Biogenic stimulants classification. The main drugs are biogenic stimulants
Biogenic stimulants- a complex of biologically active substances of animal and vegetable origin, which have a versatile stimulating effect on various systems and organs of the macroorganism. Biogenic stimulants are formed in phyto- and zooorganisms in response to a number of adverse external influences (temperature, light and X-ray exposure, exposure to toxic agents, etc.).
Environmental factors that cause the appearance of biogenic stimulants can be varied. Of the factors contributing to the formation of biogenic stimulants in animal tissues separated from the body, their preservation at a relatively low temperature (2-4 ° C above zero) is the most studied, and in relation to plant leaves, their preservation in the dark. Other factors (chemical agents, elevated temperature, radiant energy, etc.) continue to be studied. Of the factors contributing to the emergence of biogenic stimulants in the whole animal organism, traumatic injuries, exposure to X-ray and ultraviolet rays, and the effect of toxic doses of certain substances have been studied. The formation of biogenic stimulants in whole plant organisms has been established when they are irradiated with x-rays. In addition, the occurrence of biogenic stimulants is also possible under certain physiological conditions, for example, during muscular work.
Obtaining biogenic stimulants is carried out by infusion of raw materials with cold or hot water or steam distillation (biogenic stimulants are highly soluble in water and heat resistant).
The chemical nature of biogenic stimulants is not well understood. As a rule, they are a complex complex of substances. The qualitative and quantitative composition of biogenic stimulators in tissue preparations is not constant and partly depends on the specifics of the metabolism of the tissue itself. Dicarboxylic hydroxy acids of the aliphatic series, aromatic acids of large molecular weight, amino acids, humic compounds, phospholipids, vitamins, microelements have the highest biological activity.
The biological activity of biogenic stimulants is evaluated by their ability to activate metabolic processes in the body. There are biogenic stimulants obtained from plants and animal tissues, and biogenic stimulants isolated from therapeutic mud (peloids) and peat.
Pharmacodynamics of biogenic stimulants is determined by an increase in the intensity of metabolic, incl. bioenergy, processes, as a result of the influence on the activity of a number of enzymes. It is believed that activation occurs due to the formation of complexes of enzymes with biogenic stimulators, as well as due to a shift in the optimal zones of enzyme action. Biogenic stimulants enhance the function of the hypothalamus - pituitary - adrenal cortex, thyroid, pancreas, gonads.
For preparations containing biogenic stimulants of plant origin, include liquid aloe extract (for injection and for oral administration), tablets, juice and aloe liniment obtained from canned (kept at a low temperature in the dark) fresh or dried aloe leaves; Kalanchoe juice (fresh leaves and green part of the stems); biosed (water extract from canned fresh stonecrop herb).
drugs biogenic stimulants of animal origin are the suspension and extract of the placenta for injection, obtained from the human placenta preserved in the cold, as well as polybiolin (a preparation from donor, retroplacental and placental human blood serum).
Preparations of biogenic stimulants from pelloids include FiBS for injections (a preparation from the distillation of estuary mud containing cinnamic acid and coumarins), peloid distillate (a product of distillation of estuary mud), peloidin (an extract from silt therapeutic mud), gumizol (0.01% solution of humic fractions acids of the Haapsalu sea mud in an isotonic solution of sodium chloride), peat (a product of distillation of peat from certain deposits) and Vulnuzan (an ointment containing an extract from the mother liquors of the Pomorie salt lakes in Bulgaria).
Preparations of biogenic stimulants are apyrogenic, do not accumulate in the body, do not have anaphylactogenic, allergenic, histamine-like properties, do not cause addiction and sensitization.
The action of most drugs of biogenic stimulants is nonspecific. They are prescribed to stimulate metabolic and regenerative processes, as well as to increase the body's resistance.
Biogenic stimulants are most widely used in ophthalmology for blepharitis, vitreous opacity, conjunctivitis, diseases of the cornea and retina, neuritis and optic nerve atrophy, progressive myopia, etc. placenta).
In surgery, preparations of biogenic stimulants (aloe liniment, biosed, peloidin, Kalanchoe juice, Vulnuzan) are used to accelerate the consolidation of bone fractures, in the treatment of purulent wounds, trophic ulcers, burns, and to accelerate the resorption of scars and adhesions.
In the clinic of internal diseases in the complex therapy of bronchial asthma, gastric ulcer and duodenal ulcer, gastritis, gastroenteritis, colitis, rheumatoid arthritis, arthrosis, etc., extracts, aloe juice and liniment, biosed, peloidin, suspension and placenta extract are used.
In dermatology, in the treatment of inflammatory skin diseases, lupus, radiation damage to the skin, chronic eczema, aloe juice and liniment are used.
In neurology, in chronic and subacute radiculitis, plexitis, myalgia, FiBS, peloid distillate, peat, gumizol, placenta extract, polybiolin are used.
In gynecology, for subacute and chronic inflammatory diseases of the internal genital organs, peloidin, placenta extract, polybiolin are prescribed.
In otorhinolaryngology with adhesive otitis, cochlear neuritis, chronic inflammatory diseases of the nose, pharynx, larynx, trachea can be used. B.'s preparations with. (extracts, tablets and liniment of aloe, biosed, Kalanchoe juice, FiBS, gumizol, peloidin, peat).
In dentistry, with periodontal disease and chronic gingivitis, biosed, gumizol and peat are prescribed. Besides, B. with. can be used in geriatric practice, because they have a positive effect on the functional state of the aging organism.
Preparations of biogenic stimulants are used topically, orally and parenterally, as a rule, in combination with specific drugs, for example, in combination with antibiotics, synthetic chemotherapeutic drugs, etc. They are contraindicated in acute febrile and severe cardiovascular diseases, cerebrovascular accidents, acute disorders functions of the gastrointestinal tract, active form of tuberculosis, malignant neoplasms, psychosis, pregnancy.
List of main biogenic stimulants , their doses, methods of application, forms of release and storage conditions are given below.
BIOSED (Biosedum) is prescribed subcutaneously or intramuscularly daily for adults, 1-2 ml(up to 3-4 ml) per day, children under 5 years - 0.2 - 0.3 ml, older than 5 years - 0.5 - 1 each ml 1 time per day, usually for 20 - 30 (if necessary, up to 45) days. Under the conjunctiva injected 0.3 - 0.5 ml within 10 - 25 days, in the form of eye drops - 1 - 2 drops 4 - 6 times a day. In the form of applications on the gums and electrophoresis, apply 3 - 5 - 7 min daily for 10 - 20 days. Release form: ampoules 1 ml.
PLACENTA SUSPENSION FOR INJECTIONS (Suspensio Placentae pro injectionibus) is prescribed subcutaneously in 2 doses ml(previously injected with a 0.5% solution of novocaine) 1 time in 7-10 days, for a course of 3-4 injections. Release form: ampoules of 2 ml.
VULNUSAN (Vulnusan) is applied in a thin layer directly on the wound or on gauze applied to the affected surface. In the early days, the ointment is used daily, after the disappearance of inflammation - every other day. Release form: in tubes of 45 G.
GUMISOL (Gumisolum). Made from Estonian sea mud. It is a 0.01% solution of the humic acid fraction in an isotonic sodium chloride solution. The preparation contains up to 33-40% of humic acids, which have a significant anti-inflammatory effect. At the same time, the preparation contains biologically active substances of an oligodynamic nature. Transparent sterile liquid with a yellowish tint, salty taste, neutral reaction. It is used for chronic and subacute radiculitis, plexitis, neuralgia, inactive rheumatoid arthritis, chronic diseases of the middle ear and paranasal sinuses and other diseases. Humisol is prescribed intramuscularly, 1 ml in the first 2-3 days and in the future with good tolerance - 2 ml 1 time per day for 20-30 days. With pronounced local signs of the disease, electrophoresis with gumizol is used (10-20-30 min daily or every other day for 8-20 days). Release form: ampoules of 2 and 10 ml.
ALOE LINIMENT (Linimentum Aloes) is applied in a thin layer on the affected surface 2-3 times a day and covered with a gauze napkin. Release form: 30-50 G. in orange glass bottles.
PELOIDIN (Peloidinum) is prescribed orally for 40-50 ml 2 times a day (morning and evening) heated for 1-2 h before meals or the same period after meals for 4-6 weeks, in the form of enemas (for colitis) 2 times a day, 100 ml within 10-15 days. Outwardly, the drug is prescribed for washing purulent wounds and for wetting dressings. Release form: 500 ml in glass bottles.
It is an extract from silt therapeutic mud containing, in addition to biogenic stimulants, a complex salt complex (sodium, potassium, calcium, magnesium, chlorides, sulfates, carbonates, phosphates, bromides, iodides). To obtain the drug, the mud is loaded into a ceramic tank and filled with water at the rate of 280 kg of mud 720 liters of water, at the same time 6.68 kg of sodium chloride is added per 1000 kg of the mixture to make the solution isotonic. The stirrer is turned on and infused for 3-6 days at room temperature until the filtered extract sample has: density 1.008-1.010, pH 7.4-7.8, dry residue 12-16 hum and chlorides 11.5-13, 5 g/l. The liquid is allowed to settle, after which it is siphoned and filtered twice, the second time through finely porous sterile plate filters. The dehydrated filtrate is heated for 1 ! / I h at a temperature of 60-70 ° C and in aseptic conditions poured into flasks of 0.5 liters. The drug is a clear liquid that must be stored in a dark, cool place. It is used for bacillary dysentery, colitis, peptic ulcer of the stomach and duodenum, gastritis, colpitis and some diseases of the uterus, as well as in the treatment of purulent wounds.
PELOIDODISTILLATE FOR INJECTIONS (Peloidodestillatum pro injectionibus) is prescribed subcutaneously, 1 ml 1 time per day for 1 month. Release form: ampoules 1 ml.
POLIBIOLIN (Polybiolinum) before use, the contents of the vial are dissolved in 5 ml 0.25-0.5% novocaine solution; administered intramuscularly daily for 5 ml solution within 8-10 days. Release form: in vials of 0.5 G.
ALOE LEAF EXTRACT (Extractum Aloes). It is prepared from the leaves of a tree-like aloe (agave) - Aloe arborescens Milli, cultivated in the Transcaucasus and Central Asia. In more northern latitudes, aloe is grown in greenhouses or bright, warm rooms. Plants not younger than 2 years are used. To make the extract, cut off the lower leaves as necessary, leaving the top of the immature young leaves intact, as well as 3-4 upper leaves. Cuts must be made without damaging the plants, then leaves can be cut from each for many years. Cut leaves are left for 10-12 days in the dark at a temperature of 4-8°C. During the canning process, the leaves may turn slightly yellow. Browned and blackened leaves are washed with water and dried. Then the cloves and yellowed ends are removed from the leaves, after which they are cut and rubbed. The resulting slurry is poured with three times the amount of distilled water and infused at room temperature for 2 hours. Then the contents of the tincture are heated and boiled for 3-2 minutes (to coagulate proteins), after which it is filtered. The filtrate is allowed to cool, its volume is measured and the oxidizability determined by titration with 0.01 N. potassium permanganate solution in the presence of sulfuric acid. According to the analysis, the filtrate is diluted with such an amount of water that its oxidizability is equal to 1500 mg of oxygen per 1 liter of filtrate. Sodium chloride (7 g per 1 L) is added to the filtrate, boiled again for 2 minutes and filtered. The clear extract is poured into vials (for internal use) or ampoules, which are sterilized in an autoclave at 120°C for an hour. In the manufacture of aloe extract, the use of iron equipment is unacceptable. The drug is a clear liquid from light yellow to yellowish red; pH 5.0-5.6. Store in a dark cool place. Shelf life 6 months. It is used for a number of eye diseases, conjunctivitis, blepharitis, trachoma, clouding of the vitreous body, etc., as well as for gastric and duodenal ulcers, bronchial asthma, etc. .
Liquid aloe extract (Extractum Aloes fluidum) is prescribed orally 1 teaspoon 3 times a day for 30-45 days. Release form: in vials of 100 ml.
ALOE EXTRACT LIQUID FOR INJECTIONS (Extractum Aloes fluidum pro injectionibus) is administered subcutaneously daily to adults, 1 ml(maximum daily dose 3-4 ml), children under 5 years old - 0.2-0.3 ml, older than 5 years - 0.5 each ml per day. The course of treatment is 30-50 injections. Release form: ampoules 1 ml.
ALOE JUICE (Succus Aloes) is prescribed orally 1 teaspoon 2-3 times a day for 20-30 min before meals for 15-30 days, as well as externally in the form of lotions or irrigation. Release form: in vials of 100 ml.
ALOE TABLETS (Tabulettae Aloes) are prescribed orally 1 tablet 3-4 times a day for 15-20 min before meals for 1 month. Release form: coated tablets containing 0.05 G. aloe leaf.
KALANCHOE JUICE (Succus Kalanchoes) is applied externally by irrigation (1-3 ml juice) wounds or ulcers with a syringe and subsequent application of a gauze bandage, richly moistened with juice, for 15-20 days, as well as in the form of applications on the mucous membranes of the oral cavity 3-4 times a day. Release form: ampoules of 10 ml and vials of 100 ml. Before drinking, the juice is kept at room temperature for at least 30 min.
PEAT (Torfotum) Distillation of peat. Transparent colorless sterile liquid without taste, with a characteristic smell of peat; pH 6.0-7.0. Indications for use are the same as for FIBS. It is used in the form of subcutaneous or subconjunctival injections. Produced in ampoules of 1 ml, injected subcutaneously 1 ml daily for 30-45 days, under the conjunctiva - 0.2 each ml every other day for 1 month. Release form: ampoules 1 ml.
PLACENTA EXTRACT FOR INJECTIONS (Extractum Placentae pro injectionibus) is prescribed subcutaneously, 1 ml daily or every other day for 20-30 days. Release form: ampoules 1 ml.
FIBS FOR INJECTIONS (Fibs pro injectionibus) is used subcutaneously, 1 ml 1 per day. The course of treatment is 30-35 injections. Release form: ampoules 1 ml. FiBS. It is a distillate from firth mud, in which cinnamic acid and coumarin are dissolved, the latter, according to the authors of the preparation (V.P. Filatov, Z.A. Bieber and V.V. Skorodinskaya), should be classified as biogenic stimulants. Initially, the process proceeds as with peloid distillate, then 0.3-0.4 g of cinnamic acid, 0.1 g of coumarin and 7.5 g of sodium chloride are added for each 1 liter of distillation. The dissolution is carried out by heating under reflux. After dissolution, it is filtered, poured into ampoules and sterilized. The drug is a clear colorless liquid with a pH of 4.6-5. Stored in a cool dark place. It is used in the same cases as peloid distillate.
All preparations of biogenic stimulants are stored in a place protected from light. Some of them (aloe liniment, Kalanchoe juice) are stored at a temperature not exceeding 10 °, and polybiolin - at 10-25 °.
pharmachologic effect
Biogenic stimulants enhance metabolic processes and regeneration, have a general tonic and anti-inflammatory effect. Promote the resorption of inflammatory infiltrates, reduce pain; increase the detoxifying function of the liver and have immunostimulating properties (splenin); stabilize cell membranes, inhibit lipid peroxidation, stimulate hepomoesis (ceruloplasmin, erythrophosphatide, erygem); improve metabolic processes in violation of cerebral and peripheral circulation (actovegin); regulate the functions of the endocrine system (epithalamin); stimulate leukopoiesis during radiation therapy and chemotherapy of tumors (zymosan); have a positive effect on prostatitis, benign hyperplasia and the initial phase of prostate adenoma (cernilton, trianol, raveron); used to treat patients with multiple sclerosis (propermil).
Classification of biogenic stimulants
The entire large group of biogenic stimulants can be classified according to their origin:
herbal products;
means of animal and human origin;
mineral products.
Biogenic stimulants of plant origin:
Preparations containing biogenic stimulants of plant origin include: liquid aloe extract (for injection and oral administration), tablets, juice and aloe liniment obtained from canned (kept at a low temperature in the dark) fresh or dried aloe leaves. Aloe leaf extract (Extractum Aloes) is obtained from biostimulated (canned) leaves of treelike aloe - Aloe arborescens Milli. For biostimulation, aloe leaves are kept in the dark at 4-8°C for 10-12 days. Then they are washed, dried, cloves, yellowed ends are removed and crushed on rollers. The resulting slurry is poured with 3 times the amount of distilled water and infused at room temperature. After 2 hours, the contents of the tincture are heated and boiled for 2-3 minutes (to coagulate proteins), after which it is filtered. The filtrate is allowed to cool, its volume is measured and the oxidizability determined by titration with 0.01 N. potassium permanganate solution in the presence of sulfuric acid. In accordance with the analysis data, the filtrate is diluted with such an amount of water that its oxidizability is equal to 1500 mg of oxygen per 1 liter of filtrate.
Sodium chloride (7 g per 1 L) is added to the filtrate, boiled again for 2 minutes and filtered. A transparent extract is poured into vials (for internal use) or ampoules, which are sterilized in an autoclave at 120 ° C for an hour. In the manufacture of aloe extract, the use of iron equipment is unacceptable. The drug is a clear liquid from light yellow to yellowish red; pH 5.0-5.6. Store in a dark cool place. Shelf life 6 months. It is used for a number of eye diseases, conjunctivitis, blepharitis, trachoma, clouding of the vitreous body, etc., as well as for gastric and duodenal ulcers, bronchial asthma, etc.
Kalanchoe juice (Succus Kalanchoes). Juice from fresh leaves and the green part of the stems of the Kalanchoe pinnate plant, fam. crassian. Yellow liquid with an orange tint, aromatic odor, transparent or slightly opalescent, with a fine suspension, easily broken when shaken. Kalanchoe juice has a local anti-inflammatory effect, helps cleanse wounds from necrotic tissues, and stimulates their healing. Applied externally in the treatment of trophic ulcers, non-healing wounds, burns, bedsores, nipple cracks in nursing mothers, aphthous stomatitis, gingivitis, etc. The wound or ulcer is irrigated with juice (1-3 ml) using a syringe and a gauze bandage is applied (4- 5 layers), richly moistened with juice. The bandage is changed first daily, then every other day. Once a day, additionally moisten the lower layers of the bandage with juice (removing the upper layers). The average duration of the course of treatment is 15-20 days. Kalanchoe juice is applied to the mucous membranes of the oral cavity in the form of an application 3-4 times a day. Apply several times a day to cracked nipples. The drug is usually well tolerated. In the event of a burning sensation in the wound, Kalanchoe juice can be diluted with an equal amount of 1-2% novocaine solution. Release form: in ampoules of 10 ml or in vials of 100 ml in a package of 10 ampoules or vials. Storage: at a temperature not higher than + 10 "C. Before drinking, the juice is kept at room temperature for at least 30 minutes. In dental practice, the juice is heated in a water bath to a temperature of + 37 "C before use.
Biosedum (Biosedum) water extract from biostimulated fresh herb stonecrop (Sedum maximum L.Suter) which is crushed, poured with 10 times the amount of water and heated at a temperature of 95-98 ° C for 10 minutes. The operation is repeated twice. The extract and juice are combined, squeezed, settled, filtered. Biosed is a clear liquid, light yellow in color with a slight peculiar odor. It is poured into ampoules of 1 ml, sterilized at a temperature of 120 ° C for 30 minutes and stored in a place protected from light.
AKGOVEGIN (Actovegin)
Released from protein (deproteinized) extract (hemoderivat) from the blood of calves. Contains 1 ml of 40 mg of dry matter.
Pharmachologic effect. Actovegin activates cellular metabolism (metabolism) by increasing the transport and accumulation of glucose and oxygen, enhancing their intracellular utilization. These processes lead to an acceleration of the metabolism of ATP (adenosine triphosphoric acid) and an increase in the energy resources of the cell. Under conditions that limit the normal functions of energy metabolism (hypoxia / insufficient supply of oxygen to the tissue or impaired absorption /, lack of substrate) and with increased energy consumption (healing, regeneration / tissue repair /), actovegin stimulates the energy processes of functional metabolism (the process of metabolism in body) and anabolism (the process of assimilation of substances by the body). The secondary effect is increased blood supply.
Indications for use. Insufficiency of cerebral circulation, ischemic stroke (insufficient supply of oxygen to the brain tissue due to acute cerebrovascular accident); traumatic brain injury; violations of peripheral circulation (arterial, venous); angiopathy (impaired vascular tone); trophic disorders (malnutrition of the skin) with varicose veins of the lower extremities (changes in the veins characterized by an uneven increase in their lumen with the formation of a protrusion of the wall due to a violation of the function of their valvular apparatus); ulcers of various origins; bedsores (tissue necrosis caused by prolonged pressure on them due to lying down); burns; prevention and treatment of radiation injuries. Damage to the cornea (the transparent membrane of the eye) and sclera (the opaque membrane of the eye): corneal burn (acids, alkali, lime); corneal ulcers of various origins; keratitis (inflammation of the cornea), including after transplantation (transplantation) of the cornea; corneal abrasions in patients with contact lenses; prevention of lesions during the selection of contact lenses in patients with dystrophic processes in the cornea (for the use of eye jelly), as well as to accelerate the healing of trophic ulcers (slowly healing skin defects), bedsores (tissue necrosis caused by prolonged pressure on them due to lying), burns, radiation damage to the skin, etc.
Method of application and dose. Doses and route of administration depend on the type and severity of the course of the disease. The drug is administered orally, parenterally (bypassing the digestive tract) and topically.
Inside designate 1-2 pills 3 times a day before meals. Dragee is not chewed, washed down with a small amount of water.
For intravenous or intra-arterial administration, depending on the severity of the disease, the initial dose is 10-20 ml. Then administer 5 ml intravenously
slowly or intramuscularly, once a day, daily or several times a week. Intravenously, 250 ml of solution for infusion is administered intravenously at a rate of 2-3 ml per minute 1 time per day, daily or several times a week. You can also use 10, 20 or 50 ml of injection diluted in 200-300 ml of glucose or saline. In total, the course of treatment is 10-20 infusions. It is not recommended to add other drugs to the infusion solution.
Parenteral administration of actovegin should be carried out with caution due to the possibility of developing an anaphylactic (allergic) reaction. Trial injections are recommended, and it is necessary to provide conditions for emergency therapy. No more than 5 ml can be administered intravenously, since the solution has hypertonic properties (the osmotic pressure of the solution is higher than the osmotic pressure of the blood). With intravenous use of the drug, it is recommended to monitor the indicators of water and electrolyte metabolism.
Local application. The gel is prescribed for the cleansing and treatment of open wounds and ulcers. For burns and radiation injuries, the gel is applied to the skin with a thin layer. In the treatment of ulcers, the gel is applied to the skin in a thicker layer and covered with a compress with actovegin ointment in order to prevent sticking to the wound. Bandages are changed once a week; with strongly weeping ulcers - several times a day.
The cream is used to improve wound healing, as well as weeping wounds. Use after the formation of bedsores and the prevention of radiation injuries.
The ointment is applied in a thin layer to the skin. It is used for long-term treatment of wounds and ulcers in order to accelerate their epithelization (healing) after gel or cream therapy. For the prevention of bedsores, the ointment must be applied to the appropriate areas of the skin. To prevent radiation damage to the skin, the ointment should be applied after irradiation or in between sessions.
Eye gel, 1 drop of gel is squeezed directly from the tube into the affected eye. Apply 2-3 times a day. After opening the package, the eye gel can be used for no more than 4 weeks.
Side effect. Allergic reactions: urticaria, a feeling of a rush of blood, sweating, fever. Itching, burning in the area of application of the gel, ointment or cream; when using the eye gel - lacrimation, injection of the sclera (redness of the sclera).
Contraindications. Hypersensitivity to the drug. Prescribe the drug with caution during pregnancy. During lactation, the use of actovegin is undesirable.
Release form. Dragee forte in a package of 100 pieces. Solution for injection in ampoules of 2.5 and! 0 ml (1 ml - 40 mg). Solution for infusion 10% and 20% with saline in 250 ml vials. Gel 20% in tubes of 20 g. Cream 5% in tubes of 20 g. Ointment 5% in tubes of 20 g. Eye gel 20% in tubes of 5 g.
Storage conditions. In a dry place at a temperature not higher than +8 "C.
ALOE COATED TABLETS (Tabulettae Aloes obductae)
Pharmachologic effect. It has a stimulating effect on the body, accelerates the processes of regeneration (recovery) of tissues.
Indications for use. Applied for the purpose of non-specific therapy in the complex treatment of progressive myopia and myopic chorioretinitis (eye disease with decreased vision).
Method of application and dose. Dose for adults - 1 tablet 3-4 times a day 15-20 minutes before meals. The course of treatment is an average of 1 month. After 3-6 months. the course of treatment is repeated if necessary.
Side effect. Not marked.
Contraindications. Not identified.
Release form. Film-coated tablets containing 0.05 g of crushed canned aloe tree leaf, in a package of 20 pieces.
Storage conditions. In a dry, cool place.
ALOE LINIMENT (Linimentum Aloes)
Aloe emulsion.
Pharmachologic effect. Biogenic stimulant.
Indications for use. For burns and for the prevention and treatment of skin lesions during radiation therapy.
Method of application and dose. Liniment 2-3 times a day is applied in a thin layer on the affected surface and covered with a napkin.
Release form. In bottles of 50 g. Composition: aloe tree juice (Canned) - 78 g, castor oil - 10.1 g, emulsifier No. 1 - 10.1 g, eucalyptus oil - 0.1 g, sorbic acid -0.2 g , sodium carboxymethylcellulose - 1.5 g.
Storage conditions. In a place protected from light at a temperature not exceeding 10 ° C. Freezing of the liniment is not allowed.
ALOE WITH IRON SYRUP (Sirupus Aloes cum fenro)
Pharmachologic effect. Hemopoiesis stimulator.
Indications for use. Applied with hypochromic anemia (decrease in hemoglobin in the blood).
Method of application and dose. Assign "/ 2-1 teaspoon to the reception in "/ 4 glasses of water 3 times a day; the duration of the course of treatment is on average 15-30 days.
Release form. In vials of 100 g. Composition: a solution of ferrous chloride containing 20% iron - 135 g, diluted hydrochloric acid - 15 g, citric acid - 4 g, syrup from aloe tree juice - up to 1000 g.
Storage conditions. In a cool place.
ALOE JUICE (Succus Aloes)
Pharmachologic effect. Biogenic stimulant.
Indications for use. With gastritis (inflammation of the stomach), gastroenteritis (inflammation of the mucous membranes of the stomach and small intestine), enterocolitis (inflammation of the small and large intestine), constipation, burns, purulent wounds, etc.
Method of application and dose. Inside, a teaspoon 2-3 times a day for half an hour before meals: in the treatment of purulent wounds, burns, inflammatory skin diseases externally.
Release form. In vials of 100 ml. Ingredients: juice from freshly harvested aloe leaves - 80 ml, ethyl alcohol 95% - 20 ml, chlorobutanol hydrate - 0.5 g.
Storage conditions.
ALOE EXTRACT LIQUID (Extractum Aloes fluidum)
Aqueous extract from crushed canned aloe leaves.
Pharmachologic effect. Biogenic stimulant.
Indications for use. Used for a number of eye diseases (progressive myopia, myopic chorioretinitis /eye disease with decreased visual acuity/, blepharitis /inflammation of the edges of the eyelids/, conjunctivitis /inflammation of the outer shell of the eye/, keratitis /inflammation of the cornea/, iritis /inflammation of the iris/, clouding vitreous / transparent mass filling the cavity of the eyeball / etc.), as well as gastric ulcer and duodenal ulcer and other diseases.
Method of application and dose. A teaspoon 3 times a day for 30-45 days. The course of treatment is repeated 3-4 times a year.
Release form. In vials of 100 ml.
Storage conditions. In a dark cool place.
ALOE EXTRACT LIQUID FOR INJECTIONS (Extractum Aloes fluidum pro injectionibus)
Pharmachologic effect. Biogenic stimulant.
Indications for use. Eye diseases (progressive myopia, myopic chorioretinitis / eye disease with reduced vision /, blepharitis / inflammation of the eyelid margins /, conjunctivitis / inflammation of the outer shell of the eye /, keratitis / inflammation of the cornea /, iritis / inflammation of the iris /, clouding of the vitreous / transparent mass filling the cavity of the eyeball / etc.), peptic ulcer of the stomach and duodenum, bronchial asthma, etc.
Method of application and dose. Subcutaneously daily, 1 ml (maximum daily dose - 3-4 ml), children under 5 years old - 0.2-0.3 ml, over 5 years old - 0.5 ml. The course of treatment (15-50 days) after 2-3 months. may be repeated.
With bronchial asthma, 1.0-1.5 ml for 10-15 days, then 1 time in 2 days, a total of 30-35 injections.
Contraindications. Severe cardiovascular diseases, hypertension (persistent rise in blood pressure), pregnancy after 7 months, acute gastrointestinal disorders, advanced nephrosonephritis (kidney disease).
Release Form^
Storage conditions. In a dark, cool place.
Aloe leaf extract is also part of the drug Holaflux.
APILAC (Apilacum)
Dry matter of native royal jelly.
Pharmachologic effect. Biogenic stimulant.
Indications for use. Hypotrophy (malnutrition) and anorexia (lack of appetite) in infants and young children, hypotension (low blood pressure), malnutrition in convalescents (recovering), neurotic disorders, lactation disorders (milk production) in the postpartum period, seborrhea (skin disease, associated with dysfunction of the sebaceous glands) of the skin of the face.
Method of application and dose. Children from 0.0025 g to 0.005 g in the form of suppositories 3 times a day for 7-15 days. Adults sublingually (under the tongue) 0.01 g 3 times a day for 10-15 days; with seborrhea of the skin of the face creams containing 0.6% of the drug.
Side effect. With increased individual sensitivity, sleep disturbances.
Contraindications. Addison's disease (decreased adrenal function), idiosyncrasy (hereditary hypersensitivity) to the drug.
Release form. Powder; tablets of 0.01 g in a package of 25 pieces; candles in a package of 10 pieces of 0.005 g and 0.01 g.
Storage conditions. In a dry, dark place at a temperature not exceeding +8 °C.
BEFUNGIN (Befunginum)
Synonyms: Innotin.
Pharmachologic effect. Biogenic stimulant.
Indications for use. As a symptomatic (improving well-being, but not affecting the immediate cause of the disease) remedy in patients with malignant tumors of various localization, as well as in chronic gastritis (inflammation of the stomach) and dyskinesia (impaired mobility) of the gastrointestinal tract with a predominance of atony (loss of tone) .
Method of application and dose. Assign the drug inside: 2 teaspoons of the drug are diluted with 150 ml of heated boiled water and taken 1 tablespoon 3 times a day half an hour before meals. Treatment is carried out by long courses (3-5 months) with breaks between them of 7-10 days.
Side effect. With prolonged use, dyspeptic symptoms (digestive disorders) are possible.
Release form. In bottles of 100 g.
Storage conditions. In a cool, dark place.
BIOSED (Biossedum)
Aqueous extract from the herb stonecrop.
Pharmachologic effect. Biogenic stimulant.
Indications for use. As an adjuvant that stimulates metabolic processes and tissue regeneration (recovery) in ophthalmology (in eye practice), therapy, surgery and dentistry.
Method of application and dose. Intramuscularly daily 1-2 ml for 20-30 days. After 2-4 months. the course of treatment can be repeated. In ophthalmology, simultaneously administered subconjunctival (under the outer shell of the eye) 0.3-0.5 g for 10-25 days or in the form of installations (instillation) 2 drops 4-5 times a day, as well as by electrophoresis (method of administration medicinal substances through the intact mucous membrane by means of electric current) 3-7 minutes daily up to 20 procedures. In dentistry - applications (overlay) 1-2 times a day, injections into the gum tissue or electrophoresis.
Side effect. Local allergic reactions in young children.
Contraindications. Malignant neoplasms, gastritis (inflammation of the stomach) and peptic ulcer occurring with achilia (lack of secretion of hydrochloric acid and enzymes in the stomach).
Release form. Ampoules of 1 ml in a package of 10 pieces.
Storage conditions. In a dry, dark place at room temperature.
VULNUSAN (Vulnusan)
Pharmachologic effect. Helps cleanse and accelerate the healing of superficial purulent wounds, cracks (anus), etc.
Indications for use. As a means to stimulate metabolic processes. Treatment of wounds, varicose ulcers (expressions at the site of dilated veins of the extremities),
cracks in the rectum, on the heels, cracks in the nipples in women, etc.
Method of application and dose. Apply a thin layer directly to the wound or to gauze applied to the affected surface. In the early days, the ointment is applied daily, after the disappearance of inflammation - every other day.
Side effect. Soreness when applied to varicose ulcers; allergic reactions.
Contraindications. Hypersensitivity to the drug.
Release form. Ointment in tubes of 45 g. Composition: extract from the mother liquors of the Pomorie salt lakes in Bulgaria - 12 g, castor oil - 35 g, lanolin - 15 g, water - up to 100 ml.
Storage conditions. In a dry place protected from light.
HEMATOGEN (Haematogenum)
Preparation from defibrinated (devoid of fibrin) blood of slaughtered cattle.
Pharmachologic effect. It has antianemic (preventing the development of anemia - a decrease in hemoglobin in the blood) action.
Indications for use. Anemia, malnutrition.
Method of application and dose. Inside in tiles 1-2 shares per reception 2-3 times a day.
Side effect. Not marked.
Contraindications. Not identified.
Release form. In tiles of 50 g.
Storage conditions. In a dry, cool place.
GLUNAT (Glunatum)
Indications for use. It is used to accelerate reparative (restorative) processes in long-term non-healing lesions of the skin (trophic ulcers / slowly healing skin defects / etc.), as well as in gastric and duodenal ulcers. With pneumonia (pneumonia) and other diseases, it is used to stimulate the body's defenses.
Method of application and dose. Enter intramuscularly, starting with 1 ml, then increase the dose daily by 1 ml, bringing it to 10 ml, then gradually reduce the dose to the original (1 ml). In total, 5-20 injections are made. Courses of treatment can be repeated.
Contraindications. Injections are contraindicated in active forms of tuberculosis, tumors, thrombophlebitis (inflammation of the vein wall with their blockage), thrombosis (blockage of the vessel with a blood clot).
Release form. In ampoules of 1 and 5 ml in a package of 10 ampoules. Composition: human plasma or serum - 273 or 235 ml, respectively, sodium bicarbonate - 5.43 g, glucose - 27.3 g and water for injection up to 1000 ml.
Storage conditions. At a temperature not higher than +25 °C.
Kalanchoe juice (Kalanchoes succus)
Juice from fresh leaves and the green part of the stems of the Kalanchoe pinnate plant, fam. crassian.
Pharmachologic effect. Kalanchoe juice has a local anti-inflammatory effect, helps cleanse wounds from necrotic (dead) tissues, and stimulates their healing.
Indications for use. Applied externally in the treatment of trophic ulcers (slowly healing skin defects), non-healing wounds, burns, bedsores (tissue necrosis caused by prolonged pressure on them due to lying), cracked nipples in nursing
mothers, aphthous stomatitis (inflammation of the oral mucosa), gingivitis (inflammation of the gum mucosa), etc.
Method of application and dose. The wound or ulcer is irrigated with juice (1-3 ml) using a syringe and a gauze bandage (4-5 layers), richly moistened with juice, is applied. The bandage is changed first daily, then every other day. Once a day, additionally moisten the lower layers of the bandage with juice (removing the upper layers). The average duration of the course of treatment is 15-20 days. Kalanchoe juice is applied to the mucous membranes of the oral cavity in the form of an application (overlay) 3-4 times a day.
In dental practice, the juice is heated in a water bath to a temperature of +37 ° C before use.
For cracked nipples in nursing mothers, apply to the affected areas several times a day.
Side effect. The drug is usually well tolerated. In the event of a burning sensation in the wound, Kalanchoe juice can be diluted with an equal amount of 1-2% novocaine solution.
Release form. In ampoules of 10 ml or in vials of 100 ml in a package of 10 ampoules or vials.
Storage conditions. At a temperature not higher than +10°С. Before drinking, the juice is kept at room temperature for at least 30 minutes.
Calcipotriol (Calcipotriol)
Synonyms: Psorkutan.
Pharmachologic effect. Synthetic analogue of the most active metabolite (metabolite) of natural vitamin Da. It causes a dose-dependent inhibition of keratinocyte proliferation (an increase in the number of cells of the surface layer of the skin), significantly increased in patients with psoriasis and accelerates their morphological differentiation. It has a slight effect on the metabolism (exchange) of calcium in the body.
Indications for use. Psoriasis.
Method of application and dose. The ointment is applied in a thin layer to the affected areas of the skin 2 times a day. The maximum daily dose of the drug should not exceed 15 g, and the weekly dose should not exceed 100 g. Usually, the therapeutic effect develops within 1-2 weeks of treatment. The duration of the course of therapy does not exceed 6-8 weeks.
After applying the drug, wash your hands thoroughly.
Side effect. In rare cases, transient skin irritation may occur. When using the drug in large doses exceeding those recommended, hypercalcemia (an increase in the calcium content in the blood) is possible, which quickly disappears when the dose is reduced or the drug is discontinued.
Contraindications. Hypersensitivity to the drug. In children, use with caution. It is not recommended to use the drug during pregnancy. Do not use with topical salicylic acid preparations. It is not recommended to apply the drug on the skin of the face.
Release form. Ointment in tubes of 30 g, containing 1 g of 50 mcg of calcipotriol.
Storage conditions. In a cool place.
PELOIDIN (Peloidlnum)
Extract of silt therapeutic mud.
Pharmachologic effect. Biogenic stimulant.
Indications for use. Peptic ulcer of the stomach and duodenum, gastritis (inflammation of the stomach), colitis (inflammation of the large intestine), purulent wounds.
Method of application and dose. Inside, 40-50 ml 2 times a day (morning and evening) in a heated form 1-2 hours before
food or 1-2 hours after eating (small sips for several minutes), with colitis, it is prescribed as enemas 2 times a day, 100 ml with a catheter to a depth of 14-16 cm. The course of treatment for peptic ulcer is 4-6 weeks. , with colitis - 10-15 days. For purulent wounds, the drug is used for washing and wetting dressings.
Release form. In vials of 500 ml.
Storage conditions. In a cool, dark place.
Plasmol (Plasmolum)
A drug derived from human blood.
Pharmachologic effect. A biostimulant that has desensitizing (preventing or inhibiting allergic reactions) and analgesic (pain relieving) activity.
Indications for use. As a non-specific desensitizing and analgesic for neuralgia (pain that spreads along the nerve), neuritis (inflammation of the nerve), radiculitis and other diseases of the nervous system, accompanied by pain, as well as gastric and duodenal ulcers, bronchial asthma, chronic inflammatory processes , arthritis (inflammation of the joint).
Method of application and dose. 1 ml subcutaneously daily or every other day. The course of treatment - 10 injections.
Contraindications. Decompensation of cardiac activity (a sharp decrease in the pumping function of the heart), nephritis (inflammation of the kidney), endocarditis (inflammation of the internal cavities of the heart).
Release form. In ampoules of 1 ml in a package of 10 pieces.
Storage conditions. At a temperature not higher than +10 °C.
PLACENTA SUSPENSION (Suspensio placentae)
Suspension in an isotonic solution of sodium chloride in a 1: 2 dilution of finely divided placenta.
Pharmachologic effect. Biogenic stimulant.
Indications for use. Eye diseases (keratitis, corneal opacity, iritis, clouding of the vitreous body / transparent mass filling the cavity of the eyeball /) and other cases when the appointment of biogenic stimulants is indicated.
Method of application and dose. Subcutaneously, 2 ml (previously injected with a 0.5% solution of novocaine) every 7-10 days. For children, the dose is reduced according to age. The course of treatment (3-4 injections) can be repeated after 2-3 months.
Side effect. Sometimes, after the injection, subfebrile temperature (37-38 ° C), weakness, discomfort, slight leukocytosis (an increase in the number of leukocytes in the blood) are noted.
Contraindications. Tuberculous eye diseases, scrofulosis (enlarged lymph nodes), uncompensated glaucoma (increased intraocular pressure), severe kidney and cardiovascular diseases, pregnancy.
Release form. Ampoules of 2 ml in a package of 6 pieces.
Storage conditions. At room temperature.
PLACENTA EXTRACT (Extractum placentae)
Aqueous extract (extraction) from cold-preserved human placenta.
Pharmachologic effect. Biogenic stimulant.
Indications for use. Eye diseases (blepharitis, keratitis, etc.), myalgia (muscle pain), arthritis (inflammation of the joint), radiculitis, inflammatory diseases.
Method of application and dose. Subcutaneously, 1 ml daily or every other day.
Side effects and contraindications are the same as for placental suspension.
Release form. Ampoules of 1 ml in a package of 10 pieces.
Storage conditions. In a cool, dark place.
POLIBIOLIN (Polybiollnum)
A drug obtained from donor, retroplacental and placental blood serum (blood serum obtained from the placental space and placenta) of a person.
Pharmachologic effect. Belongs to the group of biostimulating drugs with a predominant anti-inflammatory effect; promotes the resorption of inflammatory infiltrates (seals), reducing pain.
Indications for use. It is used for adnexitis (inflammation of the uterine appendages), parametritis (inflammation of the periuterine spaces) and other chronic diseases of the female genital area, with fresh postoperative adhesions in the abdominal cavity, to prevent the development of adhesions, as well as for lumbosacral sciatica, plexitis (damage to the nerve plexus) , neuralgia (pain spreading along the course of the nerve). It is also sometimes prescribed for chronic "recurrent (repeating) furunculosis (multiple purulent inflammation of the skin).
Method of application and dose. To use the drug, the contents of the vial (0.5 g) are dissolved in 5 ml of a 0.25-0.5% solution of novocaine; administered intramuscularly daily, 5 ml of solution for 8-10 days. If necessary, the course of treatment is increased or repeated courses are carried out.
Contraindications. The drug is contraindicated in circulatory decompensation (inadequate blood supply to organs) and active forms of pulmonary tuberculosis.
Release form. In vials of 0.5 g.
Storage conditions. In a dry, dark place at a temperature of +10 to +25 °C.
PROPER-MIL (Proper-Mul)
The drug is a complex of saccharomyces fungi (Cryptococcus albidus, Candida tropicalis, Saccharomyces cerevisial).
Indications for use. Multiple sclerosis (a systemic disease of the sheaths of nerve cells).
Method of application and dose. Intravenously, daily, starting with 0.1 ml of a freshly prepared suspension (suspension of solid particles in a liquid), with a gradual increase in dose by 0.1 ml, and after a week by 0.2 ml and bringing to 2.5-3 ml. The course of treatment (30-40 days) after 3-4 months. may be repeated.
Before administration, dilute the contents of the vial in 5 ml of solvent. The resulting suspension has the form of a slightly opalescent suspension. Shake the suspension lightly before injection.
At the first injections, due to the small volume of the injected drug (0.1-0.2 ml, etc.), you should draw this amount from the vial with a small (insulin) syringe and, observing the rules of asepsis (sterility), add 2-3 ml 5% glucose solution; inject the resulting suspension into a vein. From the diluted drug remaining in the vial, an additional 0.5-1.0 ml can be administered intramuscularly. The unused part of the drug is poured; Do not store an opened vial.
Injections must be combined with therapeutic exercises, massage, etc.
p. 533), cocarboxylase, atriphos, prozerin or galantamine (see p. 89, 88), vitamins (Bi - see p. 414, Wb - see p. 412, Bi: - see p. 418, nicotine acid - see page 409). Cottage cheese, fish, oatmeal, beans, fresh vegetables and fruits should be added to the diet.
Release form. Ampoules with a capacity of 5 ml containing 10 mg of lyophilized (freeze-dried in a vacuum) drug, with a solvent (5% glucose solution) in a package of 20 pieces.
Storage conditions. In a place protected from light at a temperature not exceeding +10 "C.
PROPOLIS (Propolis)
Propolis (bee glue) is a waste product of bees. Used by bees to cover the walls of hives, strengthen honeycombs, etc.
Dense or sticky elastic-viscous mass of greenish-brown or dark brown color with a grayish tint, specific odor, bitter-burning taste. Almost insoluble in water, soluble in alcohol.
The composition of propolis includes a mixture of resins, wax, essential oils and other substances. Chemical analysis shows the presence in propolis of a number of natural compounds (flavones, flavanones, flavanols, derivatives of cinnamic acid, aetoxybetulinol, etc.) contained in the buds of trees (birch, poplar, etc.), from which bees collect sticky secretions.
Indications for use. In folk medicine, propolis is used to remove corns (applied in the form of a cake mixed with fat on the corn), in the treatment of wounds and burns (in the form of an ointment), for rinsing with inflammatory diseases of the mouth and throat (diluted alcohol solution), etc. There are data on the effectiveness of a 30% alcohol solution of propolis in certain skin and fungal diseases (pyoderma, eczema, etc.).
For medical use, propolis tincture, propoline tablets, propoceum ointment, proposol aerosol, propomizol aerosol are allowed.
PROPOLIS TINCTURE (Tincture Propolis!)
solution of propolis in 80% ethanol.
Indications for use. Microtrauma, superficial damage to the skin and mucous membranes, otitis media (inflammation of the ear cavity), pharyngitis (inflammation of the pharynx), tonsillitis (inflammation of the palatine tonsils / tonsils /), sinusitis (inflammation of the maxillary sinus), periodontal disease (anatomical tissues surrounding the root of the tooth ).
Method of application and dose. A tampon moistened with tincture is applied to the wounds 1-3 times a day. For otitis, 1-2 drops are instilled 3-4 times a day or a tampon is inserted for 1-2 minutes. Tonsils are lubricated 1-2 times a day for 7-10 days. In chronic sinusitis, the cavities are washed 2 times a day for 14 days (the tincture is mixed 1:10 with a solution of sodium chloride). In case of periodontal diseases, the tincture is injected on turundas (thin gauze swabs) into periodontal pockets (the space between the tooth root and surrounding tissues) for 5 minutes. For wounds on the mucous membrane in the oral cavity, tincture (15 ml per 1/2 cup of water) is used as a rinse 4-5 times a day for 3-4 days.
Side effect. Allergic reactions.
Contraindications. Hypersensitivity to the drug, eczema.
Release form. Tincture in dropper bottles of 25 and 50 ml.
Storage conditions. List B. In a dry, cool, dark place.
"PROPOMIZOL" AEROSOL (Aerosolum "Propomisolum")
A complex dosage form in an aerosol package (under nitrogen pressure) containing a propolis phenolic preparation (1%), eucalyptus oil, clove oil, stabilizer (tween-80), distilled water.
Indications for use. It is used as a local anti-inflammatory, disinfectant (destroying microbes) and local anesthetic in dental practice and in diseases of the upper respiratory tract (see aerosol "pro-ambassador").
Method of application and dose. Aerosol irrigate the inflamed area for 2 seconds 2-3 times a day for 7-10 days.
Side effect. When applying the aerosol, a burning sensation may occur.
Contraindications.
Release form. 30 g in glass aerosol cans with a protective polymer coating (with non-dosing valve).
Storage conditions. At temperatures from +5 to +25 ° C in a dry place.
"PROPOSOL" AEROSOL (Aerosolum "Proposolum")
Aerosol preparation containing: propolis - 6 g, glycerin - 14 g, ethyl alcohol 95% - 80 g and propellant (freon).
Indications for use. It is used as an anti-inflammatory, disinfectant (destroying microbes) and analgesic in dental practice: for catarrhal gingivitis (inflammation of the gum mucosa) and stomatitis (inflammation of the oral mucosa), aphthous and ulcerative stomatitis (inflammation with the formation of ulcers of the oral mucosa) , glossitis (inflammation of the pharynx) and other inflammatory diseases of the oral cavity.
Method of application and dose. Aerosol irrigate the inflamed area 2-3 times a day, and with a decrease in the inflammatory process 1-2 times a day until complete recovery (usually within 3-7 days).
Contraindications. The drug is contraindicated in persons with individual intolerance, allergic diseases and allergic reactions to bee products.
Release form. In aerosol cans with a valve device and a spray nozzle (50 g per bottle).
Storage conditions. At a temperature not lower than 0 ° C and not higher than +35 "C, away from fire and heating devices.
The packaging should be protected from impacts, drops, exposure to direct sunlight.
Biogenic stimulants- These are substances that enhance the natural processes of healing and tissue renewal, stimulate the body. Before using them, you should consult a doctor, as there are contraindications for them.
Biogenic stimulants used by official medicine include:
- herbal preparations - extracts of aloe, stonecrop, ginseng, eleutherococcus, magnolia vine, other plants, as well as honey and propolis
- animal products - placental suspension
- firth mud preparations - FiBS, peloid distillate, peloidin and others
- preparations from peat - peat
- mumiyo
Aloe tree- perennial herbaceous fleshy, succulent plant. Its leaves contain 8 essential amino acids, vitamins A, B 2 , B 6 , B 12 , C and E, folic acid and niacin, as well as calcium, sodium, iron, potassium, chromium, magnesium, manganese, copper and zinc.
Preparations from aloe juice improve digestion, have an anti-inflammatory effect and promote wound healing, strengthen teeth and gums. Used for gastritis, gastroenterocolitis, constipation, gastric ulcer, bronchial asthma and other chronic diseases. In the form of an ointment, they are used to heal burns.
Contraindicated in severe cardiovascular diseases, hypertension, pregnancy, acute gastrointestinal
disorders, severe nephronephritis.
"Root of Life" - ginseng. In the East, especially in China, ginseng is known as an all-healing remedy. The most valuable part is the roots. The weight of individual roots of a plant that has lived for more than 100 years can reach 200 grams. Decoctions, powders, alcohol tinctures are prepared from its root. They are prescribed as a tonic for hypotension, fatigue, fatigue, neurasthenia, as well as during the recovery period after serious illness, which is usually accompanied by severe weakness, a drop in pressure and cardiac activity.
Eleutherococcus senticosus its properties are equivalent to ginseng. It inspires vivacity, returns efficiency and cheerfulness. People call it the "devil's bush". The roots and leaves of the plant are used.
Unlike ginseng, Eleutherococcus preparations are effective at any time of the year. It has tonic properties, the ability to sharpen hearing, vision, increases mental and physical performance. All these properties appear 15 days after the start of the drug.
Biosed- aqueous extract from canned fresh herb sedum of a large family of Crassulaceae. It enhances the processes of metabolism and regeneration, has a general tonic and anti-inflammatory effect. It is used as an adjuvant to stimulate metabolic and regenerative processes in ophthalmic (burns of the cornea, fresh corneal opacities), dental (periodontal disease), surgical (acceleration of the consolidation of bone fractures, treatment of trophic and varicose ulcers of the lower leg) and therapeutic (peptic ulcer of the stomach and duodenum ) practice.
Apilak- a preparation made from the royal jelly of bees. It is prescribed for children and adults to improve appetite, to strengthen immunity, to increase milk production for nursing mothers, with hypotension.
Contraindications: allergy to honey, insufficiency of the adrenal cortex.
5012 0
Biosed(Biosedum).
pharmachologic effect: aqueous extract from the herb Stonecrop (Sedum maximum L. Surer) of the crassula family (Crassulaceae). It enhances the processes of metabolism and regeneration, has a general tonic and anti-inflammatory effect.
Indications: used in the complex therapy of inflammatory and degenerative periodontal diseases.
Mode of application: injected under the mucous membrane, in the region of the transitional fold, under the skin or intramuscularly. Adults appoint 1-2 ml (up to 3-4 ml) daily. The course of treatment is 20-30 injections. A second course is possible after 24 months.
Side effect: possible hyperemia, allergic reactions in the injection area.
Contraindications: do not use in patients with achilia, malignant neoplasms.
Release form: 1.2 ml ampoules.
Storage conditions
Glucosamine(glucosamine). Synonym: Dona.
pharmachologic effect: the active ingredient of the drug - glucosamine sulfate is a substance used in the body to synthesize the main substance of cartilage tissue - proteoglycans and hyaluronic acid of the synovial fluid. The drug compensates for the endogenous deficiency of glucosamine, stimulates the biosynthesis of proteoglycans, initiates the process of fixing sulfur in the synthesis of chondroitinsulfuric acid, increases the deposition of calcium in bone tissue, and helps to restore damaged cartilage tissue.
Indications: primary and secondary osteoarthritis of the temporomandibular joint.
Mode of application: inside - the contents of one packet of Don's preparation are dissolved in a glass of water, prescribed 1 time per day. The approximate course of treatment is 6 weeks, if necessary, the course of administration is repeated after 2 months.
Contraindications: individual intolerance to the drug, phenylketonuria.
Side effect: rarely - dyspeptic disorders, flatulence, diarrhea, constipation.
Interaction with other drugs: increases the absorption of tetracycline, reduces the absorption of oral penicillins and chloramphenicol. Can be used simultaneously with non-steroidal anti-inflammatory drugs, glucocorticoids.
Release form: Dona - dry substance for oral solution containing 1.5 g of glucosamine sulfate in 1 sachet (20 sachets per pack). Other Ingredients: Aspartame, Soritol, Carbovacs 4000, Citric Acid.
Storage conditions: in a cool dry place.
Peloid distillate(Peloidodistillatum).
pharmachologic effect: is a biogenic stimulant, a product of estuary mud distillation.
Indications, Mode of application: see FIBS.
Release form: 1 ml ampoules.
Storage conditions: in a place protected from light.
Plazmol(Plasmolum).
pharmachologic effect: a drug from human blood, has the properties of a biogenic stimulant and has an analgesic effect.
Indications: used for dystrophic changes in periodontal tissues, neuralgia, neuritis, accompanied by pain, sluggish chronic inflammatory processes in the maxillofacial region.
Mode of application: injected under the skin 1 ml daily or every other day. The course of treatment on average consists of 10 injections.
Contraindications: cardiac decompensation, nephritis, endocarditis, acute inflammation. It is not allowed to prescribe physiotherapeutic procedures simultaneously with the use of plasmol.
Release form: in ampoules of 1 ml.
Storage conditions: in a cool, dark place.
Propolis(Propolis).
pharmachologic effect: is a product of the vital activity of bees, contains vegetable resins, essential oils and wax, pollen, the secret of the salivary glands of bees, mineral elements, a number of natural compounds (flavones, flavonones, flavonols, cinnamic acid derivatives, etc.). It has antibacterial and antifungal, anti-inflammatory, analgesic effect; contributes to the acceleration of regeneration processes.
Indications: used in dentistry for the treatment of infectious and inflammatory lesions of the oral mucosa and lips, aphthous and ulcerative stomatitis, inflammatory diseases of periodontal tissues, glossitis, fusospirilosis.
Mode of application: the following preparations containing propolis are allowed for medical use: Proposol aerosol - a preparation containing (per 100 g) propolis 6 g, glycerin 14 g, ethyl alcohol (95%) 80 g and freon. Aerosol irrigate the affected area in the first days 2-3 times a day, after the elimination of acute inflammation - 1-2 times a day until complete recovery.
Release form: aerosol cans of 50 g; ointment "Propoceum" - contains 10% propolis extract. It is used topically for applications in aphthous and ulcerative stomatitis, ulcerative necrotic gingivitis, traumatic lesions of the oral mucosa and lips. Apply 1-2 times a day, the duration of treatment is 23 weeks.
Contraindications: allergic diseases, individual hypersensitivity to propolis.
Release form: in tubes of 30 and 50 g.
Storage conditions: in a cool place.
Kalanchoe juice(Succus Kalanchoes).
pharmachologic effect: Juice from the fresh leaves and green part of the stems of the Kalanchoe pinnate plant of the Crassulaceae family. It has a local anti-inflammatory property, helps cleanse wounds from necrotic tissues, and stimulates wound healing.
Indications: used for actively ongoing inflammatory reactions in periodontal tissues, ulcerative lesions of the oral mucosa of a bacterial nature, infected wounds, thermal and mechanical damage to the oral mucosa and lips.
Mode of application: appoint locally in the form of applications of the drug warmed up to 37 ° C on the affected area for 10-15 minutes 3-4 times a day. The duration of the course is 15 days. When applied to burn and erosive surfaces in the first days, the drug is diluted with an equal amount of 1-2% novocaine solution to reduce pain.
Release form: in ampoules of 10 ml, in vials of 100 ml.
Storage conditions: at a temperature not higher than +10°С.
vitreous body(Corpus vitreum).
pharmachologic effect: biogenic stimulator from the vitreous body of the eyes of cattle, has an analgesic effect, promotes the resorption of scar tissue, stimulates reparative osteogenesis.
Indications: used for chronic diseases of periodontal tissues, accompanied by destructive phenomena, parasthesia of the oral cavity, hyperesthesia of hard dental tissues; as an anesthetic for neuralgia; for softening and resorption of scar tissue.
Mode of application: administered 2 ml subcutaneously daily. The duration of the course for neuralgia is 8-10 days, for the treatment of periodontal diseases and cicatricial changes - 20-25 days.
Contraindications: infectious diseases, acute inflammatory processes, general exhaustion, nephritis, liver cirrhosis, heart failure, malignant tumors.
Release form: 2 ml ampoules.
Storage conditions: at room temperature.
FIBS for injections(FIBS pro injectionibus).
pharmachologic effect: is a biogenic stimulant from the distillation of firth mud, contains cinnamic acid and coumarins. It has a non-specific stimulating effect, promotes tissue regeneration.
Indications: used for sluggish inflammatory and dystrophic processes in periodontal tissues against the background of a decrease in the level of immune defense factors of the body.
Mode of application: administered under the mucous membrane in the transitional fold or under the skin, 1 ml of the drug daily. The course is prescribed 30-35 injections.
Contraindications: absolute Contraindications They are malignant neoplasms, hormonal disorders, allergic diseases and decompensated forms of diseases of internal organs. Not recommended for active ongoing inflammatory processes in the periodontium.
Release form: ampoules of 1 ml in a package of 10 pieces.
Storage conditions: in a place protected from light.
Khonsurid(Chonsuridum).
Active substance: preparation obtained from the trachea (hyaline cartilage) of cattle.
pharmachologic effect: contains chondroitin sulfuric acid, which is involved in the construction of the basic substance of connective tissue. Promotes the acceleration of reparative processes in sluggish inflammatory processes, long-term non-epithelializing wounds, stimulates reparative osteogenesis.
Indications: used for chronic inflammatory and degenerative periodontal diseases with severe tissue destruction occurring against the background of impaired immunological reactivity, long-term non-healing burns, traumatic lesions of the oral mucosa, to stimulate reparative osteogenesis after patchwork operations, resection of the root apex.
Mode of application: administered topically in the form of applications. To prepare the solution, the contents of the vial are diluted with 5-10 ml of a 0.5% solution of novocaine or isotonic sodium chloride solution. The drug can also be used to fill bone cavities after surgical methods for the treatment of periodontal diseases, resection of the root apex.
Contraindications: acute inflammatory processes in the area of the lesion, extensive tissue necrosis, excessive growth of granulations.
Release form: bottles of 0.05 and 0.1 g of sterile powder.
Storage conditions: in a dry, dark place at a temperature not exceeding + 20 ° C.
The dentist's guide to medicines
Edited by Honored Scientist of the Russian Federation, Academician of the Russian Academy of Medical Sciences, Professor Yu. D. Ignatov