The good old drug "Analgin": what helps, and when it harms. Indications and contraindications for use, other characteristics of the drug

Symptoms of fever are eliminated by various drugs. Many adults take medication without thinking about the possible consequences for the body. However, when it comes to treating a child, parents are wary of choosing medications. Analgin is a well-known remedy used for temperature and pain syndromes. From what age can a child drink it?

Description of the drug

Analgin is a simple antipyretic and analgesic drug that has a weak anti-inflammatory effect. It consists of a synthetic substance - metamizole sodium. The peculiarity of the drug is that it quickly drowns out pain and lowers body temperature. However, the medicine itself does not eliminate the causes of the disease, so its effect lasts only 2 hours.

Analgin is produced in the form of tablets, solutions for injections and rectal suppositories. The drug is used both in pure form and in combination with other drugs. For children, tablets of 50, 100, 150 mg of metamizole sodium are produced. The ampoules contain 250 and 500 mg of a liquid substance (per 1 or 2 ml). Children's rectal suppositories are produced in a dosage of 200 mg.

Is it possible to give Analgin to children and in what situations?

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There are many doubts about the use of Analgin in pediatrics. The drug has many side effects, so it should not be taken uncontrollably. In some countries, they try not to use the medicine at all in medical practice. However, due to the fact that it quickly relieves the symptoms of fever, many experts prescribe it to both adults and children.

Analgin can be taken only as prescribed by a doctor from 3 months in the form of suppositories. It is prescribed in the case when other means do not cope with their task, it is necessary to bring down the temperature very quickly or it is not possible to use another drug.

The drug is used to relieve pain and relieve high temperature

Analgin is given to children in the following situations:

• severe headaches;
• to relieve toothache;
• intestinal, biliary and renal colic;
• pain in muscles and joints;
• feverish state;
• post-traumatic pain, burns;
• body temperature above 39 degrees (for example, with angina).

Contraindications

Before you give Analgin to children, you need to familiarize yourself with the contraindications, which are as follows:

• children's age up to 3 months;
• allergic reaction to metamizole sodium or its derivatives;
• agranulocytosis;
• violation of hematopoietic processes (for example, congenital anemia, porphyria);
• intolerance to analgesics;
• bronchial asthma;
• liver and kidney failure;
• low blood pressure;
• simultaneous reception with antibacterial drugs.

Side effects

Preparations based on metamizole sodium can cause negative reactions of the body, which are especially acute in babies. In most cases, the deplorable consequences of using the medication occur when taken incorrectly. However, even with strict adherence to the doctor's recommendations, it is necessary to carefully monitor the body's reaction to the drug.

Uncontrolled intake of Analgin can provoke an excessive decrease in blood pressure and loss of strength.

Possible side effects:

• a decrease in the level of leukocytes in the blood and an increase in the content of granulocytes and monocytes (agranulocytosis) (we recommend reading:);
• development of an acute allergic reaction (Quincke's edema, anaphylactic shock);
• decrease in body temperature below 35 degrees;
• disruption of the heart and kidneys;
• lowering blood pressure;
• decrease in the level of platelets in the blood;
• fainting state;
• aggravation of toothache after discontinuation of the medicine.

How does an overdose manifest itself?

Violating the dosage of the drug is strictly prohibited. Analgin is rapidly absorbed in the intestine, so the use of a large amount of medication creates a high concentration in the blood in the shortest possible time. Some people systematically use the medicine for toothache, but this cannot be done (we recommend reading:). Many do not understand why this is dangerous.

One-time consumption of an excess dose of the drug and the constant abuse of the drug manifest themselves in different ways. The gradual accumulation of a substance in the body causes the development of inflammatory processes.

A person develops mouth ulcers, aggravated pharyngitis and bronchitis. The poisonous effect of the drug provokes shortness of breath, cough, difficulty with urination, yellow skin staining.

With a single use of a large dose of the drug, the symptoms appear both immediately and within 3 days. The patient may develop stomatitis, inflammation of the gums, ulcers in the stomach and intestines, inflammation of the urinary tract. In addition to the above, drug overdose is expressed in the following symptoms:

• nausea and vomiting;
• convulsions;
• noise in ears;
• acute agranulocytosis;
• a sharp decrease in pressure;
• rapid contraction of the heart muscle;
• pain and pain in the abdomen;
• neuralgic disorders;
• loss of consciousness;
• coma.

Instructions for use and dosage

The use of the drug to quickly reduce high fever and relieve pain in children is allowed in emergency cases. Babies under 2 years old are recommended to use rectal suppositories. Liquid Analgin is administered to children intramuscularly. Drinking the drug is not recommended for longer than 3-4 days in a row.

Instructions for use and dosage of Analgin for children are described in the table.

Dosage form	Child's age	Dosage	Multiplicity of reception
Rectal suppositories (200 mg metamizole sodium)	3–12 months	0.5 candles	single dose
	1–3 years	1 suppository
	3–7 years	400 mg	Daily dose
	over 7 years old	600 mg
Tablets (50, 100, 150 mg active ingredient)	2–3 years	50–100 mg	2-3 times a day
	4–5 years	100–200 mg
	6–7 years	200 mg
	over 8 years old	250–300 mg
Injection	More than 3 months	Depending on the weight of the child: body weight * 5–10 mg	The daily dose is divided into 2-3 injections

Lytic mixture and other drug combinations

In emergency situations, when antipyretics do not cope with high fever, doctors use a lytic mixture. Its use is advisable in case of a sharp deterioration in the patient's condition, in which, against the background of fever, pale, dry and cold skin, blue extremities and lips are observed. These symptoms are typical for angina.

In emergency cases, when neither pills nor rectal suppositories can bring down the fever, doctors use a lytic mixture.

The composition of the mixture includes solutions of Analgin, Dimedrol and Papaverine for injections. Suprastin is often used instead of Dimedrol as an antihistamine for children (we recommend reading:). The action of the combined drug occurs within 15 minutes. The dosage is calculated depending on the age and weight of the patient.

When an injection cannot be made, you can prepare a mixture of Analgin, Paracetamol and Suprastin tablets (we recommend reading:). To do this, they must be mixed in the ratio: ¼ analgesic, ½ Paracetamol, 1/3 antihistamine. Toddlers who cannot swallow pills can be given an enema.

The procedure is done with the help of an analgesic ampoule, Diphenhydramine and clean water. The enema solution should be warm. The effect of the drugs will appear within 10 minutes. However, it is not recommended to give an enema to a child on their own. Various symptoms against the background of high temperature are also removed with the help of other combinations of Analgin:

• Spasms with intense heat: Analgin in injections is mixed with Suprastin and No-shpa. No-shpa relieves spasm and eliminates the pain effect. However, this drug can adversely affect a small patient, so No-shpu must be clearly dosed in accordance with the age of the patient (we recommend reading:).
• Fever with viral infections: Analgin + Aspirin.
• The pain syndrome is removed with the help of an analgesic mixed with Novocaine.
• Severe fever with angina: analgesic with Paracetamol (we recommend reading:).
• To relieve an excited state, a solution of Analgin and Dimedrol is used, selecting a dosage for children in accordance with age.

The use of combined mixtures for children is possible only after prior consultation with a doctor. If parents have observed allergic reactions to drugs in a child before, then it is necessary to give the baby medications with Analgin only under the supervision of medical personnel.

Name:

Name: Analgin (Analginum)

Indications for use:
Analgin is used for pains of various origins (headache, neuralgia - pain spreading along the nerve, radiculitis, myositis - inflammation of the muscles), feverish conditions (a sharp increase in body temperature), influenza, rheumatism.

Pharmachologic effect:
Analgin has very pronounced analgesic (pain reliever), anti-inflammatory and antipyretic properties. As a highly soluble and easily absorbed product, it is particularly suitable for use in cases where it is necessary to quickly create a high concentration of the product in the blood. Good solubility makes it possible to widely use analgin for parenteral (bypassing the gastrointestinal tract) administration.

Analgin method of administration and dose:
Assign analgin inside, intramuscularly or intravenously.
Inside take after a meal. Dose for adults - 0.25-0.5 g 2-3 times every day; with rheumatism - up to 1 g 3 times every day. Children inside - 5-10 mg / kg 3-4 times a day.
Intramuscularly or intravenously (with severe pain), adults are administered 1-2 ml of a 50% or 25% solution 2-3 times every day; no more than 2 g per day. Children are administered at the rate of 0.1-0.2 ml of a 50% solution or 0.2-0.4 ml of a 25% solution per 10 kg of body weight.
Do not apply subcutaneously, as tissue irritation is possible.
Higher doses for adults inside: single - 1 g, daily - 3 g; intramuscularly and in a vein: single - 1 g, daily - 2 g.

Analgin contraindications:
The drug is contraindicated in case of hypersensitivity (skin reactions, etc.), bronchospasm (narrowing of the bronchial lumen), hematopoietic disorders.

Analgin side effects:
When using analgin (especially for a long time), hematopoiesis may be suppressed (granulocytopenia / decrease in the content of granulocytes in the blood /, agranulocytosis / absence of granulocytes in the blood /), so it is necessary to periodically conduct blood tests.
Cases of allergic reactions after taking analgin and anaphylactic (allergic) shock after intravenous administration of the product are described.

Release form:
Powder, tablets of 0.5 g; 25% and 50% solutions in ampoules of 1 and 2 ml.
For use in pediatric practice, tablets of 0.05 are also produced; 0.1 and 0.15 g.

Synonyms:
Metamizole sodium, Metamizole, Dipyrone, Ronalgin, Algocalmine, Algopirin, Metapirin, Methylmelubrine, Minalgin, Noramidopyrinmethanesulfate sodium, Novaldin, Novamidazofen, Novapirin, Nosan, Nobolon, Devalgin, Ivalgin, Pantalgan, Piretin, Pyridon, Totalgin, Vetalgin, Analgetin, Neomelubrin, Novalgin , Novaminosulfone, Piralgin, Pirizan, Sulpirin, Toralgin.

Storage conditions:
List B. In well-corked orange glass jars in a place protected from light.

Analgin composition:
1-Phenyl-2,3-dimethyl-4-methylaminopyrazolone-5-N-methanesulfonate sodium.
White or white with a barely noticeable yellowish tint crystalline powder. Decomposes rapidly in the presence of moisture. Easily soluble in water (1:1.5), difficult - in alcohol.
An aqueous solution (pH 6.0 - 7.5) is sterilized at + 100 C for 30 minutes.

Analgin is a drug from the group of non-steroidal anti-inflammatory drugs (NSAIDs), which has a pronounced antipyretic (antipyretic) and analgesic effect. Therefore, Analgin is used as an anesthetic or antipyretic drug to relieve pain and normalize body temperature, provoked by any reason.

Unlike other drugs of the NSAID group, Analgin has a minimally pronounced anti-inflammatory effect, therefore, it is practically not used to reduce inflammation of any localization.

In this article, we will consider why doctors prescribe Analgin, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Analgin can be read in the comments.

Composition and form of release

According to the instructions for use, Analgin is available in tablets, rectal suppositories and ampoules (solution for intramuscular and intravenous use). For children, analgin is produced in the form of rectal suppositories and tablets.

• Active ingredient: metamizole sodium salt; 1 tablet contains metamizole sodium salt 500 mg; potato starch, calcium stearate, talc.

Usually, all varieties of the drug are simply called “Analgin”, but in some cases, when it comes to any particular dosage form, a qualifying word is added, for example, “Analgin for children”, “Analgin tablets”, “Analgin candles”, “Analgin injections " etc.

What helps Analgin?

The use of Analgin will help with pain syndromes of various origins: headaches and migraine pains, neuralgia, myalgia, toothache, algomenorrhea, chorea, rheumatism, sciatica, febrile conditions caused by infectious and inflammatory diseases.

Also, the drug is used in surgical practice to eliminate postoperative pain. With renal and biliary colic, the use of Analgin is effective in combination with antispasmodic drugs.

pharmachologic effect

It is a derivative of pyrazolone. It is characterized by a pronounced analgesic, antipyretic and slight anti-inflammatory effect.

1. The anti-inflammatory effect of metamizole is also due to the inhibition of prostaglandin production.
2. The antipyretic effect of Analgin is ensured by the ability to reduce the production and release of chemical substances that affect heat production.
3. The analgesic effect is provided by the ability of the active substance to inhibit cyclooxygenase and the synthesis of prostaglandins (they take part in the development of inflammatory and pain reactions). In addition, metamizole blocks the transmission of pain impulses and increases the sensitivity threshold of pain centers, reduces the response of brain structures to pain caused by a particular stimulus.

Analgin also has an antispasmodic effect on the smooth muscles of the biliary and urinary tract.

Instructions for use

According to the instructions for use, analgin is prescribed orally, intramuscularly or intravenously. The dosage depends on the intensity of pain, fever and individual response to taking Analgin. The lowest effective dose to control pain and fever should be chosen. Tablets should be swallowed whole, with sufficient liquid (eg a glass of water).

• Inside take after a meal. Dose for adults - 0.25-0.5 g 2-3 times a day; with rheumatism - up to 1 g 3 times a day. Children inside - 5-10 mg / kg 3-4 times a day.
• Intramuscularly or intravenously (with severe pain), adults are administered 1-2 ml of a 50% or 25% solution 2-3 times a day; no more than 2 g per day. Children are administered at the rate of 0.1-0.2 ml of a 50% solution or 0.2-0.4 ml of a 25% solution per 10 kg of body weight.

Higher doses for adults inside: single - 1 g, daily - 3 g; intramuscularly and in a vein: single - 1 g, daily - 2 g. High doses should be avoided in patients with reduced renal or hepatic function. Perhaps short-term use without dose reduction. Long-term use is not possible. Long-term treatment requires regular blood monitoring, including counting white blood cells.

Contraindications

The annotation lists the following contraindications to the use of Analgin:

• hypersensitivity to metamizole sodium, to other components of the drug and / or pyrazolone derivatives (propyphenazone, aminophenazone, phenazone);
• oppression of hematopoiesis (agranulocytosis, neutropenia, leukopenia);
• anemia, including hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase;
• asthma caused by acetylsalicylic acid;
• renal and / or liver failure;
• pregnancy;
• the period of breastfeeding;
• age up to 15 years.

In pediatric practice, tablets are used from the age of ten, suppositories - in children older than a year. Intramuscularly, the drug should not be administered to children under three months, as well as children weighing up to five kilograms. A contraindication for intravenous administration of Analgin is children's age from three to eleven months.

Side effects

Side effects when using Analgin can manifest themselves as:

1. Allergic reactions: urticaria (including on the conjunctiva and mucous membranes of the nasopharynx), angioedema, in rare cases, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), bronchospastic syndrome, anaphylactic shock.
2. From the urinary system: impaired renal function, oliguria, anuria, proteinuria, interstitial nephritis, urine staining red.
3. On the part of the hematopoietic organs: agranulocytosis, leukopenia, thrombocytopenia.

Others: decrease in blood pressure. Local reactions: with i / m administration, infiltrates are possible at the injection site.

Analogues

Synonyms of Analgin are the following drugs:

1. Baralgin and Baralgin M;
2. Metamizole sodium;
3. Spazdolzin.

Analogues with a similar mechanism of action: Akophil, Antipyrine, Bralangin, Pentabufen, Revalgin, Spasmolgon, Tetralgin.

Prices

The cost of various forms of Analgin in different pharmacies varies within the following limits:

• Tablets 500 mg, 10 pieces - 6 - 45 rubles;
• Tablets 500 mg, 20 pieces - 25 - 73 rubles;
• Analgin-Quinin tablets, 20 pieces - 51 - 80 rubles;
• Solution 50% (500 mg per 1 ml), 10 ampoules of 2 ml - 90 - 135 rubles.

Terms and conditions of storage

The drug is stored in its original packaging, protected from sunlight and moisture, out of the reach of children at a temperature not exceeding 25 °C. The shelf life of Analgin tablets is 5 years. You can not use the drug after the expiration date indicated on the package.

Terms of sale

Tablets are released without a prescription. A prescription is required to purchase suppositories and injection solution.

Allochol tablets: instructions, reviews, analogues Champix tablets: instructions, reviews, analogues

Analgin is an effective analgesic (pain reliever) drug that helps to quickly eliminate moderate or severe pain in the body.

In addition to the analgesic effect, the drug has a pronounced anti-inflammatory property, which can significantly reduce the resulting area of ​​the inflammatory process.

The drug allows you to quickly eliminate pain, so it can be easily used to relieve (eliminate) pain of a completely different nature and intensity (toothache or headache, various injuries, pain during menstruation, acute inflammatory diseases accompanied by severe pain syndrome, etc.) .

Quite effectively, Analgin helps with abdominal pain (intestinal colic), since the drug has a good antispasmodic effect, while it can be safely combined with antispasmodics No-shpa or Papaverine.

The main indications for the use of Analgin:

• acute or chronic inflammatory diseases of the respiratory system of the body, which are accompanied by fever and pain (bronchitis, tracheitis, pneumonia);
• severe toothache or headache;
• fever;
• renal or hepatic colic (Analgin is mainly used in combination with antispasmodics);
• neuralgia;
• severe pain in the heart;
• pain syndrome during menstruation in women;
• injuries of a different nature (bruise, slaughter, dislocation, sprain, fracture, etc.);
• burn;
• diseases of the musculoskeletal system (sciatica, rheumatism, arthritis);
• migraine;
• postoperative period;
• intestinal colic;
• myocarditis;
• pain syndrome in acute pancreatitis.

Remember: before using Analgin, it is recommended to consult with a general practitioner in order to prevent the possible development of an allergic reaction to this medication.

The drug is produced in the form of tablets of 250 or 500 mg, children's rectal suppositories (candles), as well as an injection solution for intramuscular, subcutaneous or intravenous administration.

How to drink Analgin?

The minimum interval (length of time) between taking Analgin tablets should be at least 4-6 hours. The average course of treatment is 5-7 days.

For children, the average dose of Analgin in tablets is ½ - ¼ tons (125/250 mg.) 2-3 r. per day, depending on the age of the child. In the form of an injection solution, the daily dose of the drug is calculated based on the specific age of the child and is 0.1 ml. for each year of life (for example: for a child of 2 years old, the daily dose of Analgin is 0.2 ml., Similarly for 7 years old - 0.7 ml.).

Attention: the drug is used only for short-term analgesia (pain relief), while Analgin is categorically contraindicated for long-term or frequent use.

Contraindications to the use of Analgin

• individual intolerance to the main constituent substances of the drug by the body;
• it is not recommended to administer to children under 1 year of age;
• liver and kidney failure;
• dysmenorrhea;
• pregnancy.

Side effects of Analgin

The most frequent adverse reactions after prolonged use of Analgin are.

Analgin (international non-proprietary name - metamizole sodium) is a non-narcotic anesthetic from the group of pyrazolone derivatives used for pain syndrome of a wide variety of etiologies: from headaches to postoperative pain. It has analgesic, antipyretic and weak anti-inflammatory effects due to blockade of the cyclooxygenase enzyme and inhibition of the formation of the mediator of pain and inflammation of prostaglandin from arachidonic acid. Analgin prevents the spread of pain impulses along the conduction pathways, reduces the excitability of thalamic pain centers, and increases the body's heat transfer. The anti-inflammatory effect of the drug, as already mentioned, is extremely weak, which also has its positive role: the absence of a negative effect on water-salt metabolism (retention of sodium and water ions) and the mucous membrane of the digestive tract. Analgin also has a weak antispasmodic effect, manifested by a slight decrease in the tone of the smooth muscles of the genitourinary tract and biliary tract.

When taken orally, the effect of the drug is felt after 20-40 minutes and reaches its peak after 2 hours. Analgin is available in two dosage forms: tablets and solution for intravenous and intramuscular administration. For adults and children aged 14 years and over, a single dose is ½-1 tablet (250-500 mg) 2-3 times a day after meals. The largest single dose - 2 tablets (1 g), daily - 6 tablets (3 g).

Given the likelihood of developing unwanted side effects, the following time intervals have been established for the duration of taking analgin: no more than 3 days as an antipyretic and no more than 5 days as an analgesic. With prolonged use, and this means a weekly therapeutic course of the drug, mandatory monitoring of blood parameters and the functional state of the liver is indicated. For children under 14 years of age, analgin is prescribed in accordance with body weight at the rate of 5-10 mg per 1 kg 3-4 times a day, after crushing the tablet. The course of treatment in this case should not exceed 3 days. The injection form of analgin is administered intravenously or, with severe pain, intramuscularly.

In medical practice, with prolonged use of analgin, there have been cases of overdose, the signs of which are nausea, vomiting, abdominal pain, chills, lowering blood pressure, palpitations, shortness of breath, tinnitus, drowsiness. In such cases, it is recommended to provoke vomiting, wash the stomach, take activated charcoal and a saline laxative.

In acute gastralgia, taking analgin is possible only after the final determination of the causes of pain. Given the not the best reputation of this drug in terms of adverse reactions, the use of analgin in children under the age of 18 is recommended only after consulting a doctor.

Pharmacology

Analgesic-antipyretic. It is a derivative of pyrazolone. It has analgesic, antipyretic and anti-inflammatory effects, the mechanism of which is associated with inhibition of prostaglandin synthesis.

Pharmacokinetics

After oral administration, metamizole sodium is rapidly hydrolyzed in gastric juice to form the active metabolite 4-methyl-amino-antipyrine, which, after absorption, is metabolized to 4-formyl-amino-antipyrine and other metabolites. After intravenous administration, metamizole sodium quickly becomes inaccessible for determination.

Metabolites of metamizole sodium do not bind to plasma proteins. The largest part of the dose is excreted in the urine in the form of metabolites. Metabolites are excreted in breast milk.

Release form

2 ml - dark glass ampoules (10) - blister packs (1) - cardboard packs.
2 ml - dark glass ampoules (10) - blister packs (10) - cardboard boxes.

Dosage

Inside or rectally, adults are prescribed 250-500 mg 2-3 times / day. The maximum single dose is 1 g, the daily dose is 3 g. Single doses for children aged 2-3 years are 50-100 mg; 4-5 years - 100-200 mg; 6-7 years - 200 mg; 8-14 years - 250-300 mg; the multiplicity of reception - 2-3 times / day.

In / m or / in slowly for adults - 250-500 mg 2-3 times / day. The maximum single dose is 1 g, the daily dose is 2 g. In children, it is used parenterally at a dose of 50-100 mg per 10 kg of body weight.

Interaction

With simultaneous use with analgesics, antipyretics, with NSAIDs, mutual enhancement of toxic effects is possible.

With simultaneous use with inducers of microsomal liver enzymes, the effectiveness of metamizole sodium may decrease.

With simultaneous use, the activity of indirect anticoagulants, oral hypoglycemic drugs, GCS, indomethacin increases due to their displacement from the connection with blood proteins under the influence of metamizole sodium.

With simultaneous use with phenothiazine derivatives, severe hyperthermia is possible; with sedatives, anxiolytics - the analgesic effect of metamizole sodium is enhanced; with tricyclic antidepressants, oral contraceptives, allopurinol - the metabolism of metamizole sodium is disturbed and its toxicity increases; with caffeine - the effect of metamizole sodium is enhanced; with cyclosporine - the concentration of cyclosporine in the blood plasma decreases.

When metamizole sodium is used in combination with pitophenone hydrochloride (it has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation) and with fenpiverinium bromide (m-anticholinergic blocker), their pharmacological action is mutually enhanced, which is accompanied by a decrease in pain syndrome, relaxation of smooth muscles and decrease in elevated body temperature.

Side effects

Allergic reactions: skin rash, angioedema; rarely - anaphylactic shock.

From the hemopoietic system: rarely, with prolonged use - leukopenia, agranulocytosis.

Local reactions: with i / m administration - infiltrates at the injection site.

Indications

Pain syndrome of various origins (renal and biliary colic, neuralgia, myalgia; with injuries, burns, after operations; headache, toothache, menalgia). Fever in infectious and inflammatory diseases.

Application for violations of liver function Contraindicated in severe violations of kidney function.

Application for violations of kidney function

Use in children

Single doses for children aged 2-3 years are 50-100 mg; 4-5 years - 100-200 mg; 6-7 years - 200 mg; 8-14 years - 250-300 mg; the multiplicity of reception - 2-3 times / day.

special instructions

With prolonged use, it is necessary to control the picture of peripheral blood.

Metamizole sodium is used in combination with pitophenone and fenpiverinium bromide as an analgesic with antispasmodic action.

Use with caution in children in the first 3 months of life.