Instructions for the use of trimecaine, indications and side effects, analogues. Trimecain

2 ml - ampoules (10) - packs of cardboard.

pharmachologic effect

local anesthetic. Causes fast-onset prolonged conduction, infiltration, epidural, spinal anesthesia. The mechanism of action is due to the stabilization of neuronal membranes and the prevention of the occurrence and conduction of a nerve impulse. It has a more intense and long-lasting effect than procaine. Low toxicity, does not cause local tissue irritation.

It has an antiarrhythmic effect, belongs to the IB class. Experimental studies have shown that its antiarrhythmic effect is 1.5 times stronger than that of. However, with ventricular extrasystoles in patients with acute myocardial infarction, it is less effective than lidocaine.

Pharmacokinetics

With intravenous administration, T 1/2 in the α-phase is about 8.3 minutes, in the β-phase - about 168 minutes.

Indications

Conduction, infiltration, epidural and spinal anesthesia.

Ventricular arrhythmias in acute, ventricular arrhythmias (independent of the concentration of potassium in the blood) with intoxication with digitalis preparations, ventricular tachycardia, arrhythmias during surgical interventions and cardiac catheterization.

Contraindications

Hypersensitivity to trimekain.

Dosage

Individual, depending on the type of anesthesia, indications.

Side effects

From the side of the central nervous system: headache, dizziness.

Allergic reactions: urticaria, anaphylactic shock.

Others: pallor of the skin of the face, nausea.

drug interaction

Which is often used in combination with trimecaine, causes local vasoconstriction, which leads to a slowdown in the absorption of trimecaine, providing an increase and prolongation of its anesthetic effect, and a decrease in systemic action.

Trimecaine is used as a local anesthetic for infiltration, conduction anesthesia in dentistry.

Dental patients have a strong psycho-emotional attitude to pain at the thought of dental treatment. When choosing an anesthetic, the following factors are taken into account:

• Determine the patient's risk group
• The presence of hereditary, chronic diseases
• Age category

Produced in the form of a white powder with a yellowish tinge and a 2% solution in 2 ml ampoules. Possesses high resistance to influence of an acidic environment.

Good lipophilicity promotes the penetration of the anesthetic through the sheath of nerve fibers. By binding to receptors, it slows down the process of depolarization, the threshold of myocardial excitability increases. The resting potential lengthens.

The refractory (short-term) period of disappearance of the excitability of nerve and muscle tissues is prolonged after their response to the stimulus. Stops digitalis toxic arrhythmia. It has a depressing effect on the cerebral cortex.

Antiarrhythmic indicators are 1.5 times higher than the properties of lidocaine. Efficiency is reduced if the patient has ventricular extrasystole in acute myocardial infarction.

The anesthetic activity of trimecaine is higher, it occurs faster than that of novocaine. The half-life is 1.5 hours. It has a vasodilating effect, it is used simultaneously with vasoconstrictors (vasoconstrictor drugs).

It has a mild anticonvulsant, hypnotic and sedative effect.

Appointment and doses of the drug

Trimecaine is indicated for the following dental interventions:

• Carrying out some types of tooth-preserving operations
• Prosthetics
• Implantation
• Direct and indirect restoration of teeth

Infiltration anesthesia - p - p 0.125%, 0.25%, 0.5%. Quantity - 1500-400 ml

Conductor - r - r 1-2% 20-100 ml

As a vasoconstrictor, adrenaline solution 0.1% is mainly used.

Precautionary measures

Trimecaine is not prescribed if the patient has peripheral vascular disease, arterial hypertension.

The use of anesthetic in childhood:

4-8 ml 1% r - r, 2-4 ml 2% r - r (2-5) years

10-20 ml 1% and 5-10 ml 2% r - r (6-11) years

Contraindications for use

• Damage to the circulatory system - atherosclerosis
• Heart disease - insufficiency, atrioventricular block
• Individual intolerance
• Diseases of the kidneys, liver
• Pregnancy

Due to the increased incidence of local reactions, this anesthetic is replaced by more effective drugs.

International name:

Dosage form:

Pharmachologic effect:

Indications:

Dioxysol

International name: Hydroxymethylquinoxylindioxide + Trimecaine (Hydroxymethylquinoxylindioxide + Trimecaine)

Dosage form: aerosol for local and external use, solution for external use

Pharmachologic effect: It has an antibacterial, local anesthetic and anti-burn effect, stimulates regeneration processes. Eliminates wound and perifocal...

Indications: Infected soft tissue wounds, abscesses, fistulas, trophic ulcers, bedsores; burns II-IV Art. (superficial and deep); in surgery, traumatology, ...

Dioxicol

International name: Hydroxymethylquinoxylindioxide + Trimecaine + Methyluracil (Hydroxymethylquinoxylindioxide + Trimecaine + Methyluracil)

Dosage form: topical ointment, topical powder

Pharmachologic effect: Combined broad-spectrum antibacterial drug. Active against Staphylococcus spp., Streptococcus spp., Proteus spp., ...

Indications: Fresh, infected and non-healing wounds; ulceration of the skin of various origins; osteomyelitis. Purulent wounds in the first (purulent-necrotic) phase of the wound process (ointment).

Catacel A

International name: Benzalkonium chloride + Trimecaine (Benzalkonium chloride + Trimecaine)

Dosage form: paste for external use

Pharmachologic effect: Benzalkonium chloride is an antiseptic that affects gram-positive and gram-negative bacteria, incl. Staphylococcus spp., ...

Indications: Burns (superficial, thermal), sluggish granulating wounds of soft tissues; trophic ulcers; infections against the background of diabetes mellitus; acute purulent paraproctitis; infected wounds.

Levosin

International name: Chloramphenicol + Methyluracil + Sulfadimethoxine + Trimecaine (Chloramphenicol + Methyluracil + Sulfadimethoxine + Trimecaine)

Dosage form: ointment for external use

Pharmachologic effect: Levosin is a combined drug that has antimicrobial, anti-inflammatory, analgesic and necrolytic effects.

Indications: Purulent wounds in the first phase of the wound process.

Trimecain

International name: Trimecain (Trimecaine)

Dosage form: injection

Pharmachologic effect: Local anesthetic, has an antiarrhythmic effect. Causes a rapidly onset prolonged superficial, conductive, ...

Indications: Superficial, infiltration, conduction, epidural and spinal anesthesia; ventricular extrasystole, paroxysmal ventricular...

Trimecaine with norepinephrine

International name: Trimecaine + Norepinephrine (Trimecaine + Norepinephrine)

Dosage form: injection

Pharmachologic effect: Trimekain with norepinephrine is a combined drug, the action of which is due to its constituent components; Provides local anesthetic...

Indications: Conduction or epidural anesthesia. As an anesthetic drug in maxillofacial surgery and therapeutic dentistry when removing...

local anesthetic. Causes fast-onset prolonged conduction, infiltration, epidural, spinal anesthesia. The mechanism of action is due to the stabilization of neuronal membranes and the prevention of the occurrence and conduction of a nerve impulse. It has a more intense and long-lasting effect than procaine. Low toxicity, does not cause local tissue irritation.
It has an antiarrhythmic effect, belongs to the IB class. Experimental studies have shown that its antiarrhythmic effect is 1.5 times stronger than that of lidocaine. However, with ventricular extrasystoles in patients with acute myocardial infarction, it is less effective than lidocaine.

Pharmacokinetics

With intravenous administration, T 1/2 in the α-phase is about 8.3 minutes, in the β-phase - about 168 minutes.

Indications for use

Conduction, infiltration, epidural and spinal anesthesia.
Ventricular arrhythmias in acute myocardial infarction, ventricular arrhythmias (independent of the concentration of potassium in the blood) with digitalis intoxication, ventricular tachycardia, arrhythmias during surgical interventions and cardiac catheterization.

Dosing regimen

Individual, depending on the type of anesthesia, indications.

Side effect

From the side of the central nervous system: headache, dizziness.
Allergic reactions: urticaria, anaphylactic shock.
Others: pallor of the skin of the face, nausea.

Contraindications for use

Hypersensitivity to trimekain.

Use during pregnancy and lactation

The safety of using trimecaine during pregnancy and lactation (breastfeeding) has not been established.

Application for violations of liver function

special instructions

Trimecaine (like other local anesthetics) in combination with vasoconstrictors is not used in patients with arterial hypertension, peripheral vascular disease, and also for anesthesia of tissues supplied by the terminal arteries (terminal phalanges, penis).
Trimecaine is not recommended for use in patients with impaired liver metabolism, with heart failure.

drug interaction

Norepinephrine, which is often used in combination with trimecaine, causes local vasoconstriction, which leads to a slowdown in the absorption of trimecaine, providing an increase and prolongation of its anesthetic effect, and a decrease in systemic action.