Component (subunit) vaccines. Vaccine "Pentaxim": what it is from, composition, description of instructions

Appearance in the family small child always associated with a lot of worries and troubles. Your mouth is full of worries - these words fully apply to every young parent. One of these headaches is the issue of vaccinations. To give or not to give, what are the advantages, what are the disadvantages, when it is possible and when it is not possible... One of the vaccinations given to newborn children is the Pentaxim vaccine. It’s worth figuring out what kind of animal it is and how painful it bites.

What is vaccination

In simple terms, an inoculation or vaccine is the introduction of a virus of a particular disease into the body. This is done so that the human body recognizes the substance “thrown” to it as the causative agent of the disease and fights it, thereby developing immunity against this infection. And if the virus enters the inside of a person again, the antibodies present there will recognize it and neutralize it. Thus, the disease is not scary for a vaccinated person, although, of course, in rare cases, he can also be exposed to the infection. But even if this happens, the disease will pass in more mild form and almost unnoticed.

There are several types of vaccines, different in composition - live, inactivated, recombinant and toxoids. The first contains the pathogens themselves, so to speak, alive, the second contains them, but already “killed”, the third contains only parts of cells with bacteria, and the fourth is obtained due to the inactivation of the toxins of the pathogens.

Why are vaccinations needed?

Many today ask a similar question, but the answer to it is the simplest - so as not to get sick. It is thanks to the existence and effect of vaccinations that a large number of diseases have now been eliminated, which did not allow us to live in peace and often caused the death of a huge number of people in past centuries. For example, smallpox - how many people became its victims!

Vaccines also help fight liver and cervical cancer and prevent the development of human papillomavirus. And in general, if the overwhelming majority of the population is vaccinated, then even the unvaccinated (those who have certain contraindications) simply have no one to catch the infection from - therefore, the disease may disappear.

To bet or not to bet

This is another pressing issue that has plagued more than one generation of moms and dads. Many are sure: vaccinations are evil, they are dangerous, and it is because of them that a child can get sick. But if you don’t give your baby a vaccine, then nothing will happen to him. It often comes to the point that even in the maternity hospital, women write a refusal to vaccinate their baby against hepatitis and BCG.

Whether or not to vaccinate your baby is up to each individual parent. Some people believe that a child will not be accepted without vaccination. kindergarten. This is not so - when registering, they will, of course, ask about vaccinations, but if the refusal from them was written officially, in the children's clinic, then the baby will be enrolled in kindergarten, assigning him a certain number. Such numbers are issued to all children without vaccinations - this shows that responsibility for the life and health of the child lies solely with the parents, and not with healthcare. Moreover, at school, all vaccinations are given only with written consent Moms and dads don’t force anyone to persuade them.

By the way, some doctors themselves are of the opinion that it is not worth vaccinating a child before the age of two. It is necessary for the baby to acquire its own immunity, and you should not interfere with it. This practice is widespread in many countries.

Vaccination effectiveness

In order for everything to work as it should, you should adhere to certain simple rules:

1. The required intervals must be observed between vaccinations.
2. You should buy the vaccine immediately before the procedure itself.
3. The procedure can and should only be carried out by a specialist - that is, medical worker.
4. When purchasing the vaccine yourself, you should follow the rules for its storage and transportation.

Vaccine "Pentaxim"

One of the mandatory vaccinations for newborn babies is the vaccine against whooping cough, tetanus and diphtheria - three in one. It is called DPT and is first administered to babies at the age of three months (in the absence of contraindications). This vaccination is Russian production, many people regard it as too tough and heavy for kids. That is why many parents who decide to vaccinate their child turn to the French analogue of DTP - the Pentaxim vaccine. We will not describe here how dangerous each of the above-mentioned diseases is, but what is good about Pentaxim should definitely be told.

The main difference between the imported Pentaxim vaccine and domestic analogue The point is that, although DTP is also a combination vaccine, it includes three vaccines, and the foreign vaccine includes as many as five (more details about the composition of the French vaccine will be discussed below). This vaccination can only be given to healthy children, and according to the rules it is necessary to take urine and blood tests before the procedure (although this is often not done). In addition, there should be no medical withdrawal from the neurologist.

Pentaxim is an acellular vaccine that has been widely used in our country since 2008. Among other things, the Pentaxim vaccine gives a very good immune effect and serious protection for the body, but does not protect against meningitis and pneumonia (for some reason many people believe the opposite).

DTP or Pentaxim?

Both domestic and foreign vaccines have both their supporters and their opponents. Which one is best for a child?

DTP is inexpensive - what is its advantage, in contrast to the more expensive Pentaxim. The DPT vaccine is quite simple, it protects, as mentioned above, from diphtheria, tetanus and whooping cough, the mortality rate of children from which, unfortunately, is extremely high. It is placed three times. If you administer DTP to your baby, you will need to do separate vaccinations against polio and Haemophilius influenza - also several times, then when using Pentaxim the number of injections will be reduced to only four (versus twelve).

What diseases is the Pentaxim vaccine against? From all of the above, which is five different viruses at once. This is the advantage of Pentaxim over DTP. In addition, he wins with his composition. Whooping cough in Pentaxim does not have a shell that can give a negative reaction to the introduction of the vaccine. "Pentaxim" after DTP is well tolerated, on the contrary - poorly.

Both DTP and Pentaxim have their drawbacks. It is believed that in the domestic vaccine they are present in a more pronounced volume. Thus, children should not be injected during illness, with fever, sensitivity to the components of the vaccine, with encephalopathy and allergies.

Composition of the Pentaxim vaccine

So, Pentaxim, as has been repeated many times, is a combined type vaccine that protects against five different serious illnesses. The Pentaxim vaccine contains toxoids against diphtheria, tetanus and whooping cough, Haemophilus influenzae polysaccharide (it is in a separate bottle and mixed with the rest when diluting the drug) and three types of polio virus. Excipients Also present in the vaccine are, for example, formaldehyde and acetic acid.

At what age is vaccination required?

The instructions for the Pentaxim vaccine state that the baby should be given its first dose at the age of three months. The second and third vaccinations are subsequently carried out at four and a half months and six months, and revaccination - after a year. Of course, if there are any contraindications, the timing of the injections will be shifted - a child over one year old can also be vaccinated, if for some reason this has not been done before. However, if a child older than six months is vaccinated, the third vaccination is given without diluting the vial with Haemophilus influenzae. And in the case of a baby older than one year (if he has not been vaccinated before), he receives only the first vaccine against five diseases, and subsequently injections are given to such a child without the introduction of Haemophilus influenzae.

Medical outlet

If a child has any of the following, vaccination should be postponed (or canceled, depending on the pediatrician's recommendation).

1. Increased sensitivity to the drug and/or its components.
2. An allergy that appeared after a previous injection, if the injection was not given for the first time.
3. Fever, illness - infectious or exacerbation of chronic disease.
4. Encephalopathy.
5. Seizures and any other neurological symptoms.
6. Brain damage and/or epilepsy.
7. Hemocoagulation disorder.

Side effects

Any medicine can have side effects in one form or another, and the Pentaxim vaccine is no exception. The vaccine can provoke a fever of more than thirty-eight degrees, rash, convulsions, and allergic reactions. Extremely rare, but drowsiness and lethargy were noted, as well as, on the contrary, irritability, insomnia, headaches and prolonged tears. After the Pentaxim vaccine, the injection site may hurt, it may turn red, and a lump will probably appear there, which will resolve very soon on its own, without the use of any measures. Also called swelling of the injection site as a side effect, this too, however, goes away on its own. However, if Quincke's edema suddenly begins, you should not expect it to disappear - you must urgently call a doctor.

Instructions for use

How to administer the Pentaxim vaccine correctly? Firstly, it is important to know that a single dose is half a milliliter. Secondly, Pentaxim has its own special syringe, which prevents overdose and minimizes pain in the child. According to the instructions for use of the Pentaxim vaccine, it should be administered intramuscularly. Intravenous and subcutaneous administration is strictly prohibited. For little ones they give an injection in the thigh, for older children - in the shoulder. As a rule, babies do not feel pain - only a slight tingling sensation, and therefore do not cry during vaccination and behave calmly.

Concerning simultaneous use“Pentaxima” with other vaccines, it is allowed if these vaccines are from the vaccination calendar (except for BCG). According to the instructions for the Pentaxim vaccine, this vaccination does not affect their ability to develop immunity. However, the pediatrician should be aware of some nuances. For example, what medicine, besides Pentaxim, was or will be given to the baby. Before a child is vaccinated, he must be carefully examined by a doctor to assess the baby’s health. If the doctor finds anything inconsistent with vaccination recommendations, vaccination should be postponed. By the way, if the baby had the disease several weeks before the vaccination (less than a month ago), it is also not recommended to get it.

The Pentaxim vaccine must be stored in the refrigerator for no more than three years. temperature conditions from two to eight degrees above zero. Freezing the drug is strictly prohibited.

Preparing for vaccination

There are simple rules that must be followed before vaccination.

1. Take blood and urine tests.
2. Be examined by a neurologist.
3. When breastfeeding a baby, there is no need to introduce new foods into his diet (and the mother herself should not start eating any new foods).
4. If there were any previous allergic manifestations, then it’s better to drink a couple of days before vaccination antihistamines.
5. A week before vaccination, you should not take any new medications without first consulting your doctor.
6. This may not be useful, but it’s better to have this on hand: you should take care in advance about purchasing antipyretic drugs for your baby (both suppositories and syrup are perfect) - a frequent negative reaction to vaccination can be a temperature above normal.
7. As a rule, children tolerate the procedure well, but in case the child is very afraid or in pain, you need to take his favorite toy with you.

Caring for the graft

After the baby has been injected, it is recommended not to leave the clinic immediately. It is best to stay in it for half an hour - then in the event of an allergy or any other negative reaction, medical assistance will be provided immediately. In addition, if the child is in an excited state, this time is more than enough for him to calm down.

Within three days after the vaccination, it is necessary to measure the baby’s temperature. If she rises higher normal value, you should give your baby any antipyretic - Panadol, for example, or Nurofen. It is also permissible to wipe the child with warm water or very weak vinegar solution, but in no case with vodka. If the antipyretic drug does not help the baby, you need to call a doctor.

On the day of vaccination, you should not bathe your baby, and you should not walk with him. The injection site should not be scratched.

We are talking about this with the head of the department for the prevention of infectious diseases of the Research Institute of Children's Infections of the Federal Medical and Biological Agency of Russia, Dr. medical sciences, Professor Susanna Harit.

Mechanism of mortality reduction

"AiF. Health”: – Susanna Mikhailovna, why is there so much attention to vaccinations today? They've always been made. There was a time, in the 90s, when many parents refused vaccinations. But now this is not the case.

S.H.:– I think we should start with the fact that today in our country it is significantly higher than in Europe. And infants, and children, and adults. National project stipulates that by 2020 we should reach the European level in terms of this indicator. When medical world began to analyze the causes of mortality, it turned out that among the top 10, diseases of the lower respiratory tract and oncology occupied third or fourth place. And when they began to classify these reasons, they discovered that diseases of the lower respiratory tract are mainly pneumonia, where infection plays a leading role. What infection? . And the world has created vaccines against pneumococcus a long time ago. There are vaccines for adults and children. In the USA, for example, it is mandatory to vaccinate people over 60 years of age, since they more often, especially after the flu, suffer from pneumonia, which is severe due to chronic diseases and often cause death.

The same is the main cause of pneumonia, otitis and meningitis in children in the first two to five years of life. And children die from pneumonia mainly in the first years of life.

Another cause of pneumonia in children under 5 years of age is Haemophilus influenzae type B, which causes severe purulent meningitis, that is, inflammation of the membranes of the brain, which can result in deafness and death. Most countries in the world vaccinate children against this infection from 2–3 months. If children do not suffer from these infections, the health and demographic indicators of our population will improve. Currently, our National Calendar against Hemophilus Infection, unfortunately, provides for vaccination only for children at risk.

"AiF. Health”: – So new knowledge about the importance of vaccinations leads to the fact that the medical community has a desire to revise the calendar?

S.H.:-  Certainly. Look, in women one of the leading places in the morbidity structure is occupied by cervical cancer. And now there is a vaccine that can prevent it!

So vaccine prevention is one of the mechanisms for implementing the “Health” national project.

Less than in the third world

"AiF. Health”: – How many vaccinations are now included in our National Calendar?

S.H.:- Let's count. From tuberculosis, hepatitis B, whooping cough, diphtheria, tetanus, polio, measles, mumps, rubella, Haemophilus influenzae type B and influenza. Eleven.

"AiF. Health”: – Is this a lot or a little compared to other countries?

S.H.:– This is small even compared to what WHO recommends for developing countries. They still vaccinate against rotavirus infection, and in our country vaccines against it are not even registered, against the human papillomavirus (HPV), against pneumococcus.

"AiF. Health”: – Are these vaccinations relevant for us? Maybe in our climate there are no such infections?

S.H.:–Rotavirus infection is one of the leading causes of intestinal infections in children around the world. Regardless of the country.

"AiF. Health”: – So we also need these vaccinations?

S.H.:– According to data from some territories (Sverdlovsk region, St. Petersburg), the incidence ranges from 800 to 1000 per 100 thousand children. In general, up to 60% of all intestinal infections in children of the first years of life are rotavirus infections.

"AiF. Health”: – And in developed countries, how many vaccinations are there in national calendars?

S.H.:– In Europe, in addition to what we do, there are vaccinations everywhere against hemophilus influenzae type B, only in 5 countries the prevention of pneumococcal infection is not included in the calendar, in many countries they are vaccinated against HPV, rotavirus, meningococcal infection group C, in a number of countries – against chickenpox, revaccinate adolescents against whooping cough. In the USA, in addition to this, they vaccinate against hepatitis A, meningococcus of four serotypes, not just C, herpes zoster, which affects adults, especially the elderly, and vaccinations against whooping cough are given for the last time at 65 years of age.

Who's next?

"AiF. Health”: – Will our calendar change somehow?

S.H.:-  Certainly. There was a message from the President to the Ministry of Health, which recommended considering a gradual expansion of the calendar; leading experts, the Association of Pediatricians, pediatric infectious disease specialists were involved in resolving this issue, and a proposal was made to include everything in the calendar - the prevention of pneumococcal infection, and vaccination against HPV, and against chickenpox , and against hepatitis A, and additional age-related pertussis revaccinations.

"AiF. Health”: – What is the problem of our lag, money?

S.H.:– Of course, it’s difficult financially to enter everything at once. In order for the Ministry of Health to resolve this issue, there must be a very serious pharmacoeconomic justification. Calculation of costs and savings. Epidemiological data must be provided that shows the extent of disease in the country. Now all these justifications are being prepared.

"AiF. Health”: – Do we already have all the necessary vaccines and are they registered?

S.H.:– Yes, they are registered, except for rotavirus – it is at the registration stage. These are imported vaccines, but now efforts are being made to produce them here, and then they will be cheaper. There is an assumption that by 2015 the production of pneumococcal vaccine for children will be mastered, therefore the Ministry believes that by 2015 the prevention of pneumococcal and HPV infections will be included in the National Calendar.

In one bottle

"AiF. Health”: – Now in our country for the first time a vaccine against 6 infections has been registered at once. What are the advantages of such vaccines? For some reason, many parents believe that mono-vaccines are better.

S.H.:– This point of view has a historical background. It was once believed that you first needed to get one vaccination, then another... There was even such a thing as “gentle immunization.” At that time, they knew little about the immune system and believed that it was “easier” for it. Then, when we began to better understand how the immune system works, it became clear that the immune system does not care how many vaccines you administer: one component or 10 components. The answer will be identical.

There is such a concept in immunology - antigen, that is foreign substance, a piece of microbe. So, the number of antigens in a modern hexavalent vaccine with an acellular pertussis component is 23. And the usual DPT contains a whole-cell killed pertussis microorganism; it alone has 3 thousand antigens. Here's the difference, it's obvious. A vaccine against 6 diseases at once - 23 antigens, a vaccine against three infections - several thousand antigens. At the same time, to form protection against the pathogen, all these thousands of antigens are not needed.

Acellular pertussis vaccine is gentler and does not provide as much adverse reactions, so our manufacturers are now working on creating such vaccines. There is hope that a domestic acellular pertussis vaccine will soon appear and replace our old whole-cell vaccine. And then, based on it, it will also be possible to make a domestic multicomponent one. The question is also how many injections should the child be given: four, five or one? An injection is stressful for the baby, he is in pain and scared.

"AiF. Health”: – Will all vaccines be gradually combined?

S.H.:-  Necessarily. In Europe, a third of countries have already switched to multicomponent vaccines. Our compatriots living in Germany and France, when they come to Russia, are surprised why we don’t have vaccines against several diseases in one syringe. They are already used to them.

One of the most important areas of applied immunology is the creation effective drugs for immunoprophylaxis and immunotherapy of infectious diseases.

Immunotherapy– introduction with medicinal purposes immunobiological preparations (for example, therapeutic vaccines, serums, immunoglobulins, interferons, cytokines).

Immunoprophylaxis – administration of immunobiological drugs to prevent the development of infectious diseases (for example, vaccines, serums).

All drugs used to influence the immune system are known as immunobiological preparations. These include substances of different nature and origin.

^ Types of immunobiological drugs:

1. Preventive and therapeutic drugs of microbial origin (for example, vaccines, bacteriophages, eubiotics, toxoids).

2. Medications (e.g. immunoglobulins, cytokines)

3. Diagnostic immune drugs(eg antisera), as well as diagnostic bacteriophages and allergens.

4. Immunomodulators (various synthetic drugs, biostimulants of natural origin).

Immunobiological drugs may have different action on the human body:

1. Active action– drugs induce the development of immune reactions (for example, vaccine preparations).

2. Passive action - the effects of drugs that are effector products of immunocompetent cells (eg, immunoglobulins, cytokines, serums).

3. Specific action exhibit drugs that provide protection against a specific pathogen (e.g., measles vaccine, tetanus toxoid).

4. Non-specific effects are exerted by drugs that indiscriminately stimulate functions immune system(e.g. immunomodulators, many biostimulants).

Vaccines.

The name “vaccines” was given by L. Pasteur to all vaccination preparations obtained from microorganisms and their products. The first vaccine was received by E. Jenner. It contained a live cowpox virus, identical in antigenic properties to the human variola virus, but low virulent for humans. That. the first vaccine strain was borrowed from nature. The merit of L. Pasteur lies in the development of principles for the targeted production of vaccine strains and the creation of vaccines against rabies and anthrax. He discovered the phenomenon attenuation (weakening) – selection of strains with reduced virulence and preserved immunogenic properties by cultivating them under certain conditions or passage through the body of animals resistant to this infection.

Currently, there is a section of immunoprophylaxis that deals with the development and use of vaccines - vaccinology. Thanks to vaccination, many dangerous epidemic diseases for all humanity have been defeated - smallpox (eradicated), polio, diphtheria (virtually eradicated), measles, whooping cough, tetanus, brucellosis, tularemia, anthrax, tick-borne encephalitis, rabies (epidemic danger has been reduced).

The antigens in vaccine preparations are:

1. whole microbial bodies (live or killed)

2. individual antigens of microorganisms

3. microorganism toxins

4. artificially created antigens of microorganisms

5. antigens obtained by the method genetic engineering.

Classifications of vaccines.

1. By the nature of the antigen.

Bacterial vaccines

Viral vaccines

2.According to cooking methods.

Live vaccines

Inactivated vaccines (killed, non-live)

Molecular (anatoxins)

Genetic engineering

Chemical

3. By the presence of a complete or incomplete set of antigens.

Corpuscular

Component

^ 4. By the ability to develop immunity to one or more pathogens.

Mono-vaccines

Associated vaccines.
Live vaccines– preparations in which as effective start are used:

Attenuated, i.e. weakened (lost their pathogenicity) strains of microorganisms;

So-called divergent strains of non-pathogenic microorganisms that have related antigens to the antigens of pathogenic microorganisms;

Recombinant strains of microorganisms obtained by genetic engineering (vector vaccines).

Immunization with a live vaccine leads to the development of the vaccine process, which occurs in the majority of vaccinated people without visible clinical manifestations. The main advantage of this type of vaccine– a completely preserved set of pathogen antigens, which ensures the development of long-term immunity even after a single immunization. However, there are also a number of disadvantages. The main one is the risk of developing overt infection as a result of reduced attenuation of the vaccine strain (e.g. live polio vaccine in rare cases can cause poliomyelitis up to the development of lesions spinal cord and paralysis).

^ Attenuated vaccines made from microorganisms with reduced pathogenicity, but pronounced immunogenicity. Their introduction into the body simulates an infectious process.

^ Divergent vaccines – microorganisms that are closely related to pathogens of infectious diseases are used as vaccine strains. Antigens of such microorganisms induce an immune response cross-directed against the antigens of the pathogen.

^ Recombinant (vector) vaccines – are created based on the use of non-pathogenic microorganisms with genes for specific antigens of pathogenic microorganisms built into them. As a result of this, a living non-pathogenic recombinant strain introduced into the body produces an antigen of the pathogenic microorganism, which ensures the formation of specific immunity. That. the recombinant strain acts as a vector (conductor) of a specific antigen. As vectors, for example, DNA-containing vaccinia virus, non-pathogenic salmonella are used, into the genome of which the HBs genes - the hepatitis B virus antigen - are introduced, virus antigens tick-borne encephalitis and etc.

^ Corpuscular (whole cell, whole virion) vaccines – contain full set antigens, prepared from killed virulent microorganisms (bacteria or viruses) by heat treatment, or exposure to chemical agents (formalin, acetone). For example, anti-plague (bacterial), anti-rabies (viral).

^ Component (subunit) vaccines – consist of individual antigenic components that can ensure the development of an immune response. To isolate such immunogenic components, various physicochemical methods are used, which is why they are also called chemical vaccines. For example, subunit vaccines against pneumococci (based on capsule polysaccharides), typhoid fever (based on O-, H-, Vi - antigens), anthrax (polysaccharides and capsule polypeptides), influenza (viral neuraminidase and hemagglutinin). To make these vaccines more immunogenic, they are combined with adjuvants (sorbed on aluminum hydroxide).

^ Genetically engineered vaccines contain pathogen antigens obtained using genetic engineering methods and include only highly immunogenic components that contribute to the formation of an immune response.

Ways to create genetically engineered vaccines:

1. Introduction of virulence genes into avirulent or weakly virulent microorganisms (see vector vaccines).

2. Introduction of virulence genes into unrelated microorganisms with subsequent isolation of antigens and their use as an immunogen. For example, for the immunoprophylaxis of hepatitis B, a vaccine consisting of the HBsAg virus has been proposed. It is obtained from yeast cells into which a viral gene (in the form of a plasmid) encoding the synthesis of HBsAg has been introduced. The drug is purified from yeast proteins and used for immunization.

Anatoxins– toxins neutralized by formaldehyde (0.4%) at 37-40 ºС for 4 weeks, completely losing toxicity, but retaining the antigenicity and immunogenicity of toxins and used for the prevention of toxinemic infections (diphtheria, tetanus, botulism, gas gangrene, staphylococcal infections and etc.). The usual source of toxins is industrially cultivated natural producer strains. I produce toxoids in the form of mono- (diphtheria, tetanus, staphylococcal) and associated (diphtheria-tetanus, botulinum trianatoxin) drugs.

Conjugate vaccines are complexes of bacterial polysaccharides and toxins (for example, a combination of Haemophilus influenzae antigens and diphtheria toxoid). Attempts are being made to create mixed acellular vaccines that include toxoids and some other pathogenicity factors, for example, adhesins (for example, acellular pertussis-diphtheria-tetanus vaccine).
Mono-vaccines – vaccines used to create immunity to one pathogen (monovalent drugs).

Associated drugs – to simultaneously create multiple immunity, these drugs combine antigens of several microorganisms (usually killed). The most commonly used are: adsorbed pertussis-diphtheria-tetanus vaccine (DPT vaccine), tetravaccine (vaccine against typhoid fever, paratyphoid A and B, tetanus toxoid), ADS vaccine (diphtheria-tetanus toxoid).
^ Vaccine administration methods.

Vaccine preparations are administered orally, subcutaneously, intradermally, parenterally, intranasally and inhalation. The method of administration determines the properties of the drug. Live vaccines can be administered cutaneously (scarification), intranasally, or orally; toxoids are administered subcutaneously, and non-live corpuscular vaccines are administered parenterally.

Intramuscularly sorbed vaccines (DTP, ADS, ADS-M, HBV, IPV) are administered (after thorough mixing). ^ The upper outer quadrant of the gluteal muscle should not be used, since in 5% of children the nerve trunk passes there, and the buttocks of the infant are poor in muscle, so the vaccine can get into the fatty tissue (risk of slowly resolving granuloma). The injection site is the anterior outer thigh (lateral part of the quadriceps muscle) or, in children over 5-7 years old, the deltoid muscle. The needle is inserted vertically (at an angle of 90°). After the injection, you should pull back the syringe plunger and inject the vaccine only if there is no blood, otherwise the injection should be repeated. Before injection, gather the muscle into a fold with two fingers, increasing the distance to the periosteum. On the thigh, the thickness of the subcutaneous layer in a child up to the age of 18 months is 8 mm (max. 12 mm), and the thickness of the muscle is 9 mm (max. 12 mm), so a needle 22-25 mm long is sufficient. Another method- in children with a thick fat layer - stretch the skin over the injection site, reducing the thickness of the subcutaneous layer; at the same time, the depth of needle insertion is less (up to 16 mm). On the arm, the thickness of the fat layer is only 5-7 mm, and the thickness of the muscle is 6-7 mm. In patients hemophilia intramuscular injection is carried out into the muscles of the forearm, subcutaneous - into the back of the hand or foot, where it is easy to press the injection channel. Subcutaneously unsorbed - live and polysaccharide - vaccines are administered: into the subscapular region, into the outer surface of the shoulder (at the border of the upper and middle third) or into the anterior outer region of the thigh. Intradermal injection (BCG) is carried out into the outer surface of the shoulder, the Mantoux reaction is carried out into the flexor surface of the forearm. OPV is administered by mouth; if a child regurgitates a dose of the vaccine, he is given a second dose; if he regurgitates that too, vaccination is postponed.

^ Observation of vaccinated people lasts 30 minutes, when theoretically possible anaphylactic reaction. Parents should be informed about possible reactions requiring consultation with a doctor. The child is observed by a foster nurse first 3 days after the administration of an inactivated vaccine, on the 5-6th and 10-11th days - after the administration of live vaccines. Information about the vaccination performed is recorded in registration forms, vaccination logs and in the Certificate of Preventive Vaccinations.
According to the degree of need, the following are distinguished: planned (mandatory) vaccination, which is carried out in accordance with the vaccination calendar and vaccination for epidemiological indications, which is carried out to urgently create immunity in persons at risk of developing an infection.

^ CALENDAR OF PREVENTIVE CHIPLES IN UKRAINE

Chips behind the eyelid

1 All newborns are encouraged to chip away, so there is no contraindication. Vaccination is carried out at the 3rd-5th birthday of the child (not earlier than the 48th year after birth). For vaccination of premature infants with body weight ≥ 2000 g it is necessary to introduce a vaccine for the prevention of tuberculosis with a changed antigen (hereinafter referred to as BCG-m).

Splitting for the prevention of tuberculosis should not be carried out on the same day as other splittings or other parenteral manipulations.

Children who have not been born in a hospital canopy are subject to obligatory vaccination for health protection.

If the child is not cleft in the canopy hospital due to medical contraindications, clefting is carried out with the BCG-m vaccine, in other types of clefting it is carried out with the vaccine for the prevention of tuberculosis (hereinafter referred to as BCG).

For children under two months old, splinting for tuberculosis is carried out without a preliminary Mantoux test. After the two-month period before the end of BCG treatment, a Mantoux test should be performed on the child. Splitting is carried out if the test result is negative.

As a method of early detection of tuberculosis, the Mantoux test with 2 tuberculin units of tuberculin is tested for all children from the age of 12 months systematically once a day, regardless of the previous result.

Revaccination against tuberculosis is encouraged in children up to 7 years old with a negative Mantoux test result. Revaccination is carried out with the BCG vaccine.

Due to the fact that prophylactic splitting can affect sensitivity to tuberculin, when conducting tuberculin diagnostics for the eyelid, it is necessary to plan before carrying out prophylactic splitting. For these or other reasons, the Mantoux test should be performed after prophylactic splitting, tuberculin diagnostics should begin no earlier than one month after the splitting.

2 Vaccinations to prevent hepatitis B improve all newborns. To vaccinate children against hepatitis B, the following scheme is used: 0 (first dose) - 1-6 months of the child’s life.

Newborns with a body weight of less than 2000 g, who were born from HBsAg positive mothers, vaccination is carried out obligatory for the population according to the 0-1-2-7 scheme (0 - first life, date of first administration of the vaccine, minimum interval between with first and second chips - 1 month, for other and third chips - 1 month, for third and quarter chips - 5 months).

3 Splitting for the prevention of diphtheria, right and cough are carried out behind the eyelid at 3 months (first splitting), 4 months (other splitting), 5 months (third splitting) and 18 months (fourth splitting).

The interval between the first and the other, the second and the third doses of the vaccine against cough, diphtheria should be at least 1 month. The interval between the third and fourth chips should be no less than 12 months.

To vaccinate children against cough in the first years of life, vaccines with both an acellular (hereinafter referred to as AACDP) and a whole-cell (hereinafter referred to as ACDP) cough component can be used.

A history of cough is not a contraindication before vaccination against this disease.

Vaccination against cough is carried out for children up to 6 years 11 months 29 days.

Revaccination against diphtheria and in 6 patients is carried out with diphtheria-pravtsev toxoid (hereinafter referred to as ADP), in 14 patients and in 18 patients - with diphtheria-pravtsev toxoid with a changed antigen (hereinafter referred to as ADP-M).

First planned revaccination of adults after age and epidemiological indications, which have previously been splitting, should be carried out with ADP-M at intervals of 5 days after the remaining splitting. Further planned revaccinations of adults are carried out with ADP-M at a minimum interval of 10 days after the forward splitting of ADP-M.

4 The inactivated vaccine for the prevention of polio (hereinafter - IPV) is used for the first two doses, and in case of contraindications, before the introduction of the oral polio vaccine (hereinafter - OPV) - for all future doses according to this Calendar.

The OPV vaccine is released for the 3rd-6th period (secondary period - 5 months, 18 months, 6 months and 14 months) for which it is contraindicated before OPV.

The IPV vaccine can be stocked for the 3-6th phase either separately or in the warehouse of combined vaccines.

Children who are in the family with HIV/AIDS infection or persons for whom OPV is contraindicated should be treated with the IPV vaccine.

After splitting OPV, it is necessary to avoid injections, planned operations for 40 days, and cut off contact with people for whom the administration of OPV is contraindicated.

5 Vaccination of children to prevent infection with the Haemophilus influenzae type b stick (hereinafter referred to as the Hib vaccine) can be carried out with monovaccines or combined vaccines that remove the Hib component. In the case of a variant Hib vaccine, it is necessary to give priority to combination vaccines with a Hib component for the primary vaccination.

Splitting to prevent infection with the stick of Haemophilus influenzae type b is carried out according to the scheme for 3-4-18 months.

Vaccination against Hib infection is carried out for children up to 4 years 11 months 29 days. In the elderly, vaccination against Hib infection is carried out only to persons from the risk group up to Chapter 4 of this section.

6 Vaccination for the prevention of measles, mumps and rubella is carried out at 12 months of age. Another chipping - the woman has 6 rocks.

For children who have not been vaccinated against measles, mumps and rubella behind the eyelid at 12 months and at 6 months, vaccination can begin at any age up to 18 months. Every child can take 2 doses with a minimum interval between doses.

You have suffered from illness in the liver, mumps and rubella are not contraindicated until the splitting.

Vaccination against measles, mumps, rubella for people over 18 years of age, who have not removed the chaff behind the eyelid, is given in sections III and IV of this Calendar.

Do not start the vaccination series right away if a dose has been missed, regardless of how many hours have passed. It is necessary to administer doses that are not scheduled, at the required minimum intervals between doses.

^ Contraindications to vaccinations

Vaccinations are allowed healthy people, however, in preventive work, the doctor is often faced with the need to determine contraindications to vaccination in children and adults with various pathological conditions. Pathological conditions that are the basis for permanent exclusion from vaccinations on the basis current contraindications, are rare, their total frequency does not reach 1%. Another group of conditions (for example, acute diseases) requires only a delay in immunization - in these cases the term “withdrawal” should not be used, since the child (or adult) to be vaccinated is actually included in the list of those vaccinated and is being monitored to determine when, when vaccination becomes possible.

Contraindications that require delaying immunization should be differentiated for each drug and approached individually for each vaccine recipient. In this case, there are a number of general approaches: the intervals between any vaccinations with live vaccines should be at least 2 months, and with killed vaccines and toxoids - at least one month. Vaccinations are not carried out during the maximum incubation period for people who have been in contact with the source of infection, except for vaccinations against benthic infection. But, in the event of a threat to the life of a child, quarantine for any disease is not an absolute obstacle to immunization and in every specific case requires individual approach. At acute diseases administration of drugs specific prevention postponed until recovery.

There are no contraindications for emergency prophylaxis of tetanus and vaccinations against rabies, however, here too it is necessary to remember about the choice of drugs for each person vaccinated.

^ False contraindications

Unreasonable exemption from vaccinations using diagnoses such as stable or regressing neurological conditions, asthma, eczema, anemia, birth defects, enlargement of the thymus, long-term treatment antibiotics, steroids, etc. Also, exemptions from vaccinations for children who have had sepsis, hemolytic jaundice, pneumonia, or who have a family history of epilepsy, SIDS, or severe vaccine reactions are not justified. Such references do not indicate the doctor’s care for children, but only his medical illiteracy.

^ Post-vaccination reactions and complications

Post-vaccination reactions. Post-vaccination (vaccination) reaction is a state of the body characterized by a short-term, mostly subjectively assessed, change in the nature of its functioning. Objectively manifested in change functional state systems for ensuring homeostasis, which, as a rule, do not go beyond the physiological norm and are compensated in nature. In some cases, post-vaccination reactions can be considered borderline with a pathological condition. Changes in subjective and objective indicators in such cases go beyond the norm but are short-term (no more than 7 days).

Post-vaccination reactions are divided into local and general. Local ones develop directly at the site of drug administration. With parenteral administration, the intensity of the local reaction is assessed as follows: hyperemia without infiltrate or infiltrate with a diameter of up to 2.5 cm - weak reaction; infiltrate with a diameter of 2.6 - 5.0 cm - medium strength; infiltrate with a diameter of more than 5 cm, or infiltrate in the presence of lymphangitis with lymphadenitis - a strong reaction.

Expressiveness general reaction It is customary to evaluate mainly by the degree of temperature increase, i.e. the reaction is weak - at a temperature of 37-37.5°C, medium - at 37.6-38.5°C, strong at a temperature above 38.5°C. In addition to the degree of temperature increase, other criteria can be used, for example, a decrease blood pressure, vomiting, short-term fainting after the administration of typhoid vaccines, dyspeptic disorders after the use of cholera vaccine, the severity of conjunctivitis, catarrhal phenomena in the nasopharynx, the intensity of the rash after immunization with measles vaccine.

Post-vaccination complications. Post-vaccination complications are painful reactions that differ in the time of onset, strength and quality from the usual ones characteristic of this drug reactions. Pathological processes that occur in the post-vaccination period are divided into:

1) actual post-vaccination complications, the development of which was a direct consequence of the vaccination (anaphylactic shock, post-vaccination encephalitis, etc.);

2) complications associated with violation of aseptic rules during vaccination and inoculation of foreign microorganisms along with the vaccine;

3) exacerbation of chronic diseases and activation of latent infection (tuberculosis, rheumatism, bronchial asthma and etc.);

4) pathological processes associated with intercurrent infection that occurred in the post-vaccination period.

In these cases, the vaccine process can contribute to the severity and complicated course of intercurrent infection (respiratory viral, staphylococcal, meningococcal, etc.). In turn, intercurrent infection can cause a more severe course of the vaccination process.

All cases of complications and unusual reactions that developed after the use of bacterial, viral and serum drugs are subject to special recording. The investigation is organized by the territorial Central State Examination Center, which received an emergency notification from the health care facility. An epidemiologist and a clinician take part in the work of the commission. general profile(generalist or pediatrician), a doctor with a narrow specialization in the complication profile. The report drawn up at the end of the investigation is sent through the authorities to the Ministry of Health.

In order to prevent post-vaccination complications, it is necessary:

Impeccable vaccination technique, primarily strict adherence to asepsis;

Compliance with the established timing of vaccinations;

Identification of contraindications;

Timely implementation of recreational activities;

Use of gentle immunization methods.

The "French" (actually Americans, hiding behind a manufacturing plant in France) are testing their five-component a vaccine that they are not even going to use in such a test version. They simply paid Moscow for this (information taken from the news).

This is a vaccine that consists of five different components in one syringe: , and Haemophilus influenzae type b.

Each component of any vaccination is in itself a shock and stressful effect on the child’s body. And then there are five at once! One can carry on an inconclusive debate on this issue for a long time. Or you can give a simple metaphor: “ What is more harmful: five glasses of vodka in five days or a liter at a time?»

Their website (privivka.ru) (later gradually developed into a website about vaccinations in general) was (at the time of writing this article, September 10, 2009) completely strewn with various articles about vaccines that have nothing to do with the drug at all. Not a word about the actual composition of the vaccine! Some Natalya P. wrote on their forum “ Anti-vaccination hysteria, flooding and advice from non-specialists on this site will be deleted“, she also claims that science has absolutely proven that vaccinations are completely harmless, although many mothers may resist them. And nowhere is it reported who this Natalya P. is, what her last name is, her position, place of work and whether she herself has a medical education. Since 2009, there has already been a lot of news about child deaths. Mentions can be found in the press of other countries: Ukraine, India, Turkey, Poland, the countries of South Africa, the Czech Republic... in general, they gathered all the third world countries + many NATO countries (the same France) and launched massive “tests” on the population, and even for their own money.

Quote about Pentaxim:

Combined pediatric vaccine to protect against 5 dangerous infections- Haemophilus influenzae infection type b (Hib) - starting from 3 months of age.

Immunogenicity corresponds to that with separate administration of vaccines, while ( from the editor: about the consequences of introducing such large quantity infections are kept silent.)

The inactivated polio component eliminates the risk of complications from the live vaccine virus ( from the editor: this is a five-component composition, but here we are talking about only one component)

Hib component provides high level protection against meningitis, pneumonia, otitis caused by this infection in the most early age (from the editor: this Hib component is supplied separately in powder form and the vaccine can be used without it as a four-component vaccine. This is what the manager writes Clinical Center immunoprophylaxis of childhood infections, Professor Mikhail Petrovich Kostinov: “Haemophilus influenzae (Hib) infection is a group of diseases caused by Haemophilus influenzae type b. It spreads through saliva when sneezing and coughing, as well as through toys and household items that children put in their mouths. Haemophilus influenzae can cause pneumonia, acute respiratory infections, bronchitis, sepsis, otitis media, meningitis and other diseases. Unfortunately, on a national scale in Russia they are just beginning to identify and register this infection and, accordingly, to train doctors. It is for this reason that she is relatively little known.” Before instilling the fifth component, ask if there is real threat in your region to get this infection.)

Many are against vaccines in general, but we want to warn against foreign vaccines that are tested on experimental children in Russia, we advertise “miracle vaccines” with all our might and attract doctors to recommend them.

Now let's read vaccine reviews:

We gave our daughter Pentaxin and no problems. Not the slightest hint.

Europe has been on Pentaxim for a long time, I don’t understand why they thought it was being tested on Russian children. They've been doing it for over 10 years now. Two friends’ children in Germany were vaccinated with this vaccine, and in fact they weren’t even offered alternatives!

This alone inclined me in favor of Pentaxim, since they make it the weakest, which means it puts the least burden on the body.

Good afternoon!!! We got vaccinated this Tuesday, November 16, 2010. We did it only, without Haemophilus influenzae + vaccination against hepatitis. A blister of 3 cm in diameter approximately 3 cm in diameter formed at the injection site, the temperature the next day was 36.9-37.5. I won’t tell the child that there was something different. And on the third day a runny nose and sneezing began. In short, we are undergoing treatment now. I am not happy with this vaccination, for some reason I was very worried before getting it, I read a lot about it. The reviews were different, a lot of positive ones. And maybe because it was the first time they did it, there were only positive things about it. No fever, no swelling at the injection site. We wanted to do it, but we didn’t go to pharmacies naked. They say for some reason it disappeared

We did it 2 times with Pentaxim, the first time with hemophilus, the second time without, and the third time we did it with Infanrix.

It was easier to bear - in the evening slight fever, the next day there was a slight fever and that was all. Infanrix+Imovax (from) suffered much worse - three days of fever and swelling at the injection site of Infanrix - the lump lasted a month!!! And this comes with preparation: Viburkol and Zyrtec. And only after donating blood and with the permission of a hematologist.

If I had done as they do in state clinics, immediately after examining the child, then I think they would definitely have been in the hospital after that.

Having done this to my son at 3 months, I will regret it for the rest of my life! Exactly two hours after the vaccination, we started having seizures. I thought I would go crazy while I waited for the ambulance (they arrived in 30 minutes). I've been in the hospital twice already. I understand that this is one case out of a hundred, but we got it! And how many children died from Pentaxim? And this is just what we know from the news! Think, mommies! Health to you and your children!

I gave it to my child. We had a fever for 24 hours. The maximum rose to 38.5.

Before that, like you did, I placed it 3 times, there was no reaction.

The first time they set the temperature rose to 37.5, the second time there was nothing

We got it for the first time yesterday, everything was fine, only the injection site hurt and was swollen..

And in general, we have a complete mess in the vaccination schedule. The baby is often sick. We caught herpes last summer when I was 9 months old, and now it appears on her lips almost every month. We've tried everything to boost our immunity! I don’t know what to do anymore. As soon as a couple of months of our health pass, doctors again begin to persuade us to get vaccinated. We are 2 years old and 5 months old, and we are not finished yet either. And the whole point is that after the 2nd (in the Fatherland) at 5 months we had a temperature of about 40, and my leg hurt very much, it didn’t even allow me to touch it (I couldn’t even pick it up for 2 days, just so as not to move my leg ), cried with her. At the same time, hepatitis was also done, but the leg in which it was done hurt. After that, I didn’t dare to get a single vaccination for almost a whole year, after I got hepatitis separately, everything was fine, a month later in drops, everything was also OK, then I decided to go for it - even the temperature didn’t rise a degree. After that, this fall I got it also, hepatitis, measles, rubella, all separately, and everything was successful. But we give vaccinations between diseases, keeping a “distance,” but sometimes on the 2nd or 3rd day after vaccination the baby fell ill with an acute respiratory infection. And now we need to do revaccination next week and. I wanted to do it, but in 2 hours I read so much (and not only from you) that now I obviously won’t agree to it. Most likely I will do it, but I wouldn’t really want to do it right away with polio.

Purple violet March 3, 2011

We did it yesterday, everything was fine, but today the temperature is below 38. The instructions say that this is possible for 2-3 days, and you need to give an antipyretic. Gave me Nurofen. Previously, there was no reaction to vaccinations - this was done. I worry.

Emma_tyan March 17, 2011

It's not much easier. A - this is a terrible thing. It is scary because out of 100 vaccinated children, 99 children tolerate it normally, and 1 may become disabled and this could be your child. My child and I were in the 18th psychoneurological hospital. I can say that about 30% of children with cerebral palsy received cerebral palsy precisely after. I don't need to read science articles- I saw this with my own eyes - poor children who developed normally before vaccination, and then stopped developing, their legs turned out, they stopped speaking, they had frequent convulsions, etc.

To be honest, I’m not at all against vaccinations, I just think that a vaccine against 5 diseases at once is too much.

Why not give your child ADSM? This vaccine is much safer! There is no that pertussis component. It itself is not as scary as the consequences after being vaccinated against it.

I won't do it.

Hello!!! I'm scared to get vaccinated!!! I vaccinated my boy before he was one year old! I couldn’t even imagine what the consequences would be! At 3 months we were diagnosed with + polomelit! My child was born absolute healthy baby! After vaccination, we did not have a fever because I received an imported vaccine! After 1 day we had a rash all over our bodies! I called the doctor and she said it was not from the vaccine! Then I thought that all the problems were from me since I have a tendency to allergies! And then I gave further vaccinations. I didn’t have the Internet then, my child was covered in worse and worse sores, and the doctors kept repeating that we had atopic dermatitis! And when my child needed to be vaccinated at 1 year and 5 months, already revaccinated, I realized that all the problems were caused by vaccinations! and stopped doing it! Soon all the sores were gone! But immunity has been planted! Please tell us we found a cytomegalovirus infection and we also had an Einstein-bar infection! Can we get a medical exemption from all vaccinations?

Our local reaction is very strong - there was infiltration for up to a month and redness for a week. The first time they thought that the needle just got in unsuccessfully, but the second time it was the same parsley:(. We will wait for Infanrix (search)

I came across information on the Internet that if you are allergic to egg whites and brewer's yeast, you can have a severe allergy to the vaccine...

We had a waiver from vaccinations, at 5 months they gave it, it was tolerated normally without fever (ttt), there was a local reaction - redness, it went away after three days. True, we did the preparation on the doctor’s recommendation and took fenistil drops for 5 days (2 days before, on the day of vaccination and 2 days after). 😉

My 6-month-old daughter has an allergy, and therefore we had a medical emergency. At 4.5 months, our pediatrician said that it would be better for us to go to a paid clinic, supposedly it was just for children with allergies. But there they told us that this vaccine might no longer be available and they suggested and said that it was even better than Infanrix in terms of allergies. In general, we got through the first vaccination wonderfully, the other day we had the second one, and the horror was that literally after 2 hours my daughter started having such a hysteria with crying excitedly and lasted for 1, 5-2 hours, they couldn’t calm her down, her leg was swollen, and not “slight redness around the injection site ", and all top part legs up to the knees. At night the temperature rose to 39. As for the 3rd vaccination, my thoughts are on the run (((((I don’t know what to do(((((

A year ago it was done to my son at the age of 2 years, he tolerated it perfectly, no changes were noticed.

Now my son is 3 years old. Yesterday afternoon there was a revaccination. By evening he became lethargic, began to complain that his leg hurt, began to limp, then generally began to cry and refused to walk. Carried in their arms. I couldn’t step on my left leg, I was roaring in pain. The temperature rose to 37.3. She was given Nurofen at night. This morning I woke up: no temperature, cheerful mood, steps on my feet, walks, but has a limp. So this time we tolerate this vaccine much worse. I hope all the consequences are behind us......

We got vaccinated with Pentaxim the day before yesterday. Well, we reacted to something - temperature and terrible moods 🙁

At 3 months the baby was given a domestic DTP - temperature 38 days, yesterday (5 months) they gave Pentaxim - today 37.4, scary

And we installed it yesterday. We didn’t sleep well at night, I was tossing around and moaning, in the morning the temperature was 37.5 and now it’s 38 already. She gave me suprastin and nurofen. Has anyone had this reaction the day after vaccination?

The first time - (without consequences), then with hemophilus (the leg dragged for 2 days + temperature 38 - 1 day), the third without hemophilus (the leg was very swollen - it turned red, the whims of tearfulness for a week - and did not go away...)

The first vaccination was domestic, it was poorly tolerated, the rate was 39 for 3 days, unbreakable, then 2 times (the rate one evening rose to 37.1), revaccination with Pentaxim, a lump formed at the injection site, resolved after 5 days. temperature was 37.5 for 2 days

Everything went perfectly for us too :) As if nothing had happened. But we installed it without the Haemophilus influenzae component until we decided not to burden the baby with anything extra.

Well, I finally found it! They did it for my baby (a relative works in a hospital - she got it through connections), the child got sick 11 days later acute otitis media. Now I understand - this is a reaction to this Hib component. I treated the little baby with antibiotics, but we still can’t recover. And how do we even understand this? What if this hib component was supposed to protect my baby from otitis media, but he got it? How to understand this, in the end!!!

We prepared with fenistil because we have allergies. They installed it yesterday morning. I vomited at lunchtime. By evening the temperature rose to 38. Dali Nurofen. The child had diarrhea about 6 times. She gave her smecta. I vomited several times at night. I didn't sleep all night. Temperature 37. They didn’t know what to do anymore, so they called an ambulance in the morning. The ambulance prescribed a ton of medications (Enterosgel, Rehydron, Smecta, Linex, Enterofuril) and a diet. Some strange intestinal reaction. They said that the immune system might react like that. If there is still vomiting, then you need to go to the infectious diseases department. It looks like I shouldn’t have been poisoned; I didn’t eat anything like that. I'll try to handle it myself. Tomorrow they definitely told me to call the pediatrician for a consultation.

We are one year and 9 months old. This didn't happen before. There was also a local reaction to, well, fever. Once my leg became very swollen and they took me to Matrekha. But there was no such intestinal reaction. The morning before the vaccination, the child was absolutely healthy and cheerful. Before vaccination, the pediatrician carefully examined him. We were examined at the molecular clinic and vaccinated. I trust this institution.

As a result, we spent a week in the hospital on IVs. Rotovirus caught. And they set it. We didn’t yet know that the child was sick. The doctor explained to us that if it weren’t for the vaccination, the child would have become hairless once and would not have been noticed. And since such a heavy vaccine was given, all the body’s forces were aimed at fighting the vaccine. Still, there are 4 or 5 components. And that’s why the virus was so hard to bear. My advice to mothers: before vaccination, do not take them to the playground, let them not have any contact with the children for two days. Then the vaccination will go well. And then you see how it turned out for us. We didn’t take him to the site before the vaccination. But in the evening, the day before the vaccination, we went out for a ride in the stroller. One girl came up to us and gave us a toy to touch. Apparently they got hooked. A incubation period from 24 hours. So it started for us within a day.

We also received this vaccine for the first time, everything went well, I was only indignant when we arrived and our doctor said: “Didn’t you know that there are no free vaccines, now there is only a fee, if you don’t want to pay, come back in a month, maybe there will be one, maybe there won’t be one", fuck it. It’s very expensive 1400 (we’re not rich, we’ve never bought a vaccine with 1 child), we bought it, we’ll get it again in a month and what, now we’ll have to buy it all the time????????

We had it diagnosed on Thursday, we are 10 months old. We’re doing it for the third time, the last two times everything was perfect, but now the temperature has lasted for 3 days and the leg is swollen, the area near the injection is hard and red, the doctor is sending me to a surgeon on Monday. What is this side effects such???

We had the injection for the 3rd time on Tuesday, the first time everything was fine, this time the injection site was swollen, red and hard, there was no temperature, but I give Nurofen immediately after the vaccination. I tied a cabbage leaf to my leg for 3 days, then the nurse from the clinic advised me to do compresses with dimexide (dilute 1 to 5, on gauze, put polyethylene on top and fix, hold for 1 hour, she told me to do it 5 times), but it started to go away for us, so did not do.

Apparently this is some kind of Pentaxima party, because the nurse said that we are not the only ones.

Girls, the first time we staged it, everything was perfect, as if nothing had been staged. And the other day the second vaccination was postponed just horribly!!! Maybe due to teething (the pediatrician saw that the gums were swollen, but sent me for vaccination). They gave the vaccine in the morning - everything was absolutely fine all day, only there was loose stool once, and at night the T rose to 39, my poor daughter was shaking all over, her arms and legs turned blue, she screamed incessantly for about 40 minutes. It was some kind of nightmare!!! Suppositories (2) of Nurofen came out after 10 minutes with diarrhea. The ambulance was so surprised that they called her, they say, everything is fine, this is how it should be (I’ll hit myself against the wall) I had diarrhea the whole next day (8 times). What I experienced is scary to remember even now. Now I’m actually wondering whether to continue. Someone wrote here that two vaccinations already seem to form immunity. Where does this info come from?

An hour ago I was supposed to go with my child to get a vaccination recommended by an immunologist, it’s good that I looked at reviews about it on the Internet, I’m in a little shock that an hour ago I almost did something stupid. In me, too, like many, two opinions are fighting, now for and then against. Until the child was two and a half years old, she did not give any vaccinations to the child, she constantly evaded them, citing the fact that the child was born eight months old, up to a year they underwent treatment courses at the St. Olga hospital on Udelnaya, posed a threat of cerebral palsy, encephalopathy, pyramidal insufficiency, but strangely enough, the doctors Despite all this, they did not give me a medical exemption from vaccinations, they said that they saw no reason for a medical exemption, only my neighbor, who has nothing to do with medicine, did not advise vaccinations until the age of three, since her daughter, after vaccinations at the age of eight months, fell into a coma and woke up on the eleventh day and now she is already five years old, but the girl is disabled (cerebral palsy) and in a very serious stage, their bitter experience frightened me very much, and to the point of panic, I myself began to protect my child from all these vaccinations, not understanding exactly whether I was doing the right thing I do it, lest I harm my child with my fear, because doctors unanimously insist on vaccinations, and from then on two opinions, for and against, arose in me. But when it came to going to the garden, I slowly gave up and a year ago we started doing it. The pediatrician advised us to get vaccinated with the drug, we did it once, then a month and a half later we did it a second time, and when it was time for the third time we got sick, then again and again, when we came to be discharged, the doctor immediately sent us to get vaccinated (and I read before that after an illness, at least two weeks must pass before vaccination) I left the office and went home without any vaccination, my heart told me that it was not the time yet. In general, now a year has passed since the last vaccination and the doctor is sending us to get a revaccination, saying that those two will be counted. So I want to find out if this is really so. I just decided that since I started getting this vaccination, I should finish it so that those first two injections wouldn’t be wasted. If we now do the third one, a year later, will our vaccination be considered complete or will it give us nothing except a tick on the certificate. does it make sense to do it a third time now?

I will describe our sad experience. The eldest child received all vaccinations as scheduled. The youngest was vaccinated with a delay (the mother's heart felt it). 1 went fine. The 2nd vaccination gave a temperature of 38 for two days. After 3, 14 hours later, the temperature rose to 40, 5, the ambulance brought down the temperature, citing a reaction to the vaccine. The pediatrician who came the next day also stated that “the reaction was within normal limits.” In general, 6 days of hell - an unstoppable temperature of 39-40 (the child was 10 months old at the time). The doctors kept saying it was normal. The lymph node in the neck became inflamed, but this did not bother the doctors. On the 7th day, I simply took the baby and went with him to the hospital myself, fortunately there was a doctor I knew. The baby was examined. Result: emergency surgery - purulent lymphadenitis. They said a couple more hours, the abscess would have burst and the consequences would be unpredictable. I thank God, all the doctors - the operation was performed on time and was successful. But here’s the result - the card in the clinic is clean - no doctor’s calls to the house, no ambulance coming three times, not my visits to the clinic - nothing. Now they require vaccinations in the garden. Tell me how to get official honey now. withdrawal and is it even possible? Thank you.