Dioxidine one percent. Solution in ampoules and dioxidine ointment for a child or adult - release form, composition, side effects and price

Dioxidine is an antibacterial drug from the group of quinoxaldine derivatives, which has a bactericidal, antibacterial effect on various pathogens: Pseudomonas aeruginosa, staphylococci, pathogenic anaerobes and other strains of bacteria resistant to other antibiotics.

Release form and composition

They produce Dioxidine solution for local and intracavitary use 1%. 1 ml of the solution contains the active ingredient - hydroxymethylquinoxaline dioxide - in the amount of 10 mg. In ampoules of 10 ml. The excipient is water for injection.

Indications for use

According to the instructions, Dioxidin is indicated for use in bacterial infections that are sensitive to active ingredient drug.

External use of Dioxidin is advisable in the following cases:

• Deep or superficial wounds on the body;
• Trophic ulcers and long-term non-healing wounds;
• infected burns;
• Phlegmon of soft tissues;
• Purulent wounds in osteomyelitis.

Intracavitary administration of Dioxidin is indicated in the following cases:

• Purulent processes in the abdominal or chest cavity;
• Bile duct wounds and urinary tract;
• Pleural empyema;
• Peritonitis;
• Abscesses;
• Purulent pleurisy;
• Wounds and phlegmon with the presence of deep purulent cavities (phlegmon of the pelvic tissue, soft tissue abscesses, purulent mastitis, postoperative wounds biliary and urinary tract).

Contraindications

According to the instructions, Dioxidin should not be used in the following cases:

• During pregnancy and breastfeeding;
• adrenal insufficiency;
• Hypersensitivity to the active component of the drug;
• Children's age (the efficacy and safety of the drug in pediatric practice).

Dioxidine is prescribed with caution when kidney failure.

Method of application and dosage

The use of Dioxidin is carried out in a hospital. Apply the solution intracavitary or externally. It is forbidden to use Dioxidine 1% solution for intravenous administration due to its instability when stored at low temperatures.

Outwardly, a 0.1-1% solution of Dioxidine is used. To obtain a solution of 0.1-0.5%, the ampoule of the drug should be diluted to the desired concentration NaCl solution isotonic or water for injection.

For superficial infections festering wounds ah shows the application of napkins moistened with a 0.5-1% Dioxidine solution to the affected areas of the body. After processing deep wounds they are swabbed with swabs soaked in a 1% Dioxidine solution. In the presence of a drainage tube, a 0.5% solution is injected into the cavity in an amount of 20-100 ml.

With osteomyelitis, accompanied by the presence of deep purulent wounds on the feet and palms, baths are made with a 0.5-1% Dioxidin solution or the affected areas are treated with a solution for 15-20 minutes. After treatment, apply a bandage with a 1% solution of the drug.

In order to prevent infection after surgical interventions, the use of a Dioxidine solution of 0.5-1% is indicated. With good tolerability of the drug, treatment can be continued for 6-8 weeks.

With the intracavitary use of Dioxidin in purulent cavity injected 10-50 ml of a 1% solution per day (depending on the size of the lesion). The introduction into the cavity is carried out through a catheter, syringe or drainage tube.

The maximum dose for intracavitary use of the drug should not exceed 70 ml of a 1% solution per day.

As a rule, the drug is administered once a day, if necessary, division is allowed. daily dose for two doses. If Dioxidin is well tolerated, it can be used for three or more weeks. Repeated courses are carried out after a break of 4-6 weeks.

Side effects

With intracavitary administration of the drug, there may be:

• Chills;
• Headache;
• Increase in body temperature;
• Photosensitivity (pigmentation of the skin when exposed to sun rays);
• convulsions;
• Dyspeptic phenomena;
• allergic reactions.

External use of Dioxidine can cause peri-wound dermatitis.

special instructions

Dioxidine is not used in pediatric practice. Before starting a course of therapy, it is recommended to conduct a drug tolerance test. For this purpose, 10 ml of a 1% solution is injected into the cavity. If within 3-6 hours side effects does not occur (fever, chills, dizziness), you can start a course of treatment.

Dioxidine is indicated only for severe forms infections or in case of ineffectiveness of other antibacterial medicines (carbapenems, fluoroquinolones, cephalosporins II-IV generations).

In chronic renal failure, treatment with Dioxidin should be started with the minimum allowable dose.

If it appears on the skin age spots the duration of the administration of a single dose of Dioxidin should be increased to 1.5-2 hours, the dose itself should be reduced and antihistamines prescribed. If the measures taken are ineffective, Dioxidine treatment should be discontinued.

If precipitation of crystals is observed in ampoules with a solution of Dioxidin (as a rule, when the solution is stored at a temperature below 15 ° C), the ampoules should be heated in a boiling water bath until the crystals are completely dissolved (the solution should become transparent). If, when the drug is cooled to 36-38 ° C, no crystals form, the drug is suitable for use.

Analogues

Analogues of Dioxidin, which have a similar pharmachologic effect, are the drugs: Algofin-Forte, Givalex, Tiberal, Svebidin, Vijaysar, Proalor, Aknestop, Tsiprolet, Amoxil-K, Ornidazole, Losterin, Differin, Viferon, Trinefron, Baziron AS, Zinerit.

Terms and conditions of storage

According to the instructions, Dioxidin belongs to list B drugs, which should be stored in a dry, cool, dark place, protected from children. The shelf life of the drug is 2 years from the date of issue.

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Dioxidine is antibacterial drug with a wide spectrum of action, it has an antibacterial, bactericidal effect on various pathogens - staphylococci, Pseudomonas aeruginosa, pathogenic anaerobes and some strains of bacteria that are resistant to other antibiotics.

The drug is available in the form of a solution intended for intracavitary and external use. The solution has a concentration of 1% and is available in 10 ml transparent glass ampoules, in cardboard packs with detailed instruction. The contents of the ampoule are sterile, the medicine may have a yellowish or greenish tint.

The active substance is Hydroxymethylquinoxaline dioxide.

The active substance Dioxidin effectively relieves purulent-inflammatory processes, the causative agents of which are Klebsiella, Salmonella, Staphylococcus, dysentery bacillus, Proteus vulgaris, Pseudomonas aeruginosa, pathogenic anaerobes and streptococci.

The use of Dioxidin ampoules is much faster in the process of healing and cleansing of wound surfaces. In addition, when using the drug, reparative regeneration is activated.

Release form

The drug is produced in the form of a solution and ointment for external use.

• Dioxidine in ampoules of 0.5% and 1% solution. For local and intracavitary use. 10 ml and 20 ml in an ampoule, 10 pieces per pack;
• Ointment Dioxidin for external use 5% in tubes of 25 mg, 30 mg, 30 mg, 50 mg, 60 mg, 100 mg.

Indications for use

What does Dioxidin help with? According to the instructions, the drug is prescribed in the following cases:

• purulent bacterial infections caused by sensitive microflora with the ineffectiveness of other chemotherapeutic agents or their poor tolerance.

Outdoor use

• superficial and deep wounds of various localization;
• long-term non-healing wounds and trophic ulcers;
• phlegmon of soft tissues;
• infected burns;
• purulent wounds in osteomyelitis.

Intracavitary administration

• purulent processes in the chest and abdominal cavity;
• at purulent pleurisy, pleural empyema, lung abscesses, peritonitis, cystitis, wounds with deep purulent cavities (soft tissue abscesses, phlegmon of pelvic tissue, postoperative wounds of the urinary and biliary tract, purulent mastitis).

Intravenously

• septic conditions (including in patients burn disease);
• purulent meningitis;
• purulent-inflammatory processes with symptoms of generalization.

Instructions for use Dioxidin (ampoules \ ointment), dosages

Ointment Dioxidin is intended exclusively for local application. According to the instructions, the drug is applied to the affected area thin layer- 1 per day. The course of treatment is up to 3 weeks.

Dioxidine in ampoules

Ampoules are intended for external or intracavitary use. As a rule, the drug is prescribed in a hospital setting. Before using the solution, it is necessary to do a tolerance test. In the absence of side effects within 4 hours, the drug can be used for treatment.

According to the instructions for use, a 0.1-1% Dioxidine solution is used for external use. To obtain a 0.1-0.2% solution, it is necessary to dilute the ampoule to the required concentration with a sterile isotonic saline sodium chloride.

For the treatment of purulent and infected superficial wounds it is necessary to apply napkins moistened in a 0.5-1% solution of the drug to the wound. Deep wounds after treatment are plugged with swabs moistened with a 1% solution.

For the treatment of deep wounds in osteomyelitis, baths are made from a 0.5-1% solution of the drug, or the wound surface is treated with a solution for 15-20 minutes, followed by a dressing on the wound moistened with a 1% solution of the drug.

A solution of the drug 0.5-1% is used to prevent infections in the postoperative period.

Treatment with Dioxidin is allowed to be carried out daily for 1.5-2 months.

With intracavitary administration, Dioxidin solution is injected into the purulent cavity using a syringe, tube or catheter. Maximum daily dosage is 70 ml of 1% solution.

As a rule, they are administered once a day, but two-time administration is also allowed according to indications. Treatment continues for 3 weeks.

Dioxidine in the nose is used for suspected allergic or vasomotor rhinitis, or when there is reason to suspect sinusitis. Buried in the amount of a few drops in each nostril several times. Drops reduce the treatment time, prevent complications, and do not dry out the nasal mucosa.

Solution for intravenous drip

The drug is diluted with 0.9% isotonic sodium chloride solution or 5% dextrose solution to a concentration of 0.1-0.2%.

The daily dose is administered in 3-4 doses (fractional administration) or once, at a rate of 60-80 drops / min for 30 minutes.

• In chronic purulent processes in the lungs - a daily dose of 500-600 mg (100-120 ml of a 0.5% solution).
• In the treatment of purulent urinary tract infections - a daily dose of 200-400 mg (40-80 ml of a 0.5% solution).
• In severe septic conditions, the daily dose is 600-900 mg (divided into 3-4 doses).
• With purulent meningitis, the daily dose is 600-700 mg (20-140 ml of a 0.5% solution).

Dioxidin in the ear

Dioxidin solution is prescribed to patients as an independent medicine or as part of complex therapy at purulent otitis media and distribution pathological process to the Eustachian tube.

In a hospital, the ear cavity is washed with a solution of the drug, after which a cotton or gauze turunda is inserted into the ear for 20-30 minutes.

Side effects

The instruction warns of the possibility of developing the following side effects when prescribing Dioxidin:

• temperature increase.
• headache.
• chills.
• jerky muscle contractions.
• various manifestations of allergic reactions ( skin rashes, itching and burning, redness of the skin).
• vomiting or nausea.

With external use, the development of near-wound dermatitis is possible. In some patients, pigment spots appeared on the skin after using the drug. In such cases, reduce the dosage, increase the time of administration of a single dosage, prescribe antiallergic drugs. If such activities do not lead to the disappearance side effects, then you should stop using Dioxidine.

Contraindications

It is contraindicated to prescribe Dioxidin ampoules in the following cases:

• individual intolerance to the drug;
• the period of pregnancy and breastfeeding;
• insufficiency of the adrenal cortex;
• pronounced disorders in the work of the kidneys, acute renal failure;
• children's age up to 12 years.

Overdose

With prolonged use of the solution intravenously or intracavitary, overdose symptoms may develop - inhibition of kidney function and disruption of vital organs.

In case of accidental ingestion of too large doses of the drug, the patient should remain under the supervision of specialists with the control of important vital parameters. If necessary, symptomatic treatment is carried out.

With the development of allergic reactions are prescribed antihistamines reduce dosage or stop therapy completely.

Dioxidin analogues, price in pharmacies

If necessary, you can replace Dioxidin with an analogue according to therapeutic effect are the drugs:

1. galenophyllipt,
2. Hexamethylenetetramine,
3. zyvox,
4. Sanguiritrin,
5. Urophosphabol,
6. zenix,
7. Amizolid,
8. Dioxicol,
9. quinoxidine.

ATX code:

• Viumksidin,
• galenophyllipt,
• impact,
• Calcex,
• Urotravenol.

When choosing analogues, it is important to understand that the instructions for use of Dioxidin in ampoules, the price and reviews of drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.

Price in Russian pharmacies: Dioxidin 10mg / ml solution 5ml 10 ampoules - from 216 rubles, a solution of 1% 10 ml 3 ampoules - from 240 rubles, you can buy 1 ampoule of a solution of 0.5% 5 ml from 42 rubles, according to 593 pharmacies.

Keep out of the reach of children, protected from light at a temperature of +18…+25 °С. Shelf life - 2 years.

Conditions for dispensing from pharmacies - by prescription.

Dioxidine is an antibacterial drug that Soviet time actively used in hospitals. Today it is also used, but without fanaticism and with good reason. Indeed Hydroxymethylquinoxylindioxide (this is what the international generic name Dioxidine) in large doses has a high degree toxicity, which means that it requires a competent and balanced approach when prescribing.

What kind of "beast" is Dioxidin?

In the middle of the last century, a potent substance with a long "name" was a success in many hospitals in the country. The basis is a yellow-green powder, odorless. bactericidal agent destroys the membranes of harmful cells and prevents their reproduction.

The success of the drug among Soviet doctors was explained high efficiency to eliminate microorganisms that cause purulent processes. A powerful antiseptic easily copes with streptococci, staphylococci, Pseudomonas aeruginosa and pathogenic anaerobes.

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The ability to fight pathogens that develop without the participation of oxygen distinguishes Dioxidin from other antibacterial drugs. By the way, scientists have not been able to determine how he does it so far. It is only known that the drug prevents the formation of DNA and disrupts the structure of enemy cells.

What do the studies say?

Clinical trials were conducted in 24 multidisciplinary hospitals. In total, the experiments lasted 15 years. The results were impressive. The studies involved patients with severe infections that could not be cured with antibiotics. The use of 0.5%, 0.1%, and 1% Dioxidin in patients with purulent pathologies of the urinary system, ENT organs, burns, osteomyelitis gave positive result in 85% of cases.

Maximum productivity was achieved in the treatment of extensive burns, deep trophic ulcers and open fractures, complicated by suppuration of soft tissues. After several days of treatment, the spread of the infection stopped, healing began.

It turns out that the percentage of Dioxidine has great importance. So, with osteomyelitis, a 0.1% solution turned out to be the most effective, with festering wounds - 1%. In the first stage of infection wound process Dioksidina 5% ointment helped well.

In patients with severe bacterial lesions of the respiratory and urinary tract, the solution was administered intravenously 2 times a day. Good therapeutic effect achieved in 88% of cases. More better result found in patients with peritonitis. Intracavitary infusions of 0.5% solution gave a 100% result.

Doctors of the All-Russian Center for Surgery B. V. Petrovsky prescribed Dioxidin in ampoules to prevent complications after operations on the abdominal organs. This made it possible to reduce the number of postoperative purulent inflammation. Experts noted excellent tolerance. Side effects have only been reported with intravenous administration, no side effects were noted with intracavitary and external use.

At the Institute of Neurosurgery N. N. Burdenko, the antiseptic became a real discovery. Endolumbar injection did not cause convulsions, which is very valuable in purulent pathologies of the brain tissue.

The solution can be used at home, but under strict control of the Dioxidin dosage. Inhalations are prescribed for lung abscesses, pleural empyema, severe inflammation of the bronchi. Dioxidine for sinusitis, frontal sinusitis, is rarely prescribed - with a protracted course of the disease and the appearance of resistance (immunity) to other (weaker) drugs.

The concentrated solution is not poured into the nebulizer, it is diluted with saline. How to breed Dioxidin correctly?

• ampoules with a 1% solution are diluted in a ratio of 1:4;
• ampoules with a 0.5% solution are diluted in a ratio of 1:2.

One inhalation will require 3 ml. Leftovers can be stored in the refrigerator for up to 12 hours. The only moment, before inhalation, it is advisable to remove Dioxidin from the refrigerator in advance so that it warms up naturally at room temperature.

Dioxidine's analogs

What analogues of Dioxidine can be found in pharmacies?

• Dioxysept. It is identical to Dioxidin in all respects: action, method of application, indications, side effects;
• Dioxicol. Available in the form of an ointment. In addition to Dioxidin, it contains Trimecaine, Methyluracil, Polyethylene oxide. It is well tolerated, practically does not cause side effects;
• quinoxidine. In fact, this drug is a tablet form of Dioxidin. It is prescribed for multiresistant urinary tract infections. It is characterized by a high frequency of side effects digestive system;
• Urotravenol. Consists of Dioxidin, Glycine and water. Supplied in sterile 10 liter containers. Used in hospitals for intracavitary administration.

Conclusion: Dioxidine is a powerful antiseptic, which is prescribed in special occasions. In large doses, it is toxic, but if medical recommendations are followed, it helps where even the most modern antibiotics are powerless.

Country of origin

Product group

Antibacterial drug, quinoxaline derivative

Release forms

• 10 ml - ampoules (10) - cardboard boxes 10 ml - ampoules (10) - cardboard boxes. 10 ml - ampoules (10) - packs of cardboard. 3 ampoules of 10 ml per pack 3 ampoules of 5 ml per pack 30 g - dark glass jars (1) - cardboard packs. 60 g - dark glass jars (1) - packs of cardboard. 100 g - dark glass jars (1) - packs of cardboard. 5 ml - ampoules (10) - cardboard boxes. 5 ml - ampoules (10) - packs of cardboard. 10 ml - ampoules (10) - cardboard packs 5 ml - ampoules (10) - cardboard packs. 10 ml - ampoules (10) - packs of cardboard. 5 ml - ampoules (5) - packs of cardboard. 5 ml - ampoules (5) - packs of cardboard. 5 ml - ampoules (10) - packs of cardboard. 5 ml - ampoules (5) - blister packs (1) - cardboard packs. 5 ml - ampoules (5) - blisters contour 5 ml - polymer dropper bottles (1) - cardboard packs. 10 ml bottle sealed with a rubber stopper and metal cap,

Description of the dosage form

• Eye drops 0.1% in the form of a clear or almost clear solution from colorless to light yellow. Ointment for external use 5% Solution for intravenous administration of a light yellow color with a greenish tint, transparent Solution for intracavitary and external use Solution for intracavitary and external use 1%, light yellow color with a greenish tint, transparent. Solution for intracavitary and external use 1% light yellow with a greenish tinge, transparent. Solution for intracavitary and external use of a greenish-yellowish color, transparent. Solution for infusion and external use

pharmachologic effect

Pharmacokinetics

Special conditions

Compound

• 1 ml hydroxymethylquinoxaline dioxide 10 mg (dioxidine) Excipients: water d / i - up to 1 ml. 1 ml hydroxymethylquinoxaline dioxide 10 mg (dioxidine) Excipients: water for injection - up to 1 ml. 1 ml diclofenac sodium 1 mg Excipients: macrogol glyceryl ricinoleate ( Castor oil polyethoxylated), trometamol, disodium edetate dihydrate, mannitol, benzalkonium chloride, hydrochloric acid (1M solution), purified water. hydroxymethylquinoxaline dioxide 10 mg/ml Excipients: water for injection. hydroxymethylquinoxaline dioxide 5 mg/ml Excipients: water for injection. hydroxymethylquinoxaline dioxide 50 mg hydroxymethylquinoxaline dioxide 10 mg/ml Excipients: water for injection. Hydroxymethylquinoxylindioxide (dioxidine) 0.5; water for injection up to 1l Hydroxymethylquinoxylindioxide (dioxidine) 10g; water for injection Hydroxymethylquinoxylindioxide (dioxidine) 10g; water for injection up to 1l Hydroxymethylquinoxylindioxide /dioxidine/ 5.0 Auxiliary substances: water for injection up to 1l Hydroxymethylquinoxylindioxide 5mg; Auxiliary in-va: water

Dioxidine indications for use

• For intravenous administration: - septic conditions (including in patients with burn disease); - purulent meningitis; - purulent-inflammatory processes with symptoms of generalization. For intracavitary administration - purulent processes in the chest and abdominal cavity, including: - purulent pleurisy; - pleural empyema; - peritonitis; - cystitis; - empyema of the gallbladder; - prevention of infectious complications after catheterization Bladder. For external, local use: - wound and burn infection (superficial and deep purulent wounds of various localization, long-term non-healing wounds and trophic ulcers, soft tissue phlegmon, infected burns, purulent wounds with osteomyelitis); - wounds with deep purulent cavities (lung abscess, soft tissue abscesses, phlegmon of pelvic tissue, postoperative wounds of the urinary and biliary tract, purulent mastitis); - pustular diseases skin.

Dioxidine contraindications

• - hypersensitivity to the components of the drug. The drug should be used with caution when bronchial asthma caused by taking acetylsalicylic acid, epithelial herpetic keratitis (including history), diseases that cause blood clotting disorders (including hemophilia, prolongation of bleeding time, tendency to bleeding), pregnancy (I, II trimester), as well as in pediatric and elderly patients.

Dioxidine dosage

• 0.5% 1% 10 mg/ml 10 mg/ml 5% 5 mg/ml

Dioxidine side effects

• Local reactions: burning eyes, blurring visual perception(immediately after instillation), clouding of the cornea (thorn), iritis. From the digestive system: nausea, vomiting. Allergic reactions: itching in the eyes, hyperemia, angioedema face, fever, chills, photosensitivity, skin rash(mainly erythematous, urticaria), erythema multiforme exudative.

drug interaction

Overdose

Storage conditions

• store in a dry place
• store in a cool place 5-15 degrees
• store at room temperature 15-25 degrees
• keep away from children
• store in a place protected from light

Dioxidin 1%, 0.5% solution (Solutio Dioxydini 1%), instructions for use

Average price for Dioxidine in Russia:
solution 0.5% 10 ampoules - 148 rubles. (from 90 rubles)
solution 1% 10 ampoules - 328 rubles. (from 324 rubles)

Tradename: Dioxidine

Chemical Name: 2,3-bis-(hydroxymethyl)quinoxaline 1,4-di-N-oxide

Dosage form: Solution for intracavitary administration and external use

Compound:

Dioxidine contains: 1,4-dioxide 2,3-bis-(hydroxymethyl)quinoxaline, preservative and water for injection. It is a clear, greenish-yellow liquid of a bitter taste, odorless. The presence of crystals is allowed when stored below 15 °C. Before using the drug, they are dissolved by heating the contents of the vial in a boiling water bath. Packed in bottles of 100 ml.
Description: Greenish yellow, clear liquid

Pharmacotherapeutic group: Antimicrobial agent, quinoxaline

ATC code:

Pharmacological properties of Dioxidine

A broad-spectrum antibacterial drug from the group of quinoxaline derivatives, has chemotherapeutic activity in infections caused by Proteus vulgaris, dysentery bacillus, Klebsiella, Pseudomonas aeruginosa, salmonella, staphylococci, streptococci, pathogenic anaerobes (including pathogens of gas gangrene), acts on bacterial strains, resistant to other chemotherapy drugs, including antibiotics.

The development of drug resistance in bacteria is possible. When administered intravenously, it is characterized by a small therapeutic breadth, and therefore it is necessary to strictly adhere to the recommended doses. Treatment of burn and purulent-necrotic wounds promotes faster cleansing of the wound surface, stimulates reparative regeneration and marginal epithelization, and has a positive effect on the course of the wound process.

Pharmacokinetics

When applied externally, it is partially absorbed from the wound or burn surface, excreted by the kidneys.

Indications for use Dioksidina

Purulent bacterial infections caused by sensitive microflora with the ineffectiveness of other chemotherapeutic agents or their poor tolerance.

External use - superficial and deep wounds of various localization, long-term non-healing wounds and trophic ulcers, soft tissue phlegmon, infected burns, purulent wounds with osteomyelitis.

Intracavitary administration - purulent processes in the chest and abdominal bands. with purulent pleurisy, pleural empyema, lung abscesses, peritonitis, cystitis, wounds with deep purulent cavities (soft tissue abscesses, phlegmon on wounds with deep purulent cavities (soft tissue abscesses, phlegmon of the pelvic tissue, postoperative wounds of the urinary and biliary tract, purulent mastitis, etc.).

Contraindications to the use of dioxidine.

• individual intolerance;
• a history of adrenal insufficiency;
• pregnancy, lactation;
• childhood;
• with caution - renal failure

Method of administration and doses of dioxidine (instructions for use) :

Dioxidin is prescribed in a hospital setting. Applied externally, intracavitary.

A 1% solution of dioxidine cannot be used for intravenous administration, due to the instability of the solution when stored at low temperatures.

Dioxidin - instructions for use:outdoor use . Apply 0.1% - 1% solutions of dioxidine. To obtain 0.1-0.2% solutions, ampoule solutions of the drug are diluted to the desired concentration with sterile isotonic sodium chloride solution or water for injection. For the treatment of superficial infected purulent wounds, napkins moistened with a 0.5-1% solution of dioxidine are applied to the wound. After treatment, deep wounds are loosely packed with swabs moistened with a 1% solution of dioxidine, and in the presence of a drainage tube, from 20 to 100 ml of a 0.5% solution of the drug is injected into the cavity.

For the treatment of deep purulent wounds in osteomyelitis (wounds of the hand, foot), 0.5-1% solutions of the drug are used in the form of baths or a special treatment of the wound with a solution of the drug is carried out for 15-20 minutes (introduction of the solution into the wound for this period) followed by application dressings with 1% dioxidine solution.

Dioxidine in the form of 0.1-0.5% solutions can be used to prevent infection after surgery. According to the indications (patients with osteomyelitis) and with good tolerance, treatment can be carried out daily for 1.5-2 months.

Doxydin - instructions for use: intracavitary administration . In the purulent cavity, depending on its size, from 10 to 50 ml of a 1% solution of dioxidine is injected per day. A solution of dioxidine is injected into the cavity through a catheter, drainage tube or syringe.

The maximum daily dose for injection into the cavity is 70 ml of a 1% solution.

The drug is injected into the cavity usually once a day. According to the indications, it is possible to administer a daily dose in two divided doses. With good tolerance and indications, the drug can be administered daily for 3 weeks or more. If necessary, after 1-1.5 months, repeated courses are carried out.

Dioxidine side effects

With intracavitary administration, headache, chills, fever, dyspeptic disorders, convulsive muscle contractions, allergic reactions, photosensitizing effect (appearance of pigmented spots on the body when exposed to sunlight) are possible. When applied externally - peri-wound dermatitis. special instructions

Dioxidine is prescribed only for adults. Before starting the course of treatment, a drug tolerance test is carried out, for which ]P ml]% solution is injected into the cavity. In the absence of side effects within 3-6 hours (dizziness, full-time, fever), a course of treatment is started.

Dioxidine is prescribed only for severe forms of infectious diseases or for the ineffectiveness of other antibacterial drugs, including cephalosporins of II-1V generations, fluoroquinolones, carbapenems.

In chronic renal failure, the dose is reduced.

When age spots appear, the duration of a single dose is increased to 1.5-2 hours, the dose is reduced, antihistamines are prescribed, or dioxidine is canceled.