Polyoxidonium: instructions for use of the drug, composition, action. Suppositories, injections, tablets Polyoxidonium: instructions for use for children and adults Polyoxidonium 3 and 6 milligrams

Every person throughout his life strives to strengthen his immune system and protect himself from various diseases. Every year the relevance of such aspirations is growing, which is associated with climate deterioration, environmental pollution, etc. Many will say that today there are no problems with strengthening the immune system, since pharmacies are overflowing with various types of immunomodulators that are produced not only abroad. One of the many modern domestically produced immunomodulators is a product called Polyoxidonium. This is exactly what will be discussed in this material. Let's find out in more detail why the drug is prescribed, how it works, where it is used, and why it is popular?

Features of Polyoxidonium

Polyoxidonium is a little-known drug, but doctors very often prescribe it to children to strengthen the immune system. Polyoxidonium is also prescribed for adults, if necessary. Most doctors prefer this drug, justifying this by the fact that the best immunomodulator simply does not exist.

Polyoxidonium is the best drug for its intended purpose, as it has a complex effect. With its help, it is possible not only to create a barrier to the penetration of viruses and bacteria, but also to prevent the spread of diseases and various complications. When using Polyoxidonium, it has been repeatedly observed that the patient feels better. With its help, the human body is able to resist various viruses, bacteria, fungi and other pathogenic microorganisms.

Polyoxidonium is actively involved in the procedure for eliminating signs of the disease, which is due to its high immunomodulatory properties. In addition to immunomodulatory, this drug also has antioxidant, anti-inflammatory, detoxifying and anti-inflammatory properties. The drug in question is based on a substance called bromide azoximer.

The fundamental advantages of Polyoxidation include the following factors:

1. High speed effect. The product has a positive effect within 1-2 hours after taking it. This speed effect is achieved through the special and unique structure of the drug. Polyoxidonium contains active components that absorb pathogenic microorganisms and harmful particles, and then remove them from the body.
2. Versatility. The drug has an individual immunomodulatory effect, so it is prescribed to patients who have problems with the immune system.
3. Safety. The medicine contains exclusively components and substances of natural origin that do not pose a threat to human life. It should be noted that the drug contains a whole complex of useful components, but, at the same time, it has anti-allergenic properties. The drug has no side effects, which makes it even safer.
4. Wide selection of dosage forms. The drug is available in the following forms: tablets, injections, rectal suppositories. A wide selection of release forms allows you to choose the most optimal treatment option or strengthen the immune system.

The effectiveness of the drug is confirmed not only scientifically, but also by reviews of patients who used it to strengthen the immune system and treat various diseases. This drug is not only approved for use, but it is also included in the list of essential medications.

How does this drug work?

The constituent substances of the drug come into contact with the membranes of all human immune cells. Through this interaction, the activity of monocytes, microphages, and neutrophils is restored. After awakening, these immune cells begin the active process of capturing foreign microorganisms that are present in the body. Through this active awakening, there is an increase in the functioning of the immune system.

A person notices a decrease in pain, symptoms of the disease, as well as a decrease in the degree of tissue damage. Some time after the first dose of the drug Polyoxidonium, complete restoration of immunity is observed, which means that the person will soon recover and get better.

It is important to know! It has been proven that Polyoxidonium in any form of release is not capable of causing complications, which makes it more effective and safe.

Another advantage of the drug is the fact that after entering the body it independently determines immunity indicators. If the immune system does not need additional strengthening, then the drug has no effect, but in the opposite case it helps to increase the level of protection. Polyoxidonium regulates immunity indicators and brings them to a certain level. The drug is not only effective for viral, bacterial and fungal diseases, but also allows you to speed up wound healing even during the rehabilitation period after surgery.

The healing properties of Polyoxidonium are characterized by the following capabilities:

1. The medicine allows you to quickly and effectively eliminate pain and intoxication syndromes.
2. Reduces the degree of tissue damage.
3. Allows you to prevent the development of various types of complications.
4. Reduce the duration of treatment several times.
5. Strengthen the body's defenses against the effects of various negative factors.
6. Increase the duration of the anti-inflammatory effect.
7. Reduce the toxicity of antibiotics, glucocorticosteroids and cytostatics if taken simultaneously with Polyoxidonium.
8. Increase the performance of human organs and systems.
9. Improve your well-being and lift your mood.

Polyoxidonium is effective not only for weakened immunity, but also for an organism that is sufficiently protected. Already after taking the first dose of the drug, an active process of confrontation with hostile microorganisms is launched.

It is important to know! Polyoxidonium is the first immunomodulator that has detoxifying properties.

This means that the drug is based on a large number of links through which the adsorption of toxic substances is carried out, as well as their removal from the body. This advantage is very useful if a person has acute infectious diseases in which it is necessary to revive the person. In acute infectious diseases, symptoms such as weakness, muscle aches, headaches, and cough appear. After using Polyoxidonium injections, these symptoms disappear on the first day.

Features of the use of Polyoxidonium

Immunomodulators are substances that increase and strengthen immunity. For a speedy recovery, it is necessary to take immunomodulators. The most effective of the existing drug options is Polyoxidonium. This drug allows you to quickly achieve the desired result, as well as consolidate it for a long time, provided that the medication is taken correctly.

The drug is indicated for use in patients who have signs and symptoms of a weakened protective function of the body. The drug is available in various forms, which have specific indications for use. Let's consider when it is better to use tablets, and in which cases to give preference to injections for injections.

1. Pills. This form of release is the most popular and in demand, as it is due to the advantage of ease of use. Tablets are used for the development of diseases of the respiratory system, ear, nose and throat, as well as for sinusitis, bronchitis, otitis, ARVI and even herpetic rash.
2. Candles. This form of drug release has found its use in the development of diseases such as tuberculosis, arthritis, dermatitis of unknown origin, colpitis, pyelonephritis, cystitis and other diseases of internal organs and systems.
3. Injections for injections. Polyoxidonium in the form of injections is used primarily for the complex treatment of various types of chronic diseases, inflammatory processes, as well as other types of diseases. Instructions for using Polyoxidonium in the form of injections state that the drug is effective for almost any disease, complications and pathologies. It can be used even if you have the problem of obesity, which is not a cosmetic, but a physical pathology. Injections for injections are used when it is necessary to treat acute and chronic ailments of various systems and organs.
4. Drop solution. It has similar indications for use as tablets.

Polyoxidonium is effective in all respects. Even if a person does not have any diseases, the drug can be taken as prescribed by a doctor as a prophylactic against inflammation and complications. The medicine helps to get rid of psychophysical stress, acclimatize to various changes in weather conditions and changes in terrain, and also restore intestinal microflora when using antibiotic drugs.

Presence of contraindications

Like any medicine, the drug called Polyoxidonium has contraindications, but the good news is the fact that their number is minimal. The main and only contraindications to the use of Polyoxidonium are:

• period of bearing a child;
• breastfeeding period.

These are two main contraindications, according to which the manufacturer strictly prohibits taking the immunomodulator. But in addition to these two factors, there are a few more that are of considerable importance:

1. If the patient has an individual intolerance to the drug. This happens extremely rarely, but an allergy to the drug cannot be ruled out.
2. It is not recommended to use the product in the form of suppositories and injections for children under 6 months. Tablets can be taken no earlier than 12 years of age.
3. If you have kidney problems, you should avoid taking the drug, as this may cause complications.

It is worth emphasizing that if a doctor prescribes a drug knowing about the patient’s kidney problems, then it can only be used under medical supervision. The drug does not cause side effects. The manufacturer characterizes this product as the most effective and safe immunomodulator. The drug does not have a negative effect on the circulatory, cardiovascular, digestive, nervous and other human systems. During its use, only positive changes are observed.

Polyoxidonium for adults: rules of use

The immunomodulator can be used not only for children, but also for adults. But how should you take the drug correctly? This needs to be looked into in more detail. First of all, you need to know that the drug should be used only as prescribed by a doctor. Even if the patient feels a loss of strength, energy and deterioration in well-being, then initially it is necessary to visit a therapist who, if necessary, will prescribe Polyoxidonium.

Pills. The tablets should be taken by swallowing them, followed by plenty of water. It is prohibited to take tablets with tea, coffee, or soda, as this will reduce the effectiveness of the product. You can also place the tablets under the tongue and dissolve. The tablets are taken exclusively before meals, 20-30 minutes before meals.

Depending on the diseases that need to be cured with Polyoxidonium, the dosage of tablets varies. For inflammation of the oral cavity and pharynx, as well as the nasal cavity and ears, the drug is prescribed in the amount of 2 tablets, the intake of which should be divided into 2 times. If the patient has serious respiratory complications, then you need to take 2 tablets 2 times a day.

For herpes and other types of infectious diseases of the oral cavity and skin, you need to take 2 tablets 3 times a day. The dosage of one tablet is 6 mg. The duration of prevention or treatment of diseases with tablets should not exceed 15 days.

Candles. The release form of Polyoxidonium in the form of suppositories comes in two dosages: 6 and 12 mg, respectively. A dosage of 6 mg is intended for preventive purposes, and 12 mg for therapeutic purposes. Suppositories can be inserted both into the rectum after preliminary emptying, and into the vagina if women have gynecological problems.

In the presence of chronic ailments, as well as allergies and for the purpose of preventing acute respiratory viral infections, it is recommended to use suppositories rectally. Initially, during the first three days it is necessary to use the medicine daily, and then it is necessary to do a 2-day interval. To prevent herpes, one 6 mg suppository should be administered every other day.

It is important to know! The course of treatment with suppositories lasts from 10 to 15 days.

If the patient has a tendency to a chronic form of immunodeficiency, then suppositories should be used in a dosage of 6 mg twice a week. This course of treatment can last from 2 to 12 months. If the patient has urological or gynecological problems, then 12 mg suppositories should be used every day for 3 days, and then switch to using suppositories every three days.

Polyoxidonium is effective in the fight against tuberculosis. For the prevention and treatment of tuberculosis, suppositories should be used at a dosage of 12 mg for 3 days, and then simplify the regimen and continue treatment every two days. When the main course ends, the doctor prescribes 6 mg suppositories 2 times a week for 2-3 months as a preventative measure.

Injections. For adults, doctors most often prescribe Polyoxidonium in the form of injections. Indications for injections are the following types of diseases:

• herpes;
• rheumatoid arthritis;
• inflammation of the respiratory and genitourinary systems;
• allergic diseases.

The scheme for using injections for such indications is as follows: the drug in an amount of 6 mg is administered intramuscularly every other day or 2 times a week. The duration of treatment is from 5 to 10 injections. Treatment regimens may differ, depending on the disease itself, its form and complications.

For acute signs of allergic diseases, Polyoxidonium in the form of injections is administered intravenously or a dropper is placed. If the patient has signs of renal failure, then no more than 2 injections per week are allowed. Important attention should be paid to the question of how to properly dilute the solution?

The solution is diluted immediately before the intramuscular injection procedure. The drug should not be stored in diluted form. The Polyoxidonium ampoule must be diluted with distilled water or saline solution. How to dilute the drug with these substances? To do this, you need to dilute Polyoxidonium 6 mg with one of these substances in an amount of 2 ml. If intravenous administration of the drug is planned, then Hemodez-N, Dextrose solution 5%, Reopolyglucin or simply saline solution are added to the solution. After all the substances are combined and thoroughly mixed, you can insert a dropper.

Is Polyoxidonium allowed for children?

When a doctor prescribes Polyoxidonium for a small child, parents have a considerable number of questions that doctors have to answer with the arrival of each new mother.

It should be noted that Polyoxidonium is widely used in pediatric practice. About 20 years ago, the drug went on sale, so during this period it has already managed to win the attention and trust of parents and doctors. The drug can be used for children from 6 months of age. This makes it clear that the drug is truly safe and is not capable of causing complications.

If a child is often more susceptible to respiratory diseases, this negatively affects the body’s protective function. The immune system weakens, the functioning of various human organs and systems is disrupted, and chronic or inflammatory processes develop. Viral respiratory diseases can cause serious complications in children, such as pneumonia, sinusitis, otitis media and even pyoderma.

To prevent viruses from causing serious complications, the doctor prescribes a course of treatment with immunomodulators. Treatment is prescribed only by a doctor, but not independently. If you choose the drug incorrectly, it will only lead to a deterioration in the child’s well-being. Polyoxidonium is one of the best immunomodulators, which has been tested not only by time, but also by experience. It is effective not only for the prevention and treatment of diseases in adults, but also in children. We will find out further how to use the drug correctly for children.

Rules for using Polyoxidonium for children

Drops. For children, a drug such as Polyoxidonium is best used in the form of drops. This application option is simple and painless. To begin with, the drops should be prepared correctly. To do this, add 20 drops of distilled water to the lyophilisate with a volume of 3 mg. After this, the solution should be thoroughly mixed and applied. This ready-made solution can be stored for a week in a cold place, but not frozen.

Drops are used in the following dosage:

• if the baby’s weight is up to 5 kg – 5 drops;
• with a weight of 5 to 10 kg – 10 drops;
• with a weight of 10 to 15 kg – 15 drops;
• with a weight of 15 to 20 kg - 20 drops.

Drops should be placed on the tongue or nose. The dosage indicated above is daily, but not one-time. The specified number of drops can be divided equally and dripped at regular intervals. The duration of treatment should not exceed 5-10 days.

Candles. This form of release, such as candles, is used for children only in rare cases. There are certain indications for this, for example, exacerbation of colds, herpes, or for the prevention of influenza and ARVI. Suppositories should be used every other day for 10 days.

Injections. Injections are given to children even less frequently than suppositories are given. The main indication for injections is exacerbation or complication of diseases and pathologies. For injections, ampoules of the drug are used in an amount of 3 mg. A bottle of Polyoxidation is mixed with saline solution and then injected intramuscularly. It is worth noting that intravenous administration is allowed only with the help of a dropper for children from 5-6 years old.

Immunomodulator injections are absolutely painless, but it is very important that the drug is administered slowly. Injections are given mainly every other day for 15 days.

Pills. Children are allowed to be treated with tablets from the age of 12. Prevention of chronic, acute and seasonal diseases is carried out according to the regimen of taking 1 tablet in the morning and evening for a week. Children are often advised to dissolve the tablet, but a more detailed method of administration should be checked with a doctor.

The effectiveness of Polyoxidonium in gynecology

Women very often encounter diseases of the genital organs. The reasons for this trend remain unclear, but at the next visit to the gynecologist, it is possible that new pathologies or abnormalities will be discovered. The most common female diseases are:

1. Endometritis.
2. Salpingitis.
3. Oophoritis.
4. Pelvic peritonitis.
5. Ovarian cysts.
6. Erosion.

Treatment with traditional methods using antibacterial drugs does not lead to recovery. This is due to various factors, but the main one is the lack of impact on local immunity. If you do not use immunomodulators that will help strengthen the immune system and create a protective barrier, this will lead to the progression of the disease and the development of complications. If you use Polyoxidonium for the treatment of gynecological diseases, you can achieve the following results:

• speed up the healing process;
• normalize reproductive function;
• reduce the number of pathogenic bacteria in the vaginal cavity;
• exclude the development of relapses;
• improve ultrasound performance.

It is important to know! It has been noted that women who periodically take courses of immunomodulators encounter gynecological and other types of diseases extremely rarely.

It is important to note the fact that immunomodulators create a protective barrier that prevents various pathogenic microorganisms, as well as fungi, from entering the body. Such a common problem as thrush can be eliminated by taking the immunomodulator Polyoxidonium.

Based on all of the above, we can summarize and note that Polyoxidonium is the best domestic immunomodulator, without the use of which it is simply not rational to treat various diseases. The drug is suitable for children, adults and even the elderly. It has practically no contraindications, but is quite effective for any pathologies.

Anything could happen, so I got used to not being cured the first time and even after the so-called recovery, walking around with a runny nose. Polyoxidonium is a new medicine for me, it helped almost instantly (on day 2, to be more precise), and after the course there were no complications or recurrences, as I assumed based on past experience. I have been without acute respiratory infections (even minor ones) for almost 8 months... This is the worst thing)

Everything is written correctly about the principle of operation. I have already experienced this myself. Polyoxidonium acts in three directions. It acts as an antiviral, as an antioxidant - relieves inflammation, and also as a detoxifier - removes viral toxins. And that's great! How many antiviral drugs do we have with such a complex effect?

My daughter started kindergarten last fall. She was sick all autumn and half of the winter: she went to kindergarten for two weeks, and was sick for two weeks. Even the doctor told us that we often get very sick and then prescribed polyoxidonium as an antiviral and for general strengthening of the immune system. I bought it for my daughter in tablets. After taking these pills as a course, ARVI suddenly disappeared. From January to May, my daughter has never been sick. Pah-pah.

When my son got sick and I called the pediatrician home, she prescribed me to buy polyoxidonium and said that this is a modern antiviral drug that has been tested and that it really helps. And having treated my son, I can say that this is true, no antiviral drugs have ever helped as well as this one.

So much has happened this year. Our sore throat began to become chronic, naturally I blamed myself for not saving the child, but fortunately polyoxidonium removed this issue for us. Although we drank it during acute respiratory infections, it helped with other problems. And now the sore throats have disappeared and the acute respiratory infections are not even coming, and only one course was enough

Polyoxidonium is an immunomodulator for activating the immune system and has a detoxifying effect. Increases the body's immune resistance against local and generalized infections. Restores immune responses in immunodeficiency states. The range of indications includes: correction of secondary immunodeficiencies; infectious and inflammatory diseases, incl. chronic recurrent (ENT organs, upper respiratory tract, urogenital, etc.); surgical infections; tuberculosis; allergic diseases with secondary immune deficiency; intestinal dysbiosis; rheumatoid arthritis; malignant neoplasms (during and after chemotherapy and radiation therapy); trophic ulcers, etc.

Compound

For 1 suppository: active substance: Polyoxidonium (Azoximer bromide) - 12 mg

Release form

Vaginal and rectal suppositories, 10 pieces per package

pharmachologic effect

Polyoxidonium has an immunomodulatory effect, increases the body's resistance to local and generalized infections. The basis of the mechanism of immunomodulatory action of Polyoxidonium is a direct effect on phagocytic cells and natural killer cells, as well as stimulation of antibody formation.

Polyoxidonium restores immunity in secondary immunodeficiency conditions caused by various infections, injuries, burns, autoimmune diseases, malignant neoplasms, complications after surgery, the use of chemotherapeutic agents, cytostatics, steroid hormones.

Along with the immunomodulatory effect, Polyoxidonium has pronounced detoxification and antioxidant activity, has the ability to remove toxins and heavy metal salts from the body, and inhibits lipid peroxidation.

These properties are determined by the structure and high-molecular nature of Polyoxidonium. The inclusion of Polyoxidonium in the complex therapy of cancer patients reduces intoxication during chemotherapy and radiation therapy, in most cases allows treatment without changing the standard therapy regimen due to the development of infectious complications and side effects (myelosuppression, vomiting, diarrhea, cystitis, colitis and others) . The use of Polyoxidonium against the background of secondary immunodeficiency states can increase the effectiveness and shorten the duration of treatment, significantly reduce the use of antibiotics, bronchodilators, glucocorticosteroids, and extend the period of remission.

The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.

Indications for use

In adults and children over 6 years of age in complex therapy to correct immune deficiency:

• chronic recurrent infectious and inflammatory diseases that are not amenable to standard therapy, both in the acute stage and in the remission stage;
• acute viral, bacterial and fungal infections;
• inflammatory diseases of the urogenital tract, including urethritis, cystitis, pyelonephritis, prostatitis, salpingoophoritis, endomyometritis, colpitis, cervicitis, cervicosis, bacterial vaginosis, including viral etiology;
• various forms of tuberculosis;
• allergic diseases complicated by recurrent bacterial, fungal and viral infections (including hay fever, bronchial asthma, atopic dermatitis);
• rheumatoid arthritis treated for a long time with immunosuppressants; with a complicated acute respiratory infection or acute respiratory viral infection;
• to activate regenerative processes (fractures, burns, trophic ulcers);
• for the rehabilitation of frequently and long-term (more than 4-5 times a year) ill persons;
• during and after chemotherapy and radiation therapy of tumors;
• to reduce the nephro- and hepatotoxic effects of drugs.

As monotherapy:

• for the prevention of recurrent herpetic infections;
• for seasonal prevention of exacerbations of chronic foci of infections; for the prevention of influenza and acute respiratory infections in the pre-epidemic period;
• for the correction of secondary immunodeficiencies resulting from aging or exposure to adverse factors.

Directions for use and doses

Polyoxidonium suppositories 6 mg and 12 mg are used rectally and vaginally once a day. The method and dosage regimen is determined by the doctor depending on the diagnosis, severity and severity of the process. Polyoxidonium can be used rectally and vaginally daily, every other day or 2 times a week.

• Polyoxidonium suppositories 12 mg are used rectally in adults, 1 suppository 1 time per day after bowel cleansing;

for gynecological diseases and vaginally, 1 suppository 1 time per day (at night) is inserted into the vagina in a lying position.

• Polyoxidonium suppositories 6 mg is used:

in children over 6 years old, 1 suppository rectally 1 time per day after cleansing the intestines;

in adults, rectally and vaginally as a maintenance dose, 1 suppository 1 time per day (at night) is inserted into the vagina in a lying position.

Standard regimen of use (unless otherwise prescribed by a doctor)

1 suppository 6 mg or 12 mg 1 time per day daily for 3 days, then every other day in a course of 10-20 suppositories. If necessary, the course of treatment is repeated after 3-4 months. For patients receiving immunosuppressive therapy for a long time, cancer patients with an acquired defect of the immune system - HIV, who have been exposed to radiation, long-term maintenance therapy with Polyoxidonium is indicated for 2-3 months to 1 year (adults 12 mg, children over 6 years old - 6 mg 1- 2 times per week).

Contraindications

• Increased individual sensitivity.
• Pregnancy, lactation (no clinical experience of use).

special instructions

Polyoxidonium is compatible with antibiotics, antiviral, antifungal and antihistamines, bronchodilators, glucocorticosteroids, and cytostatics.

Do not exceed the indicated doses and duration of treatment without consulting your doctor.

Storage conditions

In a dry place, protected from light, at a temperature of 2 to 15°C. Keep away from children.

ATX:

Pharmacological group

Nosological classification (ICD-10)

Composition and release form

In a blister pack 10 pcs.; in a cardboard pack 1 or 2 packages.

azoximer bromide 3 mg
excipients: mannitol; povidone; betacarotene - up to 4.5 mg

In ampoules or vials of colorless or dark neutral glass, 4.5 mg; in a cardboard pack there are 5 ampoules or bottles; or in a blister pack of 5 ampoules or bottles; in a cardboard pack 1 package; or in a cardboard pack of 5 ampoules or bottles complete with a solvent in ampoules (5 ampoules of water for injection or 5 ampoules of 0.9% isotonic sodium chloride solution).
Lyophilisate for the preparation of solution for injection and topical use 1 amp. or fl.
azoximer bromide 6 mg

In ampoules or vials of colorless or dark neutral glass, 9 mg; in a cardboard pack there are 5 ampoules or bottles; or in a blister pack of 5 ampoules or bottles; in a cardboard pack 1 package; or in a cardboard pack of 5 ampoules or bottles complete with a solvent in ampoules (5 ampoules of water for injection or 5 ampoules of 0.9% isotonic sodium chloride solution).
Suppositories 1 sup.
azoximer bromide 6 mg
excipients: mannitol; povidone; betacarotene - up to 9 mg

In a blister pack 5 pcs.; in a cardboard pack 2 packs.
Suppositories 1 sup.
azoximer bromide 12 mg
excipients: mannitol; povidone; betacarotene - up to 18 mg
base: cocoa butter - to obtain a suppository weighing 1.3 g

Description of the dosage form

Lyophilisate for the preparation of solution for injection and topical use: porous mass from white with a yellowish tint to yellow. The drug is hygroscopic and photosensitive.

Suppositories: torpedo-shaped, light yellow in color with a faint specific odor of cocoa butter.

pharmachologic effect

Pharmacokinetics

For suppositories: bioavailability - high (up to 70%); Cmax in the blood is achieved 1 hour after administration; T1/2 (fast phase - about 30 minutes, slow phase - 36.2 hours).

Pharmacodynamics

When administered sublingually, Polyoxidonium activates lymphoid cells located in the bronchi, nasal cavity, and Eustachian tubes, thereby increasing the resistance of these organs to infectious agents.

When administered orally, Polyoxidonium activates lymphoid cells located in the intestine, namely B-cells that produce secretory IgA. The consequence of this is an increase in the resistance of the gastrointestinal tract and respiratory tract to infectious agents. In addition, when administered orally, Polyoxidonium activates tissue macrophages, which facilitates faster elimination of the pathogen from the body in the presence of a focus of infection.

Along with the immunomodulatory effect, Polyoxidonium has pronounced detoxifying and antioxidant activity, which is determined by the structure and high-molecular nature of the drug. Increases the resistance of cell membranes to the cytotoxic effects of drugs and chemicals, reduces their toxicity.

The use of Polyoxidonium in complex therapy can increase the efficiency and shorten the duration of treatment, significantly reduce the use of antibiotics, bronchodilators, corticosteroids, and extend the period of remission.

The drug is well tolerated, does not have mitogenic activity, or antigenic properties; does not have allergenic, mutagenic, embryotoxic, teratogenic or carcinogenic effects.

Indications for the drug Polyoxidonium

In adults and adolescents over 12 years of age in complex therapy:
acute and chronic inflammatory recurrent bacterial, viral and fungal infections of the oral cavity, paranasal sinuses, upper respiratory tract, inner and middle ear.

In a group of immunocompromised adolescents and adults in the form of monotherapy (sublingual):
prevention of influenza and other acute respiratory infections in the pre-epidemic period.

Lyophilisate for the preparation of solution for injection and topical use. Correction of immune deficiency in adults and children.
In adults in complex therapy (6 mg):
chronic recurrent inflammatory diseases of any etiology that are not amenable to standard therapy, both in the acute stage and in the remission stage;
rheumatoid arthritis treated for a long time with immunosuppressants; or complicated by the occurrence of acute respiratory infections or acute respiratory viral infections;
acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);
tuberculosis;
acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by chronic recurrent bacterial and viral infections;
during and after chemotherapy and radiation therapy of tumors; to reduce the nephro- and hepatotoxic effects of drugs;
to activate regenerative processes (fractures, burns, trophic ulcers).

As monotherapy
for the prevention of postoperative infectious complications;
correction of secondary immunodeficiencies resulting from aging or exposure to adverse factors;
prevention of influenza and acute respiratory infections.

In children over 6 months of age in complex therapy (3 mg):
acute and chronic inflammatory diseases caused by pathogens of bacterial, viral, fungal infections (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, ARVI);
acute allergic and toxic-allergic conditions;
bronchial asthma complicated by chronic respiratory tract infections;
atopic dermatitis complicated by purulent infection;
intestinal dysbiosis (in combination with specific therapy);
for the rehabilitation of frequently and long-term ill children;
for the prevention of influenza and acute respiratory infections.

Suppositories:
In adults and children over 6 years of age in complex therapy (to correct immune deficiency):
for chronic recurrent inflammatory diseases of any etiology that are not amenable to standard therapy, both in the acute stage and in the remission stage;
acute and chronic viral and bacterial infections (including urethritis, cystitis, chronic pyelonephritis in the latent stage and in the acute stage, prostatitis, chronic salpingoophoritis, endometritis, colpitis; diseases caused by the papilloma virus; cervical ectopia; dysplasia and leukoplakia) ; various forms of tuberculosis;
allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by recurrent bacterial and viral infections; rheumatoid arthritis, long-term treatment with immunosuppressants; or complicated by the occurrence of acute respiratory infections or acute respiratory viral infections;
to activate regenerative processes (fractures, burns, trophic ulcers);
for the rehabilitation of frequently and long-term ill people (more than 4-5 times a year);
during and after chemotherapy and radiation therapy of tumors;
to reduce the nephro- and hepatotoxic effects of drugs.

As monotherapy:
for seasonal prevention of exacerbations of chronic foci of infections, incl. in elderly people;
for the prevention of recurrent herpetic infections;
for the correction of secondary immunodeficiencies resulting from aging or exposure to adverse factors;
for the prevention of influenza and acute respiratory infections.

Contraindications

With caution - acute renal failure.

Additionally, for lyophilisate for the preparation of solution for injection and topical use: with caution - children under 6 months of age (clinical experience of use is limited).

Use during pregnancy and breastfeeding

Side effects of the drug Polyoxidonium

Interaction

Directions for use and doses

Recommended treatment regimens for adults
Parenterally:
For acute inflammatory diseases: 6 mg daily for 3 days, then every other day with a general course of 5-10 injections.
For chronic inflammatory diseases: 6 mg every other day for 5 injections, then 2 times a week for a course of at least 10 injections.
For tuberculosis: 6 mg 2 times a week for a course of 10-20 injections.
For rheumatoid arthritis: 6 mg every other day - 5 injections, then 2 times a week for a course of at least 10 injections.
In patients with acute and chronic urogenital diseases: 6 mg every other day for a course of 10 injections in combination with chemotherapy.
For chronic recurrent herpes: 6 mg every other day for a course of 10 injections in combination with antiviral drugs, interferons and inducers of interferon synthesis.
For the treatment of complicated forms of allergic diseases: 6 mg, course of 5 injections - the first 2 injections daily, then every other day. For acute allergic and toxic-allergic conditions, administer 6-12 mg intravenously in combination with antiallergic drugs.
In cancer patients:
- before and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents, 6-12 mg every other day for a course of at least 10 injections;
- for the prevention of the immunosuppressive effect of the tumor, for the correction of immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor, long-term use of Polyoxidonium (from 2-3 months to 1 year) 6 mg 1-2 times a week is indicated.
In patients with acute renal failure, it is prescribed no more than 2 times a week.
Intranasal administration is prescribed for the treatment of acute and chronic infections of the ENT organs, to enhance the regenerative processes of the mucous membranes, to prevent complications and relapses of diseases, to prevent influenza and acute respiratory infections: 1-3 drops in each nasal passage after 2-3 hours (at least 3 -4 times a day) for 5-10 days. A dose of 6 mg is dissolved in 1 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature (20 drops) and use the solution for 24 hours.

For children. Methods of application are selected by the doctor depending on the diagnosis, severity of the disease, age and body weight of the patient.
Parenterally (IM or IV drip) at a dose of 0.1-0.15 mg/kg daily, every other day or 2 times a week for a course of 5-10 injections.
For intramuscular administration, the drug is dissolved in 1 ml of water for injection or 0.9% sodium chloride solution.
For intravenous drip administration, the drug is dissolved in 1.5-2 ml of a sterile 0.9% solution of sodium chloride, Polyglucin, Hemodez or 5% dextrose solution, sterilely transferred to a bottle with the indicated solutions with a volume of 150-250 ml.

Recommended treatment regimens for children
For acute inflammatory diseases: 0.1 mg/kg every other day for a course of 5-7 injections.
For chronic inflammatory diseases: 0.15 mg/kg 2 times a week for a course of up to 10 injections.
For acute allergic and toxic-allergic conditions: IV drip at a dose of 0.15 mg/kg in combination with antiallergic drugs.
For the treatment of complicated forms of allergic diseases in combination with basic therapy: IM 0.1 mg/kg in a course of 5 injections with an interval of 1-2 days.
Intranasally: daily at a daily dose of 0.15 mg/kg for 5-10 days.
The drug is administered intranasally, 1-3 drops into one nasal passage every 2-3 hours (at least 3-4 times a day).
To prepare a solution for intranasal and sublingual use, a dose of 3 mg is dissolved in 1 ml (20 drops), a dose of 6 mg is dissolved in 2 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. 1 drop of the prepared solution (50 μl) contains 0.15 mg of Polyoxidonium, which is prescribed per 1 kg of child’s body weight.
Sublingual: for all indications - daily at a daily dose of 0.15 mg/kg for 10 days, for the treatment of intestinal dysbiosis for 10-20 days.
Suppositories. Rectally (after cleansing the intestines), intravaginally. The method of administration and dosage regimen are determined by the doctor depending on the diagnosis, severity and severity of the process.
Polyoxidonium can be used daily, every other day or 2 times a week.
Polyoxidonium suppositories 12 mg are used rectally and intravaginally in adults.
Rectally: 1 supp once a day (after cleansing the intestines).
Intravaginally: the suppository is inserted into the vagina in the “lying” position once a day, at night.
Polyoxidonium suppositories 6 mg are used: in adults - rectally and intravaginally as a maintenance dose; in children over 6 years old - rectally at the rate of 0.20-0.25 mg/kg.
The standard regimen for using Polyoxidonium is 1 supp. 6 or 12 mg for 3 days, and then once every 2 days with a course of 10-15 supp. If necessary, the course of treatment is repeated after 3-4 months.
Patients with chronic immune deficiency (including cancer) are prescribed long-term (from 2-3 months to 1 year) maintenance therapy with Polyoxidonium: adults - 6-12 mg, children over 6 years - 6 mg 2 times a week.

Recommended regimens and doses
As part of complex therapy. Rectally.
For chronic recurrent inflammatory diseases in the acute stage - according to the standard scheme, in the remission stage - 1 supp. 12 mg every 1-2 days, with a total course of 10-15 supp.
For acute infectious processes - 1 sup. daily, with a general course of 10 administrations.
For tuberculosis - according to the standard regimen. The course of treatment is at least 15 supp., then it is possible to use maintenance therapy of 2 supp. per week for a course of 2-3 months.
For allergic diseases complicated by recurrent bacterial and viral infections - according to the standard regimen.
During and after chemotherapy and radiation therapy of tumors - 1 supp. daily 2-3 days before the start of therapy. Further, the frequency of administration of suppositories is determined by the doctor depending on the nature and duration of basic therapy.
To reduce the nephro- and hepatotoxic effects of drugs. The duration and regimen of suppositories is determined by the doctor depending on the basic therapy.
For the correction of secondary immunodeficiencies resulting from aging - 12 mg 2 times a week. Course - 10 sup.
For rehabilitation of frequent (more than 4-5 times a year) and long-term ill persons - 1 supp. in one day. Course of treatment - 10 supp.
For rheumatoid arthritis, long-term treatment with immunosuppressants - 1 supp. every other day with a total course of 15 injections; in case of complicated acute respiratory infections or acute respiratory viral infections of rheumatoid arthritis - according to the standard scheme.
To activate regenerative processes (fractures, burns, trophic ulcers) - 1 supp. daily. The course of treatment is 10-15 supp.
As monotherapy:
For seasonal prevention of exacerbations of chronic foci of infections, for the prevention of recurrent herpetic infections - every other day for adults - 6-12 mg, for children - 6 mg. Course - 10 sup.
For the correction of secondary immunodeficiencies, prevention of influenza and acute respiratory infections - according to the standard scheme.
For gynecological diseases (rectally or intravaginally) - 1 supp. (12 mg) for 3 days, and then 1 time every 2-3 days. The course of treatment is 10-15 sup.

special instructions

Shelf life of the drug Polyoxidonium

Storage conditions for the drug Polyoxidonium

Tamara 2019-02-25 17:48:48

The allergist prescribed polyoxidonium for allergic bronchial asthma, but I also take Singular tablets 10 mg once a day at night and Lozap in the morning. Is it possible to take polyoxidonium with these drugs together?

Valentina 2018-12-26 05:02:02

Hello. After hysteresectoscopy, the gynecologist prescribed vaginal longidase and rectal polyoxidonium suppositories. But I remembered that they need to be stored in the refrigerator, I kept them for 2 days at room temperature, can they be used?

Azamat 2018-10-30 11:27:22

Good afternoon! Tell me, in March I received a course of polyoxidonium injections for sinusitis, now I wanted to take polyoxidonium tablets to dissolve in the throat, is it possible to use the drug now if I already received injections in March?

Menshchikova Galina Vladimirovna Dermatovenerologist, dermato-oncologist. Candidate of Medical Sciences. Doctor of the first category. More than 15 years of experience answers:

Good afternoon. Yes, you can. Only these tablets dissolve under the tongue. There is an alternative drug - Panavir Inlight Spray.

Drugs with immunomodulatory effects may be prescribed to children with weakened immune systems to speed their recovery or prevent infections. Such drugs include Polyoxidonium, one of the forms of which is suppositories. Are they prescribed to children, how do they affect the human body and in what cases do they help?

Dosage form and composition

Polyoxidonium is a product of the Russian company Petrovax Pharm and, in addition to suppositories, is available in two other forms - vials with lyophilisate and tablets.

Polyoxidonium candles are characterized by an elongated shape, light yellow color and uniform structure. Due to the presence of cocoa butter, they have a unique aroma. The medicine is sold in boxes of 10 suppositories, and inside the package there are two blisters made of polyvinyl chloride shell containing 5 suppositories each.

The main component of the drug, like other forms, is azoximer bromide. In one suppository it is contained in a dose of 6 mg or 12 mg. In addition to cocoa butter, two more auxiliary ingredients have been added to the active substance - mannitol and povidone k17. They help create the desired structure of the suppository and prevent its deterioration during storage.

Operating principle

Polyoxidonium suppositories have a complex effect on the child’s body:

• The immunomodulatory effect of the drug is associated with the ability to increase the activity of natural killer cells and phagocytes, as well as stimulate the synthesis of interferons and antibodies.
• The antioxidant properties of the drug are due to its special structure, since due to its high-molecular nature, the azoximer intercepts free radicals.
• Suppositories have a detoxifying effect, as they are able to block various toxins and activate their elimination.
• The drug also has an anti-inflammatory effect, since it normalizes the ratio of cytokines.

Thanks to the use of suppositories, the body becomes more resistant to viral, bacterial, and fungal infections. In addition, the medication helps restore immunity in case of secondary immunodeficiencies caused by injury, surgery or infectious disease.

After introducing the suppository into the intestine, azoximer bromide is absorbed from it by approximately 70%, and after 1 hour, the concentration of this compound in the blood reaches its maximum. It affects different tissues, does not accumulate, and after conversion into low-molecular substances leaves the body in the urine.

Indications

If suppositories are prescribed for treatment, they are usually included in complex therapy of several drugs. For medicinal purposes, Polyoxidonium in this form is prescribed:

• in acute infectious and inflammatory diseases of different nature (caused by bacteria, fungus or virus) and different localization;
• for chronic infections with relapses during their exacerbation;
• with an inflammatory process that is localized in the pelvic organs, for example, with cystitis or urethritis;
• with tuberculosis in various forms;
• when an allergic disease is complicated by infection, for example, atopic dermatitis;
• to accelerate tissue regeneration processes in case of trophic ulcers, burns or fractures;
• when complicated by infection of rheumatoid arthritis;
• during radiation therapy or chemotherapy of oncological processes.

If Polyoxidonium in suppositories is prescribed for prophylaxis, then You can use monotherapy (take only this drug) to prevent:

• flu infection;
• recurrence of herpetic lesions of the genitourinary tract;
• exacerbation of chronic infection;
• development of ARVI during the epidemic of such diseases;
• the occurrence of secondary immunodeficiency.

At what age is it prescribed?

In children, only suppositories with a dosage of 6 mg can be used. This Polyoxidonium is allowed from 6 years of age.

If it is necessary to prescribe the drug to a younger child, for example, at 4 or 5 years old, suppositories are replaced with lyophilisate (it can be dripped or injected from the age of six months) or tablets (they are prescribed to children over 3 years old).

Contraindications

Polyoxidonium is not used if the child has:

• intolerance to azoximer bromide or another component of the suppositories has been identified;
• were diagnosed with acute renal failure.

If a young patient has chronic renal failure, the issue of treatment with Polyoxidonium is decided individually.

Side effects

Some patients experience redness or swelling of the area around the anus or severe itching after insertion of the suppository. This is how hypersensitivity to the drug manifests itself, therefore, if these symptoms occur, Polyoxidonium is immediately discontinued.

Instructions for use

Although suppositories are both rectal and vaginal, in childhood such Polyoxidonium is used only rectally. The suppository is inserted into the rectum after natural bowel movements or an enema. A single dosage for a child over six years of age is one suppository with 6 mg of azoximer bromide.

Application regimens differ depending on the reason for prescription. Most often the medicine is used daily for 10 days, that is, the course is 10 suppositories. This scheme is in demand for acute infectious diseases, allergies, injuries, exacerbation of urological pathologies, burns or trophic skin lesions.

This is exactly how suppositories are prescribed in order to prevent ARVI or influenza during the winter and spring period, when the epidemiological situation is unfavorable.

No less common is the scheme in which candles are placed for three days in a row, and then continued every other day. This course also includes 10 suppositories and is most often used to treat exacerbations of chronic foci of infection, for example, tonsillitis.

According to a similar scheme, pulmonary tuberculosis is treated with Polyoxidonium, but the total course includes 20 suppositories, and after its completion, the medication can be prescribed for maintenance, 1 suppository 2 times a week for 2-3 months.

If a child has rheumatoid arthritis complicated by infection, then suppositories are given every other day in a course of 10 suppositories. The same 20-day regimen is also used to prevent exacerbations of chronic infectious diseases or herpes.

Patients prescribed treatment for cancer begin to administer Polyoxidonium 1 suppository 2-3 days before the start of chemotherapy or radiation therapy, and then use the medication 2 times a week. The entire course is usually 10 candles.

Overdose and drug interactions

Exceeding the dose of Polyoxidonium in suppositories does not occur, since several suppositories are not used at the same time. As for compatibility with other drugs, the manufacturer notes the possibility of combining Polyoxidonium with many other drugs, including antibiotics, antihistamines or antiviral drugs.

Terms of sale and storage

Polyoxidonium in suppositories is an over-the-counter drug and is therefore freely sold in many pharmacies. On average, one package of suppositories costs 850-900 rubles.

The shelf life of the medicine is marked on the box and is 2 years. Candles should be stored at home in a cool place at a temperature of +2+15 degrees Celsius.

Compound

Active substance: Polyoxidonium® (Azoximer bromide) - 3 mg or 6 mg Excipients: mannitol, povidone, betacarotene - up to 4.5 mg for a 3 mg dosage or up to 9 mg for a 6 mg dosage.

Description

porous mass from white with a yellowish tint to yellow. The drug is hygroscopic and photosensitive.

pharmachologic effect

Polyoxidonium has an immunomodulatory effect, increases the body's resistance to local and generalized infections. The basis of the mechanism of immunomodulatory action of the drug Polyoxidonium® is a direct effect on phagocytic cells and natural killer cells, as well as stimulation of antibody formation.

Polyoxidonium® restores immunity in secondary immunodeficiency conditions caused by various infections, injuries, burns, autoimmune diseases, malignant neoplasms, complications after surgery, the use of chemotherapeutic agents, cytostatics, steroid hormones.

Along with the immunomodulatory effect, Polyoxidonium® has pronounced detoxification and antioxidant activity, has the ability to remove toxins and heavy metal salts from the body, and inhibits lipid peroxidation. These properties are determined by the structure and high-molecular nature of the drug Polyoxidonium®. Its inclusion in the complex therapy of cancer patients reduces intoxication during chemotherapy and radiation therapy, and in most cases allows for standard therapy without changing the regimen due to the development of infectious complications and side effects (myelosuppression, vomiting, diarrhea, cystitis, colitis and others).

The use of the drug Polyoxidonium® against the background of secondary immunodeficiency states can increase the effectiveness and shorten the duration of treatment, significantly reduce the use of antibiotics, bronchodilators, glucocorticosteroids, and extend the period of remission.

The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effects.

Pharmacokinetics

In the body, the drug is hydrolyzed to oligomers, which are excreted primarily by the kidneys.

Indications for use

Correction of immunity in adults and children from 6 months.

In adults in complex therapy:

Chronic recurrent infectious and inflammatory diseases that are not amenable to standard therapy in the acute stage and in remission;

Acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);

Tuberculosis;

Acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by chronic recurrent bacterial and viral infections;

In oncology, during and after chemotherapy and radiation therapy to reduce the immunosuppressive, nephro- and hepatotoxic effects of drugs;

To activate regenerative processes (fractures, burns, trophic ulcers);

Rheumatoid arthritis treated for a long time with immunosuppressants; with rheumatoid arthritis complicated by acute respiratory infections;

For the prevention of postoperative infectious complications;

For the prevention of influenza and acute respiratory infections

In children in complex therapy:

Acute and chronic inflammatory diseases caused by pathogens of bacterial, viral, fungal infections (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, ARVI);

Acute allergic and toxic-allergic conditions;

Bronchial asthma complicated by chronic respiratory tract infections;

Atopic dermatitis complicated by purulent infection;

Intestinal dysbiosis (in combination with specific therapy);

For the rehabilitation of those who are often and long-term ill;

Prevention of influenza and acute respiratory infections.

Contraindications

Increased individual sensitivity. Pregnancy, lactation (no clinical experience of use).

Acute renal failure, children under 6 months of age (clinical experience of use is limited).

Pregnancy and lactation

Not studied.

Directions for use and doses

Methods of using the drug Polyoxidonium®: parenteral, intranasal. Methods of application are selected by the doctor depending on the severity of the disease and the age of the patient.

Intramuscularly or intravenously (drip): the drug is prescribed to adults in doses of 6-12 mg 1 time per day every day, every other day, or 1-2 times a week, depending on the diagnosis and severity of the disease.

The prepared solution for parenteral administration cannot be stored.. Intranasal: a dose of 6 mg is dissolved in 1 ml (20 drops) of distilled water, 0.9% sodium chloride solution or boiled water at room temperature.

Parenterally:

For acute inflammatory diseases: 6 mg daily for 3 days, then every other day with a total course of 5-10 injections.

For chronic inflammatory diseases: 6 mg every other day for 5 injections, then 2 times a week for a course of at least 10 injections.

For tuberculosis: 6-12 mg 2 times a week for a course of 10-20 injections.

In patients with acute and chronic urogenital diseases: 6 mg every other day for a course of 10 injections in combination with chemotherapy.

For chronic recurrent herpes: 6 mg every other day for a course of 10 injections in combination with antiviral drugs, interferons and/or inducers of interferon synthesis.

For the treatment of complicated forms of allergic diseases: 6 mg, course of 5 injections: the first two injections daily, then every other day. For acute allergic and toxic-allergic conditions, administer 6-12 mg intravenously in combination with antiallergic drugs.

For rheumatoid arthritis: 6 mg every other day for 5 injections, then 2 times a week for a course of at least 10 injections.

In cancer patients:

Before and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents, 6-12 mg every other day for a course of at least 10 injections; further, the frequency of administration is determined by the doctor depending on the tolerability and duration of chemotherapy and radiation therapy;

To prevent the immunosuppressive effect of the tumor, to correct immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor, long-term use of the drug Polyoxidonium® (from 2-3 months to 1 year) at a dose of 6-12 mg 1-2 times a week is indicated.

6 mg per day is prescribed intranasally for the treatment of acute and chronic infections of the JIOP organs, to enhance the regenerative processes of the mucous membranes, to prevent complications and relapses of diseases, to prevent influenza and acute respiratory infections. 3 drops in each nasal passage every 2-3 hours (3 times a day) for 5-10 days.

Patients with impaired renal function: in the presence of acute renal failure, the drug is prescribed no more than 2 times a week.

Patients with impaired liver function: no clinical studies have been conducted

Side effect

Possible pain at the injection site when administered intramuscularly.