Chymotrypsin: instructions for use of powder. Chymotrypsin - official* instructions for use Storage periods and conditions

Russian name

Latin name of the substances Trypsin + Chymotrypsin

Pharmacological group of substances Trypsin + Chymotrypsin

Typical clinical and pharmacological article 1

Pharmaceutical action. Proteolytic combination remedy protein nature. Obtained from the pancreas of a large cattle. When applied locally and externally, it breaks down necrotic tissue and fibrinous formations; dilutes viscous secretions, exudate, blood clots. Hydrolyzes proteins and peptones with the formation of low molecular weight peptides, breaks down bonds formed by aromatic amino acid residues (tyrosine, troptophan, phenylalanine, methionine).

Indications. Suppurative bronchopulmonary diseases (bronchiectasis, lung abscess, atelectasis, exudative pleurisy). Diseases of the ENT organs: purulent sinusitis, purulent otitis (acute, subacute, chronic), eustacheitis with viscous exudate, after tracheostomy to facilitate the removal of thick viscous exudate, chronic rhinitis. Burns, bedsores, trophic ulcers, purulent wounds. In ophthalmology: diseases of the cornea (ulcer, herpetic keratitis); burn of the mucous membrane of the eye, obstruction of the tear ducts, sluggish healing of eyelid skin wounds.

Contraindications. Hypersensitivity, malignant neoplasms, destructive forms of pulmonary tuberculosis, stage II-III CHF, pulmonary emphysema with respiratory failure. Do not inject into bleeding cavities or apply to ulcerated surfaces of malignant tumors.

Carefully. Pleural empyema of tuberculous etiology (resorption of exudate can contribute to the development of bronchopleural fistula).

Dosing. Locally, externally.

For the treatment of purulent wounds and bedsores, sterile napkins moistened with a solution: 25-50 mg of the drug in 10-50 ml of 0.25% procaine solution are applied for a period of 2 to 24 hours (depending on the thickness of the purulent-necrotic masses) on the wound surface. The dressings are changed every 3-5 days.

At thermal burns III Art. applied to the scab thin layer the drug at the rate of 1 g per 100 sq. cm of the wound surface, cover with a bandage moistened with a 0.9% NaCl solution or 0.25% procaine solution; apply a waterproof bandage. The dressing is changed every other day. During each dressing change, easily removable areas of necrotic tissue are removed. For wounds covered with a thick scab, it is cut before applying a bandage.

For suppurative bronchopulmonary diseases use inhalation of 25-30 mg of the drug, diluted in 5 ml of distilled water, 1-3 times a day. The solution can also be administered through a bronchoscope, endotracheal tube, or tracheostomy. Antibiotics that bronchodilate drugs can be added to the solution.

For the treatment of ulcers, corneal burns and keratitis, it is used in the form of eye baths in a solution of 1:500 daily, for 2-3 days, or 2 drops of a 0.25% solution are instilled, 4 times a day, for 1-2 days. Obstruction of the tear ducts and wounds of the skin of the eyelids: wash the tear ducts or irrigate the wounds with a 1% solution. Solutions are prepared ex tempore.

At chronic rhinitis instill or irrigate the nasal cavity with a solution (5 mg in 5 ml of 0.9% NaCl solution) 2-3 times a day.

For chronic purulent otitis complicated by cholesteatoma, after washing the cavity with a 0.9% NaCl solution, instill a 0.5% solution of the drug (diluted by 0.9% NaCl solution), 2-3 times a day for 20-30 minutes.

Side effect. Allergic reactions, increased body temperature to subfebrile, tachycardia.

After inhalation administration: irritation of the mucous membrane of the upper respiratory tract, hoarseness of voice.

In ophthalmology: irritation and swelling of the conjunctiva (in this case it is recommended to reduce the concentration of the solution used).

Special instructions. In the next few hours after inhalation, the patient should carefully cough up sputum or remove it with suction.

Chymotrypsin is a proteolytic enzyme produced by the pancreas of mammals.

IN medical purposes chymotrypsin is used, isolated from the pancreas of animals - cattle.

Release form

It is produced in the form of a powder from which a solution is prepared for external and intramuscular use.

Chymotrypsin will dissolve in water, as well as in sodium chloride solution. Sold in sealed bottles.

pharmachologic effect

Chymotrypsin is a proteolytic drug of protein origin. When administered intramuscularly, the drug has an anti-inflammatory effect.

When used topically, the drug activates the process of breakdown of necrotic tissues, as well as fibrous type formations (blood clots, blood clots). The drug actively dilutes sputum, exudates, and blood clots.

During exposure to the components of the product, hydrolysis of proteins occurs and the process of breakdown of those compounds that formed .

Chymotrypsin actively affects the body in diseases of the respiratory tract, in which viscous sputum is formed.

Pharmacokinetics and pharmacodynamics

No description.

Indications for use

Chymotrypsin is prescribed to patients for the following diseases and conditions:

• in inflammatory-dystrophic form;
• osteomyelitis;
• iridocyclitis, iritis;
• , ;
• cataract extraction.

Contraindications

This drug should not be taken by people who have following states or illness:

• medicine;
• decompensated forms;
• disintegrating malignant tumors;
• bleeding wounds;
• infectious hepatitis;
• hemorrhagic diathesis;
• lungs;
• heart failure;
• respiratory failure.

Side effects

The following negative effects are likely when taking Chymotrypsin:

• burning in the place where the product was applied;
• swelling and irritation of the conjunctiva;
• bleeding from healing areas;
• pain at the injection site;
• slight increase in body temperature.

During administration, substances with a histamine-like effect may be released into the cavities.

Instructions for use of Chymotrypsin (Method and dosage)

The instructions for use of Chymotrypsin stipulate that initially, before use, it is necessary to dilute the product: for this, 0.005 g of powder should be diluted in 0.5-2% novocaine solution or 1-2 ml isotonic solution. The resulting solution should be injected deeply into the gluteal muscle.

Adult patients should receive 0.0025 g once daily. As a rule, the course of treatment includes 6-15 injections. A more detailed treatment regimen should be prescribed by the attending physician individually.

For patients with respiratory diseases, Chymotrypsin is administered intramuscularly once a day at a dose of 5-10 mg. Therapy lasts from 12 to 14 days.

For the purpose of prevention and antibacterial treatment It is practiced to administer pleurally 30 mg once a day.

Patients with thrombophlebitis need to take 10 mg of the drug intramuscularly for ten days.

When treating inflammatory phenomena and infectious diseases of the sensory organs, 1 ml of Chymotrypsin is instilled onto the mucous membranes with the addition of 1% novocaine twice a day.

The use of this medicine locally is carried out as follows: the product is applied to sterile napkins, after which the napkin must be applied to the site of the lesion or to a purulent wound. In this case, Chymotrypsin (20-40 mg) is used, dissolved in 10 ml . Therapy continues for ten days.

To prevent complications after operations, daily intramuscular injection of 5-10 mg of the drug is carried out. You need to start treatment 5 days before surgery, after which the medicine is administered for another 3-4 days.

In the case of purulent sinusitis, a solution of 5-10 mg of medication in 3-5 ml of saline solution should be injected into the maxillary cavity. For patients with otitis media, it is recommended to instill 0.5 - 1 ml of a 0.1% saline solution.

Overdose

Due to the low toxicity of this drug, cases of overdose have not been recorded.

Interaction

If treatment with this drug is carried out simultaneously with the use of iron supplements, the absorption of iron may be reduced.

At the same time, the drug can be used with bronchodilators and.

Terms of sale

Can be purchased at a pharmacy with a prescription.

Storage conditions

The product should be stored in a dry and dark place, in temperature conditions from 0 to 10 degrees.

The finished solution is good for one day, and the temperature should be 2-5 degrees Celsius. Should be kept out of reach of children.

Best before date

Chymotrypsin can be stored for 3 years. After this period, it cannot be used.

Instructions for use:

Chymotrypsin belongs to a group of proteolytic drugs that are obtained from the pancreas of cattle. The drug has anti-inflammatory, antiviral and healing effects.

Chymotrypsin has received widespread use as a drug for the treatment of inflammatory-dystrophic and infectious diseases respiratory tract, blood vessels, eyes and nasopharynx.

Composition and release form

Basics active substance– Chymotrypsin 0.01 g.

Auxiliary components: enzymes of animal origin, aspartic acid, serine.

Chymotrypsin is available in the form of a dry powder of 0.01 g for the preparation of a solution for intramuscular injection and external use.

Pharmacological properties of Chymotrypsin

Chymotrypsin breaks down fibrinous formations, thins blood clots and viscous secretions. During the action of the main components of the drug, proteins are hydrolyzed and compounds formed by amino acids are broken down.

Good reviews Chymotrypsin has both active and effective drug for the treatment of respiratory diseases with the formation of viscous sputum.

When administering the drug to patients with severe tuberculosis, care must be taken and treatment should begin with low doses. And after treatment with antihistamines, a preventive course of their complete removal from the body is required.

For patients managing vehicles, during the course of treatment with Chymotrypsin, caution should be exercised.

Indications for use

Chymotrypsin is prescribed for the treatment and prevention of the following diseases:

• respiratory system– bronchitis, tracheitis, tonsillitis, pneumonia, lung abscess;
• bedsores, purulent abscesses, burns;
• thrombophlebitis;
• diseases of the sensory organs - sinusitis, otitis various types, eustachitis, retinal thrombosis, opacities vitreous eyes of a traumatic and inflammatory nature, cataracts.

Chymotrypsin received positive reviews as a drug high efficiency for the prevention of complications after lung surgery.

Instructions for use of Chymotrypsin

As prescribed by the instructions for Chymotrypsin exact dosage prescribed by the attending physician according to the patient's indications.

For diseases of the respiratory system, Chymotrypsin must be administered intramuscularly once a day, 5-10 mg. The course of treatment lasts 12-14 days. If necessary, a second course of treatment may be prescribed after an interval of 14 days.

According to the instructions Chymotrypsin in postoperative period prescribed to administer 10 mg intramuscularly once a day along with 3 ml of novocaine.

For prevention and purposes antibacterial therapy Chymotrypsin is administered 30 mg 1 time per day pleurally.

For thrombophlebitis, the drug is prescribed to be administered intramuscularly at a dose of 10 mg for 10 days. Repeated courses should not be prescribed.

To treat inflammation and infections of the sensory organs, Chymotrypsin is instilled with the addition of 1% novocaine onto the mucous membranes, 1 ml 2 times a day.

Locally, the drug is applied to sterile napkins and applied to purulent wounds and affected skin, 20-40 mg with 10 ml of procaine solution. The course of treatment is 10 days.

Contraindications

Contraindications to the use of Chymotrypsin are hypersensitivity and intolerance to the components of the drug, open wounds and deep damage to the skin, malignant tumors, tuberculosis, cirrhosis of the liver, renal failure, hepatitis, emphysema, nephritis, pregnancy and period breastfeeding, childhood up to 18 years old.

The drug is prescribed with caution for heart failure and severe illnesses. digestive system and in old age.

Chymotrypsin is contraindicated for use on bleeding cavities and skin with swelling and allergic reactions.

Side effects of Chymotrypsin

Chymotrypsin can cause the following: adverse reactions: tachycardia, swelling and inflammation of the mucous membranes of the sensory organs, conjunctivitis, skin hyperemia, increased body temperature.

With a long course of treatment, symptoms may appear allergic reactions– urticaria, itching and burning, hyperthermia, bronchospasm, skin rash.

Latin name: Chymotrypsin
ATX code: D03BA
Active substance: Chymotrypsin
Manufacturer: Samson-Med, RF
Dispensing from the pharmacy: On prescription
Storage conditions: t 0 - 10 degrees
Best before date: Up to 3 years

Chymotrypsin is a powder that is aimed at combating pathogenic proteins, thereby speeding up the recovery process from diseases of the respiratory system. Contains the active ingredient of the same name.

Indications for use

Chymotrypsin is used for the following disease conditions:

• Inflammatory-dystrophic form of periodontal disease
• Inflammation of the vein wall with the formation of a blood clot
• Inflammation maxillary sinus nose
• Osteomyelitis
• Inflammation of the iris
• Inflammation to different parts ear
• Diseases of the bronchi and trachea
• Cataract extraction.

Composition and release form

The chemical composition of the medicine contains chymotrypsin - the main working component. Additionally, it was necessary to add aspartic acid, enzymes of animal origin and serine.

The main active element is a special proteolytic enzyme produced by the pancreas of mammals.

In medicine, an enzyme obtained from the gland of cattle is used.

Chymotrypsin is a compressed, odorless, tasteless, fine-crystalline, boiling-white powder that is placed in sealed glass ampoules. The latter are placed on plastic transparent blisters of 5 pieces, the package contains 10 doses. Additionally, the box contains instructions for use.

Medicinal properties

Chymotrypsin is a drug that is aimed at breaking down pathogenic proteins. The main element is synthesized from the animal pancreas.

Intramuscular administration provides an anti-inflammatory effect. Local use stimulates the breakdown of necrotic tissue, blood clots and thrombi. The product copes well with phlegm and exudate.

Due to the work of the drug, compounds formed by amino acids are broken down, and proteins are hydrolyzed.

The powder has an active effect on the body in case of respiratory tract ailments that form viscous sputum.

Mode of application

The instructions recommend diluting Chymotrypsin powder in 0.5-2% novocaine or sodium chloride. Injections are given intramuscularly, i.e. in the buttock.

Dosage for adults per day is from 5 to 10 mg. Usually the course is 10-12 days. After this, after a week or 10 days, treatment can be repeated. A specialist will prescribe a detailed dosage and regimen after research and test results.

Additionally, the medication can be used topically on purulent wound surfaces. To do this, use sterile bandages or napkins soaked in a solution of chymotrypsin (25-50g) and procaine (10-50ml 0.25%). Time – 8 hours.

The powder is prohibited for use by expectant mothers and nursing mothers.

Contraindications and precautions

Price: 1000 rub.

The drug should not be taken if the patient has one or more of the following conditions:

• Allergy to the main or additional ingredients of the drug
• Tuberculosis in decompensated form
• Malignant tumors that disintegrate
• Bleeding wounds
• Cirrhosis
• Infectious type of hepatitis
• Hemorrhagic type of diathesis
• Inflammation of the pancreas
• Emphysema
• Failure of the heart or respiratory system.

Attention! Intravenous administration of medication is prohibited

For people suffering from severe tuberculosis, the drug is administered gradually, starting with small doses.

Reception antihistamines requires preventive measures to remove these drugs from the body.

Chymotrypsin may have a negative effect on coordination and brain activity, so people working with complex mechanisms or transport managers must exercise extreme caution.

Side effects, overdose, interactions

Taking drugs can provoke the development of negative effects:

• Burning and pain at the injection site
• Allergies of different types
• Tachycardia
• Swelling and irritation of the conjunctiva
• Opening of bleeding from wounds
• Slight increase in temperature.

Due to low toxicity cases negative influence on the body higher doses drugs were not noted.

Chymotrypsin, like its analogues, can reduce the absorption of iron if the latter are taken in parallel with the drug in question.

Bronchodilators and antibiotics can be taken at the same time as the powder.

Analogs

Samson-Med, Russia

Price: 950 rub.

Trypsin is prescribed for the treatment of diseases of the respiratory system and some eye diseases and wound healing. It is based on trypsin, which is also extracted from the pancreas of cattle. Available in powder form for injection.

Pros:

• Insignificant, but cheaper than Chymotrypsin
• Good effect from therapy.

Minuses:

• Burns when inserted
• Has many side effects.

Chymotrypsin- proteolytic enzyme; catalyzes the breakdown of proteins and peptides. Refers to peptide hydrolases. Together with trypsin participates in the proteolysis of food proteins in small intestine Chymotrypsin preferentially cleaves bonds formed by COOH groups of amino acids having hydrophobic side chains and is characterized by a broader specificity of action than trypsin. Unlike trypsin, X. curdles milk.

Chymotrypsin is produced by exocrine cells pancreas in the form of an inactive proenzyme - chymotrypsinogen, which is secreted in duodenum, where under the influence of trypsin it turns into chymotrypsin. In humans and most mammals, two types of chymotrypsinogen are found - A and B, which differ in their physicochemical properties. During the activation of chymotrypsinogen A, several active forms of chymotrypsin are formed, varying in solubility, crystal shape and size. enzymatic activity. The main form of chymotrypsin is chymotrypsin A, a protein with molecular weight about 25,000. The enzyme is most stable in a slightly acidic environment; in neutral and slightly alkaline environments it undergoes autolysis. The optimum action of chromium is at pH 7.5-8.2.

To determine the activity of chromium, a number of methods have been proposed,

X.'s activity is inhibited by a number of synthetic and natural inhibitors. Protein inhibitors of chromium are present in the blood plasma and tissues, protecting proteins from destruction by this enzyme. Many of them are polyvalent and also inhibit the activity of other proteases (for example, a 2 -macroglobulin, some trypsin inhibitors); a specific inhibitor of Ch. in blood plasma is a 1 -antichymotrypsin.

Chymotrypsin is used as a drug that can selectively break down the proteins of necrotic tissues and formations, and dilute viscous exudates and purulent masses. It has an anti-inflammatory, anti-edematous effect and promotes wound healing. Medications Chemotrypsinogen A is obtained from chymotrypsinogen A, which is isolated from the pancreas of cattle and, after recrystallization, is activated with trypsin. IN medical practice use chymotrypsin A, produced under the name “crystalline chymotrypsin”. This is powder white, highly soluble in water and isotonic sodium chloride solution.

Indications for use,

Release form: hermetically sealed bottles or ampoules containing 0.005 G (5 mg) and 0.01 G (10 mg) crystalline chymotrypsin. Storage in a place protected from light at a temperature not exceeding +10°.