Panangin instructions for use in ampoules intravenously. How is the solution used?

The drug Panangin is an important source of electrolytes (magnesium, potassium ions) for the activity of the main organ. In addition, it expresses the impact on metabolic processes. A remedy is produced, both in tablets, and you can find Panangin in ampoules, the instructions for use of which prescribe for which diseases the medication is indicated, how it is used.

One of the forms of release is a solution for internal use; it is also an injection ampoules.

The medicine contains components that are important to the body. These are substances such as potassium and magnesium. With a lack of these substances in the body, a large number of problems arise in the activity of the heart.

In the substance potassium, the main purpose is to maintain the membrane capacity of myocytes, neurons, and tissue structures of the myocardium. When the balance between the extracellular and intracellular presence of potassium is disturbed, a decrease in contractions of the heart muscle occurs, and then arrhythmia and tachycardia occur.

The substance magnesium refers to the main thing in most of the farm effects, the most active metabolism, the integrity of nucleic acids. It affects the activity of the main organ, favoring a decrease in the tension of contractions, reduces the frequency of contractions of the function of the main organ and the need for myocardial oxygen. Thanks to the magnesium substance, a pronounced anti-ischemic effect on the myocardium occurs.

Together, these 2 components present in the solution reduce the toxicity of cardiac glycosides without affecting their inotropic activity.

In addition, the combination of components indicates that a lack of one of them leads to a deficiency of the other and leads to the manifestation of the following diseases.

1. Hypertension.
2. Atherosclerosis.
3. Arrhythmia.

The solution for intravenous injection has a colorless tint or a slightly greenish, transparent color.

The composition of the solution:

• potassium asparanginate - hemihydrate;
• magnesium aspartate - tetrahydrate.

The other ingredient is water.

Indications for use

The medicine in the form of a solution is shown:

• as a complex cure for heart failure, acute infarction, with a change in heart rate (ventricular arrhythmia, arrhythmias provoked by an overdose of glycosides), which are determined by electrolyte changes;
• with hypokalemia, when the potassium level in the circulatory system is reduced;
• with rhythm changes that are associated with digitalis drug intoxication;
• with paroxysms of atrial fibrillation;
• to improve the tolerance of cardiac glycosides;
• make up for the lack of magnesium and potassium, if their intake is reduced in food.

Panangin also treats coronary inferiority, which indicates a discrepancy between the cardiac need for oxygen and its intake.

How is the solution used?

Panangin is prescribed into the vein, a slow introduction of the solution is required, 20 drops per minute are dripped. If necessary, the drug can be administered again after 6 hours.

To prepare a medicine for an intravenous dropper, take 1 ampoule and dilute them with 5% glucose (50-100 ml).

The drug can be used for combined treatment.

Use of the solution during childbearing and breastfeeding

There is no information on the negative impact of the drug in the form of a solution for intravenous infusion during childbearing and breastfeeding.

Use for changes in kidney function

In acute and chronic form of renal inferiority, oliguria, anuria.

Important Information

It is necessary to prescribe panangin with extreme caution to patients with an increased risk of hyperkalemia. In this case, you will need to constantly monitor the level of potassium ions in the blood.

Before using the medicine, the patient should consult a doctor.

If you quickly inject the drug into the vein, hyperemia of the skin may develop.

Panangin does not affect the ability to drive vehicles, and to do work that requires concentrated concentration and an instant psychomotor reflex.

Panangin contraindication

The drug is not administered in the following diseases and conditions of the patient:

• renal inferiority in acute and chronic form;
• hyperkalemia;
• hypermagnesemia;
• Addison's disease;
• cardiogenic shock;
• dehydration;
• severe myasthenia gravis;
• inferiority of the adrenal cortex;
• minors;
• lactation period;
• during breastfeeding;
• high sensitivity to the components present in the composition.

With extreme caution, the solution is administered in case of:

• with changes in the functioning of the liver;
• metabolic acidosis;
• threat of puffiness;
• changes in the functioning of the kidneys, when it is not possible to regularly monitor the content of magnesium in the blood;
• hypophosphatemia;
• urolithic diathesis, which is associated with a change in the metabolism of magnesium, calcium, ammonium phosphate.

Side effects of panangin

When the solution is abruptly administered, signs of hyperkalemia may develop.

1. The patient gets tired quickly.
2. Myasthenia.
3. Paresthesia.
4. Confused consciousness.
5. The rhythm of the heart is disturbed (tachycardia, bradycardia).

If the patient complains of dizziness, reduce the dose.

If signs of hypermagnesemia occur, the following may occur:

• neuromuscular excitability will decrease;
• there will be reflexes to vomiting;
• vomit;
• lethargy;
• blood pressure will decrease.

Phlebitis may also develop, the amount of extrasysitol will increase. With a rapid increase in the presence of magnesium ions in the circulatory system, the following occurs:

• suppression of tendon reflexes;
• paralysis of the respiratory system;
• a person has a coma.

For treatment, the drug is canceled, symptomatic therapy is carried out, calcium chloride is injected into the vein. When necessary, carry out the procedure of hemodialysis, peritoneal dialysis.

Conjugation of Panangin with other drugs

If used simultaneously with potassium-sparing diuretics - triamterene, spironolactone, as well as beta-andrenoblockers, cyclosporine, heparin, inhibitors, ACE, NVPS, there is an increase in the risk of hyperkalemia, arrhythmia, asystole may occur.

When taking potassium along with GCS, hypokalemia goes away. Under the influence of potassium, one can notice a decrease in the unjustified effects of cardiac glycosides. Panangin is also able to enhance the negative dromo and bathmotropic effect of antiarrhythmic drugs.

Since potassium ions are present in the preparation, when using the product together:

• with ACE inhibitors;
• beta - andrenoblockers;
• cyclosporine;
• heparin;
• NSAIDs;
• hyperkalemia may develop, up to the occurrence of extrasystole.

Magnesium medicines reduce the effect of:

• neomycin;
• polymyxin;
• tetracycline;
• streptomycin.

Calcium supplements can reduce the effects of magnesium medications. Thanks to anesthetics, the inhibitory effect of magnesium on the nervous system becomes stronger.

Using Panangin with atracurium, dexamethonium, suxamethonium, an increase in the neuromuscular environment can be observed. If taken with calcitriol, the magnesium level in the circulatory system will increase.

Medicines that have an astringent and enveloping effect can reduce the absorption of the drug in the gastrointestinal tract. It is required to adhere to a 3-hour interval between the use of the medicine with the means listed above.

The drug for internal use is compatible with a solution of cardiac glycosides, which help to improve their tolerance, reduce the unpleasant effects of cardiac glycosides.

In order to purchase panangin in the form of a solution, you will need a prescription from a doctor.

Registration number: P N013093/01

Tradename: Panangin

International nonproprietary or grouping name: Potassium Aspartate + Magnesium Aspartate &

Dosage form: concentrate for solution for infusion.

Composition per ampoule:

Active substances: Potassium aspartate (in the form of potassium aspartate hemihydrate) 452 mg (corresponding to 103.3 mg of potassium ions), magnesium aspartate (in the form of magnesium aspartate tetrahydrate) 400 mg (corresponding to 33.7 mg of magnesium ions);
Excipients: water for injection - up to 10 ml.

Description: Colorless or slightly greenish, clear solution.

Pharmacotherapeutic group: potassium and magnesium preparation.

ATX code: A12CX

Pharmacological properties

Pharmacodynamics
Panangin is a source of important electrolytes: potassium and magnesium ions. One of the most important functions of potassium ions is to maintain the membrane potential of neurons, myocytes, and excitable structures of myocardial tissue. Imbalance between intracellular and extracellular potassium leads to a decrease in cardiac contractility, arrhythmias, tachycardia and increased toxicity of cardiac glycosides.
Magnesium is an important cofactor in over 300 enzymatic reactions, including energy metabolism and protein and nucleic acid synthesis. In addition, magnesium plays an important role in the work of the heart: it improves contractility and heart rate, leading to a decrease in myocardial oxygen demand. A decrease in the contractility of smooth myocytes of arterioles leads to vasodilation, including coronary vessels, and to an increase in coronary blood flow. Magnesium has an anti-ischemic effect on myocardial tissue.
The combination of potassium and magnesium ions in one preparation is based on the fact that potassium deficiency in the body is often accompanied by magnesium deficiency and requires simultaneous correction of the levels of both ions. Further, with the simultaneous correction of the levels of these electrolytes, an additive effect is observed (low levels of potassium and / or magnesium have a proarrhythmic effect), in addition, potassium and magnesium reduce the toxicity of cardiac glycosides without affecting the positive inotropic effect of the latter.
Pharmacokinetics
There is no data.

Indications

To eliminate the deficiency of potassium and magnesium as an aid in various manifestations of coronary heart disease, including acute myocardial infarction; chronic heart failure; cardiac arrhythmias (including arrhythmias caused by an overdose of cardiac glycosides).

Contraindications

Hypersensitivity to the drug, acute and chronic renal failure; Addison's disease; atrioventricular block II, III degree; cardiogenic shock (blood pressure Precautions

Atrioventricular blockade of the 1st degree, severe liver dysfunction; metabolic acidosis; the risk of edema; impaired renal function in the event that regular monitoring of the magnesium content in the blood serum is impossible (danger of cumulation, toxic magnesium content); cardiogenic shock (systolic blood pressure less than 90 mm Hg); hypophosphatemia; urolithic diathesis associated with a violation of the metabolism of calcium, magnesium and ammonium phosphate.

Pregnancy and lactation

There are no data on the harmful effects of the drug during pregnancy.

Dosage and administration

For intravenous administration only.
The contents of 1-2 ampoules should be diluted in 50-100 ml of 5% dextrose (glucose) solution and administered intravenously as a slow drip infusion (20 drops per minute). If necessary, you can repeat the dose after 4-6 hours.
The drug is suitable for combination therapy.

Side effect

With rapid intravenous administration, symptoms of hyperkalemia may develop (fatigue, myasthenia gravis, paresthesia, confusion, heart rhythm disturbance (bradycardia, atrioventricular block, arrhythmias, cardiac arrest) and hypermagnesemia (decrease in neuromuscular excitability, urge to vomit, vomiting, lethargy, lowering blood pressure It is also possible to develop phlebitis, atrioventricular blockade and a paradoxical reaction (an increase in the number of extrasystoles).

Overdose

To date, cases of overdose have not been described. In case of an overdose, the risk of symptoms of hyperkalemia and hypermagnesemia increases.
Symptoms of hyperkalemia: fatigue, myasthenia gravis, paresthesia, confusion, heart rhythm disturbance (bradycardia, atrioventricular block, arrhythmias, cardiac arrest).
Symptoms of hypermagnesemia: a drop in neuromuscular excitability, retching, vomiting, lethargy, a decrease in blood pressure (BP). With a sharp increase in the content of magnesium ions in the blood - inhibition of deep tendon reflexes, respiratory paralysis, coma.
Treatment: In case of symptoms of an overdose, treatment with Panangin should be discontinued and symptomatic therapy should be carried out (intravenous administration of calcium chloride at a dose of 100 mg / min, if necessary, hemodialysis should be prescribed).

Interaction with other drugs

Enhances the negative dromo- and batmotropic effect of antiarrhythmic drugs.
Eliminates hypokalemia caused by glucocorticoids.
Due to the magnesium content, it reduces the effect of neomycin, polymyxin B, tetracycline and streptomycin. Cyclosporine, potassium-sparing diuretics, heparin, ACE inhibitors may increase the risk of hyperkalemia.
Anesthetics enhance the inhibitory effect of magnesium on the central nervous system.
May enhance neuromuscular blockade caused by depolarizing muscle relaxants (atracurium besilate, decamethonium bromide, suxamethonium (chloride, bromide, iodide)).
Calcitriol increases the concentration of magnesium in the blood plasma, calcium preparations reduce the effect of magnesium.
Beta-blockers, non-steroidal anti-inflammatory drugs increase the risk of developing hyperkalemia up to the development of arrhythmias and asystole.
Pharmaceutically compatible with solutions of cardiac glycosides (improves their tolerance, reduces the undesirable effects of cardiac glycosides).

special instructions

With rapid administration, the development of hyperemia of the skin is possible.
Special care should be taken in the presence of diseases accompanied by hyperkalemia. In these cases, it is recommended to control the content of potassium ions in the blood.

The effect of the drug on the ability to drive vehicles and mechanisms

Not studied.

Release form

Concentrate for solution for infusion, 45.2 mg/ml +40 mg/ml.
10 ml of the drug in a colorless glass ampoule (hydrolytic class 1), 5 ampoules in a plastic tray. 1 plastic pallet in a cardboard box with instructions for medical use.

Storage conditions

Store at a temperature of 15 to 30 °C.
Keep out of the reach of children!

Shelf life

3 years.
Should not be used after the expiration date.

Holiday conditions

On prescription.

Manufacturer:

OJSC "Gedeon Richter"
1103 Budapest, st. Dömröi, 19-21, Hungary

Consumer claims should be sent to:

Moscow Representative Office of JSC "Gedeon Richter"
119049 Moscow, 4th Dobryninsky lane, house 8.

"Panangin" in ampoules is a drug that can affect the metabolism in tissues and contains magnesium and potassium. The drug is recommended for patients in the treatment of pathologies in the cardiovascular system, accompanied by impaired metabolism in the myocardium. The drug is contraindicated in childhood, during pregnancy, in patients suffering from hypermagnesemia (high levels of magnesium in the blood) and hyperkalemia (high levels of potassium in the blood).

In the article, we will consider the instructions for use for Panangin and the reviews of cardiologists.

Pharmacological forms

The manufacturer "Panangin" is produced in two pharmacological forms: tablets intended for oral administration, and a solution that can be administered intravenously as a stream or drip. Tableted "Panangin" has a biconvex rounded shape, has a former color and a shiny surface. The drug is packaged in 50 tablets in polypropylene bottles.

"Panangin" in ampoules is intended for intravenous administration, it is a clear, colorless, sterile liquid without any impurities. It is packaged in 10 ml ampoules, which are packed in 5 pieces in a cardboard box. Before jet intravenous administration, the contents of the ampoule should be diluted with 50 ml of glucose (5%). If drip administration is intended, then the drug should be diluted with saline in an amount of 200 ml.

Composition, description

The main active ingredients of the drug are potassium aspartate and magnesium aspartate. Each tablet contains 158 and 140 mg of substances, respectively. Each ampoule of "Panangin" contains 452 mg and 400 mg of substances, respectively. Potassium and magnesium ions are important intracellular cations. Along with sodium and calcium, they take part in the activity of various enzymes that regulate tissue metabolic processes, including those in myocardial tissues. The active components of the drug have a positive effect on the process of assimilation of oxygen, nutrients, on the ability of the heart to contract.

As additional components in the composition of the tablets, potato starch, corn starch, magnesium stearate, povidone, silicon dioxide were used. The auxiliary substance in the composition of the solution is injection water. The additional ingredients contained in the preparation are necessary to improve the absorption of active ingredients, to create the most convenient pharmacological form.

Pharmacological group

"Panangin" in ampoules is included in a group of drugs with a predominant effect on tissue metabolism. According to its pharmacological group, it belongs to mineral substances containing potassium and magnesium. The drug is able to influence the metabolic processes in myocardial tissues, prevent the death of cardiomyocytes, the development of hypoxic phenomena. Against the background of the use of "Panangin", the contractility of the heart and the activity of the heart and vascular system as a whole are normalized.

What is the effect of "Panangin"?

Pharmacodynamics, pharmacokinetics

Magnesium and potassium ions are important cations that affect the function of enzymes that can regulate tissue metabolism. Aspartate, which is an endogenous substance that forms strong chemical compounds with various elements, transports cations through the membranes into the cell. The active substances of the drug enter the cell in the form of complex compounds. Their function depends on the concentration of calcium and sodium in the intercellular and cellular space. Cations are able to regulate the process of assimilation of nutrients and oxygen by the myocardium, as well as myocardial contractility. A deficiency of potassium and magnesium in the body can provoke pathological changes in the cardiovascular system, for example, arterial hypertension, arrhythmia, sclerosis of the myocardium, coronary arteries.

The pharmacokinetics of Panangin has not been studied by the manufacturer. It is reliably known that the absorption of active components in the gastrointestinal tract is quite high. If the drug is administered intravenously, then the accumulation of substances occurs in the myocardium, while developing the maximum therapeutic effect. Potassium and magnesium aspartate is excreted from the body mainly through the kidneys.

So, what is Panangin for?

Indications for use

1. Substitution therapy for deficiency of magnesium and potassium ions of various nature.
2. Chronic form of heart failure.
3. Conditions after a heart attack.
4. Cardiac ischemia due to circulatory failure in the coronary arteries.
5. Ventricular extrasystole.
6. Atrial fibrillation type arrhythmia.
7. Cardiac arrhythmias caused by intoxication with glycosides, which are part of the digitalis group.
8. Heart rhythm disturbances that develop against the background of changes in electrolyte balance, associated primarily with hypokalemia (lack of potassium ions in the blood).

When conducting long-term therapy using Panangin, it is important to periodically monitor the concentration of potassium and magnesium ions in the blood.

It is contraindicated in pediatric patients.

During pregnancy, the use of the drug is allowed if there are individual indications starting from the second trimester. The use of the drug in the first trimester can lead to toxic poisoning of the fetus.

If there is a need to use the medication in the lactation period, it is recommended to temporarily suspend feeding and transfer the child to artificial mixtures.

Contraindications for use

Before starting the use of Panangin in injections, it is important to consult a doctor and take into account the existing contraindications, including:

1. Violations of the conduction of impulses in the AV node.
2. Severe forms of hepatic, renal failure.
3. cardiogenic shock,
4. Addison's disease.
5. metabolic acidosis.
6. hemolytic anemia.
7. Dehydration of the body against the background of extensive burns, overheating, diarrhea, repeated vomiting.
8. Impaired amino acid metabolism.
9. Hypermagnesemia (increased concentration of magnesium in the blood), hyperkalemia (increased concentration of potassium).
10. Individual susceptibility to any of the components that make up the medicinal product.

Let us consider in more detail the dosages of "Panangin".

Medication use

The tablet preparation is recommended to be used three times a day in an amount of up to 2 tablets. If the patient has severe forms of the disease, it is permissible to increase the single dosage to 3 tablets. Maintenance therapy involves the use of the drug for 3 weeks three times a day, 1 tablet. The drug should be taken after eating, as gastric juice has a destructive effect on the active components of the drug. The tablets should be swallowed whole with a sufficient amount of liquid.

Before jet intravenous administration, the ampoule is diluted in 50 ml of glucose (5%). Before installing a dropper with Panangin, the drug is diluted with 200 ml of saline. The introduction should be done slowly. The duration of the therapeutic course is determined by the doctor, taking into account the severity of the pathological phenomenon.

In the treatment of pregnant women, Panangin is prescribed according to standard schemes, taking into account the risk to the child and the therapeutic need for the mother. In the lactation period, the drug is contraindicated.

Negative impacts

Against the background of the use of Panangin, the following negative effects may develop: dizziness, abdominal pain, nausea. As a rule, side effects occur rarely, and their clinical manifestations disappear without any treatment within a few days.

What is the compatibility of "Panangin"?

Interaction with other drugs

The parallel use of the drug with potassium-sparing diuretics and ACE inhibitors can provoke the development of hyperkalemia, which increases the likelihood of severe arrhythmias and subsequent cardiac arrest.

Rapid intravenous administration of the drug causes dizziness, nausea, redness of the face. To prevent these conditions, it is recommended to administer the medication at a slow pace.

It is important to exercise caution when prescribing the drug to patients suffering from extensive tissue damage, extensive burns, myasthenia gravis, since the risk of hyperkalemia is significant.

Is the action of "Panangin" always safe?

Overdose

In case of an overdose, the patient develops symptoms of hypermagnesemia and hyperkalemia: arrhythmia develops, sensitivity in the limbs is disturbed, diarrhea occurs, repeated vomiting, facial flushing, lethargy, hypotension, convulsions, respiratory depression, there is a possibility of cardiac arrest.

If signs of intoxication occur, you should immediately stop taking the drug, wash the patient's stomach, provide enterosorbents, prescribe peritoneal dialysis and hemodialysis.

Analogues of "Panangin"

If necessary, the medication can be replaced with one of the following drugs:

1. "Asparkam-L". It is a domestic analogue of Panangin, produced in injectable form. Prohibited for use by minors, pregnant women, in the lactation period.
2. "Potassium Magnesium". It is a dietary supplement that is not allowed to be taken during the lactation period, during pregnancy, under the age of 14 years.
3. "Potassium and magnesium aspartate". It is a drug of German origin. Produced in the form of a solution. Contraindications to its use are children's age, lactation period, pregnancy.
4. "Asparkam". It is a complete analogue of "Panangin". Pharmacological form of "Asparkam" - tablets. It is allowed to use with caution in the lactation period and during pregnancy.

"Asparkam" or "Panangin"?

It should be noted that "Asparkam" is a complete analogue of "Panangin", time-tested. Moreover, the cost of Asparkam is much lower than that of Panangin.

However, the main requirement for the drug is its effectiveness. Patients note that this figure is higher in Panangin.

Despite this, the doctor should determine which drug should be taken - "Asparkam" or "Panangin".

Price

The average cost of "Panangin" is 145 rubles per pack of solution, 140 rubles per pack of tablets. It depends on the region.

The drug Panangin is a source of magnesium and potassium ions - electrolytes that help maintain heart function. In addition, it has a pronounced effect on metabolic processes. The product is available in tablets and ampoules. In the register of medicinal products (RLS), the Latin name of the drug is Pananginum.

Panangin

Pharmacological features

In the ampoules of the drug Panangin there are vital substances for the body. With a lack of potassium and magnesium, a large number of ailments associated with cardiac activity can appear.

Potassium provides support for the membrane abilities of neurons, myocytes, myocardial tissue particles. If the balance between intracellular calcium and its content outside the cells is disturbed, the number of contractions of the heart muscle increases, followed by tachycardia and arrhythmia attacks.

Magnesium contained in the preparation activates metabolic processes, ensures the integrity of various cells and structures of the body. This substance has a positive effect on the work of the heart muscle, relaxing the myocardium, relieving tension, reducing the heart rate and the need for oxygen in the main organ. Magnesium provides reliable protection of the myocardium from ischemia.

Together, potassium and magnesium contained in panangin injection ampoules reduce the toxicity of drugs - cardiac glycosides, without reducing their inotropic activity. With a deficiency of one of these elements, the following diseases can develop:

• atherosclerotic disease;
• hypertension;
• Arrhythmia.

The solution for the introduction of liquid panangin has no color, in some cases its shade is slightly greenish. The composition of the drug is as follows:

• Potassium aspartate;
• Magnesium tetrahydrate;
• Water as a supplement.

Panangin solution: instructions for use and indications

A solution of Panangin should be dripped in such cases:

1. For the complex treatment of cardiac insufficiency, the acute stage of a heart attack, with left ventricular arrhythmia or rhythm disturbances associated with an overdose of glycoside substances;
2. With hypokalemia, if the content of potassium in the blood is lowered;
3. In case of heart rhythm failures associated with poisoning with digitalis-based drugs;
4. With atrial fibrillation paroxysms;
5. To improve the tolerance of glycosides;
6. To compensate for the lack of potassium and magnesium ions, if their amount in food is too low.

With the help of panangin in liquid form, coronary insufficiency can be treated, in which there is a big difference between the cardiac oxygen demand and its supply through the bloodstream.

What causes an electrolyte deficiency?

When the index of magnesium and potassium in the body is lowered, it causes various ailments. Metabolic changes develop in the heart muscle, blood pressure rises, plaques appear in the coronary arteries. Panangin makes it possible to replenish the missing amount of magnesium and potassium ions in the body. In the event of a violation of the natural balance between these two elements, the consequences may be as follows:

• Reduced myocardial contractility;
• Changes in the rhythm and frequency of the heartbeat;
• The toxic effect of drugs for the treatment of CHF - cardiac glycosides - increases.

Rupture of the heart is considered the most important cause of the complete incapacity of patients and their death. Given the statistics, in deceased patients, the amount of magnesium in the body was half that of healthy people. This element is able to prevent the development of ischemic heart attack, increase blood flow through the coronary arteries.

With a lack of potassium in the human body, dangerous arrhythmias may appear, the heart will function defectively, and the risk of stroke and heart attack will increase. So if you increase the amount of daily potassium intake by 40 percent, you can reduce the likelihood of developing these pathologies.

Panangin in ampoules will help to strengthen the heart, normalize metabolic functions, improve myocardial activity. Instructions for use indicate that thanks to this drug, premature diseases of the cardiovascular system, aging of the heart are effectively prevented, the likelihood of developing atherosclerotic diseases, hypertension and heart rhythm failures is reduced. A heart impulse will be carried out without hindrance, the walls of blood vessels will become stronger, become wear-resistant and elastic.

The active elements of panangin stop the spread of atherosclerotic plaques, provide a decrease in excessive blood viscosity, which prevents the formation of blood clots.

When is panangin needed?

Panangin is used for such diseases and pathologies:

1. heart attack;
2. Deficiency of potassium and magnesium;
3. Functional insufficiency of the heart;
4. Diarrhea;
5. Long-term vomiting or diarrhea, accompanied by a massive loss of electrolytes;
6. Paroxysmal tachycardia;
7. General poisoning;
8. Atrial fibrillation.

Attention! Panangin must be used necessarily when taking glucocorticosteroid drugs, laxatives and diuretics.

This medicine is used in open ductus ductus arteriosus, open foramen ovale and other small heart anomalies in infants, strengthening the child's myocardium. It is also prescribed in pediatric and neurological practice to relieve convulsions associated with a lack of potassium or magnesium ions.

Preparation and administration of the solution

The drug is prescribed for intravenous infusion. In this case, the drug should be administered slowly. The duration of the solution in the injection process is 20 minutes. If necessary, repeated parenteral administration of Panangin can be performed six hours after the first procedure so that there are no side effects from an overdose. Much less often, this medicine is administered intramuscularly. The course of treatment is 10 procedures.

For the preparation of a drug for a dropper, one ampoule of the drug is used, diluted with 5% glucose in a volume of up to 100 milliliters. You can also dilute the drug in saline with the addition of Riboxin.

Panangin can be used for complex therapy.

The use of the drug during lactation or pregnancy is allowed, only with great caution, since studies on the effects of panangin on the fetus have not been conducted.

If the patient has chronic kidney failure, anuria or oliguria, then the drug is not recommended.

Important information

It is necessary to pay special attention to the use of panangin in patients who have an increased risk of excess potassium in the body. In this case, you need to constantly monitor the content of potassium ions in the blood.

Regardless of the form of release, before using the medicine, a person should consult a cardiologist. If you inject the drug into a vein at a rapid pace, skin hyperemia may occur.

pharmacodynamics. Potassium and magnesium ions, as important intracellular cations, are involved in the work of a number of enzymes, in the process of binding macromolecules to subcellular elements, and in the mechanism of muscle contraction at the molecular level. The ratio of extra- and intracellular concentrations of potassium, calcium, sodium and magnesium ions affects the contractility of the myocardium. Aspartate as an endogenous substance is a carrier of potassium and magnesium ions; has a pronounced affinity for cells, its salts undergo dissociation only slightly. As a result, ions penetrate into the intracellular space in the form of complex compounds. Magnesium and potassium asparaginate improves the metabolism of cardiac muscles. Inadequate intake of potassium and magnesium in the body contributes to the development of hypertension, pathology of the coronary vessels of the sclerotic type, heart rhythm disturbances, and myocardial degeneration.

Pharmacokinetics. Has not been studied.

for additional therapy in chronic heart diseases (with heart failure, in the post-infarction period), cardiac arrhythmias, primarily ventricular arrhythmias.

Additional therapy in the treatment of digitalis preparations.

Panangin is prescribed exclusively in / in.

Adults are injected slowly intravenously in drops of 10-20 ml (the contents of the ampoule are diluted in 50-100 ml of 5% glucose solution). This dose can be repeated after 4-6 hours if necessary.

The drug is suitable for combination therapy.

The course of treatment is determined by the doctor.

hypersensitivity to the active substance or any of the excipients of the drug. OPN and HPN. Addison's disease. AV blockade of the III degree. Cardiogenic shock (BP<90 мм рт. ст.).

with rapid administration of the drug, symptoms of hyperkalemia / hypermagnesemia may occur.

rapid administration may cause flushing of the face.

Panangin as a preparation containing potassium and magnesium should be used with caution in patients with myasthenia gravis; in conditions that can lead to hyperkalemia, such as acute dehydration, extensive tissue damage, including severe burns. In this category of patients, it is recommended to regularly examine the level of electrolytes in the blood plasma.

During pregnancy and breastfeeding. So far, no danger has been reported when using the drug in this category of patients.

Children. Experience with the use of the drug in children is not enough.

The drug does not affect ability to drive vehicles and work with complex mechanisms.

when used simultaneously with potassium-sparing diuretics and / or ACE inhibitors, the risk of developing hyperkalemia increases.

cases of overdose are unknown. In case of an overdose, symptoms of hyperkalemia and hypermagnesemia can be observed.

Symptoms of hyperkalemia: general weakness, paresthesia, bradycardia, paralysis. An extremely high concentration of potassium in the blood plasma can lead to death from cardiac depression, arrhythmias, or cardiac arrest.

Symptoms of hypermagnesemia: nausea, vomiting, drowsiness, arterial hypotension, bradycardia, weakness, slurred speech, double vision. At very high plasma concentrations of magnesium, hyporeflexia, muscle paralysis, respiratory arrest, and cardiac arrest may develop.

In case of overdose, it is necessary to cancel K + -, Mg 2+ -aspartate and symptomatic treatment is recommended (calcium chloride 100 mg / min IV, dialysis if necessary).

at a temperature not exceeding 30 °C.