ACC: instructions for use, contraindications, indications, side effects, dosage for children, syrup, granules, effervescent tablets. ACC - stops coughing and cleanses bronchi

Probably every second person in modern world at least once had bronchitis, tracheitis or other infectious diseases, accompanied persistent cough and viscous sputum.

Among the many drugs for coughs and for removing phlegm, ACC in the form of effervescent tablets. The subject of this article is the indications, mechanism of action, composition of ACC, instructions for use of effervescent tablets.

In contact with

Composition ACC 100 mg

1 tablet this drug contains one hundred milligrams active component acetylcysteine. Each dragee also contains additional components, including: sodium bicarbonate, mannitol, blackberry flavor, sorbitol, anhydrous sodium carbonate, anhydrous lactose and others. As for the form of production, ACC 100 is produced in 10 or 20 tablets in one package. Manufacturer - Germany.

Mechanism of action

The drug has the same principle of action as other similar drugs.

The medication contains acetylcysteine, which has the necessary effect on some properties of sputum, which, in turn, contributes to its dilution and exit from the human body. This effect is achieved by reducing its viscosity.

Also, the drug retains its qualities and shows adequate result in the presence of purulent sputum in the body.

ACC has an antioxidant effect, which protects body cells from unwanted oxidation.

Concerning chronic diseases, then it is recommended to take the medicine regularly for prevention purposes. This will help avoid severe consequences during an exacerbation of the disease.

The substances included in the ACC effervescent tablets quickly dissolve in the body. The maximum concentration in the blood of the active substance occurs within two to three hours after taking the medicine.

Indications for treatment

According to the instructions for use, the medication is prescribed for various diseases respiratory organs, especially if such ailments are accompanied by viscous, unpleasant sputum. Among such diseases are the following:

• bronchiolitis and others.

There are also a number of contraindications. Therefore, before taking the medicine, you should consult your doctor and read in detail the recommendations specified in the instructions for use of ACC effervescent tablets.

Despite the fact that the drug in question is easy to use, consultation with a doctor is necessary, since only a specialist has full knowledge and practical experience in the treatment of bronchopulmonary diseases.

Instructions for use of effervescent tablets

Before using ACC effervescent tablets, patients should know how to take the medicine. By following the doctor's recommendations and instructions for use, you will soon forget about coughing and sputum formation.

How to drink?

The method of using ACC effervescent tablets is as follows: the medicine must be taken every day after meals throughout the entire course of treatment. To take the medicine, the tablet is dissolved in water. You should not leave this solution for a long time; it is recommended to drink the medicine immediately after preparing the solution.

What water to dissolve in?

You can often hear the question of what water to dissolve ACC effervescent tablets in. To dissolve the tablet, it is recommended to use a simple hot water(half or whole glass).

When using the drug, you must strictly follow the instructions for use and the doctor's instructions. The dosage must be strictly observed. In most cases, doctors recommend drinking 200 mg of acetylcysteine ​​2-3 times a day. It is also possible single dose immediately 600 mg per day. The medicine is taken immediately after meals.

In case of overdose the following may occur: side effects: nausea, diarrhea, vomiting. Patients suffering from stomach ulcers must be treated with caution, especially if the medicine is taken in combination with other drugs (you can find out the interaction of ACC with other drugs in the instructions for use of the drug).

Before drinking ACC effervescent tablets, it is recommended to consult a specialist. You will find instructions for using the ACC drug in the medication package.

How long can I take it?

The duration of treatment is prescribed by the doctor. According to the instructions for use for uncomplicated diseases, the treatment period lasts 5–7 days. With more difficult cases the course of treatment can last up to 2 weeks or more.

Children's effervescent ACC tablets also have an effective effect on the treatment of a growing organism. If it can be given to infants, then the drug in the form of effervescent tablets is recommended for children at least two years old.

Regarding the dosage of the drug (100 mg), you must remember the following:

1. Children from two to five years old need to take one tablet two to three times a day. The medicine dissolves in warm water. The amount of water required is half a glass.
2. Doctors recommend that children over six years old take one tablet 3 times a day. But there is another dosage at this age - 2 tablets 2 times a day.
3. Children over 14 years of age should follow the following dosage: 2 tablets 2-3 times daily throughout the course of treatment.

ACC effervescent tablets for children should be taken after meals.

After dissolution, the drug does not lose its properties for two hours, but the instructions for use recommend using it immediately after preparation.

Despite the fact that children generally tolerate the effects of the drug well, there are still a number of side effects. The most common of them: hives, rash, itching, diarrhea, vomiting, painful sensations in the abdominal area. Basically, side effects occur due to violation of the dosage specified in the instructions for use. On currently no life-threatening effects were identified in case of overdose. But, be that as it may, you should not neglect the baby’s health even if any unpleasant symptoms You must immediately make an appointment with your doctor.

The drug should be stored out of the reach of children and at a temperature not exceeding 25 degrees. Also, do not forget to read the instructions for use in detail. ACC effervescent tablets for children.

What kind of reviews does the drug receive?

Feedback from patients after taking ACC confirms that the medicine helps remove phlegm well and is also effective for various diseases of the respiratory system.

Thus, many patients note the excellent effect of the drug on sputum formation even in severe stages of influenza. On the other side, negative reviews caused by incompatibility of the drug with antibiotics. Patients are also satisfied with the price and sale of the medicine without a prescription.

Many reviews can also be found from parents who gave their children ACC for children. Effervescent tablets, as a rule, were first prescribed by a pediatrician for lingering cough. In their reviews of children's ACC, parents focus on the rapid liquefaction and removal of mucus due to the action of the medicine. From their words we can conclude that children like the taste of medicines and are also attracted to the bubbles when the tablets dissolve in water. Therefore, children calmly, without tears, drink the fizzy drink. Many parents indicate that the effect of the medicine is noticeable the very next day. Parents like that the medicine is available without a prescription. The price is also reasonable.

Speaking of shortcomings, you can find negative reviews concerning the occurrence allergic reaction on Excipients, present in ACC effervescent tablets.

ACC 200 is prescribed to both adults and children suffering from diseases respiratory tract. The composition of ACC200 effervescent tablets is absolutely identical composition of the ACC 100. Just like in ACC 100 mg, the active component of ACC 200 is acetylcysteine. But in ACC 200 the presence of this component is 200 milligrams. The drug also contains other auxiliary ingredients.

It is necessary to take ACC 200 after first consulting with a doctor, or after thoroughly reading the recommendations contained in the instructions for use, strictly following the dosage.

In terms of its pharmaceutical qualities, ACC Long is no different from the drugs described above. Since the concentration of the active substance in the drug is greater than that of other ACC medications, it must be taken with greater caution.

Usually the medicine is prescribed to people over 14 years of age. This drug is not recommended for children.

There are a number of restrictions that must be taken into account when taking the medication:

1. The drug should not be taken by people suffering from organ diseases digestive tract: sharp forms gastritis, stomach ulcer and others.
2. The medication should be taken with caution by people who are sick bronchial asthma.
3. According to the instructions for use, taking the drug during pregnancy is permitted only in cases where the benefit of the drug is higher than the risk.

If treatment with this medication is necessary, lactation period you should stop feeding the baby breast milk.

Useful video

Useful information about cough treatment can be found in the following video:

Conclusion

1. ACC in the form of effervescent tablets are truly effective means for removing mucus for both adults and children.
2. It is used for a wide variety of respiratory diseases. Thousands of patient reviews testify to the effectiveness of the drug.
3. Before reception of ACC You should consult a specialist and also read the instructions for use of the medication in detail.

ACC 200 (acetylcysteine) is an expectorant drug for multinational pharmaceutical company Sandoz. His active substance acetylcysteine ​​is one of the most well-studied and effective mucolytics (medicines that thin mucus and facilitate its removal from the lungs). One of the advantages of acetylcysteine ​​over other mucolytic agents is the presence of antioxidant activity in this substance. It is the closest relative of glutathione - one of the key links antioxidant protection, which has a protective effect on the respiratory tract and inactivates aggressive free radicals. It is also worth noting the antitoxic potential medicine. Pathogenic bacteria tend to produce toxins that disrupt tissue pH and contribute to the development of inflammation. The release of toxins entails oxidative stress, which reduces the concentration of sulfhydryl groups in cells. Acetylcysteine ​​provides its thiol groups, thereby protecting tissues from oxidative damage and neutralizing toxins. In this regard, acetylcysteine ​​is rightfully considered one of the most universal remedies detoxification. Moreover: it is often used as an antidote for poisoning with various pharmacological substances and poisons. Acetylcysteine ​​also prevents the settling of pathogenic bacteria on the mucous membrane of the respiratory tract.

ACC 200 is well absorbed from the gastrointestinal tract. Rapidly undergoes metabolic transformations in the liver. Metabolites of the drug are pharmacologically active. The peak concentration of the active component in the blood plasma is observed 1-3 hours after oral administration. The half-life is approximately 1 hour. ACC 200 is indicated for diseases of the respiratory tract accompanied by the production of thick pathological secretion tracheobronchial tree, including inflammation of the mucous membrane of the lungs and bronchi, spasmodic bronchitis, inflammation of the mucous membrane of the trachea, larynx, nonspecific inflammation lung tissue with the formation of purulent-necrotic cavities, bronchial asthma, cystic fibrosis, inflammation of the sinuses, acute inflammation middle ear. Optimal time taking the drug - after meals. Additional fluid intake increases the mucolytic potential of the drug. For short-term colds, the duration of the medication course is 5-7 days. If pathological process is chronic in nature, pharmacotherapy continues for a longer period of time until the desired effect of treatment is achieved. Persons suffering from bronchial asthma should be prescribed the drug with the condition of mandatory monitoring of bronchial patency. IN evening time(after 18:00) and before bedtime ACC 200 is not recommended.

Pharmacology

Mucolytic drug. Acetylcysteine ​​is a derivative of the amino acid cysteine. Has a mucolytic effect, facilitates the discharge of sputum due to its direct effect on rheological properties sputum. The action is due to the ability to break the disulfide bonds of mucopolysaccharide chains and cause depolymerization of sputum mucoproteins, which leads to a decrease in sputum viscosity. The drug remains active in the presence of purulent sputum.

It has an antioxidant effect due to the ability of its reactive sulfhydryl groups (SH groups) to bind to oxidative radicals and thus neutralize them.

In addition, acetylcysteine ​​promotes the synthesis of glutathione, important component antioxidant system and chemical detoxification of the body. The antioxidant effect of acetylcysteine ​​increases the protection of cells from the damaging effects of free radical oxidation, which is characteristic of an intense inflammatory reaction.

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis.

Pharmacokinetics

Suction and distribution

Absorption is high. Bioavailability when taken orally is 10%, which is due to the pronounced “first pass” effect through the liver. The time to reach Cmax in blood plasma is 1-3 hours.

Binding to blood plasma proteins - 50%. Penetrates through the placental barrier. There are no data on the ability of acetylcysteine ​​to penetrate the BBB and be excreted in breast milk.

Metabolism and excretion

Rapidly metabolized in the liver to form a pharmacologically active metabolite - cysteine, as well as diacetylcysteine, cystine and mixed disulfides.

Excreted by the kidneys in the form of inactive metabolites (inorganic sulfates, diacetylcysteine). T 1/2 is about 1 hour.

Pharmacokinetics in special clinical situations

Impaired liver function leads to an extension of T1/2 to 8 hours.

Release form

Effervescent tablets white, round, flat-cylindrical, with a notch on one side, with the smell of blackberries; there may be a slight sulfuric odor; the reconstituted solution is colorless transparent with the smell of blackberries; There may be a slight sulfuric odor.

Excipients: lemon acid anhydrous - 558.5 mg, sodium bicarbonate - 200 mg, sodium carbonate anhydrous - 100 mg, mannitol - 60 mg, lactose anhydrous - 70 mg, ascorbic acid- 25 mg, sodium saccharinate - 6 mg, sodium citrate - 0.5 mg, blackberry flavor "B" - 20 mg.

20 pcs. - plastic tubes (1) - cardboard packs.
20 pcs. - aluminum tubes (1) - cardboard packs.

Dosage

The drug is taken orally after meals. Tablets should be taken immediately after dissolution, in exceptional cases you can leave it ready solution for 2 hours. Additional fluid intake enhances the mucolytic effect of the drug.

For cystic fibrosis, children over 6 years of age are recommended to take 2 tablets. (ACC ® 100) or 1 tablet. (ACC ® 200) 3 times/day, which corresponds to 600 mg of acetylcysteine ​​per day. Children aged 2 to 6 years - 1 tablet. (ACC ® 100) or 1/2 tab. (ACC ® 200) 4 times/day, which corresponds to 400 mg of acetylcysteine ​​per day.

For short-term colds Duration of treatment is 5-7 days. At chronic bronchitis and cystic fibrosis, the drug should be used for a longer period of time to prevent infections.

Overdose

Symptoms: in case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn, and nausea are observed.

Treatment: symptomatic therapy.

Interaction

At simultaneous use acetylcysteine ​​and antitussives due to suppression cough reflex Sputum stagnation may occur.

With the simultaneous use of acetylcysteine ​​and oral antibiotics (penicillins, tetracyclines, cephalosporins, etc.), the latter may interact with the thiol group of acetylcysteine, which can lead to a decrease in antibacterial activity. Therefore, the interval between taking antibiotics and acetylcysteine ​​should be at least 2 hours (except for cefixime and loracarbef).

Concomitant use with vasodilators and nitroglycerin may lead to an enhanced vasodilator effect.

Side effects

According to WHO unwanted effects classified according to their frequency of development as follows: very common (≥1/10), common (≥1/100,<1/10), нечасто (≥1/1000, <1/100), редко (≥1/10 000, <1/1000) и очень редко (<10 000), частота неизвестна (частоту возникновения нельзя определить на основании имеющихся данных).

Allergic reactions: uncommon - skin itching, rash, exanthema, urticaria, angioedema; very rarely - anaphylactic reactions up to shock, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).

From the respiratory system: rarely - shortness of breath, bronchospasm (mainly in patients with bronchial hyperreactivity in bronchial asthma).

From the cardiovascular system: infrequently - decreased blood pressure, tachycardia.

From the digestive system: uncommon - stomatitis, abdominal pain, nausea, vomiting, diarrhea, heartburn, dyspepsia.

From the organ of hearing: infrequently - tinnitus.

Other: infrequently - headache, fever; in isolated cases - the development of bleeding as a manifestation of a hypersensitivity reaction, a decrease in platelet aggregation.

Indications

• diseases of the respiratory system, accompanied by the formation of viscous, difficult to separate sputum (acute and chronic bronchitis, obstructive bronchitis, tracheitis, laryngotracheitis, pneumonia, lung abscess, bronchiectasis, bronchial asthma, COPD, bronchiolitis, cystic fibrosis);
• acute and chronic sinusitis;
• Otitis media

Contraindications

• peptic ulcer of the stomach and duodenum in the acute phase;
• hemoptysis;
• pulmonary hemorrhage;
• pregnancy;
• lactation period (breastfeeding);
• children under 14 years of age (ACC ® Long);
• children under 2 years of age (ACC ® 100 and ACC ® 200);
• lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
• hypersensitivity to the components of the drug.

The drug should be used with caution in patients with a history of gastric and duodenal ulcers; for bronchial asthma, obstructive bronchitis; liver and/or kidney failure; histamine intolerance (long-term use of the drug should be avoided, since acetylcysteine ​​affects the metabolism of histamine and can lead to signs of intolerance, such as headache, vasomotor rhinitis, itching); varicose veins of the esophagus; diseases of the adrenal glands; arterial hypertension.

Features of application

Use during pregnancy and breastfeeding

Due to insufficient data, the use of the drug during pregnancy is contraindicated.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Use for liver dysfunction

Use for renal impairment

Use in children

The use of the drug is contraindicated in children under 14 years of age (for ACC ® Long), in children under 2 years of age (for ACC ® 100 and ACC ® 200).

special instructions

For bronchial asthma and obstructive bronchitis, acetylcysteine ​​should be prescribed with caution under systematic monitoring of bronchial patency.

Severe allergic reactions such as Stevens-Johnson syndrome and Lyell's syndrome have been very rarely reported with the use of acetylcysteine. If changes in the skin and mucous membranes occur, the patient should immediately stop taking the drug and consult a doctor.

When dissolving the drug, it is necessary to use glass containers and avoid contact with metals, rubber, oxygen, and easily oxidized substances.

You should not take the drug immediately before bedtime (the preferred time of administration is before 18.00).

1 effervescent tablet ACC ® 100 and ACC ® 200 corresponds to 0.006 XE, 1 effervescent tablet ACC ® Long - 0.001 XE.

There is no need for special precautions when disposing of unused ACC ® effervescent tablets.

Impact on the ability to drive vehicles and operate machinery

There is no data on the negative effect of the drug on the ability to drive vehicles and machines when used in recommended doses.

ACC (Acetylcysteine) is a drug with an expectorant and mucolytic effect, which is prescribed to liquefy viscous bronchial secretions in diseases of the respiratory system that occur with the formation of thick, difficult-to-clear sputum.

In this article we will look at why doctors prescribe ACC, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used ACC can be read in the comments.

Composition and release form

The active substance of ACC is acetylcysteine. The following types of the drug are produced:

1. Effervescent tablets ACC 100, ACC 200 and ACC Long, containing 100 mg, 200 mg and 600 mg of acetylcysteine, respectively;
2. Granules for the preparation of a solution for oral administration ACC, one package contains 100 or 200 mg of acetylcysteine ​​- granules with the smell of orange, 200 or 600 mg of the active substance - granules with the smell of lemon and honey;
3. Orange granules for the preparation of syrup for oral administration of ACC. 5 ml of finished syrup contains 100 mg of acetylcysteine.
4. Solution for intramuscular and intravenous administration ACC Inject, 1 ml of which contains 300 mg of acetylcysteine.

Clinical and pharmacological group: mucolytic drug.

What does Azts help with?

The main indications for use are:

• acute or chronic sinusitis;
• respiratory disease;
• acute and chronic, as well as obstructive bronchitis;
• pneumonia;
• tracheitis;
• lung abscess;
• bronchial asthma;
• Otitis media

pharmachologic effect

The active substance is acetylcysteine, a derivative of cysteine ​​(amino acid). It has a mucolytic, expectorant effect due to the rupture of bisulfide bonds of sputum mucopolysaccharides. This depolymerizes mucoproteins and increases the viscosity of bronchial secretions.

As a result, mucociliary clearance increases and sputum discharge improves. Acetylcysteine ​​has an antioxidant and pneumoprotective effect, which is associated with the binding properties of sulfhydryl groups. It is an antidote for acute poisoning with aldehydes, paracetamol and phenols (the detoxifying effect is possible due to increased production of glutathione).

Instructions for use

The tablet should be dissolved in water (100 ml) and taken immediately after preparation. In exceptional cases, it is permissible to store the solution for a maximum of 2 hours. Take after meals, with additional water.

• Children aged 2 to 5 years are recommended to take the drug 1 tablet. (ACC 100) or 1/2 tab. (ACC 200) 2-3 times/day, which corresponds to 200-300 mg of acetylcysteine ​​per day.
• Children aged 6 to 14 years are recommended to take 1 tablet. (ACC 100) 3 times/day, or 2 tablets. (ACC 100) or 1 tablet. (ACC 200) 2 times/day, which corresponds to 300-400 mg of acetylcysteine ​​per day.
• For adults and adolescents over 14 years of age, it is recommended to prescribe the drug 200 mg 2-3 times/day (ACC 100 or ACC 200), which corresponds to 400-600 mg of acetylcysteine ​​per day, or 600 mg (ACC Long) 1 time/day.

For short-term colds, the duration of use is 5-7 days. For chronic bronchitis and cystic fibrosis, the drug should be used for a longer period of time to prevent infections.

Contraindications

The drug should not be used in the following cases:

• hypersensitivity to acetylcysteine ​​or to any other ingredients of the medicine;
• exacerbation of peptic ulcer;
• pulmonary bleeding;
• pregnancy and breastfeeding;
• glucose-galactose malabsorption;
• hemoptysis;
• lactase deficiency, lactose intolerance;
• child's age up to 2 years.

Side effects

ACCs are generally well tolerated; when taken orally in the form of a solution, a number of side effects may develop, which include:

• From the cardiovascular system - tachycardia (increased heart rate), arterial hypotension (decreased systemic blood pressure).
• From the digestive system - nausea, sometimes vomiting, heartburn, stool disorder in the form of diarrhea (diarrhea).
• From the central nervous system - headache, tinnitus,
• Allergic reactions are rare and severity may vary. They manifest themselves in the form of a rash on the skin, itching, and urticaria (a rash and swelling of the skin that looks like a nettle burn). In extremely rare cases, there may be a reaction from the bronchi in the form of their spasm, reminiscent of an attack of bronchial asthma.

In very severe allergic reactions, anaphylactic shock develops with the development of multiple organ failure against the background of a progressive decrease in systemic blood pressure.

In case of an erroneous or intentional overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.

Pregnancy and lactation

Due to insufficient data, the use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Analogs

Medicines analogous to ACC - ACC Long, Fluimucil, Acetylcysteine, Acetal, Acestad, Acestin, etc. Only a specialist should choose the optimal drug.

Most diseases are always accompanied by a cough, so it is understandable that there is a desire to get rid of it faster. The range of anti-influenza and expectorant drugs is wide. How to make the right choice? Not every medication is suitable for treating dry or wet cough. Likewise, ACC cannot always be used.

ACC - indications for use

The medicine ass is a mucolytic, expectorant and detoxifying agent prescribed for severe coughs in children and adults. This drug is capable of not only thinning mucus, but also effectively removing it from the lungs and bronchi, relieving inflammation, and improving the functioning of the body’s secretomotor functions. The ACC instructions state that it can be used if you have the following health conditions:

• acute or chronic bronchiolitis and bronchitis;
• asthma;
• pulmonary eczema;
• tuberculosis;
• otitis media;

Even this is not all the possibilities of the ACC. Due to its medicinal properties, the drug is often used for cystic fibrosis, a hereditary disease caused by a gene mutation. In addition, it is often prescribed for the treatment of mild or prolonged inflammatory processes of the nasopharynx: tracheitis, acute rhinitis, nasopharyngitis, sinusitis, which are accompanied by the accumulation of large amounts of purulent mucus.

For what cough is ACC prescribed?

If you already have a package of the product in your house, then before going to the pharmacy, you can independently study for which cough you drink ACC. However, complex medical terms and phrases will not be understandable to everyone. Doctors recommend taking the medicine for a wet, productive cough - when excess viscous or too thick sputum accumulates in the bronchi.

ACC – at what age can it be given to children?

Many young mothers ask: is it possible to give ACC to children and at what age? To which experienced pediatricians answer with confidence: not only is it possible, but it is necessary. The main thing is to do it correctly:

• A child from 2 years to 6 years old can only be given ACC 100 mg, which is available as a powder.
• Starting from 7 years of age, treatment with ACC 200 mg is allowed. This medicine can be found in granules.
• ACC 600 is available for children 14 years of age and older. Unlike other medications, this type of medication is effective for 24 hours.
• As a syrup, the medicine can be given to infants, but only under the supervision of a pediatrician.

Method of using ACC

For convenience, many pharmaceutical companies began to produce medicine in several forms: granules, for example, with orange flavor, instant tablets, syrup. Each form has its own doses and limits on how to take ACC:

• It is extremely rare that the solution is prescribed for inhalation. If the nebulizer used for the procedure is equipped with a distribution valve, then you need to use 6 ml of a 10% powder solution. If there is no such supplement, doctors recommend taking a 20% solution at the rate of 2-5 ml per 1 liter of water.
• For bronchoscopy, severe rhinitis, and sinusitis, the use of ACC intratracheally is allowed. To clean the bronchi and sinuses, use a 5-10% solution. The diluted liquid must be dripped into the nose and ears in a volume of up to 300 mg per day.
• When using the parenteral method, ACC is administered intramuscularly or intravenously. In the latter case, the ampoule must be diluted with sodium chloride or dextrose in proportions of 1 to 1.

ACC-long - instructions for use

The ACC product marked long differs from ordinary tablets or powder in that its effect lasts not 5-7 hours, but the whole day. The medicine is produced in the form of large effervescent tablets and is intended for oral administration, 1 tablet 1 time per day, unless otherwise recommended by a doctor. Additionally, along with the medicine, you need to drink up to one and a half liters of liquid, which enhances the mucolytic effect.

How to breed ACC Long:

1. Pour clean, chilled boiled water into a glass and place a tablet at the bottom.
2. Wait until the effervescent effect wears off and the capsule dissolves completely.
3. Once dissolved, drink the solution immediately.
4. Sometimes before drinking ACC, the diluted drink can be left for several hours.

ACC powder - instructions for use

ACC powder (see photo below) is used in the following doses:

• adolescents over 14 years of age and adults are prescribed up to 600 mg of acetylcysteine, the dose is divided into 1-3 approaches;
• it is recommended to give a child under 14 years of age the same dose of the drug, but divided into several doses per day;
• Children under 6 years old can be given 200-400 mg of powder per day.

Both adults and children should drink ACC powder after meals, and the composition from the bag must be properly prepared. What water to dissolve ACC in depends on your preferences, but remember: the best result will be achieved if you dilute the medicine with half a glass of hot water. However, baby granules with orange flavor can be dissolved in lukewarm, boiled water.

ACC effervescent tablets - instructions for use

Acetylcysteine ​​effervescent tablets are diluted with water using the same system as regular powder. The dose of the drug, in the absence of other doctor’s recommendations, is:

• for cold infectious diseases that occur in a mild form, adults - 1 tablet ACC 200 2-3 times a day, duration of administration - 5-7 days;
• for chronic cough, bronchitis or cystic fibrosis, the medicine is taken for a longer period, and its dose for adults is 2 capsules of ACC 100 three times a day.

ACC syrup for children - instructions

Sweet ACC syrup is prescribed to children aged two years and older when diagnosing mild colds or chronic bronchitis. The medicine is taken orally for 5 days, immediately after meals. The dosage of syrup is chosen by the attending physician. If no recommendations have been received from the pediatrician, then the guide will be ACC - the official instructions for use from the manufacturer, which states that you can take the medicine:

• adolescents: 10 ml 3 times/day;
• if the child is from 6 to 14 years old, then 5 ml 3 times a day;
• for children 5 years old, the dose of the medicine is 5 ml 2 times a day.

Remove the baby syrup from the bottle using a measuring syringe. The device comes complete with the medicine. Instructions for using the syringe are as follows:

1. Press the bottle cap and turn it clockwise until it clicks.
2. Remove the cap from the syringe, insert the hole into the neck and press the syringe until it stops.
3. Turn the bottle upside down, pull the handle of the syringe towards you, measuring the required dose of syrup.
4. If bubbles appear inside the syringe, lower the plunger slightly.
5. Slowly pour the syrup into the child's mouth and allow the child to swallow the medicine. Children should stand or sit while taking the drug.
6. After use, the syringe should be washed without soap.

Analog of ACC

If you are looking for a cheap analogue of ACC cough medicine, pay attention to the following medicines:

• , country of origin – Russia. It contains the same active ingredient and belongs to the category of mucolytic expectorants. Its price is about 40-50 rubles.
• Fluimucil, country of origin – Italy. Designed to eliminate the first signs of a cold and cough, but can be used to ease the discharge of viscous secretions from the nose. Its composition consists of 600 mg of acetylcysteine, citric acid, sorbitol and flavorings. The price of the drug is about 300 rubles.
• , country of origin – Germany. It is produced as a syrup based on another active substance – ambroxol hydrochloride. The medicine helps to cope with a protracted, poorly expectorated cough, removes mucus from the bronchi, and softens the respiratory tract. Its price ranges from 200 to 300 rubles.

Price of ACC for cough

The form of release not only contributed to the freedom of choice of the buyer, but also significantly influenced how much ACC costs in pharmacies. More often, its price is very reasonable, which makes the medicine accessible to every social class of the population. However, in different cities and pharmacies, prices for medicine may vary slightly. The average cost of the drug is:

• baby syrup – price up to 350 rubles;
• granular ACC - up to 200 rubles;
• powder – 130-250 rubles;
• orange and honey flavored powder – price from 250 rub.

ACC - contraindications

Contraindications to application of ACC are:

• individual intolerance to the active substance;
• hypersensitivity to additional components of the drug;
• illness during pregnancy, during lactation, excluding artificial feeding;
• ulcer of the duodenum and stomach;
• liver failure;
• history of pulmonary hemorrhage.

In addition, the medicine should not be combined with other cough syrups, bronchodilators and antibiotics that contain codeine and inhibit expectorant reflexes. Those who have previously been diagnosed with venous enlargement of the veins, diseases of the adrenal glands or abnormalities in the functioning of the endocrine system should take the medicine with caution. It is not advisable to take the drug together with alcohol.

Side effects of ACC

Overdose symptoms and side effects of ACC appear as:

• allergic reactions: skin itching, urticaria, dermatitis, laryngeal edema, anaphylactic shock;
• deterioration of health: muscle weakness, drowsiness, ringing in the ears, rapid heartbeat, migraine;
• bowel dysfunction: severe diarrhea;
• indigestion: nausea, heartburn, gag reflex after taking pills.

Video: ACC annotation

ACC - reviews

Anton, 54 years old

I suffered from cough for a long time. I can’t say that he was dry, but the phlegm still didn’t come out. I decided to go to the hospital and the doctor advised me to try ACC Long in effervescent tablets. I took the course as stated in the instructions for the medicine - 5 days. The cough has not gone away at all, but breathing has become much easier, and phlegm is already coming out of the bronchi.

Anastasia, 32 years old

At the beginning of treatment for a wet, persistent cough, a friend advised me to try ACC powder. When I came to the pharmacy, at first I was confused because of the price of the medicine. It cost somewhere around 130 rubles, which is very strange and inexpensive compared to its analogues. I decided to try it anyway and was not mistaken, the cold went away in 3 days, and my breathing returned to normal.

Update: October 2018

ACC (Acetylcysteine) is a drug with an expectorant and mucolytic effect, which is prescribed to liquefy viscous bronchial secretions in diseases of the respiratory system that occur with the formation of thick, difficult-to-clear sputum.

The history of the invention of the drug occurred in the middle of the last century. It was then that Professor Ferrari, who worked at the Italian pharmaceutical company Zambon, discovered the similarity of acetylcysteine ​​with the protein cysteine, which has the ability to break apart mucopolysaccharide molecules that make up bronchopulmonary secretions. The first drug based on acetylcysteine ​​was called Fluimucil.

Pharmgroup: Mucolytic drug.

Composition, physical and chemical properties, price

ACC is available in the form of tablets (effervescent, soluble), granules and powder for oral use with different dosages of the active substance. Another dosage form is a solution for injection (intravenous and intramuscular).

pharmachologic effect

The mucolytic effect of the drug is provided by the active substance acetylcysteine, which is a derivative of cysteine ​​(amino acid). The acetylcysteine ​​molecule has sulfhydryl groups in its structure, which contributes to the disruption of disulfide bonds of mucopolysaccharides in the composition of sputum, which ensure the viscosity of the secretion. As a result, the sputum softens and is more easily separated from the walls of the bronchi.

The drug has a direct effect on the thickness and rheological properties of sputum, maintaining proper activity even with purulent impurities in the bronchial secretion. With the prophylactic use of acetylcysteine, patients with cystic fibrosis and chronic bronchitis note a decrease in the number and severity of exacerbations.

Another effect of acetylcysteine ​​is an antioxidant pneumoprotective effect, which is realized by binding and neutralizing chemical radicals with sulfhydryl groups. The drug accelerates the synthesis of glutathione, a factor of intracellular protection from a number of cytotoxic substances and oxidative toxins of internal and external origin, which allows the use of ACC in case of paracetamol overdose.

Pharmacokinetics

It is quickly and completely absorbed, undergoing metabolism in the liver. During metabolic reactions, pharmacologically active cysteine ​​and a number of other mixed disulfides are formed. Bioavailability is only about 10%. The maximum concentration is achieved in the blood 1-3 hours after administration. The connection with flame proteins reaches 50%. Acetylcysteine ​​is excreted by the kidneys as inactive metabolites. The very rapid half-life of about 1 hour is explained by the biotransformation of the substance in the liver. With liver dysfunction, this period increases to 8 hours.

Indications for use

Diseases of the respiratory system in which difficult to separate, viscous sputum is formed:

• laryngotracheitis;
• bronchitis (acute and chronic);
• bronchiectasis;
• pneumonia;
• obstructive bronchitis;
• lung abscesses;
• bronchiolitis;
• bronchial asthma;
• cystic fibrosis.

Sinusitis (chronic and acute).
Otitis media.

Contraindications to taking ACC

• Exacerbation of peptic ulcer and duodenum;
• Pulmonary hemorrhage, hemoptysis;
• Pregnancy and lactation, ACC is prohibited during pregnancy at any stage;
• Individual intolerance;

The instructions for use of ACC for children indicate that treatment is possible strictly according to medical prescription; the following is contraindicated:

• Children under 2 years of age (except for granules for preparing the drug in a bottle and injections).
• Children under 6 years of age (200 mg granules);
• Children under 14 years of age (600 mg granules).

Prescribed with caution to people with pathological dilation of the veins in the esophagus, at risk of bleeding from the lungs, bronchial asthma, insufficiency of liver and kidney function.

Dosage

Effervescent tablets ACC 100 and 200 mg

The tablet should be dissolved in water (100 ml) and taken immediately after preparation. In exceptional cases, it is permissible to store the solution for a maximum of 2 hours. Take after meals, with additional water.

• Children 2-5 years: One tablet 100 mg or half a tablet 200 mg three times or twice a day (200-300 mg per day).
• Children 6-14 years old: One 100 mg tablet or half a 200 mg tablet three times a day. 2nd regimen: two tablets of 100 mg or one tablet of 200 mg twice a day (300-400 mg per day).
• Adolescents from 14 years old and adults: one tablet 200 mg twice or thrice a day (400-600 mg per day).

In cases of cystic fibrosis, the dose and regimen are different.

• Children 2-6 liters: one 100 mg tablet or half a 200 mg tablet four times a day (200 mg per day).
• Children over 6 years of age: two tablets of 100 mg or one tablet of 200 mg three times a day (600 mg per day).

For patients weighing more than 30 kg, a daily dose of 800 mg is prescribed, evenly distributed over doses.

Granules

The instructions for use of ACC powder indicate the method of preparing the dosage form. Half a sachet or a sachet is dissolved in juice, chilled tea or water and the composition is drunk after meals. To obtain syrup, add drinking water to the bottle up to the mark and shake.

• Children under 2 liters: 50 mg (half a scoop) two or three times a day (100-150 mg per day). Strictly as prescribed by the doctor!
• Children 2-5 liters: One measuring spoon (100 mg) 2-3 times a day (200-300 mg per day).
• Children 6-14 liters: One scoop (100 mg) three times a day (300-400 mg per day).
• Adolescents over 14 years of age and adults: Two scoops (200 mg) two to three times daily (400-600 mg per day).

The dosage regimen for cystic fibrosis is similar to tablets.

Syrup

• The syrup is taken after meals, measuring out the proper amount with a syringe or glass. 10 ml of syrup = half a glass or 2 full syringes. It should be taken with water to increase the mucolytic effect.
• Children 2-5 years old: 5 ml of syrup 2-3 times a day (200-300 mg per day);
• Children 6-14 years old: 5 ml of syrup 3 times a day or 10 ml twice a day (300-400 mg per day);
• Children over 14 years old, adults: 10 ml of syrup 2-3 times a day (400-600 mg per day).

For cystic fibrosis:

• Children 2-6 years old: 5 ml of syrup 4 times a day (400 mg per day);
• Children over 6 years old: 10 ml of syrup 3 times a day (600 mg per day).

Injection

Intended for intravenous or intramuscular administration only in a hospital setting.

• IM: injected deep into the muscle. IV: diluted with 0.9% NaCl in a 1:1 ratio, slow administration.
• Children 1-6 liters: 10 mg of solution per 1 kg of body weight.
• Children 6-14 years old: 150 mg (one and a half ml) 1 or 2 times per day.
• Children over 14 years old and adults: 300 mg (3 ml) 1-2 times a day.

Duration of reception. Short-term colds: 5-7 days. More severe illnesses – for a long time, as prescribed by a doctor.

Side effects when taking ACC

• CNS: rarely – noise in the head, headache.
• Digestive tract: diarrhea, stomatitis, vomiting, nausea, heartburn.
• CVS: drop in blood pressure, tachycardia.
• Allergies: bronchospasm, which is possible with hyperreactivity of the bronchial system, urticaria and skin rash.
• Occasionally, pulmonary hemorrhage may develop in people with hypersensitivity to the drug.

special instructions

• The drug should be diluted only in glass containers. Upon contact with metals, sulfides are formed.
• Patients with asthma and obstructive bronchitis should monitor bronchial patency.
• If any side effects develop, stop taking the drug.
• Patients with diabetes mellitus should take into account the glucose content: in 100 mg of ACC - 0.006 XE.
• Does not affect the ability to drive a car or operate complex machinery.
• Prescribe with caution for kidney and liver pathologies.

Drug interactions

• It is not recommended to combine acetylcysteine ​​and cough suppressants, as this is dangerous by suppressing the cough reflex and stagnation of sputum.
• When used simultaneously with nitroglycerin, the vasodilating effect of the latter is enhanced.
• ACC reduces the adsorption of penicillins, cephalosporins and tetracycline, so antibiotics are prescribed 2 hours after taking the mucolytic.

Analogs

Vicks Active (140-280 rubles)	Fluimucil (150-250 rubles)	Acetylcysteine	Rinofluimucil (nasal) 250 rub.