Xanthinol nicotinate instructions for use injections intramuscularly. How xanthinol nicotinate affects the body and why it is recommended for osteochondrosis

A drug that improves microcirculation. Angioprotector

Active substance

Release form, composition and packaging

Solution for intravenous and intramuscular administration colorless, transparent.

Excipients: water for injection (up to 1 ml).

2 ml - ampoules (10) - cardboard boxes.

pharmachologic effect

The drug combines the properties of theophylline and: causes expansion of peripheral vessels, improves collateral circulation, improves oxygenation and tissue nutrition, enhances oxidative phosphorylation and ATP synthesis. Xanthinol nicotinate improves cerebral circulation and reduces the effects of cerebral hypoxia. The drug also activates the processes of fibrinolysis, reduces platelet aggregation.

Indications

- obliterating atherosclerosis;

- endarteritis of the vessels of the lower extremities;

- diabetic angiopathy;

- retinopathy;

- acute thrombophlebitis of superficial and deep veins;

- postthrombophlebitic syndrome;

- trophic ulcers of the lower extremities:

- bedsores;

- Meniere's syndrome;

- dermatoses associated with a vascular trophic disorder;

- cerebrovascular accident.

Contraindications

- glaucoma;

- childhood;

- pregnancy I trimester;

- increased individual sensitivity to the components of the drug.

Dosage

At acute disorders of blood supply to tissues the drug is administered intramuscularly at 0.3 g (2 ml of a 15% solution) 1-3 times / day. Depending on the nature of the disease, the dose can be gradually increased to 0.6-0.9 g (4-6 ml of a 15% solution) 2-3 times / day. The duration of treatment is 2-3 weeks.

At acute disorders of peripheral and cerebral circulation Xanthinol nicotinate is administered intravenously at a rate of 40-50 drops/min. To do this, 1.5 g (10 ml of a 15% solution) of the drug is diluted in 200-500 ml of a 5% glucose solution or in 200 ml of an isotonic solution, the resulting infusion mixture is administered drip for 1.5-4 hours. The infusion can be repeated up to 4 times / day; the duration of treatment is 5-10 days.

Side effects

Xanthinol nicotinate can cause dizziness, a decrease in blood pressure, general weakness, a feeling of heat, tingling and redness of the skin of the upper body, especially the neck and head, nausea, anorexia, diarrhea. These symptoms usually disappear after 10-20 minutes, do not require special treatment and discontinuation of therapy with this drug. If you experience undesirable effects that are not described in this leaflet, and increase the above side effects during therapy with this drug, you should immediately inform your doctor.

With long-term administration in high doses, the drug causes a change in tolerance to, an increase in the activity of hepatic transaminases, alkaline phosphatase, and hyperuricemia.

Overdose

The drug has low toxicity.

Symptoms: acute overdose of xanthinol nicotinate is accompanied by arterial hypotension, general weakness, dizziness, tachycardia, and vomiting.

Treatment: when symptoms of an overdose appear, symptomatic therapy is prescribed.

drug interaction

In order to avoid a sharp decrease in blood pressure, the drug should not be used simultaneously with antihypertensive drugs. It can not be combined with therapy with MAO inhibitors, strophanthin.

special instructions

Xanthinol nicotinate causes a nicotine-like syndrome, accompanied by hyperesthesia of the mucous membrane of the nose and mouth (aggravates the sensitivity of olfactory and taste receptors), and therefore the smell and taste of alcoholic beverages taken during therapy is perceived as sharper and more perverted.

Instructions for use

Xanthinol nicotinate instructions for use

Dosage form

tablets

Compound

Xanthinol nicotinate 150 mg

Pharmacodynamics

Means that improves microcirculation; combines the properties of theophylline and nicotinic acid. It causes expansion of peripheral vessels, improves collateral circulation, improves microcirculation, improves oxygenation and tissue nutrition. It has an antiplatelet effect, activates the processes of fibrinolysis, improves cerebral circulation, reduces blood viscosity.

Enhances oxidative phosphorylation and ATP synthesis. By blocking adenosine receptors and PDE, it increases the content of cAMP in the cell, stimulates the synthesis of NAD and NADP as a substrate.

By reducing OPSS and increasing myocardial contractions, it helps to increase the minute volume of blood and increase cerebral circulation, and reduces the severity of the consequences of cerebral hypoxia.

It causes a nicotine-like syndrome, accompanied by hyperesthesia of the mucous membrane of the nasal cavity and mouth: it exacerbates olfactory and taste sensitivity. In this regard, the smell and taste offered during the nicotine-like reaction of alcoholic beverages and dishes is perceived as sharper and more unpleasant.

With prolonged use, it has an anti-atherosclerotic effect, activates the processes of fibrinolysis, reduces the concentration of cholesterol and atherogenic lipids, increases the activity of lipoprotein lipase, reduces blood viscosity, and reduces platelet aggregation.

Side effects

From the side of the cardiovascular system: a decrease in blood pressure, a transient feeling of warmth, redness of the skin is possible.

From the digestive system: rarely - nausea, diarrhea, anorexia, gastralgia; with prolonged use in high doses, an increase in the level of transaminases and alkaline phosphatase is possible.

Other: weakness, dizziness; with prolonged use in high doses, a change in glucose tolerance, an increase in the level of uric acid in the blood serum is possible.

Selling Features

prescription

Special conditions

Use with caution in labile blood pressure.

Use with caution simultaneously with antihypertensive drugs.

Influence on the ability to drive vehicles and control mechanisms

Use with extreme caution in drivers of vehicles, as well as in patients involved in potentially hazardous activities.

Indications

Raynaud's disease, obliterating endarteritis, obliterating atherosclerosis of the vessels of the extremities, thromboangiitis obliterans (Buerger's disease), diabetic angiopathy, vascular thrombosis and embolism, post-thrombophlebitic syndrome, trophic ulcers of the legs, difficult-to-heal wounds, bedsores, cerebrovascular accidents, Meniere's syndrome, atherosclerosis of the coronary vessels, atherosclerosis cerebral vessels, hypercholesterolemia, hypertriglyceridemia, intrauterine and postpartum fetal asphyxia, dermatoses due to impaired trophism of vascular origin, scleroderma, Buschke's scleredema.

Contraindications

Acute bleeding, acute myocardial infarction, mitral stenosis, acute heart failure, chronic heart failure in the stage of decompensation, arterial hypotension, peptic ulcer of the stomach and duodenum in the acute phase, acute renal failure, glaucoma, pregnancy, hypersensitivity to xanthinol nicotinate.

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

drug interaction

With simultaneous use with drugs that have a hypotensive effect (beta-blockers, ergot alkaloids, alpha-blockers, sympatholytics, ganglion blockers), with strophanthin, a sharp increase in their action is possible.

Prices for Xanthinol nicotinate in other cities

Antispasmodics are purine derivatives.

Composition of Xanthinol Nicotinate

The active substance is Xanthinol nicotinate.

Manufacturers

Dalchimpharm (Russia), Moskhimfarmpreparaty im. ON THE. Semashko (Russia), Novosibkhimfarm (Russia)

pharmachologic effect

It has a vasodilating, antiaggregatory, anti-atherosclerotic effect.

Blocks adenosine receptors and phosphodiesterase, increasing the level of cAMP in the cell, substrate stimulates the synthesis of nicotine adenine dinucleotide (NAD) and NAD-phosphate (nicotinic acid).

It has a vasodilating effect, reduces the total peripheral vascular resistance, inhibits platelet aggregation, improves microcirculation, oxygenation and tissue nutrition, increases cerebral circulation, reduces blood viscosity, activates fibrinolysis; with prolonged use, it can delay the development of atherosclerosis, lower cholesterol and atherogenic lipids, and enhance the activity of lipoprotein lipase.

Side effects of xanthinol nicotinate

Arterial hypotension, transient feeling of warmth, redness of the skin, weakness, dizziness, nausea, diarrhea, anorexia, gastralgia.

With long-term administration of high doses - a decrease in glucose tolerance, an increase in the activity of hepatic transaminases and alkaline phosphatase, hyperuricemia.

Indications for use

Cerebrovascular insufficiency, atherosclerosis of cerebral vessels, cerebrovascular accidents, obliterating atherosclerosis of vessels of the lower extremities, Raynaud's disease, Buerger's disease, obliterating endarteritis, acute arterial thrombosis, diabetic angiopathy, retinopathy, acute thrombophlebitis (superficial and deep veins), postthrombophlebitis syndrome, trophic ulcers of the lower extremities, bedsores, migraine, Meniere's syndrome, dermatoses (due to violation of the trophism of vascular origin), atherosclerosis of the coronary vessels, hypercholesterolemia, hypertriglyceridemia, intrauterine and postpartum fetal asphyxia.

Xanthinol nicotinate contraindications

Hypersensitivity, severe congestive heart failure, acute bleeding, acute myocardial infarction, peptic ulcer of the stomach and duodenum in the acute stage.

Application restrictions:

• arterial hypotension,
• pregnancy (especially in the 1st trimester).

Method of application and dosage

In / m enter 2-6 ml of a 15% solution for 2-3 weeks.

In / in the stream - 2 ml of a 15% solution 1-2 times a day for 5-10 days (the patient should be in a horizontal position).

In/in drip administered at a rate of 40-50 drops/min, diluting 10 ml of 15% solution in 200-500 ml of 5% glucose solution or 200 ml of isotonic sodium chloride solution.

Overdose

No data.

Interaction

Enhances (mutually) the effect of antihypertensive drugs (beta-blockers, ergot alkaloids, alpha-blockers, sympatholytics, ganglion blockers).

special instructions

Caution should be exercised when administered simultaneously with antihypertensive agents and strophanthin.

It is mainly used to dilate blood vessels. Also, its active substances help improve blood circulation in the brain. After taking this medicine, the patient's heart rate increases significantly, and the metabolic process in the brain tissues improves. Before using the drug, you must carefully read the instructions for use, study the properties , side effects and contraindications for use.

Pharmacological group of the substance Xanthinol nicotinate:

• antiplatelet agents;
• vasodilators;
• angioprotectors and microcirculation correctors;
• nicotinates;
• correctors of disorders of cerebral circulation.

Pharmacokinetics

Due to the fact that this drug is available in the form of a solution, it is characterized by the speed of action. After an injection of Xanthinol, nicotinate is absorbed into the digestive tract in a short period of time and is distributed in equal proportions to all organs and tissues. The process of theophylline metabolism is carried out directly in the liver, with the help of urine 5-20% of methylxanthine derivatives are excreted.

Xanthinol nicotinate is separated in the body, forming xanthinol and nicotinic acid. In smokers and people with chronic alcoholism, the half-life of T1 / 2 is significantly shortened. A similar process occurs if a person takes carbamazepine, barbiturate, rifampicin. In the process of taking cimetidine, ciprofloxacin, erythromycin and oral contraceptives, as well as with cirrhosis of the liver and heart failure, the half-life of T1 / 2 increases. These changes are of great clinical importance, since theophylline is characterized by a small breadth of therapeutic effects. It has a bronchodilatory effect in the event that the concentration of blood plasma is 10-20 mg / l. But at such a concentration, there is a high probability of side effects that increase in complete dependence on the values ​​​​of blood plasma.

Indications for use

Xanthinol nicotinate should be used only on the advice of a doctor.

The drug is prescribed for use if the patient has the following conditions:

• symptoms of thrombophlebitis;
• atherosclerosis of the lower extremities ;
• the period after surgery on the brain;
• headaches, migraines;
• vascular atherosclerosis;
• Raynaud's disease;
• the presence of thrombosis of varying severity;
• retinopathy therapy;
• violations of the processes of cerebral circulation;
• Meniere's disease;
• signs of diabetic angiopathy;
• the formation of ulcers on the legs;
• the process of detachment of the retina of the eyeball;
• vascular disease of the eye.

It must be remembered that self-medication is strictly prohibited. Each disease requires a specific treatment prescribed by a qualified specialist. The doctor will determine the required dosage of the drug and the duration of the course of treatment, in accordance with the characteristics of the course of the disease and the instructions for using Xanthinol nicotinate .

Contraindications

Like any other drug, a drug called Xanthinol nicotinate has contraindications for use. There are cases when its use can adversely affect the health of the patient. There are several situations when you should refrain from injecting the drug:

• allergy to the components that are contained in the preparation;
• the presence of symptoms of glaucoma;
• heart disease - myocarditis;
• the period after a heart attack;
• the presence of ulcerative formations in the stomach;
• unstable work of the kidneys and liver;
• congestive heart failure;
• heavy bleeding;
• mitral stenosis.

If the patient has at least one of the above symptoms, then the use of Xanthinol nicotinate in his case is strictly prohibited. To avoid complications, it is necessary to conduct an examination of the body before treatment.

How to use the drug correctly?

Adhering to the instructions for use of Xanthinol nicotinate , medical specialists prescribe injections to patients , administered intravenously or intramuscularly. The solution can be administered only under the supervision of the attending physician. Xanthinol nicotinate is prescribed for people suffering from severe circulatory disorders. In this case, 2 ml of the drug is prescribed for therapy twice a day intravenously. After some time, the doctor may prescribe the administration of the drug intramuscularly. Patients are injected with 2 ml of solution 3 times a day. Also, in order to speed up recovery, the doctor can prescribe Xanthinol nicotinate in the form of tablets - such a complex treatment will achieve the best result. For therapy, 2 tablets are prescribed three times a day.

In cases where the disease is already advanced and is in a severe stage, the patient is prescribed Xanthinol nicotinate injections by intravenous drip method. With this method of drug administration, the dosage will be 10 ml. A dropper is usually placed for 3-4 hours. In the presence of severe complications, the drug is administered 4 times a day. The duration of the course of treatment with this medicine is determined by the attending physician. Most often, the course does not exceed 21 days.

People suffering from impaired blood supply to the tissues are prescribed 2 ml of the drug three times a day. A feature of this therapy is that the dosage is gradually increased to a maximum value of 6 ml. It is important that the patient at the time of treatment was under the supervision of the attending physician. The duration of such treatment is about 3 weeks.

Also, Xanthinol nicotinate is actively used in ophthalmology. The drug is used in complex therapy by iontophoresis. The most optimal dosage is 300 mg of the drug per day. The duration of the first procedure should not exceed 15 minutes. After each procedure, the time increases. By the end of the course, it can reach up to half an hour. The full course of treatment should not exceed 20 days.

drug overdose

In medical practice, cases may occur when the patient has been given too much of the drug. An overdose is expressed by the following symptoms:

• gagging;
• a strong and sudden attack of tachycardia;
• the appearance of redness on the skin and tingling sensations;
• severe fatigue and lethargy;
• diarrhea;
• fainting state.

In cases where the injection of Xanthinol nicotinate was administered too quickly, complications may occur. Incorrect injection has the following consequences:

• feelings of suffocation;
• severe heart pain;
• dizziness;
• signs of arterial hypotension.

If the patient has these signs, you should immediately contact a medical institution. Doctors will establish the cause of their occurrence and will carry out symptomatic therapy until the negative consequences of an overdose completely disappear.

Adverse reactions to the drug

When using Xanthinol nicotinate in a patient, an adverse reaction to the components in the composition of the drug may occur. It can also appear if the instructions for its use are not followed.

If the patient has signs of the above side effects, you should immediately consult a doctor. The specialist can both change the dosage and prohibit the use of the drug. Ignoring the side effects entails serious complications and disturbances in the body.

Medicine analogs

In cases where the body reacts negatively to any component in the composition of the drug, Xanthinol nicotinate analogs may be prescribed to the patient. The selection of such drugs is carried out only by the attending physician. Currently, the following analogues of this drug are known:

• Latren.
• Pentilin.
• Agapurin.
• Pentotren.
• Pentoxifylline.
• Vasonite.

Trade names

Country of origin

Product group

Means that improves microcirculation; combines the properties of theophylline and nicotinic acid.

Release form

• 10 - cellular contour packs (3) - packs of cardboard. 10 - cellular contour packs (6) - packs of cardboard. 10 ampoules of 2 ml in a pack of 10 pcs. - cellular contour packings (6) - packs of cardboard. 2 ml - ampoules (10) - cardboard boxes. 2 ml - ampoules (10) - packs of cardboard. 2 ml - ampoules (5) - blister packs (2) - cardboard packs. 2 ml - ampoules (5) - blister packs (2) - cardboard packs. 2 ml - ampoules (10) - cardboard boxes.

Description of the dosage form

• clear colorless solution Solution for intravenous and intramuscular injection Solution for intravenous and intramuscular injection colorless transparent. Solution for intravenous and intramuscular injection Solution for intramuscular injection transparent, colorless Solution for injection 15% colorless, transparent. tablets

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• 1 ml 1 amp. xanthinol nicotinate 150 mg 300 mg Excipients: water for injection. 1 tab. xanthinol nicotinate 150 mg 1 amp. xanthinol nicotinate 300 mg 1 ml xanthinol nicotinate 150 mg Excipients: water for injection. 1 ml of the drug contains: active substance: xanthinol nicotinate - 150.0 mg; excipient: water for injection - up to 1.0 ml. 1 tab. xanthinol nicotinate 150 mg Xanthinol nicotinate 15 mg/ml; Auxiliary in-va: water d / in

Xanthinol nicotinate indications for use

• Raynaud's disease, obliterating endarteritis, obliterating atherosclerosis of the vessels of the extremities, thromboangiitis obliterans (Buerger's disease), diabetic angiopathy, vascular thrombosis and embolism, post-thrombophlebitic syndrome, trophic ulcers of the legs, difficult-to-heal wounds, bedsores, cerebrovascular accidents, Meniere's syndrome, atherosclerosis of the coronary vessels, atherosclerosis cerebral vessels, hypercholesterolemia, hypertriglyceridemia, intrauterine and postpartum fetal asphyxia, dermatoses due to impaired trophism of vascular origin, scleroderma, Buschke's scleredema.

Xanthinol nicotinate contraindications

• Acute bleeding, acute myocardial infarction, mitral stenosis, acute heart failure, chronic heart failure in the stage of decompensation, arterial hypotension, peptic ulcer of the stomach and duodenum in the acute phase, acute renal failure, glaucoma, pregnancy, hypersensitivity to xanthinol nicotinate. Application during pregnancy and lactation Contraindicated in pregnancy and lactation.

xanthinol nicotinate dosage

• 150 mg 150 mg/ml 300 mg/2 ml

xanthinol nicotinate side effects

• From the side of the cardiovascular system: a decrease in blood pressure, dizziness, a feeling of heat, redness of the skin is possible. From the digestive system: nausea, diarrhea, anorexia, gastralgia, abdominal pain, epigastric pain. From the nervous system: headache. Allergic reactions: pruritus, urticaria, angioedema, anaphylactic shock. Other: weakness, chills, tingling of the skin, especially in the head and neck. These symptoms usually disappear after 10-20 minutes, do not require special treatment and stop using this drug. When using nicotinic acid preparations, a false increase in the concentration of catecholamines in the blood plasma and urine may be noted, and a false positive result of determining glucose in the urine using the Benedict test may also be noted. With long-term administration in high doses, the drug causes a change in glucose tolerance, an increase in the activity of "liver" transaminases (ACT, ALT) in the blood serum, an increase in the activity of alkaline phosphatase in the blood serum, an increase in the content of uric acid in the blood serum. If you experience undesirable effects that are not described in this leaflet, and increase the above side effects during therapy with this drug, you should immediately inform your doctor.

drug interaction

Overdose

Storage conditions

• keep away from children
• store in a place protected from light