Furosemide side effects and contraindications. Furosemide tablets: instructions for use

Photo of the preparation

Latin name: Furosemide

ATX Code: C03CA01

Active substance: Furosemide (Furosemide)

Producer: Borisov Plant of Medical Preparations (Republic of Belarus), Novosibkhimfarm, Dalchimpharm, Biochemist, Binnopharm CJSC, Ozon Pharm LLC (Russia), Mangalam Drugs & Organics Ltd, Ipca Laboratories (India)

The description applies to: 01.11.17

Diuretic furosemide tablets contain 40 mg of active substance, as well as potato starch, milk sugar, povidone, MCC, gelatin, talc, magnesium stearate, colloidal silicon dioxide.

As part of solution for intramuscular and intravenous administration the active substance is contained in a concentration of 10 mg / ml. Auxiliary components: sodium chloride, sodium hydroxide, water for injection.

Release form

The medicine is available in the form:

• tablets 40 mg No. 50 (2 packs of 25 tablets or 5 packs of 10 tablets in a pack);
• injection solution (ampoules 2 ml, package No. 10).

pharmachologic effect

Diuretic, sodium and chloruretic.

Pharmacodynamics and pharmacokinetics

Furosemide - what is it?

Furosemide is a loop diuretic diuretic , which acts mainly on the thick segment of the ascending limb of the loop of Henle. Differs in speed. The diuretic effect is pronounced, but short-lived.

How long does Furosemide take?

After oral administration, the drug begins to act after 20-30 minutes, after infusion into a vein - after 10-15 minutes.

Depending on the characteristics of the body, the effect when using the oral form of Furosemide can persist both for 3-4 and for 6 hours, while it is most powerful after an hour or two after taking the pill.

After the introduction of the solution into the vein, the effect reaches a maximum after half an hour and lasts for 2-8 hours (the more pronounced kidney dysfunction the longer the drug lasts).

Pharmacodynamics

The mechanism of action of the drug is associated with a violation of reabsorption in the tubules of the nephrons of the kidneys of chloride and sodium ions. In addition, Furosemide increases the excretion of magnesium, calcium, phosphates and bicarbonates.

The use of the drug in patients with fromheart failure leads to a decrease in preload on the heart muscle after 20 minutes.

The hemodynamic effect reaches its maximum severity by the 2nd hour of Furosemide action, which is due to a decrease in the tone of the veins, a decrease in BCC (the volume of circulating blood), as well as the volume of fluid filling the intercellular spaces in organs and tissues.

Reduces blood pressure. The effect develops as a consequence:

• reducing the response of the muscles of the vascular walls to vasoconstrictor (provoking vasoconstriction and a decrease in blood flow in them) exposure;
• decrease in BCC;
• increase in excretion sodium chloride .

During the period of action of Furosemide, the excretion of Na + ions increases significantly, however, after the termination of the action of the drug, the rate of their excretion falls below the initial level (“withdrawal” or “rebound” syndrome). Due to this, when administered once a day, it does not have a significant effect on blood pressure and daily excretion of Na.

The reason for this effect is a sharp activation of antinatriuretic links of neurohumoral regulation (in particular, renin-angiotensin) in response to massive diuresis.

The drug stimulates the sympathetic and arginine vasopressive systems, reduces the plasma concentration of atriopeptin, and causes vasoconstriction.

Pharmacokinetics

Absorption from the digestive tract is high, bioavailability (the proportion of absorbed drug) when taken orally is from 60 to 70%. The plasma protein binding rate is 98%.

TSmax when taken per os - 1 hour, when infused into a vein - 0.5 hours.

Furosemide is able to cross the placenta and be excreted in breast milk.

The substance undergoes biotransformation in the liver. Metabolites are secreted into the lumen of the tubules of the kidneys.

T1 / 2 for the oral form of the drug - from one hour to one and a half hours, for parenteral - from half an hour to an hour.

From 60 to 70% of the dose taken orally is excreted by the kidneys, the rest - with faeces. When injected into a vein, about 88% of furosemide and its metabolic products are excreted by the kidneys, with feces - about 12%.

Furosemide indications for use

Furosemide - what are these pills for?

Tablets are prescribed for:

• edema, the causes of which are pathologies of the kidneys (including nephrotic syndrome ), CHF II-III stage or ;
• appearing in the form pulmonary edema acute heart failure ;
• hypertensive crisis (as a monotherapy or in combination with other drugs);
• severe forms arterial hypertension ;
• cerebral edema ;
• hypercalcemia ;
• eclampsia .

The drug is also used for forced diuresis in case of poisoning with chemicals that are excreted from the body by the kidneys in unchanged form.

With increased blood pressure that develops against the background of chronic renal failure, Furosemide is prescribed if the patient is contraindicated thiazide diuretics , and also if Clcr does not exceed 30 ml per minute).

Indications for use of Furosemide in ampoules

In the annotation for Furosemide in ampoules, the same indications for use are given as for the tablet form of the drug.

With parenteral administration, the drug acts faster than when taken orally. Therefore, doctors answer the question “What is the solution for?”, Answer that the introduction of Furosemide IV allows you to quickly reduce pressure (arterial, in the pulmonary artery, in the left ventricle) and preload on the heart, which is extremely important in emergency conditions (for example , at hypertensive crisis ).

When the drug is prescribed for nephrotic syndrome treatment of the underlying disease should come first.

Furosemide contraindications

The drug is not prescribed for:

• intolerance to its components;
• OPN, which is accompanied anuria (if the value of GFR does not exceed 3-5 ml / min.);
• urethral stenosis ;
• severe liver failure ;
• hepatic coma ;
• hyperglycemic coma ;
• precomatose states;
• obstruction of the urinary tract by a calculus;
• decompensated stenosis of the mitral valve or the mouth of the aorta;
• conditions in which blood pressure in the right atrium exceeds 10 mm Hg. Art.;
• hyperuricemia ;
• (in the acute stage);
• arterial hypertension ;
• hypertrophic subaortic stenosis ;
• violations of water-salt metabolism (hypocalcemia, hypochloremia, hypomagnesemia, etc.);
• digitalis intoxication (intoxication caused by the intake of cardiac glycosides).

Relative contraindications to the use of Furosemide:

• benign prostatic hyperplasia (BPH);
• hypoproteinemia (when taking the drug, the risk of developing ototoxicity increases);
• obliterating cerebral atherosclerosis ;
• hepatorenal syndrome ;
• hypotension in patients at risk of ischemia (coronary, cerebral or otherwise), which is associated with circulatory failure;
• hypoproteinemia on the background nephrotic syndrome (it is possible to increase the undesirable side effects of Furosemide (especially ototoxicity) and reduce its effectiveness).

Patients at risk should be under constant medical supervision. Violation of the KShchR, hypovolemia or dehydration are grounds for reviewing the treatment regimen and, if necessary, temporarily discontinuing the drug.

Diuretics contribute to the excretion of sodium from the body, therefore, in order to avoid the development hyponatremia before starting therapy and subsequently throughout the entire course of Furosemide, it is necessary to control the sodium level in the patient's blood (especially in patients with cachexia , cirrhosis as well as in the elderly).

Application loop diuretics may cause sudden hypokalemia . The risk group includes:

• aged people;
• patients who are not receiving adequate nutrition and / or taking several drugs at the same time;
• patients diagnosed with cirrhosis with ascites ;
• patients with heart failure .

hypokalemia raises cardiotoxicity of digitalis preparations (Digitalis) and risk cardiac arrhythmias . At long QT interval syndrome (congenital or drug-induced) hypokalemia contributes to the emergence bradycardia or potentially life-threatening torsades de pointes .

In diabetics throughout the course of treatment, it is necessary to systematically monitor the level of sugar.

Additional Information

The drug is not doping, but it is often used to remove prohibited substances from the body, as well as a means of losing weight in sports where the weight of the athlete is important. In this regard, Furosemide is equated to doping drugs and cannot be used in athletes.

Side effects of furosemide

Against the background of the use of the drug, the following side effects may occur:

• cardiovascular disorders , including orthostatic hypotension , arterial hypotension , arrhythmias , tachycardia , collapse ;
• dysfunctions of the nervous system manifested by dizziness, muscle weakness, headache, tetany , apathy , adynamia , paresthesia , drowsiness, lethargy, weakness, confusion;
• sensory dysfunction (in particular, hearing and vision impairments);
• disorders of the digestive system, including dry mouth, anorexia , cholestatic jaundice diarrhea/constipation, nausea, vomiting, exacerbation ;
• disorders of the urogenital tract, including oliguria , interstitial nephritis , acute urinary retention (with BPH), hematuria , impotence ;
• hypersensitivity reactions, including exfoliative dermatitis , , purpura ,necrotizing angiitis , vasculitis , erythema multiforme , chills, pruritus, photosensitivity, fever , anaphylactic shock ;
• disorders of the hematopoietic organ system, including aplastic anemia , thrombocytopenia , leukopenia , ;
• disorders of water-salt metabolism, including dehydration and, as a result, an increased risk thrombosis/thromboembolism , hypovolemia , hypomagnesemia , hypochloremia , hypokalemia ,hypocalcemia , hyponatremia , metabolic acidosis ;
• changes in laboratory parameters, including hypercholesterolemia , hyperglycemia , glycosuria , hyperuricemia .

When furosemide is administered intravenously, it may develop and in newborn babies kidney calcification .

Instructions for use Furosemide

How to take Furosemide for swelling?

Diuretic tablets take inside. The doctor selects the dose individually, depending on the indications and the characteristics of the course of the disease.

An adult with edema that has developed against the background of pathologies of the liver, kidneys or heart is prescribed to take ½-1 tablet / day, if the condition is assessed as moderate. In severe cases, the doctor may recommend taking 2-3 tablets. 1.r./day or 3-4 tab. in 2 doses.

How to lower blood pressure with Furosemide?

To reduce elevated blood pressure in patients with chronic renal failure, the drug is used in combination with antagonists of the renin-angiotensive system. The recommended dose varies from 20 to 120 mg/day. (½-3 tablets / day). The medicine is taken in one or two doses.

Furosemide for weight loss

Some women use the properties of the drug for weight loss. Taking Furosemide tablets (Furosemide Sopharma) really allows you to get rid of several kilograms, but this weight loss can hardly be called weight loss, since the drug does not remove excess fat in problem areas, but only removes water from the body.

Application instruction of Furosemide in ampoules

The preferred method of administering the solution is by slow intravenous injection (performed within 1-2 minutes).

The drug is administered into the muscle in exceptional cases, when the oral or intravenous route of administration is not possible. Contraindications for intramuscular administration of Furosemide are acute conditions (for example, pulmonary edema ).

Taking into account the clinical condition of the patient, it is recommended to transfer from the parenteral to the oral route of administration of Furosemide as soon as possible.

The question of the duration of treatment is decided taking into account the nature of the disease and the severity of the symptoms. The manufacturer recommends using the lowest possible dose at which the therapeutic effect will be maintained.

At edematous syndrome in adults and adolescents over 15 years of age, treatment begins with the introduction into a vein (in exceptional cases - into the muscle) of 20-40 mg of Furosemide.

In the absence of a diuretic effect, the drug is continued to be administered every 2 hours at a dose increased by 50%. Treatment according to this scheme is continued until adequate diuresis is achieved.

A dose greater than 80 mg should be administered by drip into a vein. The rate of administration should not exceed 4 mg/min. The maximum allowable dose is 600 mg / day.

In case of poisoning, to maintain forced diuresis, the patient should be administered from 20 to 40 mg of the drug, after dissolving the required dose in the infusion solution of electrolytes. Further treatment is carried out depending on the volume of diuresis. It is obligatory to replace the salts and fluids lost by the body.

Starting dose at hypertensive crisis - 20-40 mg. In the future, it is adjusted taking into account the clinical response.

Furosemide injections and tablets: instructions for use in children

In pediatrics, the dose is selected depending on the weight of the patient. Furosemide in tablets is given to a child at the rate of 1-2 mg / kg / day. The dose can be taken in one dose or divided into two doses.

The questions of how often you can drink the drug in a particular case, as well as how long the course of treatment will be, can only be answered by the attending physician. Only recommendations on what to take Furosemide with are unequivocal: as an addition to diuretics, you should definitely drink potassium preparations.

Intravenously for children under 15 years of age, the drug is administered at a dose of 0.5-1.5 mg / kg / day.

Furosemide tablets: what are they used for in veterinary medicine?

Why is Furasemide Sopharma used in veterinary medicine? In veterinary practice, Furosemide and similar drugs are used as part of complex therapy for the treatment of heart pathologies in dogs.

The use of diuretics allows you to remove the fluid that accumulates around the lungs, abdominal or chest cavity, and thereby reduce the load on the heart.

For dogs, the dosage of Furosemide depends on the weight of the animal. As a rule, the drug is given 2 times a day at the rate of 2 mg / kg. As an adjunct to treatment, it is recommended that the dog be given bananas daily (one per day) to compensate for potassium losses.

Overdose

Furosemide overdose symptoms:

• a sharp drop in blood pressure;
• hypovolemia ;
• dehydration;
• collapse ;
• hemoconcentration ;
• arrhythmias (including atrioventricular block and fibrillation (flicker) of the ventricles);
• confusion;
• drowsiness;
• arrester with anuria ;
• apathy;
• flaccid paralysis.

To normalize the patient's condition, measures are prescribed aimed at correcting the CSR and water-salt metabolism, replenishing the BCC deficiency. Further treatment is symptomatic.

Furosemide has no specific antidote.

Interaction

Furosemide increases concentration and toxicity (in particular, oto- and nephrotoxicity) Ethacrynic acid ,Aminoglycosides , Cephalosporins , , Chloramphenicol , Amphotericin B .

Enhances therapeutic efficacy And Dazoxide , reduces efficiency Allopurine And hypoglycemic drugs .

Reduces the rate of renal excretion of Li + drugs from the blood, thereby increasing the likelihood of intoxication with them.

Enhances induced by non-depolarizing muscle relaxants (peripherally acting relaxants) neuromuscular blockade and action antihypertensive drugs , weakens the effect non-depolarizing relaxants .

In combination with pressor amines, there is a mutual decrease in the effectiveness of drugs, with Amphotericin B and GCS - increases the risk of developing hypokalemia .

Use in combination with cardiac glycosides (SG) can provoke the development of the toxic effects inherent in the latter due to a decrease in the level of potassium in the blood (for low- and high-polarity SGs) and an extension of the half-life (for low-polarity SGs).

Drugs that block tubular secretion increase the serum concentration of furosemide.

Analogues of the parenteral form of the drug: Furosemide-Darnitsa , Furosemide-Vial , Lasix .

Which is better - Lasix or Furosemide?

Lasix is one of the trade names for furosemide. The drug is produced by the Indian company Sanofi India Ltd. and, like its analogue, has two dosage forms: a one-percent solution for injection and tablets of 40 mg.

Thus, when choosing one or another means, one should be guided by subjective feelings. The advantage of Furosemide is its lower price.

furosemide and alcohol

Alcohol is contraindicated in patients taking Furosemide.

Furosemide for weight loss

There is a lot of advice on the Internet about how to use diuretics for weight loss. One of the most affordable drugs in this group is Furosemide.

What does the medicine help? According to the instructions, Furosemide is used for ascites , edematous syndrome , hypertension . Thus, the manufacturer does not report anything regarding the possibility of using diet pills.

However, many women note that with the help of this tool they were able to lose a few kilograms quite quickly (in some cases, up to 3 kg per night). However, it is impossible to regard such weight loss as weight loss: the action of the drug is aimed at removing excess fluid, and by no means at breaking down fat.

Why is furosemide dangerous?

Application diuretics for weight loss can cause serious health problems, because removing water, these drugs also upset the balance of electrolytes in the body. one of the most common side effects is hypokalemia .

Potassium deficiency, in turn, leads to muscle cramps, weakness, visual disturbances, sweating, loss of appetite, nausea, and dizziness.

A very dangerous side effect is arrhythmia . SOLVD studies have shown that treatment loop diuretics accompanied by an increase in mortality among patients. At the same time, both overall and cardiovascular mortality, as well as the number of sudden deaths, are increasing.

Another danger that can be caused by uncontrolled use diuretics for weight loss, is a violation of the kidneys. Moreover, it may take more than one month to restore the function of the kidneys and lymphatic system.

How to take Furosemide for weight loss?

To remove a few extra pounds, women usually take 2-3 (no more!) Furosemide tablets during the day with an interval of three hours between doses, and then 2 more tablets at night.

You can repeat the one-day course no earlier than in 2-3 days.

Furosemide and Asparkam for weight loss

Since one of the side effects of Furosemide is hypokalemia , it is very important to follow a certain diet while using this drug (meaning the use of foods high in potassium) or to additionally take medicines that can minimize the inherent diuretics side effects.

As a rule, Furosemide is recommended to be taken in combination with () . What's happened Asparkam ? This is a drug that is used as an additional source of potassium and magnesium. The drug has a harmless composition, which eliminates the possibility of its undesirable interaction with Furosemide.

Recommendations on how to drink with Asparkam diuretic drugs only a doctor can give. Tablets Asparkama , according to the manufacturer's instructions, take 3-6 pieces per day, dividing the indicated dose into three doses.

How often can Furosemide be taken for weight loss?

Optimal - never. In extreme cases, it is allowed to use the drug as a means of emergency care when you need to urgently remove swelling.

Release form: Solid dosage forms. Tablets.

General characteristics. Composition:

Pharmacological properties:

Indications for use:

Important! Get to know the treatment

Dosage and administration:

Application Features:

Side effects:

Interaction with other drugs:

Overdose:

Storage conditions:

Store in a dry, dark place and out of the reach of children at a temperature not exceeding 25°C.

Shelf life - 2 years.

Leave conditions:

On prescription

Package:

10 tablets in a blister pack; 5 contour packs in a pack.

Country of origin

Product group

Diuretic

Release form

• 10 - blister packs (5) - cardboard packs 50 - polymer bottles (1) - cardboard packs. 10 ampoules of 2.0 in a carton 2 ml - ampoules (10) - packs of cardboard 2 ml - dark glass ampoules (10) - packs of cardboard. 2 ml - dark glass ampoules (10) - packs of cardboard. 2 ml - dark glass ampoules (1) - packs of cardboard. 2 ml - dark glass ampoules (5) - contour plastic packaging (1); (2) - packs of cardboard. 20 pcs. - packings are cell planimetric. 50 tabs per pack solution for intravenous and intramuscular administration, 20 mg ampoules, 2 ml per ampoule - 10 pcs per pack. 40 mg tablets, 50 tablets per pack

Description of the dosage form

• Tablets of white color with a creamy tint, flat-cylindrical, with a bevel. round biconvex tablets of white or almost white color. . Clear, colorless or slightly colored liquid Solution for intravenous and intramuscular injection Solution for injection Solution for injection 1% transparent Tablets

pharmachologic effect

Pharmacokinetics

Special conditions

Composition

• 1 amp. furosemide 20 mg 1 amp. furosemide 20 mg 1 tab. furosemide 40 mg 1 tablet contains: active ingredient: furosemide - 40 mg; excipients: milk sugar, potato starch, magnesium stearate. 1 ml 1 amp. furosemide 10 mg 20 mg 1 tab. furosemide 40 mg Furosemide 40 mg; Auxiliary in-va: milk sugar, potato starch, magnesium stearate

Furosemide indications for use

• Edema syndrome of various origins, incl. with chronic heart failure stage II-III, cirrhosis of the liver (portal hypertension syndrome), nephrotic syndrome. Pulmonary edema, cardiac asthma, cerebral edema, eclampsia, forced diuresis, severe arterial hypertension, some forms of hypertensive crisis, hypercalcemia.

Furosemide contraindications

• Acute glomerulonephritis, urethral stenosis, urinary tract stone obstruction, acute renal failure with anuria, hypokalemia, alkalosis, precoma, severe liver failure, hepatic coma and precoma, diabetic coma, precoma, hyperglycemic coma, hyperuricemia, gout, decompensated mitral or aortic stenosis, hypertrophic obstructive cardiomyopathy, increased central venous pressure (more than 10 mm Hg), arterial hypotension, acute myocardial infarction, pancreatitis, impaired water and electrolyte metabolism (hypovolemia, hyponatremia, hypokalemia, hypochloremia, hypocalcemia, hypomagnesemia), digitalis intoxication, hypersensitivity to furosemide. During pregnancy, the use of furosemide is possible only for a short time and only if the expected benefit of therapy for the mother outweighs the potential risk to the fetus. See instructions for details.

Furosemide dosage

• 0.04 g 1% 10 mg/ml 20 mg/2 ml 40 mg 40 mg

Furosemide side effects

• From the side of the cardiovascular system: a pronounced decrease in blood pressure, collapse, tachycardia, arrhythmias, a tendency to thrombosis, a decrease in circulating blood volume. From the side of the central nervous system: dizziness, headache, muscle weakness, spasms of the calf muscles (tetany), paresthesia, apathy, adynamia, weakness, lethargy, drowsiness, confusion. From the senses: impaired vision and hearing, tinnitus. From the digestive system: anorexia, dryness of the oral mucosa, thirst, nausea, vomiting, diarrhea, constipation, cholestatic jaundice, pancreatitis (exacerbation), hepatic encephalopathy. From the genitourinary system: oliguria, acute urinary retention (in patients with benign prostatic hyperplasia), interstitial nephritis, hematuria, reduced potency. On the part of the endocrine system: decreased glucose tolerance, manifestation of latent diabetes mellitus. Allergic reactions: purpura, urticaria, exfoliative dermatitis, erythema multiforme exudative, vasculitis, necrotizing angiitis, pruritus, chills, fever, photosensitivity, anaphylactic shock, Stevens-Johnson syndrome, bullous pemphigitis, toxic epidermal necrolysis. On the part of the hematopoietic organs: leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia, eosinophilia. From the side of water and electrolyte metabolism: hypovolemia, dehydration (risk of thrombosis and thromboembolism), hypokalemia, hyponatremia, hypochloremia, hypocalcemia, hypomagnesemia, metabolic alkalosis. Laboratory indicators: hyperglycemia, hypertriglyceridemia, hypercholesterolemia, hyperuricemia, glucosuria, hypercalciuria, increased activity of hepatic transaminases, eosinophilia.

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The description is up to date 18.09.2015

• Latin name: Furosemide
• ATX code: C03CA01
• Active substance: Furosemide (Furosemide)
• Manufacturer: Borisov Plant of Medicinal Products (Republic of Belarus), Novosibkhimfarm, Dalchimpharm, Biochemist, Binnopharm CJSC, Ozon Pharm LLC (Russia), Mangalam Drugs & Organics Ltd, Ipca Laboratories (India)

Diuretic furosemide tablets contain 40 mg of active substance, as well as potato starch, milk sugar, povidone, MCC, gelatin, talc, magnesium stearate, colloidal silicon dioxide.

As part of solution for intramuscular and intravenous administration the active substance is contained in a concentration of 10 mg / ml. Auxiliary components: sodium chloride, sodium hydroxide, water for injection.

Release form

The medicine is available in the form:

• tablets 40 mg No. 50 (2 packs of 25 tablets or 5 packs of 10 tablets in a pack);
• injection solution (ampoules 2 ml, package No. 10).

pharmachologic effect

Diuretic, sodium and chloruretic.

Pharmacodynamics and pharmacokinetics

Furosemide - what is it?

Furosemide is a "loop" diuretic diuretic , which acts mainly on the thick segment of the ascending limb of the loop of Henle. Differs in speed. The diuretic effect is pronounced, but short-lived.

How long does Furosemide take?

After oral administration, the drug begins to act after 20-30 minutes, after infusion into a vein - after 10-15 minutes.

Depending on the characteristics of the body, the effect when using the oral form of Furosemide can persist both for 3-4 and for 6 hours, while it is most powerful after an hour or two after taking the pill.

After the introduction of the solution into the vein, the effect reaches a maximum after half an hour and lasts for 2-8 hours (the more pronounced kidney dysfunction the longer the drug lasts).

Pharmacodynamics

The mechanism of action of the drug is associated with a violation of reabsorption in the tubules of the nephrons of the kidneys of chloride and sodium ions. In addition, Furosemide increases the excretion of magnesium, calcium, phosphates and bicarbonates.

The use of the drug in patients with fromheart failure leads to a decrease in preload on the heart muscle after 20 minutes.

The hemodynamic effect reaches its maximum severity by the 2nd hour of Furosemide action, which is due to a decrease in the tone of the veins, a decrease in BCC (the volume of circulating blood), as well as the volume of fluid filling the intercellular spaces in organs and tissues.

Reduces blood pressure. The effect develops as a consequence:

• reducing the response of the muscles of the vascular walls to vasoconstrictor (provoking vasoconstriction and a decrease in blood flow in them) exposure;
• decrease in BCC;
• increase in excretion sodium chloride .

During the period of action of Furosemide, the excretion of Na + ions increases significantly, however, after the termination of the action of the drug, the rate of their excretion falls below the initial level (“withdrawal” or “rebound” syndrome). Due to this, when administered once a day, it does not have a significant effect on blood pressure and daily excretion of Na.

The reason for this effect is a sharp activation of antinatriuretic links of neurohumoral regulation (in particular, renin-angiotensin) in response to massive diuresis.

The drug stimulates the sympathetic and arginine vasopressive systems, reduces the plasma concentration of atriopeptin, and causes vasoconstriction.

Pharmacokinetics

Absorption from the digestive tract is high, bioavailability (the proportion of absorbed drug) when taken orally is from 60 to 70%. The plasma protein binding rate is 98%.

TSmax when taken per os - 1 hour, when infused into a vein - 0.5 hours.

Furosemide is able to cross the placenta and be excreted in breast milk.

The substance undergoes biotransformation in the liver. Metabolites are secreted into the lumen of the tubules of the kidneys.

T1 / 2 for the oral form of the drug - from one hour to one and a half hours, for parenteral - from half an hour to an hour.

From 60 to 70% of the dose taken orally is excreted by the kidneys, the rest - with faeces. When injected into a vein, about 88% of furosemide and its metabolic products are excreted by the kidneys, with feces - about 12%.

Furosemide indications for use

Furosemide - what are these pills for?

Tablets are prescribed for:

• edema, the causes of which are pathologies of the kidneys (including nephrotic syndrome ), CHF II-III stage or cirrhosis of the liver ;
• appearing in the form pulmonary edema acute heart failure ;
• hypertensive crisis (as a monotherapy or in combination with other drugs);
• severe forms arterial hypertension ;
• cerebral edema ;
• hypercalcemia ;
• eclampsia .

The drug is also used for forced diuresis in case of poisoning with chemicals that are excreted from the body by the kidneys in unchanged form.

With increased blood pressure that develops against the background of chronic renal failure, Furosemide is prescribed if the patient is contraindicated thiazide diuretics , and also if Clcr does not exceed 30 ml per minute).

Indications for use of Furosemide in ampoules

In the annotation for Furosemide in ampoules, the same indications for use are given as for the tablet form of the drug.

With parenteral administration, the drug acts faster than when taken orally. Therefore, doctors answer the question “What is the solution for?”, Answer that the introduction of Furosemide IV allows you to quickly reduce pressure (arterial, in the pulmonary artery, in the left ventricle) and preload on the heart, which is extremely important in emergency conditions (for example , at hypertensive crisis ).

When the drug is prescribed for nephrotic syndrome treatment of the underlying disease should come first.

Furosemide contraindications

The drug is not prescribed for:

• intolerance to its components;
• OPN, which is accompanied anuria (if the value of GFR does not exceed 3-5 ml / min.);
• urethral stenosis ;
• severe liver failure ;
• hepatic coma ;
• hyperglycemic coma ;
• precomatose states;
• obstruction of the urinary tract by a calculus;
• decompensated stenosis of the mitral valve or the mouth of the aorta;
• conditions in which blood pressure in the right atrium exceeds 10 mm Hg. Art.;
• gout ;
• hyperuricemia ;
• myocardial infarction (in the acute stage);
• arterial hypertension ;
• hypertrophic subaortic stenosis ;
• systemic lupus erythematosus ;
• violations of water-salt metabolism (hypocalcemia, hypochloremia, hypomagnesemia, etc.);
• pancreatitis ;
• digitalis intoxication (intoxication caused by the intake of cardiac glycosides).

Relative contraindications to the use of Furosemide:

• benign prostatic hyperplasia (BPH);
• diabetes ;
• hypoproteinemia (when taking the drug, the risk of developing ototoxicity increases);
• obliterating cerebral atherosclerosis ;
• hepatorenal syndrome ;
• hypotension in patients at risk of ischemia (coronary, cerebral or otherwise), which is associated with circulatory failure;
• hypoproteinemia on the background nephrotic syndrome (it is possible to increase the undesirable side effects of Furosemide (especially ototoxicity) and reduce its effectiveness).

Patients at risk should be under constant medical supervision. Violation of the KShchR, hypovolemia or dehydration are grounds for reviewing the treatment regimen and, if necessary, temporarily discontinuing the drug.

Diuretics contribute to the excretion of sodium from the body, therefore, in order to avoid the development hyponatremia before starting therapy and subsequently throughout the entire course of Furosemide, it is necessary to control the sodium level in the patient's blood (especially in patients with cachexia , cirrhosis as well as in the elderly).

Application loop diuretics may cause sudden hypokalemia . The risk group includes:

• aged people;
• patients who are not receiving adequate nutrition and / or taking several drugs at the same time;
• patients diagnosed with cirrhosis with ascites ;
• patients with heart failure .

hypokalemia raises cardiotoxicity of digitalis preparations (Digitalis) and risk cardiac arrhythmias . At long QT interval syndrome (congenital or drug-induced) hypokalemia contributes to the emergence bradycardia or potentially life-threatening torsades de pointes .

In diabetics throughout the course of treatment, it is necessary to systematically monitor the level of sugar.

Additional Information

The drug is not doping, but it is often used to remove prohibited substances from the body, as well as a means of losing weight in sports where the weight of the athlete is important. In this regard, Furosemide is equated to doping drugs and cannot be used in athletes.

Side effects of furosemide

Against the background of the use of the drug, the following side effects may occur:

• cardiovascular disorders , including orthostatic hypotension , arterial hypotension , arrhythmias , tachycardia , collapse ;
• dysfunctions of the nervous system manifested by dizziness, muscle weakness, headache, tetany , apathy , adynamia , paresthesia , drowsiness, lethargy, weakness, confusion;
• sensory dysfunction (in particular, hearing and vision impairments);
• disorders of the digestive system, including dry mouth, anorexia , cholestatic jaundice diarrhea/constipation, nausea, vomiting, exacerbation of pancreatitis ;
• disorders of the urogenital tract, including oliguria , interstitial nephritis , acute urinary retention (with BPH), hematuria , impotence ;
• hypersensitivity reactions, including exfoliative dermatitis , hives , purpura ,necrotizing angiitis , vasculitis , erythema multiforme , chills, pruritus, photosensitivity, fever , anaphylactic shock ;
• disorders of the hematopoietic organ system, including aplastic anemia , thrombocytopenia , leukopenia , agranulocytosis ;
• disorders of water-salt metabolism, including dehydration and, as a result, an increased risk thrombosis/thromboembolism , hypovolemia , hypomagnesemia , hypochloremia , hypokalemia ,hypocalcemia , hyponatremia , metabolic acidosis ;
• changes in laboratory parameters, including hypercholesterolemia , hyperglycemia , glycosuria , hyperuricemia .

When furosemide is administered intravenously, it may develop thrombophlebitis and in newborn babies kidney calcification .

Instructions for use Furosemide

How to take Furosemide for swelling?

Diuretic tablets take inside. The doctor selects the dose individually, depending on the indications and the characteristics of the course of the disease.

An adult with edema that has developed against the background of pathologies of the liver, kidneys or heart is prescribed to take ½-1 tablet / day, if the condition is assessed as moderate. In severe cases, the doctor may recommend taking 2-3 tablets. 1.r./day or 3-4 tab. in 2 doses.

How to lower blood pressure with Furosemide?

To reduce elevated blood pressure in patients with chronic renal failure, the drug is used in combination with antagonists of the renin-angiotensive system. The recommended dose varies from 20 to 120 mg/day. (½-3 tablets / day). The medicine is taken in one or two doses.

Furosemide for weight loss

Some women use the properties of the drug for weight loss. Taking Furosemide tablets (Furosemide Sopharma) really allows you to get rid of several kilograms, but this weight loss can hardly be called weight loss, since the drug does not remove excess fat in problem areas, but only removes water from the body.

Application instruction of Furosemide in ampoules

The preferred method of administering the solution is by slow intravenous injection (performed within 1-2 minutes).

The drug is administered into the muscle in exceptional cases, when the oral or intravenous route of administration is not possible. Contraindications for intramuscular administration of Furosemide are acute conditions (for example, pulmonary edema ).

Taking into account the clinical condition of the patient, it is recommended to transfer from the parenteral to the oral route of administration of Furosemide as soon as possible.

The question of the duration of treatment is decided taking into account the nature of the disease and the severity of the symptoms. The manufacturer recommends using the lowest possible dose at which the therapeutic effect will be maintained.

At edematous syndrome in adults and adolescents over 15 years of age, treatment begins with the introduction into a vein (in exceptional cases, into a muscle) of 20-40 mg of Furosemide.

In the absence of a diuretic effect, the drug is continued to be administered every 2 hours at a dose increased by 50%. Treatment according to this scheme is continued until adequate diuresis is achieved.

A dose greater than 80 mg should be administered by drip into a vein. The rate of administration should not exceed 4 mg/min. The maximum allowable dose is 600 mg / day.

In case of poisoning, to maintain forced diuresis, the patient should be administered from 20 to 40 mg of the drug, after dissolving the required dose in the infusion solution of electrolytes. Further treatment is carried out depending on the volume of diuresis. It is obligatory to replace the salts and fluids lost by the body.

Starting dose at hypertensive crisis - 20-40 mg. In the future, it is adjusted taking into account the clinical response.

Furosemide injections and tablets: instructions for use in children

In pediatrics, the dose is selected depending on the weight of the patient. Furosemide in tablets is given to a child at the rate of 1-2 mg / kg / day. The dose can be taken in one dose or divided into two doses.

The questions of how often you can drink the drug in a particular case, as well as how long the course of treatment will be, can only be answered by the attending physician. Only recommendations on what to take Furosemide with are unequivocal: as an addition to diuretics, you should definitely drink potassium preparations.

Intravenously for children under 15 years of age, the drug is administered at a dose of 0.5-1.5 mg / kg / day.

Furosemide tablets: what are they used for in veterinary medicine?

Why is Furasemide Sopharma used in veterinary medicine? In veterinary practice, Furosemide and similar drugs are used as part of complex therapy for the treatment of heart pathologies in dogs.

The use of diuretics allows you to remove the fluid that accumulates around the lungs, abdominal or chest cavity, and thereby reduce the load on the heart.

For dogs, the dosage of Furosemide depends on the weight of the animal. As a rule, the drug is given 2 times a day at the rate of 2 mg / kg. As an adjunct to treatment, it is recommended that the dog be given bananas daily (one per day) to compensate for potassium losses.

Overdose

Furosemide overdose symptoms:

• a sharp drop in blood pressure;
• hypovolemia ;
• dehydration;
• collapse ;
• hemoconcentration ;
• arrhythmias (including atrioventricular block and fibrillation (flicker) of the ventricles);
• thrombosis ;
• thromboembolism ;
• confusion;
• drowsiness;
• arrester with anuria ;
• apathy;
• flaccid paralysis.

To normalize the patient's condition, measures are prescribed aimed at correcting the CSR and water-salt metabolism, replenishing the BCC deficiency. Further treatment is symptomatic.

Furosemide has no specific antidote.

Interaction

Furosemide increases concentration and toxicity (in particular, oto- and nephrotoxicity) Ethacrynic acid , Aminoglycosides , Cephalosporins , Cisplatin , Chloramphenicol , Amphotericin B .

Enhances therapeutic efficacy Theophylline And Dazoxide , reduces efficiency Allopurine And hypoglycemic drugs .

Reduces the rate of renal excretion of Li + drugs from the blood, thereby increasing the likelihood of intoxication with them.

Enhances induced by non-depolarizing muscle relaxants (peripherally acting relaxants) neuromuscular blockade and action antihypertensive drugs , weakens the effect non-depolarizing relaxants .

In combination with pressor amines, there is a mutual decrease in the effectiveness of drugs, with Amphotericin B and GCS - increases the risk of developing hypokalemia .

Use in combination with cardiac glycosides (SG) can provoke the development of the toxic effects inherent in the latter due to a decrease in the level of potassium in the blood (for low- and high-polarity SGs) and an extension of the half-life (for low-polarity SGs).

Drugs that block tubular secretion increase the serum concentration of furosemide.

Sucralfate and NSAIDs reduce the diuretic effect of the drug due to the suppression of Pg synthesis, changes in plasma concentration renin and allocation aldosterone .

The use of high doses salicylates against the background of drug treatment increases the risk of manifestation of their toxicity, which is due to competitive renal excretion of drugs.

The Furosemide solution injected into a vein has a slightly alkaline reaction, so it is contraindicated to mix it with drugs whose pH is below 5.5.

Furosemide intravenously within 24 hours of chloral hydrate can cause:

• nausea;
• flushes of blood;
• anxiety;
• increased sweating;
• increase in blood pressure;
• tachycardia.

The use of Furosemide with ototoxic agents (for example, with aminoglycosides ) can cause irreversible hearing loss . Such a combination can only be used for health reasons.

Terms of sale

A prescription is required to purchase the solution and tablets.

Furosemide recipe in Latin:

Rep.: Tab. Furosemidi 0.04 N.10

Storage conditions

Store the drug in a light-protected place at temperatures up to 25 ° C.

Best before date

special instructions

Against the background of course treatment, a blood ionogram should be periodically done, as well as control of acid-base balance, blood pressure, uric acid, creatinine, residual nitrogen, and liver function. If necessary, the treatment regimen is revised taking into account these indicators.

In the case of high doses of Furosemide, it is not recommended to limit the intake of dietary salt, which is associated with the risk of developing metabolic acidosis And hyponatremia .

In patients with BPH, hydronephrosis , narrowing of the ureters , and in patients who are unconscious, urine output should be monitored due to the possibility of acute urinary retention.

The tablet form of the drug is contraindicated in people with syndrome of impaired absorption of glucose / galactose, congenital galactosemia, hypolactasia .

How to replace Furosemide?

Furosemide analogs in tablets: Furosemide Sopharma , Lasix .

Analogues of the parenteral form of the drug: Furosemide-Darnitsa , Furosemide-Vial , Lasix .

Drugs belonging to the same pharmacological subgroup as Furosemide: Bufenox , Britomar , Diuver , Trigrim , Torasemide .

Which is better - Lasix or Furosemide?

Lasix is one of the trade names for furosemide. The drug is produced by the Indian company Sanofi India Ltd. and, like its analogue, has two dosage forms: a one-percent solution for injection and tablets of 40 mg.

Thus, when choosing one or another means, one should be guided by subjective feelings. The advantage of Furosemide is its lower price.

furosemide and alcohol

Alcohol is contraindicated in patients taking Furosemide.

Furosemide for weight loss

There is a lot of advice on the Internet about how to use diuretics for weight loss. One of the most affordable drugs in this group is Furosemide.

What does the medicine help? According to the instructions, Furosemide is used for ascites , edematous syndrome , hypertension . Thus, the manufacturer does not report anything regarding the possibility of using diet pills.

However, many women note that with the help of this tool they were able to lose a few kilograms quite quickly (in some cases, up to 3 kg per night). However, it is impossible to regard such weight loss as weight loss: the action of the drug is aimed at removing excess fluid, and by no means at breaking down fat.

Why is furosemide dangerous?

Application diuretics for weight loss can cause serious health problems, because removing water, these drugs also upset the balance of electrolytes in the body. one of the most common side effects is hypokalemia .

Potassium deficiency, in turn, leads to muscle cramps, weakness, visual disturbances, sweating, loss of appetite, nausea, and dizziness.

A very dangerous side effect is arrhythmia . SOLVD studies have shown that treatment loop diuretics accompanied by an increase in mortality among patients. At the same time, both overall and cardiovascular mortality, as well as the number of sudden deaths, are increasing.

Another danger that can be caused by uncontrolled use diuretics for weight loss, is a violation of the kidneys. Moreover, it may take more than one month to restore the function of the kidneys and lymphatic system.

How to take Furosemide for weight loss?

To remove a few extra pounds, women usually take 2-3 (no more!) Furosemide tablets during the day with an interval of three hours between doses, and then 2 more tablets at night.

You can repeat the one-day course no earlier than in 2-3 days.

Furosemide and Asparkam for weight loss

Since one of the side effects of Furosemide is hypokalemia , it is very important to follow a certain diet while using this drug (meaning the use of foods high in potassium) or to additionally take medicines that can minimize the inherent diuretics side effects.

As a rule, Furosemide is recommended to be taken in combination with Asparkam (Panangin) . What's happened Asparkam ? This is a drug that is used as an additional source of potassium and magnesium. The drug has a harmless composition, which eliminates the possibility of its undesirable interaction with Furosemide.

Recommendations on how to drink with Asparkam diuretic drugs only a doctor can give. Tablets Asparkama , according to the manufacturer's instructions, take 3-6 pieces per day, dividing the indicated dose into three doses.

How often can Furosemide be taken for weight loss?

Optimal - never. In extreme cases, it is allowed to use the drug as a means of emergency care when you need to urgently remove swelling.

Reviews of women who have tried to lose weight on Furosemide indicate that taking more than 2 tablets per week is always accompanied by side effects. In addition, another problem often appears - how to “get off” the drug.

Can Furosemide be taken during pregnancy?

When asked if pregnant women can take diuretics , most doctors give the answer that for treatment preeclampsia And preeclampsia modern medicine offers much safer methods.

That is, Furosemide during pregnancy can only be used as an ambulance, as short a course as possible, and only on condition that the woman is under strict medical supervision.

According to the FDA classification, the drug belongs to category C.

Despite all the contraindications, on the forums, women quite often leave feedback on the use of Furosemide during pregnancy.

In almost all of them, it is noted that the drug really quickly removed excess fluid from the body, but at the same time it also causes unpleasant side effects (for example, leg cramps).

Therefore, all mothers are unanimous in their opinion - Furosemide can be taken only according to strict indications and only in an uncontested situation.

Application for lactation

Furosemide penetrates into milk and is able to suppress lactation, therefore its use in lactating women is possible only if the child is transferred to artificial feeding during the treatment of the mother.

Reviews about Furosemide

Furasemide is one of the most effective diuretics fast and short action.

Reviews of doctors confirm the fact that the drug plays a key role in the treatment edematous syndrome in patients with heart failure , insofar as loop diuretics most effectively block the reabsorption of Na + ions in the ascending segment of the loop of Henle. At the same time, Furosemide retains its activity even in patients with chronic renal failure (including those at the terminal stage of the disease).

However, the application loop diuretics short-acting may cause irreversible damage to the renal tubules, especially in cases where the drug is administered in high doses.

Parallel increase in the delivery of Na + ions to the distal parts of the nephron, where they no longer act loop diuretics , leads to sodium overload and structural damage to these parts of the nephron with the development hyperplasia And hypertrophy .

In addition, after the completion of the action of the drug, the reabsorption of Na + increases significantly and, as a result, the “rebound” effect develops, which is manifested by an increase in postdiuretic reabsorption.

The reviews that patients leave allow us to conclude that the medicine helps well with edema and is indispensable for hypertensive patients. The disadvantages of the drug, as a rule, are called side effects, contraindications and the fact that it is addictive.

Another category of reviews is reviews of Furosemide for weight loss. Despite the fact that the drug really allows you to quickly reduce weight by 3-5 kg, both doctors and those who are losing weight do not recommend using it for weight loss. This is due to the fact that the drug does not remove excess fat, but only removes water (and with it the substances necessary for the body to function normally).

Thus, given that Furosemide is a very powerful tool, it can be used only subject to contraindications, without exceeding the prescribed dose and only under the supervision of a doctor (especially during pregnancy). Also, you should not take it for other purposes (for example, when cystitis ).

During treatment diuretics very important is the question - with what to drink the drug. It is optimal to supplement therapy with the use of potassium-rich foods or taking potassium supplements.

How much do the tablets cost and how much can I buy a solution of Furosemide?

The price of Furosemide in injectable form in Ukraine is from 14 UAH. The price of Furosemide in tablets is from 5.5 UAH.

The price of Furosemide diuretic tablets in Russian pharmacies is from 15 rubles. The price of ampoules is from 22.5 rubles.

Furosemide, what do these pills help with? The drug is well known for its diuretic properties, allowing you to remove puffiness. The diuretic "Furosemide" instruction for use prescribes to take with edema, heart failure, hypertension.

Composition and form of release

The drug is produced in the form of tablets for internal use, as well as a solution for injection. The active element of the drug "Furosemide", from which it helps with edema, is the substance of the same name. Diuretic tablets include 0.04 g of the active substance, injections contain 10 mg / ml.

Injections are supplied in 2 ml ampoules. Auxiliary components contribute to better absorption of the drug, the list of which depends on the form of release: starch, silicon dioxide, sodium hydroxide, magnesium stearate, sodium chloride, povidone and other components.

Pharmacological properties

Diuretic tablets "Furosemide", from which the medicine helps with kidney diseases, intensively remove water and magnesium and calcium ions from the body. Thus, the diuretic effect of the active element is manifested. When using the remedy for heart failure, the load on the myocardium decreases.

This occurs as a result of the expansion of arteries and veins. The action of the drug is observed after 5 minutes with intravenous injection and an hour later when using tablets. The therapeutic effect lasts for 2-3 hours. With a deterioration in kidney function, the drug acts for 6-8 hours.

The drug "Furosemide": what helps

The drug is prescribed for various types of edematous syndrome. Indications for the use of the drug "Furosemide" include the following diseases and conditions:

heart asthma; excess calcium in the body; pulmonary edema; hypertensive crisis; heart failure; eclampsia; swelling of the brain; complicated arterial hypertension; nephrotic syndrome; cirrhosis of the liver.

The drug is also used when performing forced diuresis.

What helps "Furosemide" in ampoules

The instruction explains that the indications for the use of the injection form are similar to tablets. However, injections work faster. To the question: “What is the Furasemide solution for?”, Physicians answer that intravenous administration can quickly reduce pressure and preload on the myocardium. This plays an important role in emergency conditions of the patient.

Contraindications

The drug "Furosemide" instructions for use prohibits the use of:

hypersensitivity to the active element; stenosis of the urethra; arterial hypotension; digitalis intoxication; pancreatitis; acute glomerulonephritis; hypokalemia; diabetic coma; increased venous pressure; acute kidney failure; hepatic coma; gout; cardiomyopathy; urinary tract stones; liver failure in a complex form; hyperglycemic coma; hyperuricemia; aortic stenosis; alkalosis; precomatose states; acute myocardial infarction.

Caution when using the product should be observed by persons aged, with diabetes mellitus, prostate hyperplasia, hypoproteinemia, atherosclerosis. Furosemide during pregnancy and breastfeeding can only be used as an emergency aid under the supervision of a physician.

Medicine "Furosemide": instructions for use

The treatment regimen is determined by a specialist depending on the clinical picture of the pathology. Tablets are taken in a volume of 20 to 80 mg per day. The dosage can be gradually increased, bringing the daily use of the drug to 0.6 g. The amount of the drug "Furosemide" for children is calculated based on body weight 1-2 mg per kg, not more than 6 mg per kg.

Instructions for the use of injections "Furosemide"

The volume of intramuscular or intravenous injections should not exceed 0.04 g per day. Doubling the dose is possible. Doctors recommend injecting the drug into a vein infectiously for 2 minutes. It is possible to inject injections into muscle tissue only if it is impossible to use tablets and intravenous injections.

In acute conditions, injections into the muscle are contraindicated.

Drug interaction

The combined use of the drug "Furosemide" and other drugs can cause negative reactions of the body. The combination of the drug with hypoglycemic drugs, cephalosporins, aminoglycosides, indomethacin, NSAIDs, insulin is unacceptable. Do not take the drug together with digitoxin, astemizole, digoxin, ACE inhibitors, cisplatin, cholestyramine, cisapride, phenytoin, colestipol, lithium carbonate.

Side effects

The drug "Furosemide", reviews and instructions confirm this, it can cause negative reactions in the body. Side effects include:

tachycardia, dizziness, hearing impairment; anorexia, oliguria, exfoliative dermatitis; aplastic anemia, dehydration, thrombophlebitis; orthostatic hypotension, muscle weakness; visual disturbances, dry mouth; interstitial nephritis, urticaria; thrombocytopenia, metabolic acidosis; kidney calcification (in newborns); arrhythmia, headache, cholestatic jaundice; hematuria, pruritus, hypochloremia; low blood pressure, tetany, stool disorders; urinary retention, purpura, leukopenia; hyponatremia, collapse, apathy; nausea or vomiting, lethargy, impotence; necrotizing angiitis, agranulocytosis; hypovolemia, confusion; exacerbation of pancreatitis, vasculitis; anaphylactic shock, weakness, drowsiness, erythema.

Price and analogues

Furasemide can be replaced by the following drugs - analogues: Lasix, Torasemide, Trigrim, Furosemide Sopharma. You can buy Furosemide tablets for 16-20 rubles, the price of injections is 25 rubles.

Opinions of patients and doctors

The drug "Furosemide", reviews of experts confirm this fact, is a key tool for the treatment of edematous syndrome in people with heart failure. This is a fast acting drug. Patients say that in addition to helping with edema and hypertension, the medication has side effects and is addictive (it is undesirable to use it for a long time).

Many women use the medicine "Furosemide" for weight loss. This tool allows you to quickly get rid of 3 - 5 kg of excess weight. However, for weight loss, doctors do not advise taking the drug, because it does not break down excess fat, but removes water and other necessary substances. Women claim that when taking more than 2 capsules per week, side effects and addiction appear.

On the forums you can meet the question: Which is better - "Lasix" or "Furosemide"? The pharmacists explain that the drugs are identical and their choice depends on price and availability.

Stagnation, swelling of soft tissues are quite common disorders that occur in many diseases of various organ systems. It is possible to improve the outflow and exit of fluid from the body with the help of drugs, of which there are a huge variety today. And quite often, doctors recommend the drug "Furosemide" to their patients. What does he help? What properties does it have? Are there any contraindications to treatment? Is it possible for side effects to occur? The answers to these questions are of interest to every patient.

The composition and form of release of the drug

The diuretic "Furosemide" is available in the form of tablets, as well as a solution for intravenous or intramuscular administration. There are also granules for the preparation of a suspension - this form of medicine is more suitable for the treatment of children.

The main active substance of the drug is furosemide. One tablet contains 40 mg of this component. In the pharmacy you can buy packs of 20 or 50 tablets. In some cases (especially when it comes to severe edema), it is advisable to use an injection solution - it is sold in 2 ml glass ampoules with a furosemide concentration of 1%. To date, packages of 10, 25 and 50 ampoules are sold.

In fact, in almost every pharmacy you can easily buy the drug "Furosemide". A prescription from a doctor for pills is not needed in this case, although some pharmacies have sales restrictions.

Main pharmacological properties

In modern medicine, the medicine "Furosemide" is very often used. Its use in some cases is simply necessary. This is a fast-acting diuretic that inhibits the reabsorption of chloride and sodium ions in the proximal and distal tubules of the kidney, which accelerates the process of excretion of their body fluid. The drug does not affect glomerular filtration in any way, so it is prescribed even in the presence of renal failure. Furosemide also dilates peripheral vessels, which reduces blood pressure.

After taking the pill, the effect, as a rule, begins to appear after 30-50 minutes. If we are talking about intravenous administration, then an increase in the volume of urine released begins after 15-20 minutes. The effect of the drug lasts about 3-4 hours.

The drug "Furosemide": what is it taken from? Indications for therapy

Everyone experiences health problems from time to time. So in what cases is it advisable to take the drug "Furosemide"? What does he help? The main indication for admission is edematous syndrome. In turn, edema can be a symptom of a variety of diseases.

Of course, often the stagnation of fluid indicates the presence of problems with the kidneys. In such cases, doctors often prescribe Furosemide. Indications for use - edema that has arisen against the background of chronic renal failure, nephrotic syndrome, hypercalcemia. In addition, the drug helps with hypertension, chronic heart failure, eclampsia, cardiac asthma. Also, the medicine helps fight swelling, which is associated with liver diseases. Indications also include pulmonary and cerebral edema.

The drug "Furosemide": instructions

These tablets, as mentioned earlier, can be freely bought at the pharmacy. If you have any problems, however, you should first consult a doctor. Only a specialist can prescribe you the drug "Furosemide". How to take pills, what is the maximum daily dose, how long will the treatment last - you will find answers to all these questions from your doctor. The instructions for use contain only general recommendations.

As a rule, the initial dose of the drug for adults is 40 mg of furosemide (one tablet). If there are no changes after taking the medicine, the doctor can increase the dose by 80-120 mg every 6-8 hours until a normal diuretic effect appears. However, there are some restrictions. No more than four tablets (160 mg) can be taken at a time. The maximum daily dose is 300 mg, but in such quantities the drug cannot be used for maintenance therapy, only as an emergency measure.

Often, patients suffering from edema and arterial hypertension are prescribed the drug Furosemide. How to take it in such cases? Most often, doctors recommend drinking one tablet twice a day. The duration of therapy is determined individually. As soon as the swelling begins to disappear, the dose of the drug is gradually reduced.

Intravenous and intramuscular administration is advisable only for persistent edema, as well as in cases where oral administration is not possible. If we are talking about the treatment of children, then the daily dose is 1-2 mg of furosemide per kilogram of weight.

Doctors often prescribe Furosemide (tablets) to their patients. The instructions for use contain some specific recommendations. Against the background of a long-term course of taking the drug, it is very important to control blood pressure all the time, as well as monitor the concentration of electrolytes in the plasma. Also, some patients are advised to take potassium supplements and eat a diet rich in this and other minerals.

Are there contraindications?

Many people are interested in the question of whether all categories of patients are allowed to take the drug "Furosemide" (tablets). Instructions for use confirms that there are some contraindications in this case. Each patient should familiarize themselves with their list even before the start of therapy.

To begin with, it is worth saying that the drug is not prescribed to a patient with hypokalemia, since the tablets can further reduce the level of potassium in the blood, which will affect the work of the whole organism, especially the cardiovascular system. Contraindications also include hypersensitivity to any of the components of the drug, lactose intolerance, lactase deficiency and wheat allergy.

The drug should not be prescribed in the presence of severe renal or hepatic insufficiency, hepatic coma. Also, contraindications include acute glomerulonephritis, in which there is a violation of the outflow of urine. The drug should not be taken by patients with impaired water and electrolyte balance, decompensated aortic and mitral stenosis, increased venous pressure, hypertrophic obstructive cardiomyopathy. The tablets are not intended for the treatment of children under the age of three.

Many people need to take the drug Furosemide. Indications for therapy are most often puffiness, and it is no secret to anyone that many pregnant women face a similar problem. It is immediately worth noting that taking this medication in the first trimester is strictly prohibited. In the second half of pregnancy, therapy is possible, but only under medical supervision. By the way, during lactation, the drug affects the functioning of the mammary glands, causing a decrease in the amount of milk (due to the removal of fluid). If therapy is still necessary, then it is better to stop breastfeeding for the duration of treatment.

Main Side Effects

Many people are interested in questions about what Furosemide is, what it is used for, etc. But no less important aspect is the presence of side effects. Statistical studies have shown that complications in most cases are the result of incorrect or too long medication. If you follow all the doctor's recommendations, the likelihood of side effects is minimal.

Against the background of therapy, hypotension, interstitial nephritis may develop. It is also possible to reduce the level of potassium in the blood, increase the level of glucose and uric acid, which is associated with increased diuresis. Sometimes there are reactions from the digestive (nausea, vomiting) and nervous systems (dizziness, headaches, fatigue, depression, confusion). It is also possible the appearance of strong thirst, dryness of the mucous membranes. Some patients develop allergic skin reactions.

Interaction with other drugs

Diuretic "Furosemide" is not recommended to be taken together with cephalosporins, ethacrynic acid, amphotericins and other drugs that have a nephrotoxic effect. This drug also increases the activity of theophylline and diazoxide, reduces the effect of allopurinol, non-depolarizing muscle relaxants. Be sure to tell your doctor about all medications you are taking. During therapy, it is strictly forbidden to drink alcohol.

Overdose and its consequences

Today, many patients are faced with the need to take the drug "Furosemide". Indications for its use are swelling and stagnation of fluid, which, alas, some people encounter very often. Unfortunately, too high doses of this drug can lead to dangerous consequences, in particular, hypovolemia, a condition that is accompanied by a decrease in circulating blood volume. Against the background of such a disorder, a sharp decrease in blood pressure is possible, as well as orthostatic collapse. The patient after an overdose urgently needs to be taken to the hospital. First of all, he needs to enter an electrolyte solution in order to restore blood volume. If necessary, further symptomatic therapy is carried out.

How much does the medicine cost?

So, we found out what the instruction tells about the drug "Furosemide". Tablets, their composition and properties are certainly very interesting. But no less important factor for many is the price of the medicine.

So how much will the drug cost? In fact, Furosemide stands out among other diuretics not only for its high efficiency, but also for its affordable cost. A package of 50 tablets with a dose of the active substance of 40 mg costs about 30-40 rubles. But 10 ampoules of this medicine will cost 25-30 rubles, which, you see, is not so much. Of course, the figure may vary depending on the city of residence of the patient, the pharmacy, the services of which he decided to use, and many other factors.

Drug analogues

In some cases, for a number of reasons, this or that medicine is not suitable for patients. Therefore, many are interested in whether it is possible to replace Furosemide with something. Analogues of this drug, of course, exist. The modern pharmaceutical market offers a huge selection of diuretics.

For example, Lasix is ​​considered a pretty good substitute. Also, the doctor may recommend taking drugs such as Furon or Frusemide. These are structural analogues that contain the same active substance and, accordingly, have a similar effect.

There are other diuretics that contain different ingredients but provide the same effect. Doctors often prescribe to their patients drugs such as "Urea", "Mannitol", "Trifas", "Clopamide", "Uregit". These are quite strong drugs that help to quickly solve the problem with edema. There are milder agents, the list of which includes Cyclomethiazide, Hypothiazid, Pterofen, Diakarb, Veroshpiron.

In any case, it should be understood that you cannot independently look for a substitute for the drug Furosemide. Analogues can only be selected by the attending physician, since here everything depends on the patient's state of health, his age, the characteristics of the disease and individual needs. Uncontrolled intake of diuretics can lead to dangerous consequences.