Aluminum hydroxide magnesium carbonate gel magnesium hydroxide. Dosage for adults and children

Perhaps each of us is familiar with uncomfortable sensations in the stomach and intestines. In everyday life, we eat the wrong foods, our diet is completely unbalanced, and it often happens that we choose fast food as a snack. All this affects the state gastrointestinal tract. Apart from malnutrition, affect the gastrointestinal tract stressful situations, Lifestyle, bad habits. Many of us with discomfort in the stomach or intestines take Gastal. What helps this pharmacological agent?

What helps Gastal?

Gastal refers to pharmacological group medicines antacid type. The composition of this pharmaceutical preparation includes substances that have a beneficial effect on the gastric mucosa, in particular:

• magnesium aluminum carbonate gel;
• magnesium hydroxide;
• additional substances.

When Gastal tablets enter the body due to active substances, hydrochloric acid in the stomach binds, thereby eliminating discomfort and normalizing natural digestive processes. As practice shows, most often Gastal is taken by people who experience pain in the stomach area after taking fatty or spicy food, as well as for heartburn and after excessive drinking to eliminate toxins.

By binding free hydrochloric acid in the gastric cavity, Gastal helps to normalize the alkaline-acid balance, which allows you to get rid of painful and uncomfortable sensations. Often such a drug is taken by people who adhere to a dietary diet. If you are on a diet to get rid of excess weight, but by chance you had a breakdown and ate 1-2 cakes, then there is nothing to worry about - you can take a Gastala tablet, which will allow you to digest the incoming food faster.

Indications for use Gastal

As already mentioned, Gastal has a very good effect on the stomach, binding free hydrochloric acid. The pharmacological agent begins to act almost immediately after it enters the digestive tract. The effect of the antacid type lasts an average of 2 hours. Due to its active substances, Gastal inhibits the production of a number of enzymes, in particular, lysolecithin and pepsin, and also minimizes the effect of bile acid on the mucous membrane of the esophagus and stomach. According to the instructions, Gastal is recommended to be taken in such cases:

• with gastritis of the hyperacid type;
• in case of detection ulcer pathologies stomach or duodenum;
• with diaphragmatic hernia;
• in case of belching or heartburn;
• with acute pancreatitis;
• in case of development of cholecystitis;
• with the development of erosive processes in the esophagus;
• with vagrant dyspepsia;
• in case of food or other poisoning;
• with a disease of gastroesophageal reflux pathology;
• in the case of the syndrome of delayed excretion of the contents of the stomach.

As already mentioned, Gastal helps well with heartburn, as well as with alcohol intoxication. If in the morning a person experiences hangover syndrome, then with this pharmacological preparation you can get rid of toxins faster.

How to take Gastal?

Gastal can be purchased at any pharmacy. This pharmaceutical preparation is available in the form of tablets. The dosage form of Gastal is the same, the difference is flavor additive and the number of tablets in the package. On pharmacy shelves you can find packages with the number of tablets 12, 24, 30 and 48 pieces. The most common Gastal tablets do not have palatability and covered with the usual shell. But manufacturers also offer cherry and mint flavored tablets. Most often, these pharmacological agents are purchased for children.

Before purchasing and taking Gastal, consult with your healthcare professional, as this drug has a number of contraindications, and its excessive or improper use can lead to side effects. Pay attention to the expiration date and release date. Gastal should be stored in a cool, protected from children and direct contact. sun rays place. You should also observe the established temperature threshold for storing the drug. The course of treatment cannot exceed 14 days, since Gastal is taken exclusively for therapeutic purposes.

It is recommended to take the medicine one hour after a meal or one hour before a night's sleep. In any case, before starting a treatment course, it is best to consult a gastroenterologist. Adults are allowed to take 2 tablets no more than 3 times a day. children age category from 6 to 12 years are allowed to take no more than 1 tablet three times a day. Treating experts do not advise giving this drug to children under the age of six. It is not necessary to drink liquid or swallow a tablet. Her pharmacological form provides absorption. The tablet should be placed on the cheek or under the tongue: active substances within a few minutes, they will begin to be absorbed into the mucous membrane and, together with the saliva produced, will enter the esophagus and stomach.

If gravity and discomfort in the gastrointestinal tract due to overeating or use alcoholic beverages, then you can take one tablet of Gastal. As practice shows, a person experiences relief after a few minutes.

Contraindications to taking Gastal

If you carefully read the instructions for this pharmacological agent Please refer to the list of contraindications. So, Gastal is strictly forbidden to use in such cases:

• with the progression of Alzheimer's disease;
• in case of individual intolerance to individual components, in particular lactose;
• in case of illness kidney failure, with the course of pathology in severe form;
• with the manifestation of an allergic reaction to the constituent components and active substances.

Gastroenterologists advise not to take such a drug to people in old age, as well as women during the period of gestation. In practice, there have been cases when taking Gastal caused diarrhea, constipation, nausea and a change in taste perception.

Side effects

Taking the pharmacological drug Gastal can also provoke the development of side effects. As a rule, they can manifest themselves with the wrong dosage or overuse tablets. Attending specialists and leading pharmacists highlight the following side effects of the drug:

• nausea;
• manifestation allergic reactions in various forms;
• development of osteoporosis;
• diarrhea
• encephalopathy;
• constipation;
• violation of the normal functioning of the kidneys;
• osteomalacia;
• nephrocalcinosis;
• hypercalciuria.

If Gastal is taken by people suffering from renal insufficiency, then as side effects they may experience an increase in the level blood pressure and constant thirst. In this case, you should immediately contact your treating specialist and undergo a full-scale study in order to prescribe a full and balanced treatment course.

With an overdose of Gastal, the above side effects may occur. It is better not to take Gastal with other medicines at the same time. The interval between taking different pharmaceuticals must be at least 2 hours.

Diseases upper division gastrointestinal tract, accompanied by increased acidity of gastric contents - one of the most common in therapeutic practice. Young and middle-aged people are especially susceptible to this pathology. efficient and safe drug that can quickly reduce the acidity in the stomach and eliminate pain, is "Gastal". What features of the product reflect the instructions for the use of "Gastal"?

To date, a whole group of various diseases gastrointestinal tract (GIT), accompanied by increased acidity in the stomach. The most common of them include the following:

• peptic ulcer of the duodenum, stomach;
• gastroesophageal reflux disease;
• erosive lesions of the gastric mucosa, esophagus;
• complications after taking certain medications.

The modern pharmaceutical market offers great amount drugs to eliminate this pathology. They have different mechanisms of action, different forms of release. Every year there are more and more new drugs that can effectively control acid formation in the stomach, while having a minimum of side effects.

What is this drug

The most widely used in medical practice medicines include antacids, medicines that neutralize the acid in the stomach and thus restore the pH to an optimal level. They have been used to treat various diseases of the stomach and esophagus for a long time, almost several centuries.

The modern pharmaceutical market offers an extensive list of various medicines capable of quickly normalizing the pH of gastric contents. At the same time, despite the widespread introduction into practice of such drugs as H 2 -histamine blockers or inhibitors proton pump, antacids have not lost their relevance.

In addition, every year there are more and more new drugs that can effectively control acid formation in the stomach, while having a minimum of side effects. To one of these modern means refers to "Gastal". It reduces the acidity in the stomach within minutes, is relatively safe and can be used for a long time.

How it works

The composition of "Gastal" includes compounds of aluminum and magnesium. They have the ability to bind acid in the stomach and thereby change the acidity to a physiological level. Due to this, heartburn, dyspeptic disorders (nausea, belching, feeling of heaviness in the stomach) are eliminated.

Peculiarities chemical structure the main active ingredients of the drug allow them to have a fairly quick and long-term effect. Within a few minutes after taking the drug, a pronounced therapeutic effect. BUT average duration antacid effect of "Gastala" is about two hours.

In addition, this drug has a number of other positive effects.

• It has a cytoprotective effect. Protects the gastric mucosa, which is associated with the ability of Gastal to stimulate the synthesis of prostaglandins. This effect is especially useful in the presence of gastric ulcers or erosive mucosal defects.
• Stimulates the healing of erosions and ulcers. This is due to the ability of the drug to fix the epithelial growth factor at the site of the pathology.
• Binds bile acids. As well as lysolecithin, which damages the epithelial layer of the stomach.

Also an important advantage of the drug is its exclusively local effect on the pathological focus. After oral administration, it is not absorbed into the systemic circulation, and therefore is practically devoid of side effects.

In the lumen of the stomach, aluminum and magnesium salts interact with hydrochloric acid and form strong bonds. The combination of magnesium and aluminum compounds provides a combined effect of the drug on the walls of the stomach. Magnesium salts in this case cause an initial decrease in acidity, and aluminum salts have a more prolonged effect. Thus, the fastest and longest therapeutic effect is achieved.

The main components of "Gastal" are displayed along with stool through the intestines. In the process of their interaction with the contents of the stomach, magnesium chloride is formed. It can have a laxative effect, especially when taken for a long time.

In what form is it produced

The medicine is available in the form of tablets that can be dissolved in the mouth. The content of aluminum and magnesium salts in them is 0.45 and 0.3 g, respectively.

Tablets "Gastal" have a pleasant taste (cherry or mint) due to the addition of flavors to their composition. Also available are tablets with a neutral taste without the addition of flavors. The medicine contains lactose, mannitol, magnesium and silicon compounds as additional components.

When appointed

The main indications for the use of "Gastal" are any pathological conditions, in which there is an increase in the acidity of gastric juice. These states include:

• heartburn - both arising against the background of organic pathology, and as a result of lifestyle disorders (overeating, bad habits);
• gastritis - inflammation of the stomach lining;
• ulcers and erosion - in the wall of the stomach;
• reflux - reflux of gastric contents into the esophagus (organic, functional);
• pancreatitis - inflammatory process in the pancreas;
• food poisoning- accompanied by an increase in acidity in the stomach;
• bloating - as a result of the predominance of putrefactive or fermentative processes in the intestines.

According to reviews of Gastal tablets, against the background of their use, heartburn disappears, a feeling of heaviness in the stomach, and digestion improves. However, it should be remembered that the use of an antacid does not always eliminate the cause. unpleasant symptoms. It is necessary to consult a doctor, it may be necessary to simultaneously prescribe antacids and other drugs. It should also be borne in mind that "Gastal" is taken only one or two hours after taking other medications.

You can take "Gastal" for the prevention of heartburn, for example, overeating or diet violations. It is especially recommended for people with chronic diseases gastrointestinal tract.

Instructions for use "Gastal"

"Gastal" is used both periodically (that is, to relieve symptoms) and long courses. However, in each specific case gotta stick to following principles Applications:

• drink the drug one hour after eating- as it is celebrated at this time maximum level gastric secretion;
• must be taken before bed- to neutralize acid at night;
• take an extra pill- during periods of maximum pain.

It is better to drink a small amount of medicine, but often. For elimination severe pain you can take "Gastal" 30-40 minutes after eating. In case of a long break between meals, an additional antacid should be taken three hours after the meal.

The tablet is taken whole and kept in the mouth until completely dissolved. The usual dosage of "Gastala" is four to six tablets per day. Maximum daily dosage- eight tablets.

Children under six years of age are not prescribed Gastal lozenges. For the treatment of patients from six to 12 years old, use a dose half that of an adult.

What are the possible side effects

Usually the drug is very well tolerated by patients. Extremely rarely, "Gastal" can provoke the following side effects:

• nausea, rarely vomiting
• discomfort, pain in the stomach;
• diarrhea or, conversely, constipation;
• change in taste in the mouth;
• allergic manifestations.

For the entire period of application this medicine there were no cases of its overdose. However, long-term use of an antacid can cause:

• decrease in blood phosphorus and calcium;
• increase in the blood of magnesium and aluminum;
• violations of the kidneys;
• osteoporosis;
• encephalopathy.

Especially often these phenomena are observed in people with impaired renal function. Against the background of long-term use of the drug in large doses, they may develop symptoms such as a drop in blood pressure numbers, decreased reflexes, and a feeling of thirst. In this case, treatment is indicated in a hospital setting with the appointment of appropriate symptomatic therapy.

Contraindications

Gastal treatment is contraindicated in the following situations:

• individual intolerance to the components of the drug;
• low levels of phosphorus in the blood;
• violation of the filtration function of the kidneys;
• Alzheimer's syndrome.

"Gastal" during pregnancy and lactation is prescribed only on the recommendation of a doctor. It is also a contraindication childhood up to six years old.

Acquisition, analogues

"Gastal" is an over-the-counter drug. Its cost is relatively low. One package containing 12 tablets costs from 150 to 170 rubles (data for December 2017).

With absence this drug in a pharmacy, you can buy its analogues, which also have an antacid effect:

• "Maalox";
• "Renny";
• "Almagel";
• "Gaviscon".

These drugs also have a neutralizing effect on hydrochloric acid and restore the physiological pH level in the stomach. However, they may have a slightly different composition and form of release. In case of changing the drug, it is better to consult your doctor.

"Gastal" is a modern medicine. It has high level safety, does not cause systemic adverse reactions, can be used periodically and for a long time. The use of "Gastal", according to doctors and patients, very quickly eliminates signs of increased acidity of the stomach, and also promotes the regeneration of the gastric mucosa and healing ulcer defects.

"Gastal", what does this effective antacid medicine help with? The drug lowers the acidity of the stomach and relieves digestive disorders. "Gastal" instructions for use recommends taking with a stomach ulcer and gastritis.

Varieties and composition

"Gastal" is produced in tablets of rounded outlines white color that need to be dissipated. The medicine has a cherry and mint flavor or may be tasteless.

The active elements of the drug "Gastal", on which its action depends, are magnesium hydroxide in a volume of 300 mg and a gel consisting of a mixture of magnesium carbonate and aluminum hydroxide, in an amount of 450 mg. Auxiliary components are: sorbitol, talc, fragrance, mannitol and other substances.

Tablets have a rounded shape, smooth surface and white (cream is allowed) color. They are packaged in a blister of 6 pieces. A cardboard pack contains 2, 4, 6, 8 or 10 blisters with the appropriate number of tablets and instructions for using the drug.

Pharmacology

Means "Gastal", which helps with heartburn, lowers the acidity of gastric juice, brings its level to normal condition. The medicine eliminates digestive disorders. Active ingredients inhibit the effects of pepsin, bile acids and enzymes, including lecithin. The drug protects the gastric mucosa from the destructive effects of an aggressive environment, accelerates the healing of ulcers.

The drug improves the reproduction of mucus and sodium bicarbonate, increases the formation of phospholipids. The effect of taking the tablets occurs immediately and lasts for 2 hours. Inside the drug is not absorbed, it is excreted from the body through the rectum.

The drug "Gastal": what helps

The drug is used both separately and as part of complex therapy. Indications for use include the following conditions and pathologies:

• heartburn caused by alcohol abuse, smoking, unhealthy diet;
• stomach ulcer that develops on the background of taking medical devices, high acidity and other aggressive factors;
• erosion of the mucous membrane of the esophagus, small intestine, stomach;
• pancreatitis;
• dyspepsia;
• duodenitis;
• hernia of the esophageal inlet of the diaphragm;
• biliary dyskinesia.

The drug "Gastal": instructions for use

The medicine is used one hour after a meal. The tablets must be sucked until they dissolve. Adult patients and children weighing over 50 kg should use 1-2 tablets up to 5 times a day. The last dose should be before bedtime. The daily volume of the drug should not exceed 8 capsules.

Take the drug "Gastal" instruction for use prescribes for 2 weeks. For heartburn, use 1-2 capsules 4-5 times a day, regardless of meals. For children weighing less than 50 kg and up to 12 years of age, tablets are given in half the dose.

Contraindications

You can not drink "Gastal", from which the state of health may worsen, with:

• Alzheimer's disease;
• disorders of the kidneys in a chronic form;
• hypersensitivity to the composition;
• hypophosphatemia;
• children under 6 years of age.

Caution during therapy must be observed by pregnant women and nursing mothers, as well as in the treatment of children under 12 years of age.

Side effect

The medicine is well tolerated by patients. Negative reactions organisms are observed in rare situations. Side effects include:

• allergy;
• dyspepsia;
• stool changes;
• vomiting or nausea;
• osteoporosis;
• changes in taste perception;
• nephrocalcinosis;
• kidney failure.

Price and analogues

"Gastal" is most often drunk for heartburn. According to this indication, the medicine can be replaced: "Remmax-KV", "", "". You can buy Gastal lozenges, the price of which starts from 130 rubles, without a prescription.

Vacation and storage conditions

In the pharmacy network, the drug is dispensed without a prescription. If you have any doubts or questions about the use of Gastal tablets, you should consult your doctor.

The shelf life of Gastal tablets is 3 years from the date of their release. It is necessary to store the drug in a dark, dry place at an air temperature not higher than + 25 ° C. Keep away from children.

Patient opinions

People who used the drug "Gastal" leave positive reviews. They note the speed of action of the tablets, their pleasant taste and duration of action. Reviews about side effects practically do not occur.

Tradename: Gastal ®

INN or grouping name: -

Dosage form:

Compound:

Description:
Round tablets from white to cream color with a smooth surface and a chamfer.

Pharmacological group: Antacid

ATC Code: A02AX

Pharmacological properties

Pharmacodynamics
The drug Gastal - combined antacid, which reduces hyperacidity gastric juice and does not have a stimulating effect on the secretion of gastric juice.

Aluminum hydroxide-magnesium carbonate gel and magnesium hydroxide provide immediate (immediately after ingestion) and long-term (about 2 hours) neutralization of gastric hydrochloric acid, while maintaining acidity in the stomach at a physiological level (pH 3-5). One tablet of Gastal neutralizes 21.5 mmol of hydrochloric acid.

The drug Gastal ® inhibits the action of pepsin, lysolecithin and bile acids, eliminates dyspeptic symptoms. Enhances protective and regenerative processes in the gastric mucosa. Aluminum ions have a cytoprotective effect by increasing the secretion of mucin and sodium bicarbonate, activating prostaglandin E2 and NO, accumulating epidermal growth factor at the site of mucosal injury, and increasing the concentration of phospholipids in the walls of the stomach.

Pharmacokinetics
The drug Gastal does not have a systemic effect in patients with normal function kidneys. After interaction with hydrochloric acid of gastric juice, aluminum hydroxide reacts with phosphates and carbonates in alkaline environment intestines and is excreted in the feces in the form of insoluble salts. Magnesium hydroxide reacts with hydrochloric acid to gastric juice with the formation of magnesium chloride, which has osmotic properties and a mild laxative effect, which neutralizes the fixing effect of aluminum hydroxide in small intestine. Magnesium ions are excreted in the feces as insoluble carbonate.

Indications for use
Heartburn, dyspeptic symptoms (after taking medications, alcohol, coffee, dietary errors, smoking); conditions accompanied by increased acid formation: peptic ulcer stomach and duodenum, gastritis; reflux esophagitis; hernia esophageal opening diaphragm.

Contraindications
Hypersensitivity to aluminum, magnesium salts or other components of the drug; severe renal failure; Alzheimer's disease; hypophosphatemia; lactose intolerance, lactase deficiency or glucose-galactose malabsorption; children's age up to 6 years.

Carefully
In chronic renal failure (CRF), pregnancy and during breastfeeding, adults and children over 12 years old weighing less than 50 kg, children from 6 to 12 years old, the elderly.

Use during pregnancy and during breastfeeding
The drug Gastal is not excreted from breast milk. When used during pregnancy and during breastfeeding, it is necessary to evaluate the ratio of benefit to the mother and risk to the fetus and infant.

Dosage and administration
Inside, gradually dissolving in the mouth.

Adults and children over 12 years of age weighing at least 50 kg
1-2 tablets 4-6 times a day approximately 1 hour after meals and at bedtime, but not more than 8 tablets per day. The duration of admission is not more than 2 weeks.
Similar doses are recommended for treating heartburn with or without food.
Adults and children over 12 years old weighing less than 50 kg, children aged 6 to 12 years
The dose is half the recommended dose for adults and children over 12 years of age weighing at least 50 kg. The duration of admission is not more than 2 weeks.
Patients with CKD
Dose adjustment is not required. The duration of admission is not more than 2 weeks.

Overdose
Symptoms of acute overdose are not described.
At long-term use high doses of drugs containing aluminum and magnesium may develop hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesemia, hyperaluminemia, encephalopathy, nephrocalcinosis and impaired renal function. Perhaps the development of more pronounced adverse reactions from the gastrointestinal tract (GIT) (constipation, diarrhea), in patients with renal insufficiency - thirst, lowering blood pressure, hyporeflexia. Treatment: symptomatic therapy.

Side effect
When using the drug in recommended doses adverse reactions rare (at least 0.01%, but less than 0.1%): nausea, constipation, diarrhea, change taste sensations. AT exceptional cases allergic reactions are possible.

Interaction with other drugs
The drug Gastal simultaneous application enhances the activity of levodopa and nalidixic acid, reduces and slows down the absorption of quinolones, isoniazid, naproxen, iron preparations, indomethacin, chlorpromazine, beta-blockers, diflunisal, H2-histamine receptor blockers, fat soluble vitamins, indirect anticoagulants, barbiturates.

When interacting with metal ions that are part of antacids, tetracyclines form insoluble chelate complexes; as a result of this interaction, the absorption of tetracyclines is reduced by more than 90%. Simultaneous reception these drugs is not possible. If concomitant use is necessary, tetracycline should be taken at least 2 hours before taking an antacid.

In the presence of aluminum and magnesium hydroxides contained in the antacid, the absorption of ciprofloxacin and ofloxacin is reduced by 50-90%.

In the presence of antacids, the bioavailability of captopril is significantly reduced, and the combined use of antacids and metoprolol leads to a decrease in the concentration of metoprolol in the blood plasma.

The simultaneous use of high doses of antacids can reduce the absorption of ranitidine by 10-33%.

The use of antacids does not affect the bioavailability of amoxicillin, cephalexin and the combination of amoxicillin and clavulanic acid, but can significantly reduce the absorption of doxycycline from the gastrointestinal tract.

An increase in urine pH during antacid therapy may increase the tubular reabsorption of basic (alkaline) drugs and reduce the reabsorption of acidic compounds. Antacids may reduce and delay the absorption of salicylates, including acetylsalicylic acid, and also, by increasing the pH of the urine, contribute to a more rapid excretion of salicylates in the urine from the body, with a concomitant decrease in their concentration in the blood serum by 30-70%. The absorption of cardiac glycosides, including digoxin and digitoxin, does not significantly decrease when used simultaneously with antacids. M-anticholinergics, slowing down the motility of the stomach, increase the duration of the drug Gastal ® .

In order to prevent possible interaction drug Gastal ® with other medicines it is recommended to take it 1 hour before or 1 hour after their use.

special instructions
The recommended doses and duration of treatment should not be exceeded when used in patients with impaired renal function.

Influence on the ability to drive vehicles and work with machinery
The use of the drug Gastal does not affect the ability to drive vehicles and control other mechanisms.

Release form
Lozenges.
6 tablets in a PVC / aluminum foil blister.
On 2, 4, 5, 8 or 10 blisters together with the application instruction in a cardboard pack.

Storage conditions
Store at a temperature not exceeding 25 °C. Keep out of the reach of children.

Shelf life
3 years.
Do not use after the expiry date stated on the packaging.

Terms of dispensing from pharmacies
Over the counter.

RU owner:
Pliva Krakow, A.O. Pharmaceutical Plant, Poland

Manufacturer:

Consumer complaints should be directed to:
OOO "Teva"
119049, Moscow, st. Shabolovka, 10, building. one.

Registration number: P N014448/01
Tradename: Gastal®
INN or grouping name: -
Dosage form: lozenges
Compound
1 tablet contains: active substances: aluminum hydroxide - magnesium carbonate gel 450.0 mg, magnesium hydroxide 300.0 mg; excipients: mannitol (E421) 120.00 mg, sorbitol (E420) 50.00 mg, lactose monohydrate 30.00 mg, corn starch 75.80 mg, sodium cycpamate 7.00 mg, sodium saccharinate 0.20 mg, talc 28.00 mg, magnesium stearate 6.00 mg, peppermint flavor 3.00 mg.
Description:
Round tablets from white to cream color with a smooth surface and a chamfer.
Pharmacological group: antacid
ATC Code: A02AX

Pharmacological properties

Pharmacodynamics
Gastal® is a combined antacid agent that reduces the increased acidity of gastric juice and does not have a stimulating effect on the secretion of gastric juice.
Aluminum hydroxide-magnesium carbonate gel and magnesium hydroxide provide immediate (immediately after ingestion) and long-term (about 2 hours) neutralization of gastric hydrochloric acid, while maintaining acidity in the stomach at a physiological level (pH 3-5). One tablet of Gastal® neutralizes 21.5 mmol of hydrochloric acid.
The drug Gastal® inhibits the action of pepsin, lysolecithin and bile acids, eliminates dyspeptic symptoms. Enhances protective and regenerative processes in the gastric mucosa. Aluminum ions have a cytoprotective effect by increasing the secretion of mucin and sodium bicarbonate, activating prostaglandin E2 and NO, accumulating epidermal growth factor at the site of mucosal injury, and increasing the concentration of phospholipids in the walls of the stomach.
Pharmacokinetics
The drug Gastal® does not have a systemic effect in patients with normal renal function. After interaction with hydrochloric acid of gastric juice, aluminum hydroxide reacts with phosphates and carbonates in the alkaline environment of the intestine and is excreted in the feces in the form of insoluble salts. Magnesium hydroxide reacts with hydrochloric acid in gastric juice to form magnesium chloride, which has osmotic properties and a mild laxative effect that neutralizes the fixative effect of aluminum hydroxide in the small intestine. Magnesium ions are excreted in the feces as insoluble carbonate.

Indications for use

Heartburn, dyspeptic symptoms (after taking medications, alcohol, coffee, dietary errors, smoking); conditions accompanied by increased acid formation: peptic ulcer of the stomach and duodenum, gastritis; reflux esophagitis; hiatal hernia.

Contraindications

Hypersensitivity to aluminum, magnesium salts or other components of the drug; severe renal failure; Alzheimer's disease; hypophosphatemia; lactose intolerance, lactase deficiency or glucose-galactose malabsorption; children's age up to 6 years.

Carefully

In chronic renal failure (CRF), pregnancy and breastfeeding, adults and children over 12 years of age weighing less than 50 kg, children aged 6 to 12 years, old age.

Use during pregnancy and during breastfeeding

The drug Gastal® is not excreted in breast milk. When used during pregnancy and during breastfeeding, it is necessary to evaluate the ratio of benefit to the mother and risk to the fetus and infant.

Dosage and administration

Inside, gradually dissolving in the mouth.

1-2 tablets 4-6 times a day approximately 1 hour after meals and at bedtime, but not more than 8 tablets per day. The duration of admission is not more than 2 weeks.
Similar doses are recommended for treating heartburn with or without food.
Adults and children over 12 years old weighing less than 50 kg, children aged 6 to 12 years
The dose is half the recommended dose for adults and children over 12 years of age weighing at least 50 kg. The duration of admission is not more than 2 weeks.

Dose adjustment is not required. The duration of admission is not more than 2 weeks.

Overdose

Symptoms of acute overdose are not described.
With prolonged use of high doses of drugs containing aluminum and magnesium, hypophosphatemia, hypocalcemia, hypercalciuria, osteomalacia, osteoporosis, hypermagnesemia, hyperaluminemia, encephalopathy, nephrocalcinosis and impaired renal function may develop. Perhaps the development of more pronounced adverse reactions from the gastrointestinal tract (GIT) (constipation, diarrhea), in patients with renal insufficiency - thirst, lowering blood pressure, hyporeflexia.
Treatment: symptomatic therapy.

Side effect

Interaction with other drugs

The drug Gastal®, with simultaneous use, enhances the activity of levodopa and nalidixic acid, reduces and slows down the absorption of quinolones, isoniazid, naproxen, iron preparations, indomethacin, chlorpromazine, beta-blockers, diflunisal, H2-histamine receptor blockers, fat-soluble vitamins, indirect anticoagulants, barbiturates.
When interacting with metal ions that are part of antacids, tetracyclines form insoluble chelate complexes; as a result of this interaction, the absorption of tetracyclines is reduced by more than 90%. Simultaneous reception of these drugs is not possible. If concomitant use is necessary, tetracycline should be taken at least 2 hours before taking an antacid.
In the presence of aluminum and magnesium hydroxides contained in the antacid, the absorption of ciprofloxacin and ofloxacin is reduced by 50-90%.
In the presence of antacids, the bioavailability of captopril is significantly reduced, and the combined use of antacids and metoprolol leads to a decrease in the concentration of metoprolol in the blood plasma.
The simultaneous use of high doses of antacids can reduce the absorption of ranitidine by 10-33%.
The use of antacids does not affect the bioavailability of amoxicillin, cephalexin and the combination of amoxicillin and clavulanic acid, but can significantly reduce the absorption of doxycycline from the gastrointestinal tract.
An increase in urine pH during antacid therapy may increase the tubular reabsorption of basic (alkaline) drugs and reduce the reabsorption of acidic compounds. Antacids can reduce and slow down the absorption of salicylates, including acetylsalicylic acid, and also, by increasing the pH of the urine, contribute to a more rapid excretion of salicylates in the urine from the body, with a concomitant decrease in their concentration in the blood serum by 30-70%.
The absorption of cardiac glycosides, including digoxin and digitoxin, does not significantly decrease when used simultaneously with antacids.
M-anticholinergics, slowing down the motility of the stomach, increase the duration of the drug Gastal®.
In order to prevent possible interaction of the drug Gastal® with other drugs, it is recommended to take it 1 hour before or 1 hour after their use.

special instructions

Influence on the ability to drive vehicles and work with machinery