of 12, special care must be taken;
• the drug does not affect the speed of psychomotor reactions and does not reduce the level of concentration.

When using Livarol with other drugs, no undesirable interaction is detected. It is unlikely due to the reduced resorption capacity of ketoconazole.

The price of the drug

The average price of the drug depends on the number of suppositories in the package. In the pharmacies of the capital, this remedy can be purchased quite inexpensively:

1. A package with 5 candles can be purchased for 405-416 rubles;
2. A package with 10 suppositories is sold from 590 to 600 rubles.

Analogues

Sometimes pharmacies do not always have Livarol on sale, then you can use its analogues:

• Candide in the form of a cream 1% - price from 250 rubles;
• Candide B6 in the form of candles. The cost of a package with 6 candles can be purchased for 80 rubles;
• Metrogyl Plus vaginal cream. The price of this drug is 250 rubles per pack;
• Ketoconazole. This remedy is available in the form of a suppository ointment. Ointment costs from 60 to 100 rubles, candles - 400 rubles;
• Lomeksin. The cost of a package with 2 candles is from 360 rubles, the cream costs from 490 rubles.