Clarithromycin is an imported analogue. How to take the antibiotic clarithromycin for adults and children - composition, indications, side effects, analogues and price

This table is built on the basis of data collected from the resources of pharmaceutical companies that produce these drugs. The average prices for drugs with a minimum dosage dispensed from Russian pharmacies in 2020 are indicated. Why analogues are cheaper than Clarithromycin A lot of time and money is spent on the manufacture of the chemical formula of a new drug, tests are carried out. The pharmaceutical company then buys the patent, then spends the money on advertising and puts it on the market. The manufacturer puts a high price on the drug in order to quickly recoup the investment. Other medicines similar in composition, less well-known but time-tested remain many times cheaper. Share your experience

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Clarithromycin is a semi-synthetic drug, an antibacterial agent used to treat various infectious and inflammatory diseases that are caused by microorganisms that are sensitive to the active substance.

On this page you will find all the information about Clarithromycin: full instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Clarithromycin. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Semi-synthetic macrolide antibiotic.

Terms of dispensing from pharmacies

Released by prescription.

Prices

How much does Clarithromycin cost? The average price in pharmacies is at the level of 100 rubles.

Release form and composition

The drug is used orally (from the Latin per os - through the mouth) and parenterally - intravenously drip (in "droppers"). Clarithromycin is available as:

• capsules (500 and 250 mg);
• tablets of long, or prolonged action (500 mg each);
• conventional tablets (250 and 500);
• lyophilized powder, from which an infant suspension is prepared;
• solution for intravenous drip.

The composition of the tablets includes the active ingredient clarithromycin, as well as additional components: MCC, potato starch, pregelatinized starch, low molecular weight PVP, colloidal silicon dioxide, magnesium stearate, sodium lauryl sulfate.

Pharmacological effect

The active substance of Clarithromycin acts bacteriostatically and bactericidal. The drug is active against:

• Gram-positive bacteria - Corynebacterium spp., Staphylococcus spp., Listeria monocytogenes, Streptococcus spp.;
• Gram-negative bacteria - Haemophilus influenzae, Helicobacter pylori, Haemophilus ducreyi, Bordetella pertussis, Neisseria gonorrhoeae, Moraxella catarrhalis, Neisseria meningitidis, Borrelia burgdorferi;
• Intracellular microorganisms - Ureaplasma urealyticum, Chlamydophila pneumoniae, Chlamydia trachomatis, Legionella pneumophila, Mycoplasma pneumoniae;
• Anaerobic bacteria - Peptococcus spp., Bacteroides melaninogenicus Eubacterium spp., Propionibacterium spp., Clostridium perfringens.

Clarithromycin is also active against Mycobacterium spp. (except Mycobacterium tuberculosis) and Toxoplasma gondii.

Quite a few analogues of Clarithromycin have been registered that have the same therapeutic effect.

Indications for use

It is used to treat infectious and inflammatory diseases caused by pathogens sensitive to clarithromycin, namely:

• odontogenic infections;
• skin and soft tissue infections;
• infections of the upper respiratory tract and ENT organs (tonsillopharyngitis, acute);
• mycobacterial infections (M.avium complex, M.kansasii, M.marinum, M.leprae) and their prevention in AIDS patients;
• infections of the lower respiratory tract (, exacerbation, community-acquired bacterial and atypical);
• eradication in patients with duodenal ulcer or gastric ulcer (only as part of combination therapy).

Contraindications

A history of QT interval prolongation, ventricular arrhythmia, or torsades de pointes; hypokalemia (risk of prolongation of the QT interval); severe liver failure occurring simultaneously with renal failure; cholestatic jaundice/hepatitis in history, developed during the use of clarithromycin; porphyria; I trimester of pregnancy; lactation period (breastfeeding); simultaneous administration of clarithromycin with astemizole, cisapride, pimozide, terfenadine; with ergot alkaloids, eg ergotamine, dihydroergotamine; with midazolam for oral administration; with HMG-CoA reductase inhibitors (statins), which are largely metabolized by the CYP3A4 isoenzyme (lovastatin, simvastatin), with colchicine; with ticagrelor or ranolazine; hypersensitivity to clarithromycin and other macrolides.

Clarithromycin should be used with caution in patients with moderate to severe renal impairment; liver failure of moderate and severe degree, with coronary artery disease, severe heart failure, hypomagnesemia, severe bradycardia (less than 50 bpm); simultaneously with benzodiazepines, such as alprazolam, triazolam, midazolam for intravenous administration; simultaneously with other ototoxic drugs, especially aminoglycosides; simultaneously with drugs that are metabolized by CYP3A isoenzymes (including carbamazepine, cilostazol, cyclosporine, disopyramide, methylprednisolone, omeprazole, indirect anticoagulants, quinidine, rifabutin, sildenafil, tacrolimus, vinblastine; simultaneously with CYP3A4 inducers (including rifampicin , phenytoin, carbamazepine, phenobarbital, St. John's wort); simultaneously with statins, the metabolism of which does not depend on the CYP3A isoenzyme (including fluvastatin); simultaneously with blockers of slow calcium channels, which are metabolized by CYP3A4 isoenzymes (including verapamil, amlodipine, diltiazem); simultaneously with class I A antiarrhythmic drugs (quinidine, procainamide) and class III (dofetilide, amiodarone, sotalol).

Use during pregnancy and lactation

The use of Clarithromycin in the first trimester of pregnancy is strictly contraindicated.

The use of the drug in the remaining stages of pregnancy is possible only in exceptional cases.

The use of Clarithromycin during lactation should occur only after a complete rejection of it.

Instructions for use

The instructions for use indicate that Clarithromycin is used orally, regardless of food intake and milk. It is recommended to adhere to the prescribed treatment regimen. The missed pill should be taken as soon as possible, but if it is almost time for the next pill, you should not take a double dose.

• If a different regimen is not prescribed by a doctor, then Clarithromycin is taken at 250 mg 2 r / day (for children over 12 years old and adults). According to indications, you can take 500 mg 2 r / day. The course of treatment is 5-14 days.

In renal failure, Clarithromycin is prescribed at a dose depending on creatinine clearance:

• Clarithromycin 500 mg: with clearance> 30 ml / min - 500 mg 2 r / day; with clearance<30 мл.мин – начальная доза насыщения – 500 мг, далее – по 250 мг 2 р/сутки.
• Clarithromycin 250 mg: with clearance> 30 ml / min - 250 mg 2 r / day; with clearance<30 мл/мин – по 250 мг 2 р/сутки.

For infections caused by mycobacteria, it is recommended to use Clarithromycin 500 mg 2 r / day. Perhaps the appointment in combination with other antibacterial agents. With widespread mycobacterial infection in patients with AIDS, drug therapy is continued until the microbiological and clinical state.

For the eradication of Helicobacter pylori infection, the following treatment regimens are used:

1. Three drugs - Clarithromycin 500 mg 2 r / day during treatment with proton pump inhibitors (pantoprazole, lansoprazole, omeprazole, etc.) and amoxicillin 1 g 2 r / day (10 days).
2. Two drugs - Clarithromycin 500 mg 3 r / day during treatment with proton pump inhibitors (pantoprazole, lansoprazole, omeprazole, etc.) - 14 days.

As a prophylaxis for the threat of mycobacterial infection, Clarithromycin is prescribed 500 mg 2 r / day.

In the treatment of infections of the dentition and jaw system - 250 mg 2 r / day (5 days).

Side effects

During therapy, the development of disorders from some body systems is possible:

With proper administration of the drug, cases of overdose are quite rare. In case of accidental ingestion of a large number of tablets or a significant excess of the recommended daily dose, the patient develops signs of an overdose. They are expressed in an increase in the above side effects and the development of severe liver disorders.

In this case, the patient is taken to the doctor, where his stomach is washed, sorbents are administered inside and symptomatic treatment is carried out if necessary. Hemodialysis will not be effective.

special instructions

1. Carefully, the remedy is prescribed when taking drugs, the metabolism of which takes place in the liver.
2. There is cross-resistance between antibacterial drugs that belong to the group of macrolides.
3. It should be borne in mind that the manifestation of severe diarrhea may be associated with pseudomembranous colitis.
4. If the patient is diagnosed with chronic diseases, he must definitely control the enzymes of the blood serum.
5. During antibiotic therapy, the normal intestinal microflora changes, so the likelihood of superinfection provoked by resistant microorganisms should be taken into account.

For children, to facilitate the administration of the drug, a suspension can be prescribed, the active substance of which is clarithromycin.

drug interaction

The drug can not be combined with taking cisapride, pimozide, terfenadine.

Cross-resistance between clarithromycin, lincomycin and clindamycin is possible.

The drug reduces the absorption of zidovudine, which requires compliance with the interval between doses for 4 hours.

Clarithromycin increases the blood concentration of drugs metabolized in the liver with the help of cytochrome P450 enzymes, indirect anticoagulants, carbamazepine, theophylline, astemizole, cisapride, terfenadine (2-3 times), triazolam, midazolam, cyclosporine, disopyramide, phenytoin, rifabutin, lovastatin, digoxin, ergot alkaloids and other agents.

They offer a great variety of medicines with different trade names. At the same time, the composition of some drugs is absolutely identical. A variety of generics and substitutes, supplemented with minor components and additives, are increasingly filling the shelves of pharmacy chains. Today you will find out which analogue of "Klacida" can be chosen. It should be clear right away that self-medication can be dangerous. Especially doctors do not welcome the use of antibiotics on their own whim.

"Klacid": instructions for use, reviews

The antibiotic is available in three forms. At your discretion, you can choose tablets, injections or suspension. The latter is more commonly used in children. The active substance of the drug - clarithromycin - refers to broad-spectrum antimicrobial agents, macrolides. The drug "Klacid" (tablets and suspension) is prescribed for bacterial lesions of the upper and lower respiratory tract, ENT organs, and also the skin. It is important that the microorganisms that caused the infection are sensitive to the active substance. So, for example, gram-negative bacteria that decompose lactose are resistant to the claimed drug.

Apply "Klacid" 250-500 mg twice a day. The duration of treatment varies from 5 to 14 days. For children, the drug is prescribed in an individual dosage, depending on age and body weight, under the supervision of a doctor. It is contraindicated to use the medicine for hypersensitivity, impaired renal function, pregnancy and lactation.

"Klacid" (suspension) - reviews say - has a pleasant taste. It is convenient that it can be given to children with milk. Such a drug costs about 400 rubles per 60 ml. Medicine in tablets (10 pieces of 250 mg) can be purchased for 600 rubles. Infusions - patients say - are prescribed quite rarely. The cost of an ampoule with a dosage of 500 mg is 650-700 rubles.

Inexpensive substitute for Clarithromycin

An analogue of "Klacida" can be found cheap. Many consumer reviews turn out to be negative only because of the price of the antibiotic. Not every person can afford to buy pills for almost 1000 rubles. There is a need to find a more affordable drug. This was Clarithromycin. It contains the same active ingredient as the original product. However, the cost of tablets is about 250 rubles. At the same time, there will be 14 pills in the package, not 10. Unlike the expensive American drug, this medicine is produced in Russia.

The indications of analogues are the same. The difference is that the domestic medicine can also be used to treat ulcers of the digestive tract, but in combination with additional medicines. This medication is not used in the same cases as its predecessor. It is unacceptable to give it to children under 12 years old. If you choose to purchase Klacid or Clarithromycin for a child, then the first medicine in the form of a suspension will have an advantage.

"Ekozitrin": a drug based on clarithromycin

What else can be found analogous? "Klacid" can be replaced with "Ekozitrin" tablets. Such a drug costs from 200 rubles. Each tablet contains 500 mg of clarithromycin and excipients. A medicine is prescribed for bacterial lesions of the ear, nose, throat, bronchi and lungs. It is used to treat skin infections and stomach ulcers. It is contraindicated to use "Ekozitrin" in case of renal failure, sensitivity, hypokalemia. The remaining contraindications coincide with the declared drug. The duration of treatment, unlike previous analogues, is 10-14 days. In some cases, it is advisable to take an antibiotic for six months.

"Sumamed": a popular analogue

"Klacid" or "Sumamed" - which is better? This question often arises in people who are at least a little versed in medicine. These two drugs are compared because they are both macrolides. The substances that make up the composition are different. The component of "Sumamed" is azithromycin. This medicine, as stated, is available in the form of tablets and suspensions. A solution for internal administration is produced, but it is practically not in demand. The cost of packaging "Sumamed" is approximately 500 rubles. The drug is prescribed for the same purpose as Klacid. Also, this analog can be used to treat genital infections.

If the doctor prescribes Klacid or Sumamed, which is better to choose? The last medicine is very popular. Also, its plus is that you need to take only one tablet per day. Unlike "Klacid", "Sumamed" is unacceptable to use during meals and even more so to mix it with milk.

Substitutes based on amoxicillin

If you have intolerance to the active ingredients of the Klacid drug, then you can choose a substitute with a different composition, for example, based on amoxicillin. This active substance belongs to the penicillin series of antibiotics. A popular representative is Flemoxin tablets. There are also trade names for drugs: Amoxicillin, Amosin, Ospamox, Ecobol and others. "Klacid" or "Flemoxin" - which is better to choose? The latter drug has its advantages and disadvantages:

• "Flemoxin" should be taken three times a day, and "Klacid" - two;
• penicillin antibiotic often provokes digestive disorders;
• "Flemoxin" - dispersible tablets (can be dissolved in water);
• This analogue costs about 350 rubles. for 20 pcs.;
• "Flemoxin" helps with gastrointestinal diseases caused by microorganisms sensitive to it;
• This medicine can be used during pregnancy and to treat babies.

Cephalosporin series

"Klacid" - tablets and suspension that can provoke an allergy. With this outcome, the medication is often replaced with antibiotics related to the cephalosporon series, a new generation. You can replace the claimed agent with drugs: Suprax, Cephalexin, Ceftriaxone, Cefatoxime, and so on.

These antibiotics inhibit the reproduction of bacteria by damaging their wall. Doctors say that only Cefalexin is absorbed from the gastrointestinal tract. Therefore, the rest of the drugs are prescribed for intravenous and intramuscular administration. If taken orally, there will be severe irritation of the mucous membranes of the stomach and intestines. The cost of the drug "Cefalexin" (16 tablets) is no more than 150 rubles. Affordable price is also important for the consumer.

Opinions formed about interchangeable medicines

If you decide to take an analogue of Klacida, then you must definitely discuss this with your doctor. All of the described drugs have a broad antibacterial effect. Perhaps this is the only thing that unites them. Cost, regimen, trade name and composition - that's how they differ. Some medications are often prescribed to children and expectant mothers ("Flemoxin"), others are prohibited drugs in pediatrics.

One of the widely used drugs is Clarithromycin, its analogues are semi-synthetic antibiotics from the group of macrolides. They are usually taken as prescribed by a doctor after testing for the sensitivity of the microbiota to certain types of substances. Clarithromycin preparations have several indications, for example, it helps with unspecified diseases of the upper respiratory tract. Analogues can be used in acute and chronic forms.

Medicines with this active substance are not recommended to be used on their own, because not all pathogens are sensitive to it, and in some situations the treatment will be ineffective. The drug has serious side effects but is generally well tolerated by children and the elderly. When prescribing it, no adjustment is required for cases where the patient's body is weakened by other diseases. The use of clarithromycin in kidney disease requires special care and attention from the attending physician. It is contraindicated during pregnancy and lactation.

For Clarithromycin, there is an instruction for use, analogues with this active substance have similar recommendations. Tablets in all analogues are coated with a special shell that allows the active substance to be delivered to the intestine, where it begins to be absorbed into the blood and enter into biochemical bonds. In order not to break the shell, a single tablet dose is swallowed whole with a small amount of liquid.

Clarithromycin is the internationally accepted name for the active substance. It has a wide spectrum of action on pathological microflora sensitive to this agent. In the pharmacy network, you can buy a large number of analogues with this active substance in the composition. Its advantage is that the drug is taken every 12 hours during the week. Such a schedule that is gentle on the intestinal microflora allows you to save the maximum number of beneficial microorganisms that suffer greatly when treated with other antibacterial agents.

All patented drugs have similar instructions for use, and they can be replaced by choosing a drug cheaper than other analogues.

The active substance clarithromycin is prescribed for the treatment of acute and chronic infectious diseases caused by Mycobacterium and chlamydia.

Analogues can be used for:

• purulent otitis media;
• sinusitis of any form;
• unspecified tonsillitis and pharyngitis;
• angina agranulocytic;
• acute laryngitis;
• tracheitis and bronchitis;
• pneumonia without specifying the pathogen.

Preparations containing clarithromycin may be prescribed for infections that affect the skin, purulent wounds. It is useful for the treatment of gastric and duodenal ulcers.

Trade names of patented medicines

Clarithromycin is one of the cheapest drugs among all analogues. It is produced in the CIS by many pharmaceutical companies, and it is no different from similar foreign products.

Popular, but more expensive is the drug Clarithromycin Teva, produced in the Republic of Croatia by Pliva Hrvatska.

The tablets of this analogue, like all others, are coated with a white film shell Opadry II 31F58914, approved for use in Russia. In addition to the active substance, Clarithromycin Teva contains auxiliary components:

• povidone;
• croscarmellose sodium;
• silicon dioxide colloidal;
• magnesium stearate.

Clarithromycin Teva is available in 250 mg and 500 mg doses. The package may contain 10 or 14 tablets (1 or 2 blisters).

The next common drug is marketed under the trade name Fromilid. It is manufactured by Krka, located in Slovenia. Fromilid can be bought in two forms. These are coated tablets containing 250 mg of the active substance for children over 6 years of age or 500 mg for adults. The blisters contain 5 tablets. One package may contain 5 or 10 tablets.

For children from 6 months to 6 years of age, the manufacturer offers a banana flavored suspension taken by mouth. For its preparation, granules are used, packaged in measuring bottles complete with a measuring spoon and instructions for use, which must be carefully read before using the medicine.

Klacid is another analogue in 500 mg tablets prescribed for adult patients. This is a long-acting drug, created through the use of two macrogols, 400 and 8000, which are responsible for the dissolution and absorption of the active substance in the intestine.

It is prescribed for persistent infectious diseases that are difficult to treat. The drug Klacid is often used to treat erysipelas.

When the drug is discontinued

All analogs that have the active ingredient clarithromycin can cause serious side effects. When they appear, the drug is canceled after consultation with the attending physician.

These can be allergic reactions in the form of skin rash, itching, malignant exudative erythema and anaphylactic shock.

The nervous system suffers from an antibacterial agent. Patients may feel dizzy, anxious, afraid. They sometimes suffer from insomnia or have frightening dreams. Very rarely, disorientation in space and confusion may occur.

Sometimes when taking the drug develops nausea, vomiting, diarrhea, stomatitis, glossitis. In rare cases, reversible hearing loss may occur.

All side effects are rare, and usually they are provoked by the intake of alcohol or other stimulant toxic drugs during treatment.

All such symptoms are discussed in the office of the attending physician, who corrects the prescription of medications.

Content

Many people are wary of antibiotics because of their intense effect on the body: disruption of natural defense processes, side effects that they can cause. Clarithromycin tablets are a new and safe macrolide drug. It has a deep effect and a minimum of negative consequences. Clarithromycin - instructions for the use of the drug, in which cases it is necessary to prescribe an antibiotic, doses for adult patients and children, what are the benefits of taking it, find out further.

What is Clarithromycin

The drug has an antibacterial effect against different types of microorganisms: anaerobic gram-negative and gram-positive, mycobacteria. Clarithromycin is the newest semi-synthetic antibiotic, an improved formula of erythromycin. It has high bioavailability, is stable under pH conditions, is rapidly absorbed into the intestine when taken orally, and disrupts the synthesis of the pathogen protein at the extracellular and intracellular levels. Be sure to read the instructions before use.

Indications for use Clarithromycin

The spectrum of action of the drug is very wide: it is active against chelonae mycobacterium and other mycobacteria, most species of the microorganism streptococcus. Clarithromycin differs from other antibiotics in that it can destroy bacilli and viruses at a deeper level, in tissue cells. Indications for the use of Clarithromycin are such diseases:

• respiratory infections of the upper respiratory tract (nasopharynx, paranasal sinuses);
• lower respiratory tract infections: bronchitis, pneumonia, pneumonia;
• infectious lesions of the skin and soft tissues (impetigo, furunculosis, erysipelas, infection of wounds);
• mycobacterial infections, staphylococci, streptococci, chlamydia, legionella;
• as an aid in tuberculosis;
• odontogenic infections (acute or chronic);
• with HIV infection;
• with a stomach or intestinal ulcer to combat the bacterium Helicobacter pylori.

What class of antibiotics does Clarithromycin belong to?

This is one of the most effective types of antibacterial drugs with mild side effects, a small number of contraindications. Clarithromycin belongs to the group of macrolides - the safest and most non-toxic antibiotics. Within this group, clarithromycin falls into the category of third-generation semi-synthetic drugs - supplemented, corrected versions of the active substance erythromycin.

Composition of Clarithromycin

The main active ingredient is clarithromycin. The tablets may contain magnesium stearate, talc, aerosil, starch, dyes, povidone. The composition of Clarithromycin is the secret of its hypoallergenicity: cases of allergy to the components are extremely rare, the antibiotic is also allowed for sensitive patients with intolerance to penicillin, which has been proven by clinical and laboratory studies.

Release form

Clarithromycin is sold packaged in cartons, blister packs or plastic containers of 7, 10 or 14 pieces, available in two volumes: 250 or 500 mg. The release form of the drug is tablets or capsules of a biconvex shape, covered with a whitish film coat. There are also oral suspensions and injection solutions - this form of the drug is more often prescribed to young children. The dosage is indicated in the instructions for use.

Instructions for use Clarithromycin

The dosage of the drug differs depending on the type of disease. Instructions for use Clarithromycin describes the doses and rules for use in various diseases. For infections of the upper respiratory tract, take 1 tablet of 250 mg 2 times a day. With Helicobacter pylori infection, ulcers, lesions of the intestines and 12-colon, the drug is used as part of complex therapy, combined with drugs such as Lansoprazole, Amoxicillin.

The dosage for the elderly is the same as for adults, oral only, but it is important to consider other drugs that the patient is taking and their compatibility with clarithromycin. Storage rules: keep it in a dry place, protected from moisture and sunlight, at a temperature not exceeding 25 degrees, away from small children. The standard shelf life is 3 years. Learn more in the instructions for use.

Instructions for use Clarithromycin for children

Antibiotic Clarithromycin has a good result in the treatment of pneumonia, sinusitis, pharyngitis, otitis media, inflammation of the respiratory tract in children of different ages. For adolescents 12-17 years old, the dosage is the same as for adults: twice a day, but in severe cases, the number of tablets per dose should not be increased. Instructions for the use of Clarithromycin for children depend on the dosage form: injections and suspensions are prescribed by the attending physician, depending on the disease, symptoms and condition of the child. The allowable dose for children is 7.5-15 mg per 1 kg of body weight per day, maximum 2 doses.

Overdose

Do not take more than 2 tablets of Clarithromycin at one time. One of the likely consequences of an overdose of an antibiotic is fever, pain in the abdomen or head, nausea, vomiting, diarrhea. In case of severe manifestations, it is necessary to call a doctor or an ambulance, medical procedures before overdose: gastric lavage or treatment of other symptoms. For more details, read the instructions.

Side effects

This antibiotic is considered safe and non-toxic, but each organism is individual and differs in a number of ways, so side effects may occur and continue for some time after the end of administration. Important factors are the presence of pathologies, diseases of the internal organs, which can provoke a reaction and sensitivity to the components of the drug. The following side effects of Clarithromycin are possible:

• Digestive system: diarrhea, vomiting, dyspepsia; gastritis, esophagitis, increased amount of bilirubin in the blood, pancreatitis, change in taste, color of the tongue, liver failure; very rarely - anorexia, loss of appetite.
• Allergies: skin rash, urticaria, dermatitis; anaphylactic shock, bullous itching.
• Nervous system: dizziness, confusion, insomnia, tinnitus; there may be a feeling of anxiety, disorientation.
• Skin: hyperhidrosis, sweating, acne, hemorrhage.
• Urinary system: discoloration of urine, nephritis, kidney problems.
• Muscles and bones: muscle spasms, myalgia, myopathy.
• Respiratory system: nosebleed, asthma.
• Recurrent infections: candidiasis, cellulitis, gastroenteritis, vaginal infections.
• Local reactions to injection: inflammation, pain at the injection site, phlebitis.
• General reactions: fatigue, chills, malaise, asthenia, drowsiness, tremor.

Contraindications

At later stages of pregnancy, while lactating and breastfeeding, it is necessary to consult a doctor, but it is better to stop taking it, since safety for the development of the fetus and child has not been established. Clarithromycin contraindications are allergic reactions to the components of the drug: they need to be diagnosed in advance, using special tests. It is forbidden to take pills for children under 12 years of age and for pregnant women during the first trimester.

It may be dangerous to take the drug if the patient has pathologies on the ECG, arrhythmia has occurred, there are liver diseases and kidney dysfunction, porphyria. In some diseases, doses may be reduced or the time between doses may increase. For small children (up to 6 months), the use of injections is not recommended, since their effect on a completely unformed body has not been studied.

Interaction with other drugs

Before you buy Clarithromycin, make sure you are not taking drugs that are incompatible with it. The active substance of the antibiotic has a strong effect, so the simultaneous use of clarithromycin and certain drugs is prohibited - this can cause unexpected, dangerous consequences for health. The attending physician should make the correct amounts of drugs and doses. To get the maximum effect from drugs, you need to limit their consumption. More information about interactions with other drugs:

• Forbidden: to combine Clarithromycin with Lovastatin, Simvastatin, Terfenadine, Cisapride, Astemizole.
• When taking the following drugs, it is necessary to adjust the doses (mainly reduce) because they suppress the action of each other: Rifabutin, Rifapentine, Phenytoin, Phenobarbital, Carbamazepine, Cisapride, Ritonavir, Zidovudine.
• Drugs that increase the concentration of 14-hydroxyclarithromycin (metabolite) and reduce the effectiveness of clarithromycin: Efavirenz, Etravirine, Nevirapine, Pimozide, Rifampicin.

Analogues

Most of the antibiotics from its group are considered similar, with the same or similar active ingredient in action. Another category is drugs used in the same cases as Clarithromycin, for the treatment of various diseases and viruses (for which Clarithromycin is used, read the instructions). Since the cost of the drug is high, many people choose affordable analogues, which, according to reviews, almost always have the desired effect. Consider drugs that are considered analogues of Claritomycin and the cases of their appointment to the patient:

1. Macrolides: Aziklar, Clerimed, Klabaks, Klarbakt, Klacid, Fromilid, Bayroklar, Arvicin, Clerimed, Ecocitrin.
2. By diseases: Vilprafen, Azitrox, Azitral, Hemomycin, Zitrolide, Zanocin, Rovamycin, Roxid, Azitro Sandoz.

Price Clarithromycin

The drug is inexpensive: 220-400 rubles, depending on the number of tablets. The course of therapy requires 2-3 packs of 7 or 10 capsules (see instructions). The price of Clarithromycin depends on the volume: 250 mg is cheaper than 500 mg and on the manufacturer: domestic firms are more profitable than European ones. The antibiotic is new, so price spikes can be extremely rare. The drug is distributed in pharmacies, it can be ordered and bought in an online store with delivery to a point of sale or home. Consider how much Clarithromycin 500 mg costs in web pharmacy catalogs:

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Attention! The information provided in the article is for informational purposes only. The materials of the article do not call for self-treatment. Only a qualified doctor can make a diagnosis and give recommendations for treatment, based on the individual characteristics of a particular patient.

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How to take the antibiotic Clarithromycin for adults and children - composition, indications, side effects, analogues and price