The meaning of the word biyoquinol in the reference book of medicines. Antisyphilitic drugs Indications for use

Name:

Bioquinol (Biiochinolum)

Pharmachologic effect:

It has a therapeutic effect in spirochetosis (human diseases caused by spiral-shaped microorganisms), as well as anti-inflammatory and resolving effects.

Indications for use:

All forms of syphilis (in combination with penicillin preparations), non-specific lesions of the central nervous system: arachnoencephalitis (inflammation of the membranes and tissues of the brain), meningomyelitis (simultaneous inflammation of the membranes and tissues of the spinal cord), etc., skull trauma.

Application method:

With nonspecific lesions of the central nervous system, 2 ml every other day. Heading dose - 30-40 ml, depending on the stage of the process.

Undesirable phenomena:

Possible salivation, gingivitis (inflammation of the mucous membrane of the gums), stomatitis (inflammation of the oral mucosa), dermatitis (skin inflammation), bismuth nephropathy (kidney damage due to treatment with biyoquinol), albuminuria (protein in the ureters), polyneuritis (multiple inflammation of the peripheral nerves) and trigeminal neuritis (inflammation of the facial nerve).

Contraindications:

Age up to 6 months. Diseases of the kidneys, liver, hemorrhagic diathesis (increased bleeding), severe forms of tuberculosis, cardiac decompensation (a sharp decrease in the pumping function of the heart), gingivitis (inflammation of the gum mucosa), stomatitis (inflammation of the oral mucosa), hypersensitivity to quinine.

Release form of the drug:

In bottles of 100 g.

Storage conditions:

Preparation from list B. In a cool, dry, dark place.

Similar drugs:

Bismoverol (Bismoverolum)

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Bioquinol has a therapeutic effect in spirochetosis (the drug has a specific effect on spirochetes), and also has an anti-inflammatory and resolving effect.

Indications for use

All forms of syphilis in adults and children (in combination with penicillin preparations), various forms of neurosyphilis, non-syphilitic lesions of the central nervous system (arachnoencephalitis, arachnoiditis, meningomyelitis, etc.), skull trauma.

Positive results are observed in the treatment of furunculosis, lupus erythematosus, parapsoriasis, lichen planus and sluggish inflammatory processes with Bioquinol.

Application rules

Bioquinol is injected intramuscularly at 1–3 ml into the upper outer quadrant of the buttock in a two-stage manner 1 time in 2–3 days. For a course of treatment, up to 50 ml of the drug is administered.

Before injection, the bottle is heated by immersion in warm water (not higher than 40 ° C) and shaken thoroughly.

In case of syphilis, 2-3 ml is administered intramuscularly once every 2-3 days (at the rate of 1 ml per day). The heading dose of the drug is 40-50 ml.

In case of non-specific lesions, lesions of the central nervous system are prescribed 1 ml of Bioquinol 1 time per day or 2 ml every other day. The heading dose is 30–40 ml, depending on the stage of the process.

The highest single dose of Bioquinol for adults intramuscularly is 3 ml (1 time in 3 days). For children, the drug is prescribed according to age.

Side effects

Possible phenomena of irritation of the liver, kidneys, salivation (salivation), the appearance of a "bismuth border" (dark blue border along the edge of the gums), gingivitis, stomatitis, dermatitis, urticaria, erythema, bismuth nephropathy, albuminuria, polyneuritis and trigeminal neuritis.

Treatment with Bioquinol should be accompanied by urine tests, the use of antiseptic rinses and monitoring of the oral cavity.

The occurrence of complications requires a break in treatment and the appointment of Dimedrol, calcium chloride.

Contraindications to the use of Bioquinol

Age up to 6 months. Diseases of the kidneys, liver, diabetes mellitus, hemorrhagic diathesis, severe forms of tuberculosis, cardiac decompensation, gingivitis, stomatitis, amphodontosis, increased individual sensitivity to quinine.

Composition and form of release

Prescription for Bioquinol

Rp.:	Bijochinoli	100,0
	D.S.

Bioquinol - 8% suspension of quinine iodobismuthate in neutralized peach or olive oil.

Produced in bottles of 100 ml.

Shelf life and storage conditions

Store in a cool, dry place protected from light.

The shelf life of Bioquinol is 3 years.

Properties

Bioquinol(Bijochinolum) is a brick-red liquid that forms a brick-red precipitate on standing.

Bioquinol (Biiochinolum)

Pharmacological action of the drug.

It has a therapeutic effect in spirochetosis (human diseases caused by spiral-shaped microorganisms), as well as anti-inflammatory and resolving effects.

What is used for. Indications for the use of the drug.

All forms of syphilis (in combination with penicillin preparations); non-specific lesions of the central nervous system: arachnoencephalitis (inflammation of the membranes and tissues of the brain), meningomyelitis (simultaneous inflammation of the membranes and tissues of the spinal cord), etc .; skull trauma.

Dosage and method of application.

Intramuscularly in the upper outer quadrant of the buttocks, in a two-stage way. Before injection, the vial is heated in warm water and shaken thoroughly. With syphilis - 3 ml every fourth day. The course dose is 40-50 ml. The highest single dose for adults is 3 ml (every 3 days). Children according to age.
With nonspecific lesions of the central nervous system, 2 ml every other day. Heading dose - 30-40 ml, depending on the stage of the process.

Side effects and actions of the drug.

Contraindications and negative properties.

Release form. Package.

In bottles of 100 g.

Terms and conditions of storage.

List B. In a cool, dry, dark place.

The main active ingredient of the drug.

quinine iodobismuthate

Important!

Description of the drug Bioquinol» on this page is a simplified and supplemented version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the annotation approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, as well as determine the dose and methods of its use.

BIYOQUINOL (biochinolum; cn. B) - antisyphilitic agent; 8% suspension of quinine iodobismuthate in neutralized peach oil. 1 ml of suspension contains 0.02 g of metallic bismuth; on standing, a brick-red precipitate forms.

B. has chemotherapeutic activity against treponema and especially Trep. pallidum. The mechanism of chemotherapeutic action is poorly understood. It is supposed that B. blocks sulfhydryl groups of enzymatic systems of a treponema. The drug also has an anti-inflammatory effect. This combination of properties contributes to the rapid resorption of syphilides and the death of treponema, while serological reactions are normalized.

Apply B. to treat all forms of syphilis. The anti-inflammatory properties of the drug make it possible to use it in the treatment of non-syphilitic inflammatory processes in c. n. N of page, and also at the residual phenomena of disturbance of cerebral circulation.

With syphilis, appoint 3 mg 1 time in 3 days. The dose for the course of treatment is 40-50 ml, or 0.8-1 g of metallic bismuth. In elderly patients with vascular changes in c. n. from. treatment begins with 0.5 doses, gradually increasing. The highest single dose for adults is 3 ml (1 time in 3 days). B. children are prescribed according to age also 1 time in 3 days: up to 6 months - 0.3-0.5 ml, only 8 ml; up to 1 year - 0.5-0.8 ml, only 10 ml; from 1 year to 3 years - 0.5-1 ml, total 12-15 ml; from 3 to 5 years - 1-1.5 ml, total 15-20 ml; from 5 to 10 years - 1-2 ml, total 20-25 ml; from 10 to 15 years - 1-3 ml, only 25-30 ml. The number of courses depends on the stage of the process. B. can also be used on an outpatient basis. In non-syphilitic inflammatory processes, B. is prescribed 1 ml daily.

The drug is injected intramuscularly into the upper outer quadrant of the buttock with a needle 5-6 cm long. Before use, B. is heated in a water bath at t ° 37 °. The vial is thoroughly shaken until a homogeneous, brick-red suspension is obtained. When administering the drug, it is necessary to ensure that the needle does not enter the lumen of the vessel (if B. enters the bloodstream, severe pain in the legs and buttocks, pulmonary embolism may occur). After inserting the needle, they check if blood has appeared from the cannula, and only after making sure that there is no blood, they attach the syringe and slowly inject the drug; when blood appears, it is recommended to remove the needle and make a secondary injection.

In the body, bismuth accumulates in the bones, spleen, liver and kidneys; it is excreted slowly (within 3 months), mainly with urine and partly with feces: only approx. 50% metallic bismuth. With repeated treatment, the content of bismuth in the body increases significantly. It is necessary to carefully monitor kidney function: when epithelial cells with bismuth inclusions (so-called bismuth cells) appear in the urine, treatment is stopped.

With the usual dosage and the correct technique of administration, side effects and complications are rare. In some cases, a gray stripe appears along the edge of the incisors and carious teeth - a “bismuth border”, therefore, in order to prevent gingivitis and stomatitis, great attention should be paid to oral hygiene.

B. is contraindicated in kidney disease, idiosyncrasy to quinine, gingivitis, stomatitis, amphodontosis, diabetes, hemorrhagic diathesis, tuberculosis, and cardiac decompensation.

The drug is produced in orange glass bottles of 100 ml. Store in a cool, dark place. Abroad, similar drugs are known under the names of bismoquine, bismos, bismiosalvan, yobikhin, spirobismol.

N. A. Novitskaya.

Antisyphilitic there are drugs used to treat syphilis with the aim of selectively influencing its causative agent, pale treponema (Treponemapallidum). They belong to the group of protispirochetosis drugs, they are also prescribed for the treatment of other spirochetosis (for example, relapsing fever) and leptospirosis.

For drug therapy of all stages of syphilis, antibiotics are used. In the later stages of syphilis, iodine compounds are also prescribed to accelerate the resorption of rubbers. (potassium iodide ) or bismuth preparations (biyoquinol And bismoverol).

History reference. The first specific antisyphilitic drugs were organic compounds of arsenic ( salvarsan , novarsenol and others), which were invented by the founder of chemotherapy, the famous German scientist, Nobel laureate Paul Ehrlich in 1910.

P. Ehrlich suggested the effectiveness of such a compound in the treatment of trypanosomiasis ("sleeping sickness") to study the prosyphilitic activity of arsenic compounds. Due to high toxicity and insufficient efficacy, arsenic preparations have not been used in clinical practice for a long time.

(1854-1915)

Classification of antisyphilitic drugs

Origin antisyphilitic drugs are divided into

1. Antibiotics:

Benzylpenicillin preparations (salts benzylpenicillin - sodium, novocaine, benzathine or bicillin-1) and other penicillin antibiotics ( ampicillin, oxacillin)

Cephalosporins ( cefazolin, ceftriaxone)

Macrolides and azalides ( erythromycin, josamycin, azithromycin)

Tetracyclines (doxycycline).

2. Synthetic compounds:

Bismuth preparations ( biyoquinol, bismoverol).

By efficiency Antisyphilitic antibiotics are divided into 3 groups:

1. Fixed assets (and rows).

2. Alternative means (second row).

3. Reserve funds.

Fixed assets. Antisyphilitic drugs and a number of drugs are benzylpenicillin (sodium, potassium salts, as well as benzathine benzylpenicillin and others Bicillin), which are used intramuscularly. These antibiotics quickly kill the causative agent of syphilis, Treponema pallidum - they exhibit a treponemocidal effect. The causative agent of syphilis does not acquire resistance to antibiotics.

In some patients, at the beginning of antibiotic therapy, within a few hours after the first injection, the general condition of the patient worsens with the development of symptoms of intoxication - body temperature rises, headache, tachycardia, myalgia, and general weakness occur. Such a side effect of antibiotic therapy was called the Jarisch-Herxheimer Reaction (Jarisch - Herxheimer Reaction - named after the Austrian and German dermatologists who first described it after the use of mercury preparations in patients with syphilis. In the domestic literature it is known as the Herxheimer - Yarish - Lukashevich reaction). The reaction can also occur during antibiotic therapy of other infectious diseases due to the bactericidal action of antimicrobial agents - through the mass death of microorganisms and the rapid entry into the blood of a large number of endotoxins of dead bacteria. This side effect of antibiotic therapy is transient, disappears within one day, can be prevented and does not require special additional treatment. In the case of a general severe condition of the patient, for example, due to a syphilitic lesion of the aortic valve, the patient is given desensitizing agents - glucocorticoids in advance, before the start of antisyphilitic antibiotic therapy, to prevent the occurrence of the Jarisch-Herxheimer reaction.

Alternative means(means of the II series) is macrolides (erythromycin, josamycin) and tetracycline (doxycycline), they are used mainly for allergies to penicillins. Erythromycin is inferior in effectiveness to other drugs of the second row; in addition, it does not pass the hematoplacental barrier and does not have a therapeutic effect on the fetus. Therefore, newborns (in the case of pregnant women treated with erythromycin) are treated with benzylpenicillin preparations.

Rarely prescribed other antibiotics penicillin row (ampicillin, amoxicillin, oxacillin) and cephalosporins (cefazolin, ceftriaxone), which have a wide spectrum of antimicrobial activity, when there is a need for the simultaneous treatment of concomitant infections. Ceftriaxone has the ability to accumulate in the brain in high concentrations, so it is prescribed for neurosyphisis.

Reserve antisyphilitic drugs(means of the III row) consider azalides (azithromycin). In terms of effectiveness, reserve and alternative drugs are inferior to benzylpenicillin preparations.

Bismuth preparations. Complex preparations of bismuth (biyoquinol, bismoverol) are specific antisyphilitic drugs - they act on pale trepoiem and do not show a broad antibacterial effect. The type of antibacterial action is bacteriostatic (treponemostatic type of action). The mechanism of action is due to the blocking of sulfhydryl groups (SH-groups) of microbial enzymes. In terms of activity and speed of onset of the effect, bismuth preparations are inferior to antibiotics.

Bioquinol(biiochinolum) is an 8% suspension of quinine iodobismuthate in neutralized peach oil, i.e. contains bismuth (bi), iodine (io) and quinine (chin) in peach oil (oe). It has additional anti-inflammatory and resolving effects. It is produced in vials for parenteral (intra-hypnotic) injections of 100 mx, administered intramuscularly in 2 (3) ml 1 time in 2 (3) days, that is, at the rate of 1 ml per day.

Bismoverol(bismoverolum) - 7% suspension of the basic bismuth salt of monobismuth-tartaric acid in neutralized peach (or olive) oil.

Bismuth preparations are prescribed for all forms of syphilis in combination with antibiotics. They are especially effective in neurosyphilitic lesions. Bismuth preparations also have anti-inflammatory and resolving effects, so they are used for non-syphilitic lesions of the central nervous system (arachnoencephalitis, meningomyelitis, residual effects after cerebral strokes). They are not absorbed from the digestive tract, so they are administered intramuscularly. It is excreted mainly by the kidneys, as well as in small amounts by the intestines and sweat glands.

Side effects: gingivitis, stomatitis, the appearance of a gray border along the edge of the gums (bismuth border), gray spots on visible mucous membranes, colitis, diarrhea, dermatitis, nephropathy (relatively frequent, usually disappear after discontinuation of the drug), hepatitis. When using bismuth preparations, it is necessary to monitor the condition of the oral mucosa, kidney and liver function.