Otrivin nose drops - official * instructions for use. Otrivin (full instructions)

Otrivin is vasoconstrictor used for stuffy nose. It is available in the form of a spray or drops. The main active ingredient is xylometazoline. Once on the mucous membrane, it stimulates adrenoreceptors, as a result, swelling and inflammation are removed. The product is colorless and odorless. The taste of Otrivin is slightly bitter. It is felt when the medicine flows down rear wall nasopharynx.

The main active component of the Otrivin complex is xylometazoline. This substance has a balanced pH, thanks to which patients with sensitive nasal mucosa tolerate Otrivin treatment well.

Additional components include: hypromellose and sorbitol. They additionally moisturize overdried mucous membranes.

The composition of the spray with eucalyptus and menthol also includes eucalyptol and levomenthol. They create a feeling of freshness and have a cooling effect.

If you use the drug in a strictly specified dosage, then it practically does not enter the general bloodstream. local action lasts up to 8 - 10 hours.

Release form Otrivin

The drug is used only locally. For ease of use, different age groups it is produced in the following forms:

• Drops - they are for children (xylometazoline concentration 0.05%) and for adults (with a concentration of 0.1%). The volume of the tube can be 5 or 10 milliliters.
• Nasal spray - it is available in two forms, depending on the concentration (0.05 or 0.1%). The volume of the bottle is 10 milliliters.
• Spray Otrivin with eucalyptus and menthol - it is usually used by adults, since it contains 0.1% xylometazoline. In the produced bottle - 10 milliliters.

Also in pharmacies you can buy an aspirator Otrivin Baby. It is produced in a bottle - a dropper. Volume - 5 ml. Sprays are available for irrigation of the nasal cavity. It can be Otrivin sea and Otrivin sea forte. Both drugs contain sea ​​water and help to disinfect the mucous membranes of the nose.

Otrivin spray is considered the most popular. Thanks to the spray effect, the drug gets even into hard-to-reach places where drops do not penetrate. This allows you to increase the chances of a quick recovery.

When is the drug used?

The instructions for use indicate that the drug can be used in the following cases:

• In time ;
• With allergic rhinitis;
• To improve breathing colds(ARVI);
• During otitis;
• With congestion of the sinuses during diseases of the respiratory tract;
• Before rhinoscopy;
• Before preparing for surgery.

Otrivin drops or spray relieve congestion and make breathing easier. But they cannot be used as the only drug for the treatment of the nose. The tool is used as one of the medicines during complex therapy.

Main contraindications

Otrivin renders therapeutic effect, but the drug has a number of limitations in its use. It cannot be used for:

• Glaucoma;
• arterial hypertension;
• tachycardia;
• If the baby has intolerance to one of the components of Otrivin;
• During atrophic rhinitis;
• With severe atherosclerosis.

Vasoconstrictor drops and spray should not be used if the child has problems with the cardiovascular system or has diabetes.

What are the side effects?

The drug rarely causes unpleasant reactions. The list is listed in Otrivin's instructions for children. Among the consequences may be:

• Dryness of the nasal mucosa;
• Frequent sneezing, burning sensation in the nose;
• Swelling of the nasal mucosa;
• Hypersecretion.

If Otrivin is used for a long time and uncontrollably, this will lead to systemic side effects indicated in the instructions:

• Depressive state - the baby becomes aggressive and irritable;
• Nausea and vomiting;
• The child has tachycardia or arrhythmia, an increase in pressure is possible;
• Blurred vision.

Also long application Otrivin may cause allergic reactions.

Instructions for use for children

The dosage and duration of use is prescribed by the attending physician, but it is usually recommended to use it as follows:

1. Drops with a concentration of xylometazoline 0.05% drip one or two drops once a day if the child is not yet 1 year old.
2. Drops of 0.05% are instilled 1 - 2 drops up to 3 times a day, if the baby's age is from 1 to 6 years. Do not use the drug more than once every 7-10 hours.
3. Drops with an active substance concentration of 0.1% can be used by older children school age. They are used no more than 4 times a day, 1-3 drops in each nasal passage.

The use of Otrivin spray for children is carried out in the following dosage:

1. Babies under 6 years old are given 1 injection, no more than 3 times a day.
2. Children who are already 6 years old are prescribed one injection two to four times a day. But you can not use the spray more than 5 times a day.

Attention! Do not use the drug for more than ten days in a row.

How to store Otrivin

The average storage temperature is from 15 to 20 degrees. It is impossible for the temperature to be higher than 30 degrees or 25 degrees (if we are talking about sprays with menthol and eucalyptus).

The shelf life of Otrivin is 3 years from the date of issue and subject to proper storage. The tool can be bought at any pharmacy, without a doctor's prescription.

Basic analogues

The effect of other drugs is similar to Otrivin. These are the same vasoconstrictor drops in the nose for children or sprays. Their effectiveness is based on xylometazoline.

Analogues include:

• Nazivin;
• Sanorin;
• Tizin;
• Afrin;
• Rinazolin, etc.

How to use Otrivin Baby

How to use the Otrivin baby aspirator

This is a device that helps to remove mucus from the nasal passages of the baby. The device is harmless, it can be thermally processed, unlike electric aspirators.

1. Lay the baby on his back with his head slightly tilted down. Next, take the drops and drip into left nostril child one - two drops of Otrivin.
2. Now lower the nozzle into the same nostril, and take the mouthpiece into your mouth. Draw the mucus into the nozzle, but do it gently, without sudden movements so as not to scare the baby.
3. Replace the nozzle with a new one, and do the same with the other nasal passage. Pre-drop a couple of drops of Otrivin Baby into it.

The procedure is performed 3-4 times a day until all the symptoms of the disease completely disappear. Before use, you should go for a consultation with a children's ENT.

Conclusion

Otrivin for children is a nasal spray or drops. The drug is prescribed for nasal congestion in children and adults. It has only a temporary relief effect, so I use Otrivin in combination with other drugs. Nevertheless, the drug makes breathing easier, as evidenced by numerous reviews. The product should not be used for more than 10 days in a row. Treatment in young children (under 6 years of age) should be carried out under the supervision of the attending physician.

Otrivin is a drug intended for use in ENT practice.

What is the composition and form of release of Otrivin?

The drug is produced in a metered nasal spray, it is represented by a clear solution, at a concentration of 0.05% and 0.1%. The active compound is xylometazoline. The excipients are as follows: sodium dihydrogen phosphate dihydrate, water, sodium hydrogen phosphate dodecahydrate, sodium chloride, disodium edetate, hypromellose, benzalkonium chloride, sorbitol.

Otrivin 0.05% is packaged in 10 ml polyethylene bottles, the container is equipped with a dosing device and a protective cap. Spray 0.1% is available in a container of 15 ml. Shelf life no more than three years.

The next dosage form of Otrivin is represented by transparent nasal drops, where the active substance xylometazoline is present. I will list the auxiliary ingredients: sodium dihydrogen phosphate, sorbitol, sodium hydrogen phosphate dodecahydrate, sodium chloride, disodium edetate, water, benzalkonium chloride, hypromellose.

Drops are placed in vials of ten milliliters, the container is made of polyethylene material, equipped with a dropper cap, in addition, the bottle is equipped with a so-called first opening control system. Sold without a prescription. Implementation is designed for three years from the date of release of the drug.

What is the effect of Otrivin spray / drops?

The vasoconstrictor drug Otrivin is prescribed topically in ENT practice. Kilometazoline, the active compound, has an adrenomimetic effect. The drug narrows blood vessels, localized in the nasal mucosa, relieves redness and eliminates swelling of the nasopharynx, thereby, with rhinitis, the medication makes breathing easier.

The drug has a balanced pH characteristic of the nasal cavity. The composition of the vasoconstrictor contains inactive components, represented by sorbitol and hypromellose, they are considered moisturizers, reduce irritation of the mucosa, and prevent its dryness.

A few minutes after using the spray, therapeutic effect, it lasts approximately twelve hours.

With topical application of the spray, there is practically no absorption of the drug.

What are the indications for the use of the Otrivin medication?

I will list when Otrivin spray (drops / spray) instructions for use allow you to use:

With rhinitis against the background of acute respiratory infections, as well as with allergic form runny nose;

With otitis media;

With pollinosis;

For sinusitis and eustachitis.

In addition, the vasoconstrictor drug Otrivin is used before preparing the patient for diagnostic manipulations that will be performed in the nose.

What are the contraindications for the use of Otrivin?

Spray Otrivin instructions for use does not allow the use in the following cases:

With glaucoma;

With hypertension;

With increased sensitivity to the drug;

With hyperthyroidism;

Spray is contraindicated in tachycardia;

The medicine Otrivin is not prescribed for severe atherosclerosis;

With atrophic rhinitis;

If there is a history of operations on the membranes of the brain.

What is the use and dosage of Otrivin?

Spray Otrivin is usually used by adults, one injection directly into each nasal passage. It is enough to carry out three, four medicinal injections per day.

The dosage form of nasal spray 0.05% is prescribed for young children from infancy up to six years, also one injection, but no more than two times a day. The duration of the drug Otrivin is ten days.

Nasal drops are usually instilled 1-2 drops in children under six years of age no more than twice a day, and adults can be prescribed 2-3 drops up to a maximum of 4 times a day.

Overdose from Otrivin

Otrivin overdose symptoms: increased blood pressure, tachycardia joins, in addition, confusion is characteristic. The patient is prescribed symptomatic therapy.

What are the medicines Otrivin side effects?

Among the local reactions to the use of the drug Otrivin can be noted: irritation of the nasopharyngeal mucosa, dryness of the nose, hypersecretion is observed, a slight burning sensation, tingling, and quite frequent sneezing is also noted.

Systemic reactions to the vasoconstrictor Otrivin: tachycardia, nausea, arrhythmia, insomnia, increased blood pressure, vomiting, headache, allergies, dizziness, blurred vision, and depression.

If systemic or local side effects occur, it is recommended to stop using the vasoconstrictor Otrivin, and it is also important to consult with your doctor.

special instructions

Do not exceed the prescribed dosages of Otrivin spray, which we continue to talk about on this page www..

How to replace Otrivin, what analogs to use?

Xylometazoline, Snoop, Grippostad Rino, Farmazolin - Please leave your comment below! We ask you! We need to know your opinion! Thank you! Thank you!

by application medicinal product for medical applications

Otrivin® (Otrivin®)

Registration number: P N011649/03

Tradename: OTRIVIN®
INN or Grouping name: Xylometazoline
Dosage form: dosed nasal spray [for children]
Compound:
1 ml of the drug contains
Active substance: Xylometazoline Hydrochloride 0.5 mg.
Excipients:
sodium dihydrophosphate dihydrate 5 mg, sodium hydrogen phosphate dodecahydrate 1.7 mg, disodium edetate 0.5 mg, benzalkonium chloride 50% solution 0.1 mg (calculated as benzalkonium chloride 0.05 mg), sorbitol 70% 20 mg, hypromellose-4 thousand. 5 mg, sodium chloride 4 mg, water up to 1 ml.

Description:
Clear, colorless solution, practically odorless.
Pharmacotherapeutic group: anticongestive agent - alpha-adrenergic agonist.
ATX code: R01AA07

Pharmacological properties

Xylometazoline belongs to the group of local vasoconstrictors (decongestants) with a-adrenergic action, causes constriction of the blood vessels of the nasal mucosa, eliminating swelling and hyperemia of the nasopharyngeal mucosa. Xylometazoline also reduces the concomitant hypersecretion of mucus and facilitates the drainage of nasal passages blocked by secretions, and thus improves nasal breathing in nasal congestion.

Otrivin® is well tolerated by patients with sensitive mucous membranes, its effect does not interfere with the separation of mucus. Otrivin® has a balanced pH value characteristic of the nasal cavity. The composition of the drug includes inactive components - sorbitol and hypromellose (methylhydroxypropylcellulose), which are moisturizers. Thus, the moisturizing formula can reduce the symptoms of irritation and dryness of the nasal mucosa that occur with prolonged use of xylometazoline.

In therapeutic concentrations, the drug does not irritate the mucous membrane, does not cause hyperemia. The action occurs 2 minutes after application and lasts for 12 hours.

In vitro studies have shown that xylometazoline inhibits the infectious activity of the human rhinovirus that causes the "cold".

Pharmacokinetics. When applied topically at the recommended dosages, it is practically not absorbed, plasma concentrations are below the detection limit.

Indications for use

Acute respiratory diseases with symptoms of rhinitis (runny nose), acute allergic rhinitis, hay fever, sinusitis, eustachitis, otitis media(to reduce swelling of the mucous membrane of the nasopharynx). Preparation of the patient for diagnostic manipulations in the nasal passages.

Contraindications

Hypersensitivity to xylometazoline and other components of the drug, arterial hypertension, tachycardia, severe atherosclerosis, glaucoma, dry rhinitis or atrophic rhinitis, hyperthyroidism, condition after transsphenoidal hypophysectomy, surgical interventions on the meninges (in history), childhood up to 2 years.

With caution: diabetes mellitus; pheochromocytoma; diseases of the cardiovascular system (including IHD, angina pectoris); prostatic hyperplasia; with increased sensitivity to adrenergic drugs, accompanied by insomnia, dizziness, arrhythmia, tremor, increased blood pressure.

Use during pregnancy and lactation

The drug should not be used during pregnancy. During lactation, the drug should be used only after a thorough assessment of the risk-benefit ratio for mother and baby, under the supervision of a physician. It is not allowed to exceed the recommended dosage.

Dosage and administration

Intranasally.
Children from 2 to 5 years old: 1 injection in each nasal passage 1-3 times a day.
Children from 6 to 11 years old: 1-2 injections in each nasal passage 2-3 times a day.
Should not be used more than 3 times a day.
The drug in children should be used under adult supervision.
It is recommended to carry out the last application just before going to bed.

Side effect

Frequency classification adverse reactions:
Often
(≥ 10); often (≥1 / 100, rarely (≥ 1/10,000, from the side immune system:
Very rare: hypersensitivity reactions angioedema, rash, itching).
From the side nervous system:
Often: headache.
Rarely: insomnia, depression (with prolonged use in high doses).
From the sense organs:
Very rare: impaired visual clarity.
From the side of cardio-vascular system:
Rarely: palpitations, increased blood pressure.
Very rare: tachycardia, arrhythmia.
From the side respiratory system:
Often: irritation and / or dryness of the nasal mucosa, burning, tingling, sneezing, hypersecretion of the mucous membrane of the nasopharynx.
From the side digestive system: Often: nausea.
Rare: vomiting.
Local reactions:
Often: burning at the site of application.
If any of the side effects listed in the instructions worsen, or you notice any other side effects not listed in the instructions, tell your doctor.

Overdose

Xylometazoline, when locally administered in excess of a dose or if accidentally ingested, can cause severe dizziness, increased sweating, a sharp decline body temperature, headache, bradycardia, increased blood pressure, respiratory depression, coma and convulsions. Following an increase in blood pressure, a sharp decrease can be observed.

Appropriate supportive measures should be taken in case of any suspicion of overdose, in some cases prompt symptomatic treatment under the supervision of a physician is indicated. These measures should include monitoring the patient for several hours. In case of severe poisoning with cardiac arrest resuscitation must last at least 1 hour.

Interaction with others medicines

Xylometazoline is contraindicated in patients currently receiving MAO inhibitors or who have received them within the previous 2 weeks.

Simultaneous use tri- or tetracyclic antidepressants and sympathomimetic drugs can lead to an increase in the sympathomimetic effect of xylometazoline, so this combination is recommended to be avoided.

special instructions

It is not recommended to use continuously for more than 10 days.
Recommended doses should not be exceeded, especially in children and the elderly. Prolonged (more than 10 days) or excessive use of the drug can cause a "rebound" effect (medical rhinitis) and / or atrophy of the nasal mucosa.

Impact on ability to drive vehicle and mechanisms

Xylometazoline does not affect the ability to drive or use machines.

Release form

Dosed nasal spray [for children] 0.05%.

10 ml of the drug in a bottle of polyethylene high density, equipped with a pump dispenser with a tip and a protective cap made of polyethylene. The bottle, along with instructions for use, is placed in a cardboard box.

Storage conditions

At a temperature not exceeding 30 ° C, out of the reach of children.

Best before date

3 years. Do not use after the expiration date.

Holiday conditions

Without recipe.

Name and address of the manufacturer

Novartis Consumer Health SA, Switzerland. Address: Rue de Letraz, 1260 Nyon, Switzerland.
Novartis Consumer Health SA, Switzerland.
Route de l'Etraz, 1260 Nyon, Switzerland

Entity, in whose name the registration certificate was issued and the organization accepting claims on the territory of the Russian Federation:

Medication Otrivin is a vasoconstrictor drug used in ENT practice for local use. Otrivin is produced by the Swiss company Novartis, its active ingredient is xylometazoline. The substance has an anticongestive effect, constricts blood vessels and improves nasal breathing. Read the instructions for use of Otrivin.

Composition and form of release

Otrivin is presented in the format of a nasal spray in three forms, there are no other forms of release. Them detailed composition:

Pharmacodynamics and pharmacokinetics

The drug is intended for local use in diseases of the upper respiratory tract. The active substance of the composition, acidometazoline, is an alpha-adrenergic agonist, constricts the blood vessels of the nasal mucosa. The use of the drug does not interfere with the separation of mucus, does not cause sensitivity of the mucosa. Otrivin has a balanced pH level that matches the acidity level of the nasal cavity.

The inactive components of sorbitol and hypromellose are moisturizers, relieve irritation and dryness, which inevitably appear with prolonged use of xylometazoline. Therapeutic doses of the drug do not cause hyperemia. The action of the remedy begins in a few minutes, lasts for 12 hours. Active ingredients composition are practically not absorbed, have such low plasma concentrations that they are not determined modern methods analysis. In this regard, data on the pharmacokinetics of the spray are not presented in the instructions.

Indications for use

The instructions for use of the drug indicate its indications. These include:

• acute respiratory diseases occurring against the background of rhinitis;
• hay fever;
• acute allergic rhinitis;
• sinusitis;
• rhinoconjunctivitis;
• eustachitis;
• otitis media, proceeding with swelling of the mucous membrane of the nasopharynx;
• preparing patients for diagnostic studies in the nasal passages.

Method of application and dosage

Instructions for use Otrivin for sprays differ slightly. Both forms of release of the drug are used intranasally. Spray with a concentration of 0.05% is suitable for use by children, 0.1% - by adults, the dosage depends on the type of disease, age. There are restrictions on the long-term use of drugs. It is worth considering these recommendations in order to avoid the manifestation of side effects.

Children's spray Otrivin

According to the instructions, Otrivin children's spray can be used for children aged two to five years, 1 injection into each nasal passage up to three times a day. Patients 6-11 years old can spray 1-2 times in each nostril 2-3 times a day. It is undesirable to use the spray for more than 10 days at a time, this can lead to addiction, atrophy of the mucous membrane and a decrease in the effectiveness of the product.

Spray Otrivin

According to the instructions, Otrivin spray is sprayed into the nasal passages. Dosage for children from 12 years and adults - 1 injection 3 times a day. The recommended duration of treatment is 3-5 days. It is not recommended to use the remedy more than three times a day, the last time you need to use the medicine immediately before bedtime.

special instructions

1. The use of xylometazoline does not cause a decrease in the rate of reactions, so it can be used in the management of transport.
2. Do not use the spray for more than 10 days in a row - this causes a rebound effect, medical rhinitis or atrophy of the nasal mucosa.
3. The drug does not affect the course of the infection.

During pregnancy

During childbearing, the drug can be used only on the basis of an assessment and study of the ratio of benefit to the mother and risk to the fetus. If the doctor allows the use of Otrivin, then the dosage must be observed and not exceed maximum doses. According to the instructions, a regular spray (without menthol) can be prescribed to pregnant women under strict control.

Otrivin while breastfeeding

If during lactation (breastfeeding) a woman has a need to use a medication, then doctors can prescribe it after the ratio of risks and if the benefit to the mother exceeds potential threats for a baby. According to the instructions, a regular Otrivin can be prescribed to a nursing woman (without the addition of menthol and eucalyptus oil).

Otrivin for children

Otrivin spray is not indicated for children under 2 years of age, at this age drops are a suitable form. There is a line of Otrivin baby products intended for use from infancy. Adult supervision is required during drug therapy in children under six years of age. All 1% dosage forms given to children after the age of 12. Up to 11 years of age, it is recommended to use a children's spray, it is important to carefully follow the recommended dosages.

drug interaction

According to the instructions, the use of xylometazoline is contraindicated in patients receiving monoamine oxidase inhibitors or β-blockers at the current time or less than two weeks ago. Simultaneous reception of tricyclic or tetracyclic antidepressants, sympathomimetics and Otrivin can lead to an increase in the sympathomimetic effect, so the combination is best avoided.

Side effects

During the use of Otrivin, side effects may occur. The instruction highlights the following:

• irritation, dryness of the mucous membrane, burning, tingling, swelling, sneezing, mucus hypersecretion;
• nausea, vomiting;
• tachycardia, palpitations, arrhythmia, increased pressure;
• headache, dizziness, depression, insomnia;
• allergy;
• blurred vision;
• angioedema, itching, rash, swelling.

Overdose

Symptoms of an overdose of Otrivin are increased side effects - increased pressure, increased heart rate, dizziness, increased sweating. A person's body temperature may drop sharply, and blood pressure may rise. Complications of exceeding the dose or prolonged use of the drug are confusion, coma, convulsions, respiratory depression.

Following an increase in blood pressure, it can drop sharply. According to the instructions, you can eliminate the symptoms of an overdose symptomatic treatment. It is advisable to consult a doctor to monitor the patient and take appropriate measures. In severe poisoning, the heart may stop, in which case resuscitation last at least an hour.

Contraindications

Otrivin is prescribed with caution when diabetes, cardiovascular diseases hypersensitivity to adrenergic drugs, high blood pressure, insomnia, tremor, cardiac arrhythmia, dizziness.