Children's ACC - cough medicine. Instructions for use ACC

Syrup "ACC" is an effective medicine that is used to treat cough in childhood. The drug works carefully, so it has a minimum of contraindications. It is used to cleanse the bronchi and normalize the functioning of the respiratory system. In order to quickly achieve the intended therapeutic effect, the instructions for the ACC syrup for children must be followed, which contains information regarding the duration of treatment, dosages for each age, side effects and contraindications for use.

The composition of the children's cough medicine

Children's cough syrup is an effective medicine that is easy to give to a child. The drug has a liquid consistency and a sweet taste, so that most children take it without problems.

The composition of the syrup includes the chemical compound acetylcysteine. By its structure, it is an amino acid that is included in metabolic processes and has a mucolytic effect on the child's body.

In other words, the medicine helps to make the sputum in the bronchi more liquid and speed up the release of mucus from the airways.

To improve the taste, the manufacturer included a cherry flavor in the composition of the syrup. There are no dangerous substances, including ethanol or dyes, among the ingredients of the medicine. This means that the syrup can be safely given to children.

"ACC" for children in liquid form is available in bottles of dark dense glass. Each container is equipped with a cap that protects against accidental opening by children. The manufacturer offers two options - 100 ml and 200 ml. Each package of the product contains detailed instructions, a measuring cap and a syringe for quickly drawing up syrup.

Pharmacological properties and pharmacokinetics

Acetylcysteine ​​from the drug enters the gastrointestinal tract of the child and is absorbed into the systemic circulation from the small intestine. Further, the active substance is transported to the respiratory tract, where it begins to work. In this case, the impact is carried out immediately in three directions.

  1. In the branches of the bronchi, acetylcysteine ​​acts on disulfide bonds in sputum molecules. As a result, they are destroyed, and the mucus itself becomes more liquid and leaves the respiratory tract more easily, without lingering on their inner walls.
  2. The tool does not just thin the sputum. It protects the body from inflammation. At the same time, acetylcysteine ​​plays the role of an antioxidant that protects tissues and cells from free radicals, the concentration of which increases during illness.
  3. Acetylcysteine ​​is able to suppress the excessive activity of paracetamol, therefore, it can protect the child's body from intoxication with this drug.

The spent drug is metabolized in the liver tissues. In the cells of the gland, the active substance is transformed into cysteine ​​and cystine, as well as their derivatives. Later, they leave the body of the child with urine.

What kind of cough is the drug prescribed for?

"ACC" in the form of a syrup perfectly reduces the viscosity of sputum, so the drug is prescribed for a wet cough. It will help even if the sputum comes out very slowly or it contains impurities of pus.

The main indications for the use of children's cough syrup are:

  • laryngitis;
  • bronchitis;
  • pneumonia;
  • lung abscess;
  • COPD;
  • cystic fibrosis.

According to doctors, ACC will become one of the key elements in the treatment of these diseases, however, in some cases, taking the medication will not have the desired effect.

"ACC" is meaningless to take with rhinopharyngitis - a condition in which coughing is the result of a runny nose and not accumulation of mucus in the bronchi.

In this case, it is important to act on the cause of the symptom.

Instructions for use of ACC cough syrup for children

Syrup "ACC" is an excellent tool for cleansing the bronchi, which must be used strictly according to the scheme proposed by the doctor. When choosing the optimal dose, the age of the patient is taken into account.

  1. For babies from 2 to 5 years old, pediatricians prescribe 5 ml of syrup 2 or 3 times a day.
  2. Children under 14 years of age can take the medicine twice a day, 10 ml.
  3. Adolescents over 14 years old can drink 10 ml of ACC three times.

It should be borne in mind that 1 ml of the drug contains 20 mg of the active substance. The total daily allowance for children under 5 years of age should not exceed 300 mg of acetylcysteine. For older children, this threshold is higher (400 mg if the child is 6 to 14 years old, and 600 mg for teenagers).

Take cough syrup "ACC" for children immediately after meals. During treatment, you need to ensure plenty of fluids. This measure will enhance the thinning effect and allow you to quickly eliminate an unpleasant symptom.

The duration of the entire course of therapy will be determined by the doctor. Usually, "ACC" in liquid form is prescribed for 5 to 7 days, but a positive effect is observed already on the third day. An exception is the treatment of cystic fibrosis. In this case, a long-term medication will be required to prevent sudden exacerbations.

Important! The opened vial must be used within one course of therapy. The medicine will only be useful for 10 days.

It is worth paying attention to this when choosing the right volume. You need to store it in the refrigerator.

drug interaction

"ACC" is prescribed for the treatment of wet cough in pathologies of the lower respiratory tract. Such conditions often require the use of other medications, in particular antipyretic or anti-inflammatory drugs. The drug with acetylcysteine ​​in the composition does not reduce their effectiveness, therefore, it can be used without restrictions.

Doctors inform that ACC should not be taken simultaneously with any medications designed to cure a dry cough. Such medicines block the reflex center. As a result, the cough is suppressed, but sputum still continues to accumulate in the lungs, which can provoke its stagnation and subsequent inflammatory process.

In addition, ACC is taken with caution with antibiotics of the penicillin or tetracycline series. There is a chance that the cough medicine will reduce the antimicrobial effect and the treatment will be delayed. To avoid this, you need to take a two-hour break between taking ACC and antibiotic.

Contraindications, side effects and overdose

"ACC" should be taken strictly in the dosage suggested by the doctor. Otherwise, instead of the expected quick recovery, side effects will develop.

The most common include:

  • headache;
  • noise in ears;
  • nausea;
  • diarrhea;
  • skin rashes;
  • edema.

In cases of overdose, the listed side effects will be most pronounced, however, clinical studies confirm that drug intoxication was not observed even when used by healthy people.

"ACC", like all medicines, has its own contraindications.

The syrup should not be taken with:

  • high sensitivity to the active substance;
  • stomach ulcer in acute form;
  • bleeding in the lungs.

Analogues of ACC syrup

ACC is not the cheapest cough medicine. The average price for a bottle of 100 ml is 240 rubles, and for a volume of 200 ml - 350 rubles. In some cases, the pharmaceutical product can be replaced by similar drugs with the same active ingredient. Many of these tools are cheaper, but work in exactly the same way. The list of medicines with a similar composition includes Fluimucil or Acetylcysteine. They are produced in the form of granules, which require preliminary dilution in warm water.

Sometimes doctors prescribe other drugs, which include ambroxol. It also thins phlegm and frees the bronchi from viscous mucus. The most famous drugs from this group are Lazolvan and Ambrobene syrups. They are in the same price range as ACC.

Older children can be considered taking the drug "ACC", but not in the form of a syrup, but in the form of effervescent tablets or powder for dissolution in water. This medicine has an orange flavor, so children drink it without problems.

The final decision on the appointment of any drug is always made by the doctor. The pediatrician will examine the child and decide which remedy will most quickly relieve unpleasant symptoms. ACC syrup is a great option for kids over two years old who suffer from a productive cough.

For the treatment of coughing fits with sputum that does not come out well, ACC is used. With the help of this medicine, even pus can be thinned. Produced in various forms. It is worth studying in detail how ACC is used for coughing, the instructions for using the drug give precise instructions on how to dose the medicine.

Composition and properties

ACC, or ACC, is a drug with mucolytic and expectorant properties. Thanks to its use, liquefaction and accelerated discharge of viscous mucus occurs. This drug is used as a therapeutic agent for diseases of the respiratory system. What kind of cough is it used for? The medicine is effective for wet cough.

Medicines of the ACC series are produced by the Slovenian company Sandoz or the German company Hexal AG. Any of them can be purchased at a pharmacy without a doctor's prescription.

  • effervescent tablets 100 mg, 200 mg, 600 mg;
  • disposable bags with granules (powder);
  • syrup for children;
  • injection.

Effervescent tablets are white, round and flat. They dissolve very quickly in water. It turns out a clear drink. Children are treated with 100 mg tablets, and adults use 600 mg effervescent preparations. A carton usually contains 10 pieces.

The composition of effervescent products includes the main active ingredient - acetylcysteine ​​​​and excipients. Most acetylcysteine ​​is contained in 600 mg tablets, which is why they are called ACC Long.

Granules or powder for preparing a warm drink are in disposable bags. The weight of one package is only 3 g. The powder is dissolved in warm water and a drink with the taste of lemon, orange or honey is obtained. The standard package contains 6 or 20 sachets.

The syrup is mainly used to treat children, but adults can also use it if desired. 1 ml contains 20 mg of the active substance. The medicine is a viscous thick liquid with a cherry flavor. Does not contain ethyl alcohol and dyes. The syrup includes additional components - caramellose, cherry flavor, saccharinate, methyl parahydroxybenzoate, disodium edetate. In pharmacies, it is sold in dark glass bottles of 100 or 200 ml. The kit includes a 10 ml measuring cap and a 5 ml syringe.

ACC injection solution is used for inhalation or intravenously. The active substance is acetylcysteine. Transparent colorless liquid is in ampoules, in one package 5 pieces of 300 mg. The drug is used in intensive care units only if the use of tablets is not possible.

pharmachologic effect

Acetylcysteine ​​has antioxidant and pneumoprotective properties, acts as an antidote for acute paracetamol poisoning, as well as aldehydes and phenols. When taken orally, it is completely absorbed, and after 1-3 hours, the maximum concentration of the active component in the blood is observed. It is excreted from the body with urine and feces. The drug passes through the placenta, which can accumulate in the amniotic fluid.

Indications

The drug is effective in diseases of the respiratory system, when a viscous, hard-to-remove mucus is formed. ASS differs from other mucolytics in its high efficiency. The drug directly affects the sputum that has already formed, dilutes it.

The main purpose of using ACC is to reduce the viscosity of sputum. Apply it if the patient has a thick cough, and sputum does not come out well. With bronchitis, nocturnal cough decreases. True, after 18 hours the medicine can not be given. If ACC cough is taken right before bedtime, the mucus will thin out, which will cause coughing fits.

With rhinopharyngitis, the medicine will not save the patient from sputum. Viscosity may decrease, but mucus production in the nasopharynx will not stop. In this case, complex treatment is needed. ACC is used for infectious and non-infectious diseases of the bronchopulmonary system.

It is advisable to use when:

  • bronchitis;
  • cystic fibrosis;
  • bronchial asthma;
  • inflammation of the lungs;
  • otitis;
  • sinusitis;
  • bronchiectasis;
  • bronchiolitis.

Important! ACC is prescribed as a cough suppressant only when there is already mucus in the bronchi.

Instructions for use

Doses of the drug depend on the form of release and the amount of the main active ingredient. Adults and children are prescribed a different amount of medication. The instructions that are available in each package for the drug help determine the dosage.

How to use for adults:

  • effervescent preparations: ACC 200 three times a day, ACC 600, like ACC Long, once a day;
  • granules (powder): one sachet (200 mg) or 2 sachets (100 mg) three times a day;
  • syrup: 10 ml three times a day.

More than 600 mg of the drug should not be used per day. It should be treated with the drug for one week.

Dosage for children:

  • syrup: from 2 to 5 years, 5 ml - 2-3 times a day, and from 6 to 14 years, 5 ml three times or 10 ml twice a day;
  • effervescent preparations: from 2 to 5 years, one tablet (ACC 100) 2 or 3 times a day, and from 6 to 14 years, one tablet (200 mg) twice or one tablet (100 mg) three times a day;
  • granules (powder): from 2 to 5 years one sachet (100 mg) - 2 or 3 times a day, and from 6 to 14 years one sachet (200 mg) 2 times or one sachet (100 mg) three times a day.

At what age should children be given syrup? You can treat a baby with this remedy from 2 years old.

The duration of treatment for children is no more than 5 days. The maximum effect of taking the drug occurs on the 3rd day. The final dose is prescribed only by the pediatrician. Take ACC for children after meals. Additionally, it is recommended to drink plenty of fluids (herbal tea, juice, dried fruit compote). It is better for a child to give syrup, and if he does not like the taste of cherries, you can give powder, it resembles an orange.

How to use

Effervescent preparations are dissolved in warm water. The solution is prepared immediately before use. For 100 mg of the drug you need 100 ml of liquid. Granules (ACC powder) are dissolved in warm water. To do this, take a glass of liquid and pour a bag of medicine into it, mix everything and drink. The glass must be made of glass, you can not use metal utensils.

The syrup is drawn into a measuring syringe, not directed into the throat, but into the buccal region, otherwise the baby may choke. You can only draw medicine with a syringe, and then pour it into a spoon and thus give it to the child. Syrup is not mixed with water, but it can be washed down with tea or juice.

Important! Children under 2 years of age are not prescribed medication. The dosage for such babies is not indicated in the instructions, since there are a number of contraindications. If you give a medicine to a child under 2 years old without instructions from a pediatrician, then he may experience suffocation.

Overdose

Exceeding the daily dose of the drug does not cause intoxication. However, in case of an overdose, the patient may experience nausea, sometimes even vomiting, and gastrointestinal upset. Antidote in this case is not needed, symptomatic treatment.

Contraindications

ACC does not apply:

  • with an ulcer;
  • with hepatitis;
  • during pregnancy and during lactation;
  • children under 2 years old;
  • with liver failure;
  • if there is hypersensitivity to the active ingredient;
  • with bleeding from the lungs;
  • if you have fructose intolerance.

Important! Care should be taken to prescribe the drug to patients with bronchial asthma, it is necessary to ensure that bronchospasm does not occur. People with diabetes should take into account that the drug contains sucrose. ACC Long is prescribed only for children who are 14 years old.

Adverse reactions

ACC and adverse reactions:

  • nausea;
  • stomatitis;
  • vomit;
  • gastrointestinal problems;
  • hives;
  • noise in ears;
  • bronchospasm;
  • headache;

There may also be problems with the cardiovascular system in the form of increased blood pressure and arrhythmias.

Interaction with other drugs

ACC should not be used in conjunction with cough suppressants. If you inhibit the reflex contraction of the bronchi, this can lead to stagnation of mucus in them. It should not be used with oral antibiotics. The interaction of these drugs leads to a decrease in the effectiveness of both. An interval of 2 hours should be maintained between doses. True, there are exceptions to this rule: the antibiotics Loracarbef and Cefixime.

Analogues

ACC costs from 150 to 650 rubles, depending on the type. So, for example, the price of syrup for children is 300 rubles, Long effervescent preparations cost 500 rubles, and sachets - 150 rubles. If ACC is not suitable for some reason, other cough medicines for children can be purchased - for example, Bromhexine. It costs about 170 rubles. The medicine does an excellent job with coughing, and its list of contraindications is much smaller. There are other analogues in syrups: Lazolvan, Flavamed, Ambrobene.

Ascoril can be used to treat cough. The drug relieves spasms in the bronchi, has a strong mucolytic effect. Fluimucil can also be used as a drug that thins sputum in the bronchi.

Acetylcystine is a domestic analogue of ACC. It has the same effect, but costs about 130 rubles. The drug is produced in the form of granules, powders and in the form of effervescent tablets. In addition, ACC analogs are: Acestine, Mukobene, Mukomist. The selection of an analogue is carried out by a doctor.

ACC is suitable if you need to cope with sputum that is already in the bronchi. The medicine is used to treat both adults and children. Use it only as directed by a doctor, although it can be bought at a pharmacy without a prescription. Self-medication is not worth it, because you need to correctly determine the nature of the cough.

 mucolytic drug.

Preparation: ACC ®
Active ingredient: acetylcysteine
ATX code: R05CB01
KFG: Mucolytic drug
Reg. number: P No. 015474/01
Date of registration: 13.01.05
The owner of the reg. Award: HEXAL AG (Germany)

PHARMACEUTICAL FORM, COMPOSITION AND PACKAGING

Granules for oral solution (orange) white, without agglomerates and mechanical impurities, with an orange smell.

Excipients: ascorbic acid, saccharin, sucrose, orange flavor.

Granules for oral solution white, homogeneous, no more than 1.5 mm in size, without agglomerates and mechanical impurities, with the smell of lemon and honey.

Excipients: ascorbic acid, saccharin, sucrose, honey and lemon flavors.

3 g - sachets (6) - packs of cardboard.
3 g - sachets (10) - packs of cardboard.
3 g - sachets (20) - packs of cardboard.

ACC ® 100

Effervescent tablets white, round, flat, with the smell of blackberries.

Excipients:







ACC ® 200

Effervescent tablets white, round, flat, with a risk, with the smell of blackberries.

Excipients: ascorbic acid, citric acid anhydride, lactose anhydride, mannitol, sodium citrate, sodium bicarbonate, saccharin, blackberry flavor.

4 things. - strips (15) - cardboard boxes.
20 pcs. - aluminum tubes (1) - cardboard boxes.
20 pcs. - plastic tubes (1) - cardboard boxes.
25 pcs. - aluminum tubes (2) - cardboard boxes.
25 pcs. - plastic tubes (2) - cardboard boxes.
25 pcs. - aluminum tubes (4) - cardboard boxes.
25 pcs. - plastic tubes (4) - cardboard boxes.

ACC ® LONG

Effervescent tablets white, round, with a smooth surface, with a risk, with a smell of blackberry.

Excipients: anhydrous citric acid, sodium bicarbonate, anhydrous sodium carbonate, mannitol, anhydrous lactose, ascorbic acid, sodium cyclamate, sodium saccharinate dihydrate, sodium citrate dihydrate, blackberry flavor "B".

6 pcs. - polypropylene tubes (1) - cardboard packs.
10 pieces. - polypropylene tubes (1) - cardboard packs.
20 pcs. - polypropylene tubes (1) - cardboard packs.

The description of the drug is based on the officially approved instructions for use.

PHARMACHOLOGIC EFFECT

mucolytic drug. The presence of sulfhydryl groups in the structure of the acetylcysteine ​​molecule contributes to the breaking of disulfide bonds of sputum acid mucopolysaccharides, which leads to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

PHARMACOKINETICS

Data on the pharmacokinetics of the drug ACC are not provided.

INDICATIONS

Respiratory diseases accompanied by increased formation of viscous mucus that is difficult to separate (acute and chronic bronchitis, obstructive bronchitis, pneumonia, bronchiectasis, bronchial asthma, bronchiolitis, cystic fibrosis, laryngitis);

Acute and chronic sinusitis;

Otitis media.

DOSING MODE

Adults and teenagers over 14 years old it is recommended to prescribe the drug 200 mg 2-3 times / day (ACC 100 or ACC 200), or 200 mg 3 times / day (ACC in the form of granules for oral solution 200 mg) or 600 mg 1 time / day (ACC LONG or ACC in the form of granules for oral solution 600 mg).

Children aged 2 to 5 years the drug is recommended to take 100 mg 2-3 times / day (ACC 100 or ACC 200).

At cystic fibrosischildren over the age of 6 the drug is recommended to be taken 200 mg 3 times / day (ACC 100, ACC 200 or ACC in the form of granules for the preparation of a solution for oral administration of 200 mg). Children aged 2 to 6 years- 100 mg 4 times / day (ACC 100 or ACC 200). Patients with weighing more than 30 kg with cystic fibrosis, if necessary, you can increase the dose to 800 mg / day.

At sudden short colds the duration of admission is 5-7 days. At chronic bronchitis and cystic fibrosis the drug should be used longer to prevent infections.

The drug should be taken after meals. Additional fluid intake enhances the mucolytic effect of the drug.

Effervescent tablets (ACC 100 and ACC 200) should be dissolved in 1/2 glass of water, effervescent tablets (ACC LONG) should be dissolved in 1 glass of water. Take immediately after dissolution, in exceptional cases, you can leave the finished solution for 2 hours.

Granules for the preparation of a hot drink (1 sachet) are dissolved with stirring in 1 glass of hot water and drunk, if possible, hot. If necessary, you can leave the prepared solution for 3 hours.

Granules for oral solution (orange scent) should be dissolved in water, juice or iced tea and taken after meals.

SIDE EFFECT

From the side of the central nervous system: rarely - headaches, tinnitus.

From the digestive system: rarely - stomatitis; in some cases - diarrhea, vomiting, heartburn and nausea.

From the side of the cardiovascular system: in some cases - a drop in blood pressure, tachycardia.

From the respiratory system: in isolated cases - the development of pulmonary bleeding as a manifestation of a hypersensitivity reaction.

Allergic reactions: in isolated cases - bronchospasm (mainly in patients with a hyperreactive bronchial system in bronchial asthma), skin rash, itching and urticaria.

CONTRAINDICATIONS

Peptic ulcer of the stomach and duodenum in the acute phase;

Hemoptysis;

Pulmonary bleeding;

Pregnancy;

lactation period (breastfeeding);

Children's age up to 6 years (preparation in the form of granules for the preparation of a solution for oral administration of 200 mg);

Children's age up to 14 years (dosage forms of the drug containing 600 mg of acetylcysteine);

Hypersensitivity to acetylcysteine ​​and other components of the drug.

With caution the drug should be used in patients with varicose veins of the esophagus, with an increased risk of developing pulmonary hemorrhage and hemoptysis, with bronchial asthma, diseases of the adrenal glands, liver and / or kidney failure.

ACC LONG should not be administered to children under 14 years of age. In this category of patients, it is recommended to use dosage forms of the drug for oral administration with a lower content of acetylcysteine.

PREGNANCY AND LACTATION

Due to insufficient data, the use of the drug during pregnancy and lactation is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus or child.

SPECIAL INSTRUCTIONS

In bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be administered with caution under the systematic control of bronchial patency.

With the development of side effects, you should stop taking the drug.

When dissolving the drug, it is necessary to use glassware, avoid contact with metals, rubber, oxygen, easily oxidized substances.

1 effervescent tablet ACC 100 and ACC 200 corresponds to 0.006 XE.

1 effervescent tablet ACC LONG corresponds to 0.01 XE.

ACC (in the form of granules for oral solution 200 mg) corresponds to 0.21 XE, ACC (in the form of granules for oral solution 600 mg) - 0.17 XE.

ACC (in granules for oral solution 100 mg and 200 mg with the smell of orange) 100 mg corresponds to 0.24 XE, 200 mg - 0.23 XE.

Pediatric use

OVERDOSE

Symptoms: possible diarrhea, vomiting, stomach pain, heartburn, nausea.

Treatment: conducting symptomatic therapy.

DRUG INTERACTIONS

With the simultaneous use of acetylcysteine ​​​​and antitussives, due to the suppression of the cough reflex, dangerous mucus stagnation may occur (use the combination with caution).

With the simultaneous administration of acetylcysteine ​​and nitroglycerin, the vasodilating effect of nitroglycerin may be enhanced.

Synergism of acetylcysteine ​​with bronchodilators is noted.

Pharmaceutical interaction

Acetylcysteine ​​is pharmaceutically incompatible with antibiotics (penicillins, cephalosporins, erythromycin, tetracycline and amphotericin B) and proteolytic enzymes.

Acetylcysteine ​​reduces the absorption of cephalosporins, penicillins and tetracyclines, so they should be taken orally no earlier than 2 hours after taking acetylcysteine.

Upon contact of acetylcysteine ​​with metals, rubber, sulfides are formed with a characteristic odor.

TERMS AND CONDITIONS OF DISCOUNT FROM PHARMACIES

The drug is approved for use as a means of OTC.

TERMS AND CONDITIONS OF STORAGE

The drug should be stored in a dry place, out of the reach of children, at a temperature not exceeding 25°C. Shelf life - 3 years, the shelf life of granules for oral solution (with the smell of orange) - 4 years.

ACC LONG should be stored in a dry, dark place, out of the reach of children, at a temperature not exceeding 30°C. Shelf life - 3 years.

After taking the pill, the tube should be tightly closed.

 ACC (ACC)

Compound

Effervescent tablets: acetylcysteine ​​and auxiliary components (ascorbic acid, sucrose, saccharin, flavoring).

Powder: acetylcysteine ​​and auxiliary components (sucrose).

ACC Long effervescent tablets: acetylcysteine ​​and auxiliary components (ascorbic acid, sodium citrate, saccharin, sodium cyclamate, lactose, citric acid, sodium carbonate, mannitol, sodium bicarbonate, flavoring).

ACC for children: acetylcysteine.

pharmachologic effect

The active substance is acetylcysteine, a cysteine ​​derivative (amino acid). It has a mucolytic, expectorant effect due to the rupture of bisulfide bonds of sputum mucopolysaccharides. This depolymerizes mucoproteins and reduces the viscosity of bronchial secretions. As a result, mucociliary clearance increases and sputum discharge improves. Acetylcysteine ​​has an antioxidant and pneumoprotective effect, which is associated with the binding properties of sulfhydryl groups. It is an antidote for acute poisoning with aldehydes, paracetamol and phenols (the detoxifying effect is possible due to increased production of glutathione).

Acetylcysteine ​​is almost immediately completely absorbed from the gastrointestinal tract when administered internally. The active metabolite is cysteine, which is formed in the liver. Further, the metabolism of acetylcysteine ​​passes through the formation of diacetylcysteine, cystine. The end product of metabolism is mixed disulfides.

Bioavailability is 10%. Cmax is determined by internal use after 1-3 hours. Plasma proteins bind 50% of acetylcysteine. The maximum concentration of the pharmacologically active metabolite in the blood is 2 µmol/L.

Inactive metabolites are excreted in the urine (inorganic sulfates, diacetylcysteine), but a small amount of acetylcysteine ​​is excreted unchanged in the feces.

The half-life of acetylcysteine ​​depends on biotransformation in the liver. With liver failure, it is 8 hours, while normally it is 1 hour. It passes through the hematoplacental barrier and can accumulate in the amniotic fluid.

Indications for use

Acetylcysteine ​​is prescribed in all cases of diseases with accumulation of thick viscous sputum in the bronchial tree and upper respiratory tract, namely:
Acute and chronic bronchitis, including obstructive;
bronchiolitis;
tracheitis;
Bronchial asthma ;
bronchiectasis;
cystic fibrosis;
Laryngitis;
sinusitis;
Median exudative otitis.

Mode of application

The daily dose for the treatment of cystic fibrosis in patients weighing more than 30 kg is used up to 800 mg. Children from the 10th day of life and up to 2 years old use 50 mg 2-3 r / s. At the age of 2-5 years - 400 mg per day, divided into 4 doses. From 6 years old - 600 mg / s (divided into 3 doses). Treatment is continued for a long time, courses for several months (3-6).
In all other cases, the daily dose for children from 14 years of age and adults is 400-600 mg. From 6 to 14 years - 300-400 mg (divided into 2 doses), 2-5 years - 200-300 mg (divided into 2 doses). Children from the 10th day of life and up to 2 years old use 50 mg 2-3 r / s. In acute diseases without complications, the drug is prescribed for 5-7 days. In case of complications or chronic course, course treatment is possible (up to 6 months).

ACC is taken after a meal. The tablet or the contents of the sachet must be dissolved in half a glass of liquid (cold tea, water, juice).

Side effects

From the gastrointestinal tract - stomatitis, nausea, vomiting, diarrhea, heartburn.
From the side of the central nervous system - headache, tinnitus.
From the side of the CCC - arterial hypotension, increased heart rate.

Allergic reactions - bronchospasm (especially with bronchial hyperreactivity), rash and itching of the skin. Often the cause of hypersensitivity to the drug is the presence of propyl and methyl parahydroxybenzoate in the composition.

Contraindications

Hypersensitivity to acetylcysteine ​​and excipients
peptic ulcer
hereditary fructose intolerance
Pulmonary bleeding or hemoptysis
In pediatric practice - with hepatitis and renal failure (the threat of accumulation of nitrogen-containing products).

Pregnancy

There is no embryotoxic effect in acetylcysteine, however, during pregnancy, as well as during breastfeeding, it is prescribed only if there are indications under the supervision of a physician.

drug interaction

Tetracycline and its derivatives (except doxycycline) should not be used together with ACC in pediatrics.
During experimental in vitro studies, there were no cases of inactivation of other types of antibacterial drugs. However, it is recommended to observe the interval between taking ACC and antibiotic at least 2 hours. In vitro, the incompatibility of acetylcysteine ​​with semi-synthetic penicillins, aminoglycoside and cephalosporin antibiotics has been proven. Such studies have not been conducted with erythromycin, amoxicillin and cefuroxime.

Simultaneous use of antitussive drugs can lead to stagnation of the secretion of the respiratory tract.

The use of nitroglycerin may enhance the vasodilating effect of the latter.

Overdose

In pediatric practice, cases of hypersecretion in infants are described. Side effects that threaten life and health are not described. In case of overdose (dyspeptic disorders), symptomatic therapy is prescribed.

Release form

ACC 100, 200 - effervescent tablets, 20 pcs.
ACC hot drink - powder for preparing a hot drink for internal use - 200 mg (20 sachets) and 600 mg (6 sachets).
ACC-long - effervescent tablets (600 mg), 10 pcs. in a tube.
ACC powder for solution for oral administration - 100, 200 mg, 2 pcs. packaged.

ACC for children - powder for the preparation of a solution for oral administration 30 g in a 75 ml vial (20 mg / ml) and 60 g in a 150 ml vial (20 mg / ml).

Storage conditions

In places inaccessible to children. Temperature not more than 30°С. The finished solution should be stored for no more than 12 days in the refrigerator (at a temperature of 2-8°C).

Nosological classification (ICD-10)

Acute sinusitis (J01)

Acute obstructive laryngitis [croup] and epiglottitis (J05)

Bacterial pneumonia, not elsewhere classified (J15)

Acute bronchitis (J20)

Chronic sinusitis (J32)

Chronic laryngitis and laryngotracheitis (J37)

Chronic bronchitis, unspecified (J42)


For the best mucolytic effect in the treatment with acetylcysteine, you should drink plenty of fluids.

10 ml of the prepared oral solution contains 0.31 carbohydrate units, which should be taken into account for patients with diabetes.

Sorbitol has a slight laxative effect on the stool.

For newborns and children under 1 year of age, acetylcysteine ​​​​is used exclusively for health reasons under strict medical supervision. The recommended dosage (10 mg/kg body weight) must not be changed.
ACC 200 is not used at the age of up to 2 years.
ACC Long is not recommended for children under 14 years of age.

The speed of reaction when driving and working with machinery does not change when taking acetylcysteine.

The authors

Attention!
Description of the drug ACC" on this page is a simplified and supplemented version of the official instructions for use. Before purchasing or using the drug, you should consult a doctor and read the annotation approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, as well as determine the dose and methods of its use.