What can you drink instead of omeprazole from another group. Effective analogues of omeprazole

The drug "Omeprazole" (analogs: "Omez", "Losek", "Gastrozol", "Omegast", "Ultop", "Pepticum") is one of the most modern, and, therefore, effective medicines. A distinctive feature of such medications is the creation of conditions due to which the final stage of secretion is inhibited, regardless of what irritants caused it. This allows you to treat dangerous and complex ailments of the gastrointestinal tract.

"Omeprazole": analogues and their action

The description of Omeprazole and its analogues indicates that the drug begins to act fully after 2 hours after use. With a single daily use, the drug controls the amount of gastric juice throughout the day and creates comfortable and favorable conditions for the functioning of the digestive organs. At the same time, it participates in the inhibition of basal secretion and blocking of all its irritants, acts on acetylcholine and histamine receptors.

It should be noted that "Omeprazole" and "Omez" work effectively even in clinical cases with patients suffering from impaired renal and liver failure, since they are completely metabolized by the liver and excreted in the urine from the body.

"Omeprazole": analogues and their composition

The drugs are available in 20 mg capsules, each of which is coated with an enteric coating. The basis of the medicinal component is 5-methoxy benzimidazole. The excipients are sugar, lactose, diethyl phthalate, basic sodium phosphate and hydroxypropyl methylcellulose phthalate.

Medicines have their own indications and contraindications.
"Omeprazole" or "Omez" is prescribed when the body reacts poorly to H2 receptors. The drugs are indicated for stomach problems, erosive reflux esophagitis, peptic ulcers caused by exposure to Heliobacter, and ulcerative-erosive lesions of the stomach resulting from taking potent drugs. "Omez" will also help with erosive and ulcerative formations of the gastric mucosa caused by cirrhosis of the liver; it can be used to prevent acid aspiration and to relieve symptoms of pathological hypersecretory conditions.

"Omeprazole" should not be taken in cases of increased sensitivity to the components included in the drug. The medicine has no other contraindications, but with a long period of use of the drug, side effects may occur that quickly pass: headache, diarrhea, nausea, allergic reactions.

"Omeprazole": analogues, their dosage and use

According to the instructions for the drug, the capsules must be taken completely with water. If it occurs, take one capsule per day half an hour before meals. If necessary, the dose can be doubled. The course of treatment is four weeks.

For gastritis, the medicine is taken for two weeks, one capsule per day. The medicine guarantees the elimination of symptoms and hyperacidity of an irritated stomach.

If the body is infected with Heliobacter, omez in a double dose is taken in combination with amoxicillin 2 times a day for half a month.

For the treatment of reflux esophagitis, take 2 capsules of the drug Omeprazole. Synonyms and analogues are also suitable for treatment.

For preventive purposes, to prevent acid aspiration, omeprazole is taken 4 hours before bedtime.

If you miss taking the drug for any reason, you should not double the dose. This is fraught with unforeseen consequences. In such cases, you should consult a doctor to clarify the dosage.

Proton pump inhibitors are drugs used to reduce the production of hydrochloric acid in the stomach.

They are the most commonly prescribed medications. From 2009 to 2013, the number of PPI prescriptions increased by 20 million.

The results of the study confirmed their safety. And the minimal adverse reactions caused by proton pump inhibitors did not require their treatment.

But, nevertheless, drugs in this group have some side effects. Let's talk about them in more detail. But first, let’s look at the principle of action of PPIs and indications for their use.

Mechanism of action of proton pump inhibitors

How do proton pump inhibitors work? Drugs in this group block the activity of an enzyme that promotes the production of hydrochloric acid in the stomach.

Proton pump inhibitors also help eliminate the bacteria H. pylori from the body.

Helicobacter pylori is one of the causes of gastritis, gastric and duodenal ulcers and stomach cancer. Combined use of a PPI with an antibiotic removes the bacteria from the body.

Drugs in this group help to quickly relieve symptoms of ulcers, gastritis, GERD and, with a course of use, achieve long-term remission.

Indications for the use of proton pump inhibitors

For what diseases are PPIs prescribed? Omeprazole and its analogues are indicated for gastroesophageal reflux disease, gastric and duodenal ulcers, Zollinger-Ellison syndrome, and reflux esophagitis.

Gastroesophageal reflux disease

GERD is a chronic disease with episodes of exacerbation and remission. The pathological process occurs due to the reflux of gastric contents into the esophagus.

The disease is characterized by the presence of symptoms such as:

• heartburn. This term refers to a burning sensation behind the sternum that spreads to the neck and throat. Heartburn occurs due to contact of the contents of the stomach with the mucous membrane of the esophagus. It appears after drinking alcohol, spicy, fried, hot foods, bending the body down, after intense physical exertion;
• belching. Occurs in half of patients with GERD. This symptom is more pronounced after eating or drinking carbonated drinks. With prolonged physical exertion, regurgitation may occur;
• dysphagia – difficulty swallowing, and odynophagia – pain when swallowing. These symptoms occur due to impaired motor function of the esophagus. Pain when swallowing is a consequence of inflammation of the mucous membrane of the esophagus. Moreover, if the signs of swallowing disorders are severe, and at the same time heartburn has disappeared, this may indicate a narrowing of the lumen of the esophagus;
• pain along the esophagus. At the same time, patients feel that their heart hurts. But pain in heart disease occurs after physical exertion, and discomfort with GERD is not associated with exercise;
• increased salivation.
• otorhinolaryngological syndromes (from the ENT organs). The patient complains of soreness or a feeling of a lump in the throat, hoarseness.
• dental syndrome is characterized by the appearance of caries due to damage to the enamel by acid, the occurrence of ulcers in the oral cavity;
• bronchopulmonary syndrome – cough, bronchial asthma, shortness of breath.
• bloating;
• feeling of “quick satiety” while eating;
• nausea;
• pain in the epigastrium (in the navel and 2-3 cm above it).

Peptic ulcer of the stomach and duodenum

Peptic ulcer of the stomach and duodenum is a condition characterized by the presence of an ulcer in the stomach or intestines. The disease occurs with periods of exacerbation and remission.

• The main complaint of patients with ulcers is pain. It may be different. Patients characterize it as cutting, aching or burning. It is worth noting that ulcerative defects are characterized by periodicity of pain. That is, the pain either goes away or appears again. In addition, such symptoms are observed mainly in autumn and spring;
• pain associated with ulcers is typically associated with food intake ;
• belching. It can be sour in nature (with hypersecretion of gastric juice), food can come back out along with belching;
• vomiting, after which the condition improves significantly;
• heartburn;
• weight loss, because patients are afraid of pain after eating and try to eat less.

Esophagitis

Esophagitis is an inflammation of the esophageal mucosa due to various causes. Patients complain of pain in the chest and epigastrium (in the navel area and 2-3 cm above it) after swallowing food.

The same symptoms can occur during physical activity or wearing tightly constricting belts. Pain often appears when lying down.

In this case, the pain is paroxysmal and “radiates” to the heart, neck or back. The pain syndrome is accompanied by belching of air. Sometimes belching can release stomach contents.

Patients also complain of heartburn in the evening and at night. In addition, hiccups, excessive salivation, vomiting, nausea, and difficulty breathing are of concern.

Moreover, patients note that hiccups last a long time, and its occurrence is associated with belching.

Zollinger-Ellison syndrome

This pathology is associated with the appearance of a pancreatic tumor, which promotes increased gastrin formation.

The latter, in turn, causes increased formation of hydrochloric acid in the stomach, which leads to the appearance of ulcers in the stomach and intestines.

Patients note the presence of pain in the epigastrium, heartburn, sour belching, diarrhea (stools are “greasy”, profuse and watery), weight loss.

A characteristic feature of the disease is that ulcers do not heal for a long time, even with proper treatment. Characteristic signs of inflammation of the mucous membrane of the esophagus, sometimes its narrowing. Liver tumors are typical.

Contraindications to taking Omeprazole and its analogues

Under what conditions should Omeprazole not be taken? This drug and its analogues are contraindicated in:

• intolerance to the components of the drug;
• period of pregnancy and breastfeeding;
• gastritis with low acidity;
• atrophic gastritis;
• tumor of the stomach or duodenum. The drug can mask the symptoms of oncology, which interferes with its timely diagnosis;
• osteoporosis;
• infections – salmonellosis, campylocabter, etc.;
• chronic liver pathologies. Since the drug is metabolized specifically in the liver, chronic failure of the function of this organ leads to the accumulation of Omeprazole in the liver cells and their toxic damage;
• renal dysfunction.

Omeprazole preparations

What medications can replace Omeprazole? Omeprazole analogues include:

• Omeprazole Stada - prevents the production of hydrochloric acid in the stomach, reduces the production of insulin, and prevents the pathological effect of gastric juice on the mucous membrane of the esophagus;
• Gastrozol - indicated for stomach and duodenal ulcers, heartburn, reflux of gastric contents into the esophagus, ulcers caused by long-term use of non-steroidal anti-inflammatory drugs (NSAIDs);
• Omeprazole Acri - helps to quickly reduce the night and daytime secretion of hydrochloric acid;
• Omeprazole Nika - indicated for GERD;
• Omez – reduces the secretion of hydrochloric acid by the stomach;
• Pilobact - in addition to Omeprazole, contains two antibiotics. The drug is effective for gastric ulcers caused by the bacterium Helicobacter pylori;
• Omitox is a drug used for peptic ulcers of the stomach and intestines. Indicated for anti-relapse treatment of the disease;
• Omeprazole Richter - the medicine is contraindicated in liver pathologies;
• Orthanol - indications and contraindications are similar to those of Omeprazole;
• Ultop - normalizes the activity of hydrochloric acid in the stomach and reduces its production;
• Omeprazole Teva - the effect of the drug depends on the dose taken. Reduces the production of hydrochloric acid in the stomach, slows down the secretion of HCl;
• Bioprazole - indicated for peptic ulcers of the stomach and intestines;
• Omephesis - in addition to reducing the production of hydrochloric acid in the stomach, protects the cells of the mucous membrane;
• Losek - when interacting with antibacterial agents, it quickly relieves the symptoms of the pathology and promotes rapid healing of the damaged gastric mucosa. The drug also reduces the likelihood of bleeding from an ulcer;
• Hasek – accelerates the healing of ulcers.

Other proton pump inhibitors and their analogues

Let's consider other available proton pump inhibitors and their analogues:

• Pantoprazole – Nolpaza, Sanpraz, Controloc, Panum;
• Esomeprazole – Nexium;
• Lansoprazole - Epicur, Helicol, Lansofed, Lanzoptol, Lancid;
• Rabeprazole - Pariet.

Side effects

Side effects from taking Omeprazole and its analogues appear infrequently with prolonged use of a proton pump inhibitor:

• diarrhea or constipation;
• nausea and vomiting;
• dizziness and headache;
• flatulence;
• liver dysfunction;
• irritability;
• encephalopathy;
• depression;
• allergy;
• skin rashes;
• peeling and itching;
• redness;
• temperature increase;
• Quincke's edema;
• anaphylactic shock;
• hives;
• decrease in the number of red blood cells, leukocytes, platelets;
• soreness in muscles and joints;
• increased sensitivity to sunlight.

Now let's take a closer look at the side effects of other proton pump inhibitors.

Action during pregnancy

According to the results of studies that were conducted in 2010, taking proton pump inhibitors in the month before conception and in the first trimester of pregnancy was not accompanied by an increase in congenital malformations.

Therefore, proton pump inhibitors can be used at the beginning of pregnancy.

Development of oncology

Experiments on mice have shown that long-term use of proton pump inhibitors can cause pancreatic or colon cancer.

Data from studies of people taking proton pump inhibitors continuously (from 5 to 15 years) showed that the number of stomach cells increased, which could later lead to cancer.

However, after stopping the PPI, everything returned to normal within 2 weeks. There was no subsequent development of cancer.

It is also known that long-term use of Pantoprazole (Controloc) (more than 15 years) does not cause the development of any negative effects. The drug is well tolerated by patients.

Pantoprazole has shown its high effectiveness in diseases accompanied by increased acidity of gastric juice.

Development of infection

Based on research results, it is known that taking proton pump inhibitors can cause the development of pseudomembranous colitis, the causative agent of which is Clostridium difficile.

The disease more often appears in elderly patients, as well as those taking drugs other than PPIs (antibiotics, chemotherapy drugs).

The risk of infection also increases if you have inflammatory bowel disease or after organ transplantation.

Long-term use of proton pump inhibitors can lead to infections caused by Salmonella, Shigella, Escherichia, and Campylobacter.

Vitamin B 12 malabsorption

As a result of most studies, it has become known that long-term use (more than 2 years) of proton pump inhibitors can lead to impaired absorption of vitamin B12.

This occurs as a result of a decrease in the acidity of gastric juice. This condition leads to the development of anemia.

Iron malabsorption

Iron absorption occurs in the small intestine. The large amount of iron that a person consumes through food must undergo some transformations in order to be absorbed into the body.

This element is absorbed only after exposure to hydrochloric acid. Long-term use of PPIs causes a decrease in gastric acidity, interferes with iron absorption and leads to anemia.

Osteoporosis and bone fractures

Osteoporosis is a decrease in bone mineral density. The condition develops with long-term (more than 7 years) use of proton pump inhibitors.

The condition is associated with impaired absorption of vitamin B 12 and a decrease in the acidity of gastric juice.

The latter leads to an increase in the concentration of gastrin in the blood, due to which the parathyroid glands are stimulated. This process leads to the transfer of calcium from the bones into the blood.

A lack of vitamin B 12 and suppressed acidity in the stomach increases the risk of developing fractures.

Based on the results of the study, the following conclusion was made: there is no likelihood of bone fracture when taking small doses of proton pump inhibitors.

The risk of developing fractures of the wrist, spine and hip bones increases with long-term use (more than 7 years) of large doses of PPIs, with the initial presence of osteoporosis, a sedentary lifestyle, and a lack of vitamin D.

Taking proton pump inhibitors together with other drugs

Clopidogrel can be prescribed to patients with heart pathology. The drug reduces the likelihood of thrombosis.

According to the results of the study, the combined use of PPIs and Clopidogrel increases the likelihood of developing myocardial infarction, unstable angina, and coronary death. This effect is caused by Omeprazole and Esomeprazole.

Instead of Omeprazole and Esomeprazole, Pantoprazole can be taken along with Clopidogrel. It does not interact with Clopidogrel, Diclofenac, Clarithromycin, Diazepam, Cyclosporine, Warfarin and some other drugs.

Thus, Pantoprazole is the safest drug if it is necessary to take several medications at the same time.

The effect of PPI use on the development of dementia

It has recently become known that the likelihood of developing dementia increases in older people who take proton pump inhibitors for a long time.

A study was conducted in Germany that confirmed that dementia and Alzheimer's disease developed more often in those who took proton pump inhibitors.

However, another study showed that in addition to PPI use, cognitive impairment could be caused by diabetes, stroke, Parkinson's disease, increased levels of low- and very low-density lipoproteins, traumatic brain injury, heart disease, and excessive alcohol intake.

PPI use and systemic lupus erythematosus

When taking one proton pump inhibitor - Rabeprazole – The patients experienced the appearance of a cutaneous form of systemic lupus erythematosus. But the disease only developed with prolonged exposure to the sun.

Proton pump inhibitors and diabetes mellitus

In 2009, studies appeared that showed a decrease in glucose levels in patients with type II diabetes mellitus when taking Pantoprazole.

It is currently unknown whether other proton pump inhibitors cause this effect or whether this effect is unique to Pantoprazole.

What is the best proton pump inhibitor?

The effectiveness of proton pump inhibitors is the same. However, it is known that the effect occurs faster when taking Lansoprazole. It is suitable if PPIs are prescribed for a short period of time.

For diseases that require long-term use of proton pump inhibitors, for example, with GERD, it is recommended to take Pantoprazole.

This drug is the safest for long-term use. Pantoprazole is also suitable for patients who are taking several medications simultaneously to treat other diseases.

Conclusion

Proton pump inhibitors are drugs used to reduce the production of hydrochloric acid in the stomach. Drugs in this group block the activity of an enzyme that promotes the production of hydrochloric acid in the stomach.

Due to this, the secretion of HCl is reduced, the pathological effect of gastric juice on the mucous membrane of the stomach, esophagus (when gastric contents are thrown into the esophagus) and on the duodenum is reduced.

PPIs help to quickly relieve symptoms of ulcers, gastritis, GERD and, with a course of use, achieve long-term remission.

Medicines are contraindicated in late pregnancy, breastfeeding, low acidity of gastric juice, gastrointestinal tumors, osteoporosis, infection in the body, kidney and liver failure.

Side effects occur only with long-term use of the drugs. Also, the likelihood of developing unwanted reactions increases when large doses of the drug are used.

Continuous use of proton pump inhibitors increases the risk of gastrointestinal cancer, osteoporosis and fractures, iron deficiency and B12 deficiency anemia, infectious process, myocardial infarction, unstable angina, cardiac death, dementia.

Rabeprazole can cause a cutaneous form of systemic lupus erythematosus. Pantoprazole reduces the concentration of glucose in the blood of patients with type II diabetes mellitus.

For short-term use of PPIs, Lansoprazole is suitable, since it is the one that causes the most rapid effect.

Pantoprazole is considered the safest proton pump inhibitor. It is prescribed when long-term use of PPIs and simultaneous treatment with other drugs is necessary.

International name

Group affiliation

Dosage form

pharmachologic effect

Proton pump inhibitor, reduces acid production - inhibits the activity of H+/K+-ATPase in the parietal cells of the stomach and thereby blocks the final stage of HCl secretion. The drug is a prodrug and is activated in the acidic environment of the secretory tubules of parietal cells.

Reduces basal and stimulated secretion regardless of the nature of the stimulus. The antisecretory effect after taking 20 mg occurs within the first hour, maximum after 2 hours. Inhibition of 50% of maximum secretion lasts 24 hours.

A single dose per day provides rapid and effective suppression of daytime and nighttime gastric secretion, reaching its maximum after 4 days of treatment and disappearing by the end of 3-4 days after the end of administration. In patients with duodenal ulcer, 20 mg omeprazole maintains intragastric pH at 3 for 17 hours.

Indications

Peptic ulcer of the stomach and duodenum (including prevention of relapses), reflux esophagitis, hypersecretory conditions (Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract, polyendocrine adenomatosis, systemic mastocytosis); NSAID gastropathy.

Eradication of Helicobacter pylori in infected patients with gastric and duodenal ulcers (as part of combination therapy).

Contraindications

Side effects

From the digestive system: diarrhea or constipation, abdominal pain, nausea, vomiting, flatulence; in rare cases - increased activity of liver enzymes, taste disturbances; in some cases - dry mouth, stomatitis, in patients with previous severe liver disease - hepatitis (including jaundice), impaired liver function.

From the hematopoietic organs: in some cases – leukopenia, thrombocytopenia, agranulocytosis, pancytopenia.

From the nervous system: in patients with severe concomitant somatic diseases - dizziness, headache, agitation, depression, in patients with previous severe liver disease - encephalopathy.

From the musculoskeletal system: in some cases - arthralgia, myasthenia, myalgia.

From the skin: rarely - skin rash and/or itching, in some cases - photosensitivity, exudative erythema multiforme, alopecia.

Allergic reactions: urticaria, angioedema, fever, bronchospasm, interstitial nephritis and anaphylactic shock.

Other: rarely - gynecomastia, malaise, visual impairment, peripheral edema, increased sweating, formation of gastric glandular cysts during long-term treatment (a consequence of inhibition of HCl secretion, is benign, reversible).

Application and dosage

Orally, capsules are usually taken in the morning; capsules should not be chewed with a small amount of water (immediately before or during meals).

For exacerbation of peptic ulcer, reflux esophagitis and NSAID gastropathy - 20 mg 1 time per day. For patients with severe reflux esophagitis, the dose is increased to 40 mg once a day. The course of treatment for duodenal ulcer is 2-3 weeks, if necessary – 4-5 weeks; for gastric ulcers and esophagitis – 4-8 weeks.

Patients resistant to treatment with other antiulcer drugs are prescribed 40 mg/day. The course of treatment for duodenal ulcer is 4 weeks, for gastric ulcer and reflux esophagitis – 8 weeks.

For Zollinger-Ellison syndrome – 60 mg; if necessary, the dose is increased to 80-120 mg/day (in this case it is prescribed in 2-3 doses).

To prevent relapses of peptic ulcer – 10 mg 1 time per day.

To eradicate Helicobacter pylori, “triple” therapy is used (within 1 week: omeprazole 20 mg, amoxicillin 1 g, clarithromycin 500 mg - 2 times a day; or omeprazole 20 mg, clarithromycin 250 mg, metronidazole 400 mg - 2 times a day). day; either omeprazole 40 mg once a day, amoxicillin 500 mg and metronidazole 400 mg – 3 times a day) or “double” therapy (within 2 weeks: omeprazole 20-40 mg and amoxicillin 750 mg – 2 times a day) day or omeprazole 40 mg - once a day and clarithromycin 500 mg - 3 times a day or amoxicillin 0.75-1.5 g - 2 times a day). Special dosage regimen. For liver failure, 10-20 mg is prescribed; in case of impaired renal function and in elderly patients, no dosage adjustment is required.

special instructions

Before starting therapy, it is necessary to exclude the presence of a malignant process (especially with a stomach ulcer), because Treatment, masking symptoms, can delay the correct diagnosis.

Taking it with food does not affect its effectiveness.

Interaction

May reduce the absorption of ampicillin esters, iron salts, itraconazole and ketoconazole (omeprazole increases gastric pH).

Being inhibitors of cytochrome P450, it can increase the concentration and reduce the excretion of diazepam, indirect anticoagulants, phenytoin (drugs that are metabolized in the liver via cytochrome CYP2C19), which in some cases may require a reduction in the doses of these drugs.

At the same time, long-term use of omeprazole at a dose of 20 mg 1 time per day in combination with caffeine, theophylline, piroxicam, diclofenac, naproxen, metoprolol, propranolol, ethanol, cyclosporine, lidocaine, quinidine and estradiol did not lead to a change in their plasma concentrations.

Strengthens the inhibitory effect on the hematopoietic system of other drugs.

There was no interaction with concomitantly taken antacids.

Reviews about the drug Omeprazole: 0

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A modern and effective drug, omeprazole, reduces the level of gastric secretion and suppresses the release of pepsin. The first dose of the drug gives quick results, which explains its high popularity among patients.

Indications for the use of omeprazole include peptic ulcer of the duodenum, stomach, hypersecretion conditions, reflux esophagitis, gastropathy.

The drug is available in tablets, ampoules, and capsules. The active substance is similar to the name of the drug - omeprazole. The medicine is produced by a number of countries, including Russia, Belarus, India, as well as many European companies.

Prices for tablets from 20 rubles allow you not to look for cheap analogues of the drug, except in cases where there is an individual intolerance to the components in the medicine.

Russian-made analogues

The Russian pharmaceutical market offers its own drugs similar to omeprazole.

Close Russian-made substitutes are listed in the table:

Ukrainian substitutes

List of Ukrainian-made drugs that are analogues of omeprazole or its close substitutes:

1. Omeprazole Darnitsa. Price 25 rubles. The drug is used to treat gastroesophageal reflux disease. Antiulcer drug.
2. Esonexa. Price 75 rubles. The active ingredient is ezoneprazole. Available in capsules. Proton pump inhibitor.
3. Rabprazole Health. Price 95 rubles. Successfully treats active ulcers of the duodenum, stomach, erosive reflux disease, Zollinger-Ellison syndrome.

Belarusian generics

When choosing a substitute for omeprazole, pay attention to Belarusian generics, which are excellent in treating complex diseases. The price range for medications allows them to be an excellent replacement for a cheap drug.

A list of some Belarusian synonyms is given below:

• Omeprazole. The cheapest drug containing omeprazole. The medication is available in capsule form and is prescribed to adults and children strictly as prescribed by a doctor. During pregnancy, use is not recommended. Price – 30 rubles.
• Omeprazole Nika. Powder for the preparation of a solution for intravenous administration, with the active ingredient omeprazole. An antiulcer agent that effectively reduces stomach acidity. Available in powder form, in ampoules, in a bottle. Price – 75 rubles.

Other foreign analogues

Many countries produce imported drugs containing omeprazole in large quantities. The best synonyms differ in cost and dosage.

Let's consider cheaper products, as well as expensive modern medicines:

The instructions for the above-mentioned medications indicate that the effect of taking the medication occurs within two hours from the moment of use and lasts for 24 hours.

Single daily use normalizes the production of gastric juice and stabilizes the level of secretion. Omeprazole creates optimal conditions for the normal functioning of the gastrointestinal tract.

The drug is taken an hour before meals, washing down the capsule with a full glass of water. The course of treatment should not exceed four weeks. The drug guarantees the elimination of symptoms, but the cause of the disease must be established together with a doctor. Remember, self-prescription of medications is prohibited!

Related Posts

Drugs for the treatment of excess stomach acidity and peptic ulcers are very popular. Let's consider the most accessible and popular proton pump inhibitors (drugs of this class are usually called by the abbreviation PPI or PPI), which are based on the active substance omeprazole and rabeprazole (a slightly modified analogue of the first).

10 popular analogues of omeprazole and rabeprazole

1. Omez (omeprazole). The drug is made in India. Advantages: a variety of dosages, the presence of an injection form, which increases bioavailability, the cost is lower than other analogues, but higher than that of omeprazole. Disadvantages: the maximum concentration is reached over a long time, the half-life is short. The average price per package is about 170 rubles.
2. Ultop (omeprazole). Manufacturer: Russia or Slovenia. Advantages: different dosages, injection forms, high bioavailability, long half-life, relatively low cost (80-90 rubles). Disadvantages: long time to create maximum concentration.
3. Losec (omeprazole). Country Sweden. Advantages: injection form, maximum concentration is achieved in a short time. Disadvantages: high price among all analogues - 1800 rubles.
4. Gastrozole (omeprazole). Russia. It is characterized by high bioavailability, relatively low cost (100 rubles), and a variety of packaging (cans, blisters). Disadvantages: only one dosage, shortened half-life.
5. Orthanol (omeprazole). Slovenia. Advantages: long half-life, variety of dosages, average price (90-100 rubles). Disadvantages: maximum concentration is achieved over a long period of time.
6. Helicide (omeprazole). Czech Republic. The bioavailability of capsules is higher than their analogues, the availability of injection forms. The downside is the high price (260-290 rubles).
7. (rabeprazole). Switzerland, Japan, Belgium. The disadvantage is the high price (1000-1300 rubles).
8. Rabeloc (rabeprazole). India. Pros: form for intravenous administration (lyophilisate), providing high bioavailability. Cost from 300 rub.
9. Ontime (rabeprazole). Israel. It has the lowest bioavailability of all substitutes. Cost 500 rub.
10. Zolispan (rabeprazole). Spain. High bioavailability and half-life.