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Fastum gel is a product for external use. It is colorless, has an almost uniform consistency and does not have a very pronounced pleasant odor. The unique composition of the product is selected in such a way that the gel does not simply mask unpleasant painful signs, creating the illusion of relief. When applied to the affected area, it effectively eliminates the very cause of pain, relieves inflammation and thereby relieves pain.

The main active component of the gel is ketoprofen. This component is a non-steroidal anti-inflammatory substance. Its analgesic effect is the highest in the corresponding subgroup. If you compare the molecules of piroxicam, nimesulide, diclofenac and ketoprofen, you can see that the latter has the smallest. The molecular weight of ketoprofen is only 254.29 g/mol (for the same nimesulide, for comparison, 308.311 g/mol). It is thanks to this that the fastest penetration into the source of inflammation through the skin is ensured. Once inside, Ketoprofen minimizes the synthesis of prostaglandins in the affected tissues - specific substances that directly affect the development of pain and inflammation.

Each tube contains 2.5% ketoprofen. This percentage ratio was not chosen by chance: according to numerous studies, this is the volume that is necessary to ensure a rapid analgesic effect. A higher percentage of active substance would not improve the quality of treatment.

The substance ketoprofen has a number of properties:

• anti-inflammatory: rapid relief of inflammation in affected tissues by eliminating its cause;
• antipyretic: reducing the temperature in the affected area;
• analgesic: eliminates the feeling of pain, acting directly on its very cause;
• anti-exudative: eliminates excessive vascular permeability at the site of inflammation and prevents the release of fluid (exudate) into the tissue.

The bioavailability of ketoprofen is only 5%. If you apply 50-150 mg of the product to the surface of the skin and rub it into the skin, then its concentration in the blood after 6-8 hours will be only 0.08-0.15 mg/ml. Thanks to this, ketoprofen remains in the affected tissues for a long time - 6-8 hours. During this period, the drug provides a therapeutic effect.

Another advantage of this active component is that it does not accumulate in body tissues and is excreted by the kidneys within 1-3 hours. The therapeutic effect does not depend on the gender or age of the person.

Let's look at the additional components included:

1. Ethanol 96% is a monohydric alcohol that is widely used in medicine. In addition to the fact that it itself is an excellent disinfectant, in this case it acts as a preservative.
2. Triethanolamine is a chemical substance of the amino alcohol class with excellent concentrating properties. The product with this component can only be used externally; it is non-toxic and hypoallergenic. Acting as an emulsifier, triethanolamine helps the other components combine with each other and act most effectively.
3. Carbomer 940 is a thickener used to thicken gels. By itself, this substance is capable of restoring acidity in medicines and cosmetics.
4. Neroli oil is the most expensive essential oil obtained from the flowers of bitter orange or bitter orange. It consists of tiny molecules that easily penetrate skin cells. Its properties, among others, include the ability to relieve swelling and stimulate metabolic processes in tissues.
5. Lavender oil is a natural antiseptic that has a complex structure of more than 150 components. Thanks to this, it perfectly relieves spasms, soothes, and stimulates. Among its medicinal properties, it relieves muscle and joint pain, helps with radiculitis and rheumatism.
6. Purified water.

Application

Fastum gel is intended exclusively for external use. It is applied to the affected area in an even thin layer. It is important to identify the painful area here. If it is the elbow joint, an area of ​​3-5 cm is sufficient; if it is the knee joint, the area will be slightly larger, approximately 5-10 cm.

An undoubted advantage is that when on the surface of the skin, Fastum gel does not cause a burning sensation (therefore even people with hypersensitive skin can use it), pleasantly cools and relieves pain.

Despite all the beneficial qualities, the effect of Fastum gel does not affect the body. In particular, there is no effect on the stomach, liver or kidneys.

The product is very convenient to use. You don't need any compresses or bandages, just rub the gel into the skin. At the same time, clothes will not get dirty due to the rapid absorption of the product.

Since the gel contains water and alcohol, it can be used during physiotherapy.

Rules of use:

• Before application, ensure that the skin is clean and dry. If you take a warm bath before application, this will ensure the fastest and easiest penetration of the components to the affected area, because the blood vessels will be dilated. Thus, pain relief will occur much faster.
• It is recommended to use the gel twice a day, rubbing it evenly into the skin. You can perform procedures for no more than 10 days in a row, maximum 2 weeks.

Due to the fact that the absorption of the active components is minimal, an overdose is impossible. If somehow the gel gets inside, then gastric lavage may be required. A large amount of gel ingested can provoke the development of systemic side effects. The same applies to getting the product into the eyes. If this happens, you need to rinse them thoroughly with plenty of running water. Otherwise, irritation of the conjunctiva of the eye may develop.

Before using the gel, it is important to read the instructions. After rubbing the gel in, be sure to wash your hands. It is forbidden to apply the drug to areas of skin with open, purulent wounds, or areas of inflammation. Also, the gel is not used under bandages and closed tight clothing.

When treating Fastum gel, it is better to avoid exposure to direct sunlight and visits to the solarium. The same applies to two weeks after stopping treatment.

If any alarming uncharacteristic reactions on the skin begin to appear, you need to stop treatment and consult a doctor.

Fastum gel does not have a negative effect on a person’s concentration, so it can be used by drivers and people whose activities require reaction speed.

Indications for use

Main indications:

1. Injuries of various origins. This can be a regular bruise when the muscles and subcutaneous fat layer are damaged. The body responds to damage with a kind of protective reaction - inflammation. As a result, pain and swelling occurs. If an arm or leg has been injured, it may be difficult to move. In such cases, ice is applied - this helps ensure the drainage of lymph from the site of the injury and avoid bruising. You also need to limit the mobility of the limb and immediately apply Fastum gel. After some time, you can apply a pressure bandage. In cases with sprains, the same algorithm applies.
2. Muscle pain. You can simply pull your back or neck with a sudden careless movement. It is important to allow the muscles to relax. The sore spot can be provided with heat, this will help the muscles contract faster. And to relieve pain and inflammation, you need to apply Fastum gel in the first 15 minutes. Usually this is enough for everything to go away in 1-2 days. If the muscles have been overloaded as a result of intense training, they make themselves felt with pain of varying intensity. As a result of stress, lactic acid is released in the muscles and if there is a lot of it, then soreness is felt immediately after training. This is the so-called desired result, meaning that the muscles “grow”. But if the pain appears later, for example, after a day, then this indicates the presence of microtraumas in the muscles. You can help your muscles recover with Fastum Gel, which will quickly relieve pain caused by microtraumas.
3. Joint pain. It is important to make sure there is no fracture or dislocation. In case of dislocations and fractures, medical intervention cannot be avoided - it is very important to return the limb to the correct position in time. In this case, Fastum gel may be needed to relieve pain and swelling that will not go away quickly. The drug is also prescribed to speed up the healing process. In case of a fracture, the gel will help relieve discomfort after removing the plaster.
4. Fastum gel is used for neuralgia, myalgia, pain in the spine, diseases of an inflammatory-degenerative nature (tendonitis, lumbago), as part of complex therapy for the treatment of diseases of the veins, lymphatic vessels and nodes.

Contraindications

Like any other product, Fastum gel has its contraindications. These include:

• intolerance specifically to ketoprofen or any other similar component from the NSAID group;
• intolerance to at least one of the auxiliary components;
• skin hypersensitivity to ultraviolet radiation;
• the presence of allergic reactions;
• the presence of dermatoses, rashes, open and purulent wounds and eczema on the skin at the site of the lesion;
• not prescribed for children under 12 years of age;
• pregnancy and lactation. Fastum gel cannot be used in the 3rd trimester, in the 1st and 2nd trimester only in special cases when the benefit to the mother outweighs the possible harm to the child. During lactation, if there is a need for such treatment, it is worth stopping feeding for a while.

Patients with impaired liver, kidney and gastrointestinal function should use Fastum gel with extreme caution (under monitoring the functions of these organs). The same applies to patients who have recently undergone surgery. Old age also requires careful handling of Fastum Gel.

Side effects, overdose

When using Fastum gel, any negative manifestations are very rarely observed. In rare cases, a rash, itching and burning may occur at the application site. Sometimes the treated area of ​​skin becomes susceptible to ultraviolet radiation. Allergic reactions can be in the form of urticaria and anaphylactic manifestations. Quite rarely, side effects occur in the form of diarrhea and worsening renal failure.

There have been no cases of overdose in practice due to the low absorption of the active component - ketoprofen.

Interaction with other drugs

Fastum gel can enhance the effect of drugs that cause photosensitivity. You should not use Fastum gel simultaneously with other NSAIDs - there is a risk of developing erosions and ulcers of the gastrointestinal tract.

The component ketoprofen may reduce the effect of antihypertensive drugs. When used with diuretics, the development of renal failure is likely. Together with thrombolytics, Heparin and Ticlopidine, the possibility of bleeding cannot be excluded.

Analogues and price

Cheaper analogues of Fastum Gel are preparations for external use such as Ketoprofen, Febrofid,. Their cost ranges from 100 rubles. Fastum gel itself can cost from 250 to 550 rubles per tube, it depends on its volume.

“Fastum Gel” is a drug that has an analgesic, anti-inflammatory effect and is used in the treatment of inflammatory diseases and pain relief in various pathological conditions.

Instructions for use

The drug is available in the form of a gel for external use. One hundred grams of the drug "Fastum Gel" contains 2.2 grams of the active substance ketoprofen. The auxiliary components include: ethyl alcohol, carbomer 940, lavender oil, Neroli oil, distilled water, diethanolamine.

The medicine is available in aluminum tubes of 100, 50 or 30 grams, and is packaged in cardboard boxes.

Beneficial features

The mechanism of action of the drug "Fastum Gel" is based on inhibition of prostaglandin synthesis. The active substance ketoprofen has a pronounced anti-inflammatory and analgesic effect.

Penetrating through the skin, it quickly reaches the inflammatory focus, thereby providing the possibility of local therapy for lesions (muscles, tendons, joints, ligaments) that are accompanied by pain.

If we note the peculiarities of pharmacokinetics, we can say that the drug directly penetrates the skin when used locally, absorption of the active substance from the inflammatory focus occurs rather slowly (the bioavailability of the gel does not exceed 5%).

After using ketoprofen in a dose of 50-150 milligrams, after 5-8 hours the concentration in the blood is approximately 0.08-0.15 micrograms per milliliter.

The drug practically does not accumulate in the body. Its half-life reaches 1-3 hours. The binding rate of ketoprofen to blood proteins is 60-90%. The drug "Fastum Gel" is predominantly excreted through the kidneys in the form of a glucuronide metabolite.

Indications for use

The drug "Fastum Gel" is used to treat:

• stiffness and tension in the neck muscles;
• pain of traumatic origin (sprains of muscles and ligaments, bruises);
• osteoarticular and muscle pain of a rheumatic nature (for example, osteoarthritis);
• lumbago (pain syndrome in the lumbosacral region).

Contraindications

The following contraindications to the use of the drug are identified:

• individual increase in sensitivity to the active component or other components of the drug, acetylsalicylic acid and any other non-steroidal anti-inflammatory drugs (history of urticaria, bronchospasm, rhinitis caused by the use of acetylsalicylic acid), as well as fenofibrate;
• skin hypersensitivity to sunlight (photosensitivity);
• the presence of skin allergies to tiaprofenic acid, ketoprofen, sunscreens, fenofibrate, perfumes;
• exposure to sunlight on the treated areas, including solariums directly during treatment with the drug and for two weeks immediately after stopping the course of treatment;
• eczema, weeping dermatoses, wounds (directly in the place where the gel is applied), infected abrasions;
• age up to twelve years (safety and effectiveness indicators during this period are unstudied);
• lactation period and pregnancy.

The drug "Fastum Gel" should be used with caution in the presence of severe renal failure and in old age.

Dosage and method of use

The drug is intended for external use only. When using a tube, a strip of gel from five to ten centimeters long must be applied in a thin layer to the affected area or to the skin directly above the source of inflammation up to two times a day, then lightly rubbed in.

When using a container with a dispenser, you need to press twice on its dome or base until a gel is obtained. It is recommended to keep the container in a horizontal position. The gel is applied to the affected area or over the inflammatory focus in a thin layer up to two times a day, then lightly rubbed in.

The amount of medicinal substance applied is determined by the size of the treated area. The drug can also be used in combination with physiotherapy (phonophoresis, iontophoresis). The average course of therapy is ten days.

Side effects

The use of the drug can sometimes be accompanied by the development of side effects. On the skin side, eczema, itching, erythema may occur; bullous dermatitis, photosensitivity, urticaria, angioedema, and contact dermatitis are rarely observed.

Peptic ulcers, bleeding, and diarrhea may develop in the stomach and intestines. In rare cases, the use of the drug is accompanied by the development of anaphylactic reactions and hypersensitivity reactions. The drug can sometimes aggravate the course of renal failure.

Overdose

The extremely low rate of systemic absorption of the active components of the drug when used topically makes overdose impossible.

If you accidentally take a significant amount of Fastum Gel, systemic side effects may develop. To eliminate such conditions, symptomatic treatment is carried out.

Interaction with drugs belonging to other pharmacological groups

When ketoprofen is used externally in gel form, it is possible to enhance the activity of drugs that cause photosensitivity. No other interactions have been established to date. However, all patients who take coumarin anticoagulants are recommended to constantly monitor the INR (international normalized ratio).

Price

The price of the drug "Fastum Gel" in Russia ranges from 177 rubles to 594 rubles, and it is determined by the manufacturer, release form and quantity of the drug.

In Ukraine, prices for this drug also vary greatly, starting from 31 hryvnia and reaching 110 hryvnia. In this case, the manufacturing company, the type of packaging and quantity of the drug, and its release form also play a role.

Analogs

There are a large number of analogues of the drug "Fastum Gel". They differ in the content of the active substance ketoprofen, in their pharmacological properties, and in their dosage and application.

The cheapest analogue can be called the drug "Ketoprofen". It is indicated for swelling, chronic back pain, bruises, and sports injuries. Another medicine can be called “Fort gel”. One gram of this drug contains twenty-five thousandths of ketoprofen, it also contains carbomer, ethyl alcohol, and triethanolamine. It is used for diseases of the skin, lymph nodes, veins, joints, and bruises.

Other drug analogs of “Fastum Gel” include “Ketoprom”, “Bystrum Gel”, “Ortofen”, “Vulusal Gel”, “Atrum Gel”, “Ferbofid Gel”, “Oruvel Gel”, “Bioran Gel” ( the active substance is diclofenac), "Butadione" (active substance - phenylbutazone), "Deep Relief gel" (active components levomenthol and ibuprofen), "Nise gel" (based on nimesulide).

Fastum gel - a fresh description of the medication. You can read contraindications, side effects, dosage of the drug Fastum gel. Useful reviews about Fastum gel -

NSAID, propionic acid derivative.
Drug: FASTUM®
Active substance of the drug: ketoprofen
ATX encoding: M02AA10
KFG: NSAIDs for external use
Registration number: P No. 012306/01
Registration date: 09.16.05
Owner reg. credential: A.MENARINI INDUSTRIE FARMACEUTICHE RIUNITE S.r.L. (Italy)

Release form Fastum gel, drug packaging and composition.

Gel for external use 2.5% is colorless, almost transparent, viscous, with a pleasant odor.

1 g
ketoprofen
25 mg

Excipients: carbomer 940, ethanol, neroli oil, lavender oil, triethanolamine, purified water.

30 g - aluminum tubes (1) - cardboard packs.
50 g - aluminum tubes (1) - cardboard packs.

DESCRIPTION OF THE ACTIVE SUBSTANCE.
All information provided is provided for information only about the drug; you should consult your doctor about the possibility of use.

Pharmacological action Fastum gel

NSAID, propionic acid derivative. It has analgesic, anti-inflammatory and antipyretic effects. The mechanism of action is associated with inhibition of the activity of COX, the main enzyme in the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.

The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system, as well as the effect on the biological activity of other neurotropic substances that play a key role in the release of pain mediators in the spinal cord). brain). In addition, ketoprofen has antibradykinin activity, stabilizes lysosomal membranes, and causes significant inhibition of neutrophil activity in patients with rheumatoid arthritis. Suppresses platelet aggregation.

Pharmacokinetics of the drug.

When taken orally and rectally, ketoprofen is well absorbed from the gastrointestinal tract. Cmax in plasma when administered orally is achieved after 1-5 hours (depending on the dosage form), with rectal administration - after 45-60 minutes, intramuscular administration - after 20-30 minutes, intravenous administration - after 5 minutes.

Plasma protein binding is 99%. Due to its pronounced lipophilicity, it quickly penetrates the BBB. Css in blood plasma and cerebrospinal fluid persists from 2 to 18 hours. Ketoprofen penetrates well into the synovial fluid, where its concentration 4 hours after administration exceeds that in plasma.

Metabolized by binding to glucuronic acid and, to a lesser extent, by hydroxylation.

It is excreted mainly by the kidneys and to a much lesser extent through the intestines. T1/2 of ketoprofen from plasma after oral administration is 1.5-2 hours, after rectal administration - about 2 hours, after intramuscular administration - 1.27 hours, after intravenous administration - 2 hours.

Indications for use:

Articular syndrome (rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, gout); symptomatic treatment of inflammatory and degenerative diseases of the musculoskeletal system (periarthritis, arthrosynovitis, tendonitis, tenosynovitis, bursitis, lumbago), pain in the spine, neuralgia, myalgia. Uncomplicated injuries, in particular sports injuries, sprains, sprains or ruptures of ligaments and tendons, bruises, post-traumatic pain. As part of combination therapy for inflammatory diseases of the veins, lymphatic vessels, lymph nodes (phlebitis, periphlebitis, lymphangitis, superficial lymphadenitis).

Dosage and method of administration of the drug.

They are set individually, taking into account the severity of the disease. For oral administration in adults, the initial daily dose is 300 mg in 2-3 divided doses. For maintenance treatment, the dose depends on the dosage form used. For the treatment of acute conditions or relief of exacerbation of a chronic process, 100 mg is administered as a single intramuscular injection. Next, ketoprofen is administered orally or rectally.

Externally - applied to the affected surface 2 times a day.

Maximum dose: when taken orally or rectally - 300 mg/day.

Side effects of Fastum gel:

From the digestive system: pain in the epigastric region, nausea, vomiting, constipation or diarrhea, anorexia, gastralgia, liver dysfunction; rarely - erosive and ulcerative lesions of the gastrointestinal tract, bleeding and perforation of the gastrointestinal tract.

From the central nervous system: headache, dizziness, tinnitus, drowsiness.

From the urinary system: renal dysfunction.

Allergic reactions: skin rash; rarely - bronchospasm.

Local reactions: when used in the form of suppositories, irritation of the rectal mucosa and painful bowel movements are possible; when used in gel form - itching, skin rash at the site of application.

Contraindications to the drug:

For oral administration: erosive and ulcerative lesions of the gastrointestinal tract in the acute phase, “aspirin triad”, severe dysfunction of the liver and/or kidneys; III trimester of pregnancy; age up to 15 years (for retard tablets); hypersensitivity to ketoprofen and salicylates.

For rectal use: history of proctitis and rectal bleeding.

For external use: weeping dermatoses, eczema, infected abrasions, wounds.

Use during pregnancy and lactation.

Contraindicated for use in the third trimester of pregnancy. In the first and second trimesters of pregnancy, the use of ketoprofen is possible in cases where the potential benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to use ketoprofen during lactation, it is recommended to stop breastfeeding.

Special instructions for use of Fastum gel.

Use with extreme caution in patients with liver and kidney diseases, a history of gastrointestinal diseases, dyspeptic symptoms, and immediately after major surgical interventions. During treatment, systematic monitoring of liver and kidney function is necessary.

Interaction of Fastum gel with other drugs.

When ketoprofen is used simultaneously with other NSAIDs, the risk of developing erosive and ulcerative lesions of the gastrointestinal tract and bleeding increases; with antihypertensive drugs (including beta-blockers, ACE inhibitors, diuretics) - their effect may be reduced; with thrombolytics - increased risk of bleeding.

When used simultaneously with acetylsalicylic acid, it is possible to reduce the binding of ketoprofen to plasma proteins and increase its plasma clearance; with heparin, ticlopidine - increased risk of bleeding; with lithium preparations - it is possible to increase the concentration of lithium in the blood plasma to toxic levels due to a decrease in its renal excretion.

When used simultaneously with diuretics, the risk of developing renal failure increases due to a decrease in renal blood flow caused by inhibition of prostaglandin synthesis and against the background of hypovolemia.

When used simultaneously with probenecid, the clearance of ketoprofen and its binding to plasma proteins may be reduced; with methotrexate – the side effects of methotrexate may increase.

With the simultaneous use of warfarin, severe, sometimes fatal bleeding may develop.

For external use.

The drug is a derivative of propionic acid. The gel has a pronounced analgesic and anti-inflammatory effect.

Additionally, the medication produces an antipyretic effect.

The list of main indications for the use of Fastum Gel includes degenerative-inflammatory pathologies of the musculoskeletal system and joint diseases accompanied by pain.

In some cases, the drug is prescribed for the complex treatment of diseases of the veins and lymph nodes. In pediatric practice, the drug has age restrictions.

Instructions for use

The mechanism of action of Fastum gel and the pharmacological properties of the drug are described in the instructions. Possible side effects, features of drug interactions with other pharmaceuticals, and regimens for use in various pathologies are noted in separate paragraphs. Additionally, the manufacturer describes special instructions that must be taken into account for special groups of patients (for example, with kidney or liver dysfunction, hereditary diseases, etc.).

pharmachologic effect

The action of the gel is aimed at inhibition of COX activity. This group of enzymes are precursors of prostaglandins. This property of the drug allows it to act on the source of inflammation or pain, quickly relieving the corresponding symptoms of the pathology.

The drug helps eliminate joint and muscle pain of various origins, inhibits inflammatory processes in the veins and the progression of neuralgic disorders.

Pharmacological properties:

• inhibition of prostaglandin synthesis;
• inhibition of neutrophil activity;
• pain relief;
• suppression of platelet aggregation;
• accelerating the tissue healing process;
• antipyretic effect;
• antibradykinin activity;
• reducing the intensity of the inflammation process.

Composition and release form

Fastum gel Available in the form of a product for external use. The transparent mass has a viscous consistency and a pleasant smell. The gel is placed in aluminum tubes of 100, 50 or 30 g. Additionally, the drug is packaged in a cardboard box.

The active ingredient in Fastum gel is ketoprofen.

Excipients:

• lavender oil;
• ethanol;
• purified water;
• carbomer 940;
• neroli oil;
• trolamine

Indications for use

The gel is used for manifestations of articular syndrome, progression of inflammatory and degenerative pathologies associated with the musculoskeletal system and pain caused by damage to bone or muscle tissue.

In some cases, the drug is prescribed as an adjunct to the treatment of diseases of the veins or lymph nodes (superficial lymphadenitis, lymangiitis or phlebitis).

Indications for use:

• neuralgic disorders;
• ligament rupture and sprain;
• trauma and post-traumatic syndrome;
• periarthritis and bursitis;
• dislocations and bruises of varying severity;
• rheumatoid arthritis;
• myalgia;
• arthrosynovitis and tenosynovitis;
• gout.

Directions for use and standard dosage

The gel is intended for external use. The drug is applied to the area of ​​inflammation or pain twice a day. The maximum daily dosage is 300 mg of gel. The duration of use depends on the degree of progression of the existing pathology.

Rules for using Fastum gel:

• when applying the drug to the skin, it is necessary to avoid getting the gel on open wounds (scratches, areas affected by dermatitis or dermatosis);
• Do not allow the medication to come into contact with the mucous membranes (severe irritation will occur);
• The gel is not intended for the manufacture of airtight dressings.

Video: "Stages of treatment for sports injuries"

Interaction with other pharmaceuticals

It is prohibited to use Fastum gel with other drugs from the NSAID group, diuretics and methotrexate-based medications. Concomitant use with warfarin increases the risk of serious bleeding.

Side effects

A negative reaction of the body to Fastum gel can manifest itself in the form of allergic rashes on the skin. From the central nervous system, side symptoms such as drowsiness or headache are possible (in rare cases, tinnitus or dizziness may occur). If you are intolerant to the drug, there is a risk of bronchospasm.

Overdose

The likelihood of an overdose of Fastum gel is minimal. External use prevents excessive accumulation of the active substance in the body. No episodes of severe cases of drug overdose have been recorded in medical practice. Long-term use of the medication may provoke the risk of an allergic reaction to ketoprofen.

Contraindications

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A contraindication for the use of Fastum gel is intolerance to the medication. It is prohibited to use the product if there is a history of allergic reactions to non-steroidal anti-inflammatory drugs.

With these factors, there is a risk of brochospasm in the patient.

The medication is not recommended for use during pregnancy and lactation. It is prohibited to use Fastum gel to treat children under twelve years of age.

Other contraindications:

• severe impairment of the functional state of the liver and kidneys;
• erosions and ulcers on the organs of the digestive system;
• wounds and abrasions on the skin;
• bronchial asthma and severe pathologies of the respiratory system;
• the presence of weeping eczema, dermatitis and dermatoses.

During pregnancy and lactation

It is not recommended to use Fastum Gel for pregnant women. The third trimester of gestation is especially prohibited. During lactation, the use of the drug is also not recommended. During treatment, breastfeeding is stopped.

special instructions

Impact on the ability to drive a car and operate machinery

When using Fastum Gel, you are allowed to drive a car and operate complex machinery. The exception is a high degree of pain or side effects such as dizziness.

Application in pediatric practice

Fastum gel can be used for children from twelve years of age. In younger age groups, ketoprofen can provoke unwanted reactions in the body.

For kidney problems

It is forbidden to use Fastum gel in cases of severe renal dysfunction.

The main active ingredient of the drug Fastum gel is ketoprofen, which is part of the group. This NSAID has the most pronounced analgesic effect. The external agent quickly relieves muscle tissue and exhibits analgesic activity. The deep penetration of ketoprofen occurs due to the properties of its molecules, which are characterized by small size and polarization. Maximum penetration is also ensured by a special gel base. Therefore, Fastum gel differs from other external agents from the NSAID group due to its most powerful anti-inflammatory and analgesic properties.

Composition and release forms

Fastum ointment is a transparent jelly-like substance with a pleasant smell, which is given to it by essential oils of lavender and neroli. Organic compounds function as flavoring agents and have a therapeutic effect. Essential oils contain biologically active substances (phytoncides, bioflavonoids) that improve microcirculation in tissues damaged by inflammation, replenishing the deficiency of molecular oxygen. Fastum gel contains the following auxiliary components:

• thickener carbomer 940;
• ethyl alcohol 96%;
• distilled water;
• neutralizing agent trolamine.

The active ingredient ketoprofen is found in the pharmacological preparation at a concentration of 2.5%. Auxiliary ingredients contribute to the rapid accumulation of the active substance in inflammatory foci and its uniform distribution. The external product is well absorbed and does not leave greasy marks on clothes and bedding. The manufacturer - the Italian company A.MENARINI INDUSTRIE FARMACEUTICHE RIUNITE - produces Fastum gel in aluminum tubes in 30 g, 50 g, 100 g packaging.

For long-term treatment of chronic joint pathologies, it is advisable to purchase the largest package of anti-inflammatory drugs. Its cost is approximately equal to the price of two small boxes of Fastum gel.

Secondary packaging of the drug is a cardboard box with attached instructions for use. The medicine should be stored at room temperature, away from direct sunlight. After opening the tube, the shelf life of the gel is significantly reduced.

pharmachologic effect

Fastum gel is characterized by analgesic, anti-exudative and anti-inflammatory activity, which is used for symptomatic therapy of ligaments and muscles. The effectiveness of the drug in relieving pathologies affecting ligaments, lymph nodes, tendons, muscles, blood vessels and skin has been clinically proven. The use of an anti-inflammatory drug to reduce the severity of joint syndrome leads to weakening at rest and during movement, a decrease in swelling and. The use of Fastum gel for bruises promotes rapid restoration of injured capillaries and veins, normalization of blood supply to damaged tissues with nutrients and biological substances.

In a randomized, double-blind study, it was found that the use of Fastum gel for a week in therapeutic dosages showed significantly better treatment results compared to placebo.

Pharmacodynamics

The evidence base for the analgesic and anti-inflammatory effects of ketoprofen has been accumulated after clinical trials on animals and volunteers. The active ingredient of Fastum gel, after penetration into the bloodstream and absorption into the tissue, begins to inhibit the synthesis of prostaglandins - the main mediators of swelling and inflammation. Platelet cyclooxygenase ceases to be produced, and the production of thromboxane 2 decreases.

The research results revealed the peculiarity of the anti-inflammatory activity of ketoprofen. The nonsteroidal drug inhibits prostaglandin synthesis much more effectively than other members of the NSAID group: Naproxen, Indomethacin, acetylsalicylic acid, Ibuprofen.

Since ketoprofen is a derivative of propionic acid in its chemical structure, it is characterized by the ability to accumulate in inflammatory foci in a higher concentration than in neighboring, undamaged tissues. The medical literature provides other evidence of the pronounced analgesic activity of Fastum gel, based on the pharmacokinetic actions of the main ingredient:

• inhibition of bradykinins;
• restoration of cell lysosome membranes.

Bradykinins- the most powerful endogenous substances that contribute to the occurrence of intense pain syndrome. One of the auxiliary components of the drug is highly concentrated ethanol. It not only forms and stabilizes the gel base of the ointment, but ensures maximum absorption of the active ingredient into the deepest tissues. Thanks to the complex effect of other auxiliary components, the main substance is absorbed by the dermis in the highest possible concentration. Triethanolamine creates a pH of the jelly-like mass corresponding to the acidity of human skin - 5.9.

Researchers are of particular interest in the systemic effect of nonsteroidal anti-inflammatory drugs for external use. Firstly, the use of this dosage form helps to significantly reduce the dose of NSAIDs for oral administration. Secondly, even when ketoprofen is applied to the affected tissues in large quantities (150 mg) after a few hours, its maximum concentration is detected in the systemic circulation- 0.08-0.15 mg/l. It can be concluded that Fastum gel maintains its therapeutic effectiveness for a long time without significant side effects.

The medical literature has not described cases of negative effects of ketoprofen on nephrons or hepatocytes. There have been isolated cases of the development of dyspeptic disorders: nausea, epigastric pain, diarrhea.

Pharmacokinetics

After using the drug Fastum Gel and the accumulation of the active ingredient in the inflammatory focus, its absorption into the systemic bloodstream begins. A non-steroidal drug is characterized by extremely low bioavailability - about 5%. Ketoprofen is not able to accumulate in tissues in concentrations hazardous to health. After binding to simple blood proteins albumin (90%), the active substance of the drug is metabolized in liver cells. Ketoprofen is utilized by hepatocytes during the chemical reaction of glucuronidation. Metabolites are excreted primarily by the kidneys, and only a small part of biologically inactive compounds leaves the body with feces in the composition of bile acids.

Transdermal absorption of the active ingredient and auxiliary components of Fastum gel is quite slow. However, this is not a disadvantage of the non-steroidal anti-inflammatory drug. The gradual absorption of ketoprofen ensures that the maximum therapeutic concentration remains in damaged tissues for a long time.

Fastum gel is not prescribed for sprains or sprains in pregnant and lactating women due to the ability of its active ingredient to easily pass through all histohematic barriers and distribute not only in tissues damaged by inflammation, but also in internal organs. Constant blood monitoring during treatment with the drug in patients with chronic renal failure is necessary, since if filtration and concentration of urine are impaired, the rate of excretion of ketoprofen decreases.

Indications for use

The widest range of applications of Fastum gel is the treatment of diseases of the musculoskeletal system. The greatest effectiveness of the drug is observed in the treatment of pathologies with acute or chronic processes that negatively affect the patient’s motor activity. A non-steroidal anti-inflammatory drug is used to reduce the severity of symptoms - pain and swelling. But it is also included in etiotropic treatment regimens due to its ability to prevent spread to neighboring healthy tissue areas. What does Fastum gel help with:

• osteochondrosis, parts of the spinal column;
• spondyloarthritis;
• lumbago;
• , including ;
• , joints;
• tenosynovitis;

A non-steroidal anti-inflammatory drug is used in traumatology to reduce the intensity of pain and relieve the inflammatory process in sprains, muscle and tendon damage. The drug has also proven itself well in the treatment of thrombophlebitis of superficial veins. After applying the ointment, blood circulation improves, which eliminates visible signs of venous insufficiency. Dermatologists include an external remedy in the therapeutic regimens of patients who have been diagnosed with inflammatory skin pathologies to reduce the intensity of painful sensations. Indications for the use of Fastum gel are diseases of the peripheral nervous system. The drug is recommended for neuralgia, pinched nerve roots.

Fastum gel is prescribed by surgeons, neurologists and rheumatologists to speed up recovery after operations. During the rehabilitation period, daily application of the product helps quickly recover damaged ligaments, tendons and soft tissues.

Instructions for use

To reduce the intensity of pain, squeeze out a 3-4 cm long column of the external agent from the tube. The amount of the drug may slightly depend on the area of ​​the affected articular, cartilage or soft tissues. For dermatitis, a higher dose may be required, but only after consulting with your doctor about the advisability and safety of such use of NSAIDs. The ointment is applied directly over the inflammatory focus and lightly rubbed in. The drug is gradually absorbed by the epidermis and penetrates into damaged areas of cartilage or joints.

The instructions for use of Fastum gel stipulate that the drug should not be applied more than 2 times a day due to the high probability of excessive accumulation of ketoprofen in the tissues. The duration of the course depends on the intensity of pain at a certain stage of the pathology, the general health of the patient and the presence of acute or chronic diseases of the liver and urinary organs. If treatment results have not been achieved within 2 weeks of using the gel, then it is replaced with an analogue or other methods of conservative therapy are used:

• physiotherapeutic procedures;
• oral administration of non-steroidal anti-inflammatory drugs.

With prolonged use of Fastum gel, it is possible to increase the sensitivity of the skin. Dermatologists recommend refraining from visiting a solarium and reducing the time spent in the open sun during treatment to prevent the manifestation of photosensitivity.

The drug is prescribed to patients for therapeutic manipulations of iontophoresis and phonophoresis. The purpose of these procedures is to ensure complete delivery of ketoprofen to tissues affected by inflammation. Since the ointment is characterized by low absorption into the systemic bloodstream, cases of overdose have not yet been described in the medical literature.

After rubbing a non-steroidal anti-inflammatory drug into the skin, you should wash your hands with any hygiene product. The essential oils of neroli and lavender included in the gel, and highly concentrated ethyl alcohol can cause pain and a burning sensation when they come into contact with the mucous membranes of the human body.

Contraindications

In dermatology, Fastum gel is not used in the treatment of pathologies if there are even minor open wound surfaces on the skin. Such diseases include eczema and weeping dermatitis. The use of NSAIDs is contraindicated in the presence of bacterial or fungal infectious agents in inflammatory lesions. In these cases, the external agent is prescribed to patients only after a course of antibacterial therapy. Absolute contraindications for Fastum Gel include the following conditions:

• individual sensitivity to the active ingredient or auxiliary components, the development of a systemic or local sensitization reaction - bronchospasm, contact dermatitis, urticaria, allergic rhinitis;
• intolerance to acetylsalicylic acid;
• hematopoietic disorders - leukopenia, thrombocytopenia;
• low blood clotting.

Fastum gel can be used with caution during pregnancy only in the first two trimesters. In later stages, a non-steroidal anti-inflammatory drug is not used, as with breastfeeding. Ages under 12 years are absolute contraindications for external use. The thick ointment is used under medical supervision if the patient has a history of pathologies of the digestive tract, which are characterized by difficult-to-heal ulcerations of the mucous membranes. During relapses of erosive gastritis, gastric and duodenal ulcers, ketoprofen ointment is not prescribed.

If Fastum gel is used to treat patients with liver and kidney diseases in the moderate or severe stages, then constant laboratory monitoring of blood and urine is carried out to identify possible negative changes in hematopoiesis.

A non-steroidal anti-inflammatory drug creates a maximum therapeutic concentration in the bloodstream. This determines the presence of a small number of side effects of the drug. An allergic reaction such as urticaria usually occurs when medical recommendations are not followed: single and daily dosages are exceeded, or the duration of the therapeutic course is exceeded.

Before applying Fastum gel locally to the site of inflammation, rub a small amount of the external agent into the crook of the elbow or wrist. If after 30-40 minutes no rashes or redness have formed on the skin, then the drug will not cause a sensitization reaction.

Comparative characteristics of analogues

Structural analogues of Fastum gel are not indicated in the instructions, but are easily identified by the active ingredient - ketoprofen. This non-steroidal anti-inflammatory drug is the active ingredient in the following drugs:

• Flamax;
• Febrofeed;
• Ketonal;
• Ketoprofen;
• Bystrumgel.

Analogues of Fastum gel in terms of therapeutic effects include all non-steroidal anti-inflammatory drugs for topical use: Piroxicam cream, Ibuprofen ointment, Meloxicam gel. The advantage of Fastum gel is a higher concentration of the active ingredient. In the pharmacy assortment there is only one drug with a high content of active ingredient - 5% Diclofenac gel. This concentration is also characterized by a significant number of side effects after the penetration of NSAIDs into the systemic circulation.

Ketoprofen was first synthesized in 1967, and at the same time comparative studies of the non-steroidal anti-inflammatory drug were carried out with drugs often prescribed at that time for the treatment of pathologies of the musculoskeletal system: Indomethacin, Ibuprofen and Phenylbutazone (not currently produced). During observation of patients, the great therapeutic effectiveness of ketoprofen was proven.

Fastum gel ointment is not considered cheap, but the high concentration of the active ingredient allows it to be used less frequently and in smaller quantities than other non-steroidal anti-inflammatory drugs. Here is the comparative cost of drugs from the NSAID group:

After some time, a publication by R.K. appeared in the press. Patel, which published the results of a comparative study of the therapeutic effects of three drugs from the group of non-steroidal anti-inflammatory drugs - ketoprofen, piroxicam and diclofenac. Among the participants in the experiment with acute inflammation in soft tissues, external NSAIDs were randomly distributed. When summing up, the indicators of pain with pressure and motor activity were taken into account. As a result of the experiment, the significant advantage of the gel with ketoprofen over other non-steroidal anti-inflammatory drugs was confirmed. Participants in the medical study also positively assessed the cooling effect of the external preparation.