"Neo-Penotran" (candles) - reviews. "Neo-Penotran" (vaginal suppositories): application

Almost every woman in her life at least once faced with sexual infections. The reasons for their development are different, the manifestations are always extremely unpleasant. When the analysis reveals not one, but several pathogens at once, doctors often prescribe treatment with the modern universal drug Neo Penotran Forte. It copes well with many diseases that have similar clinical manifestations: bacterial vaginosis, vaginitis, vaginal candidiasis, trichomonas infection. Even with such positive qualities, this medicine has its fly in the ointment - contraindications and high cost. Today on the site you will learn how to replace neo penotran forte if for some reason you cannot be treated with it. Stay with us!

Many vaginal suppositories for the treatment of gynecological diseases do not contain substances that would penetrate into the blood. The drug neopenotran forte contains metronidazole, which has a resorptive effect, about 20% of this component enters the blood - enough to cause side effects, therefore:

The drug is undesirable to use during lactation.
Do not use in the first months of pregnancy.
Cannot be used in liver failure.
Not recommended for under 18s.

The last restriction does not indicate a risk to the health of the very young, just that neopenotran has not been tested on younger patients.

Another reason to refuse the drug is taking certain medications. Simultaneous reception threatens with the appearance of side effects if you take:

Anticoagulants (warfarin), their effect will increase, the risk of bleeding will increase.
Disulfiram (for alcoholism) - psychosis, behavioral changes may occur. Cimetidine - there is a risk of negative effects on the nervous system.

This is a good reason to look for a replacement drug.

What can replace neo penotran candles

Klion-D 100

Klion D 100 - vaginal tablets based on miconazole and metronidazole. They have antifungal, antibacterial action. They are prescribed for local treatment of mixed type vaginitis.

Contraindicated in HB, allow the use in the second and third semester of pregnancy, strict no - the first three months.

The contraindications are the same as for penotran forte, so klion d 100 is its most accurate analogue. You can replace neopenotran with klion if, for example, you did not find the first one in the pharmacy. It's a slightly cheaper substitute.

Attention! Contraindications to the use are often due to the presence of metronidazole, part of which quickly penetrates into the blood, is absorbed into mother's milk. Absorption of miconazole is low.

Read in another article.

Metromicon Neo

The active substances of the drug are the same metronidazole and miconazole. The difference between Metromicon and Clion is a higher dose of metronidazole: Clione contains 100 mg per candle, Metromicon - all 500 mg. These suppositories can replace neo penotran forte, the use and dosage depend on the type and severity of the disease.

Attention! Before use, hands should be treated with an antiseptic or medical gloves should be used. The candle is introduced before going to bed, it is recommended to lie down for at least 30 minutes.

Gynocaps

Vaginal capsules, the active substances are the same as those of the previous preparations: 100 mg of metronidazole, 100 mg of miconazole nitrate. The capsules contain an oil suspension inside. They are prescribed for the treatment of mixed vaginitis caused by Trichomonas or Candida. Contraindications: the first three months of pregnancy, breastfeeding, liver failure.

metronidazole plus miconazole

Buy metronidazole and miconazole suppositories, use them together for treatment - this way you can replace neopenotran. By themselves, these medicines perfectly treat vaginal infections, which is proved by the reviews of many women. Contraindications are similar to those of previous drugs.

Fluomizin

Antiseptic for the treatment of genital infections: candidal and trichomonas vaginitis, bacterial vaginosis. Produced as vaginal tablets of 10 mg each. The main substance of fluomizin is dequalinium chloride. Tablets give a good effect, they can be used during pregnancy, not a hindrance and breastfeeding.

Attention! The excipients that this drug contains do not dissolve completely, so medication residues may be on the underwear. The effectiveness of the treatment does not suffer from this. Even with a quick result, it is necessary to complete the full course of 6 days so that there is no relapse.

Flagyl

Vaginal tablets with antibacterial action. Trichomonas and nonspecific vaginitis are treated. In fact, this is the same metronidazole - 500 mg, plus solid fat as an auxiliary substance. All contraindications are similar to contraindications of drugs containing them.

You cannot replace neo penotran forte during pregnancy in the first trimester, flagyl should not be taken in case of blood diseases, organic lesions of the nervous system.

clotrimazole

You can use clotrimazole vaginal tablets instead of neopenotran. It is an antifungal remedy for genital infections caused by the yeast Candida. Produced in suppositories, for treatment it is enough to enter one per day.

Do not use the first three months during pregnancy, during menstruation. Often prescribed for trichomoniasis, vulvovaginal candidiasis, thrush.

They have their own contraindications, are sold without a prescription.

Trichopolum

Another drug whose main active ingredient is metronidazole. The drug can be considered as a substitute for penotran. Vaginal tablets are effective for many types of genital infections. Before the introduction of the suppository must be moistened. The maximum duration of treatment is 10 days, repeated no more than 3 times a year.

Important! The medicine cannot be taken simultaneously with ethanol, it is not recommended to combine with amoxicillin if you are under 18 years old.

Livarol

The basis of livarol suppositories is ketoconazole. This antifungal drug can be used instead of Neo Penotran Forte suppositories for the treatment of acute or chronic vaginal candidiasis, mixed infections. Often prescribed as a prophylactic against the re-development of thrush, fungal vaginal infections that develop after long-term use of antibiotics.

Does not contain metronidazole, but is also contraindicated in the first three months of pregnancy.

Terzhinan

Penotran Forte can be replaced during breastfeeding with popular Terzhinan tablets, which are effective against bacterial and mixed vaginitis, vaginal trichomoniasis, and other vaginitis.

This is a good replacement for neo penotran forte with GV.

Vagiferon

Another antiseptic, anti-inflammatory, antifungal agent developed to combat vaginal infections. It copes well with Trichomonas, gonococci, chlamydia, herpes, but only in conjunction with complex therapy, antibiotics, acyclovir. The use of vagiferon suppositories alone is not enough for the desired effect.

Contraindicated in HB.

It differs in composition from neo-penotran in a lower dose of metronidazole: 150 mg versus 750 mg.

Attention! After the introduction of the suppository, it is necessary to lie down for 10 hours.

Ginalgin

Ginalgin treats inflammation of the vagina caused by the presence of bacteria, fungi, Trichomonas vaginalis.

Produced in tablets, it costs less than the main character of the article. Active substances: metronidazole, chlorquinaldol. Not suitable for pregnant women, should not be taken while breastfeeding. It differs from many analogues in that it is well tolerated, without discomfort. Ginalgin can not be combined with iodine-containing drugs, antiseptics. Few side effects are described, but there is a whole list of precautions, so read the instructions carefully.

Possible side effects when using, excluding driving a car, engaging in activities that require attention.

Important! If you are looking for a complete analogue of Neo Penotran Forte candles, take into account the drugs Metromicon, Ginocaps and Klion D 100. They can be called its exact copies.

After I went complaining of stomach pains, this clinic is near my house. Therefore, despite the shortcomings of this honey. I visit institutions from time to time on women's issues. The doctor prescribed tests, ultrasound, and according to their results, she said that I had a mixed flora and a cyst of the right ovary. She prescribed Neo-Penotran FORTE and re-admission in three weeks.

Neo-Penotran FORTE application

These are vaginal suppositories that should be used once a day for a week. It is necessary to apply the remedy in the late afternoon, so that after the introduction there is relative peace, otherwise you may not achieve the desired effect. Do not use during pregnancy, lactation, menstruation.

Neo-Penotran FORTE effectiveness

After the first application, there was a slight discomfort, slight itching and burning, which disappeared after half an hour after use. On the second and subsequent days of using the drug, no side effects were identified.

A second trip to the gynecologist and new tests and ultrasound showed no inflammation, no infection, no cysts. In general, the effectiveness of the drug is fully confirmed.

Neo-Penotran FORTE analogue

I started looking for an analogue only after buying the drug. It turns out that the main active ingredient Metronidazole is also contained in Trichopolum, but the latter does not contain the antifungal Miconazole. And here is a complete analog Neo-Penotran FORTE(Metronidazole + Miconazole) is Klion D and Klion D 100. Therefore, it is worth consulting with your doctor about a possible substitution for a cheaper drug.

Neo-Penotran FORTE instructions for use

Neo-Penotran FORTE price

The cost of the drug is 1011 rubles, so you should think about replacing the drug with a cheaper Klion D 100, which costs about 400-500 rubles. But again, I do not urge to replace the drug with an analogue without consulting a doctor.

Thank you for your attention!

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Medicine in the form of candles Neo Penotran is a traditional antifungal, antibacterial and antiprotozoal agent. This effect is due to the metronidazole and miconazole that are part of the drug. The first has an antifungal effect, and the second is endowed with fungicidal abilities.

Candles Neo Penotran forte can be replaced by two preparations similar in action and composition, they will be cheaper in cost, but will have the same strong effect, these are Klion D-100 and Metromicon. As for the rest of the analogues of Neo Penotran, they have similar pharmacological properties and are used to combat similar diseases.

Klion D-100

This drug is intended for intravaginal use. When the question arises of how to replace Neo Penotran, this is one of the best solutions to the problem. It costs only about 380 rubles, but it manifests itself as a fairly effective antibacterial and antifungal agent.

For what diseases should Klion D-100 be taken?

This Neo Penotran substitute is used to treat the following diseases:

Local treatment of thrush.
Vaginitis caused by Trichomonas.
Inflammatory processes in the pelvic area.
Candida vaginitis.
Bacterial vaginosis.

To whom is the drug contraindicated?

Side effects

The drug can cause nausea, vomiting, an unpleasant taste of metal in the mouth, as well as dizziness, drowsiness, or, in rare cases, leukopenia and neutropenia.

Important point! Klion D-100 can react with alcohol, therefore, at the time of its use, it is worth stopping all drinking.

Metromicon

Metromicon includes in its composition the same active substances as Neo Penotran, metronidazole and miconazole. This means that it is a completely similar drug, but its price is much lower, only 300 rubles.

Indications for the use of Metromicon

Doctors prescribe this medicine for the following diseases:

various forms of vaginitis;
genital infections;
thrush;
vaginal bacteriosis;
trichomoniasis;
vulvovaginitis;
urethritis;
mixed vaginal infections;
vaginal candidiasis.

Contraindications

Metromicon is not taken by pregnant women in the first trimester and women who are breastfeeding. Also, if the patient suffers from hypersensitivity to any components of the drug.

Note! While taking Metromicon, doctors do not recommend sexual intercourse. When it comes to the treatment of trichomoniasis, simultaneously with the patient, his sexual partner should be treated, taking systemic agents.

Neo Metronidazole

This analogue of Neo Penotran forte has an antiprotozoal and antifungal effect. It also has a high permeability, which allows reaching bactericidal concentrations of more tissues and body fluids, such as lungs, liver, brain, kidneys or bile.

What diseases does Neo Metronidazole treat?

The medicine, although it is one of the inexpensive means, because it is very difficult to find, it is actively fighting diseases such as:

Amoebiasis extraintestinal.
Infectious diseases of the joints and bones.
Fallopian tube abscesses.
Skin tissue infections.
Infections of the central nervous system.
Postoperative infections of the vaginal fornix.
Trichomoniasis.
Bacterial endocarditis.
Lung abscess.
Intestinal abscess.
Pneumonia.
Abscess of the ovaries.
Trichomonas vaginitis and urethritis.
Skin leishmaniasis.
brain abscess.
Giardiasis.
Amoebiasis intestinal.

Contraindications

The drug should not be taken by people suffering from hypersensitivity to the active substances of the drug, as well as from leukopenia, epilepsy, limited lesions of the nervous system. The medicine is not used in the first trimester of pregnancy and during breastfeeding.

Important! If treatment during pregnancy in the second or third trimester is necessary, it should be under the strict supervision of a physician. And also with extreme caution Metronidazole is taken by people with renal and hepatic insufficiency.

Ginalgin

In the production of Ginalgin, chlorquinaldol and metronidazole are used as active substances. They allow you to successfully treat the vagina from various inflammatory processes. You can buy Ginalgin via the Internet for 290-300 rubles.

What diseases does Ginalgin cope with?

The drug can be produced in the form of tablets and be active in the fight against diseases such as:

fungal vaginitis;
vaginitis provoked by mixed flora;
trichomonas vaginitis;
bacterial vaginitis.

What are the possible side effects?

The medicine may cause headaches or dizziness. Sometimes the patient suffers from itching, irritation in the vagina, frequent urination, pain, thick discharge with an odor that is either not pronounced or completely absent. In a sexual partner, at the end of sexual intercourse, there may be a burning sensation or itching, and, in rare cases, irritation of the penis. When the period of taking the drug is over, there is a risk of developing vaginal candidiasis.

To whom is Ginalgin contraindicated?

Doctors forbid taking Ginalgin if a woman suffers from blood diseases, epilepsy, lesions of the central nervous system, is in the period of lactation or pregnancy, and also if there is an allergic sensitivity to the active or auxiliary components of the drug.

Important advice! At the time of taking Ginalgin, doctors advise you to refrain from driving or from work that requires increased attention and quick response.

Vagiferon

When the use of Neo Penotran forte L analogues is required, Vagiferon can become one of them. This is a topical preparation, which is available in the form of candles. Women take them once a day after dinner before going to bed for 10 days. The advantage of the remedy is that it is safe, only in very rare cases, allergic reactions of the body to the substances that make up the drug can occur.

Indications for use

Vagiferon is taken by women with the appearance of the following diseases:

nonspecific bacterial vaginitis;
vaginitis accompanied by mixed infections, such as trichomonas, herpes of the first and second types, gardnerella or yeast-like fungi;
bacterial vaginosis;
as a complex therapy against vaginal candidiasis.

When should Vagiferon not be taken?

The drug is prohibited for use if it can cause an allergic reaction in the patient; during lactation, breastfeeding should be stopped for the duration of the drug, and resumed only after 48 hours after using the drug.

Since the features of the drug's action and its safety at an early age have not been studied, doctors do not prescribe Vagiferon for girls under 18 years of age.

Livarol

Livarol is one of the most distant analogues of Neo Penotran, since its active substance is ketoconazole. The medicine is produced exclusively in the form of a white suppository or with a grayish, yellow and creamy tint.

When should I take Livarol?

This drug has gained quite a lot of popularity due to the effective fight against the following diseases:

Complex form of thrush;
Vaginal candidiasis;
Various forms of violation of the vaginal microflora;
Mixed infectious agents.

Contraindications

When it comes to the treatment of thrush, the patient should consult a doctor before taking it and undergo treatment under his supervision if she is under 13 years old or while breastfeeding.

Livarol is completely prohibited if the woman is pregnant in the first trimester. In addition to allergic reactions, which occurred quite rarely, no side effects were found.

Conclusion

Any drug, as well as its alternative options, should never be selected independently. If for some reason Neo Penotran has not been effective or is not available due to its price, the selection of an analogue must be discussed with the doctor. Only after taking into account the peculiarities of the body's reaction to the components of a particular drug, you can think about buying and taking it further.

Neo-Penotran Forte- a remedy in the form of suppositories with antifungal, antiprotozoal and antibacterial effect for local therapy in gynecological practice.

Suppositories include two active ingredients:, and miconazole nitrate, which has antifungal activity.

Analogues Neo-Penotrana Forte

Structural analogues, including the same active ingredients:

Klion D

Indications: local therapy of mixed vaginal infections caused by Trichomonas and fungi of the genus Candida.

Metromizol

Indications: local treatment of vulvovaginal candidiasis and bacterial vaginitis.

Metromicon-Neo

Indications: local treatment of vaginal infections: bacterial vaginosis, vulvovaginitis, trichomonas vaginitis, vaginal candidiasis, mixed infections.

Metromicon

Indications: local treatment of vulvovaginal and vaginal candidiasis, urethritis, trichomonas vaginitis.

Neo-Penotran

Indications: local therapy of vaginal candidiasis, Trichomonas and bacterial vaginitis.

Means that have a different active substance, but have a similar therapeutic effect.

Ginalgin (chlorquinaldol + metronidazole)

Indications: fungal vaginitis, bacterial vaginitis, trichomonas vaginitis, as well as a combination of infections.

Pulsitex (miconazole nitrate + tinidazole + neomycin sulfate)

Indications: local therapy of vaginal trichomoniasis, bacterial, fungal, protozoal and mixed vulvovaginitis,.

Means of this pharmacological group are well tolerated by patients. Sometimes local reactions are possible in the form of irritation of the mucous membrane, burning and itching. In rare cases, nausea, diarrhea, headache, dizziness occur.

Contraindications: 1st trimester of pregnancy, lactation, intolerance to these drugs.

Self-medication can be harmful to your health.
It is necessary to consult a doctor, and also read the instructions before use.

Neo-Penotran: instructions for use

Compound

Each vaginal suppository contains:

- active substances: 500 mg metronidazole and 100 mg miconazole nitrate

- Excipients: 1900 mg Witepsol S 55.

Description

Vaginal suppositories in the form of a flat body with a rounded end, white or almost white.

pharmachologic effect

Pharmacotherapeutic group

Antimicrobial combined agent (antimicrobial and antiprotozoal agent + antifungal agent). Code ATX G01AF20

Pharmacodynamics

Neo-Penotran contains miconazole nitrate and metronidazole. Miconazole nitrate has a wide spectrum of activity and is especially effective against pathogenic fungi, including Candida albicans, in addition, miconazole nitrate is effective against gram-positive microbes. Metronidazole is an antimicrobial and antiprotozoal agent effective against Gardnerella vaginalis and anaerobic microbes, including anaerobic streptococci and Trichomonas vaginalis.

Pharmacokinetics

Absorption of miconazole nitrate from the vagina is very low (approximately 1.4% of the dose). The bioavailability of metronidazole with this route of administration compared with oral administration is 20%. After the introduction of the Neo-Penotran® suppository into the vagina, miconazole nitrate was not detected in plasma; the level of metronidazole in plasma at an equilibrium concentration reached 1.6 - 7.2 μg / ml. Metronidazole is metabolized in the liver. The hydroxyl metabolite is active. The half-life of metronidazole is 6-11 hours. Approximately 20% of this dose is excreted unchanged in the urine.

Indications for use

Local treatment:

vaginal candidiasis,

Trichomonas vulvovaginitis,

Bacterial vaginosis (also called nonspecific vaginitis, anaerobic vaginosis, or gardnerella vaginitis),

Mixed vaginal infection.

Contraindications

Hypersensitivity to the components of the drug, the first trimester of pregnancy, porphyria, epilepsy, severe liver dysfunction.

Pregnancy and lactation

The use of the drug is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus and child.

During treatment with Neo-Penotran, breastfeeding should be discontinued, as metronidazole is excreted in milk. Breastfeeding can be resumed 24-48 hours after the end of treatment.

Dosage and administration

For recurrent vaginitis or vaginitis resistant to other treatment: 1 vaginal suppository at night and 1 vaginal suppository in the morning for 14 days.

Vaginal suppositories must be inserted deep into the vagina using the disposable fingertips contained in the package.

Elderly patients (over 65): the same recommendations as for younger adult patients.

Cannot be taken orally.

For intravaginal use only.

Side effect

In rare cases, hypersensitivity reactions (skin rash) and side effects such as abdominal pain, headache, vaginal itching, burning and irritation of the vagina may occur. The incidence of systemic side effects is very low, since with vaginal use of metronidazole contained in Neo-Penotran vaginal suppositories, the plasma concentration of metronidazole is very low (2-12%). Miconazole nitrate, like all other antifungal agents based on imidazole derivatives that are injected into the vagina, can cause vaginal irritation (burning, itching) (2-6%). Due to inflammation of the vaginal mucosa with vaginitis, vaginal irritation (burning, itching) may increase after the introduction of the first suppository or by the third day of treatment. These complications quickly disappear as treatment continues. If there is severe irritation, the use of the drug should be discontinued. Side effects due to the systemic use of metronidazole include hypersensitivity reactions (rarely); leukopenia; ataxia; psychoemotional disorders; peripheral neuropathy in overdose and prolonged use; convulsions; diarrhea, dizziness (rare); headache; loss of appetite; nausea; vomit; pain or cramps in the abdomen; change in taste sensations (rare); constipation; dry mouth; metallic taste; increased fatigue. These side effects are observed very rarely, due to the low concentration of metronidazole in the blood during the intravaginal use of Neo-Penotran suppositories. Miconazole nitrate is not absorbed after the introduction of Neo-Penotran suppositories into the vagina.

Overdose

Data on overdose in humans with intravaginal use of metronidazole are not available. After intravaginal administration, metronidazole may be absorbed in sufficient amounts to cause systemic effects.

In case of accidental ingestion of large doses of the substance, if necessary, gastric lavage can be performed. Treatment can be given to persons who have taken 12 g of metronidazole orally. There is no specific antidote. Symptomatic and supportive therapy is recommended.

Symptoms of an overdose of metronidazole: nausea, vomiting, abdominal pain, diarrhea, itching, metallic taste in the mouth, movement disorders (ataxia), dizziness, paresthesia, convulsions, leukopenia, dark urine color.

Symptoms of an overdose of miconazole nitrate: nausea, vomiting, inflammation of the throat and mouth, loss of appetite, headache, diarrhea.

Interaction with other drugs

As a result of the absorption of metronidazole, interactions with the drugs listed below may occur.

Alcohol. The interaction of metronidazole with alcohol causes disulfiram-like reactions.

Oral anticoagulants. The effect of indirect anticoagulants is enhanced.

Phenytoin: The level of phenytoin in the blood increases, the level of metronidazole in the blood decreases.

Phenobarbital: Reduces blood levels of metronidazole.

Disulfiram: There may be changes in the central nervous system (mental reactions).

Cimetidine: The level of metronidazole in the blood may increase and, therefore, the risk of neurological side effects will increase.

Lithium: There may be an increase in lithium toxicity.

Astemizole and terfenab Metronidazole and miconazole inhibit the metabolism of these drugs and increase plasma concentrations.

There is an effect on blood levels of liver enzymes, glucose (when determined by the hexokinase method), theophylline and procainamide.

Application features

It is necessary to avoid alcohol during treatment and at least for 24-48 hours after the end of the course due to possible disulfiram-like reactions. Caution should be exercised when using suppositories simultaneously with contraceptive diaphragms and condoms due to the possible interaction of rubber with the suppository base.

Patients diagnosed with trichomonas vulvovaginitis require simultaneous treatment of the sexual partner.

Do not swallow or otherwise apply!

Influence on the ability to drive a car and control complex mechanisms