Normal human immunoglobulin.

Human normal is a drug that is made from donated blood (its plasma). Immunoglobulin itself is a protein that is responsible for the body's immune response to the penetration of foreign factors (bacteria, viruses, fungi, and so on). Simply put, these are antibodies - the main link of specific protection, distributed in human blood. In its properties, human normal immunoglobulin is practically identical to immunoglobulin type G (IgG), which determines long-term humoral (that is, carried out in body fluids) immunity. Also, this drug has a non-specific effect, showing anti-inflammatory and restorative activity.

Indications for the introduction of human normal immunoglobulin are a variety of conditions associated with the suppression of the body's own defense systems. Firstly, this remedy can be used in replacement therapy, that is, to replace absent or extremely weakened immunity in immunodeficiencies. Such pathologies include HIV, congenital or acquired agammaglobulinemia, condition after bone marrow transplantation, and so on. Secondly, the positive effect of Human Normal Immunoglobulin is observed in: various infectious and inflammatory acute and chronic diseases, immunosuppression due to prolonged use of a certain drug, autoimmune diseases, and many, many others.

Normal human immunoglobulin is produced for intramuscular and intravenous administration - and the first type of the drug should never be injected into a vein. The instruction of the drug describes the basic principles by which the treatment is carried out. For example, an intravenous form of Immunoglobulin should be administered slowly through a dropper, diluting it into saline. The concentration of the solution of this drug can be from 3 to 12 percent - but never higher! In general, the main thing that should be understood from this annotation: Normal human immunoglobulin is never used on its own - without the exact instructions of a doctor.

Contraindications for use, side effects and overdose of Human Normal Immunoglobulin

Do not administer this drug to patients with intolerance to blood products, as well as if he has antibodies to immunoglobulin A (IgA) in his blood. Carefully, only after consultation with the relevant specialists, Immunoglobulin is prescribed for dysfunctions of the heart, kidneys, diabetes mellitus, migraines, acute allergic process, during childbearing and feeding.

This drug has an extensive systemic effect. Usually, subject to all the rules of injections and infusions, it is normally tolerated by the patient's body. But complications can affect the work of all systems - digestive, nervous, cardiovascular. The most dangerous and rare phenomenon is necrosis (necrosis) of the renal tubules. It is worth remembering that any administration of Immunoglobulin can cause anaphylactic shock or other allergic reactions, even if previous injections have gone without complications.

With an overdose, the likelihood of side effects increases, blood viscosity and volume increase.

Immunoglobulin during pregnancy

Human normal immunoglobulin should not be confused with anti-D-immunoglobulin, which is administered to a pregnant woman with the possibility of a Rh conflict. These are different drugs.

Reviews about human normal immunoglobulin

Often, this drug is prescribed to pregnant women who have found herpes, cytomegalovirus or other infectious diseases that can disrupt the development of the fetus. But even the opinions of experts on this matter are extremely contradictory: someone considers the danger from the introduction of this agent more obvious than from the described viruses (especially if only antibodies to them are found in the blood). So the reviews about Human Normal Immunoglobulin are replete with concerns about such appointments.

Most of them are trying to collect as much information as possible about the consequences of treatment with Immunoglobulin, and somehow generalize it, coming to the only conclusion: to inject / not to inject ... But this, alas, is impossible. There are an infinite number of examples of ANY of the possible developments of the situation. And for every argument "for" there will be an argument "against".

Perhaps one thing can be advised: if an active form of a virus or other infectious agent is not found in your blood, there are no M (IgM) antibodies that are formed just at the beginning of the infectious process, but only G (IgG) antibodies that are responsible for long-term immunity - do not rush to experience the effect of Immunoglobulin. And be sure to consult several immunologists with a good reputation about this.

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normal human immunoglobulin

Instructions for use

Normal human immunoglobulin, solution for intravenous administration.

The drug is a highly purified preparation of immunoglobulin 0, isolated from the blood plasma of healthy donors, individually tested for the absence of hepatitis B surface antigen (HBs Ag) and antibodies to hepatitis C virus and human immunodeficiency viruses HIV-1 and HIV-2.

1 ml of the drug contains immunoglobulin 50 mg, glucose 10 mg, glycine 5 mg and sodium chloride 7 mg. Protein concentration from 4.5 to 5.5%.

The drug has low anticomplementary activity, does not contain preservatives and antibiotics.

Clear or slightly opalescent colorless liquid.

immunological properties.

The active component of the drug are immunoglobulins with the activity of antibodies of various specificities. The drug also has non-specific activity, which manifests itself in increasing the resistance of the organism.

Appointment.

Treatment of severe forms of bacterial and viral infections, postoperative complications accompanied by septicemia in children and adults.

Method of application and dosage.

For children, a single dose of the drug is 3-4 ml per 1 kg of weight, but not more than 25 ml. Immediately before administration, the drug is diluted with isotonic 0.9% sodium chloride solution for injection or 5% glucose solution for injection at the rate of 1 part of the drug and 4 parts of the dilution solution. Diluted immunoglobulin is injected intravenously at a rate of 8-10 drops per minute. Infusions are carried out daily for 3-5 days.

For adults, a single dose of the drug is 25-50 ml.

Immunoglobulin (without additional dilution) is administered intravenously at a rate of 30-40 drops per minute. Faster administration may cause the development of a collaptoid reaction. The course of treatment consists of 3-10 transfusions carried out after 24-72 hours (depending on the severity of the disease).

The drug is used only in a hospital, subject to all the rules of asepsis. Before the introduction, the bottles are kept at a temperature of 18 to 22 ° C for at least 2 hours. Turbid and sediment-containing solutions should not be used.

Transfusion therapy with intravenous immunoglobulin may be combined with the use of other drugs.

Side effects.

Reactions to the introduction of immunoglobulin, as a rule, are absent. Individuals with altered reactivity may develop allergic reactions of various types, and in extremely rare cases, anaphylactic shock, and therefore persons who have received the drug should be under medical supervision. In the room where the drug is administered, anti-shock therapy must be available.

Interaction with other drugs.

Not installed.

Contraindications.

Immunoglobulin is not administered to persons with a history of allergic reactions to blood products. (In cases of severe sepsis, the only contraindication for administration is a history of anaphylactic shock to blood products). For persons suffering from allergic diseases (bronchial asthma, atopic dermatitis, recurrent urticaria) or prone to allergic reactions, the drug is administered against the background of antihistamines. It is recommended to continue their administration within 8 days after the end of the course of treatment. In the period of exacerbation of the allergic process, the introduction of the drug is carried out at the conclusion of the allergist according to vital indications.

For persons suffering from diseases in the genesis of which immunopathological mechanisms are the leading ones (systemic connective tissue diseases, immune blood diseases, glomerulonephritis), the drug is prescribed after consulting an appropriate specialist.

The drug is used only as directed by a doctor.

The introduction of immunoglobulin is recorded in the established accounting forms indicating the batch number, date of manufacture, expiration date, manufacturer, date of administration, dose and nature of the reaction to the administration of the drug.

Name: Immunoglobulin (Immunoglobulinum)

Pharmacological effect:
The drug is considered an immunomodulatory and immunostimulating agent. It contains a large number of neutralizing and opsonizing antibodies, thanks to which it is well resistant to viruses, bacteria and other pathogens. Also, the drug replenishes the number of missing IgG antibodies, thereby reducing the risk of infection in people with primary and secondary immunodeficiency. Immunoglobulin well replaces and replenishes natural antibodies in the patient's serum.

With intravenous administration, the bioavailability of the drug is 100%. A gradual redistribution of the active substance of the drug takes place between the extravascular space and human plasma. Equilibrium between these media is achieved on average in 1 week.

Immunoglobulin - indications for use:

Also, the drug is used for:
- thrombocytopenic purpura of immune origin;
- severe bacterial infections such as sepsis (in combination with antibiotics);
- viral infections;
- prevention of various infectious diseases in premature infants;
- Guillain-Barré syndrome;
- Kawasaki syndrome (mainly in combination with standard l / c for this disease);
- neutropenia of autoimmune origin;
- chronic demyelinating polyneuropathy;
- hemolytic anemia of autoimmune origin;
- erythrocyte aplasia;
- thrombocytopenia of immune origin;
- hemophilia caused by the synthesis of antibodies to factor P;
- treatment of myasthenia gravis;
- prevention of habitual miscarriage.

Immunoglobulin - method of application:

Immunoglobulin - side effects:

The manifestation of effects is most likely at the first dose of the drug: within the first hour. It can be a flu-like syndrome - malaise, chills, high body temperature, weakness, headache.

The following symptoms also occur:
- respiratory system (dry cough and shortness of breath);
- digestive system (nausea, diarrhea, vomiting, stomach pain and increased salivation);
cardiovascular system (cyanosis, tachycardia, chest pain, flushing of the face);
- central nervous system (drowsiness, weakness, rarely symptoms of aseptic meningitis - nausea, vomiting, headache, photosensitivity, impaired consciousness, stiff neck);
- kidneys (rarely acute tubular necrosis, aggravation of renal failure in patients with impaired renal function).

Allergic (itching, bronchospasm, skin rash) and local (hyperemia at the site of intramuscular injection) reactions are also possible. Other side effects include myalgia, joint pain, back pain, hiccups, and sweating.

In very infrequent cases, collapse, loss of consciousness and severe hypertension have been observed. In these severe cases, drug withdrawal is necessary. Administration of antihistamines, epinephrine, and plasma replacement solutions is also likely.

Immunoglobulin - contraindications:

With caution, the drug should be used for migraine, pregnancy and lactation, decompensated chronic heart failure. Also, if there are diseases in the genesis of which the main immunopathological mechanisms are (nephritis, collagenosis, immune blood diseases), then the drug should be prescribed with caution after the conclusion of a specialist.

Immunoglobulin - pregnancy:

With caution, you need to use the drug during lactation: it is known that it penetrates into mother's milk and contributes to the transfer of protective antibodies to the infant.

Interaction with other drugs:
The drug is considered pharmaceutically incompatible with other drugs. It should not be mixed with other medicines; for infusion, you should always use a separate dropper. With the simultaneous use of Immunoglobulin with active immunization agents for viral diseases such as rubella, chickenpox, measles, mumps, the effectiveness of treatment may decrease. If it is necessary to use parenteral live virus vaccines, they can be used after at least 1 month after taking Immunoglobulin. A more desirable waiting period is 3 months. If a large dosage of Immunoglobulin is administered, then its effect can last for a year. It is also forbidden to use this drug in conjunction with calcium gluconate in infants. There are suspicions that this will lead to negative phenomena.

Immunoglobulin - overdose:

Immunoglobulin - release form:

Immunoglobulin - storage conditions:

Immunoglobulin - synonyms:

Immunoglobulin - composition:

Immunoglobulin - optional:

The protective effect of this drug begins to appear 24 hours after ingestion, its duration is 30 days. In patients with a tendency to migraine or impaired renal function, increased caution should be exercised. You should also be aware that after using Immunoglobulin, there is a passive increase in the amount of antibodies in the blood. In serological testing, this can lead to misinterpretation of the results.

It is strictly forbidden to administer Immunoglobulin intravenously for intramuscular use. The rate of intravenous administration must not be exceeded, this threatens the development of collaptoid reactions.

From pharmacies, the drug is dispensed by prescription.

Important!
Before using the medicine Immunoglobulin you should consult your doctor. This manual is for informational purposes only.

Thanks

Immunoglobulins(antibodies, gamma globulins) are special compounds produced by cells of the immune system that protect a person from bacteria, viruses and other foreign substances (antigens).

Properties of immunoglobulins

The human immune system and its functions

Humoral immunity is that part of the immune system that performs its function in the liquid media of the human body. Those. antibodies do their job in the blood, interstitial fluids, and on the surface of mucous membranes.

There is also cellular immunity, carried out by a number of specialized cells (such as macrophages). However, it has nothing to do with immunoglobulins, and is a separate link in the defense.

The immune response may be:
1. specific.
2. Nonspecific.

Immunoglobulin carries out a specific immune response, finding and neutralizing foreign microorganisms and substances. Against each bacterium, virus or other agent, its own, monoclonal antibodies are formed (ie, capable of interacting with only one antigen). For example, anti-staphylococcal immunoglobulin will not help with diseases caused by other microorganisms.

Acquired immunity can be:
1. Active:

• formed due to antibodies formed after the disease;
• occurs after preventive vaccination (the introduction of weakened or killed microorganisms, or their modified toxins, in order to form an immune response).

• immunity in the fetus and newborn child, to whom maternal antibodies were transferred in utero, or during breastfeeding;
• occurs after a vaccination of ready-made immunoglobulins against a specific disease has been made.

Human immunoglobulin and its functions

• "recognizes" a foreign substance (a microorganism or its toxin);
• binds to an antigen, forming an immune complex;
• participates in the removal or destruction of the formed immune complexes;
• immunoglobulin against past diseases is stored in the body for a long time (sometimes for life), which protects a person from re-infection.

Antibodies are actively used in medicines. Currently, you can buy immunoglobulin in almost any pharmacy.

Immunity and immunoglobulins in children

• in utero, the child does not encounter microorganisms, so his own immune system is practically inactive;
• during pregnancy, only class G immunoglobulins can pass from mother to child, which freely cross the placenta due to their small size;
• detection of class M immunoglobulins in the blood serum of a fetus or a newborn child indicates an intrauterine infection. Often it is caused by cytomegalovirus (symptoms of the disease: runny nose, fever, swollen lymph nodes, damage to the liver and spleen, and others);
• Immunoglobulins acquired from the mother in the blood of an infant remain for about 6 months, protecting it from various diseases, therefore, in the absence of a pathology of the immune system, children practically do not get sick at this time.

Finally, the formation of the immune system in a child ends only by the age of 7. Distinctive features of the immunity of children are:
1. Insufficient ability to phagocytosis (absorption and destruction of cells of pathogenic microorganisms by human phagocytes).
2. Low production of interferons (proteins that provide nonspecific protection against viruses).
3. A decrease in the number of immunoglobulins of all classes (for example, for immunoglobulin E, the norm in children is lower than in adults).

Therefore, it is natural that in the process of the formation of the immune system of the body, the child often gets sick. To help him form immunity correctly, its increase should be achieved by means such as hardening, swimming and other sports activities, and being in the fresh air.

Immunoglobulins during pregnancy: Rhesus conflict

The mechanism for the development of this pathology is due to the fact that when a pregnant woman has a negative Rh - immunoglobulin can begin to be produced against the erythrocytes of the fetus. This usually happens in late pregnancy. The threat of Rhesus conflict increases with the pathology of pregnancy: inflammatory processes, the threat of interruption, increased uterine tone and others.

Rh incompatibility can lead to severe hemolysis (destruction of red blood cells) in the fetus and newborn. The consequences of this condition may be:

• severe hypoxia (oxygen starvation) of the fetus;
• violation of metabolic processes, intrauterine growth retardation;
• the appearance of edema, dropsy of the fetus;
• miscarriages and premature births, fetal death.

Anti-rhesus immunoglobulin during pregnancy

2. Prevention of the formation of "harmful" immunoglobulins during abortions or other manipulations that can lead to the entry of fetal serum into the mother's blood.

The price for anti-Rhesus immunoglobulin is quite high, but when it comes to the health of a pregnant woman and her child, you should not save. Lower cost distinguishes domestic analogues of drugs. Therefore, you can buy Russian-made anti-Rhesus immunoglobulin, especially since there are no differences in the mechanism of action of the funds.

Self-medication with drugs containing antibodies is contraindicated. During pregnancy, other drugs, with the exception of anti-Rhesus immunoglobulin, are not used.

Determination of the level of antibodies in the blood

Blood diseases and hypovitaminosis can also be the cause of immunodeficiency. The most common of these is iron deficiency anemiacharacterized by a low content of hemoglobin in red blood cells and a decrease in the amount of iron in the blood serum. This condition leads to oxygen starvation of tissues and, as a result, a decrease in immunity. Therefore, when hemoglobin is low, infectious diseases often occur. This is especially true for children, pregnant women or elderly patients.

Affinity and avidity of antibodies

The avidity of antibodies reveals the severity of the disease. For example, acute or recent (1-1.5 months ago) cytomegalovirus infection in children is confirmed by the detection of highly avid IgM antibodies, while their low concentrations can persist for up to two years.

Affinity indicates the strength of the interaction of antigens with antibodies. The higher the score, the better the antigens bind to antibodies. Therefore, a high affinity indicates a good immune response in the event of a given disease.

When is an immunoglobulin test prescribed?

• atopic dermatitis;
• food, drug allergies;
• some other states.

A blood test for immunoglobulin G is indicated in the following cases:

• diagnosis of immunodeficiency states;
• determining the presence of antibodies against a specific disease;
• monitoring the effectiveness of therapy with drugs containing immunoglobulin.

Analysis of fractions for the determination of class M antibodies is used to detect acute infectious diseases. It is often prescribed to detect cytomegalovirus infection, Epstein-Barr virus, Helicobacter pylori bacteria, which causes gastritis and stomach ulcers, and other infections. Normally, the total amount of IgM is up to 10% of all immunoglobulins.

A blood test for immunoglobulin A is indicated for recurrent infectious diseases of the mucous membranes. The normal amount of IgA is 10-15% of the total number of immunoglobulins.

Also, blood for immunoglobulin is donated for various autoimmune diseases. Specific antibodies and their complexes with antigens are determined in pathologies such as systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyroiditis, myasthenia gravis and others.

Human immunoglobulin: application

• immunodeficiency states;
• autoimmune diseases;
• severe viral, bacterial, fungal infections;
• prevention of diseases in persons at risk (for example, in children born very prematurely).

In severe allergic diseases, the doctor may recommend buying anti-allergic immunoglobulin. This drug is an effective remedy for atopic reactions. Indications for use will be:

• allergic dermatitis, neurodermatitis, urticaria, Quincke's edema;
• atopic bronchial asthma;
• pollinosis.

Importance of antibodies in vaccinations

Animal-derived antibodies or human immunoglobulin can be used to manufacture passive immunization preparations.
Immunoglobulin is part of preventive vaccinations against the following diseases:

• mumps (mumps);
• other.

A separate variant of immunoglobulins is toxoid. It is an antibody, the action of which is not directed at the causative agent of the disease, but against the toxic substances produced by it. For example, toxoids are used against tetanus and diphtheria.

There are also products for emergency prophylaxis containing human immunoglobulin. Their price will be an order of magnitude higher, but they are indispensable when it becomes necessary to travel to another country that is an endemic zone of some kind of dangerous infection (for example, yellow fever). Immunity after the introduction of these funds will be less long-term (up to 1 month), but is formed after a day.

However, it should be remembered that the introduction of immunoglobulin is not an alternative to a full-fledged preventive vaccination in accordance with the vaccination schedule, since the emerging immunity is shorter and not so strong.

Immunoglobulin preparations

Human normal immunoglobulin is available in vials containing powder for solution for injection or ready-made solution (Immunoglobulin 25 ml). It contains IgG class antibodies obtained from the plasma of healthy donors, as well as small amounts of IgM and IgA.

Normal human immunoglobulin is contained in the following medicines: Octagam, Pentaglobin, Antirotavirus Immunoglobulin, Antistaphylococcal Immunoglobulin, Normal Human Immunoglobulin, Complex Immunoglobulin Preparation (CIP), Antirhesus Immunoglobulin, Antiallergic Immunoglobulin, Cytotect and many others.

Immunoglobulin injections are prescribed intramuscularly or intravenously only by a qualified doctor. The dose of the drug and the duration of treatment are selected individually, taking into account the age and weight of the patient, as well as the severity of the disease.

Treatment with immunoglobulins

• severe allergic reactions;
• flu-like symptoms (chills

  Where can I buy?

  You can buy the drug at any major pharmacy, or on the Internet. For medicinal products containing immunoglobulin, instructions must be attached. However, it is strictly forbidden to use them without a doctor's prescription, since the drugs have a large number of contraindications. For example, during pregnancy and lactation, immunoglobulin is prohibited.

  The price of immunoglobulin preparations can vary greatly, and depends on the specificity of antibodies, the manufacturer of the drug, the form of release and other characteristics.

  Any medicines containing normal human immunoglobulin must be stored in a refrigerator (at a temperature of +2 - +8 o C).

  Before use, you should consult with a specialist.

Name:

Immunoglobulin (Immunoglobulinum)

Pharmacological
action:

The drug is immunomodulatory and immunostimulating agent. It contains a large number of neutralizing and opsonizing antibodies, thanks to which it effectively resists viruses, bacteria and other pathogens. Also the drug replenishes the number of missing IgG antibodies, thereby reducing the risk of infection in individuals with primary and secondary immunodeficiency. Immunoglobulin effectively replaces and replenishes natural antibodies in the patient's serum.

When administered intravenously the bioavailability of the drug is 100%. Between the extravascular space and human plasma, a gradual redistribution of the active substance of the drug occurs. Equilibrium between these media is achieved on average in 1 week.

Additionally:

The drug must be used only by doctor's prescription. Do not use Immunoglobulin in damaged containers. If the transparency changes in the solution, flakes, suspended particles appear, then such a solution is unsuitable for use. When opening the container, the contents must be used immediately, since the already dissolved drug cannot be stored.

The protective effect of this drug begins to appear 24 hours after administration, its duration is 30 days. In patients with a tendency to migraine or impaired renal function, increased caution should be exercised. You should also be aware that after using Immunoglobulin, there is a passive increase in the amount of antibodies in the blood. In serological testing, this can lead to misinterpretation of the results.

Indications for
application:

The drug is prescribed for replacement therapy, if there is a need to replenish and replace natural antibodies.

Immunoglobulin is used to prevent infections at:
- agammaglobulinemia;
- bone marrow transplantation;
- syndrome of primary and secondary immunodeficiency;
- chronic lymphocytic leukemia;
- variable immunodeficiency associated with agammaglobulinemia;
- AIDS in children.

Also, the drug is used for:
- thrombocytopenic purpura of immune origin;
- severe bacterial infections such as sepsis (in combination with antibiotics);
- viral infections;
- prevention of various infectious diseases in premature infants;
- Guillain-Barré syndrome;
- Kawasaki syndrome (as a rule, in combination with the l / c standard for this disease);
- neutropenia of autoimmune origin;
- chronic demyelinating polyneuropathy;
- hemolytic anemia of autoimmune origin;
- erythrocyte aplasia;
- thrombocytopenia of immune origin;
- hemophilia caused by the synthesis of antibodies to factor P;
- treatment of myasthenia gravis;
- prevention of habitual miscarriage.

Mode of application:

Immunoglobulin injected intravenously drip and intramuscularly. The dosage is prescribed strictly individually, taking into account the type and severity of the disease, the patient's individual tolerance and the state of his immune system.

Side effects:

If, when using the drug, all recommendations for administration, dosage and precautions are observed, then the presence of serious side effects is very rare. Symptoms may appear hours or even days after administration. Almost always, the side effects disappear after you stop taking Immunoglobulin. The main part of the side effects is associated with a high rate of infusion of the drug. By reducing the speed and temporarily suspending reception, you can achieve the disappearance of the bulk of the effects. In other cases, it is necessary to carry out symptomatic therapy.

The manifestation of effects is most likely at the first dose of the drug: during the first hour. It can be a flu-like syndrome - malaise, chills, high body temperature, weakness, headache.

The following symptoms also occur:
- respiratory system(dry cough and shortness of breath);
- digestive system(nausea, diarrhea, vomiting, stomach pain and increased salivation);
cardiovascular system (cyanosis, tachycardia, chest pain, flushing of the face);
- central nervous system(drowsiness, weakness, rarely symptoms of aseptic meningitis - nausea, vomiting, headache, photosensitivity, impaired consciousness, stiff neck);
- kidney(rarely acute tubular necrosis, exacerbation of renal failure in patients with impaired renal function).

Also possible allergic(itching, bronchospasm, skin rash) and local(hyperemia at the site of intramuscular injection) reactions. Other side effects include myalgia, joint pain, back pain, hiccups, and sweating.

In very rare cases collapse, loss of consciousness and severe hypertension were observed. In these severe cases, drug withdrawal is necessary. It is also possible to administer antihistamines, epinephrine and solutions that replace plasma.

Contraindications:

The drug should not be used when:
- hypersensitivity to human immunoglobulins;
- IgA deficiency due to the presence of antibodies to it;
- renal failure;
- exacerbation of the allergic process;
- diabetes mellitus;
- anaphylactic shock on blood products.

The drug should be used with caution with migraine, pregnancy and lactation, decompensated chronic heart failure. Also, if there are diseases in the genesis of which the main immunopathological mechanisms are (nephritis, collagenosis, immune blood diseases), then the drug should be prescribed with caution after the conclusion of a specialist.

Interaction
other medicinal
by other means:

The drug is pharmaceutically incompatible with other drugs. It should not be mixed with other drugs, always use a separate dropper for infusion. With the simultaneous use of Immunoglobulin with active immunization agents for viral diseases such as rubella, chickenpox, measles, mumps, the effectiveness of treatment may decrease. If parenteral use of live virus vaccines is necessary, they can be used after at least 1 month after taking Immunoglobulin. A more desirable waiting period is 3 months. If a large dose of Immunoglobulin is administered, then its effect can last for a year. Also, this drug should not be used in conjunction with calcium gluconate in infants. There are suspicions that this will lead to negative phenomena.