Cyclodinone purpose. Cyclodinone instructions for use, contraindications, side effects, reviews

Film-coated tablets - 1 tablet:

• active ingredients: dry extract of common twig fruit (Agnus castus) - 3.2-4.8 mg, which corresponds to 40 mg of medicinal plant material;
• excipients: povidone; colloidal silicon dioxide; potato starch; lactose monohydrate; MCC; magnesium stearate - shell composition: talc; titanium dioxide (IV) (E171); iron oxide yellow (E172); indigotine (E132); macrogol 6000; copolymer of methacrylic and ethacrylic acids.

There are 15 pcs in a blister; in a cardboard pack 2 (30 tablets) blister packs. Drops for oral administration - 100 g:

• dry extract of common twig fruit (Agnus castus) - 0.192-0.288 g, which corresponds to 2.4 g of medicinal plant material;
• excipients: povidone; sorbitol 70% (non-crystallizing); polysorbate 20; sodium saccharate dihydrate; peppermint flavoring; ethanol 96%; purified water.

In dark glass dropper bottles (with a dispensing device) 50 ml; 1 bottle in a cardboard pack.

Description of the dosage form

Drops for oral administration: transparent, yellow-brown liquid with the odor of the fruit of the common twig. Slight sediment may form during storage. Tablets: round, biconvex, greenish-blue in color with a matte surface.

Characteristic

Herbal product.

Pharmacodynamics

The components of the drug have a normalizing effect on the concentration of sex hormones. The main active component of the drug is common twig. The dopaminergic effects of the drug, causing a decrease in prolactin production, eliminate hyperprolactinemia. An increased concentration of prolactin disrupts the secretion of gonadotropins, which can result in disturbances in follicular maturation, ovulation and the formation of the corpus luteum, which further leads to an imbalance between estradiol and progesterone and can cause menstrual irregularities, as well as mastodynia. Unlike estrogens and other hormones, prolactin also has a direct stimulating effect on proliferative processes in the mammary glands, enhancing the formation of connective tissue and causing expansion of the milk ducts. A decrease in prolactin content leads to the reverse development of pathological processes in the mammary glands and relieves pain. The rhythmic production and normalization of the ratio of gonadotropic hormones leads to the normalization of the second phase of the menstrual cycle.

Indications for use Cyclodinone

Menstrual irregularities; premenstrual syndrome; mammalgia.

Contraindications to the use of Cyclodinone

Individual hypersensitivity to the components of the drug.

Cyclodinone Use during pregnancy and children

Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Cyclodinone Side effects

Rarely - allergic skin reactions. There is evidence of rare cases of transient psychomotor agitation, confusion and hallucinations.

Drug interactions

When combined with dopamine receptor antagonists, a mutual decrease in effect is possible. Interactions with other drugs are still unknown.

Dosage of Cyclodinone

Inside, 40 drops or 1 tablet. 1 time per day in the morning, with a small amount of water (the tablets are not chewed). Drops should be shaken before use. The duration of treatment is at least 3 months (without a break during menstruation). After the symptoms disappear and the condition improves, treatment should be continued for several weeks. If after completion of treatment complaints appear again, you should consult a doctor.

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The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!

Cyclodinone - composition and release forms

Pills Cyclodinone has a round, biconvex shape and is greenish-blue in color. The surface of the tablets is matte, without any shine. Drops Cyclodinone is a transparent solution, colored yellowish-brown and having a specific odor of twig fruit. During storage, a small amount of sediment may form in the solution, which is normal and does not indicate deterioration of the drug.

Cyclodinone drops and tablets contain the same active substance - common twig extract . One tablet contains 3.2 - 4.8 mg of dry extract, and 100 g of drops - 192 - 288 mg. Accordingly, 1 g of Cyclodinone drops contains 1.92 – 2.88 mg of active substance. And since a single dose of Cyclodinone for administration is 40 drops, which corresponds to approximately 2 g of solution, then we can say that the content of the active substance in a standard dose of solution is 3.84 - 5.76 mg. The standard single dosage for tablets is one piece per dose. That is, when taking tablets, a woman receives 3.2 - 4.8 mg of the active substance. Accordingly, when using drops, the single dosage of the active substance received by a woman is slightly higher compared to tablets.

Cyclodinone drops contain the following substances as auxiliary components:

• Povidone;
• Polysorbate 20;
• Sodium sucrose dihydrate;
• Peppermint flavoring;
• Ethyl alcohol 96%;

• Colloidal silicon dioxide;
• Potato starch;
• Lactose monohydrate;
• Microcrystalline cellulose;
• Magnesium stearate;
• Talc;
• Titanium dioxide;
• Iron oxide yellow;
• Indigotine;
• Macrogol 6000;
• Copolymer of methacrylic and ethacrylic acids.

Cyclodinone – photo

Therapeutic effect of the drug

So, dopamine in the pituitary gland and hypothalamus is an inhibitory transmitter, that is, it reduces the activity of these brain structures. And since the hypothalamus and pituitary gland produce hormones such as prolactin, somatotropin and somatotropin, dopamine, inhibiting the work of these brain structures, also reduces the synthesis of these gonadotropic hormonal substances. Accordingly, the higher the amount of dopamine in the pituitary gland and hypothalamus, the less prolactin, somatoliberin and somatotropin they can synthesize and release into the bloodstream. Due to this pharmacological effect, dopaminomimetics drugs can be used to treat various conditions associated with excessive secretion of prolactin, somatoliberin and somatotropin.

For women, the most sensitive and dangerous is excess secretion of prolactin, since large amounts of this hormone provoke various menstrual irregularities, PMS, periodic pain in the mammary glands, mastodynia (engorgement of the mammary glands) and fibrocystic mastopathy. In addition, excess prolactin increases the production of follicle-stimulating and luteinizing hormones, which, in turn, provoke disturbances in the formation of follicles, ovulation and the corpus luteum. In this case, women develop an imbalance between the concentrations of estrogen and progesterone and, accordingly, a wide variety of disorders of menstrual, sexual and reproductive functions. In addition, dopamine deficiency is associated with diseases such as constant amenorrhea, restless legs syndrome and involuntary movements of the limbs, depression, aggressiveness, etc.

Cyclodinone reduces the production of prolactin due to its ability to act on dopamine receptors, and normalizes the balance of estrogen and progesterone in a woman’s body. Accordingly, the drug normalizes the menstrual cycle, sexual and reproductive function, and also eliminates mastopathy, pain and engorgement of the mammary glands, relieves PMS and streamlines the course of the second half of the cycle. Elimination of mastopathy occurs due to the fact that Cyclodinone neutralizes the effect of prolactin, which stimulates proliferative processes in the breast.

Cyclodinone – hormonal or not?

Indications for use

• Menstrual irregularities associated with insufficiency of the corpus luteum (second half of the cycle);
• Mastodynia (engorgement, swelling and tenderness of the mammary glands);
• Mastalgia (pain in the mammary glands).

Instructions for use

Cyclodinone - instructions for use of tablets

Cyclodinone tablets should be taken for at least three months, without interruptions during periods of menstrual bleeding. After complete normalization of the condition, it is recommended to continue taking Cyclodinone for another 4 to 5 weeks in order to consolidate the therapeutic effect and maintain it for a long period of time.

If after completion of therapy the symptoms of the disease appear again, you should consult a doctor. If you develop weakness, depression, chest pain and menstrual irregularities while taking Cyclodinone tablets, you should immediately stop using the drug and consult a doctor.

The tablets contain small amounts of milk sugar, so they can be taken by women with diabetes. However, due to the presence of lactose, tablets can provoke transient pain in the stomach and diarrhea. If a woman develops such side effects from the digestive tract, then she should switch to taking Cyclodinone drops.

Cyclodinone drops - instructions for use

Add the required number of drops to a tablespoon or small container, such as a glass, then add clean water and drink. Drops in their pure form, not diluted with a small amount of water, can also be taken, but in this case they will have a specific taste of ethyl alcohol. To measure the required number of drops, hold the bottle strictly vertically, turning it upside down.

The drops should be taken continuously for at least three months, without taking breaks during periods of menstrual bleeding. After improvements in the condition appear, it is recommended to take the drug for at least another 4 to 5 weeks to consolidate the therapeutic effect.

If after finishing treatment the symptoms of the disease appear again, you should consult a doctor. If you experience weakness, depression, pain in the mammary glands, or menstrual irregularities while taking Cyclodinone drops, you should stop using the drug and consult a doctor.

Drops should not be taken by women who currently or have ever suffered from alcoholism in the past. And women suffering from diabetes can take Cyclodinone drops.

Dosages, frequency and duration of taking Cyclodinone for mastopathy, mastodynia, PMS and menstrual irregularities

The duration of therapy is at least three months of continuous use of the drug. Typically, Cyclodinone drops and tablets are recommended to be taken until the condition is completely normalized and painful symptoms disappear, plus another 4 to 5 weeks. An additional 4 to 5 weeks of taking the drug after the symptoms disappear are necessary to ensure that the effect is lasting and a relapse of the disease does not develop in the near future.

special instructions

Reviews of attempts to treat with Cyclodinone diagnoses made by ultrasound as “scleropolycystic ovaries” and “multifollicular ovaries” are mostly negative, since the condition of women most often worsened compared to the initial one. This situation arose because this category of patients did not have indications for taking Cyclodinone - they had a normal menstrual cycle with absence or minor pain during menstruation, etc. However, women suffering from polycystic ovary syndrome and taking Cyclodinone against the background of an irregular menstrual cycle in order to normalize it, left positive reviews about the drug, since it turned out to be very effective.

Reviews on the use of Cyclodinone when planning pregnancy

In addition, there are positive reviews about Cyclodinone, which was used to reduce the level of prolactin in the blood, which had been preventing pregnancy for several months against the background of seemingly complete health. In such situations, the drug successfully reduced the level of prolactin in the blood, and women successfully became pregnant.

However, there are also negative reviews about the use of Cyclodinone for the purpose of getting pregnant, which are associated with the ineffectiveness of the drug in this particular case.

Reviews from doctors

Trade name:

Cyclodinone®

International nonproprietary or generic name:

Common twig fruit extract

Dosage form:

film-coated tablets

Composition (per 1 tablet):

Active ingredient:

Common twig* fruit dry extract (7-11: 1, extractant – ethanol 70% by volume) - 4.00 mg

Excipients: povidone K 30, colloidal silicon dioxide, potato starch, lactose monohydrate, microcrystalline cellulose, magnesium stearate, talc, titanium dioxide (E 171), yellow iron oxide dye (E 172), indigo carmine aluminum varnish (E 132), macrogol 6000, ammonium methacrylate copolymer (type A)

* Latin name –Vitexagnus-castusL.

Description

Round, biconvex, film-coated tablets, greenish-blue in color with a matte surface.

Pharmacotherapeutic group

Drugs for the treatment of gynecological diseases

ATX code: G02CX03

pharmachologic effect

The components of the drug have a normalizing effect on the concentration of sex hormones.

The main active component of the drug is common twig. The dopaminergic effects of the drug, causing a decrease in prolactin production, eliminate hyperprolactinemia. An increased concentration of prolactin disrupts the secretion of gonadotropins, which can result in disturbances in follicular maturation, ovulation and the formation of the corpus luteum, which further leads to an imbalance between estradiol and progesterone and can cause menstrual irregularities, as well as mastodynia. Unlike estrogens and other hormones, prolactin also has a direct stimulating effect on proliferative processes in the mammary glands, enhancing the formation of connective tissue and causing expansion of the milk ducts. A decrease in prolactin concentration leads to the reverse development of pathological processes in the mammary glands and relieves pain. The rhythmic production and normalization of the ratio of gonadotropic hormones leads to the normalization of the second phase of the menstrual cycle.

Indications for use

Menstrual irregularities, premenstrual syndrome, mastodynia.
Before starting to use the drug, you should consult your doctor.

Contraindications

Individual hypersensitivity to the components of the drug, lactose intolerance, lactase deficiency, glucose-galactose malabsorption (due to lactose content in the drug), breast cancer, pituitary tumors, age under 18 years (there are no data on the effectiveness and safety of the drug in this age group ); pregnancy and breastfeeding period.

Carefully

Precautionary measures must be taken if patients have a history of estrogen-dependent malignant neoplasms and pituitary diseases. Before starting to use the drug, you should consult your doctor.

Use during pregnancy and breastfeeding

The drug is not used during pregnancy and breastfeeding.

As the regularity of the menstrual cycle increases while taking the drug, the likelihood of pregnancy increases. If pregnancy occurs, the drug should be discontinued.

Directions for use and doses

Take 1 tablet orally 1 time per day in the morning, without chewing, with a sufficient amount of water - 100-200 ml. The duration of treatment is at least 3 months (without a break during menstruation). Use of the drug for more than 3 months should be discussed with your doctor. If symptoms of the disease persist while using the drug, you should consult a doctor. If after completion of treatment complaints reappear, you should consult your doctor.

The drug should not be used to treat children and adolescents under the age of 18 years.

Side effect

Severe allergic reactions with facial swelling, shortness of breath and dysphagia are possible. Allergic reactions from the skin (rash, urticaria), gastrointestinal disorders (pain in the epigastric region, nausea), headache, dizziness, acne, menstrual irregularities may occur. The frequency of adverse reactions is unknown, i.e. cannot be estimated based on the available data. If the above-described adverse reactions or other adverse reactions not listed in the instructions occur, you should stop taking the drug and consult a doctor.

Overdose

No cases of overdose have been registered. In case of overdose, the severity of dose-dependent side effects may increase. Treatment is symptomatic.

Interaction with other drugs

A mutual decrease in effectiveness is possible when taking dopamine receptor antagonists simultaneously, as well as interaction with dopamine receptor agonists, estrogens and antiestrogens. If you are taking such medications, you should consult your doctor before you start taking Cyclodinone®.

Interaction with other drugs is currently unknown.

special instructions

Instructions for patients with diabetes: the carbohydrates included in 1 tablet of the drug are less than 0.03 “bread units” (XU).

If you currently have or have a history of malignant estrogen-dependent tumors, or have a history of pituitary gland diseases, a doctor’s consultation is required.

The possibility of masking the clinical manifestations of a pituitary tumor secreting prolactin while taking the drug should be taken into account.

List of conditions requiring medical consultation: if you feel tension and swelling of the mammary glands and/or weakness, depression, as well as menstrual irregularities, you should consult a doctor for additional examination.

In order to monitor the effectiveness of the treatment, a monthly consultation with a doctor is recommended.

Impact on the ability to drive vehicles and machinery

When used in recommended doses, the drug does not affect the ability to perform potentially hazardous activities that require increased concentration and speed of psychomotor reactions (driving vehicles, working with moving mechanisms, working as a dispatcher and operator).

Release form

Film-coated tablets. 15 tablets in a blister made of aluminum foil and PVC/PVDC film. 2 or 4 blisters are placed together with instructions for use in a cardboard pack.

Storage conditions

Active substance

Common twig fruit extract (Extractum fructuum Agni casti)

ATX:

Pharmacological group

Nosological classification (ICD-10)

Compound

Description of the dosage form

Pills: round, biconvex, greenish-blue in color with a matte surface.

Drops for oral administration: transparent, yellow-brown liquid with the smell of common twig fruit. Slight sediment may form during storage.

pharmachologic effect

pharmachologic effect- dopaminomimetic .

Pharmacodynamics

The components of the drug have a normalizing effect on the concentration of sex hormones.

The main active component of the drug is common twig. The dopaminergic effects of the drug, causing a decrease in prolactin production, eliminate hyperprolactinemia. An increased concentration of prolactin disrupts the secretion of gonadotropins, which can result in disturbances in follicular maturation, ovulation and the formation of the corpus luteum, which further leads to an imbalance between estradiol and progesterone and can cause menstrual irregularities, as well as mastodynia. Unlike estrogens and other hormones, prolactin also has a direct stimulating effect on proliferative processes in the mammary glands, enhancing the formation of connective tissue and causing expansion of the milk ducts. A decrease in prolactin content leads to the reverse development of pathological processes in the mammary glands and relieves pain. The rhythmic production and normalization of the ratio of gonadotropic hormones leads to the normalization of the second phase of the menstrual cycle.

Indications of the drug

menstrual irregularities;

premenstrual syndrome;

mammalgia.

Contraindications

Individual hypersensitivity to the components of the drug.

Use during pregnancy and breastfeeding

The drug should not be used during pregnancy or during breastfeeding.

Side effects

Rarely - allergic skin reactions. There is evidence of rare cases of transient psychomotor agitation, confusion and hallucinations.

Interaction

When combined with dopamine receptor antagonists, a mutual decrease in effect is possible. Interactions with other drugs are still unknown.

Directions for use and doses

Inside.

Take 40 drops or 1 tablet. 1 time per day in the morning, with a small amount of water (the tablets are not chewed). Drops should be shaken before use.

The duration of treatment is at least 3 months (without a break during menstruation). After the symptoms disappear and the condition improves, treatment should be continued for several weeks. If after completion of treatment complaints appear again, you should consult a doctor.

Overdose

Cases of overdose are unknown.

special instructions

If you develop weakness, depression, pain in the mammary glands, as well as in the case of menstrual irregularities, it is recommended to consult a doctor.

Cyclodinone is a herbal remedy that has a dopaminomimetic effect.

This drug is capable of bringing the concentration of sex hormones to normal levels. Its properties are due to the action of common twig, the main active component of the drug.

The use of Cyclodinone normalizes prolactin levels, so proliferative processes begin to occur more actively in the mammary gland, which leads to an increase in the formation of connective tissues and expansion of the milk ducts. Thanks to the use of the drug in the mammary glands, pain syndromes are also relieved, and pathological processes reverse development.

Clinical and pharmacological group

A herbal medicine used for menstrual irregularities, mastodynia and premenstrual syndrome.

Terms of sale from pharmacies

Can buy according to a doctor's prescription.

Price

How much does Cyclodinone cost in pharmacies? The average price is 500 rubles.

Composition and release form

Cyclodinone is available in several dosage forms: tablets for oral administration and drops for oral use.

• 100 grams of Cyclodinone drops include 193-288 mg of dry extract of common twig. Additional substances: polysorbate 20, 70% sorbitol, povidone, mint flavor, water, sodium sucrose dihydrate, 96% ethanol.
• 1 tablet of Cyclodinone contains 3.3-4.8 mg of dry extract of common twig. Additional substances: microcrystalline cellulose, indigotine, silicon dioxide, povidone, lactose monohydrate, starch, magnesium stearate, titanium dioxide, talc, iron oxide, macrogol 6000, emethacrylic acid copolymer, ethacrylic acid copolymer.

Pharmacological effect

Cyclodinone normalizes the level of concentration of sex hormones in a woman’s body. The active component of Cyclodinone is a dry extract of the fruit of the common twig.

The drug has a dopaminergic effect, which leads to a decrease in prolactin production in the body. An increased level of prolactin leads to disruption of ovulation and the formation of the corpus luteum, so a woman may experience a disruption in her menstrual cycle and experience mastodynia.

Prolactin can also cause the formation of connective tissue and dilation of the milk ducts, which leads to pathology in the mammary glands. The use of Cyclodinone reduces prolactin levels, thereby reducing pain syndromes in the mammary glands and reversing the development of pathological processes.

Indications for use

The drug Cyclodinone in the form of tablets and drops is prescribed for oral administration for the treatment and correction of the following conditions:

• , manifested by mood swings, tearfulness, aggression, apathy, breast tenderness, bloating, increased appetite;
• menstrual disorders of various origins as part of complex therapy;
• mastopathy.

Contraindications

Contraindications to the use of the drug in therapeutic practice include the presence of intolerance in the patient to any of the components of the drug. Also, the medicine is not used in children, pregnant women and women during the lactation period.

Prescription during pregnancy and lactation

Since Cyclodinone normalizes a woman’s menstrual cycle, stimulates follicle maturation and ovulation, its use increases the likelihood of pregnancy. In addition, Cyclodinone reduces the level of prolactin in the blood, which can cause infertility in the absence of other diseases, and thereby also promotes pregnancy. Therefore, this drug is often prescribed to girls who cannot get pregnant despite seemingly being in perfect health. And, according to reviews of this category of women, within a short period of time (from 1 to 6 months) of taking Cyclodinone, they experienced a desired pregnancy.

In addition, Cyclodinone is prescribed to women after preliminary blood tests for hormones, if an increase in prolactin has been detected. In this case, the drug also normalized hormone levels and led to the desired pregnancy within a maximum of one year.

From the above it follows that Cyclodinone is an excellent remedy as part of comprehensive preparation for pregnancy, since it normalizes the menstrual cycle and maximizes the onset of conception in the shortest possible time.

When planning pregnancy, doctors recommend taking Cyclodinone 1 tablet or 40 drops once a day for three months, in combination with vitamins and iodine. If necessary, the drug can be taken for longer than three months. Then Cyclodinone is discontinued and they begin to actively try to get pregnant. If pregnancy occurs accidentally while using Cyclodinone, then it is not necessary to interrupt it, since observations of such cases have not revealed any negative consequences from the effects of the drug. However, Cyclodinone is not recommended for use during pregnancy and breastfeeding.

Dosage and method of administration

As indicated in the instructions for use, Cyclodinone is taken orally, 1 tablet. 1 time/day, in the morning, without chewing, with a small amount of water.

Treatment is carried out for 3 months, without interruption during menstruation. After the symptoms disappear and the condition improves, treatment should be continued for several weeks.

If complaints reappear after discontinuation of the drug, you should consult your doctor.

Adverse reactions

Reviews of Cyclodinone confirm that the drug is well tolerated.

Some patients experience minor allergic reactions, and rare cases of hallucinations and confusion are known during the use of Cyclodinone.

Overdose symptoms

No cases of overdose with Cyclodinone have been identified, however, when using this medication, the recommended dosages should be strictly observed.

special instructions

Film-coated tablets contain milk sugar (lactose).

Lactose intolerance may be considered a possible cause of epigastric pain and diarrhea.

If you experience pain in the mammary glands and/or weakness, depression while taking the drug, as well as menstrual irregularities, it is recommended to consult a doctor.

Compatibility with other drugs

Interaction with other drugs is still unknown.

In patients taking dopamine receptor antagonists, a mutual weakening of the effect of the drugs is possible.