Medicinal reference book geotar. The ability to influence the reaction rate when driving vehicles or other mechanisms

Active substanceSodium lactate solution complex [Potassium chloride + Calcium chloride + Sodium chloride + Sodium lactate]

Sodium lactate - 3.20 g

Excipients:Water for injections - up to 1.0 l

Ionic composition (per 1 liter):

Sodium ion - 131.0 mmol

Potassium ion - 5.4 mmol

Calcium ion - 1.8 mmol

Chloride ion - 106.3 mmol

Lactate ion - 28.5 mmol

B.05.B.B.01 Electrolytes

active ingredients: sodium chloride, potassium chloride, sodium lactate, calcium chloride dihydrate;

100 ml of solution contains: sodium chloride – 0.602 g; potassium chloride – 0.0373 g; sodium lactate – 0.3138 g; calcium chloride dihydrate – 0.0294 g;

ionic composition per 1000 ml of solution: Na + – 131 mmol, K + – 5 mmol, Ca ++ – 2 mmol, Cl – – 112 mmol, lactate – 28 mmol;

Excipients: water for injections.

Dosage form.

Solution for infusion.

Basic physicochemical characteristics: clear colorless liquid; theoretical osmolarity - 278 mOsmol/l; pH 5.5–7.5.

Pharmacotherapeutic group. Plasma replacement and perfusion solutions. Solutions for correction of disorders electrolyte balance. Electrolytes.

Code ATX B05B B01.

Pharmacological properties

Pharmacodynamics."Ringer's lactate solution" - saline solution with a balanced content of electrolytes. Replenishes the deficit in circulating blood volume. Lactate, which is part of the drug, is converted into bicarbonate anions as a result of metabolic processes, which slightly changes the blood reaction to the alkaline side. The solution also has a detoxification effect due to a decrease in the concentration of toxic products in the blood and activation of diuresis. The solution is close to isotonic.

Pharmacokinetics. When administered intravenously, the drug a short time blood osmolarity increases. The drug penetrates the tissues in about half an hour. The components of the drug are excreted in the urine.

Clinical characteristics.

Indications

Correction of water-electrolyte balance disturbances during isotonic and hypotonic dehydration due to fluid loss during vomiting, diarrhea, insufficient fluid intake into the body, biliary and intestinal fistulas, as well as to restore water-electrolyte balance when preparing patients for surgical intervention and in the postoperative period. Metabolic acidosis.

Contraindications

Hypervolemia, hypernatremia (including due to the use of corticosteroids), hyperkalemia, hyperchloremia, hypertensive dehydration, alkalosis, lactic acidosis, severe arterial hypertension, severe cardiac and/or renal dysfunction, liver failure(due to decreased formation of bicarbonate from lactate), pulmonary edema, thrombophlebitis, conditions with increased coagulability blood, decompensated heart defects.

Oliguria, anuria; acute renal failure; cerebral edema; hypercalcemia; extracellular hyperhydration.

Interaction with other drugs and other types of interactions. When using potassium-sparing diuretics, angiotensin-converting enzyme (ACE) inhibitors and potassium supplements, the risk of developing hyperkalemia increases. At simultaneous use the drug "Ringer's lactate solution" and cardiac glycosides, the toxic effect of the latter is enhanced due to the presence of Ca ++ ions in the solution.

The drug is incompatible with cefamandole, amphotericin, ethyl alcohol, thiopental, aminocaproic acid, metaraminol, ampicillin, vibramycin and monocycline.

It is possible to increase sodium retention in the body with the simultaneous use of the following drugs: non-steroidal anti-inflammatory drugs (NSAIDs), androgens, anabolic hormones, estrogens, corticotropin, mineralocorticoids, vasodilators or ganglion blockers.

Due to the presence of lactate in the drug, which alkalinizes the pH, caution should be exercised when using Ringer's lactate solution simultaneously with drugs whose renal elimination depends on pH. The renal clearance of salicylates, barbiturates, and lithium may be decreased, and that of sympathomimetics and stimulants (such as dexamphetamine sulfate, fenfluramine hydrochloride) may be increased.

Features of application

During the infusion therapy with the drug "Ringer's lactate solution" it is necessary to assess the patient's clinical condition based on monitoring the concentration of electrolytes, water-electrolyte balance, pH and pCO 2, lactate level (when carrying out massive infusions).

Application intravenous solutions may cause fluid overload, overhydration, congestion and pulmonary edema. The risk of developing dilution is inversely proportional to electrolyte concentrations. The risk of developing solution overload, which causes congestion with peripheral edema and pulmonary edema, is directly proportional to the concentration of electrolytes.

If any manifestations of a hypersensitivity reaction occur, you should immediately stop administering the solution and carry out appropriate treatment.

Since the drug contains sodium lactate, it should be used with caution in patients prone to hypernatremia (for example, with adrenocortical insufficiency, Not diabetes mellitus or massive tissue damage), and patients with heart disease; Due to the sodium ion content, the solution should be used with caution in patients with renal and cardiovascular failure, with congestive heart failure, especially in postoperative period, as well as patients with clinical conditions that are accompanied by sodium retention and edema.

Solutions that contain sodium should be administered with caution to patients using corticosteroids or corticotropin.

If calcium is prescribed, cardiac activity should be monitored using electrocardiography (ECG), especially in patients using digitalis. Serum calcium levels do not always reflect tissue calcium levels.

In patients with reduced renal excretory function, the use of the solution may lead to sodium or potassium retention in the body.

Due to the presence of calcium ions in the solution, caution is required when using blood products simultaneously, as coagulation may develop.

When prescribing parenteral calcium to patients receiving cardiac glycosides, special attention is required.

Lactate is a substrate for gluconeogenesis, so it is necessary to carefully monitor blood glucose levels in patients with type II diabetes mellitus.

Use during pregnancy or breastfeeding. The drug should be used for health reasons when the expected benefit to the mother exceeds possible risk for the fetus/child.

The ability to influence the reaction rate when driving vehicles or other mechanisms. Data are not available due to the use of the drug exclusively in a hospital setting.

Directions for use and doses

Administer intravenously. The dose is prescribed by the doctor depending on the patient’s condition. The maximum daily dose for adults is 40 ml/kg/day (average 2500 ml at a rate of 60 drops/min). The duration of treatment depends on the patient's condition.

Children. It is not used in pediatrics due to the lack of clinical trials.

Overdose

An overdose or too rapid administration of the solution can lead to water-electrolyte imbalance, alkalosis, and cardiopulmonary decompensation. In this case, administration of the drug should be stopped immediately. Carry out symptomatic therapy.

Excessive administration of lactate can lead to the development of metabolic alkalosis, which, in turn, may be accompanied by hypokalemia. Symptoms: mood swings, fatigue, shortness of breath, muscle weakness, polydipsia, polyuria, thinking disorder, arrhythmia. Muscle hypertonicity, twitching, and tetanic spasms may occur in patients with hypocalcemia.

Adverse reactions

Electrolyte imbalance: changes in the level of electrolytes (potassium, calcium, sodium, chlorine) in the blood serum; metabolic alkalosis; chloride acidosis.

General reactions of the body: hypervolemia; allergic or anaphylactic reactions(fever, itching, cough, sneezing, difficulty breathing, local or generalized urticaria, angioedema).

Changes at the infusion site: inflammation, swelling, redness, rash, itching, burning, pain, numbness at the infusion site, thrombophlebitis.

Mental disorders: panic attack.

Rapid administration of the drug may cause acute failure blood circulation and pulmonary edema.

In case of adverse reactions administration of the solution should be stopped, the patient's condition assessed and appropriate assistance provided.

Best before date

Storage conditions

Store at a temperature not exceeding 25 °C. Keep out of the reach of children.

Incompatibility. The drug must not be mixed with phosphate- and carbonate-containing solutions.

Package

200 ml or 250 ml, or 400 ml, or 500 ml bottles.

Manufacturer

Private Joint-Stock Company"Infusion".

The location of the manufacturer and the address of the place of its activities.

Ukraine, 23219, Vinnitsa region, Vinnitsa district, village. Vinnytsia Khutora, st. Nemirovskoe highway, 84A

Sodium 2-hydroxypropanoate

Chemical properties

Sodium Lactate is sodium salt lactic acid . By physical properties– white fine-crystalline powder, has a salty taste. The medicine is obtained by fermenting sugar beets or corn and neutralizing the resulting lactic acid. Molecular mass chemical compound = 112.1 grams per mole.

The substance is used in medicine and Food Industry. The product is added to food as an acidity regulator, water-retaining agent, emulsifying salt or synergist. Food supplement E325 used for preparing emulsion liqueurs, cocktails, creams, and when storing meat in vacuum packaging; for preparing brine with gherkins, olives, onions and tomatoes; to acidify the dough; included in some shampoos and liquid soaps.

Harm of Sodium Lactate

This chemical compound is approved for use in the food industry in the EU and CIS countries. Moreover, this substance is produced in small quantities in the human intestines. Due to the fact that in the additive E325 absent milk protein, it can be consumed by people with lactose intolerance. The product is not recommended to be added to baby food.

pharmachologic effect

Normalizing water and electrolyte balance.

Pharmacodynamics and pharmacokinetics

Sodium Lactate compensates for the lack of important cations (potassium, sodium, calcium) in extracellular fluid . After intravenous administration the solution is distributed throughout the tissues within half an hour, metabolized to bicarbonate , has an alkalizing effect.

Indications for use

Sodium Lactate is used:

• at hypovolemia and, accompanied by weak acidosis and normal ASR;
• in patients with severe and vomiting;
• for extensive burns, severe infections, peritonitis ;
• to maintain normal volume extracellular fluid before, during and after surgery;
• as first aid for shocked , injuries, blood loss.

Contraindications

The substance must not be used:

• with severe hepatic and acute;
• patients with pulmonary edema , lactic acidosis And alkalosis ;
• with hypertension.

Side effects

Adverse reactions from the use of Sodium Lactate occur extremely rarely. When using very large dosages, a disorder may develop water balance and electrolyte balance, hypernatremia , hypercalcemia , hypervolemia , hyperkalemia And hyperchloremia .

Instructions for use (Method and dosage)

Medicines with Sodium Lactate are administered intravenously, slowly (about 60 drops per minute). The maximum dosage is 2500 ml per day. The treatment regimen depends on the indications and condition of the patient.

Overdose

Possible electrolyte imbalance metabolic alkalosis (the solution is administered too quickly). Therapy - according to the symptoms that appear. Most often, the patient feels better after stopping the drug.

Interaction

Sodium Lactate solution can be mixed with solution atracurium besilata , from 0.5 to 0.9 mg per ml. It is advisable to use the finished mixture within 4 hours.

Caution should be exercised when treating patients simultaneously corticotropin And corticosteroids .

special instructions

The medicine is used as a temporary measure in emergency conditions. It is recommended to replace the product in case of severe deficiency of potassium, sodium and calcium ions.

Farm group:

Release form: Liquid dosage forms. Solution for infusion.

General characteristics. Compound:

Pharmacological properties:

Indications for use:

Important! Get to know the treatment

Directions for use and dosage:

Features of application:

Side effects:

Interaction with other drugs: