Hormonal drug Oxytocin: instructions for use, indications for injections, possible side effects. Features of the use of oxytocin

Oxytocin is intended to increase excitability and enhance the contractile properties of the uterine muscles. Naturally taken for stimulation labor activity. In cases where one’s own “strength” is not enough. Increased muscle contraction occurs due to oxytocin increasing the permeability of the myometrial cell membrane to potassium ions. Thus, its potential decreases and excitability increases.

ATX code

H01BB02 Oxytocin

Active ingredients

Oxytocin

Pharmacological group

Hormones of the hypothalamus, pituitary gland, gonadotropins and their antagonists

Uterotonics

pharmachologic effect

Uterotonic drugs

Indications for use Oxytocin

Indications for use Oxytocin – weakening of labor. Typically, the product is used during a caesarean section, during the operation itself. In addition, the main indications for its use are hypotension or atony of the uterus after childbirth.

The medication is also used for abortions, if it needs to be performed for a sufficiently long time. long term. This will cause premature labor. For hypotonic uterine bleeding in postpartum period the product is actively used. The reason for taking it may be stagnation of milk in the early postpartum period, as well as too painful premenstrual syndrome. Which is characterized by severe swelling. The product is also used for weight gain. In general, the spectrum of action of the drug is very wide. It is used exclusively by women and only on the recommendations of a doctor. Oxytocin is mainly used to enhance labor during early discharge of amniotic fluid and stimulate the uterus.

Release form

The release form is ampoules, the product is administered by injection. This medication is a synthetic hormonal medication. It is an analogue of the polypeptide hormone of the posterior lobe of the pituitary gland.

You can purchase it at different dosage. So, it is produced in the form of an injection solution in 1 ml ampoules. It contains 5 units of oxytocin. One package can contain 5, 10 and 50 ampoules.

There is also a slightly different dosage. One ampoule may contain 2 ml of active substance. In this form, the package contains 5 ampoules. There are no other variations of “packaging”. The medicine is not made in the form of tablets. He must provide fast action, and only intravenous administration of the drug can allow this to be done. That is why Oxytocin is available in the form of an injection solution. The required dosage of the medication is prescribed by the doctor; based on the situation, it is recommended to administer one or another amount. Therefore, a specialist also decides in which variation to buy the product.

Pharmacodynamics

Pharmacodynamics Oxytocin is a hormone of the posterior pituitary gland. It is designed to have a stimulating effect on the smooth muscles of the uterus. This results in an increase in contractile activity and, to a lesser extent, myometrial tone. This is very important for weak labor.

In small doses, the drug can increase the frequency and amplitude of uterine contractions. IN increased dosage When administered repeatedly, the drug helps to increase the tone of the uterus. In addition, its contractions become more frequent and intensified, even tetanic.

In addition, there is an increase in the secretion of prolactin, as well as a reduction in the myoepithelial cells surrounding the alveoli of the mammary gland. Thereby promoting increased milk production. The drug has weak vasopressin-like antidiuretic properties. That is why the remedy has wide range actions and is used everywhere. Oxytocin is a medication that is widely used in obstetric practice.

Pharmacokinetics

Pharmacokinetics of Oxytocin after administration T1/2 from plasma ranges from one to several minutes. Metabolism occurs in the liver. During pregnancy, a specific enzyme oxytocinase appears in the plasma, inactivating endogenous and exogenous oxytocin. In addition to plasma, it is also found in target organs.

It is worth noting the fact that a small amount of it is excreted unchanged by the kidneys. This medication is widely used in obstetrics. It stimulates uterine contractions and maintains its tone. This is especially important when labor is weak. A small amount of medication can help relieve this process. In some cases, the drug is used to perform abortion on later. This causes premature birth.

This medicine is really in demand. After all, it is not possible to give birth to a child on your own in all cases. Oxytocin produces stimulation and thereby helps in this matter.

Use of Oxytocin during pregnancy

The use of Oxytocin during pregnancy is acceptable, but only when necessary. Basically, this remedy is widely used to stimulate labor. In some cases, the tone of the uterus and the frequency of its contractions are not enough to independently begin the labor process. That is why this hormone is injected into the woman. It is also widely used during caesarean section.

In other cases, a pregnant girl should not take the product. It should be noted once again that the main activity of the medication is aimed at enhancing the birth process. Therefore, taking a remedy unnecessarily can lead to the onset of premature birth. Usually this phenomenon is achieved when performing an abortion at a long term. Use this remedy only necessary under the guidance of a specialist. Self-use is prohibited; this can lead to the development of serious complications. Oxytocin is used exclusively in obstetric practice.

Contraindications

Contraindications to the use of Oxytocin are primarily increased hypersensitivity to certain components of the medication. In this case, serious complications may develop. Including severe allergic reactions. For a girl in this position, this is extremely unacceptable.

People who have a narrow pelvis should not take the product. In this case, independent labor is prohibited. A woman simply cannot give birth to a child, so it is necessary to resort to a caesarean section.

If the size of the fetal head does not correspond to the size of the pelvis, it is prohibited to use the product. A similar prohibition applies to cases where the child has taken incorrect position in the womb. This means a transverse or oblique arrangement. If placenta previa is complete and there is a risk of uterine rupture, the product cannot be used; this can lead to the development of serious complications. That is why Oxytocin should be taken exclusively according to the recommendations of the attending physician.

Side effects of Oxytocin

Side effects Oxytocin can cause. Basically everything manifests itself in the form of nausea, vomiting and arrhythmia. The latter phenomenon can also develop in the fetus. It is possible that the heart rate may slow down in both the mother and the child.

Blood pressure may rise significantly and subarachnoid bleeding may begin. Against this background, hypotension and shock cannot be ruled out. Water retention in the body is possible, even to the point of poisoning. Usually this phenomenon occurs with too frequent and prolonged administration of the drug. This can happen against the background of an allergic reaction, which is caused by intolerance to some components of the medication.

There may be sudden contractions with further development intrauterine hypoxia. All these phenomena are fraught with serious consequences. Moreover, this applies not only to the mother’s body, but also to the child. That is why any intervention must be carried out under the supervision of a doctor. Increased dose or failure to ignore some important points can lead to serious complications. Oxytocin in higher doses capable of harm.

Directions for use and doses

The method of administration and dose should be prescribed by the attending physician. The drug is administered intravenously and intramuscularly into the wall or vaginal part cervix. Injection into the nose is possible.

For intravenous drip administration, 1 ml of the product is sufficient. However, it is not introduced into pure form, but diluted. The drug is diluted in 500 ml of 5% glucose solution.

To stimulate labor, the drug is administered intramuscularly, 1 unit at an interval of 30–60 minutes. In this case, much depends on the reaction of the uterus. It is advisable to administer the medication intravenously by drip method, 1–5 units in 300–500 ml of 5% glucose solution. But at the same time, uterine contractions and fetal heartbeat must be monitored. This is done before the end of childbirth and after separation of the placenta.

With weak labor or protracted labor the drug is taken in doses of 0.5–1 IU with an interval of 60 minutes, depending on the obstetric situation. During childbirth in breech 2–5 units of the drug are administered.

For hypotension and uterine atony, 5–10 units of Oxytocin are prescribed intravenously in 10–20 ml of 40% glucose solution. To stimulate lactation, the drug is administered intramuscularly or into the nose, 0.5 units 5 minutes before feeding. If necessary, the injection is repeated. At premenstrual syndrome- into the nose, from the 20th day of the cycle to the 1st day of menstruation.

As a prophylaxis and treatment of hypotonic uterine bleeding in the postpartum period, the medication is administered intramuscularly at a dose of 3–5 units. Exact dosage In any case, oxytocin is prescribed by a doctor.

Overdose

There were no cases of overdose observed. This drug is not capable of causing serious complications if taken in the prescribed dosage. Only a sharp increase in dose can cause negative reactions. This is primarily due to the high concentration of the drug in the blood plasma. Therefore, it is impossible to increase the dose unless necessary.

The drug should be administered strictly under the supervision of a physician. This will avoid serious consequences further. If strange symptoms develop, the administration of the medication is stopped. But accept this decision should the doctor. After all, if labor is weak, it is necessary to complete what was started in any case. This should occur either under the administration of this drug, or during a cesarean section. In this case, all possible risks are weighed, and based on this, a decision is made. correct solution. Oxytocin really helps many women, but in order not to cause harm to the body of the mother and child, it must be used carefully, without deviating from the given dose.

Interactions with other drugs

Interactions of Oxytocin with other drugs in simultaneous use with inhaled anesthetics may enhance hypotensive effect the drug and weakening of its stimulating effect on the uterus. This can significantly complicate the process and lead to the impossibility of an independent birth process. In this case, you will have to resort to a caesarean section.

Prostaglandins potentiate the stimulating effect of oxytocin on the uterus. The drug itself is capable of potentiating the pressor effect of sympathomimetic drugs. Therefore, before administering this drug, you must make sure that the woman is not taking any other medications. Moreover, it is extremely unacceptable to use simultaneous administration of medications that have the same effect. This can lead to serious consequences. Oxytocin is a strong medicine that can not only improve the condition and “accelerate” labor, but also, on the contrary, worsen the situation.

Oxytocin is a synthetically produced hormone from the hypothalamus.

As an injection solution, it helps to enhance contraction and increase the excitability of the smooth muscles of the uterus, and therefore is often used to terminate pregnancy, as well as as a stimulant of labor.

Instructions for using Oxytocin for injections will provide correct use drug and will help avoid negative consequences.

The injection solution Available in 1 ml ampoules containing 5 IU of Oxytocin. In addition to the main active substance, it also contains some auxiliary components - distilled water, chlorobutanol, and a solution of acetic acid.

There are several indications for the use of Oxytocin solution:

• stimulation and initiation of labor;
• termination of pregnancy in the presence of serious medical indications– in particular, such as, fetal death fetus, post-term pregnancy, Rh conflict between mother and fetus, water breaking earlier than expected, preeclampsia, etc.;
• acceleration of uterine contractions during cesarean section, as well as in the early postpartum period;
• postpartum hypolactation;
• consequences of incomplete abortion;
• premenstrual syndrome, which is accompanied by weight gain and significant swelling;
• prevention of bleeding after abortion or curettage.

This drug, which is a synthetic hormone, does not contain impurities of other hormones, and therefore affects myometrial cells more selectively than its natural analogue.

As a result of the use of Oxytocin, the frequency of uterine contractions significantly increases, and they also become longer. The production of the lactogenic hormone prolactin is also activated, thereby stimulating milk secretion.

Contraindications

The instructions for using Oxytocin injections (reviews after use are at the end of the material) indicate a number of contraindications that are important to read.

The use of Oxytocin injections is unacceptable in the following cases:

• excessive sensitivity to the main active ingredient or its absolute intolerance;
• violations of cardio-vascular system in severe forms;
• significant increase blood pressure;
• uterine ruptures that pose a threat to health and life;
• significant discrepancies between the sizes of the fetus and the pelvis of the expectant mother;
• too narrow pelvic area;
• incorrect position of the fetus - oblique or transverse;
• there is a suspicion of premature placental abruption;
• intrauterine fetal hypoxia;
• uterine contractions that are hypertensive in nature;
• severe preeclamptic toxicity.

In what cases is it necessary to take an Anti-Mullerian hormone test and when is the best time to do this, read in.

Dosage and overdose

Oxytocin injection solution is intended exclusively for intravenous administration. Before using it, pregnant women undergo a test to determine the tolerability of the active substance - this makes it possible to assess the condition of the fetus and placenta with maximum accuracy, as well as timely identify the presence of certain complications.

Oxytocin

To prepare the infusion solution, it is necessary to dilute Oxytocin in a 5% glucose solution or 9% sodium chloride solution - its volume in any case should be 500 ml.

In order to stimulate labor, an infusion is usually prescribed at a rate of 0.001-0.002 IU per minute (5-8 drops each). Then, observing a 30-minute interval, this rate is gradually increased until vigorous labor is established - that is, at three to four contractions every ten minutes. At this stage, it is recommended to administer 40 drops of solution per minute.

To induce labor this drug also administered intramuscularly.

In this case, the dosage can range from 0.5 to 2.0 IU. Such injections can be given at intervals of 30 to 60 minutes.

To prevent the occurrence postpartum hemorrhage appoint intramuscular injections 5-8 IU of the drug for three days in a row.

During a cesarean section, and precisely immediately after the fetus is removed, injections are made into the wall of the uterus. The dosage of the drug in this case can vary from 3 to 5 IU, it is prescribed by the doctor in individually.

In order to terminate pregnancy, Oxytocin is prescribed for periods not exceeding 4-5 weeks. Medical abortion of this type should be carried out exclusively in a clinical setting under the supervision of a doctor. The dosage in this case is prescribed by the doctor based on individual characteristics and the condition of a woman.

When carrying out injections and infusions using the hormonal drug Oxytocin, overdose should be avoided. Administration of the drug in an amount exceeding the permissible limit may lead to adverse consequences in the form of jaundice in a newborn, which is directly related to drug hemolysis.

Side effects

The use of the drug Oxytocin can lead to a certain number of side effects affecting both the mother and the fetus. Despite the fact that these phenomena occur in extremely rare cases, it is necessary to have an idea about them.

Side effects caused by Oxytocin injections or infusions may affect various systems woman's body:

• on the cardiovascular system may cause arterial hypertension, arrhythmia, reflex tachycardia and bradycardia;
• from the reproductive system, hematomas may occur in the pelvic area, as well as significant bleeding after childbirth;
• from the outside nervous system– headaches and dizziness;
• from the digestive system – nausea and vomiting;
• skin rashes and redness accompanied by itching;
• allergic reactions, including those of an anaphylactic nature.

The most important side effects that affect the fetus include:

• signs of jaundice;
• hemorrhages in the retina;
• arrhythmia;
• sinus tachycardia;
• bradycardia;
• damage to the central nervous system and brain.

Prevent side effects Careful monitoring by a doctor will help, who can promptly identify deviations and take appropriate measures.

What is Oxytocin? Let's consider its release form, expected action and effect, features of use, indications and contraindications. What do doctors and patients who have tried it say about the product?

Oxytocin – hormonal drug of synthetic origin. The hormones included in its composition have the same characteristics as natural hormones produced by the human body. Used to stimulate the antispasmodic work of the uterus. Oxytocin is used to terminate pregnancy in the initial stages.

Forms

The product is sold under various names:

• Syntocinon;
• Ipofamin;
• Pitocin;
• Utedrin and so on.

This is a solution for parenteral use. It is administered by injection through a vein or intramuscularly. In some cases, subcutaneous administration of the drug is acceptable. The form of the solution for injection is due to the fact that the substance is destroyed in gastrointestinal tract. For this reason, oxytocin tablets are not as effective for medical abortion. The tablets are usually indicated to stimulate uterine contractions after childbirth or abortion.

Action of oxytocin

The action of the product is to improve the functioning of the uterine muscles. This provokes spasmodic uterine contractions. Injections of the drug into a vein cause instant reaction, expressed in increased uterine spasms. The spasms stop only after an hour and a half.

At intramuscular injection the drug, spasms begin after five minutes. They last for 2-3 hours.

Before use, you should read the instructions. The woman feels the effect of the injection almost immediately. This is expressed in a pulling pain syndrome in the lower abdomen. Sometimes there may be a feeling of heaviness and shooting in the lumbar region. Such sensations indicate the correct course of the abortion.

Complications may arise. At the same time, the patient’s blood pressure decreases and the heart rate decreases. If such reactions occur, increased monitoring by medical personnel is required.

After the first dose is administered, the woman should move. The measure of motor movements depends on what sensations the patient experiences. If this strong pain, movements can be more gentle. This measure is needed for a simpler and faster abortion.

Discharge of bloody mucus from the genital tract occurs an hour after the injection is given. This is considered a sign of the onset of miscarriage. The secretion of mucus marks the moment at which medical staff should provide enhanced control over the course of abortion. With such an interruption of pregnancy, the woman feels pain syndrome pulling character.

After the procedure, bleeding occurs, which is normal. It can last from an hour to a couple of days. All this time, injections of the medicine continue. Their dose is selected individually. It all depends on the course of the abortion and the patient’s well-being. Usually the medicine is injected into the muscle once a day.

Instructions for use

The instructions for the product indicate that it can be used to terminate a long-term pregnancy. Injections can be used from the 20th week of pregnancy. They are indicated for the termination of an unsuccessful pregnancy complicated by various factors.

In some cases, the remedy can be used at an even later date if there is a frozen pregnancy. This could be the 2nd and 3rd trimester. In this case, it is quite difficult to carry out the procedure surgically, as this may lead to fetal defects. The drug stimulates the birth process.

It is used for incomplete miscarriage, in which remains of the fetus and endometrium remain in the uterus. In this case, the product helps remove all residues.

Medical termination of pregnancy can only be performed in a specialized clinic. The use of Oxytocin requires constant monitoring by doctors. Doctors check whether the uterus is completely cleared of the fetus and its remains.

What is the optimal dosage? It is also determined by the doctor, since correct dose depends on many factors. The amount of injection administered affects the frequency of uterine contractions and the end time of contractions. The dose is calculated based on the timing and characteristics of the course of pregnancy.

Injections are made into the area of ​​the cervix adjacent to the vagina. Injections are also given in uterine wall. The product can be used nasally. When administering an injection intramuscularly, a dose of 0.5-1 IU is indicated at an hourly interval. When administering an injection into a vein, a dropper containing 10-30 drops is used. In this case, the time interval is one minute. The dose is 1-3 IU. The product is mixed with 300-500 ml of a 5% solution.

Side effects and contraindications

The product has side effects:

• Increased heart rate;
• Fluctuations in blood pressure;
• Nausea, ;
• Problems with blood circulation in the brain;
• Brain hemorrhage;
• The occurrence of spasms in the bronchi;
• Anaphylactic shock.

Oxytocin has the following contraindications:

• Jumps in blood pressure after curettage;
• Possibility of miscarriage with increased bleeding;
• Use of hormonal agents earlier than 5 hours before administration of the drug;
• Observation after curettage of dizziness, fainting, problems with orientation in space;
• Discrepancy between the size of the patient's pelvis and the size of the embryo's head;
• Transverse position of the embryo;
• Existing ruptures and damage to the uterine walls;
• The presence of scars on the uterine walls;
• Insufficiently mature state of the cervix;
• The presence of placenta previa. This contraindication is quite serious, since detachment of the child’s place may pose a threat to the patient’s life;
• Individual intolerance.

Attitudes towards oxytocin in the medical community vary. Some doctors are confident that it is better not to use this drug for medical abortion. It is more suitable as a restorative tool after the curettage procedure.

The hormone is used only in inpatient conditions. This precaution is due to the fact that when it is used, increased stimulation of smooth muscles occurs. This can cause uterine rupture and severe bleeding.

The drug Oxytocin is used in obstetrics for certain difficulties, often in the last month of pregnancy. Also, the need for injections appears when late toxicosis is detected.

Important information! The instructions, which below describe all the effects of Oxytocin injections on the human body, talk about the treatment of the disease and the use of the medicine itself, are not official and are posted solely for informational purposes, so that the patient has an idea of ​​what course of treatment awaits him before purchasing.

You should not take all the information presented below as a reason to self-medicate, because in any case, consultation and examination professional doctor won't hurt. After all, sometimes the symptoms we are used to may indicate the presence of a more serious disease or pathology that cannot be detected on our own. It is for this reason that do not ignore the advice of doctors, always follow the suggested dosages and be healthy!

Form, composition, packaging

Oxytocin is sold in almost any pharmacy in the form of a special solution for injection. It has a transparent color and not a pronounced odor. The main substance of the drug is oxytocin, and additional active ingredients are plain water, chlorobutanol and acetic acid solution.

Storage period and conditions

Store in a cool place (allowed in the refrigerator), provided that the air temperature does not fall below number four on the thermometer and does not exceed fifteen degrees above zero.

You can keep them in the house for two years, based on the release date, which can be found on the cardboard packaging or, most likely, with outside the bottom of the ampoule itself.

Pharmacology

This drug is prescribed when it is necessary to prematurely induce labor.

Pharmacokinetics

After intravenous injection, the drug begins to act immediately and decreases its effect after about an hour. When administered intramuscularly, the effect begins no later than five minutes and its duration does not exceed three hours, but the final effect depends on the personal characteristics of the body. All components of the drug are rapidly absorbed through the mucous membrane of the nasal passages.

The detected connection with proteins often does not exceed 30%. Incomplete elimination is observed within one to six minutes after exposure to the drug. In the third trimester of pregnancy and during breastfeeding, this period may become even shorter. Metabolism occurs in the liver and kidneys, due to the work of which it is excreted from the body.

Oxytocin injections indications for use

Oxytocin is used in cases where it is necessary to enhance the stimulation of labor or when artificial extraction of the fetus is necessary in case of incompatibility of the Rh factor of the mother and child, during too long pregnancy, that is, when the estimated date of birth was left behind, and contractions were not yet close.

Also, the need for injections appears when gestosis or, as it is also called, late toxicosis is detected. Due to him negative influence The mother’s body experiences a gradual deterioration in the functioning of the kidneys, some parts of the brain and blood vessels. You can understand that a future woman in labor has gestosis based on the following signs:

• periodically there is no ability to focus your gaze on anything;
• headache, which sometimes develops into migraines;
• blood pressure surges;
• by the presence of protein in the urine;
• of course, nausea and vomiting;
• At first, slight internal swelling is observed.

Oxytocin is also used due to the death of the fetus (at any stage of pregnancy), due to the breaking of waters that occurred prematurely, partial abortion, and for the preventive purposes of bleeding.

Contraindications

It should not be used if you have allergies or high blood pressure, so before prescribing in the hospital, these indicators must be checked.

It’s also worth looking for ways alternative treatment, if it became known about heart problems in the expectant mother, the uterus became very large, and an ultrasound showed a very strong difference in the size of the fetus and the pelvis of the woman in labor.

In addition, attention is always paid to the presence of scars and scars on the uterus that appeared there after certain surgical procedures, to the position of the fetus (in this situation it should not be in a transverse or oblique position), how small the woman’s pelvic area is and other similar reasons .

There is also a ban on injections if hypoxia is diagnosed in the fetus, that is oxygen starvation, hypertensive contractions of the mother's uterine passages or acute stage formation of toxins in the body.

Oxytocin instructions for use

During weak or infrequent contractions, Oxytocin injections are given intramuscularly at a maximum of 2.0 IU. If necessary, you can administer the medicinal liquid using this method every half hour to hour. If we're talking about about drip administration, then one milliliter of solution, that is, 5 IU, must be diluted in a 5% glucose solution, the amount of which should not exceed 500 milliliters. At the beginning of the procedure, no more than eight drops of the drug can enter the body within a minute, and later their number reaches forty drops in sixty seconds.

To prevent bleeding in the first twenty-four hours, administer up to 8 IU at a time and repeat this action three times in one day and for three days.

But during caesarean section After the fetus is removed, injections of 5 IU are injected into the wall of the uterus. In case of an overdose, the child may develop jaundice due to the effect of the drug on his body.

By the way, which is significant, similar injections are carried out in a similar way in veterinary practice, although the dosage there is slightly different. But the reasons for using it are actually the same, namely:

• to get rid of endometritis and mastitis;
• retention of placenta;
• carrying the baby for too long;
• uterine bleeding, which may occur shortly after childbirth;
• to try to restart the supply of breast milk.

Unlike people, animals are given injections only once, without the need for a second course. For example, dogs need to administer about 10 units - the exact amount is determined by the total weight of the animal, but for cats 2 - 3 units at a time is enough.

To ensure the effect occurs as quickly as possible, veterinarians do intravenous injection based on a glucose solution, but in this situation the initial dose must be reduced by 30%.

The drug is often used only once: dogs are given 5-10 units depending on weight, cats - 2-3 units. For a quick effect, intravenous administration of glucose solution is practiced, in which case the dose is reduced by 30%. Subsequent administration is possible, but the effect of the medicine decreases with each new injection and it is not possible to achieve the initial effect.

Oxytocin during pregnancy

The drug Oxytocin can be used not only during pregnancy, but also to terminate it at early stages. After introducing a certain dose of solution into the patient’s body, it takes a very long time short term artificial contractions begin, which provoke the premature appearance of an incompletely formed fetus.

Such methods have to be resorted to not only because of the wishes of the pregnant girl herself, but also according to the results of ultrasound and tests, which may indicate incompatibility between the fetus and the mother or about emerging pathologies.

But it is still worth noting that in medical practice Still, they prefer to use other drugs of similar action for abortions, which are designed exclusively for such situations.

In some cases, Oxytocin can be used at a later date, namely at the fourteenth week, when the fading of intrauterine life or developmental defects were discovered, in which further existence is impossible.

Abortion, which is carried out with the participation medications(and not only) must be carried out under the supervision of practicing doctors, who must monitor the entire procedure and the patient’s condition, as complications may arise or it may worsen sharply general state. In addition, only a doctor can confirm the complete exit of the fetus from the body and help cope with the bloodshed that often occurs after the end.

As for the dosage, there are no clear recommendations, in the sense that everything depends on the frequency of uterine contractions and their duration. And since all this is individual in nature, the amount of medication administered is determined for each individual separately.

But it is worth noting that patients with fibroids, abnormal developments in the uterine area and scars in the same area are strictly prohibited from being prescribed Oxytocin.

Side effects

When the drug begins to act, sometimes there is an increase in blood pressure, fatigue, itching and redness of the skin, urinary retention, an increasing feeling of nausea and subsequent vomiting. There is a risk of rupture fallopian tubes as a result of too strong labor activity, and also in the baby, neonatal jaundice may appear almost immediately after birth.

Overdose

Hyperstimulation of the uterus occurs, resulting in uterine rupture and bleeding. As for the child, postpartum injuries may be detected.

If negative manifestations are detected, the drug is administered and stopped immediately and diuretics are prescribed and other necessary methods treatment.

Drug interactions

Oxytocin provokes vasoconstriction when exposed to sympathomimetics. It can be taken with caution and under the supervision of doctors with Ftorotan and Cyclopropane, as they increase the risk of arterial hypotension. Concomitant use with MAO inhibitors can lead to the same result. And when using inhalation drugs for anesthesia, it leads to a weakening of its effect on the uterus.

Additional instructions

Never take for self-medication or for performing a home abortion. Such a decision can significantly affect the girl’s health and even lead to death.

Oxytocin analogues

The most common drug substitutes are:

• Oxytocin-Grindeks;
• Oxytocin-Ferein;
• Oxytocin-Vial;
• Oxytocin-Richter;
• Syntocinon;
• Pitocin;
• Oxytocin-MEZ.

Oxytocin price

The last recorded price within Russia is 70 rubles. But it may vary depending on the city, region or pharmacy where the purchase is made.

Oxytocin injections reviews

Here is what one of the patients says, who personally experienced the effects of Oxytocin: “During the first birth, the cervix did not open and the contractions were very weak. Therefore, doctors had to resort to additional help, in the form of injections. After this, the contractions began to be very strong, but the cervix did not open, and the baby turned out to be very large for my build. Therefore, the birth was very difficult and I still cannot get rid of the consequences of the Oxytocin injection.

It was prescribed to me to restore the uterus, since it could not independently return to its original state and begin to function normally again. And it was after this treatment course that I felt, or rather saw, really good result. Due to the effect of the drug, my uterus completely returned to normal in a very short time, muscle tone increased, it stopped falling out, screwed into place well and no longer occurred. discomfort and problems with it in general.

The drug Oxytocin is a means of increasing myometrial tone and contractile activity of the uterus. Due to these properties, this drug is widely used to stimulate labor, for example, when uterine contractions become too weak. We will find out in what other cases Oxytocin tablets are used and how to take this medicine correctly by reading this article.

Composition of the drug

For the most part, Oxytocin is produced as a solution for intramuscular as well as intravenous administration. 1 ml of such a solution contains 5 IU of the active substance of the same name. However, this drug is also available in tablet form.

pharmachologic effect

It should be noted that oxytocin is a synthetic analogue female hormone, interacting with receptors of the uterine myometrium. This hormone is produced in the pituitary gland and acts on smooth muscles, thereby causing uterine contractions. Under the influence of Oxytocin, the excitability of the membranes increases, the blood supply to the uterus improves, which means contractions appear that are no different from ordinary spontaneous contractions. Besides, active substance This medicine stimulates the smooth muscles in the area of ​​the milk ducts, thereby activating the secretion of milk during lactation.

Indications for use

The most commonly described remedy is used in cases of post-term pregnancy, after a period of 42 weeks. Oxytocin can also be prescribed in late pregnancy, when it is important to induce labor due to the development of gestosis. Primary or secondary weakness of labor also implies the introduction of this medication. In addition, Oxytocin can be used for such pathological conditions, such as Rh conflict, discharge of amniotic fluid, internal death of the fetus, or intrauterine developmental delay. True, in all these cases this drug is used in the form of a solution. Doctors often prescribe oxytocin tablets to improve uterine contractions after childbirth or after an abortion, which helps prevent bleeding from the uterus.

Oxytocin during abortion

Many girls and women are interested in whether the drug Oxytocin is used to terminate pregnancy? Gynecologists respond to this that this drug is not used for these purposes; for this, specialists choose other medications, for example, Misoprostol or Mifepristone. Oxytocin shows its effectiveness only from the 14th week of pregnancy, and it can be prescribed for abortion only after medications that prepare the cervix for dilatation.

Dosage of the drug

To stimulate labor standard dose Oxytocin is a 5 mIU medication. In the postpartum period, this medication is administered at a dose of 5 mIU immediately after separation of the placenta. In case of incomplete or failed abortion, the medicine is administered intravenously, for which 10 IU/ml of this drug is added to saline solution. Oxytocin tablets are taken one tablet twice a day.

Contraindications of the drug

It is worth noting that the drug Oxytocin is contraindicated in case of partial or complete placenta previa, arterial hypertension, heart disease, impaired renal function, fetal compression, excessive stretching of the uterus, as well as emergency cases that require surgical intervention. This drug is not prescribed for hypersensitivity to the active substance.

Side effects

Oxytocin - enough powerful tool, which may cause some side effects, such as hypertension or even uterine rupture. In some cases, this remedy may increase bleeding. The immune system when taking medications may cause bronchospasm, as well as some allergic reactions up to anaphylactic shock. That is why it is prohibited to prescribe this drug on your own. Good health to you!