Does duphaston treat secondary infertility? Why is Duphaston prescribed for infertility? Contraindications for use

Not all women are able to have a child right away; in some cases, it takes several years. Duphaston - instructions for use when planning pregnancy indicate that the drug will be useful in the treatment of gynecological diseases, the threat of bleeding from the uterus, and is part of the treatment of infertility. The drug is taken in the first stages of planning conception and to maintain the health of the expectant mother during pregnancy.

In what cases should I take it?

During consultations, many doctors advise taking Duphaston for pregnancy. If you have any doubts regarding use, you can refer to the instructions that are included in each package of the medication. Infertility or difficulties in planning a conception are not the only reasons to take these pills. A girl can take Duphaston in the following cases:

• premenstrual syndrome;
• irregular menstruation;
• endometriosis (insufficient amount of the hormone progesterone);
• infertility due to luteal insufficiency;
• threatened or habitual miscarriage due to progesterone deficiency, which is confirmed by tests;
• dysmenorrhea;
• menstrual irregularities;
• secondary amenorrhea (treated together with estrogen therapy);
• dysfunctional uterine bleeding;
• Hormone replacement therapy (HRT): carried out to neutralize the effect of estrogens on a woman’s endometrium, which is associated with menopause (natural or surgical) with an infarcted uterus.

The main purpose for taking Duphaston according to the instructions is planning pregnancy for endometriosis, confirmed by tests that indicate a clear lack of the hormone progesterone. If you follow the rules of administration, a positive result will be noticeable almost immediately. Such dynamics can only be achieved if the woman follows all the rules of the medication treatment regimen.

How to take Duphaston when planning pregnancy

The instructions that are sold along with the drug contain a dosage regimen, but it is better if it is confirmed by your attending physician. Self-medication is not recommended, because therapy will be effective only with the correct dosage and frequency of tablet use. Taking duphaston when planning pregnancy is carried out according to the following rules:

1. Recommended use immediately after ovulation from 16 to 25 days of the cycle. You need to take the tablets at regular intervals several times a day. The course of treatment usually lasts at least 6 months.
2. If a woman started taking Duphaston when planning a pregnancy, then she needs to continue taking it after conception in the first stages of pregnancy to avoid miscarriage.
3. You need to take it until the placenta is formed, capable of independently providing the required level of progesterone. This usually happens between 12 and 16 weeks of pregnancy.
4. After conceiving a child, you need to drink the drug until week 20, then begin to reduce the dose (half or a whole tablet per week). You should not suddenly stop taking the drug, as this can lead to miscarriage.
5. An early conception will occur only if the drug is used according to the instructions.
6. Stop drinking Duphaston completely after 36 weeks.
7. If you miss taking a pill while planning to conceive, you must take the required dose within the next 6 hours.
8. There is no need to increase the number of tablets per day on your own, even if you missed taking it, to avoid an overdose.

Dosages of the medication indicated for use according to the instructions:

1. Infertility due to luteal insufficiency. You need to take 10 mg per day from days 14 to 25 of the cycle. You need to take the product for 6 cycles without breaks. In the future, use can be continued for 2-3 months after pregnancy.
2. Threatened abortion. You should take 40 mg of Duphaston once, then 10 mg every 8 hours until symptoms disappear.
3. Habitual abortion. Take 10 mg twice daily until week 20, then gradually reduce the dose.

Drug interactions

If Duphaston is taken simultaneously with inducers of microsomal liver enzymes, for example, rifampicin, phenobarbital, the metabolism of dydrogetesron may be accelerated, which will lead to neutralization of the therapeutic effect of the drug. No other cases of incompatibility with drugs have been recorded for this medication.

Composition of Duphaston

The medicine is produced in the form of biconvex, round tablets with beveled edges. There is a mark on one side, on each side of it there is an engraving 155. Available in blisters of 20 pcs. tablets. The composition of the drug is as follows:

Pharmacological properties

In its molecular structure, pharmacological and chemical properties, dydrogesterone is close to natural progesterone. This element is not a testosterone derivative and does not have the side effects that are inherent in almost all synthetic progestogens, which are also called androgenic progestogens. Dydrogetestrone has no glucocorticoid, anabolic, androgenic, estrogenic or thermogenic activity.

According to the instructions, Duphaston is part of a comprehensive HRT for menopause; the drug retains a beneficial effect on the blood lipid profile from estrogen. Unlike estrogen hormones, which negatively affect the blood coagulation system, dydrogestron has no effect on the coagulation rate. According to the instructions, the drug does not have a negative effect on liver function or carbohydrate metabolism when planning conception.

When taken orally, dydrogesterone selectively acts on the endometrium, this helps prevent an increased risk of developing hyperplasia or carcinogenesis due to excess estrogen. The medication according to the instructions is indicated for endogenous progesterone deficiency. Duphaston does not have a contraceptive effect, because it is used when planning pregnancy. The drug makes conception possible and ensures the maintenance of pregnancy during therapy.

Side effects

The drug is well tolerated during pregnancy and pregnancy planning, but in rare cases negative consequences of use appear. There are no cases of drug overdose reported in medical sources. If the dose is exceeded, gastric lavage is necessary. The following side effects are possible:

• migraine (headache);
• allergy symptoms (itching, skin rash, hives);
• liver dysfunction (jaundice);
• breakthrough bleeding from the vagina;
• increased toxicosis;
• increased fatigue, weakness, drowsiness;
• hemolytic anemia;
• excessive sensitivity of the breast (glands).

As a rule, Duphaston is well tolerated, but sometimes unpleasant effects may still occur, characterized by headache (migraine), liver dysfunction, allergy symptoms (skin rash, itching), breakthrough bleeding, which requires an increase in dose. Previously, no cases of drug overdose have been identified, however, when taking a dose that exceeds the required dose, it is worth performing a gastric lavage.

Contraindications

A doctor should prescribe the use of Duphaston after examination and diagnosis (if there are pathologies). The required dosage is determined based on the condition of the expectant mother. The drug is contraindicated when planning conception according to the instructions in the following cases:

• there are malignant tumors in the body;
• liver pathologies were identified;
• there are blood clotting disorders;
• in the presence of acute heart failure;
• in case of hypersensitivity to the components of the product;
• with type 1 diabetes mellitus;
• with a tendency to thrombosis;
• if there is serious damage to the liver or kidneys;
• while breastfeeding.

Duphaston for infertility is a drug that is prescribed if a woman has an imbalanced hormonal balance. This medicine is in very high demand on the market, since it has practically no contraindications, but at the same time it helps against most diseases that could cause infertility.

Application

Duphaston is considered a fairly good analogue of progesterone, containing a component whose molecular composition is very similar to dydrogesterone, which is similar to a natural hormone. It is indicated for those women who have previously had less than successful experience in treating this disease.

However, you should not even think about self-medication, even if you strictly follow the attached instructions, since this drug can only be prescribed in a certain dosage depending on the individual characteristics of women in order to cure the disease and maintain the normal condition of the expectant mother. The hormonal background and general condition of the woman will show whether it is necessary to take it at all.

In order for the pregnancy to proceed successfully and not cause any complications, there is a need to comply with certain features. The condition of the endometrium greatly influences how the fertilized egg will be attached and whether it will be attached at all, as well as whether the endometrium will interfere with the normal nutrition of the baby.

The condition and further development of the fetus strongly depends on the corpus luteum. But the most important factor is the presence of normal, balanced hormonal levels, which can then help prevent rejection and the subsequent death of the child.

Most often, Duphaston eliminates infertility and other problems.

It must be taken in the following cases, which can be found in the instructions:

1. For endometriosis.
2. In case of insufficiency of the corpus luteum in the luteal phase.
3. For disturbances in the course of the menstrual cycle.
4. With insufficient amounts of your own hormone - progesterone.
5. In case of a possible miscarriage.

The most important thing to remember is that the dosage is prescribed by the attending physician, since he is a specialist in this profile, and the patient, having read any articles on the Internet, can simply harm herself. Moreover, we are talking about hormones, which are generally better not to mess with.

Progesterone performs several functions during pregnancy that contribute to its normal course. Firstly, it begins to extinguish male hormones found in the female body. And secondly, it helps improve the woman’s immune system, which can perceive the fetus as a foreign object and try to get rid of it. It is precisely because of the lack of this hormone, or rather the failure to fulfill this function, that spontaneous delivery is most often observed in the early stages of pregnancy.

The instructions for use advise taking the drug after the end of ovulation and before the start of the menstrual cycle.

Treatment with this drug lasts six months. Even if a woman was able to conceive a child, it is not recommended to stop taking this medication, since it can prevent the threat of miscarriage, which is undesirable in case of infertility.

Efficacy and side effects

Like many other drugs, Duphaston treats infertility and other pathologies, but has a number of side effects that every patient taking it can experience. Its use is not possible during breastfeeding, as well as in case of individual intolerance to some components of the medication.

Side effects include:

• Feeling nauseous;
• Vomit;
• Liver diseases;
• Lumps in the chest area;
• Bleeding;
• Feeling weak;
• Migraine;
• Skin rashes, swelling and itching sensations.

However, even despite the above-mentioned factors, the drug itself is in great demand, and its effectiveness has shown everyone that Duphaston has more advantages than disadvantages for infertility. However, there is no need to use it without a doctor’s recommendation, since the severity of infertility requires a different approach to its treatment, and this is also why the choice of medications follows.

The reviews left by patients after taking this drug did not indicate whether there were cases of overdose, but experts urge gastric lavage to avoid any risk.

The drug itself is produced in the Netherlands. To preserve it for a longer period of time, it is recommended to keep it in a dry place at a temperature not exceeding 30°C.

Some patients taking Duphaston for infertility experienced breakthrough bleeding. If this happens, then it is worth increasing the dose used, although this should only be done with the consent of the attending physician.

There is a need for observation by a specialist who has taken up the treatment of a woman if she has discovered tumors that are affected by this drug, causing them to grow and develop. Such a tumor can become a meningioma. Duphaston for infertility has helped many, so you should not stop treatment with this drug in this case, however, infertility should not force you to take extreme measures, and therefore it is better to periodically visit a doctor who can monitor the patient’s condition.

Duphaston does not have any effect on human behavior while driving a car or other vehicles.

The shelf life of the drug is 5 years from the date of production. It is not recommended to take this medicine if it has expired.

Infertility is not a death sentence. The main thing is not to lose self-confidence and the desire to correct the situation, get cured, get pregnant and give birth to a healthy child. Correctly selected treatment will help you get rid of such a scourge and find your feminine happiness. Duphaston will solve problems with conception and pregnancy. Those who have already been helped by the drug are happy and recommend its use.

Quite often a person finds himself in a situation where he needs to take certain medications. Hormonal drugs are in most cases prescribed to representatives of the fairer sex. It is their body that undergoes cyclical changes every month. One of the most popular prescribed drugs is artificial progesterone. It is worth considering in detail how to take Duphaston.

How does the female body work?

Every month a woman begins a new cycle. It consists of two phases: first and second. The cycle is divided into parts by the day when the egg is released from the ovary.

In the first part of the month, the woman’s body releases hormones that are necessary for the proper growth of the egg and the preparation of the uterine layer for pregnancy.

The second phase is called the luteal phase. During it, a strong release of the hormone progesterone is observed. It is he who is responsible for the normal course of pregnancy in the event of fertilization. The drug "Duphaston" is an artificial substitute for progesterone.

When is this medicine prescribed?

The doctor prescribes Duphaston tablets only after a preliminary examination. It can be recommended to a woman in the following cases:

It is worth noting that it is always necessary to comply with the prescribed dosage and treatment time.

How to take Duphaston?

Depending on the diagnosis given to the woman and the cause of the illness, an individual dose of the drug is selected. Also, the dosage and time of taking the drug may vary. Let's look at how to take Duphaston correctly for a particular disease.

During the threat of spontaneous miscarriage

If a pregnant woman is at risk of miscarriage, then in most cases she is prescribed this particular remedy. The doctor decides how to take Duphaston in this case. It all depends on the severity of the symptoms and the cause of their occurrence.

In most cases, the patient is prescribed a single dose of four tablets, which is forty milligrams of the drug. After this, it is recommended to take one capsule every eight hours. This must be done until the symptoms disappear completely: pain, bleeding, feeling unwell.

If a woman is at risk of miscarriage due to a lack of progesterone in the body, then how to take the medicine in this case? Usually the doctor prescribes two tablets per day, which must be taken at equal intervals. It is worth noting that in such a situation, the treatment time with Duphaston increases significantly. A specialist will tell you how long you can take it. In most cases, such treatment is prescribed before the beginning of the second trimester of pregnancy, when the placenta completely takes over the production of the necessary hormone.

Duphaston tablets for infertility: how to take?

Quite often, this drug is prescribed to women planning pregnancy. If a representative of the fair sex has regular sex life without using contraception, but conception does not occur, then she should consult a doctor. The first symptom of a second phase deficiency is its short length. After testing for the required hormone, the doctor may recommend taking it additionally.

So, how to take Duphaston to get pregnant? In most cases, the medication is prescribed one tablet per day. You need to drink them from the 14th day after the start of your last period until the 25th day. However, when prescribing this, it is worth remembering that this regimen is only suitable for women with a regular cycle of 28 days. If you have a longer cycle, you can only take additional progesterone after ovulation. Otherwise, you may achieve the opposite contraceptive effect. Taking Duphaston before the egg leaves the ovary can simply suppress it.

For hormonal diseases

Very often, for various pathologies associated with improper production of hormones, progesterone is prescribed. One of the treatment options may be the prescription of Duphaston tablets for endometriosis. How to take the medicine in this case depends on the severity of the symptoms of the disease and the stage of the disease.

As a rule, doctors adhere to the following scheme. The patient is prescribed to take one capsule two to three times a day. The duration of treatment is 11 days: from the 14th day from the beginning of the last menstruation to the 25th.

For a more serious stage of the disease, the doctor may prescribe continuous use of the drug. In this case, the woman needs to take one pill twice a day. Reception should be carried out at regular intervals. Only in this case can the maximum effect of treatment be achieved.

For female cycle disorders

If a representative of the fair sex experiences irregular menstruation, she may also be prescribed an additional dose of progesterone. In case of severe premenstrual syndrome, the doctor may recommend the use of Duphaston tablets.

In these cases, the drug is prescribed from the 11th day from the beginning of the last menstruation. The course of taking the drug should continue until the 25th day of the cycle. You need to take the medicine one tablet 2 times a day at equal intervals.

In case of prolonged absence of menstruation (amenorrhea)

How to take Duphaston if a woman does not have periods, but this is not related to pregnancy? In this case, the use of this medicine is prescribed from 11 to 25 days of the cycle. It is imperative to supplement treatment with medications containing estrogens.

For bleeding of unknown origin

To stop bleeding, the drug Duphaston is prescribed for one week. You need to take it twice a day, one capsule. Before prescribing the drug, it is necessary to establish the cause of such discharge.

To prevent dysfunctional bleeding, it is prescribed to take one capsule twice a day during the menstrual cycle - from 11 to 25 days.

With hormonal replacement therapy (after removal of the ovaries)

If a regimen in combination with estrogens is chosen, then one drug is prescribed in the first two weeks. In the next two weeks, you need to take Duphaston tablets.

If taking estrogen is contraindicated, then only artificial progesterone is prescribed for two weeks, after which it is necessary to take a break for 10-15 days.

The dosage of the drug in these cases is 10 mg, that is, one capsule per day.

In case of tumor processes in the female body

If a woman has cysts on the ovaries or other organs, then how to take Duphaston in this case?

If the tumor is estrogen-dependent, which is most often the case, then the medicine is prescribed two tablets per day throughout the entire cycle. The goal of treatment in this case is to suppress the production of estrogen.

Correct selection of drug dosage

Usually this medicine is available in the following form: in a cardboard box there is a plate with 20 tablets. One pill contains 10 milligrams of the drug. But in some cases, you may find a higher dosage of 20 milligrams. You must always pay attention to this, since in this case it is necessary to take Duphaston tablets according to a different scheme.

Conclusion

If you are prescribed the drug Duphaston, you must adhere to the selected course of treatment. In each individual case, the regimen for using the drug must be individual. Otherwise, you will not get an effective result from the hormonal treatment.

Before prescribing the drug, a preliminary examination should always be carried out. It is also necessary to take into account the duration of the female cycle.

Monitor the state of your hormones and carry out the necessary treatment on time. Be healthy!

The important functions of progesterone are strongly associated with a woman's health and successful pregnancy.

Among the main functions of the hormone are the effects on:

When are progesterone drugs used for treatment?

The problems that prevent a woman from getting pregnant are very different. For this reason, medications are also prescribed by the doctor depending on the disease.

If there is a malfunction in a woman’s endocrine system and the concentration of the hormone decreases, additional progesterone must be taken. Main Indications for taking this drug are the presence of the following diseases or conditions:

• algodismenorrhea (very painful menstruation), amenorrhea (lack of menstruation);
• uterine bleeding;
• risk of abortion;
• infertility, which is caused by insufficiency of the corpus luteum;
• mastodynia (chest pain) or mastopathy changes.

What types of drugs are there and how do they differ from each other?

Hormonal preparations that contain this hormone have different structures, for this reason the choice of drug is individual.

All products containing progesterone are divided into two groups:

1. With natural progesterone.
2. With synthetic.

Natural affects the corresponding receptors without producing an estrogenic or androgenic effect. But such drugs are weaker than synthetic ones.

Synthetic ones are more active than natural ones, but they affect estrogen and androgen receptors, causing additional symptoms. Also, depending on the dosage, such drugs can shrink or thicken the endometrium, and in some cases even suppress it.

If you do not delve into the composition, features and properties of Duphaston and Utrozhestan, it may seem that there are no differences. However, it is not. Of course, the prescription of drugs should be done by a doctor, who will select the medicine in accordance with the characteristics of the woman.

Duphaston

Available in tablet form. Duphaston contains dydrogesterone, which is close to natural progesterone. Affects the endometrium, preventing its hyperplasia. The therapeutic effect is achieved without suppressing ovulation or disrupting menstrual function. Rarely causes side effects. Among the advantages of the drug, the following should be highlighted:

• when planning IVF, Duphaston is most often prescribed;
• it does not harm the fetus and protects the woman from premature birth;
• after taking the drug there are no unwanted hairs or pimples;
• reduces the risk of placental insufficiency;
• does not affect liver function.

Utrozhestan

The drug is considered an analogue of Duphaston. The main difference from the first drug: it is identical to the corpus luteum hormone; it is an almost completely natural remedy. Among the positive impacts it should be noted:

• decreased excitability and contractility of the muscles of the fallopian tubes and uterus;
• promotes the formation of normal endometrium;
• does not disrupt metabolism, does not increase blood pressure.

Duphaston and Utrozhestan are drugs that are widely used during pregnancy. However, when taking Duphaston, uterine bleeding may occur. And the list of side effects when taking Utrozhestan is more extensive:

• sudden mood swings;
• dizziness;
• drowsiness;
• presence of low-grade fever (37°C).

Important! Duphaston and Utrozhestan should not be used if there is an individual intolerance to the components, as well as liver pathologies (Dabin-Johnson and Rotor syndromes), if there are malignant tumors, a tendency to form blood clots, allergic reactions and severe liver dysfunction.

Other synthetic drugs include the following:

1. Progesterone– an injectable dosage form of the hormone. Usually used during pregnancy when there is a threat of miscarriage.
2. Krinon― this is a gel that increases the amount of progesterone. It is administered intravaginally. The content of the active substance in the gel is about 80%.
3. Ingesta– a means for intramuscular administration. Prescribed for delays and irregularities in the menstrual cycle. The course of treatment should be about 2 weeks, 1 injection per day. After which the dosage can be increased by 1.5 times.

What do doctors most often prescribe?

Most often, doctors prescribe two drugs: Utrozhestan and Duphaston. This is due to the low number of side effects and widespread effectiveness. If we talk about Utrozhestan, then it also contains natural progesterone.

In any case, when prescribing a particular drug, the doctor is guided by the individual characteristics of the woman, which are clarified after testing.

Contraindications for use

Medicines containing progesterone for systemic use are contraindicated if the patient:

• increased sensitivity of the body to the composition of the drug;
• impaired renal and liver function;
• predisposition to thrombosis;
• thromboembolic complications;
• vaginal bleeding of unknown origin;
• oncopathology.

How to take and cancel: dosage regimens

Depending on the length of the menstrual cycle (usually 28 days), gynecologists prescribe progesterone drugs and determine the dosage regimen.

The most common regimens are presented below, but they may vary depending on the reason for the prescription, so it is extremely important to take the drugs strictly as prescribed by the doctor.

Thus, the regimen for taking such drugs is determined by the doctor, since independent prescriptions pose a health threat.

Treatment results

With a diagnosis such as infertility, it is impossible to talk about a certain percentage of successful or unsuccessful treatment, since this diagnosis is very broad. Women with the same medical conditions may have different effectiveness when taking progesterone, since everything is individual.

It should be said that the success of infertility treatment depends on the results of the examinations and tests performed, the professionalism of the attending physician, the woman’s lifestyle and the severity of established diseases.

To summarize, it must be said that in most cases, hormonal therapy helps women overcome infertility and bear a baby. You should find a good specialist who will help you choose progesterone preparations in accordance with the characteristics of the woman’s body.

Infertility occurs due to a wide variety of reasons. Most often, infertility can be caused by hormonal imbalance.

Duphaston is a stereoisomer of progesterone, which is obtained as a result of prolonged ultraviolet irradiation of progesterone. If hormonal imbalances occur and, as a result, there is a lack of sex hormones, the doctor may prescribe duphaston for infertility.

Sex hormones stimulate the maturation and release of the egg from the follicle. With a lack of these hormones, ovulation usually does not occur. When there is not enough progesterone, even after fertilization has occurred, the egg moves into the uterus with great difficulty, and it will be very difficult for the fertilized egg to gain a foothold in it.

How to take the drug

If there is a lack of progesterone, duphaston for infertility is prescribed from the 14th to the 25th days of the menstrual cycle. Duphaston is taken for 3-6 cycles, which follow each other. When pregnancy occurs, duphaston is continued to be taken up to 16 weeks, or sometimes the drug can be extended to 24 weeks.

The dosage is calculated for each woman individually. The daily dose is divided into two doses.

If there is a threat of miscarriage, the dose per day can be increased to an individual norm, taking into account the patient’s condition.

After taking the drug within the periods indicated above, the placenta begins to produce all hormones, so the drug is stopped.

Duphaston for infertility helps maintain ovulation without having a negative effect on progesterone that forms in the placenta during early pregnancy.

Contraindications for use

- should not be taken by those who are allergic to the components of the drug;
- It is not recommended to take it during lactation, since dydrogesterone can penetrate into the blood, and therefore into milk.

By and large, duphaston for infertility does not show pronounced side effects. The drug is well tolerated. Sometimes headaches or itching of the skin may occur.

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