Analgin dose for adults. "Analgin": instructions for use for children, preparation of a lytic mixture at a temperature

Once the mercury column of the thermometer crosses the mark of 37 degrees, a couple of divisions, due to a viral or colds when you begin to experience chills, aching joints, and a headache. In such a state, it is not easy for an adult, much less for a child. But an adult can take analgin tablet to stop the fever. Can children have analgin?

Surely, both therapists and pediatricians have long begun to warn patients that a drug such as analgin poses a certain danger to any of us, regardless of age. Let's take a closer look at the features of this medicine.

How dangerous is analgin for a child?

Why analgin or metamizole, as it is also called, began to be used as an antipyretic is completely unclear. After all, it is not an anti-inflammatory drug like ibuprofen. It is known as a pain reliever, and it is ineffective. Firstly, it does not relieve spasm, but blocks the part of the brain responsible for pain. Secondly, analgin acts for no longer than 2 hours. But side effects he has enough, up to Quincke's edema. Sometimes one of the side effects can lead to the death of a small patient.

Such consequences can be caused by taking analgin in any form: tablets, suppositories, injections. All this became the basis for banning or restricting the use of metamizole in many prosperous countries back in the 60-70s of the last century. Therefore, all further recommendations will concern a single dose of metamizole as a last resort.

Analgin dosage for children

A long time ago, pediatricians around the world began to give parents recommendations not to lower their child’s temperature, especially with analgin, if it has not reached 38.2-38.5 degrees. This will help save the child’s immunity, because the body fights viruses and pathogenic bacteria, which causes the temperature. It is when it increases that pathogenic microorganisms die.

Contrary to popular belief, even a very high temperature of 39 or 40 degrees from the parents’ point of view does not harm health in any way, except for the risk of dehydration.

Modern standards at which a child needs to be given an antipyretic are a temperature of 39-39.5 degrees. At the same time, you must be firmly convinced that he does not have chronic diseases heart and blood vessels. If the baby is not older than 2 months or has heart problems, then the temperature should be brought down at 38.5 degrees.

Analgin should be used for fever only as a last resort, if there are no other drugs at hand. It is important to adhere to the dosage:

• It is strictly prohibited to give metamizole to children under 3 months of age;
• 0.5-1 year - 100 mg per day;
• from 1 year to 3 years you can use 200 mg of analgin per day;
• 3-7 years - 400 mg per day; over 7 years old - 600 mg per day.

All these standards are described for candles. If you have to give a child analgin in tablets, then a child of 2-3 years old can take up to 100 mg at a time, at 3-5 years old - up to 120 mg, at 6-7 years old - 200 mg. A child over 8 years old can be given up to 300 mg.

Dear parents, do not even think about using analgin for several days in a row. It's about only for one-time use and only in the absence of other means to eliminate fever.

Among all antipyretic medications, only ibuprofen is allowed for children.

Paracetamol comes first even among these two drugs. It is sold in various forms and dosages for children. It does not affect the functioning of organs gastrointestinal tract, does not provoke asthma.

A decrease in body temperature in a child occurs when taking paracetamol in an amount of 10-15 mg per 1 kg of weight. It does not have a toxic effect, since active substance enters the body in low concentrations.

Can children have analgin? What do pediatricians say?

The pediatricians' answer is categorical and unambiguous: children should not be given analgin. Him and adults in last years not prescribed and not recommended for use. Therefore, you should always keep antipyretics for children and adults in your medicine cabinet. Do not forget that high temperature indicates the presence of immunity and the body’s fight against pathogenic microorganisms. Let the temperature stay at 39, but antibodies will be produced that prevent the action of bacteria.

Is it possible to give analgin to children - the opinion of Doctor Komarovsky

Analgin may be part of various combination drugs. Therefore, parents need to carefully read the labels on medications.

Dr. Komarovsky claims that in most European countries It is prohibited to use these drugs to treat children. In Israel and Greece, the use of analgin is permitted only under the supervision of a doctor in a hospital. This is due to the fact that analgin has a very negative impact on the hematopoietic system and can even damage the bone marrow.

In the countries of the former CIS, the use of analgin is still practiced. If your pediatrician prescribes analgin to your child, discuss with him the possibility of a replacement this drug to another, alternative.

Answering the question whether it is possible to give analgin to children, Dr. Komarovsky says a firm “no”!

More recently, analgin (metamizole sodium) could be seen in every home medicine cabinet. It was indispensable for headaches, toothaches, high fever, muscle spasms. Moreover, adults, using analgin, without a doubt gave it to children. But due to the latest medical research The question arose about the advisability of using this medicine.

Scientists have proven that regular use This drug can cause changes in blood composition. Therefore, the debate among doctors about the possibility of prescribing analgin to children still remains unresolved. But given the effectiveness of metamizole sodium, it continues to be used not only in pure form, but also as part of a lytic mixture.

What is special about this medicine?

Description of the drug

Analgin is characterized as an antipyretic and analgesic drug. It is quickly absorbed, so the effect of taking it occurs within 20-30 minutes. But the relief does not last long - about two hours.

Analgin is effective for fever and pain of various etiologies. But it should be remembered that metamizole sodium is just a painkiller that does not relieve inflammation and does not have a healing effect.

Doctors warn that it should be used only symptomatically, until it is clarified the real reason pain or fever. The pediatrician must decide whether analgin can be prescribed to children and prescribe it with extreme caution, since in addition to the side pathogenic effects, the drug has a number of contraindications:

• Individual intolerance;
• Kidney diseases and disruption of their functioning;
• Malfunctions of the circulatory system;
• Age - children under 3 months are prohibited from taking analgin.

In addition, with long-term regular use, analgin can lead to disruption of the heart muscle, pathologies in the formation and development of leukocytes and erythrocytes in the blood, platelets, as well as the appearance of allergic reactions.

But, nevertheless, there are circumstances when the use of analgin is justified or is the only way reduce the child's fever. In such cases, it is necessary to strictly follow the pediatrician’s instructions and calculate the dosage of the drug according to age.

Analgin for children: dosage

The drug is available in tablets, injections and in the form of medicinal suppositories (rectal suppositories). The amount of active substance is indicated on each form. As a rule, in tablets for children, the concentration of metamizole sodium is reduced.

Analgin for children in suppositories is the most convenient form for younger age. They are available in dosages of 100, 200 and 250 mg. If it is necessary to use rectal suppositories for a baby aged 3 to 12 months, the minimum dosage is divided in half. Children from one to three years old are given a whole suppository (100 mg). Children from three to seven years old are prescribed 1-2 suppositories of 200 mg. At the age of eight to fourteen years, suppositories of 250 mg are recommended for use in the amount of 1-2 suppositories per dose. The drug can be used up to two times a day.

The dosage of injections for children varies according to age, and injections are prescribed only in case of individual tolerance. Most often, analgin is administered to children for fever in combination with papaverine and diphenhydramine. Such lytic mixture has a powerful antipyretic effect and is used by emergency doctors.

If parents independently decide to give their child pills, then it is necessary to strictly observe the one-time dosage of analgin for children:

• 2-3 years – 50-100 mg;
• 4-5 years – 100-200 mg;
• 6-7 years – 200 mg;
• 8-14 years – 250-300 mg.

Take tablets 2-3 times a day.

Analgin is one of the best means in the fight against pain of various origins: radiculitis, headache, flu, neuralgia, rheumatism, febrile conditions, myositis.

Analgin has very pronounced anti-inflammatory, analgesic and antipyretic properties. When the drug enters the body, it quickly dissolves and is absorbed into the blood, which explains its rapid effect.

You can find Analgin on sale in the form of injection ampoules, rectal suppositories and tablets. In each individual case, the most suitable way administration of the drug. Analgin for children is produced in the form of tablets or suppositories.

Indications for use

Before you start taking this or that medicine, you must study the instructions in detail and act in accordance with the information specified in it. According to the instructions, Analgin can be used in the following cases:

• Rheumatism;
• Feverish conditions;
• Flu;
• Pain localized in the pelvic area;
• Radiculitis;
• Parainfluenza;
• Myositis;
• Headache;
• Neuralgia;
• Muscle pain;
• Chorea.

You should not self-medicate; if the pain does not go away after the first dose of the drug, then you should consult a doctor to solve the problem.

Analgin: instructions for use

According to the recommendations of the manufacturer of this drug, Analgin should be taken 2-3 times a day in an amount of 250-500 mg. You can drink a maximum of 1 g of painkiller at one time, and daily amount should not exceed 3 g.

The drug can be administered in three main ways - rectally, orally and by injection.

At severe pain, feverish conditions and in other cases when it is required in short term improve the patient's condition, intramuscular and intravenous use Analgina. The drug should be administered 2-3 times during the day. As a rule, a single dose of the drug varies from 250 to 500 mg. In extreme cases, the dosage can be adjusted to a maximum of 1 g per dose. No more than 2 g of the drug can be administered within 24 hours.

When using the drug rectally, an adult can use suppositories in dosages of 300, 1000 and 650 mg.

In severe cases, Analgin with diphenhydramine can be used as prescribed by a doctor. The dosage is determined in each case individually depending on the nature of the disease and the patient’s condition.

Analgin for children: instructions for use

Analgin is widely used in the treatment of children. This is one of the most effective means to reduce high temperature. It has an effect within a few minutes and relieves headaches and muscle pain.

For children under 12 months of age, the drug can only be administered by injection. During intramuscular injections it is necessary to ensure that the temperature of Analgin (solution) is approximately the same as the patient’s body temperature. If you need to administer a large dose of the drug, more than 1 g, then use intravenous route. It is very important in this case to be prepared for anti-shock therapy.

Analgin can be given to children in the form of tablets starting from the age of two. For the sick different ages different ones are registered therapeutic doses facilities:

• No more than 200 mg is recommended for children aged 6-7 years;
• A dose of 100 to 200 mg should be taken by children 4-5 years old;
• 50 to 100 mg of the medicine should be given to children aged 2-3 years;
• 250-300 mg is the dose for children over 8 years old.

Only the attending physician can prescribe medications.

According to the instructions, Analgin can be used to treat children in the form of rectal suppositories. The dosage is determined depending on the nature of the disease and the age of the child. The manufacturer recommends the following regimens for using the drug:

• 200 mg of medication is recommended for children aged 1 to 3 years;
• For children 8-14 years old, 200-600 mg should be taken;
• For children aged 6-12 months, the dosage should not exceed 100 mg;
• Children 1-3 years old are prescribed suppositories with a dosage of 200 mg.

When administering the drug rectally, the child must lie down for a while to active substance dissolved and worked.

Side effects, contraindications

Given medicine can cause a number of side effects, if they occur, the use of Analgin should be stopped or the dosage reduced:

• Agranulocytosis;
• Headache;
• Skin rash;
• Leukopenia;
• Dizziness;
• Fever.

Contraindications to the use of the drug:

• Rheumatic attack;
• Inhibition of hematopoiesis;
• Last 6 weeks and first trimester of pregnancy, lactation;
• Blood diseases;
• Individual intolerance;
• Hemolytic hereditary anemia;
• Anemia;
• Dysmenorrhea;
• Aspirin asthma;
• Leukopenia;
• Liver, kidney failure.

For children under 3 months, Analgin is prescribed with caution and under the supervision of a doctor. The same applies to people with kidney disease and ethanol abuse. In case of unstable blood circulation and systolic blood pressure, intravenous medication should be taken strictly under the supervision of a physician.

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Analgin, tablets (Belmedpreparaty): instructions for use

Compound

Each tablet contains:

active substance: metamizole sodium (analgin) – 500 mg;

Description

pharmachologic effect

Analgin has analgesic, antipyretic and moderate anti-inflammatory effects. Inhibits the activity of cyclooxygenase, reduces the formation of endoperoxides, bradykinins, some prostaglandins, free radicals, and inhibits lipid peroxidation. It prevents the conduction of painful extra- and proprioceptive impulses along the Gaulle and Burdach bundles, increases the threshold of excitability of the thalamic centers of pain sensitivity, and increases heat transfer.

Pharmacokinetics

Indications for use

Acute pain after injury or surgery;

Pain caused by a neoplasm;

Other acute or chronic intense pain when others therapeutic measures impossible;

High temperature that does not respond to other measures.

Parenteral administration is indicated only if enteral administration is not possible.

Contraindications

Analgin should not be used:

At hypersensitivity to metamizole and other pyrazolone derivatives or pyrizalidins (including patients who have developed agranulocytosis after using these substances) or any other ingredients of analgin;

In patients with a history of aspirin asthma or analgesic intolerance syndrome (urticaria, angioedema), in patients with bronchospasm or other forms of anaphylactoid reactions to salicylates, paracetamol or other non-narcotic analgesics such as diclofenac, ibuprofen, indomethacin or naproxen;

In case of dysfunction bone marrow(for example, after treatment with cytostatics) or diseases of the hematopoietic system;

Hereditary hemolytic anemia associated with deficiency of glucose-6-phosphate dehydrogenase;

Patients with systolic blood pressure below 100 mm Hg. st;

In case of acute intermittent porphyria (risk of an attack of porphyria);

In the last trimester of pregnancy.

500 mg tablets are contraindicated for use in children under 10 years of age.

Pregnancy and lactation

There is insufficient data on the use of analgin during pregnancy in humans. In animal studies, metamizole did not reveal a teratogenic effect. Because there is insufficient data in humans, analgin should not be taken in the first trimester of pregnancy and should only be used in the second trimester after careful assessment medical benefit and risk.

Despite the fact that analgin is a weak inhibitor of prostaglandin synthesis, the possibility of premature closure of the ductus arteriosus and perinatal complications cannot be ruled out. Therefore, analgin is contraindicated during the last trimester of pregnancy.

Analgin metabolites are released in breast milk, which is why its use during lactation is not recommended. IN exceptional cases Breastfeeding is possible 48 hours after taking analgin.

Directions for use and doses

The dosage depends on the intensity of pain, fever and individual sensitivity in response to taking analgin.

The lowest effective dose that controls pain and fever should be selected.

In children, to reduce fever, a sufficient dose of metamizole is 10 mg per kilogram of body weight.

The onset of action ranges from 30 to 60 minutes after oral administration and 30 minutes after parenteral administration.

For children over 10 years of age and adolescents under 14 years of age, a single dose of metamizole is 8-16 mg/kg. Adults and adolescents over 15 years of age (>53 kg) can take up to 1000 mg per dose. In case of insufficient effect of a single dose, depending on the maximum daily dose, the maximum single dose can be taken up to 4 times a day. The table below contains the recommended dosage and maximum doses:

Elderly patients. In elderly patients, the dose should be reduced, since the elimination of metabolites may be slowed down when taking analgin.

With decreased renal function and impaired creatinine clearance. In this category of patients, the dose should be reduced, since the excretion of metabolic products may be slowed down when taking metamizole.

Impaired renal or hepatic function. High doses should be avoided if renal or hepatic function is reduced. Short-term use without dose reduction is possible. Long-term use unacceptable.

Mode of application. The method of administration depends on what you want therapeutic effect and the patient's condition. In many cases, oral administration is sufficient to achieve a satisfactory effect. For a rapid onset of effect, when oral or rectal administration is not possible, intravenous or intramuscular injection. When choosing a method of administration, it is important to remember that parenteral administration of drugs is associated with increased risk anaphylactic or anaphylactoid reactions.

500 mg tablets should be swallowed whole, with sufficient quantity liquids (for example, a glass of water).

Side effect

Frequency of possible side effects: very common (≥ 1/10); often (≥1/100 to<1/10); нечасто (≥ 1/1000 до <1/100); редко (≥ 1/10 000 к <1/1000), очень редко (<1/10 000) и неизвестно (не может быть оценена на основе имеющихся данных).

Allergic reactions. Infrequently : rash; rarely: maculopapular exanthema, anaphylactic or anaphylactoid reactions. Occurs mainly within the first hour after administration. Manifest in the form of skin reactions (such as: itching, burning, redness, rash, swelling), rarely shortness of breath. May occur with more severe forms, such as: urticaria, severe Quincke's edema (including the larynx), severe bronchospasm, heart rhythm disturbances, arterial hypotension (sometimes preceded by an increase in blood pressure (BP)).

If skin reactions occur, taking Analgin should be stopped immediately.

Very rare: analgesic-induced bronchial asthma (including in patients with aspirin-induced asthma), Stevens-Johnson syndrome or Lyell's syndrome, shock.

Blood and lymphatic system. Rarely: leukopenia. Very rare: agranulocytosis or thrombocytopenia. They may occur even if Analgin was previously used without complications. The risk of developing agranulocytosis may be increased if Analgin is taken for more than 1 week.

Agranulocytosis is characterized by high fever, chills, sore throat, difficulty swallowing, inflammation of the mouth, nose, throat and genitals, or anal itching. The erythrocyte sedimentation rate (ESR) is significantly accelerated, the number of granulocytes is significantly reduced or the latter are completely absent. In this case, taking Analgin should be stopped immediately.

The cardiovascular system. Uncommon: hypotensive reactions during or after use of the drug.

Diseases of the kidneys and urinary tract. Very rare: acute deterioration of renal function, after which proteinuria, oligo- or anuria, acute renal failure, acute interstitial nephritis may develop. Discoloration of urine red.

Overdose

Symptoms: hypothermia, marked decrease in blood pressure, palpitations, shortness of breath, tinnitus, nausea, vomiting, gastralgia, weakness, oliguria, anuria, drowsiness, delirium, impaired consciousness, tachycardia, convulsive syndrome; the development of acute agranulocytosis, hemorrhagic syndrome, acute renal and liver failure, paralysis of the respiratory muscles is possible.

Interaction with other drugs

Chlorpromazine or other phenothiazine derivatives - simultaneous use may lead to the development of severe hypothermia;

Radiocontrast agents, colloidal blood substitutes and penicillin should not be used during treatment with analgin;

Cyclosporine - with simultaneous use, the concentration of cyclosporine in the blood decreases;

Oral hypoglycemic drugs, indirect anticoagulants, corticosteroids and indomethacin - analgin increases the activity of these drugs by displacing them from protein binding;

Phenylbutazone, barbiturates and other hepatoinducers when used simultaneously, they reduce the effectiveness of analgin;

Non-narcotic analgesics, tricyclic antidepressants, hormonal contraceptives and allopurinol - simultaneous use of Analgin with these drugs can lead to increased toxicity;

Sedatives and tranquilizers (sibazon, trioxazine, valocordin) enhance the analgesic effect of Analgin;

Thiamazole and Sarcolysin increase the risk of developing leukopenia;

Codeine, histamine H2 blockers and propranolol enhance the effect of analgin.

Caution is required when used simultaneously with sulfonamide hypoglycemic drugs (the hypoglycemic effect is enhanced) and diuretics (furosemide).

Myelotoxic drugs lead to increased hematotoxicity.

Features of application

Precautionary measures

Painkillers containing the pyrazolone derivative metamizole carry a rare but life-threatening risk of shock and agranulocytosis.

Patients with atopic bronchial asthma and hay fever have an increased risk of developing hypersensitivity reactions.

Patients with anaphylactoid reactions or other immunologically mediated reactions (eg, agranulocytosis) may react in the same way to other pyrazolones and pyrazolidines.

When using the drug, agranulocytosis may develop. Therefore, if an unmotivated increase in temperature, chills, sore throat, difficulty swallowing, stomatitis, as well as inflammation of the external genitalia and anus is detected, immediate discontinuation of the drug is necessary.

When choosing a method of administration, it is important to remember that parenteral administration of analgin is associated with an increased risk of anaphylactic or anaphylactoid reactions.

The risk of potentially severe anaphylactoid reactions to analgin increases significantly in patients with:

Asthma syndrome on analgesics or angioedema on non-narcotic analgesics;

Bronchial asthma, especially with concomitant rhinosinusitis and nasal polyps;

Chronic urticaria;

Intolerance to dyes (for example, tartrazine) and preservatives (for example, benzoates);

Alcohol intolerance. These patients may react to alcoholic beverages even in small quantities with symptoms such as sneezing, watery eyes, and severe facial flushing. Such alcohol intolerance may be a symptom of previously diagnosed asthma in response to analgesics.

When prescribed to patients with acute cardiovascular pathology, careful monitoring of hemodynamics is necessary. Use with caution in patients with blood pressure levels below 100 mm Hg. Art., with myocardial infarction, multiple trauma, with anamnestic indications of liver and kidney diseases (pyelonephritis, glomerulonephritis), during treatment with cytostatics, with chronic alcoholism, a burdened allergic history, blood diseases.

Analgin can lead to hypotensive reactions. These reactions may be dose dependent. These reactions usually occur with parenteral rather than enteral administration. The risk of developing such reactions increases:

With rapid intravenous administration;

In patients with previous hypotension, dehydration or dehydration, unstable blood pressure, or incipient circulatory failure (for example, in patients with multiple traumas or a heart attack);

In patients with high fever.

These patients require careful evaluation and close monitoring. Preventive measures (such as circulatory stabilization) may be necessary to reduce the risk of hypotensive reactions.

In exceptional cases, analgin can be used in patients in whom a decrease in blood pressure is unacceptable, for example, with severe coronary heart disease or corresponding stenosis of the cerebral arteries. Use is possible only after careful monitoring of hemodynamic parameters.

Patients with renal or hepatic insufficiency should take analgin only after a careful assessment of the benefits, risks and necessary precautions.

It is necessary to consult with the patient before administering analgin. In patients with an increased risk of anaphylactic reactions, analgin can be used only after a thorough analysis of the possible risks in relation to the expected benefits. When taking analgin in such cases, the patient should be carefully monitored to ensure medical care and emergency preparedness.

Release form

10 tablets in a blister pack or in a blister-free pack. One or two contour packages along with instructions for use are placed in a cardboard pack.

Packaging for hospitals: 120 contour cell-free packages or 150 contour cell packaging with instructions for use are placed in a cardboard box.

Storage conditions

In a place protected from moisture and light at a temperature not exceeding 25°C.

Keep out of the reach of children.

Best before date

Conditions for dispensing from pharmacies

Analgin, tablets (Belmedpreparaty) analogues, synonyms and group drugs

Self-medication can be harmful to your health.
You should consult your doctor and read the instructions before use.

Metamizole sodium

Composition and release form of the drug

◊ Pills white or white with a slightly yellowish tint, round, flat-cylindrical, scored and chamfered.

Excipients: potato starch, sucrose (powdered sugar), calcium stearate, talc.

10 pieces. - contour cellular packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.
20 pcs. - cans (1) - cardboard packs.
30 pcs. - cans (1) - cardboard packs.

pharmachologic effect

Analgesic-antipyretic. It is a derivative of pyrazolone. It has an analgesic, antipyretic and anti-inflammatory effect, the mechanism of which is associated with inhibition of prostaglandin synthesis.

Pharmacokinetics

After oral administration, metamizole sodium is rapidly hydrolyzed in gastric juice to form the active metabolite 4-methyl-amino-antipyrine, which, after absorption, is metabolized into 4-formyl-amino-antipyrine and other metabolites. After intravenous administration, metamizole sodium quickly becomes inaccessible for determination.

Metamizole sodium metabolites are not protein bound. The largest portion of the dose is excreted in the urine in the form of metabolites. Metabolites are excreted in breast milk.

Indications

Pain syndrome of various origins (renal and biliary colic, neuralgia, myalgia; with injuries, burns, after operations; toothache, menalgia). Fever in infectious and inflammatory diseases.

Contraindications

Severe renal and/or liver dysfunction, glucose-6-phosphate dehydrogenase deficiency, blood diseases, hypersensitivity to pyrazolone derivatives.

Dosage

Adults are prescribed 250-500 mg 2-3 times a day orally or rectally. Maximum single dose- 1 g, daily allowance- 3 g. Single doses for children aged 2-3 years are 50-100 mg; 4-5 years - 100-200 mg; 6-7 years - 200 mg; 8-14 years - 250-300 mg; frequency of administration - 2-3 times/day.

IM or IV slowly for adults - 250-500 mg 2-3 times a day. Maximum single dose- 1 g, daily allowance- 2 g. In children, it is used parenterally at a dose of 50-100 mg per 10 kg of body weight.

Side effects

Allergic reactions:, Quincke's edema; rarely - anaphylactic shock.

From the hematopoietic system: rarely, with long-term use - leukopenia, agranulocytosis.

Local reactions: with intramuscular injection - infiltrates at the injection site.

Drug interactions

When used simultaneously with analgesics-antipyretics and NSAIDs, mutual enhancement of toxic effects is possible.

When used simultaneously with inducers of microsomal liver enzymes, the effectiveness of metamizole sodium may decrease.

With simultaneous use, the activity of indirect, oral hypoglycemic drugs, corticosteroids, indomethacin increases due to their displacement from connection with blood proteins under the influence of metamizole sodium.

When used simultaneously with phenothiazine derivatives, severe hyperthermia is possible; with sedatives, anxiolytics - the analgesic effect of metamizole sodium is enhanced; with tricyclic antidepressants, oral contraceptives, the metabolism of metamizole sodium is disrupted and its toxicity increases; with caffeine - the effect of metamizole sodium is enhanced; with cyclosporine - the concentration of cyclosporine in the blood plasma decreases.

When metamizole sodium is used in combination with pitofenone hydrochloride (has a direct myotropic effect on the smooth muscles of internal organs and causes its relaxation) and with fenpiverinium bromide (m-anticholinergic), their pharmacological action is mutually enhanced, which is accompanied by a decrease in pain, relaxation of smooth muscles and reduction of elevated body temperature.