Can tranexam harm the fetus. Indications for the appointment of expectant mothers

A drug for the treatment of bleeding various etiologies. The drug is sold in pharmacies in the form of tablets. In a hospital setting, it is possible intravenous administration in the form of a solution for infusion.

The most common indication for the use of the drug during pregnancy is uterine bleeding. Less commonly, the drug is prescribed to treat other forms of bleeding disorders. Sometimes Tranexam is used for allergic and inflammatory pathologies any organs.

The composition of the drug

The most important effect of tranexamic acid is antifibrinolytic. The drug helps to turn off the enzyme that causes the breakdown of blood clots. Due to the described action, the drug increases the viscosity of the intravascular fluid, promotes the activation of the coagulation system.

Tranexamic acid also has an anti-inflammatory effect. It reduces the severity of edema, reduces pain syndrome, relieves redness of the skin and mucous membranes.

The drug has an antiallergic effect. The drug reduces the production of substances that cause an atypical reaction of the human body. Tranexamic acid reduces local and systemic manifestations of allergies.

The drug has a high bioavailability, it is well absorbed in the organs gastrointestinal tract. Then the drug enters the blood. The maximum concentration of tranexamic acid in plasma is observed 3 hours after ingestion.

The activity of the drug persists for 18 hours. Complete cleansing blood from traces of Tranexamic acid is observed 4-5 days after the last dose. Most of The drug is excreted from the body through the kidneys along with urine.

Release form and expiration date

In the hospital, Tranexam is used in the form of a solution for intravenous infusion. One milliliter of the drug contains 50 milligrams of the active substance. Solution for infusion has a transparent color, its shelf life is 24 months.

The drug should be stored in a dark, cool place, avoiding contact with sun rays. After the expiration date, the use of the drug is strictly prohibited.

Indications for use

If placental abruption occurred on the periphery, the expectant mother observes uterine bleeding. It has various forms- from brown daub on underwear to scarlet profuse discharge. Quite often, placental abruption is accompanied by cramping pains in the lower abdomen. If symptoms are detected, a pregnant woman should seek immediate medical attention. medical care.

Sometimes placental abruption occurs in the middle part, so the blood cannot go into the uterine cavity. This type of pathology is accompanied by the formation of a hematoma. In the described case, the expectant mother does not observe uterine bleeding; one can only guess about the presence of a problem by the presence of cramping pains.

During pregnancy, Tranexam is taken for bleeding from various organs:

• nasal;
• pulmonary;
• gastrointestinal;
• from the bottom urinary tract.

In rare cases, Tranexam is used to treat inflammatory diseases of the upper respiratory tract- laryngitis, pharyngitis, stomatitis. Also, the drug is prescribed as a component of antiallergic therapy for dermatitis, eczema, urticaria, rash.

The drug is used in postpartum period. It is used to stop excessive bleeding after the baby is born.

The effect of the drug on the fetus

In the course of studies on laboratory animals, it was found that the drug does not have a teratogenic effect on the fetus - Tranexam does not contribute to the occurrence congenital anomalies. Also, the drug does not have a toxic effect - it does not cause growth retardation and development of the unborn child.

Some gynecologists exclude the possibility of using any drugs on early dates pregnancy. Until the 13th week of the gestation period, all organs of the unborn child are laid. Reception medications may contribute to the violation of the division of fetal tissues. However, if there are serious indications, taking Tranexam is not prohibited even in the 1st trimester of pregnancy.

Starting from the second trimester of the gestation period, Tranexam has more wide list indications for admission. By this period, the main organs and systems of the fetus have been formed.

The medicinal product is allowed to be used on later dates pregnancy up to birth period. The drug does not affect uterine activity, so it does not reduce the intensity of contractions. Also, Tranexam does not slow down the opening of the cervix during childbirth.

Instructions for use

The exact dosage, frequency of administration and duration of the course of treatment is determined by the doctor. Usually pregnant women are prescribed 1-3 tablets three times a day through equal intervals time. Average duration therapy is from 5 to 10 days.

Tablets are allowed to be used regardless of the meal. However, to reduce negative side effects, it is recommended to take the drug immediately after eating. The medicine should be taken with a glass clean water without gas.

Tranexam in the form of a solution for infusion is used only in a hospital setting. Jet intravenous administration of the drug is allowed at a dose of 15 milligrams of the active substance per 1 kilogram of the patient's weight. The medicine should be administered every 6-8 hours.

The drug can also be administered with intravenous drip. For this, the drug is diluted in a solution of sodium chloride or glucose. The drug is administered 3 times a day at regular intervals. The average duration of the course of treatment is from 3 to 7 days. Then it is possible to switch to a tablet form of release.

Contraindications

The drug is contraindicated in the presence of thrombophilia of various etiologies. Such diseases include acute infarction myocardium, disorder cerebral circulation, violation of the function of the organ of vision. The drug should not be used in persons with subarachnoid hemorrhage.

Tranexam is prohibited for use in persons with bleeding from upper divisions urinary tract. Also, the drug is not recommended for use in patients suffering from chronic diseases liver in the stage of decompensation.

Side effects

Against the background of drug treatment, the development of allergic reactions is possible. Most often they appear locally - there is a rash like urticaria or dermatitis. Less often, an allergy to the components of the drug is systemic in nature - angioedema or anaphylactic shock.

In very rare cases, Tranexam contributes to disruption of the central nervous system. Patients complain of dizziness, weakness, fatigue. Possibly impaired vision or hearing.

The drug can contribute to the development of pain in the chest area. Also, taking the drug leads to a decrease in numbers blood pressure. AT exceptional cases against the background of the use of tranexamic acid, patients developed thrombosis or thromboembolism.

Traneksam's analogs

Dicynon is a drug produced in the form of tablets and solution for infusion. The drug is used to stop bleeding of various etiologies. In obstetric practice, the medication is prescribed in case of a threat. The drug can be used from the 1st trimester of pregnancy.

Duphaston is a drug that contains a synthetic analogue female hormone progesterone. The drug is used to maintain gestation in the event of a threatened premature termination of pregnancy. The drug is approved for use at any time.

A drug that promotes tissue regeneration. It contains components of the blood of calves. The drug is used as part of complex therapy for uterine bleeding and impaired blood supply to the fetus. The drug can be used from the first trimester of pregnancy.

A medicine containing dipyridamole. The drug is available in the form of tablets. Curantil is indicated to stabilize the condition after thrombosis and embolism. Also, the drug is used in the presence of impaired blood supply to the fetus and its lag in growth and development. The medication is allowed to be used from the early stages of gestation.

Etamzilat is a medicine with the same active ingredient, produced in the form of tablets and injections. The drug is used to treat bleeding of various etiologies, disorders of blood properties, inflammatory diseases. The drug is approved for use from the first weeks of pregnancy.

Currently, one of the most common diagnoses according to statistics is the threat of abortion. This conclusion is heard daily by hundreds of women who are carrying a child. Often for this reason, doctors prescribe Tranexam during pregnancy.

Drug instructions reviews
charging discomfort pulls
power in listening position

Fortunately, medicine has gone far ahead, and our doctors know how to deal with this danger. Great helper Tranexam tablets act.

Indications for prescribing the drug

Typically, interruption occurs when future mother bleeding occurs. Tranexam during pregnancy allows you to make the blood thicker, and also enhances its clotting. Simply put, this drug stops bleeding, prevents a miscarriage from happening.

The drug is prescribed for bleeding

Tranexam is prescribed for:

• the appearance of pains of a pulling nature in the lower abdomen;
• bloody discharge from the vagina, and the sooner the reception is started, the better;
• previously diagnosed miscarriages or the diagnosis of "habitual miscarriage", then the drug can be prescribed from the very beginning of pregnancy as a means of prevention;
• inflammatory processes;
• allergic reactions.

This drug freely crosses the placenta, but does not negative impact to the fruit.

Moreover, during pregnancy, tranexam is prescribed in the early stages, with the exception of cases when a woman has problems with blood clotting, which were observed even before the moment of conception.

Consider the most common causes destination this drug by trimesters.

Instructions for using the medicine

According to the instructions for use, tranexam during pregnancy is a drug that lowers the fibrinolytic activity of the blood. It has a local and systemic hemostatic effect in bleeding caused by an increase in fibrinolysis (platelet pathology), as well as an anti-inflammatory, anti-allergic, anti-infectious, antitumor effect by suppressing the development of kinins and other active peptides involved in allergic and inflammatory processes.

It is mandatory to read the instructions

Consider the dosage of tranexam during pregnancy.

Pills:

• tranexam with hematoma during pregnancy - 1000-1500 mg 2-3 times / day;
• profuse uterine bleeding - 1000-1500 mg 3-4 times / day, duration of administration - 3-4 days;
• bleeding on the background of von Willebrand's disease - 1000-1500 mg 3-4 times / day, duration of therapy - 3-10 days;
• epistaxis - 1000 mg 3 times / day;
• tranexam in the early stages to stop bleeding - 250-500 mg 3-4 times / day until the bleeding stops completely, according to reviews, the duration of the course is about 7 days;
• hereditary angioedema - 1000-1500 mg 2-3 times / day;
• symptoms of allergic reactions, inflammatory processes - 1000-1500 mg 2-3 times / day;
• generalized fibrinolysis - a tranexam dropper is prescribed during pregnancy, followed by a switch to 1000 mg tablets 2-3 times / day.

Injection:

• according to the instructions of tranexam during pregnancy with generalized fibrinolysis, 15 mg / kg is prescribed every 6 hours;
• local fibrinolysis - administration of the drug at a dose of 250-500 mg 2 times / day;
• how to take the drug increased risk the appearance of bleeding - the doctor prescribes individually, as a rule, the dose is 10-11 mg / kg.

As a rule, tranexam is well tolerated during gestation. Sometimes you may experience the following side effects:

• heartburn;
• nausea;
• vomit;
• general weakness;
• dizziness;
• visual impairment;
• heart palpitations;
• development of thrombosis;
• pain in chest;
• allergic reactions: rash, itching, urticaria.

Contraindications.

1. Phlebeurysm.
2. Individual intolerance to the components of the drug.
3. Thrombosis.
4. Subarachnoid bleeding.
5. Kidney disorders.
6. Poor blood supply to the brain, even if it was observed even before conception.
7. You can not administer the drug intravenously if the woman did a blood transfusion or its components.
8. Thrombophlebitis of deep veins.
9. Can't lead simultaneous reception this drug with tetracyclines or diazepon. This can lead to the active formation of blood clots.
10. During breastfeeding, the drug poses a threat to the child, because it is excreted in breast milk.

Need to hear other women's opinions

Pros and cons of this tool

Consider the main advantages and disadvantages of the drug, according to women's reviews.

Women's opinion

Consider a few reviews of women who have experienced the effects of tranexam during pregnancy on themselves.

Margarita Tsvetaeva:

The pregnancy was planned for a long time, but it just didn’t work out for a long time. She went through a course of treatment with a doctor and a year later became pregnant. Happiness knew no bounds. However, I was not happy for long, because already on the 5th week there were strong pulling pains in the lower abdomen, and the next day, bloody discharge appeared. I was very scared and immediately ran to the doctor. They examined me and said that there was a threat of miscarriage. First, the gynecologist prescribed tranexam, said how much to drink. If it does not help, she promised to give a referral to the hospital. I started taking it according to the prescription. Imagine my surprise when on the second day all the symptoms disappeared. I calmed down, but finished the whole course to the end. I am very glad that you can take the drug during pregnancy, especially since the price of this drug is affordable.

Veronika Zagorelskaya:

I am familiar with this drug firsthand, since during my first pregnancy I took it from a sudden bleeding. The effect was immediate, so when the gynecologist told me that in order to prevent a second pregnancy, I need to drink it for another week, I did not resist. I started taking it without hesitation, although there were no clear indications for it. However, this time she began to feel very bad: she felt nauseous, even vomited a couple of times in the morning, she wanted to sleep all the time. I was very worried and went to the gynecologist to check if everything was fine. The doctor examined me and said that common reaction body (side), it's okay and you can continue the course. However, every day I was getting worse, so I did not finish the course to the end. As soon as I stopped taking the pills, my condition improved, but there were already pulling pains in the lower abdomen. A friend advised another drug - diet, they say it is without such side effects. To be honest, I didn’t know what was better to take during pregnancy: dicynone or tranexam, but I didn’t experiment. Went back to the doctor. I was told to finish the course I started, otherwise there may be Negative consequences. Through force, I finished the pills and forgot about all the negative points. But now my opinion about this drug is ambiguous.

Sabina Romanova:

At the 12th week of pregnancy, I was diagnosed with an inflammatory process, which was accompanied by spotting from the vagina. The gynecologist has appointed or nominated many any preparations, including also these tablets. I used to trust my doctor, as she helped me overcome many diseases. That is why I did not even begin to read the instructions for use, but immediately began taking it. Complex therapy helped me get over my illness. I don’t know what role this drug played, but the result is obvious.

"Tranexam" during pregnancy is used most often. Because the drug is aimed at eliminating the risk of miscarriage. Available in 2 forms - tablets and solution for drip or jet injection. During pregnancy, a tablet preparation is most often prescribed, but another option is also possible.

Composition and properties

"Tranexam" refers to a fibrinolysin inhibitor, due to which bleeding is prevented and stopped. Thanks to tranexamic acid, silicon dioxide, microcrystalline cellulose and sodium glycolate, which is part of the drug, the following action is carried out:

1. The drug contributes to the suppression of kinins and some peptides, due to which the allergic reaction and inflammatory processes are eliminated. Therefore, "Tranexam" has anti-inflammatory, antiallergic, antitumor properties.
2. The blood thickens and the process of incoagulability accelerates, which is especially important for bleeding.
3. The uterine tone decreases, due to which there is a risk of miscarriage.
4. If the drug is taken long time, then it has an analgesic effect, that is, an anesthetic.

"Tranexam" is prescribed for pregnant women in such cases:

• bloody issues:
• pulling pain in the lower abdomen;
• premature aging of the placenta;
• exfoliation of the fetal egg;
• propensity to allergies;
• inflammatory processes;
• if you have had miscarriages before;
• miscarriage is suspected.

The drug is prescribed to prevent heavy bleeding after labor activity. And also with heavy or painful menstruation.

The effect of tranexamic acid on the body of a pregnant woman

The main active ingredient of Tranexam is tranexamic acid. It is obtained from the amino acids lysine in a synthetic way.

The peculiarity of the substance is that there is no metabolism, due to which the acid is fully excreted from the body through the kidneys through the urine. Does not penetrate the placenta of the fetus, therefore it is completely safe means.

"Tranexam" is used in medicine not only during pregnancy, but also in other cases. For example, with any bleeding, heavy menstruation.

Quite often, with minor hemorrhages, a hematoma of the uterus is formed. That is, in a certain area this body some amount of blood accumulates, which is subsequently converted into a neoplasm. And this leads to serious consequences. Hematomas are formed in cases where a woman has a violation of blood clotting. "Tranexam" promotes the resorption of these hematomas, as the blood structure is restored.

Possible contraindications and side effects

In some cases, there are adverse reactions :

• nausea and vomiting;
• heartburn and weakness;
• temporary deterioration in visual acuity;
• dizziness and rapid heartbeat;
• pain in the sternum;
• thrombosis;
• allergy - skin rashes accompanied by itching and burning.

Contraindications:

1. It is strictly forbidden to use the drug when varicose veins veins, thrombophlebitis and thrombosis.
2. Intolerance to one of the components of Tranexam.
3. Bleeding of a subarachnoid nature.
4. Pathological disorders of the functionality of the renal system.
5. Circulatory disorders in the brain.
6. breastfeeding, as active substances easily pass into milk.
7. An increased number of red blood cells in the urine, that is, hematuria.
8. Intravenously, the drug is not prescribed in the case when a blood transfusion was performed.
9. It is forbidden to use "Traneksam" together with preparations containing penicillin and tetracycline.
10. Tranexamic acid is incompatible with other hemostatic agents and drugs intended to lower blood pressure.

How and how much you can drink "Tranexam" during pregnancy - dosage

Everyone human body has individual characteristics. So pregnancy is different. But the risk of miscarriage in the first trimester exists in almost every woman. There are many reasons for this. However, the drug "Tranexam" is considered universal, as it is used in all cases.

The most commonly prescribed tablet form. In this case, the tablets are used three times or four times a day, 1 or 2 units, depending on the purpose. You need to drink tablets immediately after eating. The duration of the course of treatment varies from indications. So, a woman can use the drug for 1 week or several. There are no restrictions in the course of admission, since Traneksam is not addictive.

If the doctor prescribes injection solution, then its dosage depends on the purpose of therapy:

1. In case of bleeding from the uterus and hematoma, the drug is administered drip by dropper 2-3 times a day, 1,000-1,500 mg each.
2. If bleeding is detected in the first months of pregnancy, then the dosage is from 250 to 500 mg. The drug is administered four times a day.
3. If an allergic reaction or inflammatory processes is noted, then Traneksam is prescribed twice a day for 1,000-1,500 mg. It is enough to drop 2 times.
4. With generalized fibrinolysis, a dropper is initially placed, and then a tablet form of the drug is prescribed.

The decision to prescribe the dosage of Tranexam is made at the individual level. It depends on the course of the disease and pregnancy, the characteristics of the body, the level of blood loss, etc.

Application at various times

On the first trimester tranexamic acid is prescribed in such cases:

• inflammatory processes;
• tumor neoplasms;
• spotting and bleeding;
• risk of miscarriage;
• allergic to any allergen;
• pharyngitis;
• tonsillitis;
• hemophilia;
• leukemia;
• pathology of the liver;
• angioedema;
• intoxication.

Second trimester:

• pain syndrome in the lower abdomen of a pulling and aching character;
• spotting, blood loss;
• the risk of losing a child.

Third trimester:

• stomach ache;
• the threat of premature birth;
• bleeding and spotting.

What is better to take: "Dicinon" or "Tranexam" during pregnancy?

The drug "Dicinon" refers to the analogue of the drug "Tranexam". However, they have a slight difference. First, it's cost. For example, "Tranexam" (10 tablets) has a price of 230-260 rubles, and "Dicinon" for the same amount - 40-50.

Secondly, the effectiveness of the second is largely different from tranexamic acid, because Tranexam is so strong drug that it is often used as a means of first aid. That is, it can stop the bleeding instantly.

Thirdly, the side reactions of Dicinon are less pronounced. But both types of drugs are produced in both tablet and injectable form. And what to choose specifically for you, the doctor should decide.

Pros and cons of taking

Benefits and taking the drug "Tranexam":

• instant therapeutic effect;
• safety for mother and unborn child;
• relatively low cost of the drug;
• the ability to use for a long time - no addiction;
• in some cases, the duration of the course is only a few days;
• comprehensive effect on the body;
• can be bought at any pharmacy.

Disadvantages:

• it is necessary to strictly adhere to dosages;
• there are a number of contraindications;
• sometimes there are adverse reactions.

Summing up, it should be noted that Traneksam is a fairly effective and safe remedy that will help not only stop bleeding, but also get rid of many other problems. He has many analogues, but only a doctor should be involved in the selection.

There are many reasons that can cause uterine bleeding in women. Often used in treatment modern drug Tranexam - effective remedy, which allows you to cope with the opened bleeding or heavy periods in the shortest possible time.

Description of Tranexam

Often used to treat uterine bleeding medicinal product Traneksam. It is used in therapy to reduce and restore the volume of menstruation, to stop bleeding and reduce the risk of miscarriage against the background of bleeding.

Main active substance this medicine is tranexamic acid. It is able to influence fibrinolysin - a substance contained in the blood and prevents its coagulation.

An increased content of fibrinolysin provokes intense and prolonged bleeding. This happens when platelets are unable to produce enough plasmin, a component that ensures normal blood clotting. Tranexam is able to convert fibrinolysin to plasmin, thereby helping to stop the increased release of bloody biological fluid.

Pharmacological action of the drug on the human body:

• local and systemic hemostatic (hemostatic);
• anti-inflammatory;
• antihistamine (antiallergic);
• anti-infectious;
• antitumor;
• analgesic (pain reliever).

Forms of release and composition of the drug

The drug has two forms of release: tablets and solution for intravenous administration.

Tableted means is a convex, coated with a water-soluble film, white tablets. The solution is a clear liquid, colorless or with a slight light brown tint.

• active substance: tranexamic acid in the amount of 250 or 500 mg;
• auxiliary components:
  • core: cellulose, hyprolose, talc, silicon dioxide, sodium carboxymethyl starch and calcium stearate;
  • shell: titanium dioxide, talc, macrogol, hypromellose.

As part of a solution for injection in an amount of 1 liter:

• tranexamic acid in a volume of 50 g;
• excipient - distilled water up to 1 liter.

Uterine bleeding, in the treatment of which Tranexam helps

Uterine bleeding can be provoked various states or pathologies. They are conditionally divided into 2 categories:

1. The result of systematic violations in different organs or systems.
2. Dysfunctions associated with changes in the functioning of the genital organs.

There are many reasons for such uterine bleeding. Among them:

1. Extragenital (not associated with diseases of the genitourinary system):
   1. Liver diseases such as cirrhosis and liver failure.
   2. Diseases of cardio-vascular system such as atherosclerosis, hypertension.
   3. Infections:
      • flu;
      • measles;
      • sepsis;
      • typhoid fever.
   4. Functional decrease in the work of the thyroid gland.
   5. Blood diseases:
      • hemophilia;
      • hemorrhagic vasculitis;
      • low content of vitamins C and K in the body.
2. Causes associated with pregnancy due to genital diseases:
   1. Pregnancy that occurs with violations in the early stages:
      • uterine;
      • ectopic.
   2. At a later date:
      • scars on the uterus;
      • placental abruption;
      • destruction of cervical tissue;
      • placenta previa.
   3. Generic reasons:
      • rupture of the cervix;
      • delayed separation of the placenta;
      • injury birth canal and genitals;
      • low location of the placenta;
      • afterbirth defects.
   4. Postpartum pathologies:
      • weak uterine tone;
      • delay in the release of the placenta;
      • endometriosis.
3. Genital disorders not related to pregnancy:
   1. Bleeding in different age periods associated with pathologies in the functions of the hypothalamus-pituitary-ovaries-adrenals system (depending on the presence or absence of ovulation, this is the so-called dysfunction):
      • juvenile, related to the period of development of the genital organs and maturation (from 10 to 18 years);
        

        If uterine bleeding manifests itself before the age of 9–10 years, then these may be the consequences of the occurrence of a “false” puberty of the child against the background of the development and growth of ovarian tumors.

      • reproductive (puberty);
      • menopausal, directly dependent on menopause (after 45 years).
   2. Tumors on the internal genital organs, including fibroids.
   3. Ruptures of the ovary or cysts on it.
   4. Uterine trauma.
   5. Inflammatory and infectious diseases reproductive organs:
      • cervical erosion;
      • endometritis;
      • vaginitis and vaginosis;
      • cervicitis;
      • endocervicosis.

Such bleeding may be caused additional row factors:

• chronic ailments;
• emotional and mental overexcitation;
• prolonged stress;
• physical overload;
• heredity;
• hypovitaminosis;
• mental trauma;
• endocrine diseases;
• complications after childbirth or abortion.

In addition to the above indications, the basis for the appointment of Tranexam, at the discretion of the attending physician, may be allergic reactions, blood diseases and surgical interventions.

The risk of developing uterine bleeding is assessed by determining the PCT in a blood test:

Uterine bleeding - video

Contraindications

There are a number of contraindications to the use of Tranexam:

• hypersensitivity to the components of the drug;
• subarachnoid hemorrhage (spontaneous outpouring of blood into the cavity between meninges, the result of a rupture or traumatic brain injury);
• thrombosis of various origins:
  • vessels of the brain;
  • myocardial infarction;
  • thrombophlebitis;
• violation of color perception;
• kidney failure;
• urinary tract hematuria ( high content erythrocytes in urine);
• thrombohemorrhagic complications.

• penicillins;
• tetracyclines;
• agents for the treatment of hypertension;
• other hemostatics (hemostatic drugs).

Tranexam use during pregnancy and lactation

Tranexam is widely used in gynecology as a remedy that can prevent the threat of miscarriage. It is prescribed by a doctor after a thorough examination of a pregnant woman, since if there are some health problems, for example, if thrombosis is detected, the use of this drug is prohibited.

During lactation, the medication is taken exclusively for health reasons, since Tranexam carries a potential risk to the child. At the same time, it is recommended to refuse during treatment breastfeeding and transfer the baby to the mixture.

Possible side effects

When using Tranexam tablets, especially if the prescribed dosage is violated, the following side effects may occur:

• nausea and vomiting;
• heartburn;
• unstable stool, diarrhea is possible;
• skin itching;
• rashes on the body;
• weakness of the whole body (lethargy);
• dizziness;
• drowsiness;
• loss of appetite;
• violation of color perception;
• thrombus formation.

Solution for infusion (intravenous and intramuscular injection) can cause the following undesirable effects:

• allergies in the form of:
  • rashes;
  • urticaria;
  • skin itching;
• dyspeptic reactions (violation normal function organs of the gastrointestinal tract, difficult and / or painful digestion):
  • anorexia;
  • diarrhea
  • nausea;
• tachycardia;
• pain in the chest area;
• hypotension;
• blurred vision;
• dizziness.

Instructions for use of tablets and solution

Tranexam tablets are taken orally (by mouth) 3-4 times a day. Dosages and duration of treatment are determined by the doctor in accordance with the diagnosed disease. Usually the duration of the course is no more than two weeks. Therapy is carried out under the supervision of medical staff, independent use is prohibited.

The solution for infusion is administered drip or jet. The dose calculation is made by a specialist. Sometimes a single application is enough. The maximum duration of treatment is three days.

Traneksam's analogs

There are structural and pharmacological analogues of this drug. Those drugs that basically have the same active substance have similar effects and contraindications to Tranexam:

• Exacil;
• Troxaminate;
• Traxara;
• Cyclocapron.

What can replace the drug - table

The composition of the drug includes the active ingredient: tranexamic acid.

Additional components of the drug in tablets: MCC, talc, hyprolose, calcium stearate, sodium carboxymethyl starch, colloidal silicon dioxide, macrogol.

Excipient solution for injection into a vein: water for injection.

Release form

Tranexam is produced in the form of tablets and solution for injection into a vein. Tablets containing active component 250 and 500 mg are packaged in contour cells of 10 pieces, 1, 2, 3, 5 cells per package.

The solution for administration is packaged in 50 ml ampoules, 5 pieces in contour cells, 1-2 in a package.

pharmachologic effect

Tranexam solution and tablets have antifibrinolytic, hemostatic, antiallergic and anti-inflammatory action.

Pharmacodynamics and pharmacokinetics

The main component of this drug, tranexamic acid, is an antifibrinolytic agent that inhibits the activity profibrinolysin or plasminogen , contributing to its subsequent transformation into fibrinolysin or plasmin. At the same time, a local and systemic hemostatic effect is manifested, which is necessary for bleeding, which causes a high content fibrinolysis, characteristic of pathology and menorrhagia.

Also noted anti-inflammatory, anti-allergic, anti-infective and antitumor an action that is provided due to the suppression of the production of kinins and other active peptides involved in inflammatory and allergic processes. Tranexamic acid has its own analgesic effect, but also stimulates the analgesic activity of opiates.

Inside the body, the drug undergoes moderate absorption, slightly binding to plasma proteins. The main substance is evenly distributed in the tissues, penetrates the placental barrier, enters breast milk. Also, the drug can be found in seminal fluid, which reduces fibrinolytic activity without affecting the movement of spermatozoa. Preservation of antifibrinolytic concentration in the tissues of the body is 17 hours, and in plasma - about 7-8 hours. It is only slightly affected. The drug is excreted from the body with the help of the kidneys for 12 hours.

Indications for use

The main indications for the use of Tranexam tablets are bleeding or the likelihood of their development due to:

• increased fibrinolysis of local manifestations, that is, uterine, nasal, gastrointestinal tract, hematuria, dental, gynecological, and so on;
• enhancement of generalized fibrinolysis, namely due to the appearance malignant neoplasms in the area of ​​the pancreas or prostate, surgical interventions on the chest, , postpartum hemorrhage, liver diseases;
• hereditary , allergic diseases , such as: , rashes and irritation;
• bleeding with;
• inflammatory diseases such as: , .

• bleeding or the likelihood of their development due to increased various fibrinolysis;
• surgical interventions on the bladder;
• operations for systemic inflammatory reactions, For example, sepsis, peritonitis, pancreatic necrosis, heavy and moderate, various shock states etc.

Contraindications

The use of the drug is contraindicated in:

• subarachnoid hemorrhage;
• high sensitivity to it.

Caution is required in the treatment of patients with thrombosis and the threat of their occurrence, thrombohemorrhagic complications, disorders color vision, hematuria from the upper urinary system, .

Side effects

Side effects may occur during treatment with this drug. So, taking hemostatic pills, you can feel nausea, vomiting, , , rashes, lowering, and. Also, a violation of color perception is not excluded, in rare cases there is - thromboembolism and.

As for the solution for injection into a vein, as a result of its use, the development of dyspepsia, dizziness, weakness, drowsiness, chest pain, hypotension, color vision disorders, blurriness is possible visual perception, thrombosis or thromboembolism and so on.

Instructions for use Tranexam (Method and dosage)

As a rule, Tranexam tablets are recommended to be taken orally.

The dosage and treatment regimen for various disorders is set by the attending physician, although there are standard prescriptions.

For example, the treatment of local fibrinolysis is carried out with the appointment of 1000-1500 mg to 2-3 times a day.

Therapy of profuse uterine bleeding includes taking the drug in daily dosage 1000-1500 mg to 3-4 times a day for 3-4 days.

After surgical intervention Cervical conization tablets are taken in a daily dosage of 1500 mg for a 3-time intake, on average, 12-14 days.

A solution of the drug or Tranexam ampoule instructions for use recommends injecting into a vein. This should be done drip or jet. For each indication, the doctor prescribes certain dosage and duration of use. Therefore, the dose and duration of the drug during menstruation differs, for example, from prescriptions for the treatment of generalized fibrinolysis. There are also various situations, in which dosage adjustment may be required already during the treatment period.

Tranexam during menstruation

It should be noted that disorders menstrual cycle occur quite frequently. It can be intense pain heavy bleeding, cycle date failures. All this is not only unpleasant, but often is the development of various disorders: inflammation, , , infections of the pelvic organs. At the same time, many women undergo thorough examinations and receive a doctor's prescription. In general, there are many hemostatic drugs. As reviews of Tranexam show, during menstruation it is prescribed in the form of tablets. The instructions for the drug contain information about the dosage and duration of therapy - one tablet for 3-4 times a day for 3-4 days.

Tranexam for uterine bleeding

There are many known cases where uterine bleeding caused iron deficiency, which is also a threat to human health and life. Therefore, with uterine bleeding, hemostatic tablets are prescribed, including Tranexam. Of course, this should not be done without a doctor's prescription, since it is important to establish the causes of the violation, which can be very different.

Overdose

Information on overdose is not provided.

Interaction

The use with hemostatic drugs and hemocoagulase can stimulate the activity of thrombosis.

Solution for injection into a vein has pharmaceutical incompatibility with drugs, some solutions, which include , urokinase, diazepam, , some hypertensive drugs, for example, norepinephrine, metharmina bitartrate and Deoxyepinephrine hydrochloride.

special instructions

Prior to the start of the therapeutic process, an examination by an ophthalmologist should be carried out in order to determine visual acuity, examination of the eye fundus and color perception.

Terms of sale

On prescription.

Storage conditions

No storage space required special conditions. For this, it is important that it is inaccessible to children, at temperatures up to 30 C.

Shelf life

Tranexam during pregnancy and lactation

This drug may be prescribed for bleeding during pregnancy. Of course, you need to take the medicine only according to indications, taking into account all contraindications. It is known that the main substance easily overcomes the placental barrier and enters breast milk. However, reviews of Tranexam from women who took this drug contain information that the treatment went without complications.

Treatment of bleeding during pregnancy takes place with the appointment of the drug in a daily dosage of 250-500 mg for 3-4 times a day. The medicine is taken until the bleeding stops completely, but usually the therapeutic course lasts 7 days.

Traneksam's analogs

Coincidence in the ATX code of the 4th level:

The main analogues of Tranexam: Tugina, Aminocaproic acid, Trenax and .

Alcohol and Tranexam

It is forbidden to take alcohol during the treatment period, as it has an undesirable effect on the state of the blood.