Furazolidone: instructions for use, analogues and reviews, prices in Russian pharmacies. Furazolidone similar drugs

Furazolidone is an antibacterial agent with antimicrobial activity against Gram-negative and Gram-positive bacteria, Giardia and Trichomonas.

Synthetic derivative of 5-nitrofurforol. The drug is effective in the treatment inflammatory diseases caused by Gram-negative aerobic bacteria. Gram positive aerobic bacteria are less sensitive to it, as well as fungi and protozoa.

Anaerobic pathogens are insensitive to Furazolidone. Microbial resistance develops slowly.

It disrupts the processes of cellular respiration of microorganisms, inhibits the Krebs cycle, and also inhibits other biochemical processes of microorganisms, resulting in the destruction of their shell or cytoplasmic membrane.

As a result of the action of the drug, microorganisms release less toxins, and therefore an improvement in the general condition of the patient is possible even before a pronounced suppression of the growth of microflora.

Unlike many other antimicrobial agents, Furazolidone not only does not inhibit, but even activates immune system organism (increase the complement titer and the ability of leukocytes to phagocytize microorganisms).

After ingestion, it is quickly and almost completely absorbed in the intestine. Therapeutically significant blood concentrations persist for 5 to 6 hours after taking a single dose. Furazolidone penetrates into the cerebrospinal fluid, where its concentration is the same as in the blood.

Indications for use

What is Furazolidone used for? According to the instructions, the drug is prescribed in the following cases:

The drug is taken orally, after meals with large quantity water (except local application in surgery). Treatment should not last more than 10 days.

Standard dosages, according to the instructions for use Furazolidone, depending on the indications:

• With dysentery, paratyphoid and food poisoning - 100-150 mg \ 4 times a day (but not more than 800 mg), for 5-10 days.
• With giardiasis: adults - 100 mg \ 4 times a day, children - 10 mg / kg / day, distributing daily dose for 3-4 doses.
• The highest single dose for adults is 200 mg, the daily dose is 800 mg.

Additionally, it is used to treat burns and wound infections. In these cases, they are used topically in the form of wet-drying dressings, or irrigation with a solution of Furazolidone, in a ratio of 1:25000.

special instructions

During treatment with the drug, you should temporarily exclude from the diet or drastically limit foods - cottage cheese, cream, butter, hard cheese, coffee, strong tea, herring.

In order to prevent the development of polyneuritis, taking Furazolidone tablets should be combined with taking B vitamins.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Furazolidone:

• decreased appetite, up to anorexia, nausea, vomiting;
• allergic reactions — skin rash, hyperemia and itching of the skin, angioedema.

Contraindications

Furazolidone is contraindicated in the following cases:

• severe chronic kidney failure;
• pregnancy and breastfeeding period;
• children under 3 years of age;
• increased individual sensitivity or intolerance to the components of the drug;
• cases of allergic reactions to drugs from the nitrofuran group.

Assign with caution:

• chronic renal failure;
• liver disease, accompanied by impaired organ function;
• diseases of the central nervous system.

The drug is contraindicated during pregnancy. It can be prescribed only for vital necessity, taking into account the expected and the risk to the fetus. Animal studies have shown adverse effect to the fruit.

Overdose

Overdose symptoms are acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis).

There are no specific antidotes.

Furazolidone analogues, price in pharmacies

If necessary, Furazolidone can be replaced with an analogue according to therapeutic effect are the drugs:

1. Nifuroxazide,
2. Entprofuril,
3. Rifaximin,
4. imipenem,
5. Azithromycin,
6. Fluoroquinolone,

When choosing analogues, it is important to understand that the instructions for use of Furazolidone, the price and reviews for drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: Furazolidone 50mg 10 tablets - from 55 to 79 rubles, the cost of a pack of 20 tablets - from 87 to 108 rubles, according to 583 pharmacies.

Store at room temperature in a dry place out of the reach of children. Shelf life - 3 years.

Sale in pharmacies without a prescription.

Furazolidone belongs to antibacterial agents and is used to combat poisoning. Effective for infections genitourinary system, gastrointestinal tract and giardiasis. Unanimously recognized by physicians as a safe and effective drug, Furazolidone is approved for use in the treatment of poisoning in children. different ages. What is the drug and in what cases can children use Furazolidone, we will talk.

Furazolidone is a drug from the group of nitrofurans, which has antibacterial properties

Description of Furazolidone

Furazolidone belongs to the group of nitrofurans that have a devastating effect on life processes pathogenic microbes. The working substance is furazolidone, which gave the name to the agent. In addition, it contains lactose monohydrate, calcium stearate, silicon dioxide, potato starch.

Produced in the form of tablets (pellets) and granules; on the packaging, as a rule, the content of the main substance is indicated. For example, Furazolidone 50 means that 50 mg of the active ingredient is present in one tablet. The drug is inexpensive: one blister of 10 tablets costs about 65 rubles, respectively, a package of two blisters costs 130 rubles.

For babies under 3 years old, it is better to buy the drug in granules, from which the suspension is prepared, even a baby can drink it. In order to know how much water to pour into the package, a measuring spoon is included. Children over 3-5 years old can be given dragees. The remedy is sold without a prescription, but it is not recommended to use it without consulting a doctor.

In what cases is it applied?

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Parents should know exactly when Furazolidone can be used. Full information on this issue is given in the instructions for the drug, but it is better to repeat and remember.

Indications for use:

The use of Furazolidone is allowed for children of any age, but with an exact indication of the problem that it must solve.

Consider when to give medicine in relation to the age of the child:

1. For infants, the drug helps in the treatment of infected burns and wounds. A sterile bandage is moistened with Furazolidone and applied to the affected area.
2. For babies after a year, the medicine is given in the form of a suspension for diarrhea and other disorders. Prepare it like this: take 100 ml of warm boiled water and pour it into a bottle with granules. When the drug dissolves, shake the vial and give it to the child, observing the dosage.
3. For children after 3-5 years, the remedy can be taken in tablets.

Dosage calculations

What you should not do is to resort to the help of medicine yourself. Correct dose and the tactics of treatment should be established by the pediatrician.

The doctor takes into account all factors: whether the baby has chronic ailments what kind of pathology, how severe it is. In addition, when calculating the dose, the weight of the child is taken into account. General recommendation according to the daily dose - 10 mg of the drug per 1 kilogram of weight. These indicators mean that a preschooler at 6 years old, weighing 20 kg, should take 200 mg of Furazolidone during the day, and for a baby at 6 months, 60-70 mg is enough.

Treatment regimen

Doctors have developed rules for taking medication for children and given recommendations on nutrition for the period of treatment with Furazolidone. Parents should remember them well:

• during course treatment, the drug should not be taken for more than 10 days;
• multiplicity of reception per day - 4 times;
• it is necessary to give Furazolidone after meals, drink plenty of water;
• it is necessary to reduce the amount of foods in the child's diet that contain tyramine: smoked meats, canned food (meat and fish), chocolate, kefir, yogurt, cheese, legumes.

A nutritional warning is due to the fact that the active substances of the drug, when interacting with tyramine, provoke negative processes. The child may feel dizzy, his pressure will increase, in some cases, such negligence leads to grave consequences. Be sure to monitor the nutrition of the baby in order to prevent such problems.

Contraindications

The minimum indicator of toxicity of Furazolidone is the main argument that allowed pediatricians to prescribe the drug for rotovirus and other infections, even one year old babies. However, this quality does not negate the presence of contraindications in the medicine.

The drug is not used for:

• terminal stage of chronic renal failure;
• problems with the central nervous system;
• lack of glucose-6-phosphate dehydrogenase;
• individual intolerance to nitrofurans.

Side effects

Prescribed in the instructions for Furazolidone and its side effects, there are few of them, but they are, which means they require an attentive attitude on the part of parents. It is necessary to monitor the child, giving him medicine. We list the main negative consequences:

• allergy, manifested by itching, rash, swelling and redness;
• gastrointestinal upset (vomiting, loss of appetite, nausea);
• neuritis (formed with prolonged use).

Consequences of an overdose

It is difficult to overdose the drug when you comply with the dosage established for it, but if information on this matter is in the instructions, then there have been such cases. Complications with an overdose:

• methemoglobinemia and hemolytic anemia;
• destruction of liver cells (hepatitis in an acute toxic form);
• violation cellular composition blood and the functions of the cells themselves;
• polyneuritis.

What medicines is the drug incompatible with?

If there is a need to use Furazolidone, parents are required to tell the pediatrician what other drugs the baby is taking at this time.

The information is very important, because Furazolidone is not compatible with some agents. Let's list them:

1. Ethanol. Communication with this drug provokes acute intoxication, manifested by vomiting, headache, fever, nausea, problems with heart rhythm, difficulty breathing.
2. Antidepressants and monoamine oxidase inhibitors. If the baby takes medicine with phenylephrine, which narrows blood vessels, simultaneous reception Furazolidone will cause a sharp increase in pressure.
3. Antibiotics of the aminoglycoside group are able to enhance the antimicrobial effect of Furazolidone.
4. Foods and medicines that can alkalize urine. Getting into the body together with Furazolidone, they accelerate the process of drug excretion, reducing its therapeutic effectiveness.

What are the analogues?

Analogues compatible with Furazolidone in structure are not produced. There are remedies similar to it in therapeutic action. Which drug to replace the original appointment, the pediatrician decides, based on the diagnosis and nature of the pathogen.

If antibiotics are not required, the child is given Smecta, with bacterial infection The following substitutes are recommended:

Furazolidone is effective against various infections and has a multilevel effect. Pediatricians note its low toxicity, but it also has contraindications and side effects that lead to serious complications. Obviously, with such characteristics, the drug should not be used alone. The decision on its use should be made by a specialist, a doctor who is able to properly build treatment and avoid negative consequences.

Trade name of the drug:

INN or grouping name:

Dosage form:

Compound:

Description:
Tablets of yellow or greenish-yellow color, flat-cylindrical with a chamfer.

Pharmacotherapeutic group:

ATX code: G01AX06

Pharmacological properties

Pharmacokinetics
Well absorbed in oral administration. Against the backdrop of inflammation meninges in the cerebrospinal fluid, concentrations equal to those in plasma are created. It is rapidly and intensively metabolized mainly in the liver with the formation of a pharmacologically inactive metabolite (amino derivative). It is excreted mainly by the kidneys (65%), small amounts are found in the feces, where therapeutic concentrations are achieved against pathogens of intestinal infections.

Indications for use

Contraindications

Dosage and administration

Side effect

Overdose

Interaction with others medicines Furazolidone in combination with ethanol can lead to the development of disulfiram-like reactions, and therefore, their simultaneous administration is not recommended.
Antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, phenylephedrine, tyramine can cause a sharp increase blood pressure.

special instructions

Release form

Storage conditions

Shelf life

Terms of dispensing from pharmacies

Manufacturer/organization accepting claims
LLC Anzhero-Sudzhensky Chemical-Pharmaceutical Plant.
652473, Russia, Kemerovo region, Anzhero-Sudzhensk, st. Herzen, d. 7,

The analogues of the drug furazolidone are presented, in accordance with medical terminology, called "synonyms" - drugs that are interchangeable in terms of effects on the body, containing one or more of the same active ingredients. When choosing synonyms, consider not only their cost, but also the country of origin and the reputation of the manufacturer.

Description of the drug

List of analogues

Note! The list contains synonyms of Furazolidone, which have a similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from of Eastern Europe: Krka, Gedeon Richter, Actavis, Egis, Lek, Geksal, Teva, Zentiva.

Reviews

Visitor survey results

Two visitors reported effectiveness

Visitor Report on Side Effects

One visitor reported a cost estimate

Two visitors reported frequency of intake per day

Three visitors reported a start date

Visitor report on reception time

Eighteen visitors reported the patient's age

Visitor reviews

Official instructions for use

Instruction
for medical use.drug

Furazolidone

How and from what should the drug "Furazolidone" be used? Instructions for use, price, reviews, analogues of this medication will be described below. We will also tell you about what components are included in this medication, in what form it is produced, whether it can be given to children, and so on.

Composition, packaging, form

What is included in the composition of the considered means "Furazolidone"? Reviews of doctors say that active substance this medication is furazolidone. The drug can be purchased in the form of tablets, which are placed in blisters and cardboard packs, respectively (can be sold in paper blisters).

Pharmacological features of the drug

What is the drug "Furazolidone"? Instructions for use, price, reviews, analogues of the drug are presented in the materials of this article. According to the indicated information, it can be concluded that the agent in question is antiprotozoal and antimicrobial. It has a bacteriostatic effect on many different microbes.

The principle of action of the drug is to disrupt the activity of the enzyme systems of some bacteria. The drug is highly effective against gram-negative rods, gram-positive cocci and protozoa.

Among the causative agents of intestinal infections, the causative agents of typhoid fever, dysentery and paratyphoid fever are most sensitive to this drug. At the same time, their stability develops very slowly.

Pharmacokinetic indicators

What pharmacokinetic properties does the drug "Furazolidone" have? Reviews of experts indicate that when taken orally, it is rather slowly absorbed and inactivated in the intestinal tract.

Only 5% of the drug is excreted from the patient's body with urine (as metabolites or unchanged). In this case, the drug can stain the urine in a brownish color.

Indications for use

For what diseases can the drug "Furazolidone" be prescribed? Instructions, expert reviews indicate the following indications for use:

• dysentery;
• food poisoning;
• paratyphoid;
• giardiasis.

Only the attending physician should prescribe the drug for such diseases. In this case, the doctor must rely on the results medical tests and general state sick.

Contraindications for use

What contraindications should the patient be aware of before using medicine Furazolidone? Instructions for use, reviews of doctors highlight the following prohibitions:

• chronic renal failure in the terminal stage;
• the period of bearing a child;
• deficiency of glucose-6-dehydrogenase;
• lactation time;
• hypersensitivity of a person to a group of nitrofurans;
• babies up to the age of 1.

The drug "Furazolidone": instructions for use

The price, patient reviews of this medication will be described at the very end of the article. As for this section, in it we will describe in detail the methods of taking the medicine and its dosage.

Furazolidone tablets are prescribed to patients only inside. For the treatment of diseases such as dysentery, paratyphoid and food poisoning, adults are prescribed 0.1-0.15 g of the drug after meals four times a day. It is recommended to take the medication for 6-10 days. The duration of treatment depends on the severity and nature of the pathological processes.

In similar doses, the drug in question can be taken in cycles. For example, 3-6 days at intervals of 3-4 days.

It should be especially noted that the drug "Furazolidone" is highly recommended not to use for longer than 10 days.

In the treatment of a disease such as giardiasis, adults are prescribed 0.1 g of the drug four times a day. For children with the same diagnosis, the drug is given depending on body weight (10 mg / kg per day). In this case, the daily dosage must be divided into 3-4 doses.

The maximum amount of the drug per day for adults is 0.8 g, and a single dose is 0.2 g.

Adverse reactions

What kind undesirable consequences can cause the drug "Furazolidone"? Expert reviews indicate that this drug often causes vomiting, decreased appetite and nausea. Also, in some cases, while taking this medication, the patient may develop an allergy.

In order to reduce the appearance and intensity of side effects, it is recommended to take Furazolidone before meals, drinking a fairly large amount warm water. If necessary, the dosage of the drug is reduced, and the patient is prescribed antihistamines and B vitamins.

With pronounced adverse reactions you should completely stop taking the medication.

drug interaction

Is it allowed to take "Furazolidone" simultaneously with other drugs? Reviews of doctors suggest that the remedy in question is a monoamine oxidase inhibitor. Therefore, when using it, it is imperative to observe the same precautions as when using other monoamine oxidase inhibitors.

It should also be noted that tetracyclines and aminoglycosides significantly enhance the antimicrobial properties of the drug "Furazolidone". It also sensitizes the human body to ethanol. In addition, this drug is able to increase the inhibition of hematopoiesis against the background of the joint intake of Ristomycin and Chloramphenicol.

special instructions

What you need to know about the drug "Furazolidone"? For children (reviews about the drug are more positive than negative) and adults, this medication is prescribed in limited quantities and with extreme caution in diseases of the nervous system and chronic renal failure.

In order to prevent neuritis, especially with prolonged use of the drug, it must be combined with B vitamins.

According to experts, Furozolidone tablets have the ability to sensitize the human body to the effects of alcohol. Therefore, this remedy is often used for the treatment chronic alcoholism. Especially often it is prescribed when other drugs are ineffective or there are contraindications to their use.

Before taking the drug, it must be borne in mind that it is an MAO inhibitor. In this regard, patients should observe all the same precautions as when using similar products.

The drug "Furazolidone": price, reviews, analogues

There are many drugs that have the same effect on the human body as Furazolidone. Such drugs include the following means: "Befungin", "Negram", "Finer", "Gepar Compositum", "Bi-tol", "Confizim", "Norbaktin", "Vis-Nol".

Presented analogues antimicrobial drug can be both more expensive than the drug in question, and cheaper. It should be noted that the Furazolidone tablets themselves have a relatively low cost. So, 50 mg of the drug in the amount of 10 pieces can be purchased for only 70-80 Russian rubles. Agree, this price is quite acceptable and affordable for many patients.

As for the reviews, most people talk about the drug "Furazolidone" exclusively with positive side. According to patients, such a remedy is highly effective against many bacteria and microbes. However, for the best therapeutic result doctors recommend taking it in combination with other medicines. To do this, you need to consult a doctor and undergo a medical examination.

Concerning negative feedback, in most cases they are associated with the manifestation of side effects. How to reduce the likelihood of their occurrence was described in detail in the "adverse reactions" section.