Nurofen n instructions for use. Nurofen - official instructions for use

1. Pharmacological action

Nurofen is rapidly absorbed and distributed throughout all tissues in a short time, lingering mainly in the periarticular fluid, where its maximum concentration is reached. This property of the drug is due to the high degree of binding to plasma proteins (about 90%). The drug enters the joint cavity to a small extent or does not enter at all.

Neutralization of Nurofen occurs in the liver with the formation of active decay products. Its excretion occurs with the help of the kidneys and bile. The time of excretion of the drug from the body is about 4 hours.

2. indications for use

• Pain syndrome of various localization and severity;
• Feverish conditions with viral infections;
• Rheumatoid diseases of the organs of the musculoskeletal system;
• Inflammatory processes in infectious diseases of the ENT organs.

3. How to use

The drug is prescribed only for patients whose body weight exceeds 20 kg.

The dosage of Nurofen is as follows: 200 mg of the drug no more than 4 times a day with an interval between doses of at least 6 hours.

Dosage of Nurofen in the form of tablets for pediatric patients, over 12 years old and adult patients

The initial dosage of the drug is 200-400 mg with a gradual decrease after reaching the desired effect. The frequency of use of Nurofen - no more than 4 times a day.
In both cases, the maximum dosage of Nurofen is 1.2 g per day.

• Coated tablets are taken after meals and washed down with a sufficient amount of warm drinking water or milk;
• Soluble tablets dissolve in a glass of warm water and are taken immediately after a meal.

Application of Nurofen in the form of an ointment or gel:

The drug is applied in a thin layer to the affected areas and rubbed until it is completely absorbed. The frequency of application of Nurofen - no more than 4 times a day, and when the positive dynamics of the treatment process is achieved - no more than 2 times a day.

4. Side effects

• Nervous system disorders (sleep disorders, prolonged mood decline, headaches, dizziness, drowsiness, hallucinations, confusion, drug, increased nervous excitability);
• Respiratory system disorders (shortness of breath, bronchospasm);
• Violations of the urinary system (functional insufficiency of the activity of the kidneys in the acute stage, inflammation of the kidneys, inflammation of the bladder, frequent urge to urinate);
• Disorders of the cardiovascular system (increased blood pressure, cardiac arrhythmias, functional heart failure);
• Disorders of the digestive system (prolonged loss of appetite or its complete absence, vomiting, heartburn, nausea, ulcerative lesions of organs, pain in the abdomen, stool disorders, inflammation of the oral cavity, inflammation of the pancreas, various irritations of the oral cavity and other organs, inflammation of the liver );
• Metabolic disorders (increased sweating);
• Disturbances of the sense organs (various visual disturbances, various hearing impairments, ringing in the ears, inflammation of the conjunctival membrane of the eyes, dryness of the eyeballs, swelling);
• Various allergic reactions (, Lyell's syndrome, Stevens-Johnson syndrome);
• Disorders of the hematopoietic system (decrease in the percentage of leukocytes, a decrease in the percentage of platelets, anemia, an increase in the percentage of agranulocytes).

5. Contraindications

• Various disorders of the hematopoietic system;
• Severe functional insufficiency of the activity of the heart;
• Hypersensitivity to the drug and its components;
• Congenital or acquired deficiency of the enzyme glucose-6-phosphate dehydrogenase;
• aspirin asthma;
• Prolonged increase in blood pressure in a severe stage;
• Individual intolerance to the drug and its components;
• Various hearing impairments;
• Various diseases of the hearing organs;
• Pregnancy and lactation;
• Severe functional disorders of the kidneys;
• Age of patients less than 6 years;
• Reducing the percentage of leukocytes;
• Various diseases of the organs of vision;
• Various diseases of the optic nerve;
• Severe functional disorders of the liver.

6. During pregnancy and lactation

The use of Nurofen during lactation should occur only after a complete rejection of it.

7. Interaction with other drugs

• The simultaneous use of Nurofen with Acetylsalicylic acid leads to a decrease in the therapeutic effect of the latter;
• Simultaneous use of Nurofen with drugs that reduce the ability of blood to coagulate leads to the risk of bleeding of various localization;
• The simultaneous use of Nurofen with Cyclosporine leads to an increase in the toxic effects of the latter and the development of toxic kidney damage;
• The simultaneous use of Nurofen with Plikamycin, Cefamandol, Cefotetan, Cefoperazone and Valproic acid leads to a decrease in the content of prothrombin in the blood plasma;
• The simultaneous use of Nurofen with drugs that block or reduce macrosomal oxidation of substances in the body leads to the development of severe liver poisoning;
• The simultaneous use of Nurofen with drugs that reduce tubular secretion of the kidneys leads to an increase in the concentration of Nurofen in the blood plasma and the development of corresponding side effects;
• The simultaneous use of Nurofen with drugs that reduce the concentration of hydrochloric acid in gastric juice and Colestyramine leads to a decrease in the absorption of Nurofen;
• The simultaneous use of Nurofen with drugs that reduce glucose in the form of tablets leads to an increase in the therapeutic effect of the latter;
• The simultaneous use of Nurofen with drugs containing caffeine leads to an increase in the analgesic effect of Nurofen.

8. Overdose

• Disorders of the digestive system (pain in the abdomen, vomiting, nausea);
• Disorders of the cardiovascular system (cardiac arrhythmias, lowering blood pressure, atrial arrest);
• Disorders of the nervous system (persistent long-term lowering of mood, sensation of tinnitus, headaches, decreased reactivity, drowsiness,);
• Respiratory system disorders (respiratory arrest);
• Violations of the urinary system (functional insufficiency of the activity of the kidneys in an acute form).

9. Release form

10. Storage conditions

Shelf life - no more than 3 years.

11. Composition

100 g gel:

• - 5 g;
• Excipients: hyetellose, sodium hydroxide, benzyl alcohol, isopropyl alcohol, purified water.

1 tablet:

• - 200 mg;
• Excipients: croscarmellose sodium, sodium lauryl sulfate, sodium citrate dihydrate, stearic acid, colloidal silicon dioxide.

suspension 5 ml:

• - 100 mg;
• Excipients: maltitol syrup, water, glycerol, citric acid, sodium citrate, sodium chloride, sodium saccharinate, xanthan gum, strawberry flavor 500244E, polysorbate, domifene bromide.

12. Terms of dispensing from pharmacies

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* Instructions for medical use for Nurofen are published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, IT IS NECESSARY TO CONSULT WITH A SPECIALIST

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Nurofen is a drug from the group of non-steroidal anti-inflammatory drugs(NSAIDs), which has analgesic, anti-inflammatory and antipyretic effects in various pathological conditions and diseases. Therefore, Nurofen is used as a symptomatic agent in the complex therapy of various diseases accompanied by pain, inflammation in the tissues and fever. So, Nurofen is used to eliminate painful symptoms (pain, fever and inflammation) with influenza, acute respiratory infections, acute respiratory viral infections, head, dental, muscle, joint and menstrual pains, with severe sore throat, neuralgia, migraines, as well as damage to ligaments, muscles and sports injuries.

Varieties, names and forms of release of Nurofen

• Nurofen;
• Nurofen Active;
• Nurofen for children (children);
• Nurofen Period;
• Nurofen Plus;
• Nurofen Plus N;
• Nurofen Ultracap;
• Nurofen Ultracap Forte;
• Nurofen Forte;
• Nurofen Express;
• Nurofen Express Neo.

Varieties of Nurofen are available in the following dosage forms:

• Nurofen - tablets for oral administration, effervescent tablets for solution and gel for external application;
• Nurofen Active - lozenges;
• Nurofen for children - oral suspension and rectal suppositories;
• Nurofen Period - prolonged action tablets;
• Nurofen Plus and Nurofen Plus N - coated tablets;
• Nurofen Ultracap and Ultracap Forte - capsules for oral administration;
• Nurofen Forte - tablets;
• Nurofen Express - capsules and tablets;
• Nurofen Express Neo - sugar-coated tablets.

Nurofen - composition

• Oral tablets and effervescent tablets for the preparation of Nurofen solution;
• Tablets Nurofen Active;
• Tablets Nurofen Plus and Plus N;
• Capsules Nurofen Ultracap;
• Tablets Nurofen Express and Express Neo.

Other varieties and formulations of Nurofen contain ibuprofen in the following dosages:

• Gel Nurofen for external application - 5% (5 g of ibuprofen per 100 g of the finished product);
• Nurofen for children - suppositories 60 mg per suppository and 100 mg per dose of suspension (100 mg per 5 ml);
• Nurofen Period - 300 mg ibuprofen per long-acting tablet;
• Nurofen Forte - 400 mg per tablet;
• Nurofen Ultracap Forte - 400 mg per capsule.

Therapeutic action

All these effects of Nurofen are provided by its ability to block the enzyme cyclooxygenase-2 , which catalyzes the process of formation of special substances - prostaglandins . Prostaglandins, in turn, are substances that cause pain, inflammation in tissues, as well as an increase in overall body temperature or a local sensation of heat in the area of ​​injury. That is, Nurofen simply stops the synthesis of biologically active substances that cause pain, inflammation and fever, thereby eliminating these symptoms.

Nurofen - indications for use

So, all forms of Nurofen for oral administration are indicated for use in the management of pain, fever and inflammation in the presence of the following diseases or conditions:

• Arthritis of various types, accompanied by pain and inflammation of the joints (rheumatoid arthritis, psoriatic arthritis, osteochondrosis, arthritis with systemic lupus erythematosus);
• Neuralgic amyotrophy;
• Ankylosing spondylitis (Bekhterev's disease);
• Pain syndrome of any localization, regardless of the causative factor (toothache, headache, menstrual pain, pain in muscles, bones and joints, sciatica, migraine, bursitis, tendonitis, tendovaginitis, etc.);
• Pain after surgery or injury;
• Pain in malignant tumors;
• painful menstruation;
• Pain in the inflammatory process in the pelvis (for example, adnexitis, endometritis, etc.);
• Pain in childbirth;
• As a drug to suppress the contractile activity of the uterus with the threat of premature birth;
• Temperatures in infectious diseases or colds.

It should be remembered that Nurofen is indicated only for symptomatic therapy in order to reduce pain and inflammation, but it does not affect the cure or improve the course of the disease. Therefore, in addition to Nurofen, specialized medicines are needed for treatment.

Gel Nurofen indicated for topical use in the following conditions or diseases:

• Muscle pain;
• Arthritis;
• Ligament injuries;
• Injuries while playing sports;
• Neuralgia.

Nurofen for children - indications for use

• Flu;
• childhood infections;
• Vaccination reactions.

• Headache;
• Toothache;
• Migraine;
• Neuralgia;
• Pain after injuries of muscles, tendons, joints, ligaments and bones.

Instructions for use

Nurofen tablets and capsules - instructions for use

If within 2-3 days from the start of taking Nurofen the pain, inflammation or fever does not go away, then you should stop the drug and consult a doctor immediately. It is also necessary to stop taking Nurofen and consult a doctor if side effects occur.

If it is necessary to take drugs containing steroid hormones, Nurofen should be canceled two days in advance. In addition, during the entire period of taking Nurofen, you must refrain from drinking alcohol.

During the entire period of therapy with Nurofen, it is necessary to take a general and biochemical blood test regularly, at least once every 1 to 2 weeks, to determine the activity of liver enzymes (AST, ALT), as well as the concentration of urea and creatinine. If abnormalities occur, stop taking the drug and consult a doctor. Also, during the entire course of therapy with Nurofen, it is necessary to monitor the condition of the stomach, since the drug can provoke gastropathy. If there is a suspicion of gastropathy (unpleasant symptoms from the stomach), it is necessary to undergo an examination, according to the results of which the doctor will decide whether to continue or suspend therapy.

Dosages and duration of taking Nurofen depend on the disease for which the drug is taken to eliminate the symptoms.

To relieve dental, menstrual, muscle, traumatic and other non-permanent pain, adults and children over 12 years of age should take Nurofen 200 mg tablets or capsules 3 to 4 times a day. In order to obtain the fastest effect, Nurofen can be taken 400 mg 3 times a day. Long-acting tablets (Nurofen Period) should be taken at 300 mg twice a day. Children from 6 to 12 years old can be given Nurofen 200 mg no more than 4 times a day. That is, the maximum allowable dosage for children 6-12 years old is 800 mg. In addition, it must be remembered that "adult" varieties of Nurofen can only be given to those children whose body weight is more than 20 kg. Children weighing less than 20 kg should only be given children's Nurofen.

The interval between taking conventional tablets and capsules should be at least 6 hours, and prolonged-release tablets - at least 12 hours. The maximum daily dosage of Nurofen in tablets and capsules is no more than 1200 mg (1.2 g).

In severe chronic diseases accompanied by pain and inflammation, Nurofen should be taken for a long time in the following dosages:

• Osteoarthritis, arthritis, ankylosing spondylitis - take 400-600 mg 3-4 times a day.
• Rheumatoid arthritis - take 800 mg 3 times a day.
• Juvenile rheumatoid arthritis - the dosage is calculated individually, based on the ratio of 30-40 mg per 1 kg of body weight. The total calculated dosage is divided into 3-4 doses per day.
• Soft tissue injuries (muscles, ligaments, tendons) - take 400-600 mg 4 times a day every 6 hours.
• With painful menstruation - take 400 mg 3 to 4 times a day.

Nurofen for children (syrup and suppositories) - instructions for use

For children over 12 years of age, Nurofen is given 150–300 mg (7.5–15 ml of solution) 3 times a day in order to reduce temperature and relieve pain, and after relief of symptoms and improvement in the condition, the dosage is reduced to 100 mg (5 ml) according to 3 times a day. The maximum allowable daily dosage of Nurofen for children over 12 years of age is 1000 mg (1 kg).

In juvenile rheumatoid arthritis, the dosage of the suspension is calculated individually according to body weight, based on the ratio of 30-40 mg per 1 kg of weight. The calculated dosage is divided into three doses per day.

In order to reduce the temperature and symptomatic treatment of childhood infections, colds, SARS and other similar conditions, Nurofen is given to a child in the following dosages, depending on age:

• Children aged 3-6 months - 50 mg (2.5 ml suspension) three times a day;
• Children 6-12 months - 50 mg (2.5 mg) 3-4 times a day;
• Children 1-3 years old - 100 mg (5 ml) 3 times a day;
• Children 4-6 years old - 150 mg (7.5 ml) 3 times a day;
• Children 7-9 years old - 200 mg (10 ml) 3 times a day;
• Children 10-12 years old - 300 mg (15 ml) 3 times a day.

With an increase in temperature after vaccination, you can give the child 2.5 ml of the suspension once. After 6 hours, if necessary, you can give the child another 2.5 ml of the suspension. More than 5 ml of Nurofen syrup per day should not be given to a child in order to reduce the temperature after vaccination.

Rectal suppositories in children are used for the same purpose as syrup. Suppositories can be chosen if the baby is unable to swallow the solution for any reason, for example, the child is vomiting, and therefore the syrup cannot be taken. Also, candles are preferable if you need to get a quick effect.

Candles are inserted into the anus of the child, gently pushing the index finger of the hand. The suppository must be pushed to the inner border of the sphincter, for which it should be inserted with a finger to the middle of the second phalanx.

For children aged 3-9 months, in order to reduce temperature and relieve pain, 1 suppository is administered 3 times a day. And for children aged 9 months - 2 years, one suppository is administered 4 times a day, every 6 hours.

In order to reduce the temperature that has risen after vaccination, 1 suppository is administered to children. Children older than 1 year, if necessary, you can enter another candle, but only 6 hours after using the first one.

The duration of the use of suppositories and suspensions of children's Nurofen to reduce the temperature is a maximum of 3 days, and for pain relief - 5 days.

Nurofen suppositories and suspension can be used in children with diabetes because they do not contain sugar. With caution, it is necessary to use children's forms of Nurofen if the child has a past or present gastric ulcer, gastritis, ulcerative colitis, bleeding from the digestive tract, urticaria, bronchial asthma, eczema, as well as pathology of the liver and kidneys. You should also be careful when taking Nurofen with other painkillers, diuretics, antihypertensive drugs, as well as anticoagulants (drugs that reduce clotting), methotrexate and lithium compounds.

If a child develops side effects of Nurofen, it is necessary to stop using the drug and consult a doctor.

Nurofen gel - instructions for use

For a single application, 4-10 cm of gel is squeezed out of the tube and gently distributed over the area of ​​​​the skin with light massage movements, rubbing until completely absorbed into the skin. The gel can be used a maximum of 4 times a day, observing the interval between rubbing into the skin for at least 4 hours. If within two weeks after the start of using the gel, the condition has not improved, then its use should be discontinued and consult a doctor.

After applying the gel to the skin, wash your hands with soap and dry. In the process of applying the gel, it is necessary to avoid getting it into the eyes, lips and mouth. If the gel accidentally gets into the eyes, lips or mouth, then rinse them with cold running water.

Nurofen in the form of a gel should not be applied to areas of skin with wounds and other injuries, as well as to the areas around the eyes and lips.

Influence on the ability to control mechanisms

Overdose

So, the symptoms of an overdose of Nurofen are as follows:

• Nausea;
• Vomit;
• lethargy;
• Depression;
• Decreased blood pressure;
• Tachycardia;
• Atrial fibrillation;
• Stop breathing;
• Acute renal failure.

Interaction with other drugs

Firstly, it is not recommended to use Nurofen in conjunction with other drugs from the NSAID group (Aspirin, Paracetamol, Ketorol, Nimesulide, etc.).

With the simultaneous use of Nurofen with drugs to reduce blood clotting (anticoagulants) and dissolve blood clots (thrombolytics), their effects are enhanced, which can provoke bleeding.

The simultaneous use of Nurofen in combination with antidepressants from the group of serotonin reuptake inhibitors (Citalopram, Fluoxetine, Paroxetine, Sertraline, etc.) increases the risk of bleeding from the digestive tract.

Combined use with Cefamandol, Cefoperazone, Cefotetan, Valproic acid and Plikamycin disrupts normal blood clotting.

Nurofen enhances the severity of side effects of glucocorticosteroids, mineralocorticoids, estrogens and ethyl alcohol.

Nurofen during pregnancy

In the last months of pregnancy, Nurofen should not be used, as this can provoke fetal pathology - non-closure of the duct between the ventricles of the heart, as well as post-maturity and complications in childbirth. Fetal ductus occlusion is treatable, but it is better to prevent it than to eliminate it later. And postnatalization and complications in childbirth can provoke various damage to the fetus, which are also best avoided. Therefore, it is not recommended to use Nurofen during the last month of pregnancy.

During pregnancy, to relieve pain, reduce inflammation and normalize body temperature, Nurofen is used in normal adult dosages, that is, 200 mg 3 to 4 times a day. It is not recommended to increase the dosage of Nurofen up to 400 mg 4 times a day. One-time, if it is necessary to relieve pain, pregnant women should take Nurofen 200 mg. If there is no improvement within an hour, then you can take another 200 mg of Nurofen. The next appointment can be made no earlier than 6 hours later. If Nurofen is prescribed by a gynecologist for the prevention of preterm labor, then the drug should be taken according to the prescribed regimen.

During pregnancy, Nurofen should not be used by women who suffer from bronchial asthma, heart failure, bleeding disorders, liver, kidney and hearing diseases, as well as high blood pressure.

Nurofen for pain

Nurofen for pain is recommended to take 200-400 mg every 6 hours, but not more than 4 times a day. Nurofen Plus and Nurofen Plus N have the most powerful analgesic effect, since in addition to ibuprofen they contain codeine, which enhances the analgesic effect of the former.

Does Nurofen bring down the temperature?

Side effects

Tablets and capsules (for adults)

• Nausea;
• Vomit;
• Feeling of discomfort in the stomach;
• Diarrhea;
• Erosive and ulcerative lesions of the mucous membrane of the digestive tract;
• Abdominal pain;
• Irritation and dryness of the oral mucosa;
• ulceration of the gums;
• Aphthous stomatitis;

• Headache;
• confusion;
• Dizziness;
• Insomnia;
• Excitation;
• Drowsiness;
• Depression;
• Aseptic meningitis (in people suffering from autoimmune diseases).

• Reversible optic neuritis;
• Blurred vision;
• Diplopia (doubling of objects before the eyes);
• Dryness and irritation of the mucous membrane of the eye;

It has a local analgesic and anti-inflammatory effect. The mechanism of action is due to the inhibition of the synthesis of PG - mediators of pain and inflammation.

Pharmacokinetics of Nurofen

When taken orally, it is well absorbed from the gastrointestinal tract. Cmax is created within 1 hour, when taken after meals - within 1.5–2.5 hours. Plasma protein binding is 90%. It slowly penetrates into the joint cavity, but lingers in the synovial tissue, creating higher concentrations in it than in plasma. The biological activity is associated with the S-enantiomer. After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form. undergoes biotransformation. There are 3 main metabolites excreted by the kidneys. No more than 1% is excreted unchanged in the urine. It has a two-phase elimination kinetics with T1 / 2 from plasma 2-2.5 hours (for retard forms - up to 12 hours).

Use of Nurofen during pregnancy

Caution should be exercised during pregnancy and while breastfeeding.

Contraindications to the use of the drug Nurofen

hypersensitivity to ibuprofen, acetylsalicylic acid, other NSAIDs;

Bronchial asthma, urticaria, rhinitis, provoked by the intake of acetylsalicylic acid (salicylates) or other NSAIDs;

Children's age (up to 12 years).

Carefully:

Concomitant diseases of the liver or kidneys, gastrointestinal tract;

Bronchial asthma, urticaria, rhinitis, polyps of the nasal mucosa.

Side effects of Nurofen

stomach), irritation, dryness of the mucous membrane or pain in the oral cavity, ulceration of the mucous membrane of the gums, aphthous stomatitis, pancreatitis, constipation / diarrhea, flatulence, indigestion, possibly erosive and ulcerative lesions and bleeding from the gastrointestinal tract, impaired liver function.

From the nervous system and sensory organs: headache, drowsiness, anxiety, nervousness, irritability, psychomotor agitation, confusion, hallucinations, aseptic meningitis (more often in patients with autoimmune diseases), hearing loss, tinnitus, reversible toxic amblyopia, unclear vision or double vision, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic genesis), scotoma.

From the side of the cardiovascular system and blood (hematopoiesis, hemostasis): heart failure, tachycardia, increased blood pressure, eosinophilia, anemia, incl. hemolytic, thrombocytopenic purpura, agranulocytosis, leukopenia.

From the respiratory system: shortness of breath, bronchospasm.

From the genitourinary system: edematous syndrome, impaired renal function, acute renal failure, polyuria, cystitis.

Allergic reactions: skin rash (erythematous, urticarial), pruritus, urticaria, allergic rhinitis, allergic nephritis, Quincke's edema, anaphylactic reactions, incl. anaphylactic shock, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis.

Other: increased sweating, fever.

Dosage and administration of Nurofen

inside. Adults and children over 12 years old - 1 tab. (200 mg) 3-4 times a day. To achieve a rapid therapeutic effect, the dose is increased to 2 tablets. (400 mg) 3 times a day. Do not take more than 6 tablets. in 24 hours

Children 6–12 years old (weighing more than 20 kg) - 1 table. no more than 4 times a day.

The maximum daily dose is 1200 mg.

Overdose of Nurofen

Symptoms: abdominal pain, nausea, vomiting, lethargy, drowsiness, depression, headache, tinnitus, metabolic acidosis, coma, acute renal failure, hypotension, bradycardia, tachycardia, atrial fibrillation and respiratory arrest.

Treatment: gastric lavage (only during the first hour after ingestion), activated charcoal (to reduce absorption), alkaline drinking, forced diuresis and symptomatic therapy (correction of acid-base balance, blood pressure, gastrointestinal bleeding)

Interactions of the drug Nurofen with other drugs

The simultaneous use of two or more NSAIDs should be avoided due to an increased risk of side effects. With the simultaneous use of ibuprofen, it reduces the anti-inflammatory and antiaggregatory effect of acetylsalicylic acid (it is possible to increase the incidence of acute coronary insufficiency in patients receiving low doses of acetylsalicylic acid as an antiplatelet agent after starting ibuprofen). When used with thrombolytic drugs (alteplase, streptokinase, urokinase), the risk of bleeding increases at the same time. Ibuprofen enhances the effect of indirect anticoagulants, antiplatelet agents, fibrinolytics.

Microsomal oxidation inducers (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of severe hepatotoxic reactions. Microsomal oxidation inhibitors reduce the risk of hepatotoxicity.

Antacids and cholestyramine reduce the absorption of ibuprofen. Caffeine enhances the analgesic effect of ibuprofen. Cefamandol, cefoperazone, cefotetan, valproic acid increase the incidence of hypoprothrombinemia.

Myelotoxic drugs increase the manifestations of ibuprofen hematotoxicity. Cyclosporine and gold preparations increase the effect of ibuprofen on the synthesis of PG in the kidneys, which is manifested by an increase in nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects. Drugs that block tubular secretion reduce excretion and increase the plasma concentration of ibuprofen.

Ibuprofen reduces the effect of antihypertensive drugs (including CCBs and ACE inhibitors), the natriuretic and diuretic activity of furosemide and hydrochlorothiazide, and the effectiveness of uricosuric drugs. Enhances the side effects of mineralocorticoids, glucocorticoids, estrogens, ethanol. Enhances the effect of oral hypoglycemic drugs and insulin. Increases the concentration in the blood of digoxin, lithium preparations and methotrexate. Ibuprofen may reduce the clearance of aminoglycosides (with simultaneous administration, the risk of nephrotoxicity and ototoxicity may increase).

Ibuprofen for intravenous administration should not be mixed with other drugs.

Precautions while taking Nurofen

Treatment with ibuprofen should be at the lowest effective dose, for the shortest possible duration. During long-term treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver and kidneys.

Given the possibility of developing NSAID gastropathy, it is prescribed with caution to the elderly, with a history of gastric ulcers and other gastrointestinal diseases, gastrointestinal bleeding, with simultaneous therapy with glucocorticoids, other NSAIDs and for long-term therapy. When symptoms of gastropathy appear, careful monitoring is indicated (including esophagogastroduodenoscopy, a blood test to determine hemoglobin, hematocrit, fecal occult blood test). To prevent the development of NSAID gastropathy, it is recommended to combine it with PGE preparations (misoprostol).

It is prescribed with caution to patients with impaired liver and kidney function (regular monitoring of the level of bilirubin, transaminases, creatinine, kidney concentration is required), arterial hypertension and chronic heart failure (daily monitoring of diuresis, body weight, blood pressure). If visual impairment occurs, the dose should be reduced or the drug should be discontinued.

Storage conditions for Nurofen

List B.: In a dry place, at a temperature not exceeding 25 ° C.

Nurofen expiration date

Belonging of the drug Nurofen to the ATX-classification:

M Musculoskeletal system

M01 Anti-inflammatory and antirheumatic drugs

M01A Non-steroidal anti-inflammatory drugs

M01AE Propionic acid derivatives

Nurofen is an anti-inflammatory, antipyretic, analgesic medicine, not hormonal. Express help for pain, migraine and high fever. The basis of the action of Nurofen is a substance from the group of propionic acid derivatives.

Once in the human body, ibuprofen fights the inflammatory process, inhibiting the mechanism of the appearance of substances that provoke the development of inflammation. Due to this, the level of inflammation decreases, the temperature decreases, pain decreases.

Ibuprofen activates the production of interferon in the body, a substance that is involved in the creation and strengthening of immunity. This quality of the active substance allows Nurofen to be classified as an antiviral drug.

The main action of the drug:

1. brings down the temperature;
2. removes or weakens the inflammatory process;
3. takes away the pain.

Nurofen: instructions for use of tablets (official)

Description of the forms of release and composition of the drug

1. Nurofen tablets in a sweet shell, including effervescent tablets
2. Express capsules for oral use
3. Candles / suppositories Nurofen for rectal use
4. Nurofen Gel
5. Nurofen syrup / suspension (Nurofen for children has a fruity taste)

Composition of Nurofen tablets

Each tablet of the drug contains 200 mg of active ingredient. Also, the composition of the tablets includes additional components. The tablets are in a blister. Blisters are made containing 6 or 12 Nurofen tablets.

Effervescent tablets also contain 200 mg of active ingredient. The composition of the tablet includes other components. The drug is available in tubes containing 10 effervescent tablets.

The price of Nurofen in tablets is from 104 rubles.

Suspension (syrup) Nurofen for children

It is presented as follows: 5 ml of the drug contains 100 mg of the active substance plus additional components. The package contains a dispenser. The vials are provided with a special mechanism that protects the drug from uncontrolled use by young children.

The price of Nurofen children's syrup is from 136 rubles. 100 ml. The price for children's syrup with a volume of 150 ml is 198 rubles.

Tablets and suspension are intended for oral use.

The body of a child has significant differences from the body of an adult. And what works for parents doesn't always work for children. Before treating your child, it would be right to go to the doctor for an appointment or call him at home.

Children do not always take pills with enthusiasm. Therefore, the developers of Nurofen foresaw this moment and offered the children's public a drug in the form of a suspension for oral administration and suppositories (capsules) for rectal use.

Nurofen capsules

Candles are intended for rectal use. 1 rectal suppository contains 60 mg of active ingredient plus solid fat for ease of use. Candles are packed in blisters. There are 5 candles in 1 blister. 1 package of the drug contains 2 blisters. The price for children's Nurofen in capsules (candles) is from 203 rubles. You can buy 1 blister with capsules.

Gel

Nurofen gel is used for external use. Contains 5% active ingredient. Produced in tubes of 30, 50 or 100 g. The price of the gel starts from 100 rubles.

Gel use

This dosage form of Nurofen is used for the following diagnoses and symptoms:

1. inflammation and swelling of the joints;
2. neuralgia;
3. muscle pain;
4. back pain;
5. pain after sports training, sprains, injuries and sports-related injuries.

Squeeze out from 4 to 10 cm of the gel and rub it over the surface of the skin with soft smoothing movements of the palm. You can repeat the procedure 1 time in 4 hours. How to use Nurofen suppositories for children?

Candles are very convenient to use in cases where the child categorically refuses to take medicine or has acetone, accompanied by nausea or vomiting.

Candles are prescribed rectally for children from 3 months to 2 years old with:

• high body temperature that accompanies colds and flu, as well as any other childhood diseases;
• fever after vaccination;
• pains (head, ear, tooth, throat, muscle, joints, neuralgia, bruises, sprains, punctures and fractures).

Candles are prescribed as follows:

Within 24 hours, the amount of medication taken should not exceed more than 30 ml per kilogram of body weight.

Depending on the number of years of the child, suppositories are prescribed as follows:

From 3 to 9 months: 1 suppository rectally (60 mg). If necessary, you can repeat after 6-8 hours, but no more than three times a day. The daily dose should not exceed 180 mg.

From 9 months up to 2 years: 1 suppository (60 mg). If necessary, you can repeat after 6 hours, but no more than four times a day. The daily intake of the medicinal substance should not exceed 240 mg.

In case of fever, complaints of pain, inflammatory processes, one should not self-medicate. You should definitely consult a doctor.

Nurofen syrup for children

The convenience of this medicine is that it is tasty. After all, many children refuse to drink bitter tablets; for babies, they have to be diluted with tea or compote. And a suspension with raspberry or orange flavor will appeal to them.

Instructions for use Nurofen children's syrup recommends it for the treatment of children from 6 months of age. But it is possible to use it at an earlier age, but only the doctor should decide.

Suspension is prescribed for:

• heat;
• teething;
• colds;
• otitis;
• all kinds of pain (muscle, headache, neuralgia, migraine).

Nurofen is prescribed depending on the age and weight of the child.

The amount of medication taken per day for each kilogram of the child's weight should not be more than 30 ml.

According to the number of years of the child, the suspension is prescribed as follows:

• From 3 months to six months: 2.5 ml (50 mg) of the drug. If necessary, it can be repeated after 8 hours. No more than three times a day.
• From six months to a year: 2.5 ml (50 mg) of the drug. If necessary, repeat after 6 hours. No more than four times a day.
• From one year to 3 years: 5 ml (100 mg) of the drug. If necessary, it can be repeated after 8 hours. No more than three times a day (15 ml).
• From 4 to 6 years - 5-7 ml (150 mg) of the drug. If necessary, it can be repeated after 8 hours. No more than three times a day (20 ml).
• From 7 to 9 years - 10 ml (200 mg) of the drug. If necessary, it can be repeated after 8 hours. No more than three times a day (30 ml).
• From 10 to 12 years - 15 ml (300 mg) of the drug. If necessary, it can be repeated after 8 hours. No more than three times a day (45 ml).

The suspension does not contain dyes and flavors, so it can be prescribed to children with diabetes.

General characteristics of the drug

Since the medicine is presented in several forms, it is worth designating separately each category of its use.

1. ARI, SARS, flu, with fever, pain;
2. pain in the gums and teeth;
3. lower back pain;
4. headache;
5. with migraine;
6. joint and muscle pain and inflammation, bruises, injuries, fractures;
7. rheumatic pains;
8. neuralgia.

The maximum daily dosage can be 6 tablets. Children over 12 years old and adults are recommended to take 1-2 tablets 3-4 times a day.

Children under 12 years of age can take no more than 4 tablets per day, 1 tablet per dose.

You can take the drug for 2-3 days, then, if the condition has not improved, you need to find a more effective remedy. To do this, you should consult a doctor.

Indications for taking Nurofen Express

1. inflammation of the upper respiratory tract;
2. ARI, SARS, influenza, other viral diseases with fever, pain;
3. pain in the gums and teeth;
4. lower back pain;
5. headache (you can take Nurofen for migraine);
6. pain and inflammation in the joints and muscles, injuries;
7. rheumatic pains;
8. neuralgia.

Daily dose of Express means for adults: from 1200-2400 mg per day for 3-4 doses. Dosage should be discussed with your doctor. It is recommended to take the medicine after meals.

Overdose, side effects and contraindications

Excessive use of the drug can cause the following symptoms:

1. there are pain in the abdomen;
2. may feel sick to the point of vomiting;
3. mood worsens, you want to sleep, feeling lethargic and lethargic;
4. noise in ears;
5. headaches;
6. lowering blood pressure;
7. violation of the functions of the genitourinary system up to the syndrome of renal failure;
8. violation of cardiac activity.

An overdose of the drug can lead to a state of coma and respiratory arrest.

Side effect

Before using the drug, you should consult with your doctor. Despite the fact that Nurofen, in most cases, is perceived well, in some cases it can have a negative effect on the functioning of the kidneys, heart, gastrointestinal tract, respiratory system, and cause allergic reactions.

The drug can provoke a change in the microflora of the stomach and duodenum, cause formation in these organs.

After treatment with the drug, nausea, urge to vomit, bloating may appear.

You should be careful with the use of drugs for kidney disease, as it can cause functional kidney failure, inflammation in the kidneys and bladder.

Contraindications for use

The presence of diseases of the gastrointestinal tract, such as ulcerative process in the stomach and duodenum 12, ulcerative colitis.

Hypertension.

Depression of hematopoiesis or inhibition of the growth of new blood cells, diseases of the circulatory and hematopoietic system, for example, hemorrhagic diathesis.

Diseases of the optic nerve.

Do not apply the gel on the skin, which has wounds, ulcers, lesions, rashes.

The appointment must be made by a doctor. Self-medication can cause a deterioration in the health of not only the mother, but also her baby.

Does the drug interact with other drugs?

When treating hypertension, taking diuretics, taking Nurofen can lead to a decrease in the effectiveness of such treatment.

Simultaneous reception of Nurofen increases the risk of hemorrhages, bleeding and other complications.
The use of alcoholic beverages during treatment with Nurofen can lead to the development of diseases of the stomach and intestines or seriously complicate them.

Health care does not tolerate negligence and amateurism. Self-medication often causes complications of the process and the appearance of additional problems. Sometimes this attitude to one's health can cost a person a life. Pain, inflammation, fever - a serious way to go to the hospital or call a doctor at home.

Video: Antipyretics (school of Dr. Komarovsky)

If you need a non-steroidal, broad-spectrum anti-inflammatory drug, give preference to Nurofen. Due to the various forms of release, it can be used even for children from 3 months of age. Nurofen relieves the main symptoms of a cold, eliminates pain of any etiology, and stabilizes body temperature.

At a room temperature not exceeding 25 degrees Celsius, its shelf life is 3 years. At the same time, remember that rectal suppositories are stored at a temperature not higher than 15 degrees Celsius.

Release form

Nurofen refers to non-steroidal, anti-inflammatory drugs. The drug will help normalize body temperature, eliminate pain during the eruption of milk teeth in an infant, and relieve pain of various origins. The medicine is produced in the following dosage forms:

1. Nurofen tablets are coated. It is prescribed for children with a weight of 20 kilograms and adult patients. In the contour cell is from 6 to 24 pieces. These flu pills are often prescribed by doctors.

2. Effervescent (soluble) tablets Nurofen. There are 10 pieces in the contour cell. Approved for use by adults and children from 12 years of age.

3. Nurofen Express, capsules, 12 pieces in a contour cell. It is prescribed for adult patients and children over 12 years of age.

4. Nurofen Ultracap. In a contour cell on 4 or 10 capsules. It is prescribed for adults and children from 12 years of age.

5. Nurofen Forte tablets. In the contour cell can be from 6 to 24 pieces. It is prescribed for adults and children from 12 years of age.

6. Nurofen Plus tablets are film-coated. Approved for use by persons over 12 years of age. There are 12 pieces in the contour cell.

7. Nurofen suspension for children is sold in plastic bottles of 50, 100 and 150 ml, complete with a measuring syringe or spoon. It is prescribed for children from 3 months of age, whose body weight is not less than five kilograms.

8. Nurofen rectal suppositories for children. Are issued in a contour cell on 12 pieces. Approved for use by children weighing more than six kilograms.

9. Nurofen gel 5%, in tubes of 20, 30, 50 and 100 grams. Approved for use by persons over 12 years of age.

Pharmacological properties

The active ingredient in Nurofen is ibuprofen, which is a non-steroidal anti-inflammatory compound. It has an anesthetic, antipyretic and anti-inflammatory effect. Ibuprofen blocks the formation of prostaglandins. It has been proven that the drug induces the body to produce interferon, as a result of which the protective functions of the body increase. The pharmacological agent is rapidly absorbed in the gastrointestinal tract and binds to blood proteins. The highest content of ibuprofen in the patient's blood is observed 30–45 minutes after application. The drug is excreted by the intestines and kidneys.

Indications for use

Nurofen helps to normalize body temperature. Effective in such forms of pain:

• rheumatic;
• head;
• dental;
• muscular;
• menstrual.

The gel is effective for damage and sprains, arthritis, sports injuries.

Children's Nurofen in the form of a suspension should be taken for post-immunization fever, otitis media, teething, sore throat.

The use of Nurofen and its dosage depends on the form of release and the age category of the patient. Without a doctor's prescription, you should not use the drug for more than five days in a row. It is forbidden to exceed the recommended dosage. Before use, shake the children's syrup well and draw the required amount of suspension into a measuring syringe. The interval between doses is 6 hours.

Nurofen, basic instructions for use:

1. Nurofen dosages for children. The dose required for use is determined based on the body weight of the child. One kilogram will require 5-10 mg of ibuprofen, taken if necessary 3 or 4 times a day, but not more than 30 mg / kg.

1.1. Rectal suppositories. From temperature and pain:

• infants from 3–9 months and weighing 5 to 8 kilograms, one suppository (60 mg), the interval of use is 6–8 hours, but not more than 180 mg per day;
• children from 9 months to 2 years old and weighing from 8 to 12.5 kilograms, one suppository (60 mg) 4 times a day, with an interval of 6 hours, not more than 240 mg per day.

With post-immunization fever, children under one year old - one candle, if necessary, repeat no earlier than 6 hours later, no more than 2 pieces per day.

1.2. Suspension. For fever and pain:

• infants from 6 to 12 months, 2.5 ml;
• children from the first year to three years, 5 ml of syrup;
• children from four to six years old, 7.5 ml;
• children from seven to nine years old, 10 ml;
• children from ten to twelve years old, 15 ml.

After vaccination, children under one year old can, if necessary, be given a single dose of 2.5 ml of syrup. Children from one year - 2.5 ml, if necessary, repeat no earlier than six hours later, no more than 5 ml per day.

2. Dosage of Nurofen tablets for adults and children over 12 years of age. A single dose should be no more than 200 mg. Take if necessary 3-4 times a day, without chewing, drinking water. Adults can increase the dose to 400 mg once. Adolescents from 12 to 17 years old are prohibited from taking more than 1000 mg of Nurofen per day, adults no more than 1200 mg.

3. Nurofen ointment can be used from the age of 12. Squeeze out a small amount of gel and rub into the skin until completely absorbed. The next application is only after four hours. It is not recommended to use for more than two weeks.

Contraindications, overdose and side effects

It is necessary to abandon the use of tablets and suspensions when:

• ulcer, gastritis, inflammation of the duodenum;
• pregnancy;
• high blood pressure;
• diseases of the kidneys and liver;
• individual intolerance, one of the components that make up the drug.

Adverse reactions at observance of a dosage meet extremely seldom. Sometimes a person's blood pressure rises, shortness of breath, dizziness and an allergic rash appear. Overdose is manifested by tinnitus, nausea, vomiting, diarrhea and headache.

During pregnancy and lactation

During pregnancy, Nurofen can be used in the first and second trimester. In the third trimester, its use is dangerous for the fetus. Also, a small concentration of ibuprofen has been found in breast milk, the risk of negative effects on the child is unlikely.

Analogues

There are a huge number of analogues of Nurofen. Among them are Ibuprofen (the cheapest analogue), Imet, Cefekon, Advil, Bofen, Ibalgin.

Efficiency and reviews

Nurofen has long established itself as an effective remedy that can cope with any kind of pain, normalize body temperature during flu and colds. Its serious advantage is a large selection of dosage forms that will allow you to choose a medication for each age category.

Inga, Sevastopol: “My child has a hard time with all vaccinations. He has a fever and complains of a headache. Repeatedly used Nurofen syrup. Half an hour later, Serezha is already jumping and playing, forgetting about his headache and temperature.

This abstract is abbreviated and introductory.