Whether to treat a mild titer of mycoplasma pneumoniae. Mycoplasma pneumoniae, IgG antibodies, quantitative, blood

It is an infectious disease of the respiratory system caused by pathogenic microorganisms. Determining the type of pathogen is of great importance in the diagnosis and treatment of the disease, since each of them is sensitive to a certain category of drugs. Most often, the pathological process is caused by pneumococci and staphylococci, but there are other types of bacteria, in particular, mycoplasma pneumoniae. What is pneumonia caused by this pathogen, and how is it treated?

Mycoplasma is a bacterium that can cause urinary and respiratory infections. The list of varieties of this microorganism includes Mycoplasma pneumonia (Mycoplasma pneumoniae), which causes, or respiratory mycoplasmosis.

Usually the bacterium is transmitted as an airborne droplet, the endogenous route of infection is also found. Mycoplasma is present in the body of every person, and under favorable conditions (immunodeficiency states, pathologies of the respiratory system, tumor processes in the blood) begins to multiply actively. This type of disease is diagnosed in 20% of people with pneumonia, and most often it affects children under 5 and young adults, and in patients older than 35 is observed quite rarely.

The incubation period for mycoplasma pneumonia ranges from 1 to 3 weeks, symptoms resemble flu or pharyngitis, and include:

temperature rise to 37-37.5 degrees;
sore throat, dry cough;
nasal congestion;
headache, muscle and joint pain;
skin rash;
enlarged lymph nodes;
deterioration in general well-being.

As a rule, the symptoms increase gradually, but there is an acute onset of the disease with manifestations of intoxication of the body. A characteristic symptom of mycoplasma pneumonia is a dry, debilitating cough with a small amount of viscous sputum. It lasts at least 10-15 days after infection of the body, and sometimes can last up to 4-6 weeks, since mycoplasma causes airway obstruction.

IMPORTANT! Mycoplasma pneumonia belongs to the category of atypical forms of the disease, and usually proceeds in a severe form - due to the special structure of the bacterium, which resembles the structure of the cells of the human body, antibodies to it begin to be produced quite late.

How to identify a disease

Diagnosis of mycoplasmal pneumonia requires special attention, as the signs of the disease resemble those of other respiratory infections. To identify the pathogen and make an accurate diagnosis, a number of instrumental and clinical studies are required.

External examination and listening of the chest. The classic manifestations of pneumonia (high fever, cough) in the mycoplasmal form of the disease are not too pronounced, but extrapulmonary symptoms are present - skin rash, muscle and joint pain, sometimes pain in the ears and eyes. When listening to the chest, rare medium or small bubbling sounds are heard, which indicates the presence of fluid in the lungs and bronchi.
, MRI, CT. On the X-ray, there is a noticeable increase in the pattern of the lungs with foci of infiltrates typical of the disease, which, as a rule, are located in the lower part of the lungs. Sometimes, to clarify the diagnosis and identify comorbidities, computed or magnetic resonance imaging is required.
General blood analysis. A clinical blood test determines moderate leukocytosis and a slight rise in ESR (with mycoplasmal pneumonia, the signs of a pathological process in the general blood test are less pronounced than with inflammation of the lungs of bacterial origin).
PCR. Polymerase chain reaction, or PCR method, is one of the most informative ways to detect mycoplasma pneumonia in the body. It allows you to find fragments of pathogenic microorganisms in the test material (a sample of the patient's venous blood), distinguish them from others and multiply, which allows you to accurately determine the causative agent of the pathological process.

REFERENCE! Other methods that are used to detect other forms of pneumonia (for example, sputum examination) are not used for mycoplasmal pneumonia, as they have no diagnostic value.

Antibodies IgA, IgM and IgG if detected

After mycoplasma pneumoniae enters the respiratory tract, the body begins to produce specific immunoglobulins, which can be detected by ELISA (enzymatic immunoassay).

This is the most informative diagnostic method that allows you to determine not only the presence of the disease, but also the features of its clinical picture - acute, chronic form or re-infection.

There are three types of antibodies that, if positive, can determine the presence of an infection - IgA, IgM and IgG, what does this mean?

Immediately after infection, the production of IgM immunoglobulins begins, and after 5-7 days - IgG antibodies, and their level remains elevated longer than the IgM titer, and significantly decreases upon recovery. The production of IgA proteins begins last, after the appearance of IgG, and continues for a year or more.

To make an accurate diagnosis, immunoglobulins IgM and IgG are detected, it is recommended to take an analysis 1-4 weeks after the onset of the disease at least twice (a single measurement of the level of antibodies does not give a reliable result). The presence of the disease is evidenced by a dynamic increase in the level of IgM antibodies, as well as an increase in the concentration of IgG proteins in samples taken sequentially from intervals of more than 2 weeks. An elevated titer of IgA immunoglobulins indicates an acute or chronic course of mycoplasmal pneumonia, as well as re-infection.

IMPORTANT! Diagnosis of the pathological process caused by Mycoplasma pneumonia must necessarily be comprehensive, and include the collection of anamnesis, analysis of symptoms and complaints, as well as the determination of IgM and IgG antibodies.

Healing methods

Mycoplasma pneumonia can lead to serious complications, so treatment should be started as soon as a diagnosis is made. The basis of treatment in adults and children is, as a rule, from the group of macrolides, but in the presence of contraindications and allergic reactions, drugs of other groups may be prescribed, and the course lasts at least 2 weeks.

Together with antimicrobial agents, doctors prescribe antipyretics, painkillers, and antihistamines. In addition, patients need bed rest, a diet high in vitamins and minerals, and plenty of fluids.

During the recovery period, special attention should be paid to rehabilitation activities - massage, therapeutic exercises, outdoor walks, spa treatment. This is especially true for children, the elderly and patients who have suffered a severe form of pneumonia, accompanied by a deterioration in respiratory function.

Anti-Mycoplasma pneumoniae-IgG, quantitative analysis.

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Study Description

Preparation for the study: Special training is not required. It is recommended not to smoke 30 minutes before donating blood for research. Material under study: Taking blood

The production of IgG to Mycoplasma pneumoniae begins approximately 2-4 weeks after infection, and continues for a long time: up to a year or more.

The presence in the blood of class G immunoglobulins to Mycoplasma pneumoniae indicates the presence of an acute or past illness, as well as reinfection and a chronic inflammatory process.

It should be remembered that the diagnosis of Mycoplasma pneumoniae infection should be complex, based on epidemiological history, clinical symptoms and data from other tests. A study for the presence of class M and G immunoglobulins is mandatory.

Method

Enzyme immunoassay (ELISA) is a laboratory immunological method for the qualitative or quantitative determination of various compounds, macromolecules, viruses, etc., which is based on a specific antigen-antibody reaction. The resulting complex is detected using the enzyme as a label for signal recording. Due to the undoubted advantages - ease of use, speed, objective automated recording of results, the possibility of studying immunoglobulins of various classes (which plays a role in the early diagnosis of diseases, their prognosis), ELISA is currently one of the main methods of laboratory diagnostics.

Reference values - norm
(Mycoplasma pneumoniae, IgG antibodies, quantitative, blood)

Information regarding the reference values of the indicators, as well as the very composition of the indicators included in the analysis, may differ slightly depending on the laboratory!

Norm:

Normally, it is not detected (negative), if the desired antibodies are found, their number is indicated in the conclusion.

Indications

Symptoms of infection with mycoplasma (unproductive cough, fever, headaches, sore throat and muscles that persist for several weeks) - to confirm infection (including reinfection) with Mycoplasma pneumoniae, as well as for the differential diagnosis of mycoplasma pneumonia from other infectious diseases of the respiratory tract ..
Suspicion of a chronic or persistent form of mycoplasmal pneumonia, manifested by frequent relapses.

Increasing values (positive result)

Current acute mycoplasma infection
Chronic mycoplasma infection
The presence of IgG in the absence of IgM indicates reinfection with Mycoplasma pneumoniae.

To date, there are no clinical, epidemiological or laboratory symptoms that would allow early detection of Mycoplasma pneumoniae lung involvement. Diagnosis is carried out only after the appearance of symptoms characteristic of the pathology. There are certain signs that make it possible to suspect SARS:

A sharp increase in body temperature from the first for the disease from 38 ° C.
Productive cough with viscous purulent sputum.
Difficulty breathing, shortness of breath and blue nasolabial triangle.
An increase in the number of leukocytes in the blood.

PCR

An experimental diagnostic method of molecular biology for determining the state of DNA fragments in a biological material is a polymerase chain reaction. PCR for suspected mycoplasma pneumonia is a study of blood, sputum, pleural fluid and other types of biomaterial for pathogenic microorganisms.

Advantages of PCR:

Increased percentage of detection of DNA pathogens in clinical samples in comparison with standard diagnostic microbiological methods.
High sensitivity for suspected generalized processes in the body.
Identification of difficult-to-cultivate microorganisms and non-culturable forms of bacteria in persistent infections.

Detection of pathogens in the biomaterial is not always of diagnostic value. This is due to the fact that many microorganisms normally live in the respiratory tract, but under certain conditions they realize their pathogenic potential, causing infectious processes.

ELISA

A laboratory immunological method for the qualitative/quantitative determination of viruses and other pathogens is ELISA. ELISA is performed in such cases:

Search for specific antibodies to infectious pathologies.
Determination of antigens for various diseases.
Study of hormonal status.
Examination for autoimmune diseases and tumor markers.

The advantages of ELISA are high sensitivity and specificity, the ability to determine the disease and follow the dynamics of the pathological process. The main disadvantage of the method is the detection of antibodies, that is, the immune response, and not the pathogen itself.

To detect Mycoplasma pneumoniae, blood is taken for ELISA. The analysis is considered confirmed if IgM, G immunoglobulins are detected in the blood. If the increase in antibody titer is increased by 3-4 or more times, then the enzyme immunoassay confirms atypical pneumonia.

Antibodies to mycoplasma pneumoniae igG

Specific antibodies produced by the immune system in response to infection by various pathogens are immunoglobulins. Antibodies to Mycoplasma pneumonia igg are serological markers indicating a pathological process in the body.

Mycoplasma pneumoniae occupies an intermediate position between bacteria, protozoa and viruses. It causes damage to the respiratory system and accounts for about 20% of all cases of community-acquired pneumonia. After infection, the immune system begins to actively produce immunoglobulins of class A, M and G.

IgG against mycoplasma infection appears after 2-4 weeks and continues to be produced for a long period of time, usually more than a year. A blood test for these immunoglobulins is included in the complex of mandatory laboratory tests for suspected atypical pneumonia. To reduce the risk of diagnostic errors, a simultaneous analysis for IgM and IgG is indicated.

Antibodies to mycoplasma pneumoniae igM

To confirm acute mycoplasmal lesions of the respiratory system, patients are prescribed enzyme immunoassay. Antibodies to mycoplasma pneumoniae IgM make it possible to differentiate atypical inflammation from other pathologies of the respiratory tract, for example, an infectious process caused by streptococci or staphylococci.

The reason for conducting a laboratory study are the following symptoms:

Unproductive cough for a long period of time.
Severe pain in the throat and chest.
Muscle pain.
Deterioration of general well-being.

The coefficient of positivity, indicating infection, are the values: 0-0.84. A negative result is possible not only in the absence of the disease, but also in chronic mycoplasmal infection, an early stage of infection, when the body has not yet developed an immune response. It should also be taken into account that IgM is usually not released during re-initiation.

Cold antibodies in mycoplasma pneumonia

Antibodies that cause erythrocyte aggregation when exposed to low temperatures are cold antibodies. In Mycoplasma pneumoniae, they most often belong to the IgM class. Normally, they can be found in healthy people, but they increase significantly 7-10 days after the onset of the disease. Cold exposure causes acute transient hemolytic anemia. A persistent increase in the titer of agglutinins leads to the development of a chronic form of pathology.

There are several types of cold agglutinins:

The disease is caused by primary intravascular hemodialysis with monoclonal antibodies to erythrocyte I antigen. In this case, cold antibodies are formed in lymphoproliferative disorders.
The disease state is due to secondary intravascular hemolysis. It is characterized by polyclonal antibodies in low titer and active in a narrow temperature range. Manifested with various infections. For example, with mycoplasmal pneumonia, cold agglutinins to the I-antigen of erythrocytes occur.

Cold antibodies in SARS can be a mixture of various immunoglobulins. The activation of agglutinins begins already at 37 °C and causes such pathological reactions: acrocyanosis and hemolysis due to complement activation.

Instrumental diagnostics

To determine the localization of the inflammatory focus in the lungs, its size and other features, instrumental diagnostics is shown. The complex of studies consists of the following procedures:

Radiography.
Fibrobronchoscopy.
The function of external respiration.
Electrocardiography.

The main diagnostic method is radiography. It allows you to identify foci of inflammation, which in the picture appear darker than the rest of the lung. There is also a change in the lung pattern and proliferation of connective tissue. With pneumonia, it is possible to change the pulmonary roots, damage the pleura, and even the presence of an abscess in the organ. Radiography is performed in two projections - direct and lateral.

Tomography gives the same result as an x-ray, so it is rarely performed if SARS is suspected. Ultrasound diagnostics is also rarely performed, since it detects only exudate in the lungs, which is also visible on x-rays. As for bronchoscopy, it is necessary to obtain more accurate results of the study.

Differential Diagnosis

For successful treatment of any disease, a comprehensive examination is necessary. Differential diagnosis of atypical pneumonia is aimed at excluding pathologies with similar symptoms. This allows you to establish an accurate diagnosis and prescribe therapy.

Differentiation is carried out in several stages:

Collection of primary data and formation of a list of possible diseases.
The study of symptoms, changes in the dynamics of well-being and other factors of the disease.
Comparative analysis of the obtained data, assessment of similar and different values.
Identification of third-party symptoms that are not related to the suspected pathology.
Exclusion of diseases whose clinical signs are not included in the overall picture.
Making a final diagnosis and drawing up a treatment plan.

The data collected and analyzed during the diagnostic process give a reliable picture of the disease state. Differentiation of SARS is carried out with the most common harmful microorganisms:

Mycoplasma - acute onset, catarrh of the upper respiratory tract, cough with poorly separated sputum. As a rule, it develops in young patients.
Pneumococci - acute onset of the disease, severe fever, severe course, but a good response to penicillin antibiotics.
Staphylococci - acute onset and severe course, limited infiltrates, resistance to penicillins.
Haemophilus influenzae - severe course, extensive infiltrates, thick sputum with blood impurities, abscess formation. Most often occurs in patients with chronic bronchopulmonary pathologies and alcoholism.
Legionellosis - severe course, diarrhea and liver dysfunction, neurological disorders. People who stay in air-conditioned rooms for a long time are susceptible to the disease.
Aspiration - putrid sputum, multiple and confluent foci of inflammation, reflex cough and increased salivation.
Pneumocysts - increasing shortness of breath with frequent coughing attacks. Severe symptoms with mild radiographic features.
Fungi - the rapid development of a febrile state, cough with poor sputum discharge, severe febrile state, chest pain.

Most pathogens have a similar symptom complex, so considerable attention is paid to bacterial culture. Atypical pneumonia is differentiated from other diseases. During the examination, the doctor determines extrapulmonary pathologies with signs of the respiratory system and limits pulmonary inflammation from other possible disorders of the respiratory system:

Tuberculosis is most often mistaken for pneumonia. It proceeds with a dry cough, subfebrile body temperature and pallor of the skin. If positive tuberculin tests are detected, then the diagnosis becomes more complicated. The main differences from pneumonia: heterogeneous and compacted shadows, areas of enlightenment are similar to seeded foci. In sputum, a massive spread of mycobacteria is observed. Leukocytes are increased in the blood.
Bronchitis - occurs after SARS or against their background. In the early stages, it is accompanied by a dry cough, which gradually turns into a productive one. The elevated temperature lasts for 2-3 days, and then remains in subfebrile limits. There is no infiltration, the pulmonary pattern is enhanced. Very often, pneumonia is diagnosed as an exacerbation of bronchitis.
Influenza - in the epidemiological period it is very difficult to distinguish between pulmonary inflammation and influenza infection. The features of the clinical picture of the disease are taken into account.
Pleurisy is an inflammatory pathology in the respiratory system, similar to pleural changes. Occurs with pain in the chest and during coughing. The main diagnostic sign of pleurisy is wheezing, that is, the sounds of friction of the pleura during breathing. Particular attention is paid to the results of biochemical analysis.
Atelectasis is a pulmonary pathology with tissue collapse and impaired gas exchange. In its symptoms, it resembles pneumonia: respiratory failure, shortness of breath, cyanosis of the skin. Chest pain in this disease is caused by a violation of gas exchange. In the curtailed area of the organ, an infection gradually develops. Atelectasis is associated with trauma, blockage and compression of the lungs, and destructive tissue changes.
Oncological processes - the initial stages of the disease do not differ from atypical pneumonia. Differentiation is based on a comprehensive diagnostic approach with a careful study of the signs of cancer.

Answers:

Good afternoon, Maria. Because IgG antibodies to chlamydia pneumonia were not detected by ELISA, then you have not met with it before. The detection of IgG antibodies to mycoplasma indicates that you have previously met with it. To know whether you have it now, whether it causes problems requiring treatment, you need to be examined and visit a doctor in person. Be healthy!

2011-01-18 16:32:16

Irina asks:

Hello, please tell me. I passed the tests and I have mycoplasma pneumonia IgG-3.02 IgM-1.63 The doctor said that this infection is transmitted only sexually and my husband and I need to be treated. And I read that this infection is also transmitted by airborne droplets. And if does my mother live with us, does she also need to be treated? And I also have Escherichia coli Staphilococcus aureus Enterococcus faecalis 5th day in the morning. Fluzak 2nd day and 5th day. And I need terzhinan suppositories. Tell me if the treatment is correct.

Responsible Sergienko Alena Nikolaevna:

Hello, it is necessary to do a sowing on the sensitivity of mycoplasma to antibiotics and then it will be treated. At the expense of infection, the truth is on your side.

2011-01-17 19:25:31

Irina asks:

2014-02-06 17:14:50

Asks Olga, 24 years old:

Hello. Concerned about frequent colds (about 5 per year), periodically sore throat with reddening of the back wall. The diagnosis is chronic tonsillitis. There is no angina, there is no high temperature, the plugs are not visible, everything is clean on the third wash, the tonsils are not large. The temperature is 36.9-37.2 for about a year. Rise during the day, mostly in the afternoon, very rarely in the morning.
Examined
1. Complete blood count, for about two years, ESR increased from 20 to 35, at a rate of no more than 15. Sometimes leukocytes are slightly increased (10 at a rate of up to 9)
2. Biochemistry is normal.
Rheumatoid factor normal
C-reactive protein normal
ASLO up to 500 at a rate of 0.01-200
There was a decrease to 200 with complex treatment (washing the tonsils, rinsing, antibiotics, bacteriophages), then again increasing.
3. Blood for sterility norm
4. Antibodies to antigens of opisthorchis, echinococcus, toxocara, trichinella IgG negative
5. Antibodies to cytomegalovirus IgG positive (93.8)
(values less than 0.5 negative
greater than 1.0 positive)
6. Antibodies to cytomegalovirus IgM negative
7. Antibodies to the nuclear antigen of the Epstein-Barr virus IgG positive (32.10) (indicators less than 5 negative; more than 20 positive); Antibodies to the capsid protein of the Epstein-barr virus IgM were negative.
8. PCR diagnostics
DNA of candida albicans, chlamydia pneumonia, streptococcus pneumonia, mycoplasma pneumonia, streptococcus pyogenes was not found in the scraping.
9. Throat swab, found staphylococcus aures 1*10 grade 5
10. Antibodies to toxoplasmosis IgG and IgM negative
11. hormones Tz, T4 free, TSH sensitive norm
12. Immunoglobulins G, M, E norm
13. Urinalysis general and according to Nechiporenko norm
14. Analysis of Cala norm
15. Ultrasound of the abdominal cavity, kidneys, thyroid gland, lymph nodes, mammary glands are normal
16. ECHO of the heart is normal, ECG is a moderate change in the myocardium
17. CT chest without pathology
18. Consultations of a gynecologist, cardiologist, dentist, infectious disease specialist, rheumatologist, endocrinologist, everything is normal.
TELL! QUESTION
*Is there a test to determine the function of the tonsils?
* One doctor suggests the removal of the tonsils, based on the indications of ASLO, others advise to wait, treat.
* Prolonged temperature is typical for tonsillitis? * Could it be related to lowered immunity?
WHAT OTHER Examinations would you recommend?

Responsible Vasquez Estuardo Eduardovich:

Hello Olga.
The analyzes and the condition you describe indicate a chronic inflammatory process with the onset of a weakening of the immune system.
Answering your questions:
Is there a test to determine the function of the tonsils? - there are no specific ones, and we do not see the expediency.
Different doctors - different opinions and methods of struggle, there are no problems in this. We would agree with the second opinion.
Prolonged temperature is characteristic of tonsillitis? - answer incl. regarding immunity, we have already written to you above.
Now we do not consider any examinations necessary, and also do not insist on your doctor. Examinations will be needed only periodically and at the direction and initiative of the attending physician.

2013-03-01 18:52:53

Daria Statinova asks:

Responsible Shapoval Olga Sergeevna:

Hello Daria. Considering the existing complaints of discharge and burning, pain syndrome and menstrual irregularities, most likely there is still an untreated ureaplasma infection, which was identified back in 2009. There is such a tactic when ureaplasma is really defined as a conditionally normal component of the microflora of the genital tract (in 20% of women, its healthy carriage is determined). In this case, treatment is not prescribed. However, if a woman has any complaints from the urogenital area, a chronic inflammatory process, infertility, pregnancy with complications, cervical erosion, treatment is definitely required. Although ureaplasma was not found in your analyzes, this is not a reason to calm down. Did you pass the test correctly (do not use any antibiotics, vaginal suppositories for 2-3 days, it is better to take it on the 2-3rd day after the end of menstruation by PCR from the cervical canal and urethra, 2 hours before the smear is not urinated). I recommend repeating ureaplasma PCR in another laboratory. But the identified EBV can indeed be the cause of the development of chronic fatigue syndrome, which is clearly present in you. I recommend adding vitamin therapy (vitamins of group B, vitamin C), adaptogens (for example, echinacea) to the complex of treatment. This syndrome often develops in a group of people whose lives are subject to constant stress (think about how to reduce this factor), whose work is associated with computer radiation, who have insufficient physical activity (a wide range of sports and relaxation techniques), and who are negatively disposed towards further life perspectives (create positive motivations on your own or with the help of various psychotherapeutic techniques). Optimize your sleep and rest regimen, balance your diet, choose an adequate and interesting physical load, and the treatment process will be more intense. Physiotherapeutic methods also work well: wellness massage, oxygen baths and cocktails, exercise therapy. As you can see, the range is quite wide and the best option is to think about undergoing spa treatment and then normalizing your daily schedule.

2012-01-19 06:05:05

Layla asks:

Good afternoon, I'm planning a pregnancy, I passed PCR for infections in 2 laboratories, everything is negative. I passed the ELISA for infections and found only mycoplasma, IgG 0.512 at a rate of 0.318. Do I need to be treated before pregnancy? By the way, 2-3 weeks before the analysis, she had been ill, had a runny nose and cough, it took about 2 weeks.
Title M has not yet passed.
And whether it is necessary to examine the child (I have a 2-year-old son), whether this infection can also be with him. A year ago, when my son was ill with bronchitis, the result was negative for mycoplasma pneumonia.
Thank you!

Responsible Medical laboratory consultant "Synevo Ukraine":

Good afternoon Leila. At you not a mycoplasma, but only class G antibodies to it is revealed. Those. there is no reason to talk about the presence of infection now. The results of the analyzes are always evaluated in conjunction with clinical data, in addition to have grounds for confirming a mycoplasma infection, retake IgG to mycoplasmas in the same laboratory 2-3 weeks after the first test. If there is no rise in antibody titer, forget that you have them. Be healthy!

2011-07-07 01:58:50

Xenia asks:

Hello. I have been worried about the temperature of 37.0-37.3 for 10 months. At first, pneumococcus 10 to 6 was treated. Cured, but the temperature did not drop. I passed the test for all infections, found mycoplasma pneumonia on PCR positive, on ELISA IgG-14 (normal up to 10), IgA-22.3 (normal up to 10). Treated with wilprofen for 10 days. A month later, she passed for PCR - negative, for ELISA IgG-23, IgM-5.5. The temperature doesn't go away. The condition after taking vilprofen improved slightly. In addition to temperature, persistent tonsillitis, pharyngitis, submandibular lymph nodes are enlarged, a strong reaction to cold. A swab from the throat is different, then streptococci SPP 10 in 6, then nisseria 10 in 5. The tonsils were washed, I go to the physio, the inflammation is removed a little, but nothing goes completely, constant perspiration and sore throat. Lor says it cannot give a temperature, the throat is normal. The kidneys hurt from time to time. Ultrasound - echogenicity of the parenchyma of the 1st degree, all other urinalysis, biochemistry is normal. The urologist says there is nothing to worry about. Question: is it necessary to treat mycoplasma further, to drink antibiotics, because. there are symptoms, or you can wait and get tested again, see if the titer drops. Can she pass by herself, are these indicators high and what do they talk about. Thank you.

Responsible Markov Igor Semenovich:

Hello Xenia. Mycoplasma (as before pneumococcus) has nothing to do with your temperature and does not need treatment. 2. The use of antibiotics is contraindicated for you. 3. Subfebrile condition is associated with chronic bacterial infection in the kidneys, which is confirmed by urine cultures. Further treatment is an autovaccine prepared from bacteria isolated during bacteriological cultures.

2011-01-20 08:30:08

Elena asks:

Good afternoon! I am 26. I hope very much for your help. 3 years sore throat (tickling, burning sensation, recently mostly in the morning), constant fatigue (+ I have been taking antidepressants for 1.5 months, Valdoxan). There is a reflux disease (sphincter does not work well, increased acidity). I am currently working and studying.

Analyzes handed over 3 times for EBV + mycoplasma pneumonia + chlamydia pneumonia + cytomegalo virus. I got sick with the herpes virus.

How to treat EBV? I have taken antibiotics 7-8 times in the last 3 years. And they said they didn’t prescribe anything against the virus and for the first time faced with such a case when active EBV was detected several times. Diagnosis: infectious mononucleosis. 3 years and no treatment? The cervical lymph nodes and the lymph nodes near the left breast are enlarged. Addressed to ENT doctors, infectious disease specialists. What specialist can you turn to? What is the prognosis in such a situation?

The possibility of malignant formations is very scary.

Analyzes 08.07.2010

CMV IgM- neg 0.39 (ref CMV IgG- pos >
Analyzes 05.10.2010

Analyzes 16.12.2010
Chlamydia pneumonia IgA pos 46.395 (neg Chlamydia pneumonia IgM neg 0.19 (neg Chlamydia pneumonia IgG pos 198.222 (neg Mycoplasma pneumonia IgA pos 13.429 (pos >12)) EIU
Mycoplasma pneumonia IgM pos 1.523 (pos>1.1) S/CO
Mycoplasma pneumonia IgG pos 216.356 (pos >45) EIU
HIV Ak+Ag neg 0.42 (ref CMV IgM- neg 0.348 (ref CMV IgG- pos >

I will be very grateful to you for your prompt reply.
Thank you in advance,
Elena

Responsible Medical laboratory consultant "Synevo Ukraine":

good day, Elena! And all this time you were treated only according to the results of these tests? Have you ever done a PCR test? If so, it's a pity, but you were treated incorrectly. If you continue to carry out repeated courses of antibiotic therapy, then not only your throat will start to hurt you. So, judging by the results of the tests, you are a lifelong carrier of CMV and HSV type 1. These viruses will remain in your body forever, it is impossible to get rid of their presence. Most of the time, viruses are dormant and do no harm. Occasionally, they can be activated, leading to the appearance of a rash, symptoms of SARS, etc. Before blaming herpesvirus infection, you need to reliably check its activity. It is very simple to do this, you just need to conduct a PCR blood test (CMV, HSV 1), urine and saliva (CMV) for the DNA of viruses. If there is viral DNA, go to an in-person appointment with an infectious disease specialist and conduct adequate antiviral therapy under his guidance. If there is no virus DNA, then the viruses are dormant, do no harm, do not require treatment. You have not yet met with HSV 2, you are not a carrier of this virus, the positive result obtained during the first study was false positive. If you then had a primary infection with HSV 2, now you would have IgG class antibodies to this virus in your blood. And you yourself see that you do not have them. Now about VEB. Judging by the results of the tests, you are really familiar with this virus, but if I were you, I would not say that you have been suffering from infectious mononucleosis for three years now. Let's figure it out. So, you have IgG antibodies to the EBV nuclear antigen (EBNA IgG) in your blood. But antibodies of this class are usually detected in the blood only after 1-3 months from the onset of infectious mononucleosis. Even after recovery in low titers, these antibodies in the blood persist throughout life. You do not have IgM to the capsid antigen (VCA) of EBV, and in fact they are a marker of acute infection. Since there are no antibodies of this class, then we cannot talk about acute EBV infection (infectious mononucleosis). As for IgG to the capsid antigen (VCA), at the threshold level, they can also be determined in the blood for life, after they appear in the blood in the first weeks after infection. And finally, IgM and IgG to early antigens (EA) are usually detected in the acute period of mononucleosis, circulating for about 2-3 months. Their longer circulation indicates a transition to a chronic form. In any case, you additionally need to conduct a PCR test of blood and saliva for EBV DNA. Only the presence of EBV DNA in your biological fluids can serve as confirmation of the activity of the process caused by EBV and serve as a reason for treatment (antiviral). In addition, I advise you to conduct a comprehensive diagnosis of dysbacteriosis, which you probably had before and significantly worsened after multiple courses of antibiotic therapy. Until you restore the local immunity of the mucous membranes, and their normal composition of the microflora, problems with the throat will not leave you. Be healthy!

2010-12-28 21:23:26

Elena asks:

Good afternoon! I am 26. I hope very much for your help. 3 years sore throat, constant fatigue (I take antidepressants for the 3rd week). Analyzes handed over 3 times for EBV + mycoplasma pneumonia + chlamydia pneumonia + cytomegalo virus. I got sick with herpes virus 1/2. HSV 2 is said differently, one doctor reported that infection had occurred. the second said that it was not infected. Perhaps there was an increase in the titer of HSV 2 IgM due to virus replication, since HSV 2 IgG is absent in repeated analyzes, or on the verge.

How to treat EBV? I have taken antibiotics 7-8 times in the last 3 years. But it's an antibacterial treatment. And they said they didn’t prescribe anything against the virus and for the first time faced with such a case when active EBV was detected several times. What can I do, no one can help me. Went to many doctors. What is the forecast? The possibility of malignant formations is very scary! What specialist can you turn to? I visited 3 infectious disease specialists, but no one prescribed antiviral therapy.

Analyzes 08.07.2010
HIV Ak+Ag neg 0.158 (ref HSV 1 IgM -neg 0.119 (neg 1.1) S/CO
HSV1 IgG-pos 3.122 (neg 1.1)S/CO
HSV2 IgM-pos 1.528 (neg 1.1)S/CO
HSV2 IgG -neg 0.758 (neg 1.1)S/CO
CMV IgM- neg 0.39 (ref CMV IgG-pos >500 (ref EBV VCA IgM- neg 0.014 (ref EBV VCA IgG-pos 10.643 (ref EBV EA IgM-pos 2.865 (ref EBV EA IgG-pos 1.235) (ref EBV NA IgG -pos 14.722 (ref
Analyzes 05.10.2010

HSV2 IgM-neg 0.507 (neg 1.1)S/CO
HSV2 IgG -neg 0.695 (neg 1.1)S/CO

Analyzes 16.12.2010

Chlamydia pneumonia IgA pos 46.395 (neg Chlamydia pneumonia IgM neg 0.19 (neg Chlamydia pneumonia IgG pos 198.222 (neg
Mycoplasma pneumonia IgA pos 13.429 (pos >12) EIU
Mycoplasma pneumonia IgM pos 1.523 (pos>1.1) S/CO
Mycoplasma pneumonia IgG pos 216.356 (pos >45) EIU

HIV Ak+Ag neg 0.42 (ref CMV IgM- neg 0.348 (ref CMV IgG- pos >500 (ref EBV VCA IgM- neg 0.1 (ref EBV VCA IgG-?
EBV EA IgM-pos 4.945 (ref EBV EA IgG-pos 1.332 (ref EBV NA IgG-pos 13.213 (ref
I will be very grateful to you for your prompt reply. I think, in my case, timely treatment is very useful.

Thank you in advance,

+ Collection of material 200 rubles.

+ Analysis at home from an adult (only Nizhny Novgorod) 200 rubles.

Description Preparation Indications Interpretation of results

Mycoplasma pneumoniae is the causative agent of respiratory mycoplasmosis. There are several options for the course of the infection - it can be either an infection of the upper respiratory tract (in the clinic - cough, runny nose, sore throat), and lower (in this case, there may be a worsening of the condition, up to an increase in shortness of breath and other signs of respiratory failure). Mycoplasma pneumonia (SARS) is a rather serious condition, especially in young children (infection is possible from 4 years or more). This microorganism is resistant to the most common antibacterial drugs due to the special structure of the cell wall and the possibility of intracellular reproduction. Therefore, diagnostics, namely, the determination of antibodies to Mycoplasma pneumonia allows you to prescribe adequate treatment in a timely manner and choose the appropriate drug.

Antibodies to Mycoplasma pneumoniae are synthesized in two classes - IgM and IgG. Antibodies to mycoplasma pneumonia of the IgM class are synthesized in the first weeks of the disease and disappear after 2-3 weeks. They allow the diagnosis of acute infection.

Antibodies to mycoplasma pneumonia IgG appear in the bloodstream 2-4 weeks after infection and remain in the blood for a long time (about a year). Thus, antibodies to mycoplasma pneumonia IgG characterize an acute infection that lasts a significant period of time (up to a month), or a mycoplasma infection that has been transferred in the near past.

Given that the determination of antibodies to Mycoplasma pneumoniae IgG is a fast and accurate diagnostic method, it is recommended that this test be performed for any suspicion of mycoplasma infection in order to obtain an informative picture of the disease.

There is no special preparation for testing for antibodies to Mycoplasma pneumoniae. It is necessary to refrain from food, physical and emotional stress for a day. And also, 30 minutes before taking the test for antibodies to Mycoplasma pneumonia, do not smoke.

Blood sampling is carried out 4 hours after the last meal.

In the presence of clinical symptoms of an infectious lesion of the respiratory tract - for the differential diagnosis of mycoplasmal and other infections
For the differential diagnosis of respiratory diseases caused by mycoplasma pneumonia and chronic non-specific lung diseases
To confirm the diagnosis of mycoplasma infection
To monitor the effectiveness of ongoing antibiotic therapy

Positive result for antibodies to Mycoplasma pneumoniae IgG:

Presence of acute mycoplasma infection (at least 2-4 weeks from onset)
Past mycoplasma infection within the last year

Negative for antibodies to Mycoplasma pneumoniae IgG

Absence of mycoplasma infection
Early terms of infection (the first 2-4 weeks of the disease)
The patient had a mycoplasma infection more than a year ago