Isoprinosine for HPV treatment regimen. Isoprinosine for human papillomavirus

The site provides reference information for informational purposes only. Diagnosis and treatment of diseases should be carried out under the supervision of a specialist. All drugs have contraindications. Expert advice is required!

Composition, dosage forms and names of Isoprinosine

As auxiliary components, Isoprinosine tablets contain the following substances:

• Mannitol;
• wheat starch;
• magnesium stearate.

In everyday speech, names with qualifications are often used to refer to this drug, such as Isoprinosine 500, Isoprinosine 50, Isoprinosine 30 etc. In these names, the number 500 means the dosage of the active ingredient of the drug. And the numbers 30 and 50 mean the number of tablets in the package. Such designations allow doctors, pharmacists and patients to quickly understand exactly how many tablets are needed.

Therapeutic action

Stimulation of the immune system by Isoprinosine occurs due to the activation of the production of interleukins 1 and 2, as well as interferon gamma, which have anti-inflammatory activity. In addition, the production of interleukins 4 and 10 decreases, which, on the contrary, support and increase inflammation in various organs and tissues. As a result of such modulation of the production of interleukins and interferon, the intensity of the inflammatory process in any tissue or organ decreases, as a result of which the lesion decreases and the normal structure of cells is restored.

In addition, Isoprinosine activates the work of cytotoxic T-lymphocytes and natural killer cells (NK cells), which destroy cells damaged by viruses, which also leads to a decrease in the size of the inflammatory focus and restoration of the structure of an organ or tissue. In parallel with the increase in the activity of cytotoxic T-lymphocytes and NK cells under the influence of Isoprinosine, there is an increase in the production of T-suppressors and T-helpers, which, as it were, help other cells of the immune system "recognize" and destroy viruses or cellular structures affected by them. Separately, it should be canceled that under the action of Isoprinosine, the production of IgG class antibodies increases, which also contribute to the destruction of virus-infected cells.

All of the above components of activation of the immune system (an increase in the activity of cytotoxic T-lymphocytes, NK cells, T-helpers, T-suppressors, as well as the production of IgG, interleukins 1 and 2 and interferon gamma), aimed at the destruction of viruses, are implemented in the systemic blood flow. That is, all these cells and substances end up in the blood that flows to the affected organ or tissue. And when the blood flow delivers all the listed cells and substances to the required area, they are released and penetrate into the thickness of the tissues, where they have their effect.

In addition to the reactions of activation of the immune system, implemented in the bloodstream, there are other processes that occur directly in the thickness of the affected tissues or on the mucous membranes. The reactions of the immune system in the thickness of the tissues and on the mucous membranes are called local immunity, and represent a very important link in the general mechanism for the destruction of viruses and cells affected by them. After all, local immunity destroys viruses and affected cells constantly, without waiting for a massive reaction in the systemic circulation and, thereby, prevents pathogenic microorganisms from quickly infecting a large area of ​​tissue or organ. Under the action of Isoprinosine, local immunity is activated, which is manifested by the accumulation of a large number of monocytes, macrophages and neutrophils in the affected area of ​​​​the organ, which destroy cells infected with viruses.

The direct effect of Isoprinosine on viruses is that the drug inhibits their reproduction by blocking the work of the enzyme dihydropteroate synthetase. In laboratory experiments Isoprinosine successfully inhibits the reproduction of the following viruses:

• Herpes simplex 1 and 2 types;
• Cytomegalovirus;
• measles virus;
• Human T-cell lymphoma virus type III;
• Polioviruses;
• Influenza viruses types A and B;
• ECHO virus (human enterocytopathogenic virus);
• encephalomyelocarditis virus;
• Equine encephalitis virus.

Indications for use

• Influenza and other SARS;
• Herpetic infections caused by Herpes simplex viruses types 1, 2, 3 and 4 (labial and genital herpes, herpes keratitis);
• Herpetic infections caused by the Varicella zoster virus - chicken pox and shingles;
• Cytomegalovirus infection;
• Epstein-Barr virus infections (infectious mononucleosis);
• Papillomavirus infection in various manifestations, such as papillomas of the larynx, vocal cords, genital organs in men and women, as well as genital warts and warts of any localization;
• Molluscum contagiosum;
• Measles.

Isoprinosine - instructions for use

Dosage calculation for children and adults

• - the dosage is calculated individually according to body weight, based on the ratio of 50 mg per 1 kg of body weight per day. That is, if the body weight of an adult is 70 kg, then the daily dosage of Isoprinosine for him is 70 * 50 = 3500 mg, which corresponds to 7 tablets (3500/500). This calculated number of tablets is divided into 3-4 doses per day. Adults may not calculate the dosage of Isoprinosine individually, focusing on the fact that the average daily dose of Isoprinosine for a person with normal body weight (60-80 kg) is 6-8 tablets. In addition, you can use a simplified version of the calculation of the daily dosage of Isoprinosine - 1 tablet for every 10 kg of weight.
• Children 3 – 11 years old- the dosage is calculated individually according to body weight, based on the ratio of one tablet for every 10 kg of body weight per day. That is, if the child's body weight is 35 kg, then he should take 3.5 Isoprinosine tablets per day. The total daily amount of the drug for children is divided into 3-4 doses.

For children aged 3-11 years, the maximum daily dosage of Isoprinosine should not exceed the ratio of 50 mg per 1 kg of body weight, regardless of the severity of the disease. For example, if a child weighs 20 kg, then he needs to take 2 tablets per day, which is 1000 mg. To check if this dosage does not exceed the maximum allowable, you should divide it by the child's body weight - in our example 1000/20 = 50. Then the resulting figure must be compared with 50, and if it is less, then this means that the dosage is lower than the maximum allowable norms. If the resulting figure is more than 50, then the dosage of Isoprinosine is more than the maximum allowable rate for the child. In this case, the dosage should be reduced. In our example, the calculated dosage is equal to the maximum allowable for the child, so it can be used.

Elderly people (over 65 years of age) should take Isoprinosine at the usual adult dosages, without reducing them.

The duration of the use of Isoprinosine in individually calculated dosages is entirely determined by the type of disease.

Reception for acute SARS, influenza, measles, molluscum contagiosum and infectious mononucleosis

Reception in chronic diseases with recurring exacerbations (genital and labial herpes, shingles, infection caused by cytomegalovirus)

In addition, it is possible to use another treatment regimen, which consists in taking Isoprinosine in an age-specific individual dosage up to the complete disappearance of symptoms of an exacerbation of the disease. Then the drug should continue to be taken at the same dosage for another two weeks, which is necessary to achieve a stable remission.

Reception for any herpes infection (chicken pox, herpes keratitis, genital or labial herpes, shingles)

Reception for papillomas of any localization, papillomavirus infection or genital warts

• Adults and teenagers over 12 years old - Take 2 tablets 3 times a day.
• Children 3 – 11 years old- the daily dosage of Isoprinosine is calculated individually according to the ratio: one tablet for every 10 kg of the child's weight. The calculated total dosage of the drug is divided into 3-4 doses per day and given to the child for 14-28 days.

Isoprinosine for HPV

Use during pregnancy and breastfeeding

special instructions

With long-term use of Isoprinosine, the cellular composition of peripheral blood should be monitored every 4 weeks by counting the leukoformula as part of a general blood test, as well as monitoring the functioning of the liver and kidneys, determining the activity of AST and ALT, as well as the concentration of creatinine and uric acid in the blood.

In addition, it is necessary to frequently (at least once a week) monitor the concentration of uric acid in the blood when Isoprinosine is used simultaneously with drugs that impair kidney function or contribute to the accumulation of uric acid.

Influence on the ability to control mechanisms

Overdose

Interaction with other drugs

Drugs from the groups of xanthine oxidase inhibitors (for example, Allopurinol, Zilorik, Milurit, Purinol, Allopin, etc.) and uricosuric agents (salicylates, including Aspirin, Probenecid, Benemid, Sulfinpyrazone, diuretics, etc.) increase the risk of increasing urinary concentration acid in the blood and the development of gout.

With the simultaneous use of Isoprinosine with Acyclovir and Zidovudine, the antiviral effect of the latter is enhanced.

Isoprinosine for children

As a rule, the drug is used for children to treat acute viral infections (SARS, influenza, measles, chickenpox, molluscum contagiosum, infectious mononucleosis) or recurrent diseases associated with the herpes virus (for example, herpes on the lip, etc.). In general, it is recommended to give the child Isoprinosine for 5 to 15 days, depending on the severity of the infection and the speed at which symptoms disappear. In this case, it is necessary to use the rule that for acute diseases, Isoprinosine should be taken additionally within two days after the symptoms disappear, and for chronic recurrent infections, this should be done within two weeks after the relief of the exacerbation. In addition, after stopping the recurrence of a chronic infection, Isoprinosine can be given to a child 1 tablet per day for 30 days, and not in full dosage for two weeks.

Isoprinosine has been used for HPV for a long time, since about the 70s of the last century. Such a long practice of the drug in the fight against human papillomavirus infection is explained by its effectiveness and relative harmlessness when compared with other medicines.

Among the many drugs used in the treatment of HPV, the drug is not just one of the leading positions. Isoprinosine is one of the few drugs that have passed full-fledged clinical trials. The drug has fully confirmed its effectiveness.

Description of Isoprinosine

To date, the drug is presented only in tablet format. Its therapeutic effect is based on slowing down the reaction of DNA and RNA production in the nucleus of a viral cell. In addition, Isoprinosine is a good immunostimulant.

Against the background of taking the drug, the production of endogenous cytoleukins and human interferon is activated. It is this action that determines the properties of the drug:

• antiviral;
• anti-inflammatory;
• immunostimulating.

The tool is widely used in the treatment of acute forms of HPV. It affects not only the changed cells, but also the virus itself.

Isoprinosine enhances systemic immunity, and also activates local immune defenses. This means that its intake has a direct effect on the epithelium affected by the virus.

The dual effect of Isoprinosine - immunostimulating and antiviral - allows the use of the drug in the fight against many HPV genotypes, including highly carcinogenic ones.

The drug is rapidly absorbed by the mucosa of the intestinal tract. The maximum drug in the blood is determined one and a half hours after administration. Isoprinosine is excreted through the kidneys along with urine. It does not have a cumulative effect: it is completely eliminated after 2 days.

Methods of application and dosage

Isoprinosine is recommended for various types of warts, including genital warts and papillomatosis. The dosage of the drug is individual in each case and depends on the age group of the patient:

• for adolescents from 12 years old and the adult category of patients, it is recommended to take Isoprinosine three times a day. The dose of the drug depends on the weight of the patient. We drink the tablet as a whole, without crushing and drinking plenty of clean water;
• for children three to eleven years old, the selected dose is divided into three to four doses.

Dose calculation

The dosage of the drug for an adult is calculated based on the weight of the patient: 50 mg of Isoprinosine per 1 kg of body weight or one tablet for every ten kilograms of weight.

As a rule, the individual dosage is not calculated. The average daily dose for a person with a normal weight of 60-80 kg is six to eight pills. But in childhood (3 - 11 years), the dose is calculated necessarily. For every ten kilograms of weight, one tablet is taken. The resulting norm is necessarily divided into several doses (most often a four-time intake is recommended).

In severe HPV, the dosage calculation is performed somewhat differently. In this case, 100 mg of the drug or two pills for every ten kilograms of body weight should be taken per 1 kg of adult weight. For children, the allowable daily dose of the drug should not exceed 50 mg per 1 kg of body weight, regardless of the severity of papillomavirus infection.

Elderly patients - over 65 years of age - should take Isoprinosine at the standard dosage intended for adults. The duration of treatment depends on the type of disease, i.e. how long to drink Isoprinosine is decided by the attending physician.

Therapy with Isoprinosine

Identified papillomas of any localization, as well as genital warts (genital warts) require a fairly long time to take the drug - 14-28 days. In this case, warts found on the genitals are subject to mandatory removal.

The dosage of the drug depends on the age of the patient. Children over 12 years of age and adults are most often prescribed 2 tablets three times a day. Children under 11 years of age should receive a dose of the drug, calculated on the basis of the child's weight: for 10 kg of body weight, we take 1 tablet of Isoprinosine.

The received dose should be divided into three to four doses. The duration of treatment is 14 - 28 days. With the human papillomavirus, which is manifested by the formation of only skin warts, one course of taking the drug is enough.

But when genital warts are detected, the patient is recommended to conduct two courses. The first - after the removal of neoplasms, the second - a month after the completion of the first. When diagnosing cervical dysplasia, the following therapeutic regimen is used:

• within 10 days, a woman needs to take 2 tablets of the drug three times a day;
• then you need to take a two-week break and repeat the treatment.

In total, two or three courses are required. Isoprinosine gives positive results in about 90% of all cases. According to statistics, it is in this percentage of patients who took the drug at the recommended dosage that histological studies of the epithelium of the cervical canal show a complete absence of viral load. Recurrence of the disease during the first six months was recorded only in 3% of patients.

Alcohol compatibility

During treatment with Isoprinosine, it is necessary to completely abandon the use of alcoholic beverages. There are several reasons for this:

• ethanol several times enhances the side effects that occur. If the drug and alcohol are taken together, the risk of developing an allergic reaction, an attack of renal colic, renal failure, inflammation of the kidneys (pyelonephritis), and heart disorders increases significantly;
• the drug has a very negative effect on the liver, and in combination with alcohol, the organ is subjected to an even greater load. The tandem of Isoprinosine and alcoholic beverages is more than a toxic combination and can provoke jaundice, bile stasis (cholestasis), hepatitis and other disorders in the body;
• against the background of taking the medication in the body of a sick person, the process of producing its own interferons is activated, which enhances the negative effect of alcohol on the human body as a whole. Against the background of simultaneous treatment and alcohol intake, the patient may develop depressive states, thoughts of suicide may arise. In addition, disturbances of the peripheral nervous system are not excluded - numbness of the extremities, tingling in the fingers, etc. occur.

To avoid the development of unpleasant conditions, it is strictly forbidden to drink alcohol during treatment with Isoprinosine.

Possible side effects

While taking the medication, certain side effects may develop. During treatment with Isoprinosine, a person may experience:

• bouts of nausea, in some cases ending in vomiting;
• pain in the epigastric region;
• stool disorder - diarrhea or diarrhoea;
• it is possible to increase the activity of AST and ALT, as well as alkaline phosphatase - it is determined during a biochemical blood test;
• an increase in the content of uric acid in the blood is not excluded;
• itchy rashes on the surface of the skin;
• headache;
• bouts of dizziness;
• unexplained weakness;
• sleep problems (both insomnia and increased drowsiness can form);
• increased urine output - more than two liters in 24 hours;
• soreness in the joints;
• exacerbation of gout.

In general, the drug is well absorbed by the patient's body and does not cause the formation of side effects even with prolonged use.

Contraindications to the appointment

The medicine is not prescribed in the following cases:

• with diagnosed gout (deposits of urate salts in the joints and tissues);
• the formation of stones in the kidneys and bladder;
• in the presence of cardiac arrhythmias;
• with a tendency to allergic reactions;
• during childbearing and subsequent breastfeeding.

If a person has problems with the excretion of uric acid during therapy with Isoprinosine, it is necessary to check the level of urate in the blood. If the course of treatment is more than two weeks, then it is necessary to control:

• composition of peripheral blood;
• the amount of uric acid in the blood plasma;
• creatinine level.

Antiviral treatment with Isoprinosine is recommended for HPV patients (in the absence of contraindications) quite often, especially when diagnosing genital warts. Genital warts are prone to recurrence, and taking the drug increases the effectiveness of treatment from 66% to 88%.

The human papillomavirus (HPV) is the cause of not only papillomas, or warts, but also dysplasia, cancer of the cervix, vagina, anus in women, and cancer of the penis and anus in men. At this stage, there are no effective therapies that can completely destroy HPV, so the treatment combines local and systemic methods aimed at removing areas of altered epithelium and turning HPV into an inactive state. Isoprinosine from the human papillomavirus successfully copes with the second task, providing a complex antiviral and immunomodulatory effect on the body.

Therapeutic tactics for HPV infection

The direction and volume of therapy largely depend on the activity of HPV in the body. Human papillomavirus in epithelial cells can exist in two forms.

Only the destruction of papillomatous formations does not guarantee a lasting effect. The absence of recurrence of the disease can be achieved by the use of medications that enhance the local and general immune response, converting the virus into an inactive form. These agents include Isoprinosine, which is registered in more than 70 countries and has received numerous positive reviews from practitioners. However, it should be noted that there was no evidence of its effectiveness in studies.

Release form and composition

Isoprinosine is available in the form of white or almost white tablets with a slight characteristic amine odor. The therapeutic effect is exerted by the active substance of the drug - inosine pranobex, the content of which in one tablet is 500 mg. The auxiliary components included in the composition include: mannitol (E 421), povidone, magnesium stearate and wheat starch.

Characteristics of the drug

The main properties of Isoprinosine are presented in the table.

Dosing regimens for Isoprinosine in HPV

Isoprinosine from papillomas is taken after a meal, washed down with a small amount of water, in the following dosage.

The duration of treatment for genital warts and cervical dysplasia is determined by the nature of the course of the disease, the severity of clinical manifestations, and the immune status of the patient.

Possible side effects of the drug

Isoprinosine, according to numerous patient reviews and observations of specialists, is well tolerated. One of the side effects of taking the drug, due to the peculiarities of its metabolism in the body, is a transient increase in the level of uric acid in the urine and blood serum.

The instruction to Isoprinosine contains a list of side effects that may occur in patients while taking the medication.

Contraindications

Treatment of HPV infection with the drug is contraindicated if the patient has:

• individual intolerance to the constituent components;
• kidney pathology (urolithiasis, chronic renal failure);
• heart rhythm disturbances;
• body weight less than 15–20 kg (children from 1 year old can theoretically be prescribed the drug, but given the weight restrictions, in practice, the drug can be taken after 3 years).

When it comes to allergic manifestations, it is necessary to take into account not only the reaction to the active substance, but also to additional auxiliary components that make up the product.

Taking into account the possibility of long-term administration of Isoprinosine, the functioning of the kidneys and liver should be monitored during its administration. Laboratory studies help to cancel the drug in time if there are indicators that go beyond the limits of permissible deviations.

To date, the drug is presented only in tablet format. Its therapeutic effect is based on slowing down the reaction of DNA and RNA production in the nucleus of a viral cell. In addition, Isoprinosine is a good immunostimulant.

Against the background of taking the drug, the production of endogenous cytoleukins and human interferon is activated. It is this action that determines the properties of the drug:

• antiviral;
• anti-inflammatory;
• immunostimulating.

The tool is widely used in the treatment of acute forms of HPV. It affects not only the changed cells, but also the virus itself.

Isoprinosine enhances systemic immunity, and also activates local immune defenses. This means that its intake has a direct effect on the epithelium affected by the virus.

The dual effect of Isoprinosine - immunostimulating and antiviral - allows the use of the drug in the fight against many HPV genotypes, including highly carcinogenic ones.

The drug is rapidly absorbed by the mucosa of the intestinal tract. The maximum drug in the blood is determined one and a half hours after administration. Isoprinosine is excreted through the kidneys along with urine. It does not have a cumulative effect: it is completely eliminated after 2 days.

The human papillomavirus must be treated with medications that act on the structures of the pathogen and prevent it from spreading throughout the body. Isoprinosine copes well with this task.

It can be purchased at any pharmacy after giving the pharmacist a prescription from a doctor. And this means that the medicine should be prescribed by a specialist, since with self-treatment, the patient runs the risk of worsening the condition.

1 tablet contains 500 mg of the main component of inosine pranobex. It is used to suppress the activity of papillomavirus. Thanks to him, the drug copes with such diseases and restores the work of lymphocytes, even despite reduced immunity.

Tablets: oblong, biconvex, white or almost white in color with a slight amine odor, scored on one side.

Isoprinosine during pregnancy

The safety of the use of Isoprinosine during pregnancy and lactation has not been established, so the use of the drug is not recommended.

The use of Isoprinosine during pregnancy has not been clinically studied. This means that there is simply no information about the effect of inosine pranobex on the fetus and the course of pregnancy.

This medicinal product is used only if the benefit to the mother far outweighs the risk to the baby. However, for the treatment of viral infections in pregnant women, there are a number of safer agents than Isoprinosine, for example, interferon preparations.

I would like to reassure future mothers who took Isoprinosine, not yet knowing about the pregnancy that had begun. The likelihood of any negative effect of the drug in the early stages is very small. Therefore, it is better not to torment yourself with the mythical consequences of treatment, but to learn how to enjoy pregnancy.

Treatment of HPV with Isoprinosine

Chickenpox gets its name from the microorganism that causes it, the varicella zoster virus. A childhood illness known to all is usually completely harmless.

Chickenpox goes away on its own within a few weeks, and in most cases does not require special treatment. With the exception of the artistic procedure with the use of brilliant green, which, by the way, is used only in the territory of the former USSR.

However, children with weakened immune systems can tolerate chickenpox quite hard. And chicken pox at a conscious age is already a serious disease that can become a real test even for the most healthy person. In such cases, chickenpox requires timely adequate treatment, which will help to quickly cope with the disease.

Isoprinosine, which is active against the Varicella Zoster virus, is widely used in chickenpox. It has been clinically proven that due to treatment with Isoprinosine, the duration of the disease is significantly reduced.

In addition, chickenpox is much milder, the number of rashes decreases. Already existing elements of the rash heal faster.

At the same time, the itching, which causes a lot of trouble to the patient, also weakens.

Papillomavirus infection is a very common viral disease. It's hard to imagine, but about 80% of the population is infected with one form or another of HPV (human papillomavirus).

The microorganism, which has more than 130 species, can persist asymptomatically throughout life. And it can cause a variety of diseases, ranging from innocent warts to cancer.

It is impossible to cure papillomavirus, and symptomatic treatment is aimed at combating the manifestations of the disease. Isoprinosine is one of the antiviral drugs that is effective against HPV.

However, it should be borne in mind that the human papillomavirus treatment regimen includes several agents, and Isoprinosine is only one of them. Usually inosine pranobex is prescribed in the complex therapy of benign manifestations of papillomavirus.

Isoprinosine is used as part of the complex treatment of genital warts, which are formed as a result of infection with low-oncogenic and medium-oncogenic types of papillomavirus. Sometimes Isoprinosine is included in the treatment of cervical erosion and dysplasia. Indeed, in the vast majority of cases, these diseases are also caused by the human papillomavirus.

Patient reviews speak generally about the positive results of Isoprinosine therapy for HPV infection caused by low-oncogenic types of the virus.

Every good doctor has his own therapy regimen, which has already proven its effectiveness. Therefore, a single standard course of treatment with Isoprinosine probably simply does not exist.

The instructions for Isoprinosine 500 mg indicate that the duration of therapy for uncomplicated forms of infection is from 5 days to two weeks. In addition, experts in some cases recommend continuing Isoprinosine for another two weeks after the disappearance of symptoms of the disease. This is necessary in order to avoid recurrence of the disease.

Perhaps a long-term appointment of inosine pranobex for a month or even more. And again, we emphasize that in such a delicate matter as the treatment of viral infections, it is worth relying not on the instructions for Isoprinosine or the reviews of a friend, but on the experience and knowledge of the attending physician.

abstract review

Papillomavirus infection (PVI) is considered the main etiological factor not only for papillomas, but also for cervical intraepithelial neoplasia (CIN) and cervical cancer (CC). This infection is often combined with other infections - bacterial vaginosis, herpes virus, chlamydia, candidiasis, gonorrhea 1 , which makes it difficult to diagnose.

There are no methods of therapy to achieve eradication of the human papillomavirus (HPV), and therefore the treatment consists of local (destructive; physiosurgical) and systemic (immunostimulating and antiviral) components 2 .

At the same time, the cost of destructive treatment is high, and it does not guarantee the complete disappearance of the virus from locally remote areas of the altered epithelium, in addition, PVI resolves spontaneously in many cases, so many foreign experts recommend monitoring this infection with regular cytological control.

The early stages of CIN are often accompanied by infection with the usual opportunistic flora (staphylococcal, streptococcal, etc.), chronic cervicitis and vaginitis, leucorrhoea (Prilepskaya V.N.).

It is possible to treat such patients without resorting to destructive methods, but both antiviral and immunomodulatory treatment is required to achieve a sustainable effect. One of the drugs that provides this effect is Isoprinosine.

Isoprinosine has been used in world medical practice since the beginning of 1970. It is registered in 73 countries of the world. Chemically, Isoprinosine is a purine derivative, therefore it is metabolized in a cycle typical of purine nucleotides, with the formation of uric acid, and excreted by the kidneys within 48 hours.

Due to this, Isoprinosine is well absorbed in the gastrointestinal tract; however, it is not recommended for use in renal failure, gout, urolithiasis.

The pharmacological action of Isoprinosine is associated with the suppression of the synthesis of DNA and mRNA of viruses in the ribosome of cells, the activation of T-lymphocytes (moreover, it even blocks the inhibitory effect of glucocorticoids on them), with the stimulation of phagocytic cells (due to the activation of biochemical processes in them). In addition to cellular immunity, the drug activates the synthesis of antiviral proteins - interferons.

These properties allow it to act particularly effectively in manifest forms of HPV infection, usually caused by the combined action of social factors, infections (sexually transmitted diseases), and changes in the immune status.

In a randomized, double-blind, placebo-controlled study, Isoprinosine was effective in subclinical HPV lesions of the vulva 3. The study involved 55 women divided into 2 groups who received either Isoprinosine (1000 mg 3 times a day) or placebo for 6 weeks.

In the treatment group, a statistically significant decrease in vulvar itching was noted, and it was also combined with a morphological improvement in the condition of the vulvar epithelium (p = 0.005). These positive changes persisted 4 months after the start of treatment.

Isoprinosine monotherapy is also effective in CIN. The effectiveness of treatment with Isoprinosine can be assessed using cytological control, examination with the naked eye and colposcopy.

In a comparative study of various outpatient methods for diagnosing HPV cervical lesions involving 640 women 4, it was shown that colposcopic examination is optimal for screening purposes.

In a clinical study with Isoprinosine monotherapy at 50 mg / kg 3-4 times / day in 44 women suffering from CIN I (28 women; therapy for 10 days) and CIN II (16 women; for 21 days), it was found that pronounced the clinical effect was observed in 88.6% of patients - the lesion of the exocervix epithelium completely disappeared, which was confirmed colposcopically and histologically 5 .

Relapse developed after 6 months in only 2.6% of cases of effective treatment. It should be noted that simultaneously with the virological effect, an immunological effect was also achieved: the number of T-lymphocytes, the CD4/CD8 immunoregulatory index increased.

In a similar study involving 29 women with CIN I on the background of chronic cervicitis, the combination of etiotropic therapy with Isoprinosine 1000 mg 3 times a day for 10 days provided a clinical effect (disappearance of leucorrhea) in 72% of cases and HPV eradication at a 3-month follow-up in 66% of cases (Prilepskaya V.

It is known that under the influence of concomitant infections (urogenital chlamydia, mycoplasmosis, cytomegalovirus and herpetic infections, dysbiotic conditions), the duration of treatment for HPV infection is extended by an average of 3 times, relapses of the infection often develop, and it becomes more chronic 6 .

In this regard, such combined lesions are usually treated locally (medical and surgical; the effectiveness of local treatment reaches only 85-90%). The most promising is the combined method - the removal of warts on the background of systemic antiviral treatment 7 .

Its effectiveness reaches 100%, which is associated with the effect of the drug on HPV not only in the hard-to-reach areas for surgical or laser exposure, but also in the nerve ganglia 8 .

In the acute phase, Isoprinosine is prescribed at 50 mg / kg of the patient's body weight (6-8 tablets / day, divided into 3-4 doses) for 5 days. When the relapse subsides (starting from the 6th day), a maintenance dose is prescribed: 1 tablet 2 r / day for up to 6 months 9 .

A scheme with a threefold repetition of the course of therapy with an interval of 1 month was also proposed. In the treatment of small, multiple genital warts with a low degree of malignancy, the drug is proposed to prescribe 2 tablets 3 times a day for 14-28 days (Bogatyrev I.

One option for combination therapy is to first suppress the HPV infection with medication, then carry out a destructive treatment. In a prospective study using Isoprinosine in 54 patients with CIN grade I-III, as well as in situ cervical cancer, HPV type 16 and/or type 18 infection (associated with a risk of developing cervical cancer) was detected in 83% of patients, and they underwent courses of therapy Isoprinosine 1000 mg 3 times a day for 10 days with a follow-up examination after another 10 days 10 .

In 87% of cases, one course of treatment was sufficient, in 20% of cases 2 courses were required, and only in 2% of cases - 3 courses. The authors concluded that postoperative management of patients with CIN should be treated with antiviral therapy, since the activity of the virus is of key importance for the recurrence of the disease.

In another study, Isoprinosine therapy (1000 mg 3 times a day for 5 days) 7-10 days before cryodestruction of CIN I foci increased the effectiveness of treatment up to 88% (compared to 66% with only local cryodestruction) (Prilepskaya V .

N.). At the same time, HPV activity was not detected in 66 and 47% of cases, respectively, and infection relapses developed in 9 and 28% of cases, respectively.

Clinically, when HPV was cleared, epithelization of the cervix also improved. In another study, the frequency of recurrence of HPV lesions of the cervix after combination therapy in 62 women with CIN II-III was 1.6% (Zabelev A.

In general, the effectiveness of Isoprinosine therapy is higher with a lower degree of CIN: in one study with CIN I it was 93%, with CIN II - 81% (Potapov V. A.), and in another study with CIN I-II - 15 out of 20 ( 75%) of patients after the first course of therapy (Kedrova A.

G.). It is also important to note that the degree of CIN is usually proportional to the duration of the disease and the age of the patients (eg, in an outpatient study of 640 patients, the mean age in CIN II was 35 and in CIN III 46 years).

This is probably due to the longer persistence of HPV, which causes more pronounced lesions of the epithelium of the cervical mucosa (Potapov V.A.).

It should be noted that Isoprinosine therapy is well tolerated. So, in a study of 54 patients with CIN and cervical cancer, a total of 58 courses of treatment with Isoprinosine were carried out and an allergic reaction (rash) developed only in one case - during the second course of therapy.

The reaction was stopped within 3 days with the use of antihistamines (Kedrova A.G.).

4 cases of mild malaise and nausea were also considered possibly related to the drug. In a study of 29 women with CIN I, no side effects were found when taking Isoprinosine (Prilepskaya V.

N.). In a study of 55 women who received the drug for HPV infection of the vulva, in 2 cases skin rashes were noted, mild and stopped without treatment (Tau S.

K.). This may be partly due to the fact that the drug is a derivative of a natural substance - purine.

Due to the dual - antiviral and immunomodulatory - action, Isoprinosine inhibits the replication of various types of HPV, including

and highly oncogenic, which ensures its effectiveness in any clinical and subclinical form of PVI (genital warts and CIN). With CIN, the drug is effective and safe both in the early stages, incl.

hours as monotherapy, and later - as part of a combined drug and destructive therapy.

Published based on the materials of the book: Gynecology: A Guide for Doctors / Serov V.N., Kira E.F., Apolikhina I.A., Antonova I.B. and etc.; Ed. V.N. Serov, E.F. Kira. - M.: Litterra, 2008. pp. 500-502

Papillomavirus infection is equally common among the male and female population, and children, including infants, are also susceptible to the disease. HPV 16 and 18 strains require mandatory therapy, as it belongs to the carcinogenic group and can lead to the development of a malignant process.

You can pick up the pathogen anywhere, so do not neglect the prevention of HPV type 16. To do this, you need to exclude casual sexual relationships, stress, do not use other people's things, constantly try to strengthen the immune system.

Do I need to treat HPV 16, 18?

This is the question that patients ask after the diagnosis. The pathogen is able to stay in the body for a long time and not show signs of its existence, its activation is provoked by a decrease in the body's support under the influence of negative factors.

Description of the dosage form

A distinctive feature of Isoprinosine is its high safety, which is clinically confirmed.

Already two hours after taking the Isoprinosine tablet in the blood, the maximum concentration of the active substance is reached. This is possible due to excellent bioavailability: 90% of inosine pranobex is absorbed into the blood. How not to remember with a kind word the animal origin of the drug, thanks to which it has an affinity for our body and is perfectly absorbed?

Isoprinosine tablet is completely eliminated from our body 24-48 hours after ingestion. At the same time, cumulation, that is, the accumulation of the active substance with prolonged use, is completely excluded.

Comparative studies of the safety of antiviral agents in laboratory animals have been conducted in clinical settings. In addition to Isoprinosine, the well-known drugs Arbidol and Ingavirin participated in the experiments. Studies have shown that the level of toxicity of Isoprinosine is several times lower than that of other drugs.

During the experiment, laboratory animals received a dose of inosine pranobex, ten times higher than the standard therapeutic dosage. Despite all the hardships, the experimental mice came out of the studies safe and sound: there were no changes in behavior, reflexes and other vital signs.

Thus, the safety of Isoprinosine is definitely higher than that of many other drugs from the antiviral group.

Before you continue reading: If you are looking for an effective method of getting rid of a runny nose, pharyngitis, tonsillitis, bronchitis or colds, then be sure to check out this section of the site after reading this article. This information has helped so many people, we hope it will help you too! So, now back to the article.

HPV type 18 (papillomavirus), warts, the fight against SARS and other "sores". AND A LOT OF SIDES APPEARED! Review updated. MARCH 2018

Hello again!_______________________

This time, continuing the theme of the fight against HPV 18, I want to talk about the immunostimulant Isoprinosine.

Tablets can be purchased in different packaging.

There are packs of 20 tablets, 30 and 50 tablets.

The doctor prescribed me Isoprinosine three times a day for 10 days. In total, I needed 30 tablets, but I "stupid" and bought 60 tablets ..

It seems that I hope that maybe they will come in handy for me in the next course of fighting the virus, but considering how I endured Isoprinizin, it becomes scary. But more on that below.

Here you have Isoprinosine and Panavir and LavoMax.

I bought 3 packs of Isoprinosine, 20 tablets each, the price of one pack is 604 rubles.

The tablets are rather large, white, slightly rough, i.e. not covered with glaze, which is VERY BAD, because the tablets are BITTER. Have you ever drunk chloramphenicol? It is precisely with him that I associate this bitterness.

Indications:

• therapy of the influenza virus and other acute respiratory viral infections;
• infectious diseases that were caused by the herpes virus types 1, 2, 3, 4 and 5 (recently there has been evidence of effectiveness in the treatment of herpes types 6, as well as types 7 and 8), labial herpes, genital herpes and herpetic keratitis;
• chickenpox, shingles;
• infectious mononucleosis due to herpes virus type 4 (Epstein-Barr virus);
• measles (with severe disease);
• cytomegalovirus infection caused by herpesvirus type 5;
• molluscum contagiosum;
• human papillomavirus infection (HPV), including papillomas of the vocal cords and larynx, fibrous type;
• the drug is also effective in HPV of the genitals in women and men and in therapy for getting rid of warts.

I want to focus my attention on such an important criterion in taking medications as side effects. This has never happened to me before. Either the pills themselves are like that, or the age approaching thirty makes itself felt.

There are many side effects, I will quote only those that manifested themselves in me:

• often - pain in the epigastric region, feeling of nausea, vomiting.
• sometimes - constipation or diarrhea.

• often - headaches, weakness, feeling of dizziness.
• sometimes - sleep disturbances (drowsiness or insomnia).

It is better to take Isoprinosine tablets ONLY AFTER a heavy meal. The third reception, in the evening, I had after a light dinner (fruits, kefir) and for three days I did not understand why I was so sick. As a result, after reading the side effects in the instructions for the drug, I realized that it was because of him that I felt sick. I started to have a tight dinner and take a pill after eating, the situation improved, but weight gain started ..(

The second manifestation of the gastrointestinal tract came to light in me in the form of constipation. So I haven't suffered in a long time. The abdomen is full, heaviness, constant discomfort and gases.

My head hurt terribly irritability against this background.

Insomnia also appeared, and as a result, daytime weakness. I can’t fall asleep until 2 am, getting up at 6 am and 4 hours of sleep became a torment at work.

It takes more than one month to treat HPV, as my doctor said, we'll see what the tests show in half a year. But, it will not be possible to calculate the merit of which of the three drugs used anyway.

In the indications of this drug, in reviews about it, an effective fight against warts is indicated, which causes the same HPV, only a different strain, not 18. But, alas, the drug did not show itself in any way in this matter. I have a flat plantar wart on my big toe. She still lives on me.(

I put a deuce, taking into account the side effects, the nasty taste and the inhabitant of my leg, and I don’t want to recommend it for the same reasons.

I also want to note that the drug has many analogues, for example, groprinosin, but it was not in the pharmacies of the city, although the side effects are the same.

The polyp still did not resolve. I had to have it removed surgically.

Dosage and administration

Since an overdose of the drug can lead to the development of negative reactions, it is important to strictly observe the permissible dosage when treating HPV with Isoprinosine. The treatment regimen is prescribed exclusively by the observing doctor, and the drug itself is sold in pharmacies by prescription.

According to the instructions, if there are growths on the body or mucosa, as well as in the event of indirect symptoms of the presence of papillomavirus in the body, the use of the drug is permissible for patients from the age of three. The very scheme of treatment of the disease is absolutely independent of what type of HPV is present in the body.

1. 2 tablets 3-4 times a day for adult patients. The duration of the course of treatment is 2-4 weeks. After this time, a break is made in taking the drug for 1 month. If necessary, the therapeutic course is repeated;
2. For children over 3 years old and weighing more than 15 kg, the dosage of the drug is calculated according to the formula 0.5 tablets per day for every 5 kg of body weight. The maximum daily dosage for a child is 2500 mg of the substance, which corresponds to 5 tablets. The dose corresponding to the weight of the child is taken 4 times. The course of treatment depends on the size and number of formations and can last 2-4 weeks.

This scheme of taking the drug is relevant only in the treatment of HPV. To eliminate other infectious or viral diseases, the dosage and frequency of administration are changed.

Isoprinosine is recommended for various types of warts, including genital warts and papillomatosis. The dosage of the drug is individual in each case and depends on the age group of the patient:

• for adolescents from 12 years old and the adult category of patients, it is recommended to take Isoprinosine three times a day. The dose of the drug depends on the weight of the patient. We drink the tablet as a whole, without crushing and drinking plenty of clean water;
• for children three to eleven years old, the selected dose is divided into three to four doses.

Dose calculation

The dosage of the drug for an adult is calculated based on the weight of the patient: 50 mg of Isoprinosine per 1 kg of body weight or one tablet for every ten kilograms of weight.

As a rule, the individual dosage is not calculated. The average daily dose for a person with a normal weight of 60-80 kg is six to eight pills. But in childhood (3 - 11 years), the dose is calculated necessarily. For every ten kilograms of weight, one tablet is taken. The resulting norm is necessarily divided into several doses (most often a four-time intake is recommended).

In severe HPV, the dosage calculation is performed somewhat differently. In this case, 100 mg of the drug or two pills for every ten kilograms of body weight should be taken per 1 kg of adult weight. For children, the allowable daily dose of the drug should not exceed 50 mg per 1 kg of body weight, regardless of the severity of papillomavirus infection.

Elderly patients - over 65 years of age - should take Isoprinosine at the standard dosage intended for adults. The duration of treatment depends on the type of disease, i.e. how long to drink Isoprinosine is decided by the attending physician.

Therapy with Isoprinosine

Identified papillomas of any localization, as well as genital warts (genital warts) require a fairly long time to take the drug - 14-28 days. In this case, warts found on the genitals are subject to mandatory removal.

The dosage of the drug depends on the age of the patient. Children over 12 years of age and adults are most often prescribed 2 tablets three times a day. Children under 11 years of age should receive a dose of the drug, calculated on the basis of the child's weight: for 10 kg of body weight, we take 1 tablet of Isoprinosine.

The received dose should be divided into three to four doses. The duration of treatment is 14 - 28 days. With the human papillomavirus, which is manifested by the formation of only skin warts, one course of taking the drug is enough.

But when genital warts are detected, the patient is recommended to conduct two courses. The first - after the removal of neoplasms, the second - a month after the completion of the first. When diagnosing cervical dysplasia, the following therapeutic regimen is used:

• within 10 days, a woman needs to take 2 tablets of the drug three times a day;
• then you need to take a two-week break and repeat the treatment.

In total, two or three courses are required. Isoprinosine gives positive results in about 90% of all cases.

According to statistics, it is in this percentage of patients who took the drug at the recommended dosage that histological studies of the epithelium of the cervical canal show a complete absence of viral load.

Recurrence of the disease during the first six months was recorded only in 3% of patients.

The drug is prescribed to people with papillomas and warts. For each patient, the dosage of the drug is selected individually. Attention is drawn to the age of the patient and his state of health. The dose of the drug may be as follows:

1. Adults and children under 12 years of age should take Isoprinosine three times a day. The dosage will depend on the weight of the patient. You should take the tablet completely, trying not to crush it and drink plenty of water;
2. Children from 3 years old can take the medicine in the amount of 1/3 tablet. The whole pill is divided into 3 doses. The halves are also washed down with a sufficient amount of drinking water.

As mentioned above, the calculation of the dosage of the drug is selected based on the weight of the sick person. For each kg there are 50 mg of the drug. It turns out that 1 tablet is intended for 10 kg of weight.

Sometimes doctors do not calculate individual dosages, but take average values. According to them, people weighing 60 to 80 kg should drink 6-8 tablets. Average values ​​should not be taken when selecting a dose for young children.

If papillomavirus is severe, then the optimal dosage will be determined according to a slightly different pattern. In this case, 100 mg of the drug is taken for each kg of weight. It turns out that 2 tablets are required for 10 kg. If a child needs treatment, then only 50 mg of the drug is taken per 1 kg of weight. In the situation with children, the severity of the pathology is not taken into account.

Elderly patients who are over 65 years of age should be treated with Isoprinosine, adhering to the standard adult dosage.

Regardless of where exactly the viral rashes are located, the patient will need to undergo treatment for a long enough time to suppress the activity of the disease and stop its spread.

If a person has genital warts, he will need to take 2 courses of Isoprinosine at once. The first is carried out after the removal of problematic rashes. The second course is started about a month after the completion of the last therapy.

If taken correctly, the drug "Isoprinosine" gives a positive result for about 90% of patients. Relapse of the disease was recorded only in 3% of patients during the first 6 months after the end of the therapeutic course.

The results obtained convince patients to fight warts, eliminate warts, using these particular pills. Physicians adhere to the same opinion. "Isoprinosine" is guaranteed to help get rid of warts and papillomas, which cause discomfort and make a person feel insecure.

Inside, after eating, drinking a small amount of water.

The recommended dose for adults and children from 3 years of age (body weight from 15-20 kg) is 50 mg / kg / day, divided into 3-4 doses. Adults - 6-8 tablets / day, children - 1/2 table / 5 kg / day. In severe forms of infectious diseases, the dose can be increased individually to 100 mg / kg / day, divided into 4-6 doses. The maximum daily dose for adults is 3-4 g / day, for children - 50 mg / kg / day.

Duration of treatment

In acute diseases: the duration of treatment in adults and children is usually from 5 to 14 days. Treatment should be continued until the disappearance of clinical symptoms and for another 2 days in the absence of symptoms. If necessary, the duration of treatment can be increased individually under the supervision of a physician.

In chronic recurrent diseases in adults and children, treatment should be continued in several courses of 5-10 days with a break in admission of 8 days.

For maintenance therapy, the dose can be reduced to 500-1000 mg per day (Table 1-2) for 30 days.

In case of herpetic infection, adults and children are prescribed for 5-10 days until the symptoms of the disease disappear, in the asymptomatic period - 1 table. 2 times a day for 30 days to reduce the number of relapses.

With papillomavirus infection for adults, the drug is prescribed in 2 tablets. 3 times a day, children - 1/2 tab. / 5 kg body weight / day in 3-4 doses for 14-28 days as monotherapy.

For recurrent genital warts, adults are prescribed 2 tablets. 3 times, for children - 1/2 table / 5 kg / day in 3-4 doses per day, either as monotherapy or in combination with surgical treatment for 14-28 days, then with a three-fold repetition of the indicated course at intervals of 1 month

With cervical dysplasia associated with the human papillomavirus, 2 tablets are prescribed. 3 times a day for 10 days, then 2-3 similar courses are carried out with an interval of 10-14 days.

The classic indication for the use of Isoprinosine is a viral infection against the background of a weakened immune system. In such situations, inosine pranobex is practically the drug of choice.

According to statistics, Isoprinosine is used in many countries of the world for various indications, including:

• influenza and SARS - acute respiratory viral infections;
• infections associated with herpes simplex virus;
• infections caused by the Varicella Zoster virus;
• Infectious mononucleosis;
• cytomegalovirus infection;
• measles;
• papillomavirus infection;
• molluscum contagiosum.

Contraindications

In most cases, the reaction of the patient's body to inosine pranobex is positive and the treatment does not cause side effects. However, there are some contraindications to the use of the drug. Isoprinosine should not be taken in such cases:

• gout;
• urolithiasis, as well as a condition of elevated levels of uric acid in the body;
• kidney failure;
• arrhythmia.

Also, the use of the drug is unacceptable in case of impaired metabolism of inosine pranobex, and hypersensitivity to any auxiliary components of the drug.

Since the regular use of the drug has an increased burden on the liver and kidneys, the use of the drug simultaneously with alcohol is unacceptable.

Side effects

The medicine is not prescribed in the following cases:

• with diagnosed gout (deposits of urate salts in the joints and tissues);
• the formation of stones in the kidneys and bladder;
• in the presence of cardiac arrhythmias;
• with a tendency to allergic reactions;
• during childbearing and subsequent breastfeeding.

If a person has problems with the excretion of uric acid during therapy with Isoprinosine, it is necessary to check the level of urate in the blood. If the course of treatment is more than two weeks, then it is necessary to control:

• composition of peripheral blood;
• the amount of uric acid in the blood plasma;
• creatinine level.

Antiviral treatment with Isoprinosine is recommended for HPV patients (in the absence of contraindications) quite often, especially when diagnosing genital warts. Genital warts are prone to recurrence, and taking the drug increases the effectiveness of treatment from 66% to 88%.

"Isoprinosine" copes with various infections that are viral in nature. It is prescribed to patients suffering from the following diseases:

• respiratory infections;
• Mononucleosis;
• Herpes;
• Measles;
• Molluscum contagiosum;
• Papillomavirus;
• Genital warts;
• Warts.

The drug fights well against those infections that suppress the activity of the immune system, making the body unprotected before their attack.

"Isoprinosine" helps to cope with the infection. But not all people who are affected by the human papillomavirus can afford to undergo treatment based on this drug. This is because, like any other medicine with a huge amount of chemicals, it has a number of contraindications. It is forbidden to take medicine for patients with papillomavirus, which are characterized by the following conditions:

• Gout;
• Tendency to allergies;
• Violation of the heart rhythm;
• Pregnancy;
• Lactation;
• Stones in the kidneys or bladder.

The drug should be taken with caution in patients who have difficulty in excreting uric acid. They should have their urate levels checked regularly. Such control will avoid negative reactions while taking Isoprinosine.

treatment of influenza and other acute respiratory viral infections;

infections caused by the Herpes simplex virus types 1, 2, 3 and 4: genital and labial herpes, herpetic keratitis, herpes zoster, chicken pox, infectious mononucleosis caused by the Epstein-Barr virus;

cytomegalovirus infection;

severe measles;

papillomavirus infection: papillomas of the larynx / vocal cords (fibrous type), papillomavirus infection of the genitals in men and women, warts;

molluscum contagiosum.

hypersensitivity to the components of the drug;

urolithiasis disease;

chronic renal failure;

children's age up to 3 years (body weight up to 15–20 kg).

Among the contraindications to taking Isoprinosine, the leading place is occupied by kidney pathologies: chronic renal failure, urolithiasis. In addition, due to the increase in the level of uric acid, the drug is also contraindicated in gout. Note that with long-term treatment with Isoprinosine, experts recommend examining the main renal parameters every four weeks.

The instructions for the use of Isoprinosine also indicate that the drug is not recommended for use in children under three years of age who weigh less than 15 kilograms. This contraindication is based on the fact that no safety studies have been conducted in this category of patients.

Nevertheless, inosine pranobex for the treatment of certain diseases (for example, molluscum contagiosum) is used in pediatrics from one year of age.

Among the contraindications to taking Isoprinosine, one cannot ignore individual sensitivity to the active substance. Although the likelihood of such a reaction is very small, it cannot be ruled out. This is especially true for sensitive patients prone to allergic reactions.

Analogues and prices

Prices for the immunostimulating agent Isoprinosine directly depend on the number of tablets in the package. Manufacturers produce the medicine in packages of 10, 20, 30 and 50 pcs. In most network pharmacies, the cost of a drug ranges from 264-349 rubles. (124 - 164 UAH) for a pack of 10 tablets.

Since the drug is quite expensive, many people are looking for cheaper analogues of the drug. But at the same time, only Groprinosin and Novirin are drugs that have in their composition the same active substance (inosine pranobex). Their cost differs significantly from the prices for Isoprinosine and ranges from 101-124 rubles. (47-58 UAH) for a pack of 10 tablets.

In the treatment of HPV, other analogues of Isoprinosine, which have other active substances in their composition, can also be used as an immunomodulator. These drugs include:

• Likopid;
• Viferon;
• Panavir;
• Genferon.

Among all analogues with a different composition, the most effective drug is Allokin. The medicine is produced exclusively in the form of a powder for injection. It is prepared immediately before the injection, by diluting the contents of the ampoule with 1 ml of saline sodium chloride. The effectiveness of HPV treatment with this drug is 98%, while the duration of the course does not exceed 6 injections.

The only drawback of this drug is its price. In the cheapest pharmacy, a package of 3 ampoules of Allokin will cost at least 4166 rubles. (1958 UAH).

Prices for other analogues of Isoprinosine start at 426 rubles. (200 UAH).

The drug can be purchased at a price of 540 to 715 rubles per pack, which contains 20 tablets. The cost of "Isoprinosine" is affected by the pricing policy of the pharmacy, as well as the manufacturer.

Patients are interested in how to take Isoprinosine for HPV. Isoprinosine is one of the most effective antiviral drugs, moreover, it has immunomodulatory properties. This has been proven by clinical studies.

What is the principle of action of Isoprinosine?

This drug was first released in the United States and the first studies were carried out there, which proved that it is not only an effective antiviral agent, but also an immunomodulator. In the Russian Federation, this HPV treatment appeared only at the end of the 90s of the XX century, but almost immediately became the leader in sales and prescriptions in its group of drugs, since its safety and effectiveness in the fight against human papillomavirus have already been proven.

The maximum concentration of the substance in the body occurs 1 hour after ingestion, and the drug is excreted from the body within 24 hours, and the active substance does not accumulate in the body. It is not toxic.

To date, this tool is sold in more than 70 countries around the world, and the number of indications for use is increasing almost every day. Most often it is used as an immunotropic. The main active ingredient of the drug, inosine, is of natural origin and plays an important role in shaping the correct course of various biochemical processes in the human body.

The drug promotes the formation of T-lymphocytes in the body, which destroy the cells of the body damaged by the papilloma virus. This remedy also contributes to the production of the so-called interferon, which increases the body's resistance to all pathogenic bacteria and viruses. Inosine pranobex promotes the inhibition of viruses and blocks those enzymes that are responsible for copying viruses in the human body.

Isoprinosine - an antibiotic or not? Many patients are concerned about whether this HPV drug is an antibiotic. It can be answered unambiguously: it is not an antibiotic, but an immunomodulating agent, which is most often prescribed in combination with antibiotics or interferons.

The release form of the drug is an oral tablet, which contains 250 ml of the active substance. There are packs of 20, 30 and 50 tablets each. You can choose any option that is suitable for a strictly individual course of HPV treatment.

Indications for the use of the drug

The drug is used to treat and restore immunity in:

• SARS;
• herpes;
• papillomavirus infection and in many other cases.

With HPV, Isoprinosine is very effective. The papilloma virus can be extremely dangerous and can be expressed in the form of the appearance of ordinary and harmless warts or in the form of oncology. It is impossible to completely get rid of the virus, but the symptoms can be alleviated. You can also reduce the risk of developing papilloma into an oncological tumor.

Isoprinosine for papillomas is effective only in combination with other drugs. Isoprinosine is also prescribed in case of detection of genital warts, warts, as they are formed as a result of infection of the body with low-oncogenic and medium-oncogenic types of papillomavirus.

How to take pills for HPV?

HPV therapy with isoprinosine is one of the best solutions. Taking the drug is also necessary because it eliminates all possible risks of relapse.

What should be the dosage of the drug in the treatment of HPV? Doctors prescribe the dosage based on the patient's body weight. If several infections are found in the human body, the dosage may be increased. In any case, the scheme and course of treatment with Isoprinosine is always deeply individual.

How long does the treatment course last? Taking Isoprinosine for HPV is easy, and the course of treatment usually lasts 5-10 days. Interestingly, most experts have come to the conclusion that the duration of use is best extended to 2 weeks after the last symptoms disappear. This is necessary in order to minimize possible relapse options.

With different strains of HPV, the course necessarily varies. The maximum duration of admission (for example, with CIN - cervical intraepithelial neoplasia of the 2nd degree) is 21 days.

Warts and Isoprinosine: how to eliminate the symptoms? How to take the drug? There are no clear recommendations for admission. It can be taken before and after meals, as it practically does not affect the functioning of the digestive tract, since it immediately dissolves in the blood. It is not necessary to adhere to a special diet during treatment.

The tablet is taken as a whole (although crushing at risk is possible), washed down with plenty of water.

Side effects and contraindications

There are practically no side effects of the drug. That's only with an overdose, you can observe symptoms such as:

• gastrointestinal upset (diarrhea or constipation);
• joint pain;
• increased manifestations of gout;
• sleep disturbance (drowsiness or insomnia);
• headache.

If any of the above symptoms appear, you must immediately stop taking the drug. All doctors believe that in the process of treating any strain of HPV with this drug, it is necessary to constantly monitor such indicators as:

• composition of peripheral blood;
• creatine level;
• uric acid level.

This medicine is not prescribed if the patient suffers from:

• chronic kidney disease;
• urolithiasis;
• gout.

The drug is not prescribed for children under 3 years of age and older children if they weigh less than 15 kg.

The drug should not be taken if there is an individual intolerance to the main active substance. Allergic patients should take it with caution.

It is best not to take this medicine during pregnancy. For pregnant women, there are other, more gentle means of therapy. Isoprinosine from papillomas is as effective as possible (it copes with almost all strains of HPV) and, judging by the reviews of doctors and patients, it works great.

Relapses are very rare (clinical studies have shown that this occurs in only 3% of patients and only 6 months after the course of treatment). Its reception is justified even if surgical intervention is impossible, that is, when papillomas and condylomas cannot be removed even with a laser.