Glucose and ascorbic acid intravenous indications. Purpose of ascorbic acid

Many children are familiar with small round yellow dragees from a large jar: the use of ascorbic acid in most kindergartens and schools is a common practice for the prevention of beriberi and strengthening immunity. Ascorbic acid with glucose - the same vitamin in a low concentration, but enhanced with an additional substance necessary for the child and adult body. In what cases should it be taken and can it be harmful?

What is ascorbic acid for?

Stimulation of the synthesis of corticosteroid hormones, improved absorption of iron (which helps to get rid of anemia), general strengthening of the immune system - this is what they mainly take ascorbic acid for, which few people perceive as a full-fledged drug. However, vitamin C, especially in combination with glucose, can have a serious effect on the body due to its rapid penetration into blood cells and tissues in the form of dehydroascorbic acid. benefit this drug can be assessed even with frequent headaches caused by blood clotting.

Regarding the pharmacodynamics of ascorbic acid:

• Metabolism occurs in the kidneys, most of it is excreted as oxalate.
• The rate of excretion by the kidneys depends on the dose - high ones come out faster.

Composition and form of release

The main components of the drug are already indicated in the name - this is vitamin C and glucose, they have one concentration, if we consider the most common form of release: hard tablets (chewable tablets are less common, the dose of active components is increased by 2 times). They are white, flat central risk and without a shell - the photo shows that they do not differ from the classic ascorbic. The taste is sour. Additionally, the composition includes substances that give the tablets a dense shape, so it looks like this:

What is useful ascorbic acid with glucose

In addition to eliminating the deficiency of specific substances, vitamin C is a participant carbohydrate metabolism, necessary for normal blood clotting, plays an important role in the synthesis of hormones (mainly steroid) and collagen. With prolonged use of ascorbic acid, a person does not need to additionally take folic acid, the need for pantothenic acid and retinol disappears. Additionally, she:

• It has an antiaggregatory effect.
• Stimulates the synthesis of prothrombin.
• Blocks the release of histamine.

Indications for use

Ascorbic acid with glucose for children is prescribed mainly for general strengthening of the body. Adults have more reasons to take it: firstly, ethanol and nicotine deplete ascorbic acid reserves (ethanol clearance increases), therefore, if they are abused, periodic administration of this drug is mandatory. Secondly, ascorbic acid with glucose is prescribed to adults as a reducing agent in the case of:

• fractures;
• bleeding;
• intoxications;
• poor absorption of iron;
• infectious diseases;
• poor skin regeneration;
• overdose of anticoagulants.

Method of application and dosage

For solution practiced intravenous administration, for tablets - oral administration (sublingual resorption). Dosages are determined by the age of the patient, glucose sensitivity and the reason for taking the drug. Due to the fact that the combination of ascorbic acid and glucose actively promotes the synthesis of corticosteroids, doctors advise adhering to the official instructions, especially in pediatric therapy.

Pills

Taking this form - inside, for prevention or treatment, the duration of the course is determined by the doctor, the dosage can also be adjusted. Reception time does not depend on food. According to the official instructions, the application is as follows:

• For prevention, children are given 50 mg once a day, for treatment (and to improve the absorption of iron preparations) - 100 mg up to 3 times a day.
• Adults are given 100 mg per day for prevention and the same amount, but up to 5 times a day, if you need to increase iron absorption or for treatment.

Glucose with ascorbic acid intravenously

This form of the drug is used through droppers in medical institutions. The powder is diluted with water (up to 2 ml per ampoule), slowly injected intravenously or intramuscular way. Dosages are:

• Children up to 2 ml of a classic (5%) solution once a day, or 4 ml of a 2.5% solution.
• Adults are prescribed glucose and ascorbic acid in 3 ml of a standard solution one-time or 6 ml of a weaker solution (2.5%).

special instructions

Is ascorbic acid with glucose useful during pregnancy is a question that worries most expectant mothers, because while waiting for a child, a woman's body is faced with a rapid depletion of vitamin reserves. However, unlike glucose, ascorbic acid can cause harm to the fetus if it has been taken for a long time in high doses, which will provoke a withdrawal syndrome after. For this reason, doctors advise pregnant women to start taking the drug only with a clear deficiency of vitamin C and in late periods pregnancy (mainly 3rd trimester). The norm is 100 mg. With lactation 120 mg.

A few more nuances from the official instructions:

• Ascorbic acid has a stimulating effect on the rate of formation of corticosteroid hormones, therefore, when long-term use you need to control blood pressure and kidney function.
• If the patient's blood test shows high content iron, the dose of ascorbic acid should be reduced.
• If treatment with ascorbic acid and glucose is performed while taking oral contraceptives, the bioavailability of estrogen will increase.
• The absorption of ascorbic acid is reduced in the case of simultaneous treatment with salicylates (plus the risk of adverse reactions on them) and when taken with alkaline drink.
• Vitamin C improves the absorption of penicillin.

Separately official instruction mentions that vitamin C and glucose increase the excretion of mexiletin, making it less effective indirect anticoagulants, may affect the excretion acetylsalicylic acid and drugs that have an alkaline reaction. If, on the background of the use of vitamin C, the intake of barbiturates was observed, ascorbic acid will be excreted in the urine.

Contraindications

To a greater extent, ascorbic acid only benefits the body, so the list of contraindications to it is very short. It can only harm individuals:

• with thrombosis;
• with thrombophlebitis;
• under 6 years old.

Since this vitamin compound is characterized high level glucose, it should be used with caution in individuals with:

• diabetes;
• oxalate kidney stones;
• nephrourolithiasis.

Ascorbic acid - side effects

According to doctors, even vitamins can be harmful, and this does not require an overdose of ascorbic acid with glucose: even when following the instructions, a person can experience nausea, get skin rashes and itching (allergy). Additionally, doctors note:

• The occurrence of diarrhea, intestinal spasms.
• Hypokalemia and thrombocytosis in the test results.
• Distortion of indicators on the activity of transaminases, bilirubin.
• In the presence of tumors that form metastases, it is undesirable to take ascorbic acid with glucose, since the acceleration of this process is not excluded.

Overdose

Most of negative reactions the body is a response to an excess of ascorbic acid, especially if the deficiency was not initially observed. An overdose is possible in the case of a single dose of 10 tablets, which will be characterized by headaches, sleep disturbance, severe nausea(may turn into vomiting), intestinal upset. With long-term use a large number this drug may impair capillary permeability.

The response to an excess of glucose is:

• inhibition of the function of the insular apparatus (pancreas);
• dysfunction of the glomerular apparatus (kidney).

Terms of sale and storage

With all the potential harm from an overdose of the drug, you can buy ascorbic acid tablets with glucose freely - a doctor's prescription is not needed. The shelf life for tablets is 1 year, solutions (pure vitamin C) are also stored for a year if the concentration active substance is 50 mg, and 1.5 years for a concentration of 100 mg. Storage is carried out at a temperature not exceeding 25 degrees for tablets and 15 degrees for ampoules, with mandatory protection of the drug from light.

The price of ascorbic acid with glucose

The cost of this drug has always been in the budget zone: if you do not consider the format chewable tablets, which do not differ from the standard ones in terms of the degree of benefit, a package of 10 pcs. can be bought for 11 rubles, and a pack of 40 pcs. - for 39 rubles. The price mainly depends on the manufacturer and the level of the pharmacy. An approximate picture is as follows:

Video

Every time when colds and infectious diseases take over the body, and it starts to sound the alarm, all kinds of supportive drugs and vitamins are used. To restore the usual work of the body, its prevention and strengthening the walls of blood vessels, ascorbic acid with glucose is actively used.

Many people are captivated by its sweet-sour taste, unusual texture and ease of use. It is not for nothing that many children perceive ascorbic acid as sweets and use them with pleasure. What is useful ascorbic acid with glucose? How is it applied? Is her demand and the trust placed in her justified? What secrets do ascorbs hide and why do they still not give up their positions? Consider the instructions for use, indicate their benefits and possible harm, as well as talk about the features and precautions for use.

Ascorbic acid: definition

A large amount contains vitamin C. Dissolving in the body, it affects all the processes of human life. Vitamin C is an auxiliary element for the absorption of substances important for life. An overdose of them is unlikely and occurs extremely rarely.

The daily requirement of vitamin C for a person is 100 mg. This amount is used for preventive purposes and to maintain healthy condition. At colds it is desirable to double the dose.

Ascorbic acid with glucose: composition and appearance

It would seem that glucose is considered a light and harmless vitamin, but its instructions for use have some rules that must be followed. One tablet of ascorbic acid contains 100 mg of ascorbic acid, 877 mg of glucose, as well as other additional components, which, depending on the manufacturer, may differ slightly.

Often, ascorbic acid with sugar is produced in ordinary cardboard packages, each of which contains two blisters of ascorbic acid and instructions for use. Vitamins white color, large enough, have a flattened rounded shape. Another popular form of release is 10 vitamins in a paper wrapper, like from sweets.

The effect of vitamins on the body

Ascorbic acid with sugar improves and normalizes many processes in the body. It promotes regenerating functions, improves metabolic processes, promotes the breakdown of substances. Vitamin boosts immunity, which allows you to quickly fight viruses and infections. Thanks to him, the body's need for other beneficial acids is significantly reduced.

Vitamin C is usually well absorbed by the intestines. After its use, it takes about half an hour for it to completely penetrate the tissue cells and be distributed throughout the body.

It's no secret that vitamin C is quite often found in the formulations of many drugs. Do not forget about the most famous and favorite drug - ascorbic acid with glucose. Everyone knows about it since childhood, when at the slightest sign of illness such ascorbic acid was used to restore and strengthen immunity.

With the help of ascorbic acid, metabolic processes are normalized and liver performance is significantly improved. Ascorbic acid with sugar is an excellent energy boost for the whole body.

• if unusual irritability, fatigue and weakness appear;
• if immunity is weakened (susceptibility to infections and viruses increases);
• if the liver is concerned;
• after poisoning;
• in the formation of teeth oral cavity and bleeding gums;
• if overtaken by vitamin deficiency;
• during pregnancy;
• during the formation and growth of the body;

To optimize the tissue metabolism of the body, use ascorbic acid with glucoseintravenously. This often happens in clinical cases, which are caused by the lack of this and its urgent introduction. This method is used for bleeding (hepatic, uterine and others), in case of infectious diseases, bone fractures, sometimes during pregnancy, etc. The amount of fluid administered individually, this determines the severity of the disease.

The benefits and harms of a vitamin preparation

It is worth noting that it is rather difficult to overdo it with vitamin C, since there is no reserve of it in the human body. The body is able to digest everything that "enters" along with the products, and the possible excess is excreted through the intestinal, renal channels and sweat glands. In pharmacies, a vitamin preparation is sold without a doctor's prescription, which confirms its safety and reduces the likelihood of any complications.

? In rare cases excessive passion Vitamin D can cause the following complications:

• The density of the blood increases.
• Excessive consumption of foods with vitamin C can disrupt the processes of the pancreas.
• In case of intolerance to the substance, an allergy is possible.
• Regular overdose can disrupt the functioning of the kidneys (stone formation, urination disorders).
• At frequent use vitamin with food may cause heartburn and a feeling of nausea.

Ascorbic acid with glucose is present on the shelves of all pharmacies, but its benefits and harms in some cases may differ. Despite the fact that ascorbic acid is considered a completely harmless drug, it should be used no more than 100 mg per day.

Vitamin should be used, especially carefully observing some processes occurring in the body. The work of the kidneys and pancreas, periodic pressure measurements - this is what you should pay attention to when using the drug. No need to joke with the body and oversaturate it, because any vitamins are useful only when they are used in moderation.

If a person's iron content in the body is higher than normal, then the use of ascorbic acid must be reduced and the level of glucose in the blood should be periodically determined.

To save everything beneficial features ascorbic acid, it must be stored for no more than one year, preferably where there is no moisture, light and access for children.

Ascorbic acid 0.1 g with glucose tablets is a drug belonging to the group vitamin preparations, intended for the correction of conditions accompanied by a deficiency of vitamin C, as well as for the prevention of such ailments.

What is the composition and form of release of the drug ascorbic acid with glucose?

As part of this medicinal product there are two active component, in fact, it is ascorbic acid, in the amount of 100 mg per tablet, and glucose, the content of which is 870 milligrams.

The drug is produced in tablet form. The package supplied contains 10 pieces. Vacation from pharmacies is carried out without a doctor's prescription.

What is the pharmacological action of ascorbic acid with glucose?

Vitamin C, also known by the “name” ascorbic acid, is a substance that has a whole range of beneficial effects for humans, from stimulating defensive reactions until normalization of metabolic processes. I will dwell on this in a little more detail.

First of all, vitamin C is the strongest stimulator of non-specific protective reactions of the body. Under its influence speed and productivity increases biological processes responsible for the production of interferons, substances that can protect healthy cells from viral invasion. This circumstance is especially important in an epidemic dysfunctional period.

It is impossible to ignore the ability of ascorbic acid to stimulate the formation of such protein complexes as collagen and elastin. Let me remind you that these substances are part of connective tissue found in almost every organ. Over the years, their number has been steadily decreasing, which can lead to the development of certain diseases.

Ascorbic acid is a "catalyst" of biochemical reactions responsible for the absorption and utilization of iron in the body. Available only enough of this substance, the processes of hematopoiesis and oxygen delivery to tissues and organs can normally proceed.

Vitamin C is a stimulant for the formation of certain hormones. In particular endocrine activity bodies such as thyroid or adrenal glands, in many respects, is determined by the presence of ascorbic acid, moreover, in sufficient quantities. We should not forget about the formation of testosterone and estrogen, and so on.

What are the indications for use of the drug ascorbic acid with glucose?

The drug Ascorbic acid 0.1 g with glucose is indicated for use in the presence of the following conditions:

Increased need for vitamin C during the period of active growth;
Pregnancy;
The period of recovery after serious illness;
Breast-feeding;
Treatment of diseases caused stressful conditions;
Increased mental and physical stress.

What are the contraindications for use of ascorbic acid with glucose?

The list of absolute contraindications includes the following conditions:

Hypersensitivity to the drug;
Childhood patient less than 6 years old;
Tendency to thrombophlebitis.

Relative contraindications: deficiency of the enzyme glucose-6-phosphate dehydrogenase, hemochromatosis, thalassemia, in addition to sideroblastic anemia, urolithiasis disease as well as diabetes mellitus.

What is the dosage and use of the drug ascorbic acid with glucose?

This medicine should be taken only after meals. The dosage depends on indications and age of the patient.

So for prophylactic purposes, adult patients should use 50-100 mg of the drug once. Adolescents from 14 to 18 years - 75 mg, children aged 14 to 6 - 50 mg. Duration of admission - about 2 weeks.

WITH therapeutic purpose it is customary to prescribe 50-100 mg 3-5 times a day for the adult category of patients. Children 50 - 100 mg 2 or 3 times a day. The duration of therapy should be determined by a specialist based on clinical picture diseases and outcomes laboratory research.

special instructions

For patients with diabetes has its own information in the annotation. She tells them that they can use such a drug as Ascorbic acid with glucose. Instructions for use only specifies that one tablet of the drug contains 0.08 bread units. To avoid development negative consequences adjust the amount of carbohydrates you eat.

Can there be an overdose from the consumption of ascorbic acid with glucose?

In case of unintentional overdose, the following symptoms: headache, severe nervous excitability, vomiting, nausea, gastritis, pancreatic damage and some other signs.

Treatment is as follows: discontinuation of the drug, and symptomatic therapy. There is no specific antidote.

What are the side effects of the drug ascorbic acid with glucose?

Undesirable manifestations of therapy are very rare, in most cases the medicine is well tolerated by patients. Sometimes the following are possible side effects: allergic reactions, damage to the insular apparatus of the pancreas, damage to the gastric mucosa and duodenum, changes on the hemogram.

What are the analogues of ascorbic acid with glucose?

The drug can be replaced by the drug Ascorbic acid + dextrose.

Conclusion

You should carefully follow all the recommendations of the attending physician, both in relation to taking medications and in terms of other recommendations: the regime of work and rest, dietary habits and physical activity. If there are negative changes in well-being, you should immediately notify the doctor.

Ascorbic acid with glucose tablets is medicinal product, which belongs to the vitamin group. It is intended to correct conditions caused by a significant lack of vitamin C.

A certain dosage can be used as prophylactic against certain ailments during pregnancy. In diabetes mellitus, the use of this remedy has clear limitations.

Composition and form of release

The product contains two active components:

• ascorbic acid (100 mg per tablet);
• glucose (870 mg per tablet).

Ascorbic acid is produced in a tablet format. Even during pregnancy, sale in pharmacy chains is possible without presenting a prescription from the attending physician.

Pharmacological effects on the body

Ascorbic acid (vitamin C), if the dosage is right, has a whole range of health benefits at once. This is not only a qualitative stimulation of the body's defense reactions, but also the normalization of metabolic processes.

Under the influence of this acid, the speed and productivity of some biological processes increases, for example, the quality of the production of interferons (special substances that protect healthy cells from virus attack). This fact is especially relevant for diabetics during viral epidemics.

Without vitamin C, the production of testosterone and estrogen is impossible.

The use of ascorbic acid is in its ability to stimulate the processes of the formation of protein complexes - elastin and collagen. These substances are components of the connective tissue, which in without fail present in almost all human organs. With the passage of age total of such cells is constantly decreasing, which provokes the development of certain ailments.

Vitamin C is a catalyst for all biochemical reactions that are responsible for the absorption and excretion of iron in the body of a diabetic. Only under the condition of a sufficient amount of acid will benefit during pregnancy be obtained. Ascorbic acid and glucose help the processes of hematopoiesis and oxygen delivery to tissues and organs to proceed adequately.

In diabetes, vitamin C should be used with extreme caution!

The drug stimulates the formation of some important hormones. The instruction says that endocrine activity thyroid gland and adrenal glands will be due precisely to the presence of ascorbic acid in the amount necessary for the body.

When should vitamin C be used?

The drug Ascorbic acid with glucose will be indicated for use in the following cases:

1. during pregnancy;
2. during lactation;
3. excessive need for vitamin C (during active growth);
4. with high physical and mental stress;
5. after severe illness;
6. in the treatment of ailments caused by stress.

Contraindications for use

The instruction gives information that there are absolute contraindications to the use of the drug:

• predisposition to thrombophlebitis;
• children's age up to 6 years;
• excessive sensitivity to the drug.

There are also relative contraindications:

1. deficiency of the enzyme glucose-6-phosphate dehydrogenase;
2. sideroblastic anemia;
3. hemochromatosis;
4. thalassemia;
5. urolithiasis disease.

Description of the features of the drug

It is necessary to use ascorbic acid strictly after eating.

The benefit of the drug will be obtained only in this case. The dosage depends entirely on the age of each individual patient, as well as on individual indications.

In order to prevent vitamin C deficiency, it should be consumed:

• adult patients - from 50 to 100 mg of the drug 1 time per day;
• during pregnancy - 100 mg once;
• adolescents from 14 to 18 years old - 75 mg 1 time per day;
• children from 6 to 14 years old - 50 mg 1 time per day.

The duration of the course is 14 days. During pregnancy, this period should be agreed with the attending physician, which should be followed.

For therapeutic purposes, the dosage will be as follows:

1. adult patients - from 50 to 100 mg of the drug 3-5 times a day;
2. during pregnancy - 100 mg 3-5 times a day;
3. adolescents from 14 to 18 years old - 50 - 100 mg 3-5 times a day;
4. children from 6 to 14 years old - 50 - 100 mg 3 times a day.

For medicinal purposes, the vitamin must be used, based on the recommendations of the doctor. The doctor will prescribe the dosage depending on the picture of the course of the disease and the results of laboratory tests. This is especially true during pregnancy.

Special instructions for diabetics

For those with diabetes, there are special recommendations by application. The instruction states that the drug should be used under strict medical supervision. It should be borne in mind that 1 tablet of the drug contains 0.08 bread units (XE).

Taking vitamin C, a diabetic should adjust the amount of carbohydrates consumed. Otherwise, the benefit of the drug will be doubtful.

Cases of overdose

If an unintentional overdose occurs, then the following symptoms may occur:

• headache;
• excessive nervous excitability;
• gagging;
• bouts of nausea;
• manifestations of gastritis;
• pancreatic damage.

If these symptoms occur, you should stop using the drug and take symptomatic therapy. There is no specific antidote.

Negative consequences

Adverse reactions when taking a vitamin are extremely rare. As a rule, acid is well tolerated by patients. Sometimes the following negative consequences can be observed:

1. allergic reactions;
2. damage to the mucous membrane of the stomach and duodenum;
3. hemogram changes;
4. damage to the insular apparatus.

In pharmacology, there is an analogue of the drug Ascorbic acid and glucose - this is a combination of vitamin C and dextrose.

Manufacturer: Eikos-Pharm TOO

Anatomical-therapeutic-chemical classification: Ascorbic acid in combination with other drugs

Registration number: No. RK-LS-5 No. 015550

Date of registration: 13.03.2017 - 13.03.2022

Instruction

• Russian

Tradename

Ascorbic acid with glucose

International non-proprietary name

Dosage form

Pills

Compound

One tablet contains

active substances: ascorbic acid - 50 mg

glucose monohydrate - 483 mg

(in terms of glucose 100% 439 mg)

Excipients: potato starch, talc, calcium stearate.

Description

Tablets are round, flat white with beveled edges, with a risk on one side.

Pharmacotherapeutic group

Ascorbic acid in combination with other drugs.

ATX code A11GB

Pharmacological properties

Pharmacokinetics

After oral administration, ascorbic acid is completely absorbed from gastrointestinal tract and is widely distributed in body tissues. The concentration of ascorbic acid in blood plasma is normally approximately 10-20 μg / ml. The depot level in the body is about 1.5 g. The concentration of ascorbic acid in leukocytes and platelets is higher than in erythrocytes and in plasma. In deficient states, the concentration in leukocytes decreases later and more slowly and is considered as a better criterion for assessing deficiency than plasma concentration.

Plasma protein binding is about 25%.

Ascorbic acid is reversibly oxidized to form dehydroascorbic acid, some of it is metabolized to form ascorbate-2-sulfate, which is inactive and excreted in the urine.

Ascorbic acid taken in excessive amounts is rapidly excreted unchanged in the urine, usually when the daily dose is exceeded.

The absorption of ascorbic acid decreases with the simultaneous use of fresh fruit and vegetable juices and alkaline drinks.

Glucose is easily absorbed and rapidly distributed to all body tissues. The main metabolic pathways are glycolysis and aerobic oxidation to carbon dioxide and water, resulting in the formation of ATP and other macroergic compounds.

Pharmacodynamics

Ascorbic acid is involved in redox reactions, tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, lipid and protein synthesis, iron metabolism, cellular respiration processes, blood coagulation, normalization of capillary permeability, contributes to the formation of resistance to infections. Reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid, helps to increase the body's resistance; improves the absorption of iron, facilitating its deposition in a reduced form, has antioxidant properties. Ascorbic acid is necessary for the formation of intracellular collagen, it is required to strengthen the structure of teeth, bones and capillary walls.

Glucose takes part in carbohydrate and energy metabolism, improves the body's detoxification potential, thus optimizing a number of its functions. When glucose is metabolized in tissues, a significant amount of energy is released, which is necessary for the life of the body.

Indications for use

Prevention and treatment of hypo- and avitaminosis of vitamin C. Ensuring the body's increased need for vitamin C and glucose in case of:

Growth period

Pregnancy and lactation

Severe physical and mental stress

Overwork

The recovery period after a long, severe illness

postoperative period

Stressful state

IN winter period at increased risk development of infectious diseases.

Dosage and administration

Inside, after eating.

For the prevention of hypovitaminosis C - adults 50-100 mg / day (1-2 tablets).

Children: 6-14 years old - 50 mg / day (1 tablet), 14-18 years old - 75 mg / day (1.5 tablets).

During pregnancy and lactation -300 mg / day (6 tablets) for 10-15 days, then 100 mg / day (2 tablets) throughout the entire lactation period. For therapeutic purposes: children 50-100 mg (1-2 tablets) 2-3 times a day, adults 50-100 mg (1-2 tablets) 3-5 times a day for 2 weeks. Maximum daily dose for adults 1000 mg (20 tablets). The duration of treatment depends on the nature and course of the disease.

Side effects

hyperglycemia

Glucosuria, inhibition of glycogen synthesis

Arterial hypertension

Nausea, vomiting, heartburn, diarrhea, spasmodic epigastric pain

Headache, feeling tired

Skin rash

Transient decrease in urine pH

Inhibition of the function of the insular apparatus of the pancreas

Inhibition of kidney function

allergic reactions

Hypervitaminosis

With prolonged use of large doses - increased excitability of the central nervous system, sleep disturbance

Laboratory indicators

thrombocytosis

Hyperprothrombinemia

erythropenia

Neutrophilic leukocytosis

hypokalemia

Formation of urinary, cystine and oxalate kidney stones.

Contraindications

Hypersensitivity to the components of the drug

Increased blood clotting

Thrombophlebitis, tendency to thrombosis

Diabetes

Deficiency of glucose-6-phosphate dehydrogenase.

kidney failure

Hemochromatosis

Thalassemia

Children's age up to 6 years

Drug Interactions

Aluminum-containing antacids

The simultaneous use of aluminum-containing antacids and ascorbic acid is not recommended, as it can lead to accumulation of toxicity in bone tissue and the central nervous system.

Salicylates

Increases the concentration of salicylates in the blood and increases the risk of developing oxalaturia.

Disulfiram

In some cases, ascorbic acid can be used as a specific antidote to eliminate the symptoms of the interaction of ethanol with disulfiram. It should be expected that the simultaneous use of ascorbic acid will inhibit the effectiveness of disulfiram when used in patients with withdrawal symptoms.

Drugs that affect urine acidity (eg, amphetamine, mexiletine)

Increasing the acidity of the urine with ascorbic acid can cause the precipitation of cysteine, uric acid or oxalate stones and alters the excretion of some other drugs used at the same time. The excretion of some drugs can be increased by increasing the acidity of the urine. The patient's condition should be constantly monitored. If an interaction reaction is observed, it is necessary to decide whether to cancel or adjust the dose of ascorbic acid. warfarin Large doses of ascorbic acid reduce the effect of the anticoagulant warfarin. It is necessary to monitor coagulation parameters in patients receiving ascorbic acid daily at a dose of 5 g or more and adjust the dose of warfarin accordingly.

Increases absorption ethinyl estradiol, tetracycline and penicillins.

Promotes absorption gland and its deposit in restored form.

Amphetamine / dextroamphetamine /benzphetamine

Using ascorbic acid with dextroamphetamine, amphetamine, or benzphetamine may reduce the effects of these drugs. Do not stop using drugs without consulting a doctor.

ascorbic acid and combined oral contraceptives mutually reduce each other's concentration.

At simultaneous application With deferoxamine potentiates its effect and increases iron excretion.

smoking and ethanol accelerate the metabolism of ascorbic acid and reduce its content in the body.

special instructions

In connection with the stimulating effect of ascorbic acid on the synthesis of corticosteroid hormones, it is necessary to monitor adrenal function and blood pressure.

With prolonged use of large doses, inhibition of the function of the insular apparatus of the pancreas is possible, therefore, in the course of treatment, it must be regularly monitored.

Since ascorbic acid increases iron absorption, its use in high doses can be dangerous in patients with hemochromatosis, thalassemia, polycythemia, leukemia, sideroblastic anemia. In patients with high content iron in the body should take ascorbic acid in minimal doses. The use of ascorbic acid in high doses can cause an exacerbation of sickle cell anemia.

Pregnancy and lactation

Use with caution during pregnancy, as high doses of vitamin C more than 1 g per day can cause abortion due to increased estrogen synthesis. Use during pregnancy and lactation after consulting a doctor.

Features of the effect of the drug on the ability to drive vehicle or potentially dangerous mechanisms.

In therapeutic doses, ascorbic acid with glucose does not affect the ability to drive a car or potentially dangerous mechanisms.

Overdose

Symptoms: nausea, vomiting, shortness of breath, decreased blood pressure, arrhythmias, acute left ventricular failure (ALF).

Treatment: gastric lavage, monitoring of kidney function and blood pressure, symptomatic therapy.

Release form and packaging

10 tablets in a contoured non-cell package made of paper with a polymer coating. Boundless non-cell packs with instructions for medical use in the state and Russian languages ​​are placed in a cardboard box (group packaging). The number of instructions must match the number of packages. 50 tablets in polyethylene jars with polypropylene lids. 250 contour packs or 20 cans, together with instructions for medical use in the state and Russian languages, are placed in a cardboard box.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25 °C.

Keep out of the reach of children!

Shelf life

Do not use after the expiration date.

Terms of dispensing from pharmacies

Over the counter

Manufacturer

Eikos-Pharm LLP, Kazakhstan, Almaty region, Ili district, pos. Boralday, 71 junction.

Registration certificate holder

Eikos-Pharm LLP, Kazakhstan

Address of the organization that accepts claims from consumers on the territory of the Republic of Kazakhstan regarding the quality of products (goods), responsible for post-registration monitoring of the safety of the medicinal product

Almaty, st. Nusupbekova, 32

tel: 397 64 29, fax: 250 71 78,

e-mail: [email protected]

Attached files