Ceftriaxone-akos: description, treatment, price, reviews. Contraindications, side effects and overdose

"CEFTRIAXON": composition

The active substance is ceftriaxonum, which belongs to the class of third-generation cephalosporin antibiotics. These are the means that work against huge amount pathogenic bacteria, including those that produce β-lactamase, which destroys some antibiotics.

The drug is sold in the form of a powder for the manufacture of solutions for injections and infusions. Available in four dosage options - 250 mg, 500 mg, 1 and 2 grams per vial. It is not available in syrup or tablet form.

How does it affect the body? (Pharmacodynamics)

In humans, ceftriaxone has a bactericidal effect. It makes it impossible to synthesize the substance - murein, from which the bacterial wall is made. Myrein is a base laced with short protein chains. Thanks to him, the bacterium exists. If you block its synthesis, then new bacterial ones are not formed, and existing ones are destroyed.

Ceftriaxone acts on a huge number of rods, cocci, both gram-positive and gram-negative. It is not effective against:

• staphylococci resistant to methicillin;
• group D streptococci;
• enterococci.

The antibiotic penetrates into all body fluids: plasma, cerebrospinal fluid, bile, urine.

Injections "CEFTRIAXON" - what helps?

Almost a doctor of any specialization, faced with a severe bacterial process, can prescribe ceftriaxone injections. What helps? It is used to treat diseases caused by bacteria sensitive to the drug:

• purulent infections abdominal cavity including peritonitis, gallbladder empyema;
• upper and lower respiratory tract, including pleural empyema, lung abscess;
• pyelonephritis, urethritis, prostatitis, cystitis;
• typhoid fever;
• syphilis;
• sepsis, endocarditis;
• purulent wounds, complications burn lesions skin and mucous membranes;
• ENT diseases;
• salmonellosis;
• gonorrhea;
• tick-borne borreliosis.

It should not be used in patients allergic to antibiotics of the cephalosporin class. The drug is prescribed very carefully:

• with renal and / or hepatic insufficiency of 2 - 3 degrees;
• premature babies;
• people who have undergone erosive and ulcerative or inflammatory diseases intestines;
• at high content serum bilirubin in newborns.

When prescribing to pregnant women, it is necessary to correlate the benefit to the mother from the treatment and the potential harm to the child from the medicine. Breastfeeding receiving ceftriaxone is recommended to transfer the baby to artificial feeding.

During clinical trials less than 5% of patients experienced any adverse reactions:

• manifestations of allergies;
• nausea, vomiting, diarrhea;
• changes in the number of blood cells;
• headaches and dizziness.

The symptoms are so general that it is not worth talking about serious adverse reactions. Ceftriaxone is prescribed for extremely severe bacterial lesions internal organs. It is impossible to determine whether nausea is caused by a drug or increasing intoxication, against the background of the death of a huge number of bacterial cells. The main drug used to treat syphilis is penicillin, its later types. Ceftriaxone refers in this case to second-line antibiotics: it is prescribed for allergies to penicillin, pregnant women, and other groups of patients in whom penicillins cannot be used. A huge plus of the drug is activity not only in the primary, but also in the secondary, tertiary form of syphilis. It even cures syphilitic lesions nervous system. In addition, the drug can be used both during stationary

"CEFTRIAXONE": instructions for use (injections) - how to breed?

Powder for solution for intramuscular or intravenous administration bred:

• lidocaine (only for i / m administration!);
• water for injection (injections into the muscle with water are more painful than with an anesthetic);
• physiological solution.

How to dilute ceftriaxone in the instructions for the use of injections is detailed

How to take?

The duration of the course, dosage, determined by the doctor. You can administer the medicine once or twice a day. The maximum dose for an adult is 4 grams per day, for a child - 2 grams per day. Treatment lasts until the doctor is sure that the infection is defeated. There are diseases in which the medicine is administered once, there are those in which it is necessary to repeat injections up to 14 days.

How to breed and with what?

Dilute the powder:

• 2% lidocaine solution, which is sold in a pharmacy, one ampoule per bottle, regardless of dosage;
• water for injection on the same principle as lidocaine, but for intravenous injection it is better to take 5 - 10 ml of water, for i / m - 2-3 ml (painful injection);
• saline for intravenous infusion: a little solution is poured into a vial, shaken, drawn into a syringe, added to the vial with the remaining liquid. Total solution for one infusion 40 - 100 ml. Instead of saline, you can use glucose with insulin, dextrose.

Do not dilute the powder with a liquid containing calcium.

"CEFTRIAXONE": injection price 1.0 (price in pharmacies)

In different pharmacies, the cost of the drug may be different, which is explained not only by belonging to different pharmaceutical chains, but also by the manufacturer, sales region, etc. Medium c ena ceftriaxone the price of injections 1.0 is about 25 rubles:

1. WER.RU - 23 rubles;
2. Europharm - 23 rubles;
3. Dialogue - 26 rubles;
4. IFC Pharmacy - 29 rubles;
5. Maxavit - 15 rubles;
6. Pharmacy - 22 rubles.

"CEFTRIAXON": analogues

The medicine is produced by several Russian pharmaceutical companies: Biochemist Saransk, Sintez AKOMP, Ruzpharma, Protek SVM, etc. The cost of 1 gram differs by 1-2 rubles. Imported substitute you can buy from 218 to 600 rubles per 1 gram.

Ceftriaxone: analogues in tablets

The tablets contain 3rd generation cephalosporins, with a different active ingredient. As a substitute for ceftriaxone, analogues in tablets can be:

	Suprax Solutab- Italian drug active ingredient- cefixime, produced in tablet form. It is prescribed for the treatment of infectious and inflammatory diseases. Price - 833 rubles.
	panzef- tablets of the Macedonian pharmaceutical company Alkaloid AD based on cefixime. Prescribed for the treatment of infections urinary tract, otitis, pharyngitis, bronchitis, gonorrhea, etc. Price - 528 rubles.

Previous generations of cephalosporins are also made in tablets.

"CEFTRIAXONE": analogues in injections

Medicines in which ceftriaxone is the active substance are released only for injection. Of the affordable analogues of ceftriaxone in injections, one can consider:

	Rocefin- a French-Swiss drug. operates on the basis of the same active substance. It has an antibacterial, bactericidal effect on the body. Price - from 49.60 rubles per 1 g.
	Medakson- Cypriot broad-spectrum antibiotic. It is used to combat infectious diseases of various etymologies. Price - from 171 rubles.
	Cefazolin – domestic antibiotic class of cephalosporins from the first generation. With a similar spectrum of activity, a list of diseases for which they are prescribed, cefazolin has more side effects and is worse tolerated by patients. Price - from 37.50 rubles per 1 g.

Important! The choice between these drugs should be made only by a doctor: you can not use more modern facility against flora, which is perfectly treated by the first generation. This will lead to the development of resistance in bacteria to antibiotics.

"CEFTRIAXON": reviews

Ceftriaxone saved my life: banal appendicitis due to negligence own health ended in purulent peritonitis. For a week in the intensive care unit, they put a dropper with ceftriaxone. I was sick, not sick - I don’t remember, it was so bad. The doctor said that I was very lucky that there are already such powerful antibiotics.

I fell ill with a terrible sinusitis: my head is splitting, the temperature is 40, I won’t even talk about the color of what flowed from the nose. The doctor prescribed ceftriaxone in injections. Husband made at home. The first one was done on water for injection, but it turned out to be very painful. Then they put only with lidocaine. Treated for 5 days. This nightmare never happened again.

Doctor's review:

Nikiforov Ivan Andreevich, 52 years old

If you have not yet taken Ceftriaxone-AKOS, or are just thinking about it, go to the doctor's office in the hospital, he will be able to give you advice about this.

What form is the drug in?

cooking powder injection solution 0.5g

powder for solution intramuscular injection 500mg

lyophilized powder for injection solution 0.5g

Who makes the medicine

Synthesis of ACO

Kurgan (Russia)

Pharm. Group

Third generation cephalosporins

Ingredients (what is it made of)

The active substance is ceftriaxone.

International (international) name

Ceftriaxone

Synonyms (analogues)

Azaran, Axone, Betasporina, Biotraxone, Ificef, Lendacin, Lifaxon, Longacef, Megion, Medaxon, Movigip, Novosef, Oframax, Roceferin, Rocephin, Stericef, Torocef, Troxon, Forcef, Cefaxone, Cefathrin, Cefathrin sterile, Cefogram, Cefson, Ceftriabol , Ceftriaxone, Ceftriaxone "Biochemi", Ceftriaxone Danson, Ceftriaxone Kabi, Ceftriaxone sodium, Ceftriaxone Protech, Ceftriaxone Elfa, Ceftriaxone-Alpa, Ceftriaxone-Vial, Ceftriaxone-Darnitsa, Ceftriaxone-Jodas, Ceftriaxone-KMP, Ceftriaxone-Promed, Ceftriaxone sodium salt, Ceftriaxone sodium salt sterile, Ceftrifin, Ceftron

pharmachologic effect

Antibacterial (bacteriostatic). It inhibits transpeptidase, disrupts the biosynthesis of the mucopeptide of the bacterial cell wall. Destroyed under the influence gastric juice(does not apply internally). After intramuscular administration, it is rapidly and completely absorbed. The maximum concentration at a dose of 1 g ( intravenous infusion within 30 minutes) is 100-150 mg/l, after intramuscular injection- 80 mg/l after 2-3 hours. Within 4 days, a stable concentration in the blood is achieved. Easily penetrates into organs, fluids and bone tissue. The half-life is 5.8-8.7 hours (at doses of 0.15-3g). It is excreted unchanged by the kidneys (50-65%) within 48 hours, the rest - with bile. It has wide range actions: active against aerobic gram-positive ( Staphylococcus aureus, incl. producing penicillinase Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Streptococcus bovis) and Gram-negative (Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Acinetobacter calcoaceticus, Haemophilus influenzae, including penicillinase-producing strains, Haemophilus parainfluenzae, Kellasibella pneumoniae, Kellasibella pneumoniae, Kellasito pneumoniae morganii, Neisseria meningitidis, Neisseria gonorrhoeae, including penicillin-producing strains, Proteus mirabilis, Proteus vulgaris, Serratia marcescens, many strains of Pseudomonas aeruginosa, Citrobacter spp., Salmonella spp., Providencia spp., Shigella spp., Serratia spp., Treponema pallidum) microorganisms, anaerobes (Bacteroides fragilis, Clostridium spp., Peptostreptococcus species, Peptococcus spp., Bacteroides bivius, Bacteroides melaninogenicus). May act on multi-resistant strains that are tolerant to penicillins and first-generation cephalosporins and aminoglycosides.

When is it appropriate to use

Upper and lower respiratory tract infections (acute and Chronical bronchitis, lung abscess, pneumonia, pleural empyema), ear, throat and nose, skin and soft tissues, urinary organs(sharp and chronic pyelonephritis, pyelitis, cystitis, epididymitis, prostatitis, etc.), joints, wounds, maxillofacial area, abdominal organs (peritonitis, biliary tract and gastrointestinal tract), uncomplicated gonorrhea, sepsis and bacterial septicemia, osteomyelitis, bacterial meningitis and endocarditis, chancroid and syphilis, Lyme disease (spirochetosis), typhoid fever, salmonellosis and salmonella carriers, infections in immunocompromised patients, prevention of postoperative infectious complications.

When not to use

hypersensitivity, hepatic-renal insufficiency, bleeding and diseases of the gastrointestinal tract in history, especially non-specific ulcerative colitis, enteritis or colitis associated with the use antibacterial drugs; pregnancy and lactation.

Possible side effects

Nausea, vomiting, constipation, abdominal pain, flatulence, diarrhea, taste disturbance, stomatitis, glossitis, pseudomembranous colitis, transient increase in transaminase activity, cholestatic jaundice, increased creatinine, glucosuria, casts in the urine, hematuria, oliguria, anuria, thrombocytosis, thrombocytopenia, leukopenia, rarely - hemolytic anemia, neutropenia, lymphopenia, decreased plasma factors blood clotting, prolongation of prothrombin time, headache, dizziness, nose bleed, dysbacteriosis, superinfection, candidiasis, allergic reactions(rash, pruritus, urticaria), fever or chills, serum sickness, bronchospasm, eosinophilia, multiforme exudative erythema, Stevens-Johnson syndrome and anaphylactic shock; local reactions: pain or infiltration at the injection site, rarely - thrombophlebitis after intravenous administration.

Interaction

Enhances (mutually) the effect of aminoglycosides against many gram-negative microorganisms. NSAIDs and other inhibitors of platelet aggregation increase the likelihood of bleeding, loop diuretics and nephrotoxic drugs - impaired renal function. Pharmaceutically incompatible with other antimicrobial agents.

Application method

Intramuscularly and intravenously; adults and children over 12 years old 1-2 g 1 time per day, if necessary - up to 4 g (preferably in 2 injections every 12 hours). The duration of treatment depends on the type of infection and the severity of the condition. After the disappearance of symptoms and normalization of temperature, it is recommended to continue the application for at least three days. In uncomplicated gonorrhea, 0.25 g is administered intramuscularly once. For newborns up to 2 weeks, the daily dose is 20-50 mg / kg, for children from 3 weeks to 12 years - 50-80 mg / kg per day, in 2 injections. Daily dose should not exceed 2 g, in premature babies - 50 mg / kg, prevention of postoperative infections - 1 g once 1/2 - 2 hours before surgery. Intravenously as an infusion over 15-30 minutes at a concentration of 10-40 mg / ml. For intravenous bolus injection, the drug is dissolved in sterile water for injection in a ratio of 1:10, for intramuscular injection - in a 1% solution of lidocaine (0.5 g of powder in 2 ml or 1 g in 3.5 ml).

Exceeding the norm

Treatment: symptomatic therapy.

Use with caution in newborns with hyperbilirubinemia, premature babies. When long-term use possible development of dysbacteriosis. Dose adjustment and monitoring of plasma concentrations is required in patients on hemodialysis and in combination with renal and hepatic insufficiency. At arterial hypertension and violation of the water-electrolyte balance, it is necessary to check the level of sodium in the plasma.

Storage method

List B. Store at room temperature in a cool dry place.

From this medical article you can see drug Ceftriaxone. The instructions for use will explain in which cases injections can be used, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Ceftriaxone, from which you can find out whether the antibiotic helped in the treatment of infections in adults and children. The instructions list Ceftriaxone analogues, drug prices in pharmacies, as well as its use during pregnancy.

Ceftriaxone is a 3rd generation cephalosporin antibiotic. It has a broad bactericidal action and is active against aerobic and anaerobic gram-negative and gram-positive microorganisms. The drug is intended for parenteral use only.

Composition and form of release

Ceftriaxone is produced in the form of a powder for preparing a solution in glass vials of 0.5, 1 or 2 g containing the same name. active substance- in the amount of 0.5 g, 1 or 2 g.

Pharmacological properties

Instructions for use informs that Ceftriaxone is a semi-synthetic antibiotic belonging to the group of cephalosporins of the 3rd generation. Its bactericidal activity is provided by suppressing the synthesis of cell membranes.

This drug is resistant to the action of beta-lactamase. Means shows wide bactericidal action. It is active against aerobic gram-negative and gram-positive microorganisms, as well as anaerobic microorganisms.

After i / m administration, Ceftriaxone is rapidly and completely absorbed into the systemic circulation. Penetrates well into tissues liquid media body: respiratory tract, bones, joints, urinary tract, skin, subcutaneous tissue and abdominal organs. With inflammation of the meningeal membranes, it penetrates well into the cerebrospinal fluid.

What helps ceftriaxone?

According to the instructions, the drug is prescribed for infectious and inflammatory diseases:

• ear, throat, nose;
• sepsis;
• gonorrhea;
• skin and soft tissues;
• genital organs;
• disseminated Lyme borreliosis in the early and late stages;
• respiratory tract;
• meningitis;
• urinary tract and kidneys;
• abdominal organs (infections of the biliary tract and gastrointestinal tract, peritonitis);
• joints and bones;
• in immunocompromised patients;
• pelvic organs;
• wound infections.

Why is Ceftriaxone still prescribed? The indication for the appointment is the prevention of infections after operations.

Instructions for use

Ceftriaxone is administered intramuscularly and intravenously (by jet or drip).

For adults and children over 12 years old, the dose is 1-2 g 1 time per day or 0.5-1 g every 12 hours. The maximum daily dose is 4 g.

For infants and children under 12 years of age, the daily dose is 20-80 mg / kg. In children weighing 50 kg or more, adult doses are used.

For the prevention of postoperative infectious complications, it is administered once at a dose of 1-2 g (depending on the degree of risk of infection) 30-90 minutes before the start of the operation. For operations on the colon and rectum, it is recommended additional introduction drug from the group of 5-nitroimidazoles.

In patients with impaired renal function, dose adjustment is required only if kidney failure severe (CC less than 10 ml / min), in this case, the daily dose of ceftriaxone should not exceed 2 g.

Ceftriaxone for children with infections of the skin and soft tissues is prescribed in a daily dose of 50-75 mg / kg of body weight 1 time / day or 25-37.5 mg / kg every 12 hours, but not more than 2 g per day. In severe infections of other localization - at a dose of 25-37.5 mg / kg every 12 hours, but not more than 2 g per day.

A dose greater than 50 mg/kg body weight should be given as an IV infusion over 30 minutes. The duration of the course of treatment depends on the nature and severity of the disease.

For the treatment of gonorrhea, the dose is 250 mg IM, once.

For newborns (up to the age of 2 weeks), the dose is 20-50 mg / kg per day.

For bacterial meningitis in infants and children younger age the dose is 100 mg / kg 1 time per day. The maximum daily dose is 4 g. The duration of therapy depends on the type of pathogen and can range from 4 days for meningitis caused by Neisseria meningitidis to 10-14 days for meningitis caused by susceptible strains of Enterobacteriaceae.

With otitis media, the drug is administered intramuscularly at a dose of 50 mg/kg of body weight, but not more than 1 g.

Rules for the preparation and administration of injection solutions (how to dilute the drug)

• Injection solutions should be prepared immediately before use.
• To prepare a solution for intramuscular injections, 500 mg of the drug is dissolved in 2 ml, and 1 g of the drug in 3.5 ml of a 1% lidocaine solution. It is recommended to inject no more than 1 g into one gluteal muscle.
• Dilution for intramuscular use can also be carried out using water for injection. The effect is the same, only there will be a more painful introduction.
• To prepare a solution for intravenous injection, 500 mg of the drug is dissolved in 5 ml, and 1 g of the drug in 10 ml of sterile water for injection. The injection solution is administered intravenously slowly over 2-4 minutes.
• To prepare a solution for intravenous infusion, 2 g of the drug is dissolved in 40 ml of one of the following solutions that do not contain calcium: 0.9% sodium chloride solution, 5-10% dextrose (glucose) solution, 5% levulose solution. The drug at a dose of 50 mg/kg or more should be administered intravenously over 30 minutes.
• Freshly prepared solutions of ceftriaxone are physically and chemically stable for 6 hours at room temperature.

Read also this article: Tablets, Codelac syrup: instructions, price and reviews

Contraindications

According to the instructions, Ceftriaxone is not prescribed for known hypersensitivity to cephalosporin antibiotics or auxiliary components of the drug.

Relative contraindications:

• the neonatal period if the child has hyperbilirubinemia;
• prematurity;
• kidney or liver failure;
• lactation;
• pregnancy;
• enteritis, UC or colitis associated with the use of antibacterial agents.

Side effect

The drug may cause a number adverse reactions body:

• anaphylactic shock;
• hypercreatininemia;
• flatulence;
• stomatitis, glossitis;
• taste disorder;
• dysbacteriosis;
• oliguria, impaired renal function;
• abdominal pain;
• diarrhea;
• increased urea content;
• glycosuria;
• nosebleeds;
• urticaria, rash, itching;
• nausea, vomiting;
• hematuria;
• bronchospasm;
• headache, dizziness;
• anemia, leukopenia, leukocytosis, lymphopenia, neutropenia, granulocytopenia, thrombocytopenia.

During pregnancy and breastfeeding

The drug is contraindicated in the first trimester of pregnancy. If necessary, the appointment of a nursing woman, the child should be transferred to the mixture.

Clinical and pharmacological group

• Not specified. See instructions

Pharmacological action

Pharmacological group

• Cephalosporins

Powder for the preparation of an injection solution for intravenous administration of Ceftriaxone-AKOS (Ceftriaxone-AKOS)

Instructions for medical use drug

Indications for use

Peritonitis, sepsis, meningitis; infections of the abdominal organs (peritonitis, inflammatory diseases of the gastrointestinal tract, biliary tract, including cholangitis, gallbladder empyema), diseases of the upper and lower respiratory tract (including pneumonia, lung abscess, pleural empyema), bone infections , joints, skin and soft tissues, urogenital area (including gonorrhea, pyelonephritis); infected wounds, burns; prevention of postoperative infection, infectious diseases in immunocompromised persons.

Release form

powder for the preparation of an injection solution for intravenous administration 0.5 g; bottle (bottle) 10 ml carton pack 1;

powder for the preparation of an injection solution for intravenous administration 1 g; bottle (bottle) 10 ml carton pack 1;

powder for the preparation of an injection solution for intravenous administration 1 g; vial (bottle) 10 ml carton pack 10;

powder for the preparation of an injection solution for intravenous administration 2 g; vial (vial) 10 ml carton pack 5;

powder for the preparation of an injection solution for intravenous administration 0.5 g; bottle (bottle) 20 ml carton pack 10;

powder for the preparation of an injection solution for intravenous administration 2 g; vial (bottle) 10 ml carton pack 10;

powder for the preparation of an injection solution for intravenous administration 0.5 g; bottle (bottle) 10 ml box (box) 50;

powder for the preparation of an injection solution for intravenous administration 1 g; bottle (bottle) 10 ml box (box) 50;

powder for the preparation of an injection solution for intravenous administration 2 g; bottle (bottle) 10 ml carton pack 1;

Composition and form of release
Powder for solution for intravenous and intramuscular administration 1 vial.
ceftriaxone 0.5 g 1 g 2 g

Powder for the preparation of an injection solution for intravenous administration 1 vial.
ceftriaxone 0.5 g 1 g 2 g
in vials of 10 ml; without a carton pack or in a carton pack of 10 bottles, or in a box of 50 bottles.

Solution for injection for intramuscular injection 1 vial.
ceftriaxone 0.5 g 1 g 2 g
in vials of 10 ml; in a carton pack of 1 or 10 bottles, or in a box of 50 bottles.

Pharmacodynamics

Active against: gram-positive aerobes - Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Streptococcus bovis; gram-negative aerobes - Aeromonas spp., Alcaligenes spp., Branhamella catarrhalis (forming and non-forming beta-lactamase), Citrobacter spp., Enterobacter spp. (some strains are resistant), Escherichia coli, Haemophilus ducreyi, Haemophilus influenzae (including penicillinase-producing strains), Haemophilus parainfluenzae, Klebsiella spp., (including Klebsiella pneumoniae), Moraxella spp., Morganella morganii, Neisseria gonorrhoeae (including strains producing penicillinase), Neisseria meningitidis, Plesiomonas shigelloides, Proteus mirabilis, Proteus vulgaris, Providencia spp., Salmonella spp. (including Salmonella typhi), Serratia spp. (including Serratia marcescens), Shigella spp., Vibrio spp. (including Vibrio cholerae), Yersinia spp. (including Yersinia enterocolitica).

Individual strains of Pseudomonas aeruginosa are also sensitive; anaerobes: Bacteroides spp. (including strains of Bacteroides fragilis), Clostridium spp. (except Clostridium difficile), Fusobacterium spp. (except Fusobacterium varium, Fusobacterium mortiferum), Peptococcus spp., Peptostreptococcus spp., as well as Treponema pallidum, Borrelia burgdorferi.

Resistant strains of Staphylococcus spp., showing resistance to methicillin, strains of Enterococcus spp., Bacteroides spp.

Pharmacokinetics

When administered parenterally, it penetrates well into tissues and body fluids. Bioavailability with intramuscular injection is 100%, the time to reach Cmax with intramuscular injection is 2-3 hours. In case of inflammation of the meningeal membranes, it penetrates well into the cerebrospinal fluid.

Cmax when administered intravenously at a dose of 50 mg / kg in plasma is 216 μg / ml, in cerebrospinal fluid - 5.6 μg / ml. In adults, 2-24 hours after administration at a dose of 50 mg / kg, the concentration in the cerebrospinal fluid is many times higher than the minimum inhibitory concentrations for the most common pathogens of meningitis. Protein binding - 85%, T1 / 2 - 5.8–8.7 h, volume of distribution - 5.78–13.5 l, plasma Cl - 0.58–1.45 l / h, renal - 0, 32–0.73 l/h.

In newborns up to 8 days and in the elderly over 75 years, T1 / 2 increases ~ 2 times. In adults, 50-60% is excreted in active form with urine within 48 hours. In renal failure, the excretion slows down. From 30 to 50% of the drug is excreted in the bile. Under influence intestinal flora converted to an inactive metabolite. In neonates, ~70% of the administered dose is excreted by the kidneys.

Use during pregnancy

Contraindicated in the first trimester of pregnancy. At the time of treatment should stop breastfeeding.

Contraindications for use

Hypersensitivity (including to penicillins), pregnancy (1 trimester).

Side effects

From the nervous system and sensory organs: headache, dizziness.

From the side of cardio-vascular system and blood (blood formation, hemostasis): leukopenia, neutropenia, granulocytopenia, thrombocytopenia, hemolytic anemia.

From the digestive tract: nausea, vomiting, stomatitis, glossitis, diarrhea, cholestasis, pseudomembranous enterocolitis, increased activity of hepatic transaminases.

Allergic reactions: about 1% - urticaria, fever, eosinophilia, rash, itching, urticaria, exanthema, allergic dermatitis, exudative erythema multiforme, edema, anaphylactic shock.

Others: oliguria, hypocoagulation, chills; hyperazotemia, hypercreatininemia, increased urea content; candidomycosis and other superinfections; with a / in the introduction - phlebitis, pain along the vein; when i / m - soreness at the injection site.

Dosage and administration

V / m (deep into the gluteal muscle) or / in (drip for 30 minutes or jet, injected slowly over 2-4 minutes). For i / m administration, 1 g is dissolved in 3.5 ml of a 1% lidocaine solution. For intravenous administration, the contents of 1 vial are diluted in 10 ml of water for injection. For intravenous infusion, dissolve 2 g in 40 ml of 0.9% sodium chloride solution, 0.45% sodium chloride solution containing 2.5% glucose, 5% glucose solution, 10% glucose solution, 5% fructose solution or 6% dextran solution.

Adults and children over 12 years old (weighing more than 50 kg) - 1-2 g 1 time per day, in severe cases or in cases of infections caused by moderately susceptible pathogenic microorganisms, the daily dose is increased to 4 g (divided into 2 injections). Newborns (up to 2 weeks) - 20-50 mg / kg / day, infants and children under 12 years old - 20-80 mg / kg / day.

Doses of 50 mg/kg or more should be administered as an IV infusion over 30 minutes. The duration of treatment depends on the nature of the disease.

For bacterial meningitis in infants and young children, the initial dose is 0.1 g / kg 1 time per day ( maximum dose- 4 g). The duration of treatment depends on the pathogen and can range from 4 days for Neisseria meningitidis to 10-14 days for susceptible strains of pathogens of the Enterobacteriaceae family.

Prevention of infectious diseases in pre- and postoperative period- 30-90 minutes before the start of the operation - 1-2 g (often intravenously).

In the treatment of gonorrhea - in / m 0.25 g once.

In renal failure (Cl creatinine less than 10 ml / min), the daily dose is not more than 2 g (in case of impaired renal and / or liver function, as well as in patients on hemodialysis, it is necessary to control the concentration of ceftriaxone in the blood plasma, because the speed of its removal decreases).

Interactions with other drugs

There is synergy antibacterial action when administered concomitantly with aminoglycoside antibiotics. Pharmaceutically incompatible with solutions of other antibiotics. When used with aminoglycosides, it enhances (mutually) activity against many gram-negative bacteria.

Precautions for use

With caution - hyperbilirubinemia (in newborns and premature babies), ulcerative colitis.

With simultaneous renal and hepatic insufficiency, in patients on hemodialysis, plasma concentrations should be regularly determined. At long-term treatment it is necessary to regularly monitor the picture of peripheral blood, indicators functional state liver and kidneys.

In rare cases, ultrasound of the gallbladder shows a blackout that disappears after discontinuation of the drug (even if this phenomenon is accompanied by pain in the right hypochondrium, it is necessary to continue antibiotic treatment and prescribe symptomatic therapy)

Special instructions for admission

Freshly prepared solutions are stable for 6 hours at room temperature.

Storage conditions

List B.: In a dry, dark place, at a temperature of 15–25 ° C. The prepared solution is suitable for use for 6 hours at a temperature of 5 to 25 °C and 24 hours at a temperature of 2 to 5 °C.

Are you interested in Ceftriaxone-AKOS? Do you want to know more detailed information Or do you need to see a doctor? Or do you need an inspection? You can book an appointment with a doctor– clinic Eurolaboratory always at your service! The best doctors examine you, advise, provide needed help and make a diagnosis. you also can call a doctor at home. Clinic Eurolaboratory open for you around the clock.

** Attention! The information provided in this drug formulary is intended to medical specialists and should not be the basis for self-medication. The description of the drug Ceftriaxone-AKOS is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need specialist advice!

Treatment with Ceftriaxone-AKOS should be agreed with the doctor who is treating you.

Release form

powder for injection solution 0.5g

powder for solution for intramuscular injection 500 mg

lyophilized powder for injection solution 0.5g

Manufacturers

Synthesis of ACO

Kurgan (Russia)

Group

Third generation cephalosporins

The composition of the drug

The active substance is ceftriaxone.

International non-proprietary name

Ceftriaxone

Similar drugs

Azaran, Axone, Betasporina, Biotraxone, Ificef, Lendacin, Lifaxon, Longacef, Megion, Medaxon, Movigip, Novosef, Oframax, Roceferin, Rocephin, Stericef, Torocef, Troxon, Forcef, Cefaxone, Cefathrin, Cefathrin sterile, Cefogram, Cefson, Ceftriabol , Ceftriaxone, Ceftriaxone "Biochemi", Ceftriaxone Danson, Ceftriaxone Kabi, Ceftriaxone Sodium, Ceftriaxone Protech, Ceftriaxone Elfa, Ceftriaxone-Alpa, Ceftriaxone-Vial, Ceftriaxone-Darnitsa, Ceftriaxone-Jodas, Ceftriaxone-KMP, Ceftriaxone-Na , Ceftriaxone sodium salt sterile, Ceftrifin, Ceftron

pharmachologic effect

Antibacterial (bacteriostatic). It inhibits transpeptidase, disrupts the biosynthesis of the mucopeptide of the bacterial cell wall. Destroyed by the action of gastric juice (not applied orally). After intramuscular administration, it is rapidly and completely absorbed. The maximum concentration at a dose of 1 g (intravenous infusion over 30 minutes) is 100-150 mg / l, after intramuscular injection - 80 mg / l after 2-3 hours. Within 4 days, a stable concentration in the blood is achieved. Easily penetrates into organs, fluids and bone tissue. The half-life is 5.8-8.7 hours (at doses of 0.15-3g). It is excreted unchanged by the kidneys (50-65%) within 48 hours, the rest - with bile. It has a wide spectrum of action: it is active against aerobic gram-positive (Staphylococcus aureus, including those producing penicillinase, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus viridans, Streptococcus bovis) and gram-negative (Enterobacter aerogenes, Enterobacter cloacae, Esche coli, Acinetobacter calcoaceticus, Haemophilus influenzae, including penicillinase-producing strains, Haemophilus parainfluenzae, Klebsiella oxytoca, Klebsiella pneumoniae, Morganella morganii, Neisseria meningitidis, Neisseria gonorrhoeae, including penicillin-forming strains, Proteus mirabilis, Proteus vulgaris, Serratia many strains of Pseudomonas aeruginosa, Citrobacter spp., Salmonella spp., Providencia spp., Shigella spp., Serratia spp., Treponema pallidum) microorganisms, anaerobes (Bacteroides fragilis, Clostridium spp., Peptostreptococcus species, Peptococcus spp., Bacteroides bivius, Bacteroides melanino genicus). May act on multi-resistant strains that are tolerant to penicillins and first-generation cephalosporins and aminoglycosides.

Indications for use

Infections of the upper and lower respiratory tract (acute and chronic bronchitis, lung abscess, pneumonia, pleural empyema), ear, throat and nose, skin and soft tissues, urinary organs (acute and chronic pyelonephritis, pyelitis, cystitis, epididymitis, prostatitis, etc.). ), joints, wounds, maxillofacial region, abdominal organs (peritonitis, biliary tract and gastrointestinal tract), uncomplicated gonorrhea, sepsis and bacterial septicemia, osteomyelitis, bacterial meningitis and endocarditis, chancre and syphilis, Lyme disease (spirochetosis), typhoid fever, salmonellosis and salmonellosis, infections in immunocompromised patients, prevention of postoperative infectious complications.

Contraindications for use

Hypersensitivity, hepatic and renal insufficiency, bleeding and diseases of the gastrointestinal tract in history, especially ulcerative colitis, enteritis or colitis associated with the use of antibacterial drugs; pregnancy and lactation.

Possible side effects

Nausea, vomiting, constipation, abdominal pain, flatulence, diarrhea, taste disturbance, stomatitis, glossitis, pseudomembranous colitis, transient increase in transaminase activity, cholestatic jaundice, increased creatinine, glucosuria, casts in the urine, hematuria, oliguria, anuria, thrombocytosis, thrombocytopenia, leukopenia, rarely - hemolytic anemia, neutropenia, lymphopenia, decreased levels of plasma coagulation factors, prolongation of prothrombin time, headache, dizziness, epistaxis, dysbacteriosis, superinfection, candidiasis, allergic reactions (rash, itching, urticaria), fever or chills, serum sickness, bronchospasm, eosinophilia, erythema multiforme exudative, Stevens-Johnson syndrome and anaphylactic shock; local reactions: pain or infiltration at the injection site, rarely - thrombophlebitis after intravenous administration.

Interaction

Enhances (mutually) the effect of aminoglycosides against many gram-negative microorganisms. NSAIDs and other inhibitors of platelet aggregation increase the likelihood of bleeding, loop diuretics and nephrotoxic drugs - impaired renal function. Pharmaceutically incompatible with other antimicrobial agents.

Mode of application

Intramuscularly and intravenously; adults and children over 12 years old 1-2 g 1 time per day, if necessary - up to 4 g (preferably in 2 injections every 12 hours). The duration of treatment depends on the type of infection and the severity of the condition. After the disappearance of symptoms and normalization of temperature, it is recommended to continue the application for at least three days. In uncomplicated gonorrhea, 0.25 g is administered intramuscularly once. For newborns up to 2 weeks, the daily dose is 20-50 mg / kg, for children from 3 weeks to 12 years - 50-80 mg / kg per day, in 2 injections. The daily dose should not exceed 2 g, in premature babies - 50 mg / kg, prevention of postoperative infections - 1 g once 1/2 - 2 hours before surgery. Intravenously as an infusion over 15-30 minutes at a concentration of 10-40 mg / ml. For intravenous bolus injection, the drug is dissolved in sterile water for injection in a ratio of 1:10, for intramuscular injection - in a 1% solution of lidocaine (0.5 g of powder in 2 ml or 1 g in 3.5 ml).

Exceeding the dose of the drug

Treatment: symptomatic therapy.

Directions

Use with caution in newborns with hyperbilirubinemia, premature babies. In the case of prolonged use, the development of dysbacteriosis is possible. Dose adjustment and monitoring of plasma concentrations is required in patients on hemodialysis and in combination with renal and hepatic insufficiency. With arterial hypertension and a violation of the water and electrolyte balance, it is necessary to check the level of sodium in the plasma.

How to store

List B. Store at room temperature in a cool dry place.

Vacation method

Released by prescription

Pay Special attention! The above information is for physicians only!