"Arcoxia": reviews of doctors. Anti-inflammatory agent "Arcoxia": price, analogues and contraindications

Etoricoxib is a selective inhibitor of inducible cyclooxygenase (COX-2). In a therapeutic dosage, it prevents the production of prostaglandins and arachidonic acid. Inhibition of enzymes involved in the biosynthesis of inflammatory mediators is accompanied by a decrease in the severity of inflammatory reactions in tissues.

According to clinical tests, Arcoxia does not affect the function of the gastrointestinal mucosa and blood plates (platelets). At the same time, etoricoxib does not affect the biosynthesis of constructive cyclooxygenase, which stimulates the transformation of arachidonic acid into prostacyclins. In the course of studies, the effect of NSAIDs on the rate of platelet aggregation provoked by collagen was not established.

The therapeutically active components of the anesthetic drug are rapidly absorbed into the bloodstream through the walls of the gastrointestinal tract. The bioavailability of etoricoxib when taken orally is 99-100%. The maximum rate of reaching the peak concentration of metabolites in plasma is 60 minutes when taking at least 120 mg.

Eating practically does not affect the intensity of absorption of NSAID components. Parallel application antacids does not affect the pharmacokinetic properties of the drug.

Upon penetration into the blood, etoricoxib binds to albumin by at least 92-95%. In the case of taking 120 mg of the drug, the volume of redistribution of active substances in the equilibrium state is 125 liters. It is known that the active metabolites of NSAIDs penetrate the hematoplacental and blood-brain barrier.

Under the influence of cytochrome P450 isoenzymes, etoricoxib is metabolized in the parenchyma to 6-hydroxymethyl-etoricoxib. No more than 1% of the active substances are excreted unchanged by the kidneys. Etoricoxib is cleaved to 5 different metabolites, most of which do not affect COX-1 and have low activity against inducible cyclooxygenase.

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Description of the drug

Arcoxia is a non-steroidal anti-inflammatory drug with antipyretic, analgesic properties. The drug belongs to the group of selective cyclooxygenesis agents. It is used to treat diseases of the articular tissue. Arcoxia contains components that control the formation of substances in the body that are responsible for the development of pain and inflammation.

The active substance of the drug is etoricoxib. Additional components include: calcium hydrogen phosphate, magnesium stearate, microcrystalline cellulose, croscarmellose sodium.

Arcoxia prevents severe pain in the joints, is used for the course treatment of movable bone joints, acts gradually. If it is necessary to stop the attack and instantly alleviate the condition, the single dose is increased.

Indications for use: gouty arthritis in the acute phase, osteoarthritis, rheumatoid forms of joint inflammation, ankylosing spondylitis. In addition, doctors recommend using the medicine for soft tissue damage, as it relieves constant pain.

Arcoxia - potent medical device, which should not be taken by people with high sensitivity to the constituent components, in the presence of polyps in the nasal sinuses, frequent bleeding (poor clotting), bronchial asthma (history), inflammatory processes in the digestive tract, intolerance to NSAIDs. Other contraindications to the use of the drug are: hypertension, vascular pathologies, cardiac, hepatic, renal failure, pregnancy, lactation, age up to 16 years.

Can Arcoxia be taken by people suffering from alcoholism?

No. Anti-inflammatory drug and alcohol are incompatible.

Dosing regimen

The medicine is taken orally, regardless of the meal. With osteoporosis daily dose the drug should not exceed 60 mg per day, ankylosing spondylitis and rheumatoid arthritis - 90 mg, gouty arthritis in the acute phase - 120 mg. daily rate and the duration of treatment is prescribed by the doctor based on the state of health of the patient. With pain syndrome, the average therapeutic dose is 60 mg once.

In view of the extensive list of side effects and available contraindications, Arcoxia is not recommended for use without a detailed diagnosis of the state of health. In addition, it is forbidden to increase the dosage of the drug more than 120 mg. Violation of the course of admission helps to reduce the effect of its action.

In case of overdose or use of the drug in the presence of contraindications, there is backlash from the body.

Side effects (consequences):

Sensory disturbances.
Ulcers on the mucous membrane of the mouth, digestive organs, vomiting, flatulence, diarrhea.
Drowsiness, dizziness, hallucinations, tinnitus, weakness.
Decrease in platelets and leukocytes, hemoglobin (hematocrit).
Bronchial spasms, shortness of breath, cough, infections respiratory organs, nose bleed.
Violations of the heart and kidneys, jumps in blood pressure, hypertensive crisis, heart attack.
Proteinuria, an infection of the bladder.
Skin itching, urticaria, weight gain, muscle cramps.

The effectiveness of Arcoxia 60 increases with the simultaneous use of acetylsalicylic acid and antiviral tablets. Full course therapy helps to eliminate all signs of joint pathology, restore blood circulation and metabolic processes in tissues. In order to consolidate the result drug treatment should be supplemented with physiotherapy, exercise therapy.

What are the analogues of Arcoxia?

Ibuprofen, Cifecon, Dilaxa.

For safety reasons, it is not recommended to select the drug on your own. Self-medication is dangerous to health. The correct choice of a drug with similar therapeutic properties is best left to the attending physician. Otherwise, the result of the course of therapy may be unfavorable.

Arcoxia drug compatibility

Taking an anti-inflammatory drug is not recommended to be combined with Warfarin, because in the process of interaction, drugs increase the INR of prothrombin time by 13%.

Nonsteroidal drugs(non-selective and selective) give negative compatibility with diuretic drugs and ACE inhibitors, since they weaken their effect. In case of problems with the organs of the urinary system, this tandem can lead to aggravation kidney failure. While taking Arcoxia with Cyclosporine or Tacrolimus, the risk of a nephrotoxic effect increases, and with Rifampicin, the amount of etoricoxib in plasma decreases by 65%.

Remember, in the process of using the drug, it is important to comply with the dosage prescribed by the attending physician, otherwise you can harm your health.

Arcoxia and alcohol

Non-steroidal anti-inflammatory drugs, as well as non-narcotic analgesics, are forbidden to be used simultaneously with alcoholic beverages. In the case of the interaction of Arcoxia 90, 60, 30, 120 with alcohol, the toxic effect of the drug increases, turning it into a poison for the body. As a result, metabolites are formed that damage the liver and ulcers on the mucous membrane of the digestive tract. The higher the dosage of the active substance of the drug (etoricoxib) and the more alcohol is taken, the more pronounced side effects from the body.

Remember, from the moment alcohol enters the stomach, each cell begins to work on its utilization. If at the moment there are still present in the body medicines the load on the internal organs increases many times, which forces the liver to break down the incoming substances in an accelerated mode, to function for wear and tear.

When deciding to drink alcoholic beverages during anti-inflammatory therapy, it should be borne in mind that with such a load, it will not last long. In addition, alcohol destroys brain cells, which leads to oxygen starvation and a lack of nutrients, respectively. As a result, coordination of movements, speech is disturbed, severe headaches occur, sleep disturbance, gastrointestinal tract work are observed, a person may be in a hallucinatory state. The liquid begins to linger in the layers of tissue. The metabolic process is disrupted and water-salt balance in organism.

People suffering from stomach ulcers or gastritis should be especially careful, since the interaction "Arcoxia-alcohol" leads to an exacerbation of the course of the disease, which threatens internal bleeding. In addition, this combination increases the risk of developing myocardial infarction, cardiovascular insufficiency, and hypertensive crisis.

The duration of the therapeutic effect of the active substance Arcoxia in the body is a day. Therefore, if there is a desire to drink alcohol, it is necessary to wait a safe period of time - 24 hours after the last dose of the drug.

Conclusion

Arcoxia is a non-steroidal drug intended for the treatment of inflammatory processes in the body. The drug is produced in four dosage variations (30, 60, 90, 120 mg). After entering the gastrointestinal tract, the drug begins to act within 30 minutes and retains its effect for 24 hours.

Arcoxia is used to treat gouty arthritis, primary dysmenorrhea, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis. It has analgesic, antipyretic, anti-inflammatory effects, reduces the level of prostaglandins in areas of tissue inflammation.

The combination with alcohol makes the drinker fully responsible for the resulting consequences: flatulence, kidney failure, hypertensive crisis, heart attack, digestive tract disorders, impaired normal blood circulation. Etoricoxib, which is part of the drug, increases the load on the liver and kidneys, which triples under the influence of ethyl-containing drinks. Therefore, in the case of treatment with non-steroidal anti-inflammatory drugs, you should refrain from drinking hot cocktails during the course of therapy, otherwise you can experience the effect of the proverb from your own experience: “you treat one thing - you cripple another”.

If there is a predisposition to alcohol consumption (dependence), this habit should be without fail notify the doctor in advance in order to adjust the treatment regimen. Always be vigilant when we are talking about the health of a loved one.

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A few words about Arcoxia

Available in the form of tablets and ampoules with solutions. Manufacturers did not provide for the gel-like form and ointment. Tablets are made in the form of an apple.

As a substance active action is etoricoxib. It is a selective inhibitor with a depressant effect on prostaglandins responsible for various inflammations. In addition to the anti-inflammatory effect, etoricoxib is able to anesthetize and reduce fever. The main advantage of the drug is the absence of effects on the gastrointestinal mucosa and the processes of platelet adhesion.

The medicine should be taken orally. There are no specific conditions regarding the intake of food. If you follow the dosage indicated in the instructions, food will not affect the rate of absorption of the substance and its effect on the body.

The instructions for the drug contain more than one name of possible complications. Due to the fact that alcohol itself often gives similar negative manifestations, it is worth mentioning them. Moreover, under the influence of alcohol, all side effects of drugs are enhanced. The drug in question has:

Pain in the head.
General weakness in the body.
Nausea and heartburn.
Bleeding from the nose.
Violation of concentration.
Influenza and others.

The interaction of Arcoxia and ethyl alcohol

The description of the drug contains information on whether Arcoxia and alcohol-containing drinks are compatible or not. Representatives from the pharmaceutical industry warn that in such situations, taking pills should be accompanied by extreme caution. However, this does not mean at all that it is permissible to drink alcohol-containing drinks at the same time. This warning only preserves the right of man to decide for himself.

The compatibility of Arcoxia and alcohol can be understood by studying in detail the list of contraindications and side effects. So, its action is a day. This suggests that within 24 hours the active substance etoricoxib will be in the body and affect various processes.
The combination of the drug with ethyl alcohol at this time can cause any negative consequence. We can assume the following complications, based on the reviews of doctors about the pills:

Poisoning the body with ethanol

From poisoning, dysfunction of all organs occurs. As soon as ethanol is in the blood, the body begins to act to destroy it. And if at the same time the effect of the drug is added, the load on the body increases several times. Although the description of the tablets does not say anything about this, it can be predicted that side effects from the tablets will be added to the destructive effect of alcohol. Such repeated stress is not easy for the body to endure. Significant interruptions are likely, provoked by destructive processes. If alcoholism is added to the overall picture, the consequences can be even more devastating.

Liver dysfunction

Since in the process of taking Arcoxia, the iron experiences a double load. Metabolism of the drug substance occurs directly in it. Two processes will be carried out in the gland at one moment: the processing of the medicine and the fight against the harmful components of alcohol. A healthy organ will probably be able to work for some time without interruption. But a weak gland is likely to suffer significantly.

Cell damage in the brain

A complete supply of cells with oxygen molecules and nutrients supplied with blood is destroyed. There is intoxication with concomitant pain in the head, dizziness, impaired coordination and speech. With the joint use of Arcoxia with alcoholic beverages, these negative effects may intensify, since the tablets have almost the same side effects. Hallucinations, drowsiness and confusion are also likely.

Malfunctions in the functions of the gastrointestinal tract

Under the influence of alcohol functioning gastrointestinal tract is violated. Various disorders or diarrhea occur. The drug in question also has similar side effects: the same thing is aggravated by nausea, bloating, exacerbations of gastritis and ulcers duodenum.

Kidney dysfunction

Manifested as a result of vigorous activity to remove the elements of the decay of ethyl alcohol. This function occurs with a complication due to the action of the drug. Among side effects there is also kidney failure from Arcoxia. There is an increased likelihood of aggravation of the present pathologies of the organ or the launch of processes upon their occurrence.

Violation of metabolic processes

This includes water retention. The use of pills and alcohol at the same time can increase these manifestations. The drug also provokes metabolic disorders and water balance in the body, appetite.

Listed negative effects from the joint intake of pills and alcohol-containing drinks - not at all exhaustive. This can also include the likelihood of myocardial infarction, cardiovascular insufficiency, increased blood pressure. Allergies are quite common.

Therefore, combining pills and booze is a risky business. Although the description of side effects from alcohol intake, scant information is given, it does not follow from this that simultaneous reception Arcoxia and ethyl alcohol are not dangerous. Each person's body is unique, and the consequences will be individual. There is a possibility that small dose alcoholic beverage will cause severe complications and the need for long-term treatment.

Rules for taking alcohol after Arcoxia

When taking Arcoxia, the liver is exposed to the greatest stress. Despite good reviews about it, the drug has many contraindications.

It must be remembered that directly in the liver, the substance is broken down into individual components. If you drink alcohol at the same time, the load on the gland will increase significantly, and toxic substances from alcohol will quickly spread throughout the body.

Therefore, deciding on the use of such drinks while taking the medicine, first of all, you should assess the condition of your liver. Moreover, it must be remembered that even the healthiest organ will not withstand such loads for a long time. Also, one should not forget about the duration of the drug. It is better to wait until the end of this period, and only then drink the drink. It will be more secure.

But in general, it is allowed to start taking pills only after the complete removal of ethanol from the blood. This period varies from 30 minutes to several days, and depends on the volume of the drink and the strength of the drink.

Below is information about the co-administration of Arcoxia and drinks containing ethyl alcohol.

We are allowed to accept:

18 hours before drinking alcohol and 8 hours after - for men;
one day before and not earlier than 14 hours after - women

In order to avoid health risks, it is better to give up alcohol for the entire duration of treatment.

In any case, the person himself is responsible for the consequences of taking Arcoxia along with alcohol-containing liquids. Given the enormous burden on the liver, kidneys and other organs, this is highly discouraged.

Since the doctor usually monitors the patient's blood pressure during the course of treatment, it is the responsibility of the latter to notify the doctor about the recent drinking of alcohol. After all, it provides direct influence to the BP level. The most detailed monitoring of blood pressure is carried out during the first 14 days. In addition, liver and kidney health, as well as enzyme levels, are often assessed. In this regard, any deviations from the normative values are perceived by the doctor as the result of the influence of the medication taken.

What do the doctor's say?

Reviews of doctors about Arcoxia are mostly positive. This non-hormonal remedy Works great for many inflammations in the body. However, reviews about the use of the drug in conjunction with alcohol are unequivocally negative. In this case, a double blow to the liver is guaranteed, the doctors are sure.

The drug is broken down in this organ to final metabolites, therefore, it can adversely affect liver function - especially if hepatitis or other serious diseases are present.

If for any reason you have consumed Arcoxia and alcohol, take the following steps:

stop further intake of alcoholic beverages;
in the next four hours, drink as much clean water as possible;
study in detail the contraindications in the instructions for the tablets and subsequently take them into account;
in a situation of course administration of the drug, it is impossible to drink alcohol categorically for a period of three days to a month ( exact time abstinence will be determined by the doctor).

It should be remembered that regardless of the form of the drug taken, the side effects when combined with alcohol will be identical. Although, if this happened for the first time, the risk to health will be minimal, but it is better not to allow such situations. In difficult situations, you should seek the advice of a doctor.

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The composition and form of release of the drug

Biconvex tablets of an interesting apple-shaped form, film-coated - it is in this form that the Arcoxia drug is produced. Injections, oral solutions, gels, ointments - these forms of the drug do not exist.

The main active ingredient of the drug is etoricoxib. By the way, the drugstore sells pills different color depending on the amount of active substance, they can be green (60 mg etoricoxib), white (90 mg) or light green (120 mg).

Naturally, some auxiliary components are also present in the composition: magnesium stearate, calcium hydrogen phosphate, croscarmellose sodium and microcrystalline cellulose. The film coating consists of carnauba wax, hypromellose, titanium dioxide, lactose monohydrate, triacetin, aluminum varnish based on indigo carmine and, of course, the main dyes (Opadry white or green, depending on the dosage).

Tablets are placed in convenient blisters of seven pieces. In a pharmacy, you can buy packages with one or three of these blisters.

Main pharmacological properties

This medicine belongs to the group of non-steroidal anti-inflammatory drugs. Etoricoxib is a substance that selectively inhibits COX-2, which, in turn, prevents the synthesis of prostaglandins, blocking the development of the inflammatory process. The drug "Arcoxia" also has a pronounced analgesic and antipyretic effect, but it does not affect the mucous membrane of the digestive system and the functioning of platelets.

After taking the drug is rapidly absorbed, its bioavailability is 100%. The maximum concentration in the blood is observed after 1 hour. The active ingredient binds to plasma proteins by more than 92%. It is excreted from the body mainly through the kidneys, and only 20% of the substances are excreted with feces.

Indications for use

When is it advisable to take Arcoxia? Its use is quite wide, as it provides a quick analgesic effect, and also allows you to eliminate the inflammatory process. However, most often the drug is prescribed to patients suffering from osteoarthritis and rheumatoid arthritis. Indications for use are also pain caused by gouty arthritis and ankylosing spondylitis. In some cases, tablets are recommended for people who have recently undergone dental surgery.

The drug "Arcoxia" (tablets): instructions for use and dosage

In no case should you use this drug on your own. Only a doctor can prescribe and tell you how to properly take Arcoxia (tablets). The manual contains only general recommendations.

The dosage generally depends on the patient's condition and the type of problem. For example, in osteoarthritis, it is most often recommended to take one tablet with a dosage of 60 mg per day, regardless of the meal. The maximum daily dose for patients with spondylitis and rheumatoid arthritis is 90 mg of the active substance. For gouty arthritis, you can take 120 mg per day. The duration of therapy is determined by the attending physician. However, the maximum allowable period treatment is 8-10 days, after which the reception should be stopped at least for a while.

With caution, the drug is prescribed to people suffering from liver failure - the daily dose in such cases should not exceed 60 mg.

Are there contraindications?

Immediately it should be said that this drug can not be taken by all categories of patients. The drug has contraindications, the list of which must be read before taking:

hypersensitivity to the components of the drug, as well as other non-steroidal anti-inflammatory drugs, especially in patients suffering from bronchial asthma and nasal polyposis;
erosive and ulcerative lesions of the mucous membrane of the digestive tract, gastrointestinal bleeding;
inflammatory bowel disease, including ulcerative colitis and Crohn's disease;
bleeding disorders, including hemophilia;
severe heart failure;
severe forms of renal and hepatic insufficiency;
severe ischemic heart disease;
the period after coronary artery bypass grafting;
persistent arterial hypertension;
children's age (the drug is not prescribed for children under 16 years of age);
pregnancy, lactation, as well as the period of pregnancy planning.

The drug also has some relative contraindications, in which therapy is possible, but only with the constant supervision of the attending physician. With caution, the drug is prescribed to patients suffering from fluid retention in the body, as well as severe somatic diseases, hypertension and diabetes mellitus. The medicine also cannot be combined with alcohol.

Side effects

Many patients ask the question of what complications can lead to taking the drug "Arcoxia". Reviews of doctors indicate that patients who took pills rarely complain of any deterioration. However, adverse reactions are possible. For example, during therapy, an allergic reaction may occur, sometimes even anaphylactic shock. Some patients noted the appearance of nausea, abdominal pain, diarrhea, bloating, belching, dry mouth.

Other possible side effects include headaches, weakness, confusion, sleep disturbances, anxiety, trouble concentrating, depressive states, blurred vision, vertigo, tinnitus.

Sometimes there are violations respiratory system, in particular cough, as well as nosebleeds. The drug can affect the cardiovascular system, causing an increase in pressure, palpitations, extremely rarely - congestion, circulatory disorders of the brain, hypertensive crisis, myocardial infarction. In some patients, the drug increases the likelihood of developing infectious diseases respiratory and digestive systems.

Overdose: symptoms and treatments

Is it possible to overdose the drug "Arcoxia". Reviews of doctors and statistical studies indicate that such cases have not been officially registered. Even a single dose of 500 mg of the active substance, as well as the use of small doses of the drug for three weeks, are not accompanied by serious complications. An overdose may cause an aggravation of the present side effects from the cardiovascular and digestive systems. Therapy in this case is symptomatic and is aimed at eliminating existing disorders.

Interaction with other drugs

While taking Arcoxia and anticoagulants, you need to carefully monitor the international normalized ratio (INR) - the ratio of prothrombin time this patient to the mean prothrombin time - especially in the first few days of therapy.

Simultaneous reception this medicine with large doses of acetylsalicylic acid increases the risk of ulcerative lesions of the mucous membrane of the digestive tract. Simultaneous therapy with tacrolimus and cyclosporins increases the likelihood of nephrotoxicity.

The drug can interact with some oral contraceptives, increasing the risk of developing thromboembolism, so be sure to tell your doctor about the hormones you are taking before starting therapy - they may need to be replaced.

Arcoxia tablets: analogues and substitutes

Not every patient for one reason or another is suitable for this drug. Therefore, many people are interested in the question of what can replace the drug "Arcoxia". Analogues of this tool exist, and there are quite a few of them.

For example, if we are talking about pain relief, then non-steroidal anti-inflammatory drugs such as Ibuprofen, Nurofen, Diclofenac (by the way, it is also available in the form of a gel for external use), Ketonal and many others are considered quite popular.

And if you suffer from osteoporosis and other diseases of the musculoskeletal system, then you can choose another substitute. Arcoxia is often replaced by drugs such as Ostalon, Alendros, Ost, Lindron. But remember that only the attending physician can choose an analogue. Doing it yourself is strictly contraindicated.

How much does the medicine cost?

Many patients are interested in the question of how much the drug "Arcoxia" costs. The price, of course, will depend on several factors. In particular, it is necessary to take into account the city of residence, pricing policy pharmacies, manufacturer, etc.

So how much will the medicine "Arcoxia" cost? The price of a package of seven 60 mg tablets ranges from 350 to 450 rubles. Three blisters will cost about 1100 rubles. Dosage is another factor on which the cost of Arcoxia depends. Tablets of 90 mg cost about 550 rubles for seven pieces. For a package of three blisters, you need to pay about 1300-1400 rubles. Seven tablets with 120 mg of the active ingredient cost about 700 rubles.

Reviews of specialists and patients

Of course, many patients are interested in the question of what experts think about the drug Arcoxia. Reviews of doctors are mostly positive. The fact is that the pills really relieve the pain. Moreover, they inhibit the development of the inflammatory process and help normalize body temperature during fever. In addition, the pills are not as damaging to the liver and digestive system as some other non-steroidal anti-inflammatory drugs. On the other hand, not every patient can take the drug, since there are relatively many contraindications.

Patients for the most part also respond positively to the drug. This tool actually relieves the condition and relieves soreness, while acting almost throughout the day. Most often, one tablet per day is enough, which is very convenient. Some people have contraindications or side effects, but it is worthwhile to understand that the body's reaction to certain drugs is individual. The disadvantages include the high cost, which not everyone can afford. On the other hand, one blister is usually enough for the entire course of treatment.

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In this article, you can read the instructions for using the drug Arcoxia. Reviews of site visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Arcoxia in their practice are presented. We kindly ask you to actively add your reviews about the drug: the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not declared by the manufacturer in the annotation. Analogues of Arcoxia in the presence of existing structural analogues. Use for the treatment of arthrosis and arthritis in adults, children, as well as during pregnancy and lactation. The composition and interaction of the drug with alcohol.

Arcoxia- non-steroidal anti-inflammatory drug (NSAID). Selective inhibitor of COX-2, at therapeutic concentrations, blocks the formation of prostaglandins and has anti-inflammatory, analgesic and antipyretic effects. Selective inhibition of COX-2 is accompanied by a decrease in the severity of clinical symptoms associated with the inflammatory process, while there is no effect on platelet function and the gastrointestinal mucosa.

Etoricoxib (the active substance of Arcoxia) has a dose-dependent effect of COX-2 inhibition, without affecting COX-1 when used in a daily dose of up to 150 mg. Arcoxia does not affect the production of prostaglandins in the gastric mucosa and the bleeding time. In the studies conducted, there was no decrease in the level of arachidonic acid and platelet aggregation caused by collagen.

Compound

Etoricoxib + excipients.

Pharmacokinetics

After oral administration, it is rapidly absorbed from the gastrointestinal tract. Bioavailability when taken orally is about 100%. Eating does not significantly affect the severity and rate of absorption of etoricoxib when taken at a dose of 120 mg. Taking antacids does not affect the pharmacokinetics of the drug. Etoricoxib crosses the placental barrier and the blood-brain barrier (BBB). Intensively metabolized in the liver, with the participation of the cytochrome P450 isoenzyme (CYP) and the formation of 6-hydroxymethyl-etoricoxib. Excretion of etoricoxib occurs as metabolites by the kidneys. Less than 1% of the drug is excreted in the urine unchanged.

There are no pharmacokinetic differences between men and women.

Pharmacokinetics in the elderly (65 years and older) is comparable to that in the young, and there is no need to adjust the dose of the drug in the elderly.

The pharmacokinetic parameters of etoricoxib have not been studied in children under 12 years of age. In comparative pharmacokinetic studies, comparable data were obtained with the use of etoricoxib in a group of adolescents (from 12 to 17 years old) weighing 40-60 kg at a dose of 60 mg per day, in a similar age group and with a body weight of more than 60 kg - 90 mg per day, and in adults when taking 90 mg per day.

Indications

Symptomatic therapy of the following diseases and conditions:

osteoarthritis;
rheumatoid arthritis;
ankylosing spondylitis;
pain and inflammatory symptoms associated with acute gouty arthritis;
moderate to severe therapy acute pain after dental operations.

Release form

Film-coated tablets 30 mg, 60 mg, 90 mg and 120 mg.

Other dosage forms, be it injections in ampoules, ointment or gel, does not exist.

Instructions for use and dosing regimen

The drug is taken orally, regardless of food intake, with a small amount of water.

In rheumatoid arthritis and ankylosing spondylitis, the recommended dose is 90 mg 1 time per day. The daily dose for rheumatoid arthritis and ankylosing spondylitis should not exceed 90 mg.

The duration of use of the drug at a dose of 120 mg is no more than 8 days. The lowest effective dose should be used for the shortest possible course.

The average therapeutic dose for pain syndrome is 60 mg once.

Acute pain after dental surgery: the recommended dose is 90 mg 1 time per day. In the treatment of acute pain, Arcoxia should only be used during the acute symptomatic period, limited to no more than 8 days. The daily dose for pain relief after dental surgery should not exceed 90 mg.

In patients with hepatic insufficiency (5-9 points on the Child-Pugh scale), it is recommended not to exceed a daily dose of 60 mg.

Side effect

epigastric pain;
nausea, vomiting;
diarrhea;
dyspepsia;
flatulence;
bloating;
belching;
increased peristalsis;
constipation;
dryness of the oral mucosa;
gastritis;
ulcer of the mucous membrane of the stomach or duodenum;
irritable bowel syndrome;
esophagitis;
ulcers of the oral mucosa;
gastrointestinal ulcers (with bleeding or perforation);
headache;
dizziness;
weakness;
taste disorder;
drowsiness;
sleep disorders;
sensitivity disorders, incl. paresthesia/hyperesthesia;
anxiety;
depression;
hallucinations;
confusion;
blurred vision;
conjunctivitis;
noise in ears;
renal failure, usually reversible when the drug is discontinued;
anaphylactic / anaphylactoid reactions, including a pronounced decrease in blood pressure and shock;
heartbeat;
increase in blood pressure;
hot flashes;
violation cerebral circulation;
atrial fibrillation;
congestive heart failure;
hypertensive crisis;
cough;
dyspnea;
nose bleed;
bronchospasm;
swelling of the face;
skin itching;
rash;
hives;
Stevens-Johnson syndrome;
Lyell's syndrome;
infections of the upper respiratory tract, urinary tract;
muscle cramps;
arthralgia;
myalgia;
swelling, fluid retention;
appetite changes;
weight gain;
leukopenia, thrombocytopenia;
flu-like syndrome;
pain in the chest.

Contraindications

complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including history);
erosive and ulcerative changes in the mucous membrane of the stomach or duodenum, active gastrointestinal bleeding, cerebrovascular or other bleeding;
inflammatory bowel disease (Crohn's disease, ulcerative colitis) in the acute phase;
hemophilia and other bleeding disorders;
severe heart failure (2-4 functional classes according to the NYHA classification);
severe liver failure (more than 9 points on the Child-Pugh scale) or active liver disease;
severe renal failure (CC less than 30 ml / min), progressive kidney disease, confirmed hyperkalemia;
the period after coronary artery bypass grafting; diseases of peripheral arteries, cerebrovascular diseases, clinically expressed ischemic heart disease;
persistent blood pressure values exceeding 140/90 mm Hg. Art. with uncontrolled arterial hypertension;
pregnancy;
lactation period (breastfeeding);
children's age up to 16 years;
hypersensitivity to any component of the drug.

Use during pregnancy and lactation

The drug is contraindicated during pregnancy and lactation.

The use of the drug may adversely affect female fertility and is not recommended for women planning a pregnancy.

Use in children

Contraindicated in children and adolescents under the age of 16 years.

special instructions

Taking the drug Arcoxia requires careful monitoring of blood pressure. When prescribing the drug, all patients should monitor blood pressure during the first two weeks of treatment and periodically thereafter.

You should also regularly monitor liver and kidney function.

In case of an increase in the level of hepatic transaminases by 3 times or more relative to ULN, the drug should be discontinued.

Given the increased risk of adverse effects with increasing duration of administration, it is necessary to periodically evaluate the need to continue taking the drug and the possibility of reducing the dose.

Do not use the drug simultaneously with other non-steroidal anti-inflammatory drugs.

Use the drug with caution if you drink alcohol often.

The shell of the drug Arcoxia contains lactose in a small amount, which should be taken into account when prescribing the drug to patients with lactase deficiency.

Influence on the ability to drive vehicles and control mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration attention and speed of psychomotor reactions. Patients who have experienced episodes of dizziness, drowsiness or weakness should refrain from activities that require concentration.

drug interaction

Pharmacodynamic interaction

In patients receiving warfarin, taking Arcoxia at a dose of 120 mg per day was accompanied by an increase of approximately 13% in MHO and prothrombin time. In patients receiving warfarin or similar medicinal products, MHO values should be monitored at the time of initiation of therapy or changes in the dosing regimen of Arcoxia, especially in the first few days.

There are reports that non-selective NSAIDs and selective COX-2 inhibitors can weaken the hypotensive effect of ACE inhibitors. This interaction should be taken into account when treating patients taking Arcoxia concomitantly with ACE inhibitors. In patients with impaired renal function (for example, with dehydration or in old age), such a combination may aggravate renal failure.

Arcoxia can be used concomitantly with acetylsalicylic acid in low doses, intended for the prevention of cardiovascular diseases. However, co-administration of low-dose acetylsalicylic acid and Arcoxia may lead to an increased incidence of gastrointestinal ulceration and other complications compared with Arcoxia alone. After reaching a steady state, taking etoricoxib at a dose of 120 mg 1 time per day does not affect the antiplatelet activity of acetylsalicylic acid at low doses (81 mg per day). The drug does not replace the preventive action of acetylsalicylic acid in cardiovascular diseases.

Cyclosporine and tacrolimus increase the risk of developing nephrotoxicity while taking Arcoxia.

Pharmacokinetic interaction

There is evidence that non-selective NSAIDs and selective COX-2 inhibitors can increase the concentration of lithium in plasma. This interaction should be taken into account when treating patients taking Arcoxia concomitantly with lithium.

Two studies examined the effects of Arcoxia 60, 90 and 120 mg once daily for seven days in patients treated with once weekly methotrexate 7.5 to 20 mg for rheumatoid arthritis. Arcoxia at a dose of 60 and 90 mg had no effect on the plasma concentration (according to AUC) and renal clearance of methotrexate. In one study, Arcoxia at a dose of 120 mg had no effect on the plasma concentration (AUC) and renal clearance of methotrexate. In another study, Arcoxia at a dose of 120 mg increased the plasma concentration of methotrexate by 28% (according to AUC) and reduced the renal clearance of methotrexate by 13%. With the simultaneous appointment of Arcoxia in doses above 90 mg per day and methotrexate, monitoring should be carried out for possible appearance toxic effects of methotrexate.

Oral contraceptives: Taking Arcoxia at a dose of 120 mg with oral contraceptives containing 35 mcg of ethinylestradiol and 0.5 to 1 mg of norethindrone for 21 days, simultaneously or with a difference of 12 hours, increases the stationary AUC0-24 of ethinylestradiol by 50-60%. However, the concentration of norethisterone usually does not increase to a clinically significant extent. This increase in the concentration of ethinylestradiol should be taken into account when choosing the appropriate oral contraceptive for simultaneous use with Arcoxia. A similar fact can lead to an increase in the frequency of thromboembolism, due to an increase in the exposure of ethinyl estradiol. No significant pharmacokinetic interaction with GCS was found.

Etoricoxib does not affect steady state AUC0-24 or digoxin elimination. At the same time, etoricoxib increases Cmax (by an average of 33%), which may be important in the development of an overdose of digoxin.

Co-administration of Arcoxia and rifampicin (a potent inducer of hepatic metabolism) resulted in a 65% decrease in plasma etoricoxib AUC. This interaction should be considered when Arcoxia is co-administered with rifampicin.

Antacids and ketoconazole (a potent inhibitor of CYP3A4) do not have a clinically significant effect on the pharmacokinetics of Arcoxia.

Arcoxia's analogues

Arcoxia has no structural analogues for the active substance.

Analogues for the therapeutic effect (remedies for the treatment of arthrosis):

Actasulide;
Alflutop;
Apranax;
Artra;
Artradol;
Artrovit;
Artrotek;
Aulin;
Brufen;
Butadion;
Veral;
Voltaren Emulgel;
Glucosamine sulfate 750;
Dexazon;
Dexamethasone Phosphate;
Diklobene;
Dicloberl;
Dicloran;
Diclofen;
Diclofenac;
Dimexide;
Diprospan;
Long;
DON;
Donalgin;
Zinaxin;
ibuprofen;
Indomethacin;
Kartilag Vitrum;
Ketonal;
Coxib;
Mesulide;
Myolastan;
Movasin;
Naproxen;
Nimesil;
Ortofena;
Piroxicam;
Rheuma gel;
Ronidase;
Rumalon;
Sabelnik Evalar;
Sanaprox;
Tenic;
Tenoctil;
Triamcinolone;
Fastum gel;
Feloran;
Flolid;
Chondramin;
Hondrolon;
Cefekon;
Gypsy;
Unium.

instrukciya-otzyvy.ru

Arcoxia tablets: indications, restrictions on admission and possible complications of therapy

By and large, the drug can be taken with acute pain, accompanied by an inflammatory process.

But in practice, Arcoxia tablets are prescribed for lesions of the musculoskeletal system:

rheumatoid, psoriatic and other types of arthritis;
progressive spondylitis (Bekhterev's disease);
osteoarthritis;
osteochondrosis;
other dorsopathies;
pain after orthopedic surgical interventions(according to international clinical studies).

Arcoxia tablets have a symptomatic effect, in other words, they stop the inflammation and the pain caused by it, but do not affect the etiology of the disease. Therefore, they are prescribed for a different period (the duration of treatment is selected individually) as part of complex therapy with cytostatics, chondroprotectors, physiotherapy procedures.

Contraindications to the appointment of the drug are the following pathologies and conditions:

individual allergic reaction to etoricoxib and auxiliary components of the drug and other NSAIDs;
pregnancy;
lactation;
children under 16 years of age (although studies have been conducted regarding the pharmacodynamics of the drug in adolescents over 12 years of age, during which no negative impact on the body)
a combination of bronchial asthma, sinus polyposis and intolerance to NSAIDs (which is extremely rare);
erosive lesions of the gastrointestinal tract, including peptic ulcer, colitis, Crohn's disease, inflammatory diseases in the acute stage, and even more so bleeding (during remission, the presence of such pathologies requires special care when taking Arcoxia inside);
blood clotting disorders;
severe heart, kidney and liver failure;
severe symptoms of coronary heart disease and atherosclerosis of the main blood vessels;
recovery after coronary artery bypass surgery (due to the risk of bleeding);
uncontrolled bouts of high blood pressure.

Arcoxia tablets are not the first drug from the so-called “coxibs” group.

Previously, the same company released the drug Rofecoxib. In clinical trials at the stage of approbation of the agent Special attention paid attention to its effect on the mucous membrane of the digestive tract and were quite satisfied with the result.

However, over the course of several years of clinical practice, doctors have found that taking Rofecoxib significantly increases the risk of developing complications from of cardio-vascular system.

This led Merck Sharp & Dohme to withdraw the drug from the market in 2004 and discontinue its production. For this reason, the safety of etoricoxib ( generic name Arcoxia) was given great attention. After conducting clinical studies, the risk of developing adverse reactions was compared with that when taking the "classic" NSAID Diclofenac.

As a result of hard work and data analysis medical records hundreds of patients have come to the conclusion that Arcoxia tablets have a much lesser effect on the mucous epithelium of the digestive tract. And the risk of complications from the cardiovascular system is slightly lower than that of Diclofenac.

However, in accordance with international standards, the list of side effects includes all possible adverse reactions, even if their development is only theoretically possible.

According to the information provided by the manufacturer, tablets can lead to the following complications:

disorders of the digestive system, including pain in the epigastrium, stool disorders, flatulence, belching, erosive lesions of the oral mucosa appear extremely sharply, exacerbation of peptic ulcer is possible;
influence on the functioning of the nervous system, which manifests itself in the form of headaches, dizziness, weakness, drowsiness, in isolated cases, anxiety and unreasonable fear, symptoms of depression were noted;
signs of complications from the sensory organs are extremely rare, however, taste disturbance and blurred vision are possible;
violations cardiovascular activity can occur in the form of shortness of breath, tachycardia, increased blood pressure, which is reflected in the electrocardiogram, the onset of a heart attack and attacks of hypertension is theoretically possible;
from the side of various parts of the respiratory tract, coughing is sometimes possible, nosebleeds are noted in isolated patients, and bronchospasm is extremely rare;
due to metabolic disorders, edema occurs, in some cases appetite worsens, or vice versa, weight gain occurs;
skin manifestations of a hypersensitivity reaction (rash, itching, urticaria);
complications of tissue functioning musculoskeletal system can make themselves felt in the form of minor cramps and pain in the muscles.

Also, taking Arcoxia is sometimes accompanied by a general deterioration in well-being (doctors call this condition a flu-like syndrome), an increased risk of developing infections of the urinary and respiratory systems. In addition, Arcoxia tablets can affect the results of a clinical blood test and liver tests, which should be taken into account when deciphering these studies.

Arcoxia: instructions for use and the possibility of combination with other medicines

Due to the peculiarities of the pharmacodynamics of the drug, to achieve a therapeutic effect, the drug can be taken only once a day.

The maximum dosage is 120 mg. Such an amount Arcoxia instruction on application recommends drinking with severe pain arising from psoriatic arthritis.

With osteochondrosis, it is necessary to take 0.6 g per day, for the treatment of rheumatoid arthritis and spondylitis, 0.9 g is prescribed once a day.

As a rule, they drink the medicine regardless of the meal. The duration of therapy in the maximum allowable amount (1.2 g) is no more than 8 days, in other cases, the duration of administration is determined by the doctor. But since all NSAIDs are intended for the symptomatic relief of acute pain syndrome, the use of Arcoxia is stopped after the disappearance of the main clinical manifestations diseases.

To simulate the symptoms of an overdose, the drug was given in a single dose of 500 mg. Another clinical study was conducted with the appointment of Arcoxia, the instructions for use of which clearly describe the method of taking the drug, in an amount of 150 mg per day for 3 weeks. During the tests, symptoms of overdose were not noted.

But doctors warn that exceeding the recommended number of tablets is fraught with unwanted reactions from the digestive and cardiovascular systems. Since there are no specific antidotes, and the removal of the drug by hemodialysis is ineffective, symptomatic therapy is carried out.

When combined with other Arcoxia drugs, the instructions for use advise taking into account the following points:

Anticoagulants. There is a slight increase in the action of these drugs, so this combination requires correction of the dosage of anticoagulants and monitoring of blood coagulation parameters.
Diuretics. When combined with Arcoxia, complications from the excretory system may occur.
Angiotensin-converting enzyme inhibitors. This NSAID weakens their hypotensive effect.
Aspirin and other drugs containing acetylsalicylic acid. Such a combination is justified for the prevention of the occurrence of pathologies of the cardiovascular system during the treatment of Arcoxia. At the same time, the combination of drugs increases the risk of erosive lesions of the mucous membrane of the digestive tract.
Immunosuppressants (Cyclosporin and Tacrolimus). Simultaneous reception with Arcoxia has a nephrotoxic effect.
lithium preparations. This NSAID can increase its concentration in the blood.
Methotrexate. The question of the combination of this drug with Arcoxia is very relevant in rheumatology, since this cytostatic agent is the first-line drug for long-term therapy of rheumatoid arthritis. After clinical trials, doctors came to the conclusion that when using medications in recommended dosages, the risk of complications is minimal, however, it is possible to increase the side effects of Methotrexate.
Oral contraceptives. The risk of developing thromboembolism increases.
Corticosteroids. There were no complications associated with the combination with Arcoxia.
Rifampicin. Reduces the rate of NSAID metabolism in the liver.
Antacids. Do not affect the bioavailability and pharmacodynamics of the main drug.

When taking Arcoxia, the instructions for use describe in detail all the combination options with other drugs. However, if you have additional questions, it is better to consult with a specialist.

Arcoxia medicine: special instructions for use

The drug is sold in every pharmacy, you can buy it without a doctor's prescription. Store at room temperature, away from children. Shelf life - 3 years from the date of production. With prolonged use (more than 8 days), Arcoxia requires monitoring of blood pressure numbers and clinical indicators of liver function. If serious changes are detected, the drug should be discontinued. Also, the drug is not combined with other NSAIDs.

The drug Arcoxia slightly affects the ability of the egg to fertilize, which must be taken into account by women planning a pregnancy. The drug may cause drowsiness and dizziness. This needs to be taken into account by drivers and other patients whose work is related to the speed of reaction. The shell of the tablets contains a small amount of lactose, which can adversely affect the health of patients with lactase deficiency.

Arcoxia drug: analogues, use during pregnancy, lactation and at an early age, cost

There are no analogues of the drug with the same composition on the pharmaceutical market today. To some extent, other selective cyclooxygenase type 2 inhibitors can replace Arcoxia. However, their choice is very limited.

Relative analogues of this tool are:

Nimesulide (Nimulid, Nise, Nimesil), appoint 0.1-0.2 g twice a day.
Meloxicam (Amelotex, M-Kam, Movalis), take 7.5-15 mg once a day.

According to doctors and patients, this new NSAID very efficient. It quickly relieves pain and other symptoms of the inflammatory process. According to clinical trial data, Arcoxia is much less likely to cause side effects, regardless of the duration of treatment. It also features ease of use. The cost of a package of 28 tablets is: 30 mg - 692.00, 60 mg - 1016 rubles, 90 mg - 1362 rubles.

med88.ru

Arcoxia is a drug that belongs to the group of combining drugs.

The drug has the properties of an analgesic, antipyretic and anti-inflammatory agent. The drug is an improved second-generation inhibitor. A drug is prescribed to relieve acute symptoms of osteoarthritis, rheumatoid-type arthritis.

On this page you will find all the information about Arcoxia: complete instructions for use for this medicinal product, average prices in pharmacies, complete and incomplete analogues the drug, as well as reviews of people who have already used Arcoxia. Want to leave your opinion? Please write in the comments.

Clinical and pharmacological group

Terms of dispensing from pharmacies

Released without a doctor's prescription.

Prices

How much does Arcoxia cost? The average price in pharmacies is at the level of 420 rubles.

Release form and composition

Active ingredient medication is etoricoxib.

The drug is available in the form of tablets intended for oral administration. The quantitative content of the active ingredient Arcoxia: 60, 90, 120 mg each. Auxiliary elements are: lactose, cellulose, magnesium stearate, titanium dioxide, aluminum varnish based on dyes.

Pharmacological effect

Anti-inflammatory drug nonsteroidal group, which blocks the synthesis of prostaglandins and thereby has an anti-inflammatory, antipyretic and analgesic effect.

Indications for use

When is it advisable to take Arcoxia? Its use is quite wide, as it provides a quick analgesic effect, and also allows you to eliminate the inflammatory process.

Nevertheless, most often the drug is prescribed to patients suffering from osteoarthritis and. Indications for use are also pain caused by ankylosing spondylitis. In some cases, tablets are recommended for people who have recently undergone dental surgery.

Contraindications

Before using this drug, you should be examined by a doctor and find out if there are any contraindications for the use of Arcoxia. According to scientific research there are a number of contraindications:

tendency to gastrointestinal bleeding;
cerebrovascular bleeding;
individual intolerance to the components of the drug;
bronchial asthma;
polyposis of the nose or sinuses in the acute stage and frequent relapses;
intolerance;
ulcers, erosion and perforation of the gastrointestinal tract;
intestinal inflammation;
kidney disease in progress;
hyperkalemia;
blood diseases caused by clotting disorders (hemophilia);
liver failure in severe form;
hepatic diseases;
pregnancy and breastfeeding;
children under 16;
the period after the operation associated with coronary artery bypass grafting;
peripheral arterial disease;
blood pressure over 140/90 Hg;
cerebrovascular diseases;
lactase intolerance, lactase deficiency.

Use during pregnancy and lactation

The drug is contraindicated during pregnancy and lactation.

The use of the drug may adversely affect female fertility and is not recommended for women planning a pregnancy.

Instructions for use Arcoxia

The instructions for use indicate that Arcoxia tablets are taken orally at a dose of 60-120 mg 1 time / day.

In patients with hepatic insufficiency (5-9 points on the Child-Pugh scale), it is recommended not to exceed a daily dose of 60 mg.

Side effects

When using the drug Arcoxia, there is a possibility of developing unwanted side effects.

Sense organs: blurred vision.
Nervous system: against the background of taking Arcoxia, the development of dizziness, headache, and weakness is often observed. In rare cases, patients may complain of the development of anxiety, drowsiness, sleep disturbances and hypersensitivity.
Gastrointestinal tract: development of nausea, diarrhea, dyspepsia, flatulence. With prolonged use of the drug Arcoxia, the likelihood of side effects from the gastrointestinal tract increases.
Musculoskeletal system: In rare cases, Arcoxia can cause convulsions, arthralgia or myalgia.
Skin: in some cases, swelling of the face and itching may occur skin.
Cardiovascular system: palpitations, increased blood pressure. In rare cases, the use of Arcoxia can cause congestive heart failure, hot flashes, and cerebrovascular accidents.
Development of infections: in a number of cases, the development of gastroenteritis, as well as infections of the upper respiratory tract and genitourinary system, have been reported.

According to the results of laboratory studies, in rare cases there is a possibility of an increase in nitrogen in the urine and blood, as well as a decrease in hemoglobin levels.

Overdose

An overdose of Arcoxia has not been described. It is possible to increase the side effect of the drug, to eliminate which symptomatic treatment is carried out.

special instructions

It is necessary to prescribe with caution to patients taking other non-steroidal anti-inflammatory drugs, especially acetylsalicylic acid;
When prescribing the drug, perforation, ulceration or bleeding from the upper digestive tract is possible, up to death;
There should be careful monitoring of renal function in individuals prone to impaired renal function, since etoricoxib may reduce renal blood flow;
In the presence of pathology on the part of the heart or blood vessels, it is necessary to prescribe the drug in short courses and in the least effective dosage, since the use of etoricoxib may develop thrombotic complications;
With possible pathologies of the liver, it is necessary to control the level of transaminases in the blood;
Particular attention should be paid to the elderly, in the event of a dysfunction of any of the body systems, in the presence of dehydration in the patient;
Be wary when taking warfarin and other oral anticoagulants;
Etoricoxib is not recommended when planning a pregnancy;
Serious skin lesions appeared in isolated cases. Anaphylactic reactions and the development of Quincke's edema are possible, because of which attention should be paid to the presence allergic reactions in the patient's history for any medication. When the first skin manifestations appear, the medicine should be discontinued;
And the composition of Arcoxia includes lactose, as a result of which the drug is contraindicated in persons suffering from lactose intolerance;
When taking the drug, fluid retention in the body, the development of edema and arterial hypertension are possible. Therefore, when prescribing the drug for patients with a tendency to such phenomena, it is necessary to take precautions, pay special attention to the control of blood pressure, and in case of deterioration of the condition, take appropriate measures up to discontinuation of the drug and the appointment of alternative treatment.

drug interaction

Increase the risk of developing nephroticity reception with cyclosporine and tacrolimus.
Simultaneous reception with theotrexate increases its side effects.
Co-administration with rifampicin reduces the plasma AUC of etoricoxib by 65%.
When taken together, even at low doses, ASA leads to an increased risk of ulcerative lesions of the gastrointestinal tract.
This drug may slightly reduce the hypotensive effect of FGA inhibitors.
Taking simultaneously with antacids and ketoconazole, no significant effect on the formacokinetics of Arcoxia was noted.
Joint reception with oral contraceptives and a dose of Atkoksia 120 mg. - The development of thromboembolic complications increases.
Co-administration of the drug overdose(120 mg) with warfarin increases INR by 13%. This indicator should be monitored when changing the dose and at the beginning of therapy. If there is impaired renal function, then simultaneous administration with ACE inhibitors exacerbates renal functional insufficiency.

Arcoxia is a non-steroidal drug that reduces inflammation. It is a selective inhibitor of COX-2, at low doses it resists the appearance of prostaglandins. The drug has anti-inflammatory, analgesic and antipyretic effects. It is widely used for injuries, colds and other types of diseases. Selective inhibition of COX-2 when using the drug helps to reduce inflammatory processes, while not adversely affecting the blood cells and the mucosa of the gastrointestinal tract.

Composition and form of release

Arcoxia is only available as a turquoise coated tablet that looks like a small ball. Available in several varieties:

0.3 gr. They are available in blisters and boxes. One package contains one, two or four blisters, in which there are a different number of tablets. On average, their number varies from 2 to 14 pieces per pack.
0.6 gr. Their release is limited to seven pieces in one package of Arcoxia. In total, there are from one to four such packs in one box.
0.9 gr. Also, they have 7 pieces in one blister and the same number in a cardboard box.
0.12 gr. Seven tablets are produced, however, only one blister can be present in the box.

Composition of Arcoxia

As part of the drug, both the active substance and the auxiliary can be distinguished.

TO active substance includes etoricoxib in the amount of 0.3; 0.6; 0.9 or 0.12 gr. The exact content of this content depends on total dosage.
to excipients include: calcium hydrogen phosphate, microcrystalline cellulose, croscarmellose sodium, magnesium stearate.
Components of the shell itself: white Opadray II, carnauba wax.
The film on the shell consists of: lactose monohydrate, hypromellose, titanium dioxide, triacetin, aluminum lacquer, iron oxide yellow dye.

Indications for the use of Arcoxia

This is a remedy that relieves pain in the joints, as well as helping to reduce fever. Thus, the main indications for the use of the drug will be the following diseases:

Treatment of symptoms of gout, ankylosing spondylitis, rheumatism, accompanied by the presence of inflammatory processes and acute pain.
Arcoxia is given as an anesthetic after dental, gynecological, and all other abdominal surgeries.

Contraindications

Along with the main indications for admission, there are also contraindications. These include:

Hypersensitivity to individual parts of the drug.
"Bronchial" asthma, accompanied by lack of air and severe shortness of breath.
The presence of polyps inside the nose, as well as near the sinuses in the acute stage or with frequent manifestation.
Complete rejection of non-steroidal anti-inflammatory drugs.
The presence of ulcers, irritations and complications in the gastrointestinal tract.
Manifestation of gastric bleeding.
Cerebrovascular bleeding.
Numerous inflammatory processes in the intestines.
Hemophilic diseases.
Underdevelopment of the hepatic system.
Diseases associated with the liver.
Chronic kidney disease.
Hyperkalemia.
Postoperative period associated with shunting.
Peripheral diseases.
Elevated BP.
Pregnancy and lactation.
Childhood.
Allergic reactions to lactase.
Ischemic heart disease.

Side effects

Instructions for use warns of the following side effects that Arcoxia can cause:

epigastric pain;
impaired coordination of movements;
bowel problems;
dryness of the oral mucosa;
gastritis;
ulcer of the mucous membrane of the stomach or duodenum;
esophagitis;
ulcers of the oral mucosa;
ulcers of the gastrointestinal tract;
headache;
dizziness;
weakness;
lack of taste preferences;
drowsiness;
insomnia;
anxiety;
depression;
hallucinations;
confusion;
visual impairment;
purulent discharge from the eyes;
noise in ears;
anaphylactic shock, including the manifestation of hypotension;
rapid heartbeats;
hypertension;
early menopause;
violation of cerebral circulation;
atrial fibrillation;
hypertensive crisis;
dyspnea;
bleeding from the nose;
swelling of the face;
allergic reactions;
Stevens-Johnson syndrome;
Lyell's syndrome;
ENT diseases;
Muscle cramps;
arthralgia;
myalgia;
problems with urination;
loss of appetite;
weight gain;
leukopenia, thrombocytopenia;
flu-like syndrome;
pain in the chest.

The following precautions should be observed while taking Arcoxia:

Non-steroidal anti-inflammatory drugs, to which the agent belongs, can give unforeseen complications in the cardiovascular system, leading to myocardial infarction or to lethal outcome. To prevent such an effect, it is necessary to reduce the dosage of the application in a timely manner and stop treatment.
NSAIDs can cause complications in the gastrointestinal tract, which, in turn, can lead to serious problems with the mucosa - up to death. They can appear suddenly, regardless of the symptoms. Especially often after taking the remedy, elderly people are prone to such a problem.
While taking the drug Arcoxia, it is necessary to constantly monitor changes in readings in blood pressure. In addition, you should constantly monitor the work of the hepatic-renal system. In case of strong changes, it is necessary to stop the use of the drug in a timely manner.

Instructions for use

Etoricoxib is an oral COX-2 blocker. COX is responsible for the formation of prostaglandins. At the same time, one of its forms - COX 2 - is responsible for the neurotransmitters of pain, fever and inflammatory manifestations of the body. COX-2 is the main component during ovulation, insertion of implants, in monitoring the performance of the kidneys and the nervous system.

When Arcoxia is used orally, the absorption of substances by the gastrointestinal tract occurs in a short time. The active substance of Arcoxia is centralized in the liver, from where it is excreted almost completely by the kidneys. A small percentage of the substance is excreted in the urine in its original form.

Method and dosage

The drug should be taken orally, regardless of meals. The daily dose is built depending on the nature of the disease. The main condition is the ingestion of the smallest of all acceptable dosages for the least amount of time.

After swallowing the tablet, it must be washed down with a small amount of water for better walking and resorption by the gastrointestinal tract.

The dosage is prescribed by the attending physician, based on the specifics and course of a particular disease. So, you should take Arcoxia for various diseases in the following doses:

With osteoarthritis. Disease associated with the musculoskeletal system. The dosage should be 0.3 or 0.6 g per day.
Bechterew's disease and rheumatoid arthritis. These diseases are characterized by inflammation in the spine, as well as in its joints and soft tissues. Daily intake Arcoxia for such diseases is 0.9 g.
Acute gout. It is characterized by impaired uric acid metabolism, nodule formation, and lesions internal organs. For the treatment of this disease, it is necessary to take 0.12 gr. - with acute symptoms. In this case, the period of admission should not exceed a week.
In case of acute pain, it is necessary to take 0.6 g. disposable.
Postoperative period in dentistry. It should be taken 0.9 gr. drug at a time.
In case of liver failure, the dose of the drug should not exceed 0.6 g.

Arcoxia for children

Children under the age of 16 are prohibited from using the drug in any form. Upon reaching a predetermined age, the dosage for use is assigned to the minimum and in case of urgent need.

During pregnancy and lactation

Instructions for use prohibits taking the drug immediately after the onset of pregnancy. This is due to the fact that in the third trimester of pregnancy it can lead to a decrease in uterine contractions and early closure of the arterial duct. Etoricoxib, located in Arcoxia, contributes to the suppression of the female body to reproductive activity. Thus, when planning a pregnancy, it is also better to refuse to take the remedy.

During lactation it is forbidden to take Arcoxia. This can lead to problems in the development of the child, to whom all the substances that make up the medicine will come across through milk.

Interaction with other drugs

When taking the drug and other drugs at the same time, you need to know about the following rules:

With lithium. Arcoxia does not allow lithium to exit the body with urine, thereby contributing to its critical content in circulatory system.
with methotrexate. Possible manifestation of toxic effects on the body.
With contraceptives. There is a delay in their exit from the body, which can lead to such unpleasant consequences as the formation of blood clots in the veins.
With Digoxin. There is an increase in the toxic effect.
with rifampicin. The active substance mixed with this drug leads to a decrease in Etoricoxib in the circulatory system by more than half.
Antacids. Have no side effects on Arcoxia.

Domestic and foreign analogues

Arcoxia has only one analogue: Exinef. All other drugs have a composition similar to it:

Magnecard - tablets.
Dicloran Plus - gel.
Ibuprofen - suspension.
Celecoxib.
Celebrex.
Rancelex.
Denebola.
Dynastat.
Diclofenac.
Cefekon.
Apranax.
Brufen.
Veral.
Glucosamine sulfate.
Voltaren Emulgel.
DON.
Movasin.
Revma gel.
Tenoctyle.
Gypsy.

Along with these drugs, there are also others similar to those already listed.

Price in pharmacies

The price of Arcoxia in different pharmacies can vary significantly. This is due to the use of cheaper components and the pricing policy of the pharmacy chain.

Read the official information about the drug Arcoxia, the instructions for use of which include general information and a treatment regimen. The text is provided for informational purposes only and is not a substitute for medical advice.

NSAIDs. Etoricoxib is a selective inhibitor of COX-2, at therapeutic concentrations blocks the formation of prostaglandins and has anti-inflammatory, analgesic and antipyretic effects. Selective inhibition of COX-2 by etoricoxib is accompanied by a decrease in the severity of clinical symptoms associated with the inflammatory process, while there is no effect on platelet function and the mucosa of the gastrointestinal tract. Etoricoxib has a dose-dependent COX-2 inhibition effect with no effect on COX-1 at daily doses up to 150 mg. The drug does not affect the production of prostaglandins in the gastric mucosa and bleeding time. In the studies conducted, there was no decrease in the level of arachidonic acid and platelet aggregation caused by collagen.

Pharmacokinetics

Absorption

Rapidly absorbed when taken orally. Bioavailability when taken orally is about 100%. When using the drug in adults on an empty stomach at a dose of 120 mg C max - 3.6 mcg / ml, TC max in blood plasma - 1 hour after administration. The geometric mean AUC 0-24h was 37.8 µg × h/mL. The pharmacokinetics of etoricoxib within therapeutic doses is linear.

Eating does not significantly affect the severity and rate of absorption of etoricoxib at a dose of 120 mg. At the same time, there is a decrease in C max values by 36% and an increase in TC max by 2 hours.

Taking antacids does not affect the pharmacokinetics of the drug.

Distribution

Communication with plasma proteins when taking the drug exceeds 92%. The volume of distribution (Vd ss) at steady state is about 120 liters.

Etoricoxib has been shown to cross the placental and blood-brain barriers.

Metabolism

Intensively metabolized in the liver, with the participation of the cytochrome P450 isoenzyme (CYP) and the formation of 6-hydroxymethyl-etoricoxib. Less than 1% of the drug is excreted in the urine unchanged. Five metabolites of etoricoxib were found, the main ones being 6-hydroxymethyl-etoricoxib and its derivative, 6-carboxyacetyl-etoricoxib. The main metabolites do not affect COX-1 and are completely inactive or slightly active against COX-2.

breeding

With a single intravenous injection of a labeled radioactive drug containing etoricoxib at a dose of 25 mg to healthy volunteers, it was demonstrated that 70% of the drug is excreted through the kidneys, 20% through the intestines, mainly in the form of metabolites. Less than 2% is found unchanged. Excretion of etoricoxib occurs mainly by metabolism through the kidneys. The equilibrium concentration of the drug is reached at daily intake 120 mg of the drug after 7 days, with a cumulation coefficient of about 2, which corresponds to a half-life of about 22 hours. Plasma clearance is approximately 50 ml / min. There are no pharmacokinetic differences between men and women. Pharmacokinetics in the elderly (65 years and older) is comparable to that in young people. There is no need to adjust the dose of the drug in the elderly. Racial differences do not affect the pharmacokinetic parameters of etoricoxib.

Use in children

The pharmacokinetic parameters of etoricoxib have not been studied in children under 12 years of age. In comparative pharmacokinetic studies, comparable data were obtained with the use of etoricoxib in the group of adolescents (from 12 to 17 years old) weighing 40-60 kg at a dose of 60 mg / day, in the same age group and weighing more than 60 kg - 90 mg / day, as well as the same in adults when taking 90 mg / day.

Release form

Blue-green, biconvex, apple-shaped film-coated tablets, debossed "ACX 30" on one side and debossed "101" on the other.

	1 tab.
etoricoxib	30 mg

Excipients: calcium hydrogen phosphate 30 mg, microcrystalline cellulose 37 mg, croscarmellose sodium 2 mg, magnesium stearate 1 mg.

Shell composition: Opadry II Blue-Green 39K11526, carnauba wax.
The composition of the film shell: lactose monohydrate, hypromellose, titanium dioxide, triacetin, aluminum varnish based on indigo carmine dye (E132), iron oxide yellow dye (E172).

2 pcs. - blisters (1) - packs of cardboard.
2 pcs. - blisters (2) - packs of cardboard.
4 things. - blisters (1) - packs of cardboard.
4 things. - blisters (2) - packs of cardboard.
7 pcs. - blisters (1) - packs of cardboard.
7 pcs. - blisters (2) - packs of cardboard.
14 pcs. - blisters (1) - packs of cardboard.
14 pcs. - blisters (2) - packs of cardboard.
7 pcs. - blisters (4) - packs of cardboard.
14 pcs. - blisters (4) - packs of cardboard.
4 things. - blisters (4) - packs of cardboard.
2 pcs. - blisters (4) - packs of cardboard.

Dosage

Inside, regardless of the meal, drinking a small amount of water.

Rheumatoid arthritis and ankylosing spondylitis:

Acute gouty arthritis:

The recommended acute dose is 120 mg once daily. The duration of use of the drug at a dose of 120 mg is no more than 8 days. The lowest effective dose should be used for the shortest possible course.

The average therapeutic dose for pain is 60 mg once a day.

Overdose

Overdose of Arcoxia has not been reported in clinical trials. In clinical trials, Arcoxia at a single dose of up to 500 mg or multiple doses of up to 150 mg/day for 21 days did not cause significant toxic effects; In case of an overdose of the drug, undesirable effects from the gastrointestinal tract, cardiovascular system and kidneys may occur. In case of overdose, symptomatic therapy is carried out.

Etoricoxib is not excreted by hemodialysis, elimination of the drug by peritoneal dialysis has not been studied.

Interaction

Pharmacodynamic interaction

Oral anticoagulants (warfarin): In patients receiving warfarin, Arcoxia 120 mg daily was associated with an increase of approximately 13% in the International Normalized Ratio (MHO) of prothrombin time. In patients receiving warfarin or similar medicinal products, MHO values should be monitored during the initiation or change of treatment with Arcoxia, especially in the first few days.

Diuretics, angiotensin-converting enzyme (ACE) inhibitors: There are reports that non-selective NSAIDs and selective COX-2 inhibitors may reduce the hypotensive effect of ACE inhibitors. This interaction should be taken into account when treating patients taking Arcoxia concomitantly with ACE inhibitors. In patients with impaired renal function (for example, with dehydration or in old age), such a combination may aggravate renal failure.

Acetylsalicylic acid: Arcoxia can be used concomitantly with low dose acetylsalicylic acid for the prevention of cardiovascular disease. However, co-administration of low doses of acetylsalicylic acid and Arcoxia may lead to an increased incidence of gastrointestinal ulceration and other complications compared with Arcoxia alone. At steady state, etoricoxib at a dose of 120 mg once a day does not affect the antiplatelet activity of acetylsalicylic acid at low doses (81 mg per day). The drug does not replace the preventive action of acetylsalicylic acid in cardiovascular diseases.

Cyclosporine and tacrolimus: increase the risk of developing nephrotoxicity when taking the drug.

Pharmacokinetic interaction

Lithium: There is evidence that non-selective NSAIDs and selective COX-2 inhibitors can increase plasma lithium concentrations. This interaction should be taken into account when treating patients taking Arcoxia concomitantly with lithium.

Methotrexate: Two studies examined the effects of Arcoxia 60, 90, and 120 mg once daily for seven days in patients treated with once weekly methotrexate 7.5 to 20 mg for rheumatoid arthritis. 60 and 90 mg had no effect on plasma concentration (according to AUC) and renal clearance of methotrexate. In one study, Arcoxia at a dose of 120 mg had no effect on the plasma concentration (AUC) and renal clearance of methotrexate. In another study, Arcoxia at a dose of 120 mg increased the plasma concentration of methotrexate by 28% (according to AUC) and reduced the renal clearance of methotrexate by 13%. With the simultaneous appointment of Arcoxia in doses above 90 mg per day and methotrexate, it is necessary to monitor the possible occurrence of toxic effects of methotrexate.

Oral contraceptives: Taking Arcoxia 120 mg with oral contraceptives containing ethinyl estradiol (EE) 35 mcg and norethindrone 0.5 to 1 mg for 21 days, simultaneously or 12 hours apart, increases steady-state AUC0-24hr for EE by 50 -60%. However, the concentration of norethisterone usually does not increase to a clinically significant extent. This increase in EE concentration should be taken into account when choosing the appropriate oral contraceptive for concomitant use with Arcoxia. This fact may lead to an increase in the frequency of thromboembolism due to an increase in EE exposure. No significant pharmacokinetic interaction with glucocorticosteroids was found.

Digoxin: Etoricoxib does not affect the steady-state AUC 0-24h or the elimination of digoxin. At the same time, etoricoxib increases C max (by an average of 33%), which may be important in the development of an overdose of digoxin.

Rifampicin: Co-administration of Arcoxia and rifampicin, a potent inducer of hepatic metabolism, results in a 65% reduction in plasma etoricoxib AUC. This interaction should be taken into account when prescribing
Arcoxia with rifampicin.

Antacids and ketoconazole (a potent inhibitor of CYP3A4) do not have a clinically significant effect on the pharmacokinetics of Arcoxia.

Side effects

Very often ≥10%, often -1-10%; infrequently - 0.1-1%; rarely - 0.01-0.1%; very rarely - less than 0.01%, including isolated cases.

From the digestive system: often - epigastric pain, nausea, diarrhea, dyspepsia, flatulence; infrequently - bloating, belching, increased peristalsis, constipation, dryness of the oral mucosa, gastritis, ulcer of the mucous membrane of the stomach or duodenum, irritable bowel syndrome, esophagitis, ulcers of the oral mucosa, vomiting; very rarely - gastrointestinal ulcers (with bleeding or perforation).

From the hepatobiliary system: very rarely - hepatitis.

From the nervous system: often - headache, dizziness, weakness; infrequently - a violation of taste, drowsiness, sleep disturbances, a violation of sensitivity, incl. paresthesia / hyperesthesia, anxiety, depression, concentration disorders, very rarely hallucinations, confusion.

From the senses: infrequently - blurred vision, conjunctivitis, tinnitus, vertigo.

From the urinary system: infrequently - proteinuria; very rarely - renal failure, usually reversible when the drug is discontinued.

Allergic reactions: very rarely - anaphylactic / anaphylactoid reactions, including a pronounced decrease in blood pressure and shock;

From the side of the cardiovascular system: often - palpitations, increased blood pressure; infrequently - hot flashes, cerebrovascular accident, atrial fibrillation, congestive heart failure, nonspecific ECG changes; myocardial infarction, very rarely - hypertensive crisis.

From the respiratory system: infrequently - cough, shortness of breath, nosebleeds; very rarely - bronchospasm.

From the side of the skin: often - ecchymosis; infrequently - swelling of the face; skin itching, rash; very rarely - urticaria, Stevens-Johnson syndrome, Lyell's syndrome.

Infections: infrequently - gastroenteritis, infections of the upper respiratory tract, urinary tract.

From the musculoskeletal system: infrequently - muscle cramps, arthralgia, myalgia.

Metabolic disorders: often - edema, fluid retention; infrequently - changes in appetite, weight gain.

Others: often - flu-like syndrome; infrequently - pain in the chest.

The results of laboratory studies: often - an increase in "liver" transaminases; infrequently - an increase in nitrogen in the blood and urine, an increase in the activity of creatine phosphokinase, a decrease in hematocrit, a decrease in hemoglobin, hyperkalemia, leukopenia, thrombocytopenia, an increase in serum creatinine, an increase in uric acid; rarely, an increase in sodium in the blood serum.

Indications

Symptomatic therapy of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, pain and inflammatory symptoms associated with acute gouty arthritis.

Contraindications

complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose or paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (including history);
erosive and ulcerative changes in the gastric mucosa or duodenum, active gastrointestinal bleeding; cerebrovascular or other bleeding;
inflammatory bowel disease (Crohn's disease, ulcerative colitis) in the acute phase;
hemophilia and other bleeding disorders;
severe heart failure (NYHA II-IV);
severe liver failure (more than 9 points on the Child-Pugh scale) or active liver disease;
severe renal failure (creatinine clearance less than 30 ml / min), progressive kidney disease, confirmed hyperkalemia; - the period after coronary artery bypass grafting; peripheral arterial disease, cerebrovascular disease, clinically significant coronary heart disease;
persistent values of blood pressure exceeding 140/90 mm Hg. Art. with uncontrolled arterial hypertension;
pregnancy, breastfeeding period;
children's age up to 16 years;
hypersensitivity to any component of the drug.

With caution: anamnestic data on the development of ulcerative lesions of the gastrointestinal tract, the presence of infection Helicobacter pylori, older age, long-term use of NSAIDs, frequent alcohol use, severe somatic diseases, dyslipidemia / hyperlipidemia, diabetes mellitus, arterial hypertension, edema and fluid retention, smoking, creatinine clearance less than 60 ml / min, concomitant therapy with the following drugs:

anticoagulants (eg warfarin);
antiplatelet agents (eg. acetylsalicylic acid, clopidogrel);
oral glucocorticosteroids (eg, prednisolone);
selective serotonin reuptake inhibitors (eg, citalopram, fluoxetine, paroxetine, sertraline).

In patients with hepatic insufficiency (5-9 points on the Child-Pugh scale), it is recommended not to exceed a daily dose of 60 mg.

Application features

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

Application for violations of liver function

In patients with mild hepatic impairment (5-6 points on the Child-Pugh scale), a single dose of etoricoxib at a dose of 60 mg / day was accompanied by a 16% increase in AUC compared with healthy individuals.

In patients with moderate hepatic impairment (7-9 points on the Child-Pugh scale), who took the drug at a dose of 60 mg every other day, the AUC value was the same as in healthy individuals who took the drug daily at the same dose.

Data from clinical and pharmacokinetic studies in patients with severe hepatic impairment (more than 9 points on the Child-Pugh scale) are not available.

Application for violations of kidney function

Pharmacokinetic parameters of a single dose of etoricoxib at a dose of 120 mg in patients with moderate and severe kidney damage and with terminal stage chronic renal failure (CRF) on hemodialysis did not differ significantly from those in healthy individuals. Hemodialysis had little effect on excretion (dialysis clearance - about 50 ml/min).

Use in children

Contraindicated in children under 16 years of age.

Use in elderly patients

Pharmacokinetics in the elderly (65 years and older) is comparable to that in young people. There is no need to adjust the dose of the drug in the elderly.

special instructions

You should also regularly monitor liver and kidney function.

In the case of an increase in the level of "liver" transaminases by 3 times or more, relatively upper bound normal, the drug should be discontinued.

The use of the drug may adversely affect female fertility and is not recommended for women planning a pregnancy.

The shell of the drug Arcoxia contains lactose in a small amount, which should be taken into account when prescribing the drug to patients with lactase deficiency. During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions. Patients who have experienced episodes of dizziness, drowsiness or weakness should refrain from activities that require concentration.

This drug belongs to modern drug products, developed taking into account the shortcomings of the previous generation. Any medication not only improves the well-being of a person in a certain area of the body, but also negatively affects the vital important organs human, so the drug developers have made every effort to reduce the number of side effects.

The main active component of the drug is etoricoxib, which is part of the group of non-steroidal anti-inflammatory components. Due to the fact that Arcoxia acts purposefully on the area of inflammation, the total number of adverse reactions decreases, and the main manifestations of the inflammatory process (pain, swelling, fever) disappear very quickly.

IMPORTANT!!! Among the drugs developed for the treatment of pathologies of the musculoskeletal system, this medical preparation considered the safest for the health of the patient.

So, Arcoxia has the following effect on the affected area of the musculoskeletal system:

anti-inflammatory;
antipyretic;
anesthetic.

Forms of release, composition and mechanism of work

The pharmaceutical product is sold in the form of tablets of 60 mg, 90 mg and 0.12 g. It is worth noting that other types, whether it be ointment, suppositories or injections in ampoules, are absent from the drug. The active ingredient in Arcoxia is etoricoxib. therapeutic effect which lies in the ability to suppress the activity of the COX-2 enzyme.

As a result, the metabolism of omega-6-unsaturated fatty acids is disrupted and the level of prostaglandins in the focus of inflammation decreases. Thus, the medicine stops the pain impulse, eliminates the stiffness of the joints, which usually worries people in morning time, and returns the person to the previous physical activity.

The best chondroprotectors for arthrosis of the knee joint and others: classification, prices

A healthy knee joint is a well-functioning biological machine in which mechanical movements are carried out due to a clear balancing of processes of various nature. One of the leading roles belongs to biochemical processes, in particular, the processes of destruction and synthesis of articular cartilage proceed at the same speed.

If, as a result of some reasons, this balance is disturbed, the process of destruction can become the main one. Dystrophic and degenerative processes are observed in cartilage tissues, which is accompanied by severe pain, impaired motor function, and in the future can lead to its destruction and joint deformity.

This disease is called arthrosis. To treat this condition, substances are needed that can protect and restore destroyed articular cartilage.

Such substances exist and are called chondroprotectors. According to statistics, arthrosis most often affects the knee joint.

Classification of fondroprotectors

The principles underlying the classification of chondroprotectors may be different. The most commonly used division is based on which active substances are used in a given preparation.

You can select drugs based on:

Glucosamine is a substance that directly contributes to the synthesis of cartilage and neutralizes almost all substances that harm its tissues.
Chondroitin sulfate - macromolecular compound contained in the connective tissue of animals. Basically, it is found in cartilage either in a free form, or is part of the intra-articular fluid. Its function is nutrition and cushioning in the joint. Chondroitin affects the exchange of phosphorus and calcium in cartilage, it stimulates collagen synthesis, providing tissue elasticity, and also inactivates enzymes that destroy cartilage.

Hyaluronic acid is a polysaccharide contained in the intercellular space, some tissues and body fluids, in particular, intraarticular fluid. One of its most important features is the ability to bind and hold a large number of water molecules. To fulfill its depreciation function synovial fluid should have a certain viscosity value, which ensures hyaluronic acid, and also it reduces the sensitivity of pain receptors inside the joint.
Combined, containing more than one active substance. They have a much more pronounced therapeutic effect than monopreparations.

Another principle of classification of chondroprotectors is based on the concept of generations of chondroprotectors. Usually there are three generations:

The first generation includes drugs made from animals and raw materials.
By the second generation - isolated in pure form glucosamine, chondroitin sulfate and hyaluronic acid.
The third - chondroprotectors of a new generation, include drugs that have a combination of active substances. This includes not only glucosamine, chondroitin and hyaluronic acid, but vitamins, fatty acids and various substances, which provide additional effectiveness of chondroprotectors in the treatment of knee arthrosis.

Features of treatment with chondroprotectors

At present, the most widespread medical practice received second-generation chondroprotectors for joints. Their application has some peculiarities.

Treatment of osteoarthritis of the knee joint (gonarthrosis) with chondroprotectors has maximum effectiveness at stages 1 or 2 of arthrosis, but if the joint is already deformed or the cartilage is completely destroyed, chondroprotectors will not help.

With osteoarthritis of the knee, a person consults a doctor in a state where the knee joint hurts a lot when walking and at rest, it can swell. At this time, the main task is to relieve the patient of pain as soon as possible, providing him with an acceptable quality of life.

In such a situation, chondroprotectors will not help, because for all their remarkable advantages, the speed of exposure is not their strong point. In the acute phase of arthrosis, non-steroidal anti-inflammatory drugs are often prescribed:

Diclofenac;
Piroxicam;
Indomethacin;
Ketoprofen;

Butadion;
Nimulid;
Celebrex;
Meloxicam.

How can cervical osteochondrosis be cured

Joint pain - treatment with folk remedies. Diseases of the joints, ligaments and muscles general concept- rheumatic diseases. This disease can manifest itself in various ways.

The most common: arthrosis (changes in joints), arthritis (inflammation of the joints), rheumatism, gout, muscular rheumatism. Osteoarthritis is most often the wear and tear of the joints caused by age, in which the joints swell slightly and ache when exerted.

Additional treatment assistance:

Relieves pain and swelling in the joints with arthritis and arthrosis
Restores joints and tissues, effective for osteochondrosis

To learn more…

Chlamydial arthritis is one of the most common types of post-infectious arthropathies. This disease is associated with a previous chlamydial urethrogenital infection and ranks first (seventy percent) in frequency of occurrence among reactive arthropathies (ReA).

For a long time, it was believed that chlamydial infection only triggers an abnormal immune response and provokes an inflammatory process. However, in Lately microscopic examination of the articular effusion made it possible to isolate the pathogen - chlamydia.

Etiology of the disease

Purchasing funds

Arcoxia is available in the form of tablets with different dosages of the active substance. This distinction allows you to unify the use of the drug: depending on the severity of the symptoms, the dosage of the remedy is also selected.

As studies of a pharmaceutical product show, its optimal use looks like this:

tablets containing 60 mg of the active substance should be used to relieve pain in patients diagnosed with osteoarthritis. Such pills are green in color;
rheumatoid arthritis and ankylosing spondylitis not only provoke strong pain symptoms, but also significantly limit the mobility of the joints. Arcoxia with 90 mg of etoricoxib in one tablet, which is distinguished by white color, effectively stops inflammation, reduces pain and returns the joy of movement;
gouty arthritis, manifesting itself as acute sudden attacks, requires the appointment of a maximum dosage of etoricoxib in an amount of 120 mg per pill. As studies show, improvement is observed already four hours after taking a tablet, painted in a light green tint.

IMPORTANT!!! Even if there is established diagnosis it is strictly forbidden to prescribe this drug for yourself: the decision to take Arcoxia and its dosage is made only by the attending physician.

When co-administered with ACE inhibitors, it is possible to weaken the hypotensive effect of ACE inhibitors. With impaired renal function, this combination may lead to further aggravation functional insufficiency kidneys.

READ ALSO: Gymnastics for the knees with arthrosis video

With the simultaneous use of Arcoxia with warfarin or similar drugs at the beginning of therapy and with each change in the dosing regimen of the drug, prothrombin time and INR (international normalized ratio) should be monitored.

Arcoxia is a modern remedy that treats inflammatory diseases of the musculoskeletal system. The drug contains etoricoxib, which is the active ingredient.

This medicine belongs to the group of non-steroidal anti-inflammatory drugs. But, if you compare it with analogues, it has many advantages, and therefore is rapidly gaining popularity.

Also in the composition of the drug there are other auxiliary components.

The active substance reduces swelling, fever, pain. Its action is directed directly to the focus of inflammation. The drug has a narrow focus, so the list of side effects is reduced as much as possible, which cannot be said about the drugs in this group.

On sale you can find a tablet form of the drug, which has different dosage.

It is not recommended to independently engage in dose selection, as this should be done by a specialist.

Not always a specific drug is suitable for a person. But this does not mean that treatment should be stopped. In this case, the doctor prescribes an analogue. What remedy is suitable instead of the drug Arcoxia? There are many analogues of it, so the doctor will be able to choose suitable drug.

If the purpose of using Arcoxia was pain relief, but this remedy is not suitable for a person, then it is worth replacing it with other non-steroidal anti-inflammatory drugs. For this purpose, Ibuprofen, Diclofenac or Nurofen are suitable. There are many other similar drugs.

If a person suffers from osteoporosis or other diseases of the musculoskeletal system, then the doctor will give preference to other drugs if Arcoxia is not suitable. Analogues of the remedy are such drugs as Alendros, Ostalon and others.

This medicine is for oral use. Its intake does not depend on food intake. Given the nature of the pathology, the doctor is determined with daily dosage drug. After a person swallows a pill, it should be washed down with water, which will help to dissolve faster in the stomach, which will speed up the onset of the drug.

It must be remembered that the doctor determines the dosage, taking into account the specifics of the disease.

The instructions for use contain the following information regarding the administration of the drug:

If a person has osteoarthritis, then he needs to use 0.03-0.06 g of medication per day.
If the patient has experienced rheumatoid arthritis or Bechterew's disease, then he is prescribed 0.09 g of the drug. It should be noted that such diseases are characterized by an inflammatory process in the spinal zone and joints.
Arcoxia is also prescribed for gout. With such a disease, the exchange of uric acid is disturbed in a person, various organ lesions appear. During medical therapy, the doctor prescribes 0.12 g of this medicine if the symptoms are in the acute stage. But it is worth remembering that such treatment should not last longer than a week.
If a person has acute pain, then he needs to use 0.06 g of the medicine at a time. The same dose is prescribed for people who have liver failure.
This remedy is prescribed after an operation related to dentistry. In this case, a single dose with a dosage of 0.09 g is necessary.

When administered orally, the absorption of the drug occurs in the organs of the digestive tract, while the bioavailability of the drug (that is, the ability of the drug to be absorbed) reaches 100%. Pre-meal has little effect on the absorption of Arcoxia.

The use of Arcoxia requires caution when simultaneous use with the following drugs (does not require discontinuation of these drugs):

indirect anticoagulants(Warfarin) - frequent monitoring of INR and prothrombin index is required;
ACE inhibitors - it is possible to reduce the antihypertensive effect of the latter;
other NSAIDs - possible aggravation of side effects on the gastrointestinal tract;
immunosuppressants (Uiklosporin, Tacrolimus) - can enhance the nephrotoxic effect of the drug.

Due to the presence of data on the passage of etoricoxib through the placenta, the use of Arcoxia is contraindicated during pregnancy and during lactation. Clinical studies do not provide data on the use of the drug in children under 12 years of age.

Arcoxia is available in tablets, 7 pieces in a blister of 30, 60, 90 and 120 mg of the active ingredient, the average price in the Russian Federation is 530 rubles per 60 mg / 7 tablets.

The medicine should be stored in a place protected from sunlight, at room temperature, away from children.

When buying, you must present a prescription from your doctor for this drug.

Arcoxia is a non-steroidal anti-inflammatory drug (NSAID). It has such pronounced effects as: analgesic, anti-inflammatory, antipyretic.

Reviews of patientsReviews of doctorsConclusion

Arcoxia is available in tablet form. Prescribe a drug for the treatment of diseases such as:

ankylosing spondylitis (Bekhterev's disease);
rheumatoid arthritis;
osteoarthritis;
acute pain after dental surgery;
arthritis in gout.

Consider the reviews of patients taking this drug, as well as specialists.

Reviews of patients about the drug Arcoxia

“My doctor miscalculated when he prescribed me Arcoxia to reduce joint pain, I have arthrosis. The drug appears to increase blood pressure. So my acquaintance with Arcoxia ended in a hypertensive crisis. I switched back to the proven diclofenacs. With the stomach, of course, trouble, but the pressure does not jump.

“I had a very bad pain in my hip joints, I struggled with this problem for 6 months. All to no avail, only the pain intensified.

I was very surprised when a young doctor prescribed me Arcoxia, which I had never even heard of. Just a few days of taking this drug began to make my life much easier.

I can’t say that the pains disappeared instantly, but they all gradually disappeared. I didn't notice any side effects."

Ksenia

“I was treated with this drug for about 10 days (although the course was prescribed for 1 month). Of course, the joint pains are gone, but the side effects exceeded all expectations. Terrible edema appeared, and not only on the legs, but also on the arms and face. Blood pressure also jumped 160/100 mm Hg. (although my usual pressure was 100/70 mmHg). With all this, the appetite disappeared, the liver increased.

To put it mildly, the side effects were much more than the therapeutic effect. The dose was quite small, only 60 mg per day. In general, immediately stopped treatment. I have not taken the drug for 5 days, but the swelling still persists, and the pressure is still high - 130/80 mm Hg. (sometimes 140/80 mm Hg).

Yes, another unpleasant moment is the high cost of the drug.

“I was prescribed Arcoxia by a doctor medical sciences. Since I have Bechterew's disease, I need to take the drug constantly. I started with a dose of 90 mg per day, was treated for more than a year. Now the doctor has allowed to reduce the dose to 60 mg per day. Fortunately, this medicine helps me very well. I somehow don’t notice anything from the side effects, though my wife says that my face is a little swollen. ”Vladimir

READ ALSO: Painkillers for arthrosis - Orthopedist.info

In order to deal with the many drugs that are offered for the treatment of arthrosis of various joints, you need to understand what happens in the body with this disease. Wherever osteoarthritis manifests itself (may be in the knee, ankle, hip or hand joints), the disease will occur one at a time. general principle.

The active ingredient in Arcoxia is etoricoxib. In addition to it, the medication contains auxiliary components. The tablets are coated and available in 30, 60, 90 and 120 mg etoricoxib. This allows you to choose the option of a remedy for relieving symptoms of different intensity.

Are there injections and ointment with Arcoxia? No, this drug has only one form of release - tablets. Also, the medicinal product does not contain analogues in which active substance was etoricoxib.

How does Arcoxia work?

The drug is included by pharmacologists in the group of highly selective inhibitors of cyclooxygenase-2. Arcoxia inhibits the activity of this enzyme, thereby leading to a decrease in the level of prostaglandins in both inflammatory tissues and nerve fibers. As a result, the drug relieves pain and fever, reduces the intensity of inflammation.

Many people who first encountered the problem joint pain, are helpless in front of her, because they do not know what to do and how to treat the disease.

However, today there are very effective anti-inflammatory drugs for arthrosis and arthritis, which can affect the underlying cause of the pathology and the condition of the joints in different ways.

I would like to immediately warn those patients who are in no hurry to seek help from a doctor, but prefer to diagnose and treat the disease on their own. Any self-medication can bring irreparable harm to the entire body.

You need to take only those medicines that the doctor has prescribed.

Nonsteroidal drugs for joint diseases

Non-steroidal anti-inflammatory drugs (NSAIDs, NSAIDs) are the most effective in arthrosis and arthritis of any origin. The main task of these drugs is to influence the focus of inflammation in the joints and eliminate pain.

Unlike corticosteroids ( hormonal drugs), NSAIDs do not contain hormones, which reduces the number of side effects on the body.

What are the most effective anti-inflammatory drugs for joint diseases? What are their benefits, and is there any harm from them? How do these drugs affect the disease and condition of the joints, as well as the body as a whole? We will talk about this in this article.

How to use the drug

Arcoxia is designed to help eliminate inflammatory processes in the patient's joint and bone tissues, expressed in severe pain and fever in the area of the lesion. As the instructions for the use of the drug indicate, the medication quickly and effectively stops the manifestations of the inflammatory process, while practically not affecting the mucous membrane of the gastrointestinal tract.

Therefore, Arcoxia is prescribed for the following diseases and pathologies:

rheumatoid arthritis: a systemic ailment, the exact causes of which have not been fully identified. It manifests itself in the defeat of the connective tissue of small joints (hands, feet), is characterized by a rapid transition to a chronic form and frequent relapses. The main causes of the disease are injuries left without medical attention, acute respiratory viral diseases and infectious lesions internal systems;
polyarthritis: an acute inflammatory process that usually affects several joints at the same time. It is more often caused by an infectious inflammatory process, metabolic disorders in the body, trauma or autoallergy (intolerance of one's own tissues);

The choice of the optimal dosage, the regimen of administration and the duration of treatment is determined only by the specialist who prescribed the medicine to the patient. It is strictly forbidden to make any adjustments to this scheme on your own, therefore, if undesirable consequences of taking the medicine appear, stop drinking and immediately consult a doctor.

If the drug is not suitable for a person, the doctor will replace it with an analogue or select other medicines.

In the event that the treatment is satisfactory, Arcoxia is taken as follows: the tablets are washed down with plenty of water, without chewing or crushing. It is allowed to break the pill in half, if for some reason the patient is not able to swallow it whole.

IMPORTANT!!! The medicine is taken regardless of the meal, but studies show that the pill drunk on an empty stomach acts much faster.

Reception is carried out once a day, preferably at the same time (permissible backlash - no more than one hour). The duration of therapy should not be more than eight days, since the drug has a strong effect on the body.

The recommended treatment regimen depends on the disease diagnosed in the patient. So, with osteoarthritis, you need to take one tablet with a minimum dosage (60 mg) or half of it - it depends on the severity of the symptoms.

Rheumatoid arthritis and spondylitis imply a dosage of 90 mg, one pill per 24 hours is also enough. The highest dosage of the drug (120 mg) is recommended for acute gouty arthritis, but regardless of the strength of the pain, taking more than one tablet per day is contraindicated.

If the final diagnosis has not yet been established, and the patient complains of acute pain in the joint, it is allowed to prescribe Arcoxia in an average or maximum dosage to eliminate unpleasant phenomena. Once the disease is identified, the doctor will be able to adjust the treatment or leave it unchanged.

To prevent the development of inflammation in the presence of chronic diseases of the musculoskeletal system, a course of treatment with a minimum dosage is usually prescribed. Interruptions in treatment and the frequency of preventive measures are determined by specialists on an individual basis.

If treatment is prescribed to a person suffering from pathologies of the cardiovascular system, the duration of the drug should be as short as possible in order to reduce the risk of possible complications.

The treatment regimen is the same for representatives of all age categories; elderly patients do not need to reduce it.

Arcoxia tablets are intended for oral use with or without food. The drug is washed down with a small amount of water.

osteoarthritis: 60 mg once a day (maximum daily dose is 60 mg);
rheumatoid arthritis and ankylosing spondylitis: 90 mg once a day (the maximum daily dose is 90 mg);
acute gouty arthritis: 120 mg once a day (maximum daily dose is 120 mg);
with pain syndrome, the average therapeutic dose is 60 mg once.

When using Arcoxia at a dose of 120 mg, the duration of treatment should not exceed 8 days. It is recommended to use the drug in the minimum effective dose for the shortest possible course.

To eliminate acute pain after dental surgery, etoricoxib 90 mg is prescribed once a day for no more than 8 days (the maximum daily dose is 90 mg). In hepatic insufficiency, the maximum daily dose should not exceed 60 mg.

The drug is taken once a day.

Having studied the information about the drug and having consulted a doctor, you can safely proceed to treatment. The therapeutic course depends on the diagnosis and the individual characteristics of the human body.