Meldonium is harmful to the body. The effect of meldonium on the body, benefits and correct intake

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The well-known drug Mildronate, widely used by athletes and older people, was recently added to the anti-doping list of drugs, which caused many scandals in the sports community. How dangerous the drug is, how to use it correctly, as well as the harm and benefits of mildronate for the body - all this should be known to those who have been prescribed this medication.

Initially, the medicine was used to treat heart diseases that arose as a result of high energy consumption, as well as when the body was weakened. However, it was most often used by relatively healthy people, people involved in sports, as well as those who wanted to lose extra pounds.

The product is available in the form of capsules, liquid for injection, and also in solid dosage form. The main component is meldonium, a compound found in the cellular structures of the human body.

The drug promotes the onset of complex chemical processes in the body and acts as follows:

increases the body's endurance, increases performance;
has a positive effect on the state of tissue immunity;
promotes mental and physical stability under severe stress;
reduces the load on the heart.

Thus, the effect of mildronate on the body is predominantly positive. The medicine quickly delivers oxygen to cells and tissues, cleanses organs of toxins and metabolic products, and also protects them from destruction.

With regular use of the product, the human body is able to withstand intense stress for a long time and recover quickly. All these features make it possible to use it both in therapy and in the prevention of various disorders of the heart, blood vessels, as well as in cases of circulatory disorders in the brain.

Mildronate has shown greater effectiveness in ischemic disease due to its ability to slow down cell death and accelerate the regeneration process. In addition, in case of heart failure, the medicine increases the contractility of the myocardium and makes the body more resistant to physical stress.

Purchasing the product in pharmacy chains is currently not a problem. It is often used in the complex treatment of the following diseases:

pathologies of the heart and blood vessels, ischemia, heart attack;
inflammatory processes in the muscle tissue of the heart;
circulatory disorders in the brain of a chronic and acute nature.

Other indications for use are:

deterioration in performance;
rehabilitation period after surgery;
excessive physical stress;
some diseases of the retina, for example, hemophthalmos;
bronchitis and asthma. In these cases, mildronate is used as an immunomodulatory drug.

The therapeutic abilities of the product allow it to be used in professional sports, as well as for healthy people who need additional help in combating physical stress. In these cases, medications containing meldonium are ideal:

Mildronate effectively increases the capabilities of the human body, increases stability and increases the dynamic activity of athletes;
a positive effect of the product on the effectiveness of training has been noticed: thanks to the active nutrition of the muscular system and heart, it relieves fatigue, which significantly increases the duration of approaches;
lost energy is restored much faster, while metabolic products are released from the organs more intensively;
the effect of the substance was established during strength exercises during training, as well as during stress on the heart.

It is worth noting that the drug is not a doping drug in the literal sense of the word, and does not lead to muscle growth. Its effect is precisely to relieve fatigue and increase endurance.

The substance included in the composition is often used in complex removal of excess body weight. However, it cannot be used as an independent drug for weight loss. Meldonium helps speed up metabolism, recovery processes in the body, and also reduces the amount of cholesterol. This allows a person to quickly adapt to exercise, which leads to weight loss. That is why, combining mildronate with sports, you can quickly lose extra pounds.

Proper use of the medication is a guarantee of excellent results, but it must be prescribed by the attending physician.

Systematic use of the drug may result in a decrease in its therapeutic effect, which is why the patient should carefully follow the recommended regimen:

the medicine is usually taken before 5 pm: the ingredients it contains increase excitability and can negatively affect sleep;
for medicinal purposes, mildronate is prescribed 500-1000 mg twice a day;
The duration of treatment depends on the individual characteristics and goals pursued, and most often lasts up to 12 days.

Amateur athletes take 0.5 g per day for 2 weeks, after which they take a break for 14 days and repeat the therapy. For professionals, the dosage is 1 g per day.

The downside of using the drug is addiction. Long-term use can negatively affect the psycho-emotional state of athletes.

Is mildronate harmful? This question worries not only people involved in sports, but also ordinary people. It has been established that the drug does not have a destructive effect on the body, unlike other doping agents. However, like any medicine containing meldonium, the medicine has side effects, which, however, occur quite rarely.

The main conditions for the effectiveness of the drug are compliance with the dose and duration of use.

After using mildronate, the following negative consequences have been established:

allergic skin rashes, swelling. Most often observed with intramuscular use of the drug;
dyspepsia, heaviness in the abdomen, vomiting, nausea, heartburn;
increased heart rate, which manifests itself during emotional arousal;
decrease in blood pressure readings.

To avoid overdose and other negative consequences, when purchasing a product you should pay attention to the dosage: the drug is available in 250 and 500 mg doses.

Mildronate is prohibited for use by children under 18 years of age, during pregnancy and breastfeeding, as well as in the following cases:

with excessive sensitivity to the components of the drug;
for severe kidney disease;
with liver failure;
with swelling of unknown etiology;
with increased ICP caused by malignant neoplasms.

The opinion of most doctors boils down to one thing: mildronate is a harmless and useful remedy that allows you to protect the body under any type of stress. Most often used as a symptomatic drug when a temporary increase in performance is necessary.

Anti-doping control officially banned the use of the drug in early 2016. Identification of the use of Mildronate for non-therapeutic purposes may lead to the disqualification of athletes. Typically, these tablets are prescribed by a neurologist or cardiologist to strengthen the heart, increase endurance, and restore general tone. People who took the drug noted an improvement in their condition after just a few months of course use.

Whether to buy a product or not is not a decision you should make on your own. Only a qualified specialist determines the need to take mildronate and determines the optimal dosage.

Athletes and older people have been familiar with a drug such as Mildronate (or Meldonium) for many years. However, most Russians became interested in the properties of the drug only now, in connection with the sensational investigations of a number of anti-doping agencies in the media. Initially, Mildronate was intended to combat heart problems that arise against the background of increased energy costs or wear and tear of the body. Today, the drug is often used by healthy people, athletes and those who want to lose weight.

Today Mildronate is available in three dosage forms:

Gelatin capsules in two sizes.
Injection.
Pills.

In all cases, meldonium is the main active ingredient. It is an analogue of a component that is part of every cell of the human body. Taking Mildronate leads to the launch of many chemical reactions and the following results:

Improving the body's performance indicators, increasing efficiency.
Increasing humoral (carried out through liquids) and tissue immunity.
Dulling of the reaction to psychological and physiological stress.
Cardioactivity protection.

Thanks to these properties, the drug can be used in young, mature and elderly people to improve heart function. The medicine is also useful for athletes and people forced to experience severe physical and emotional stress.

The therapeutic properties of Mildronate appear depending on the purpose for which it is planned to be used.
The main effects that can be expected during drug treatment are as follows:

In case of heart failure, the strength of contractions of the heart muscle increases, thus reducing the risk of an angina attack; in addition, meldonium increases the body's resistance to physical stress.
If there is damage to the myocardium, the rate of formation of areas with signs of necrosis decreases and, accordingly, the rehabilitation period is shortened. At the same time, blood circulation in the damaged, ischemic area significantly improves.
If a person experiences increased physical activity, Mildronate restores the normal supply of oxygen to cells, prevents the accumulation of toxins and waste products of cellular metabolism, increases the stability of cells and their structures, and prevents their excessive destruction. As a result, the speed of metabolic processes increases and the body recovers faster.

Advice
The majority of reviews about the use of the drug based on meldonium are positive. But the required result of therapy is possible only with the correct dosage, which is prescribed individually. Before taking Mildronate, you should be examined by a cardiologist and agree with him on the specifics of taking the drug.

Mildronate also has a tonic effect on the central autonomic nervous system. This is often used to eliminate disorders that have arisen against the background of withdrawal syndrome (due to chronic alcoholism).
The drug is also used in ophthalmology. It helps improve visual acuity due to its positive effect on the small vessels that supply the retina with blood.

These positive effects reach their maximum severity when using the injection solution. Tablets can show up to 78% of its effectiveness. Regardless of what form of medication is used, its breakdown products will be excreted by the kidneys. They do not have any toxic load and do not harm the excretory organs.

The drug is contraindicated in children and adolescents under 18 years of age. The effect of meldonium on a woman’s body during pregnancy and lactation has not been fully studied; its use during these periods should be avoided.

Mildronate tablets and capsules are prescribed in the following cases:

ischemic disease, as part of complex therapy;
vascular diseases, in particular, the periphery of the arteries;
physical, mental and emotional stress;
the need to speed up the rehabilitation process after surgery or long-term treatment;
chronic heart failure;
chronic pain in the heart in the absence of obvious pathology;
obstructive pulmonary conditions (bronchitis, asthma, emphysema) of a chronic type;
rehabilitation after stroke;
chronic alcohol dependence, in complex treatment.

The injection solution can be used for all of the above conditions. Apart from this, it is additionally used in the following cases:

hemophthalmos (blood entering the vitreous body of the eye) of total, subtotal and partial type;
retinal hemorrhage;
damage to the eyeball, dilation of blood vessels on its surface;
the formation of blood clots, leading to impaired vascular patency as a result of pathological processes in the central branch of the retina.

Even if one of these diagnoses was made by a specialized specialist, you do not need to independently prescribe Mildronate in any of its forms. It is necessary to agree on the dosage and frequency of administration with the doctor, to make sure that there are no contraindications to specific therapy.

Meldonium is often prescribed in combination with other medications to enhance their therapeutic properties. Most often they are accompanied by diuretics, bronchodilators, anticoagulants and antiplatelet agents. In this case, you need to carefully monitor your condition and inform your doctor about any reactions from the body.

Today, Mildronate is increasingly being taken by healthy people, but even in this case, you must first consult a doctor. Professional and amateur athletes show particular interest in the drug. At some point, their body stops coping with physical stress. To maintain his strength, medications based on meldonium are ideal.

Mildronate expands the capabilities of the body, improves its performance, and increases results. This applies to both static and dynamic activity.
The effectiveness of sports training increases because the drug stimulates the nutrition of muscles, including the heart, with beneficial substances. At the same time, fatigue is relieved, which allows you to increase the duration of approaches.
Despite the fact that heart function improves, Mildronate is not a doping in its direct sense. Taking it does not increase the athlete’s muscle mass; it simply gives them the endurance necessary to gain it properly.
The body's energy reserves are restored much faster than usual. This occurs due to the fact that metabolic products are removed from the cells much more actively.
The effectiveness of Mildronate is obvious both during strength and cardio exercises that train endurance.

In addition, meldonium is often used in a set of measures aimed at losing excess weight. In no case should meldonium be considered as an independent means for losing weight. The substance accelerates metabolic and recovery processes, reduces cholesterol levels, and this allows the body to more actively adapt to the physical activity necessary for weight loss. Thus, the combination of Mildronate and sports can be optimal for achieving an ideal body.

The rules for taking the drug for men and women are the same and are determined by the characteristics of the drug.

The therapy schedule should be designed so that Mildronate is taken before 17.00. The components of the composition increase the excitability of the body, which can negatively affect the mode of work and rest.
For therapeutic purposes, the drug is prescribed at a dose of 500-1000 mg 2 times a day. The duration of the course depends on the type of pathological condition and is usually maintained within 12 days or 4-6 weeks.
Amateur athletes are recommended to take Meldonium 500 mg per day. Course duration – 2 weeks. Then a break is taken for 2-3 weeks, and the course is repeated. For professionals, the single dose and frequency of administration can be doubled.

It is important to understand that continuous use of Mildronate may lead to a decrease in its effectiveness. Therefore, you should not chase quick results; you should strictly adhere to the regimen recommended by your doctor.

Like any medication, meldonium-based drugs have their drawbacks. These include a fairly long list of side effects, although they rarely occur if the rules of administration are followed.

Allergies in the form of skin itching, swelling, rash. Most often it happens when the solution is administered intramuscularly.
Dyspeptic disorders in the form of belching, vomiting, heartburn, nausea, heaviness in the stomach.
Tachycardia against the background of emotional excitement.
Reduced blood pressure.

The drug is contraindicated in children under 18 years of age, pregnant and lactating women, as well as people who have:

Hypersensitivity to the components of the drug.
Pathologies of the kidneys and liver up to chronic failure.
Increased intracranial pressure, including due to tumors.
Edema of unknown nature.

Mildronate is available without a prescription. When purchasing the drug, you need to pay attention to its dosage (250 or 500 mg) to avoid overdose.

One hard gelatin capsule of Mildronate contains 250 or 500 mg Meldonia in the form of a dihydrate as an active component and excipients: Amylum solani (potato starch), Silicii dioxydum colloidale (colloidal silicon dioxide), Calcium stearate (calcium stearate).

To make the gelatin shell, Gelatinum (gelatin) and Titanium dioxyde (titanium dioxide) are used.

One milliliter of injection solution Mildronate contains 100 mg Meldonia and water for injection as an auxiliary component.

One Mildronate tablet contains 500 mg Meldonia in the form of phosphate and auxiliary components: Mannitum (E421; mannitol), Povidonum K-29/32 (povidone K-29/32), Amylum solani (potato starch), Silicii dioxydum (silicon dioxide), Cellulose microcristalline (microcrystalline cellulose), Magnesium stearate (magnesium stearate).

The drug Mildronate is produced by the manufacturer in the form:

clear colorless solution for injection;
hard gelatin capsules No. 1 and No. 2, filled with hygroscopic white crystalline powder. The powder contained in the capsules has a weak characteristic odor and a sweetish taste (the capsule itself has a neutral taste);
tablets Mildronate Gx 500 mg (tablet taste slightly sour).

The solution is sold in 5 ml ampoules (500 mg/5 ml). One cardboard package contains: 2 blister packs with 5 ampoules of Mildronate in each and instructions for use of the drug.

Capsules are packaged in blisters of 10 pieces each. One cardboard box contains 4 blisters and instructions for use of the drug.

Meldonium is a synthetic drug that has a similar effect to γ-butyrobetaine (GBB; a substance that is a precursor to hydroxytrimethylaminobutyric acid, a natural vitamin-like substance related to B vitamins).

According to Wikipedia, meldonium characterized by the ability to improve metabolism and energy supply to cells and is used as:

cardioprotective;
antihypoxic;
angioprotective;
antianginal means.

Mechanism of action Meldonia determines a wide range of its pharmacotherapeutic properties. Taking this drug helps improve performance, reduces the severity of manifestations of mental, intellectual and physical stress, activates tissue And humoral immunity.

In patients suffering from heart failure, increases the strength of contractions heart muscle, reduces frequency heart attacks(attacks angina pectoris), and also increases the body's tolerance to physical activity.

For acute injuries myocardium application Meldonia slows down the formation of necrotic areas, shortens the duration of the rehabilitation period, normalizes blood circulation in the area of ischemic damage and redistributes blood in favor of the ischemic area.

Under conditions of increased loads meldonium helps restore the balance between the transport of oxygen into cells and the cells' need for it, prevents the accumulation of cellular metabolic products and toxic substances in cells, protects cells and cellular structures from damage, ensures the body quickly compensates for its energy reserves and maintains the highest rate of metabolic processes.

Toning CNS, meldonium effectively eliminates functional impairments somatic and autonomic (autonomic) parts of the nervous system, including violations that accompany withdrawal syndrome in patients suffering from chronic alcoholism.

In addition, the substance has a beneficial effect on the condition dystrophically altered retinal vessels, which allows it to be used for treatment vascular and dystrophic pathologies of the fundus.

The action of the active substance of the drug is aimed at inhibiting the enzymatic activity of γ-butyrobetaine hydroxylase, which is the last enzyme in the chain reaction of synthesis L-Carnitine.

Meldonium helps reduce the concentration of free carnitine, interferes with transportation through cell membranes long chain fatty acids, prevents the accumulation in cells of activated forms of unoxidized fatty acids, which are derivatives acylcarnitine And acyl coenzyme.

In ischemic tissues, it restores the balance between the transport of oxygen and its absorption by cells, prevents disruption of the transport of adenosine triphosphate, while simultaneously activating glycolysis, which occurs without additional oxygen consumption.

The result of a decrease in concentration carnitine is the enhanced synthesis of the vasodilator γ-butyrobetaine.

After taking the Mildronate tablet per os, it contains meldonium quickly absorbed in the digestive tract. The drug is characterized by a fairly high bioavailability index. The latter is approximately 78%.

Concentration Meldonia V blood plasma reaches its maximum values an hour or two after administration. In organism meldonium metabolized to non-toxic products - glucose, succinate, 3-hydroxypropionic acid.

Metabolites are removed kidneys. The half-life (T½), depending on the characteristics of the particular organism and the dose taken, can range from three to six hours.

The drug in injection form is characterized by 100% bioavailability. Concentration Meldonia V blood plasma reaches its maximum values immediately after administration of the drug. The half-life (T½), depending on the characteristics of the particular organism and the dose taken, can range from three to six hours.

The result of metabolization Meldonia is the formation of non-toxic metabolites (glucose, succinate, 3-hydroxypropionic acid), which are then excreted from the body kidneys.

All dosage forms of the drug are intended for the treatment of adult patients.

Indications for use of Mildronate (for all dosage forms of the drug):

IHD(in combination with other medications and treatments);
peripheral artery disease;
reduced performance;
encephalopathy;
physical overload (including in sports);
postoperative period (to speed up the recovery of the body);
heart failure in chronic form;
cardialgia(pain in the left side of the chest), caused by;
bronchial asthma;
COPD;
alcohol withdrawal(as an addition to specific therapy);
stroke.

Additional indications for the use of drug injections:

hemorrhage into the vitreous cavity of the eye(hemophthalmos);
hemorrhage in the retina of the eye;
thrombosis and occlusion of the central retinal vein or its branches;
retinopathy of different nature of origin (for example, hemorrhagic or diabetic).

Mildronate is a drug that is characterized by the ability to expand the range of tolerance to physical (both dynamic and static) stress and intellectual function not only in ischemic injuries, but also in healthy people.

The drug is very useful for athletes due to its properties to improve nutrition heart muscle and other muscles of the body and reduce fatigue, while simultaneously increasing the effectiveness of sports training.

Contrary to popular belief, Mildronate is not used as a means to increase muscle mass. Its task in sports and in bodybuilding in particular is somewhat different: Mildronate for athletes is indicated as a prophylactic agent that prevents overwork (including heart muscle) and overtraining.

In addition, by promoting faster removal of breakdown products from cells and accelerating the restoration of cell energy resources, Mildronate improves metabolism at the cellular level and accelerates muscle recovery in athletes after physical activity. Moreover, the latter applies to both strength loads and physical loads on the speed and/or endurance of the body.

There is an opinion that the use of Mildronate in sports can provoke fatty liver hepatosis. However, it is unfounded.

Mildronate prevents fatty acids from penetrating into the cell and thus prevents the accumulation of fats in liver. In addition, by burning mainly sugars, the body consumes a larger amount of raw materials, which are fats, for each molecule produced adenosine triphosphate ( that is, for energy production).

Meldonium was not classified as a doping drug until January 1, 2016, which made it possible to use it absolutely legally in all sports.

However, after the introduction of a ban on the use of the drug by the World Anti-Doping Agency (WADA) at the beginning of 2016, a number of athletes, mainly from Russia and the former CIS countries, were caught using this drug. Mildronate also became the subject of a huge scandal when Maria Sharapova admitted using this doping on March 7, 2016.

Contraindications to the use of Mildronate (for all forms of the drug):

increased individual sensitivity to Meldonia or any of the auxiliary components of the drug;
intracranial hypertension, including those caused by intracranial tumors and disorders of venous outflow.

Side effects caused by taking Mildronate occur quite often. Typically they are expressed as:

allergic reactions(redness, skin rashes, itching and swelling);
dyspeptic symptoms, manifested by belching, attacks of nausea, vomiting, heartburn, a feeling of fullness in the stomach even after a small portion of food;
tachycardia;
increased arousal;
decline in performance blood pressure.

You can often come across the questions “Can Mildronate be administered intramuscularly?” or “Can the drug be injected intramuscularly?”

The instructions for medical use indicate that the drug in injection form is intended for intravenous administration, and capsules and tablets are intended for oral administration (per os).

Dosage forms for oral administration should be taken whole, without chewing, crushing or pouring out the contents of the capsules.

Mildronate for intravenous administration is produced in finished form. Mildronate should be administered intravenously separately from other drugs; dilution with an aqueous solution of sodium chloride is not required (however, in some cases it is allowed).

When injected into a muscle, the injection solution has an irritating effect and can cause local pain and allergic reactions of a local nature. For this reason, the drug Mildronate is usually injected into a vein.

Indications for the use of Mildronate injections: unstable (progressive) angina pectoris, myocardial infarction, vascular pathologies of the fundus and cerebral circulatory disorders.

Patients with coronary syndrome the drug is injected into a vein in a stream at a dose of 500-1000 mg, once a day. After this, therapy is continued by taking tablets or capsules.

Patients with vascular pathologies of the fundus the medicine is administered retrobulbarly (behind the eyeball) or subconjunctivally (under the outer shell of the eyeball) 0.5 ml for 10 days.

For patients in the acute stage, the solution is administered into a vein once a day at a dose of 500 mg. The duration of the therapeutic course is 10 days. Further treatment is carried out using oral dosage forms.

Patients with cerebral circulatory disorders in the chronic form, intramuscular administration of Mildronate is indicated one to three times a day at a dose of 500 mg (optimally before lunch). The duration of the therapeutic course is from 2 to 3 weeks.

Patients with diseases of the cardiovascular system Mildronate tablets and capsules are indicated in combination with specific therapy. The drug is taken at 500-1000 mg per day. The entire dose can be taken either at once or divided into two doses.

As a rule, the course of treatment lasts from 4 to 6 weeks.

At cardialgia, conditioned dyshormonal myocardiopathy, Mildronate is taken once a day, one tablet of 500 mg or 2 tablets of 250 mg.

Patients with cerebral circulatory disorders after eliminating acute disorders, the use of the drug in a dose of 500-1000 mg per day is indicated. Take it in one dose or divided into two doses.

Patients with cerebrovascular disorders in chronic form, it is recommended to take 500 mg of Mildronate per day.

The duration of treatment varies from 4 to 6 weeks. At the discretion of the attending physician, the patient may be prescribed repeated courses of treatment (usually two or three times a year).

Patients with pathologies of peripheral arteries are prescribed to take the drug twice a day, 500 mg. The recommended dose for increased intellectual and physical stress on the body (including athletes) is 1000 mg, which should be divided into two doses.

The duration of treatment is from 10 to 14 days. If necessary, the course is repeated after a two- or three-week interval.

In the period before training, athletes are recommended to take Mildronate twice a day at a dose of 500-1000 mg. The duration of treatment in the preparatory period is usually from two to three weeks, during the competition period its duration varies from 10 to 14 days.

At alcohol withdrawal Patients suffering from chronic alcoholism should take Mildronate 500 mg four times a day. The duration of the course is from 7 to 10 days.

The maximum permissible daily dose is considered to be 2000 mg.

No cases of overdose have been recorded. The drug Mildronate is characterized as low-toxic and does not provoke side effects that could threaten the patient's health.

It is allowed to combine Mildronate with antianginal, antiarrhythmic, anticoagulant, antiplatelet And diuretic medicines, cardiac glycosides, bronchodilators and other drugs.

Mildronate has the ability to potentiate the action Nitroglycerin, β-adrenergic blockers; nifedepine and other drugs that have coronary action; antihypertensive drugs, as well as agents whose action is aimed at peripheral vasodilation.

Due to the possible development of moderate tachycardia and decline in indicators blood pressure the above agents should be used in combination with Mildronate with caution.

Mildronate belongs to the category of prescription drugs.

Mildronate should be stored in a dry place. Keep away from children. The optimal temperature is not higher than 25°C.

48 months.

Due to the fact that the drug can provoke a stimulating effect, it is recommended to use it in the first half of the day.

There are no data regarding the ability of Mildronate to change the reaction rate and influence transport control.

The drug is prescribed with caution to people with liver and/or kidney pathologies.

Experience in treating patients with myocardial infarction and unstable angina pectoris shows that the active substance Mildronate is not a first-line drug for ACS.

Analogues of Mildronate: Vasopro, Vazonat, Metamax, Methonate, Trizipin, Mildracore, Mildrocard, Cardionate, Melfort, Idrinol, Riboxil, Meldonium.

The price of drug analogues starts from 170 Russian rubles.

Riboxin is a natural compound found also in the human body.

As a predecessor adenosine triphosphate, it helps improve energy balance heart muscle, improvement coronary circulation, reduces the severity of the consequences intraoperative ischemic kidney damage, stimulates production nucleotides and the activity of individual enzymes of the citrate cycle.

The product has a positive effect on metabolic processes in heart muscle, increases the strength of its contractions and stimulates its more complete relaxation in diastole, which in turn leads to an increase in stroke volume (stroke blood volume) indicators.

Mildronate has a similar effect, but is not itself involved in the synthesis of other substances. At the same time, the drug regulates the activity and enzyme biosynthesis, taking part in energy production, and thus normalizes metabolism.

The conclusion is this: Mildronate is a drug whose action is aimed at correcting metabolic processes, Riboxin It also takes part in biochemical reactions and is a means of metabolic action.

To obtain the expected effect from use Riboxin it should be administered in quantities that are comparable to its consumption in the body. And since Riboxin is used by the body in various reactions, it is required in very large quantities.

Mildronate, on the contrary, is not consumed in metabolic reactions; its effect lasts for a longer period of time, and the body requires much less of it than Riboxin.

Therefore, the use of Mildronate improves the use of the body Riboxin. Thus, the combined use of these drugs will potentiate each other's effects.

Cardionate and Mildronate are synonymous drugs. They are based on the same active ingredient, so both products have a similar mechanism of action.

Their only difference is that, unlike Mildronate Cardionate Available only in the form of capsules 250 mg and solution for injection 500 mg/5 ml.

Since today there is insufficient data on the safety of Mildronate in pediatric practice, the drug should not be used to treat children.

The active substance of Mildronate is excreted from the body within 12 hours, therefore, after this time, the risk of interaction of the drug with another active substance is extremely low or completely absent.

In general, drinking alcohol during treatment with Mildronate is not prohibited; however, if this drug is used to treat cardiovascular disease or when cerebral circulatory disorders However, the patient is still advised to stop drinking alcohol.

This is due to the fact that taking the drug in combination with alcohol can negate all the positive results that have been achieved in treating the disease.

Taking Mildronate with alcohol can provoke:

tachycardia;
pronounced allergic reactions;
sharp fluctuations in blood pressure;
dyspeptic symptoms.

The poor compatibility of Mildronate with alcohol is due to an increased risk of various types of complications and the likelihood of a relapse of the disease. For this reason, alcohol should be excluded for the entire period of treatment with the drug.

The safety of Mildronate for the treatment of pregnant women has not been proven. To exclude the possibility of its adverse effects on fetal development, the drug not prescribed during pregnancy.

It has not been established whether meldonium excreted into the milk of a nursing woman. Therefore, if treatment with Mildronate is indicated for the mother, she needs stop breastfeeding.

Mildronate (international nonproprietary name - meldonium) is a very interesting drug, synthesized in the 70s of the last century by scientists of the Academy of Sciences of Latvia, which has firmly established itself on Russian pharmacy counters. It has a whole range of pharmacological effects: antianginal (directed against angina attacks), cardioprotective, antihypoxic (increasing resistance to oxygen starvation) and angioprotective (beneficially affecting the vascular wall and microcirculation). To be fair, it should be noted that mildronate has not yet earned recognition either in Europe or in the USA. However, its effectiveness was confirmed according to all the rules of evidence-based medicine in two double-blind randomized clinical trials conducted in Riga and Tomsk. And it is unlikely that mildronate would have managed to gain such popularity among domestic specialists, patients and even athletes if it had been a useless “dummy”.

Against the background of increased load, the drug balances the processes of oxygen delivery to cells and its consumption at the destination, prevents the accumulation of toxic breakdown products in cells, protecting them from damage, and has a tonic effect. Thanks to mildronate, the body is endowed with the ability to withstand increased stress and quickly restore its energy reserves. In this regard, mildronate is used in the treatment of various cardiovascular pathologies, cerebral circulatory disorders, and increasing mental and physical performance.

The vasodilating properties of mildronate are due to its ability to reduce the concentration of carnitine while increasing the synthesis of gamma-butyrobetaine. In acute ischemia of the heart muscle, the drug slows down the necrotic degeneration of myocytes and accelerates the rehabilitation process. In case of heart failure, mildronate helps the myocardium to contract better and withstand physical activity. In acute and chronic cerebral ischemia, the drug improves cerebral circulation and optimizes microcirculation in favor of the tissue area most affected by ischemia. In ophthalmology, mildronate is used in cases of vascular and dystrophic pathology of the fundus. Due to its ability to eliminate functional disorders of the central nervous system in persons suffering from alcoholism, the drug is effective in treating withdrawal symptoms.

The Latvian pharmaceutical industry has mastered the production of three dosage forms of mildronate: capsules, solution for intravenous and parabulbar (in the lower eyelid) administration, and syrup. Specific dosages of the drug depending on the disease and age of the patient can be found in the package inserts, although, given the prescription order for dispensing mildronate (including syrup), this is not necessary, because The last (and even the first) word in any case remains with the doctor.

Pharmacology

A drug that improves metabolism and energy supply to tissues. Meldonium dihydrate is a synthetic analogue of gamma-butyrobetaine, a substance that is found in every cell of the human body.

The mechanism of action determines the variety of its pharmacological effects: increased performance, reduced symptoms of mental and physical stress, activation of tissue and humoral immunity, cardioprotective effect.

Inhibits gamma-butyrobetaine hydrooxinase, reduces the synthesis of carnitine and the transport of long-chain fatty acids through cell membranes, prevents the accumulation in cells of activated forms of unoxidized fatty acids - derivatives of acylcarnitine and acyl coenzyme A. Under ischemic conditions, meldonium restores the balance between the processes of oxygen delivery and its consumption in cells, prevents disruption of ATP transport; At the same time, it activates glycolysis, which occurs without additional oxygen consumption. As a result of a decrease in carnitine concentration, gamma-butyrobetaine, which has vasodilating properties, is intensively synthesized.

It has a cardioprotective effect and normalizes myocardial metabolism. In case of acute ischemic damage to the myocardium, meldonium slows down the formation of the necrotic zone and shortens the rehabilitation period. In heart failure, the drug increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks.

In acute and chronic ischemic disorders of cerebral circulation, it improves blood circulation in the ischemic area and promotes the redistribution of blood in favor of the ischemic area.

Effective for vascular and dystrophic pathology of the fundus.

It has a tonic effect on the central nervous system, eliminates functional disorders of the somatic and autonomic nervous system in patients with chronic alcoholism with abstinence syndrome.

Pharmacokinetics

Suction

After oral administration, meldonium dihydrate is rapidly absorbed from the gastrointestinal tract. Bioavailability is 78%. Cmax in blood plasma is achieved 1-2 hours after oral administration.

Metabolism and excretion

Metabolized mainly in the liver with the formation of two main metabolites, which are excreted by the kidneys. T1/2 when taken orally is 3-6 hours and depends on the dose.

Release form

Hard gelatin capsules, size No. 1, white; the contents of the capsules are white crystalline powder with a slight odor, hygroscopic.

Excipients: potato starch - 13.6 mg, colloidal silicon dioxide - 5.4 mg, calcium stearate - 2.7 mg.

Composition of the capsule shell: titanium dioxide (E171) - 2%, gelatin - up to 100%.

10 pieces. - contour cell packaging (4) - cardboard packs.

Dosage

Due to the possibility of developing an stimulating effect, the drug is recommended to be used in the first half of the day and no later than 17.00 (if taken several times a day).

For ischemic heart disease (angina pectoris, myocardial infarction), chronic heart failure, as part of complex therapy, the drug is prescribed orally at a dose of 0.5-1 g/day, frequency of use 1-2 times/day. The course of treatment is 4-6 weeks.

For dishormonal cardiomyopathy, Mildronate ® as part of complex therapy is prescribed orally at a dose of 500 mg/day. The course of treatment is 12 days.

In case of subacute cerebrovascular accidents (stroke and cerebrovascular insufficiency), after completing the course of injection therapy with Mildronate ®, continue to be taken orally as part of complex therapy at 0.5-1 g/day, using the entire dose once or dividing it into 2 doses. The course of treatment is 4-6 weeks.

For chronic cerebrovascular accidents, the drug is taken orally as part of complex therapy at a dose of 0.5 g/day. The general course of therapy is 4-6 weeks. Repeated courses are possible after consultation with a doctor (usually 2-3 times a year).

In case of reduced performance, mental and physical stress (including in athletes), 500 mg is prescribed orally 2 times a day. The course of treatment is 10-14 days. If necessary, therapy is repeated after 2-3 weeks.

For withdrawal syndrome in chronic alcoholism (in combination with specific therapy for alcoholism), the drug is prescribed orally at 500 mg 4 times a day. The course of treatment is 7-10 days.

Overdose

Symptoms: decreased blood pressure, accompanied by headache, tachycardia, dizziness and general weakness.

Treatment: symptomatic therapy.

Interaction

Mildronate ® enhances the effect of coronary dilatants, some antihypertensive drugs, and cardiac glycosides.

Mildronate ® can be combined with prolonged forms of nitrates, other antianginal drugs, anticoagulants and antiplatelet agents, antiarrhythmic drugs, diuretics and bronchodilators.

Due to the possible development of tachycardia and arterial hypotension, caution should be exercised when combined with nitroglycerin (for sublingual use) and antihypertensive drugs (especially alpha-blockers and short-acting forms of nifedipine).

Side effects

Rarely - allergic reactions (redness and itching of the skin, skin rash, urticaria, angioedema), as well as dyspeptic symptoms, tachycardia, decreased or increased blood pressure, increased excitability.

Very rarely - eosinophilia, general weakness.

Indications

as part of complex therapy for coronary artery disease (angina pectoris, myocardial infarction), chronic heart failure, dyshormonal cardiomyopathy;
as part of complex therapy for subacute and chronic cerebrovascular accidents (stroke and cerebrovascular insufficiency);
reduced performance;
mental and physical stress (including among athletes);
withdrawal syndrome in chronic alcoholism (in combination with specific therapy for alcoholism).

Contraindications

increased intracranial pressure (including in case of impaired venous outflow, intracranial tumors);
age under 18 years (efficacy and safety have not been established);
pregnancy;
lactation period (breastfeeding);
hypersensitivity to the active substance and other components of the drug.

The drug should be used with caution in case of liver and/or kidney diseases.

Features of application

Use during pregnancy and breastfeeding

The safety of the drug during pregnancy has not been established. To avoid possible adverse effects on the fetus, Mildronate ® should not be prescribed during pregnancy.

It is not known whether meldonium dihydrate is excreted in breast milk. If it is necessary to use the drug Mildronate ® during lactation, breastfeeding should be discontinued.

Use for liver dysfunction

Use with caution in case of liver diseases.

Use for renal impairment

Use with caution in case of kidney disease.

Use in children

Contraindicated for use in children and adolescents under 18 years of age (efficacy and safety have not been established).

special instructions

Patients with chronic liver and kidney diseases should be careful with long-term use of the drug.

Use in pediatrics

There is insufficient data on the use of Mildronate ® in children and adolescents under 18 years of age.

Impact on the ability to drive vehicles and operate machinery

There is no data on the adverse effects of the drug Mildronate ® on the ability to drive vehicles and operate machinery.

The description is valid on 09.03.2016

Latin name: Mildronate
ATX code: S01EB
Active substance: Meldonium
Manufacturer: JSC “Grindeks”, Latvia

Compound

To make the gelatin shell, Gelatinum (gelatin) and Titanium dioxyde (titanium dioxide) are used.

One milliliter of injection solution Mildronate contains 100 mg Meldonia and water for injection as an auxiliary component.

Release form

The drug Mildronate is produced by the manufacturer in the form:

clear colorless solution for injection;
hard gelatin capsules No. 1 and No. 2, filled with hygroscopic white crystalline powder. The powder contained in the capsules has a weak characteristic odor and a sweetish taste (the capsule itself has a neutral taste);
tablets Mildronate Gx 500 mg (tablet taste slightly sour).

The solution is sold in 5 ml ampoules (500 mg/5 ml). One cardboard package contains: 2 blister packs with 5 ampoules of Mildronate in each and instructions for use of the drug.

Capsules are packaged in blisters of 10 pieces each. One cardboard box contains 4 blisters and instructions for use of the drug.

pharmachologic effect

According to Wikipedia, meldonium characterized by the ability to improve the energy supply of cells and is used as:

cardioprotective ;
antihypoxic ;
angioprotective ;
antianginal means.

In patients suffering from heart failure , increases the strength of contractions heart muscle , reduces frequency heart attacks (attacks), and also increases the body’s tolerance to physical activity.

Toning CNS , meldonium effectively eliminates functional impairments somatic and autonomic (autonomic) parts of the nervous system , including violations that accompany withdrawal syndrome in patients suffering from chronic alcoholism.

In addition, the substance has a beneficial effect on the condition dystrophically altered retinal vessels , which allows it to be used for treatment vascular and dystrophic pathologies of the fundus .

Pharmacodynamics and pharmacokinetics

The action of the active substance of the drug is aimed at inhibiting the enzymatic activity of γ-butyrobetaine hydroxylase, which is the last enzyme in the chain reaction of synthesis.

Meldonium helps reduce the concentration of free , prevents transport through cell membranes long chain fatty acids, prevents the accumulation in cells of activated forms of unoxidized fatty acids, which are derivatives acylcarnitine And acyl coenzyme .

The result of a decrease in concentration carnitine is the enhanced synthesis of the vasodilator γ-butyrobetaine.

After taking the Mildronate tablet per os, it contains meldonium quickly absorbed in the digestive tract. The drug is characterized by a fairly high bioavailability index. The latter is approximately 78%.

Concentration Meldonia reaches its maximum values an hour or two after administration. In organism meldonium metabolized to non-toxic products - glucose, succinate, 3-hydroxypropionic acid.

It has not been established whether meldonium excreted into the milk of a nursing woman. Therefore, if treatment with Mildronate is indicated for the mother, she needs stop .

Reviews of Mildronate

Reviews of Mildronate on forums largely positive. The unique mechanism of action of this drug allows it to be widely used to eliminate problems with cardiovascular system , and also as a means of increasing performance in healthy people who are subject to frequent physical and intellectual overload.

Both patients in cardiology departments, doctors, and athletes note the fact that Mildronate provokes a tonic effect. Its use significantly improves memory function, accelerates thought processes, increases dexterity, endurance and the degree of body resistance to adverse factors.

Reviews from cardiologists confirm the data of numerous studies that have shown that the use of Mildronate in capsules and in the form of a solution for injections can reduce the incidence of recurrent episodes by more than nine times myocardial infarction .

Reviews from patients about Mildronate allow us to conclude that the drug is simply necessary for people whose activities are associated with increased stress on the body, as well as during the recovery period after prolonged alcohol abuse, with pain and burning in the heart area, VSD and other pathologies of cardio-vascular system .

Average rating for this product 4,8-5 out of 5 points.

However, sometimes you come across negative reviews about Mildronate. It is important to remember that, like any other drug, Mildronate gives a good result only if its dose and concomitant treatment (if necessary) are selected correctly.

Mildronate price

Price of the drug on the Ukrainian market

The average price of Mildronate 250 mg tablets is 214.1 UAH. The price of Mildronate ampoules of 5 ml is 383.95 UAH. Capsules 500 mg cost 323-325 UAH per package. Mildronate Gx is sold for an average of 233-240 UAH.

Studies that have been aimed at studying many chronic diseases have shown that the metabolism is most often subject to severe shock.

Regardless of the type and duration of the disease, the body’s tissues suffer from a lack of oxygen, since the metabolism is disrupted and does not perform its functions.

Mildronate for blood pressure is a drug designed specifically to affect the functioning of cells during an exacerbation of the disease.

Diseases of any kind expose the body to additional stress. The drug blocks harmful enzymes, saturating cells with oxygen and increasing their tone. Thanks to this action, toxins do not linger in the tissues and are quickly removed without destroying natural processes.

Mildronate helps with neuroses and in many cases when it is necessary. This medicine is often prescribed for vision and retinal diseases.

If significant disturbances in the functioning of blood vessels occur in the eye, then blood does not flow into the organ.

This can lead to dystrophy and vision loss.

The medication has a positive effect on the condition of all blood vessels in the body, therefore it is most often used for Mildronate hypertension, which continues to spread and affect even young and completely healthy people.

The drug is used not only in a narrow direction for treating and stabilizing blood pressure. It is prescribed in many cases regarding other chronic diseases. It is part of complex treatment, so its scope of action is quite large.

The medicine is capable of:

saturate all cells and muscles with energy, stabilizing blood pressure. The vessels become more elastic and stronger, and the veins are no longer at risk of expansion or thrombus formation, which is very dangerous not only for health, but also for life;
influence the tone of the whole body, restore vitality. Also significantly improve metabolism and direct it in a healthy direction;
cure heart disease, as well as strengthen the vascular system of the whole body;
influence the entire body at the cellular level. Thanks to this action, you can quickly recover even from chronic ailments, which are always very difficult to get rid of.

It is important to understand the cause of high blood pressure, since treating symptoms does not always give the desired effect. The disease returns with renewed vigor, sweeping away the previously built treatment system.

Often hypertension is caused by severe overwork, negative external factors that lead to stress, depression, and fatigue.

This is related to work, study, and sometimes relationships. It is not always possible to prevent and prevent the disease, since with chronic fatigue perception worsens, and the body no longer reacts to stimuli as well as before.

Mildronate acts on the problem itself, on the cause of hypertension - this is its advantage. Pathology is completely eradicated. It’s not for nothing that this drug is called a universal remedy that saves “from many troubles.”

Effect on the body

If we take into account the fact that the medication acts at the microscopic level, regulating the proper functioning and vital activity of cells, then we can distinguish several options for its effect on the body:

therapeutic effect. Produces dramatic changes in the protective functions of cells. Now the heart is under the influence of a drug that protects it from stress and creates a kind of additional immunity to negative circumstances. The cells and tissues of this important organ are strengthened and become more resistant to external stress;
reducing the risk of developing angina pectoris. Influence on the emotional state, strengthening the nervous system and preparing it for various types of stress;
body toning. All small particles of the body come into combat readiness. The incentive to live increases, the strength to work appears. The vessels are saturated with blood and oxygen, as a result of which the pressure is completely normalized, and the person feels quite well.;
oxygen saturation of all muscles, tissues and cells. It is precisely because of the lack of this vital substance that various ailments and unjustified weaknesses can arise;
the walls of blood vessels become denser and stronger, able to withstand strong pressure. Thanks to this, they do not burst, and the pressure soon normalizes;
a kind of protection against microorganisms, capable of disrupting the integrity of tissues and causing a relapse of the viral disease.

Compound

In addition to the main substance meldonium, the medicine contains many natural components, both plant and chemical. This is the potato starch familiar to everyone, which holds the composition together and creates a dense mass. This also includes gelatin.

Mildronate capsules

Auxiliary chemicals: calcium stearate and silicon dioxide. Created on the basis of distilled water, if we talk about injections. Mildronate syrup also has a water base and dyes, flavorings and glycerin.

You can often hear the following question: “Mildronate or Meldonium – which helps better with high blood pressure?” Mildronate is Meldonium, so the question can be considered closed.

Mildronate tablets or injections – which is better to take? The choice of dosage form is made individually depending on the characteristics of the human body and his wishes. For example, if a person has difficulty swallowing tablets, it is better to take it in the form of an injection solution or syrup.

Indications for use

If a person is constantly exposed to intense physical activity, he needs to recover from time to time.

But sometimes there is not enough time for this, so the cells are in a deplorable state, “demanding” increased attention.

This is felt by the entire body, since in the tissues the lack of oxygen makes itself felt clearly.

The drug saturates the blood with the necessary substance and distributes it throughout the body. At the same time, it promotes high-quality cleansing of cells and the removal of toxins from them so that they do not spread throughout the body and poison the brain.

High blood pressure is treated very effectively with the drug. In this case, the medicine is prescribed after a heart attack in the form of a supportive and restorative agent. It helps to stop the negative destructive process in tissues and prevents necrosis.

With proper treatment, rehabilitation is several times faster and more effective. Heart failure can be cured by toning the heart muscle. The drug prevents the occurrence of angina pectoris, strengthening the heart, and also allows you to endure serious loads that the body could not withstand before.

In case of disturbances in processes in the brain, the drug saturates important cells with blood, allowing the restoration of healthy blood circulation.

The action occurs due to the correct distribution of pressure in all areas of the brain, where there was a catastrophic lack of oxygen and other important, useful substances.

Mildronate helps in case of alcohol intoxication, strengthening the nervous system. A person comes to his senses much faster. His reaction becomes healthier. Tremor disappears, memory is normalized and the ability to concentrate for a long time is restored.

The medicine quickly restores energy, replenishing tissues and cells with oxygen. This allows you to feel cheerful, lead an active life and for a long time forget about weakness and high blood pressure, which cannot be rested. The ability to work quickly and make quick decisions is significantly improved. The drug relieves stress from physical and emotional stress.

Mildronate is prescribed for diseases such as:

high blood pressure;
heart attack or threat thereof;
angina attacks that are constant or occur occasionally;
problems with blood circulation in the brain, oxygen deficiency, risk of stroke, post-stroke condition;
vision problems, retinal disorders, weakening of blood vessels and nerve endings;
alcoholism at any stage. Chronic drinking is treated in combination with regular use of the drug;
the rehabilitation period after simple and complex operations, when the body requires complete recovery;
is prescribed to athletes in case of excessive loads, so that tissues can quickly get used to the new regime, and damaged cells can quickly recover.

How many times a year can Mildronate be taken? The course of treatment is prescribed individually; as a rule, it must be completed 2-3 times a year. In complex treatment, the drug is prescribed even to asthmatics, as well as for prolonged bronchitis. The medicine is safe for adolescents who experience temporary disturbances in the stability of blood pressure, heart function and blood vessels.

Instructions for use of the drug Meldronate: dosage and general recommendations

How to drink Mildronate in tablets and syrup form? Tablets or syrup should be taken half an hour before meals or before the meal itself.

The drug has a tonic effect on the nervous system and causes excitatory reactions. Therefore, it is preferable to apply in the morning or afternoon.

If the medicine is prescribed by a doctor to be taken two or three times a day, it is better to limit it to daytime and not use the medicine after five in the evening so that it does not affect the quality of sleep.

The course of treatment is usually long, lasting a month or 40 days, depending on the complexity and type of disease. In order for the medication to “work” more intensively, it can be combined with tablets containing nitrates. This will ensure its duration of action.

How often can you take Mildronate for hypertension? For high blood pressure, you need to take the medicine up to 3 times a day. You can immediately drink the required dose, if this is permissible in an individual case.

If asthenic syndrome is observed with hypertension, it is better not to take pills, but to purchase syrup, which can be consumed 4 times a day, 5 ml. This treatment lasts 14 days for final healing of the disease.

Side effects when given an injection

Is it possible to take Mildronate continuously? With prolonged use of the drug in the form of syrup or tablets, no negative effects were observed.

But with injections, temporary weakness may occur and blood pressure may drop significantly.

Therefore, it is better to beware of taking Mildronate injection solution at low blood pressure. You can often experience dizziness and disturbances in the functioning of the heart - a strong beating. If an overdose occurs, you need to be treated based on the symptoms that appear.

Video on the topic

Instructions for use of Mildronate in capsules:

During heavy fighting in Afghanistan, Soviet scientists began to think about increasing the performance and endurance of soldiers, as well as reducing their mortality. Severe stress, hypoxia, and excessive physical activity undermined the health of employees.

Then scientists thought about a substance that could support the body under such conditions. They analyzed the work of German scientists in the 20s and discovered a chemical compound released by the body under stress.

In the early 80s, Latvian pharmacists invented a drug based on meldonium, a substance that normalizes metabolic processes in body cells exposed to hypoxia or ischemia. Then Mildronate, a medicine that mobilizes vital energy in the body, was released into mass production. This drug began to be widely used by athletes and the military because of its wonderful properties. Next, the fact was discovered that Mildronate is able to help people with heart disease.

Today this drug is the best-selling drug in Russia and the CIS countries; people like to use it in treatment and as an assistant in restoring strength.

The drug is available in the form of tablets, capsules or ampoules with liquid for injection:

Injections in ampoules contain a clear, colorless liquid with a volume of 5 ml (500 mg/5 ml). They are packaged in packs of 10 ampoules, each pack contains attached instructions for use. Mildronate ampoules consist of 100 mg of Meldonium and water for injection.
Capsules made from gelatin contain 250 or 500 mg of Meldonium and excipients. The capsule powder has a characteristic mild aftertaste. The capsules are packaged in blisters, each pack contains 4 blisters of 10 capsules each, and instructions for use of the medicine.
Mildronate tablets have a slightly sour taste. Each tablet contains 500 mg of Meldonium and excipients. The box contains 40 tablets and instructions for use.

How does Mildronate affect the body?

The active component of the drug, Meldonium is a synthetic substance similar to human γ-butyrobetaine (a substance similar to B vitamins). This substance can improve metabolism and enhance the process of energy exchange in the cells of the body, which characterizes the healing properties of the medicine.

Meldonium is able to activate tissue and anti-infective immunity. From the cardiovascular system, Mildronate helps cardiac activity, giving strength to contractions, as well as to endure heavy physical activity.

The medicine can help with coronary heart disease by helping to redistribute blood in damaged areas. Injections successfully help with chronic heart failure. Mildronate increases myocardial contractility, increases exercise tolerance, and reduces the frequency of angina attacks.

Mildronate allows you to quickly deliver oxygen to cells during physical stress, then removes the products of cellular metabolism with toxins from the body. At the same time, Mildronate is able to protect cells from damage, replenish energy reserves and maintain a high metabolic rate in the body.

The drug can help with chronic alcoholism by stimulating the nervous system. Meldonium may also be useful in treating seizures and alcohol intoxication.

In tandem with other drugs such as metformin, the drug has been shown to have beneficial effects on neurological disorders and diabetes.

Meldonium also has indications for mental stress; it can improve learning and memory.

Some studies have shown the drug's ability to affect sperm motility and increase the concentration of testosterone in the blood of men, which has a beneficial effect on sexual performance and the conception of a healthy child.

Under conditions of high load, Mildronate restores the balance between the supply and need for oxygen in cells, eliminates the accumulation of toxic metabolic products in cells, protecting them from damage, and also has a tonic effect. As a result of its use, the body acquires the ability to resist stress and quickly restore energy reserves.

Treats acute and chronic ischemic disorders of cerebral circulation, improves blood circulation in the ischemic area, promotes blood redistribution in favor of the ischemic area.

The indication for use of the drug is vascular pathology and retinal dystrophy.

How is the drug processed by the body?

When consuming Mildronate tablets or capsules, the active substances are quickly absorbed into the digestive tract. The medicine is processed by the body by 78%, the rest is excreted from the body through the kidneys.

1-2 hours after taking the tablet, the concentration of the drug in the blood reaches its maximum. After this, Mildronate decomposes into non-toxic products: glucose, succinate and hydroxypropionic acid. The kidneys remove these substances from the body within three to six hours.

In the form of an injection, the drug is processed by the body 100%. Immediately upon administration of the drug, its concentration increases as much as possible in the blood. Therefore, intravenous injections are used for the fastest possible effect on the affected areas.

In what form is it better to take the drug?

There are indications for the use of the drug both in tablets (or capsules) and in injections intravenously and intramuscularly for the following diseases:

Cardiac ischemia.
Peripheral arterial diseases.
Chronic form of heart failure.
Encephalopathy.
Cardialgia with dyshormonal myocardiopathy.
Bronchial asthma.
Alcohol withdrawal.
Brain stroke.
Physical and mental overload.
Decreased performance and
The period of recovery of the body after surgery.

Mildronate injections have additional indications:

Damage to the vitreous body or retina of the eye, and as a result - hemorrhage.
Thrombosis of the central vein of the eye or its branches.
Retinopathy (damage to the blood vessels of the eye, for example, as a complication of diabetes).

Capsules or tablets of the drug should be taken without chewing, crushing or breaking the membranes, orally.

Injections are administered intravenously, since an intramuscular injection provokes severe pain and can provoke local allergies. But some indications take into account that intramuscular injection of the drug is necessary. For example, with chronic cerebral circulatory disorders.

For diseases of the blood vessels of the eye, the drug is administered by injection behind the eyeball or under the outer shell of the eye.

Use of the drug during sports

Mildronate is widely known among professional athletes for its properties in helping the body recover after intense training.

It is immediately necessary to understand that the drug is not a dope. It is allowed when exercising both power and dynamic loads.

Meldonium helps oxygenate cells in need and removes breakdown products. In addition, it energetically nourishes cells. These actions contribute to faster recovery after heavy physical exercise, which means better training results. When an athlete recovers faster, he starts the next workout earlier, and then his productivity increases.

Indications for the use of the drug for athletes exist when he has a period of intense and frequent training, and he does not have time to recover between them. The instructions for use are as follows: capsules or tablets should contain up to 1 gram of the substance per day in a total dosage; take them 30 minutes before training.

Intravenous injections are more effective; the daily dose for an athlete is 5-10 ml. The course of treatment should last no longer than six weeks. The drug is not addictive.

It should be remembered that taking an injection of medication or orally capsules or tablets will not replace the athlete with a nutritious diet rich in carbohydrates and proteins. If you are on a very limited diet, there is no point in taking Mildronate, since it will not affect the exhausted body.

The ability of the drug to prevent fatty acids from entering the body's cells helps to achieve a weight loss effect during intense exercise.

When is Mildronate contraindicated?

The instructions for use of the medicine clearly indicate a warning about allergic reactions to the components of the drug. Its use should be interrupted if you notice itching or redness on your skin, shortness of breath or swelling.
For symptoms of indigestion or poor stomach function - heartburn, bloating, vomiting, belching, and the like.
Increased excitability.
Tachycardia.
Low blood pressure.
Pregnancy and breastfeeding period.
For pathologies of the kidneys and liver, this substance is prescribed in extreme cases.
There is insufficient data on the use of Mildronate in children.

Due to the fact that the drug is considered non-toxic, in case of an overdose it will not cause excessively dangerous side effects.

The instructions remind you that you cannot combine the use of medication and alcohol, especially if it is used to treat cardiovascular diseases.

The drug is sold in pharmacies only with a prescription from the attending physician.

It is better to take it only in the first half of the day, as it can cause a stimulating effect on the nervous system. There is no information on the effect on driving.