How to drink ACC Long effervescent tablets. Medicinal reference book geotar

Instructions
by application medicinal product for medical use

Registration number:

P N008857-240914

Trade name of the drug:

ACC ® Long.

International nonproprietary name:

Dosage form:

Compound:

1 effervescent tablet contains: active substance: acetylcysteine ​​– 600.00 mg; Excipients: lemon acid– 625.00 mg; sodium bicarbonate – 327.00 mg; sodium carbonate – 104.00 mg; mannitol -72.80 mg; lactose – 70.00 mg; ascorbic acid– 75.00 mg; sodium cyclamate – 30.75 mg; sodium saccharinate dihydrate – 5.00 mg; sodium citrate dihydrate – 0.45 mg; blackberry flavor “B” – 40.00 mg.

Description: round flat-cylindrical tablets white, with a chamfer and a notch on one side, with the smell of blackberry. There may be a faint sulfuric odor.
Reconstituted solution: colorless transparent solution with a blackberry odor, possibly a faint sulfuric odor.

Pharmacotherapeutic group:

ATX code: R05СВ01.

Pharmacological properties

Indications for use

Contraindications

Carefully: history of gastric and duodenal ulcers, bronchial asthma, obstructive bronchitis, hepatic and/or renal failure, histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching), varicose veins esophageal veins, adrenal gland diseases, arterial hypertension.

Use during pregnancy and breastfeeding

Directions for use and doses

Inside, after eating.
Effervescent tablets should be dissolved in one glass of water. Tablets should be taken immediately after dissolution, in exceptional cases You can leave the ready-to-use solution for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug. For short-term colds Duration of treatment is 5-7 days. At chronic bronchitis and cystic fibrosis, the drug should be taken more long time to achieve a preventive effect.
In the absence of other prescriptions, it is recommended to adhere to the following dosages:
Mucolytic therapy:
Adults and children over 14 years of age: 1 effervescent tablet 1 time per day (600 mg).

Side effect

According to the World Health Organization (WHO) unwanted effects classified according to their frequency of development as follows: very common (≥1/10), common (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10000, <1/1000) и очень редко (<1/10000); частота неизвестна (частоту возникновения явлений нельзя определить на основании имеющихся данных).
Allergic reactions
infrequently: skin itching, rash, exanthema, urticaria; angioedema, decreased blood pressure, tachycardia;
very rarely: anaphylactic reactions up to anaphylactic shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).
From the respiratory system
rarely: shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).
From the senses
infrequently: noise in ears.
From the gastrointestinal tract
infrequently: stomatitis, abdominal pain, nausea, vomiting, diarrhea, dyspepsia.
Others
very rarely: headache, fever, isolated reports of bleeding due to a hypersensitivity reaction, decreased platelet aggregation.

Overdose

Interaction with other drugs

With the simultaneous use of acetylcysteine ​​and antitussives due to suppression of the cough reflex, sputum stagnation may occur.
When used simultaneously with antibiotics for oral use (penicillins, tetracyclines, cephalosporins, etc.) they may interact with the thiol group of acetylcysteine, which can lead to a decrease in their antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine ​​should be at least 2 hours (except cefixime And loracarbefa).
Simultaneous use with vasodilating agents And nitroglycerin may lead to increased vasodilatory effects.

special instructions

Impact on the ability to drive vehicles and machinery

There is no data on the negative effect of the drug ACC ® Long in recommended doses on the ability to drive vehicles or operate machinery.

Special precautions when disposing of unused medicinal product

There is no need for special precautions when disposing of unused ACC ® Long.
Close the tube tightly after taking the tablet!

Release form

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 30 °C.
Keep out of the reach of children.

Best before date

3 years.
Do not use after expiration date.

Vacation conditions

Manufacturer

Pharmacodynamics: mucolytic agent, thins sputum and facilitates its separation. The action is associated with the ability of free sulfhydryl groups of acetylcysteine ​​to break intra- and intermolecular disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolymerization of mucoproteins and a decrease in sputum viscosity. In addition, it reduces induced hyperplasia of mucoid cells, enhances the production of surfactants by stimulating type II pneumocytes, and stimulates mucociliary activity, which leads to improved mucociliary clearance. Remains active against purulent sputum, mucopurulent and mucous sputum. Increases the secretion of less viscous sialomucins by goblet cells, reduces the adhesion of bacteria to the epithelial cells of the bronchial mucosa. Stimulates mucous cells of the bronchi, the secretion of which is lysed by fibrin. It has a similar effect on the secretions formed during inflammatory diseases of the ENT organs. It has an antioxidant effect due to the presence of an SH group that can neutralize electrophilic oxidative toxins. Acetylcysteine ​​easily penetrates into the cell and is deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione is a highly reactive tripeptide, a powerful antioxidant, cytoprotector that traps endogenous and exogenous free radicals and toxins. Acetylcysteine ​​prevents exhaustion and helps increase the synthesis of intracellular glutathione, which is involved in the redox processes of cells, thus promoting the detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for paracetamol poisoning. Paracetamol exerts its cytotoxic effect through the progressive depletion of glutathione. The main role of acetylcysteine ​​is to maintain proper levels of glutathione concentration, thereby providing protection to cells. Protects alpha 1-antitrypsin (elastase inhibitor) from the inactivating effects of HOCl, an oxidizing agent produced by myeloperoxidase of active phagocytes. It also has an anti-inflammatory effect (by suppressing the formation of free radicals and reactive oxygen-containing substances responsible for the development of inflammation in the lung tissue). Pharmacokinetics: ACC Long is well absorbed when taken orally. It is immediately deacetylated to cysteine ​​in the liver. In the blood, a mobile equilibrium of free acetylcysteine ​​and its metabolites (cysteine, cystine, diacetylcysteine) is observed, free and bound to plasma proteins. Due to the strong first-pass effect through the liver, the bioavailability of acetylcysteine ​​is about 10%. Acetylcysteine ​​is distributed both unchanged (20%) and in the form of active metabolites (80%), penetrates into the intercellular space, is distributed mainly in the liver, kidneys, lungs and bronchial secretions. The volume of distribution of acetylcysteine ​​varies from 0.33 to 0.47 l/kg, the maximum concentration in plasma is reached 1-3 hours after oral administration and is 15 mmol/l, binding to plasma proteins is 50% 4 hours after administration and decreases to 20% after 12 hours. Penetrates through the placental barrier. After oral administration, acetylcysteine ​​is quickly and extensively metabolized in the intestinal wall to form the pharmacologically active metabolite cysteine, as well as diacetylcysteine, cystine). It is excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine), a small part is excreted unchanged through the intestines. The half-life of the drug from blood plasma (T1/2) is approximately 1 hour; if liver function is impaired, the value increases to 8 hours.

ACC Long contains the active ingredient acetylcysteine (600 mg), as well as some additional components: sodium bicarbonate, citric acid, mannitol, sodium carbonate, ascorbic acid, , sodium citrate dihydrate, sodium saccharinate dihydrate, flavoring.

Release form

ACC Long is produced in effervescent tablets. ACC tablets are round, white, with a scratch on one side and a smooth surface on the other. The tablets have a blackberry flavor.

Once the tablet is dissolved in water, the resulting solution is colorless and has a blackberry scent. The tablets are packaged in polypropylene tubes of 6, 10 or 20 pieces.

pharmachologic effect

The product has a mucolytic effect. Since the structure of the acetylcysteine ​​molecule contains sulfhydryl groups, this ensures the rupture of disulfide bonds of acidic mucopolysaccharides of sputum. As a result, the viscosity of the mucus decreases.

ACC Long is also active if the patient produces purulent sputum.

Provided that the drug is used for the purpose of prevention, the severity and frequency of exacerbations in people who are sick is reduced cystic fibrosis And chronic .

Pharmacokinetics and pharmacodynamics

Once in the body, it is absorbed quickly. Metabolism occurs in the liver, resulting in the formation of a pharmacologically active metabolite - , Also , diacetylcysteine , mixed disulfides.

When taken orally, the level of bioavailability is 10% (since there is a pronounced first-pass effect). The highest level of concentration is determined after 1–3 hours. 50% bound to plasma proteins. Excreted from the body through the kidneys. The half-life is approximately 1 hour; if liver function is impaired, the half-life is 8 hours. Penetrates through the placental barrier. There is no evidence of penetration through the BBB.

Indications for use

ACC Long is used in the following cases:

• for diseases of the respiratory system, which are accompanied by the formation of viscous sputum, which is difficult to separate (acute and chronic bronchitis, bronchiectasis , pneumonia , cystic fibrosis , );
• acute and chronic;

Contraindications

ACC 600 is contraindicated for use in the following cases:

• at and ;
• when the patient is under 14 years of age;
• with high sensitivity to the components of the drug.

Side effects

The following side effects may occur during treatment:

• nervous system: in rare cases - tinnitus;
• digestive system: , vomit , , nausea , ;
• heart and blood vessels: , lowering blood pressure;
• allergy: bronchospasm (in isolated cases - mainly in patients with bronchial hyperreactivity), , skin rash, ;
• other manifestations: bleeding - in isolated cases.

Effervescent tablets ACC Long, instructions for use (Method and dosage)

The drug 600 mg is usually prescribed to patients over 14 years of age. The instructions for use of ACC Long 600 stipulate that the patient should take 1 effervescent tablet per day, this dose corresponds to 600 mg of acetylcysteine.

The tablet is dissolved in 1 glass of water and should be taken immediately after the tablet has dissolved. It is allowed to take the prepared solution for two hours in exceptional cases.

If we are talking about colds, then treatment continues for 5-7 days. If it is necessary to treat other diseases that have a longer course, the duration of therapy is determined by the doctor. People with chronic bronchitis are given longer treatment to ensure infection is prevented.

The drug is taken after meals.

Overdose

In case of overdose, the following symptoms may occur: abdominal pain, vomiting, diarrhea, nausea. No severe symptoms were observed in case of overdose.

In such cases, symptomatic treatment is carried out.

Interaction

In the case of simultaneous use of acetylcysteine ​​and cough suppressants, due to suppression of the cough reflex, the likelihood of mucus stagnation increases. Therefore, such medications must be combined with caution.

If treatment with acetylcysteine ​​and , the vasodilatory effect of nitroglycerin may be enhanced.

Acetylcysteine ​​is not compatible pharmaceutically with a number of (cephalosporins, penicillins, , Tetracycline ) and with proteolytic ones.

Under the influence of acetylcysteine, the level of absorption of cephalosporins decreases, , penicillins. In this regard, it is necessary to observe an interval between taking these medications of at least 2 hours.

If acetylcysteine ​​comes into contact with rubber or metals, sulfides with a characteristic odor are formed.

Terms of sale

ACC Long can be purchased without a prescription.

Storage conditions

The storage temperature should not be more than 30 degrees; it should be stored in a dry, dark place, out of reach of children. After the tablet has been removed, you need to close the tube tightly.

Best before date

The drug is stored for 3 years.

special instructions

It is important to use ACC Long with caution to treat patients with bronchial asthma and obstructive bronchitis. In this case, it is necessary to ensure systematic monitoring of bronchial obstruction.

If side effects occur during therapy, you should stop taking it and consult a specialist.

During pregnancy and lactation

Since there is no sufficient information on the use of the drug during pregnancy, as well as during breastfeeding, the use of the drug for the treatment of patients during these periods is not practiced.

As well as many other respiratory diseases, accompanied by difficult to clear sputum. Pregnancy and are contraindications to the use of the drug. Long is used only after reaching the age of 14.

Dosage form

Side effects

Among the undesirable clinical effects that may be observed while taking long:

• itchy skin;
• dyspnea;
• noise in ears;
• headache (very rare);
• skin rashes;
• bronchospasm;
• pain in the abdominal area;
• fever;
• nausea;
• bleeding (extremely rare);
• Quincke's edema;
• decreased blood clotting;
• decreased blood pressure;
• diarrhea;
• tachycardia;
• dyspeptic symptoms;
• anaphylactic reactions (very rare);
• Lyell's syndrome (very rare);
• Stevens-Johnson syndrome.

Interaction with other drugs

In the case of combined use of long and antitussive medications, there is a high probability of sputum stagnation.

When used in combination with antibiotic drugs for oral administration, there is a risk of their interaction with the thiol group of acetylcysteine, which can provoke a decrease in the antibacterial effect of these drugs. In view of this fact, the interval between the use of antibiotics and acetylcysteine ​​should be at least 2 hours.

• diarrhea;
• heartburn;
• nausea;
• stomach ache.

If they occur, symptomatic therapy is carried out.

Storage conditions

The product is indicated for over-the-counter release from pharmacies.

This medication offers a wide range of release forms: tablets, syrup and solution for infusion. Active component – ​​. Indications are acute and chronic bronchopulmonary pathologies associated with disruption of bronchial secretory processes and weakening of the movement of sputum. It is not used in patients under 12 years of age.

This product contains the substance of the same name. This medication is used for acute and chronic bronchitis of various origins, bronchial asthma, bronchiectasis, pulmonary tuberculosis, as well as for sanitation of the bronchi before surgical interventions and for the prevention of postoperative complications. The product is produced in the form of tablets and syrup. In pediatrics it is used starting from the age of 3 years.

Mukosol is available in capsule form. The active component of the drug is carbocisteine. The medication is used for the same indications as Long: pathologies of the respiratory system, accompanied by the formation of viscous sputum. Not recommended for use by children. In pregnant and lactating women, use with caution according to doctor's instructions.

Price

The cost of a long is on average 423 rubles. Prices range from 224 to 588 rubles.