Novocain - description. Novocaine (instructions for use in ampoules) - solution for local anesthesia

Self-medication can be harmful to your health.
You should consult your doctor and read the instructions before use.

Novocaine injections (in ampoules): instructions for use

Compound

1 ml of solution contains: active substance- procaine 0.005 or 0.02 g;

Excipients: hydrochloric acid solution 0.1 M - up to pH 3.8 - 4.5, water for injection - up to 1 ml.

Description

Transparent, colorless or slightly yellowish liquid.

pharmachologic effect

Pharmacotherapeutic group:

drugs for local anesthesia- esters of para-aminobenzoic acid.

ATX code - N01BA02.

Indications for use

Infiltration, conduction, epidural and spinal anesthesia, intraosseous anesthesia, anesthesia of the mucous membranes (in ENT practice); vagosympathetic and paranephric blockade. Circular and paravertebral blockades for eczema, neurodermatitis, ischalgia.

To potentiate the action of basic anesthetics; for the relief of pain of various origins.

As an adjuvant for certain diseases that are more common in old age, incl. endarteritis, atherosclerosis, arterial hypertension, spasms of coronary and cerebral vessels, joint diseases of rheumatic and infectious origin. To dissolve penicillin in order to extend its duration of action.

Contraindications

Hypersensitivity to procaine.

Directions for use and doses

Individual, depending on the type of anesthesia, route of administration, indications.

For infiltration anesthesia 350 - 600 mg - 0.5% solution;

for conduction anesthesia - 2% solution (up to 25 ml);

for epidural - 2% solution (20-25ml).

To reduce absorption and prolong the effect of local anesthesia, an additional 0.1% solution of epinephride hydrochloride is administered - 1 drop per 2-5-10 ml of procaine solution.

With perinephric blockade (according to A.V. Vishnevsky), 50 - 80 ml of a 0.5% solution is injected into the perinephric tissue.

Higher doses for infiltration anesthesia for adults: the first single dose at the beginning of the operation is not higher than 0.75 g of a 0.5% solution (150 ml). In the future, for every hour - no more than 2 g (400 ml of 0.5% solution).

The maximum dose for use in children is up to 15 mg/kg.

To eliminate pain, inject intramuscularly or intravenously slowly 1 - 15 ml of a 0.5% solution 2-3 times a day.

In the treatment of endarteritis, atherosclerosis, arterial hypertension, spasms coronary vessels and cerebral vessels, joint diseases of rheumatic and infectious origin in elderly patients, a 2% solution of novocaine 5 ml is injected into the muscles 3 times a week; for a course of 12 injections.

If necessary, 4 courses can be conducted during the year. Treatment is carried out in a hospital setting.

Side effect

Arterial hypotension, collapse, dizziness, weakness, urticaria, allergic reactions, anaphylactic shock.

Overdose

Symptoms: pallor of the skin and mucous membranes, dizziness, nausea, vomiting, “cold” sweat, increased breathing, tachycardia, decreased blood pressure, up to collapse, apnea, methemoglobinemia. Action on the central nervous system manifested by a feeling of fear, hallucinations, convulsions, and motor agitation.

Treatment: maintaining adequate pulmonary ventilation with oxygen inhalation, intravenous administration of short-acting medications for general anesthesia, in severe cases - detoxification and symptomatic therapy.

Interaction with other drugs

When administered intravenously, it enhances the inhibitory effect on the central nervous system of drugs for general anesthesia, hypnotics, sedatives, narcotic analgesics and tranquilizers.

Procaine metabolite para-aminobenzoic acid is a competitive antagonist of sulfonamides and can weaken them antimicrobial effect.

Pharmacodynamics. Local anesthetic with moderate anesthetic activity and wide range therapeutic action. Reduces the formation of acetylcholine and the release of norepinephrine (presynaptic effect), blocks autonomic nodes, reduces spasm of smooth muscles internal organs, suppresses gland secretion digestive tract, dilates blood vessels, which leads to a decrease in blood pressure, myocardial excitability (antiarrhythmic effect) and nerve cells brain. Procaine suppresses visceral reflexes and somatic polysynaptic spinal reflexes.
Pharmacokinetics. When administered parenterally, it is well absorbed. It is rapidly hydrolyzed in the blood plasma through the influence of plasma esterases and cholinesterases. The products of enzymatic hydrolysis are para-aminobenzoic acid and diethylaminoethanol. 80% of the drug is excreted in the urine. Very short action The drug is due to its pronounced vasoconstrictor effect and high pKa.

Indications for use of the drug Novocain

Infiltration anesthesia for surgical interventions, for perinephric blockade and other therapeutic blockades.

Use of the drug Novocain

For local anesthesia, the dose of the drug depends on the nature surgical intervention.
For infiltration anesthesia maximum dose the drug is 150 ml at the beginning of the operation, then, during each hour of the operation - no more than 400 ml of the drug.
For perinephric blockade, 50-80 ml of the drug is injected into the perinephric tissue.
For circular and paravertebral blockade, subcutaneous injection is used.
To eliminate pain, the drug is administered intramuscularly.

Contraindications to the use of the drug Novocain

Hypersensitivity to the drug, myasthenia gravis.

Side effects of the drug Novocain

dizziness, general weakness, hypotension, collapse, allergic reactions. Possible development anaphylactic shock.

Special instructions for the use of the drug Novocain

Before use, it is necessary to conduct tests to determine individual sensitivity to the drug. It should be taken into account that when local anesthesia is administered in the same total dose, the toxicity of procaine increases with increasing concentration of the solution used. Novocaine penetrates slowly through intact mucous membranes, so it is ineffective for superficial anesthesia. Use with caution in severe diseases of the heart, liver and kidneys.
During pregnancy and lactation, the drug can be used only if the expected benefit to the mother outweighs the risk to the fetus and newborn.

Interactions of the drug Novocain

The drug counteracts the improvement in neuromuscular transmission that anticholinesterase drugs cause. With intravenous administration of Novocaine, the muscle relaxant effect of ditilin is enhanced. General Application procaine and novocainamide leads to an increase in the severity of the effects of the latter. Cross-sensitization is also possible. Novocaine reduces the effectiveness of antimicrobial sulfonamide drugs.

Novocaine overdose, symptoms and treatment

An overdose of novocaine causes motor agitation, collapse, nausea, vomiting, convulsions, and respiratory depression. In the postoperative period, secondary hyperemia and bleeding are possible as a result of the use of adrenergic agonists in combination with local anesthetics. In patients, as well as in medical personnel Possible allergy to Novocaine.
Treatment. In case of overdose use artificial respiration, inhalation of carbogen, in case of convulsions, short-acting barbiturates are administered intravenously, in case of collapse - intravenous drip blood replacement fluids, in case of cardiac dysfunction - appropriate resuscitation measures.

Novocaine- This is a local anesthetic. His international name coincides with the name of its active substance - Procaine.

Dosage form:

Injection;

Ointment for external use;

Rectal suppositories.

Pharmacological action of novocaine

Novocaine It has a local anesthetic effect, has a broad therapeutic effect and moderate anesthetic activity. Procaine is a weak base that blocks Na+ channels and prevents the generation of impulses in nerve endings and the conduction of impulses along nerve fibers. Novocaine also changes the potential in the membranes of nerve cells without significantly affecting the resting potential.

Novocaine suppresses not only pain impulses, but also impulses of other modalities. When absorbed or introduced into the bloodstream, it reduces the excitability of the peripheral cholinergic system, eliminates spasms of smooth muscles, has a ganglion-blocking effect, and reduces the excitability of the motor zones of the cerebral cortex and myocardium.

When administered intravenously, it can provide hypotensive, antishock and antiarrhythmic effect. Eliminates polysynaptic reflexes and descending inhibitory influences of the brain stem. Also more effective for functional disorders of the central nervous system on early stages in older people.

Indications for use of novocaine

Spinal, epidural, conduction and infiltration anesthesia;

Superficial anesthesia;

Vagosympathetic perinephric or cervical blockade;

Regional anesthesia;

Anal fissures;

Haemorrhoids;

Previously used for stomach and skin problems.

Contraindications to the use of novocaine

Hypersensitivity, including to local anesthetic ethers;

During anesthesia using the creeping infiltrate method - fibrotic changes in fabric;

With subarachnoid anesthesia - arterial hypotension, bleeding, AV block, shock, septicemia.

Novocaine should be used with caution when:

Acute blood loss;

Decreased hepatic blood flow;

Progression of cardiovascular failure;

Inflammation or infection of the site where the injection is needed;

Age up to 18 years or after 65 years;

Kidney failure;

Serious illnesses;

Weakening of the body;

Pregnancy or childbirth.

Possible side effects

From the nervous system:

Headache;

Drowsiness;

Dizziness;

Weakness;

Loss of consciousness;

Motor restlessness;

• Convulsions;

  Hearing and vision impairment;

  Cauda equina syndrome (paresthesia, leg paralysis);

• Paralysis of the respiratory muscles;

  Respiratory paralysis;

  Sensory and motor block.

From the cardiovascular system:

Decreased or increased blood pressure;

• Peripheral vasodilation;

  Badicardia;

  Chest pain;

From the urinary system:

Involuntary urination.

From the outside digestive system:

• Involuntary defecation.

From the blood side:

Methemoglobinemia.

Allergic reactions:

Skin rash;

Itchy skin;

Anaphylactic reactions, including anaphylactic shock;

Urticaria, both on the mucous membranes and on the skin.

For anesthesia in dentistry:

Paresthesia and numbness of the tongue and lips;

Prolongation of anesthesia

Others side effects:

Persistent anesthesia;

Return of pain;

Impotence;

Hypothermia

Overdose symptoms

Pallor of mucous membranes and skin;

• Dizziness;

  Cold sweat;

  Tachycardia;

  Increased breathing;

  Reduced blood pressure;

• Methemoglobinemia;

  Feeling of fear;

  Convulsions;

  Hallucinations;

  Motor excitement.

To get rid of the symptoms of overdose, adequate pulmonary ventilation should be maintained with inhaled oxygen, as well as intravenous administration of short-acting drugs for general anesthesia.

Method of application and dosage of novocaine

For infiltration anesthesia - 350-600 milligrams of 0.25%-0.5% solution;

For tight creeping infiltration (anesthesia according to the Vishnevsky method) - 0.125% -0.25% solutions;

For conduction anesthesia - 1-2% solutions up to 25 milliliters;

For epidural anesthesia – 20-25 milliliters of a 2% solution;

For spinal anesthesia- 2-3 milliliters of 5% solution;

For terminal anesthesia used in otorhinolaryngology - a 10-20% solution.

Interaction with other drugs

At simultaneous administration with other drugs it increases negative impact on the central nervous system;

When taken with anticoagulants, the risk of bleeding increases;

If you treat the injection site with a disinfectant solution containing heavy metals, there is a high probability of swelling or pain;

When using epidural and spinal anesthesia together with trimetaphane, mecamylamine, guanethidine and guanadrel, the risk of bradycardia and low blood pressure increases;

Use with MAO inhibitors increases the risk of hypotension;

Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. There are contraindications, consultation with a specialist is required.

In this article you can read the instructions for use of the drug Novocaine. Feedback from site visitors - consumers - is presented of this medicine, as well as the opinions of specialist doctors on the use of Novocaine in their practice. We kindly ask you to actively add your reviews about the drug: whether the medicine helped or did not help get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Novocaine in the presence of existing structural analogues. Use for anesthesia, blockades and dilution of drugs in adults, children, as well as during pregnancy and lactation.

Novocaine- a local anesthetic with moderate anesthetic activity and a wide range of therapeutic effects. Being a weak base, it blocks Na+ channels, preventing the generation of impulses in the endings of sensory nerves and the conduction of impulses along nerve fibers. Changes the action potential in the membranes of nerve cells without a pronounced effect on the resting potential.

Suppresses the conduction of not only pain, but also impulses of other modalities. When absorbed and directly vascularly introduced into the bloodstream, it reduces the excitability of peripheral cholinergic systems, reduces the formation and release of acetylcholine from preganglionic endings (has some ganglion-blocking effect), eliminates spasm of smooth muscles, reduces the excitability of the myocardium and motor zones of the cerebral cortex.

Eliminates descending inhibitory influences of the reticular formation of the brain stem. Inhibits polysynaptic reflexes. In large doses, it can cause convulsions. It has a short anesthetic activity (the duration of infiltration anesthesia is 0.5-1 hour).

Pharmacokinetics

Subject to complete systemic absorption. The extent of absorption depends on the site and route of administration (especially vascularization and blood flow rate of administration) and the final dose (amount and concentration). It is quickly hydrolyzed by plasma and liver esterases to form two main pharmacologically active metabolites: diethylaminoethanol (has a moderate vasodilator effect) and para-aminobenzoic acid (is a competitive antagonist of sulfonamide drugs and can weaken their antimicrobial effect). It is excreted primarily by the kidneys in the form of metabolites; no more than 2% are excreted unchanged.

Indications

• infiltration (including intraosseous) anesthesia;
• for diluting medications and reducing the pain effect of administered medications;
• vagosympathetic cervical, perinephric, circular and paravertebral blockades.

Release forms

Solution for injection (injections in ampoules) 0.25%, 0.5% and 2%.

Rectal suppositories 100 mg.

Instructions for use and dosage

Only for procaine solution (active ingredient of the drug Novocaine) 5 mg/ml (0.5%).

For infiltration anesthesia, 350-600 mg (70-120 ml) is administered. Higher doses for infiltration anesthesia for adults: the first single dose at the beginning of the operation - no more than 0.75 g (150 ml), then during each hour of the operation - no more than 2 g (400 ml) of solution.

With perinephric blockade (according to Vishnevsky), 50-80 ml are injected into the perinephric tissue.

For circular and paravertebral blockade, 5-10 ml is administered intradermally. For vagosympathetic blockade, 30-40 ml is administered.

To reduce absorption and prolong the effect of local anesthesia, an additional 0.1% solution of epinephrine hydrochloride is administered - 1 drop per 2-5-10 ml of procaine solution.

The maximum dose for use in children over 12 years of age is 15 mg/kg.

Side effect

• headache;
• dizziness;
• drowsiness;
• weakness;
• increase or decrease in blood pressure;
• peripheral vasodilation;
• collapse;
• bradycardia;
• arrhythmias;
• chest pain;
• itchy skin;
• skin rash;
• other anaphylactic reactions(including anaphylactic shock);
• urticaria (on the skin and mucous membranes).

Contraindications

• hypersensitivity (including to para-aminobenzoic acid and other local anesthetic esters);
• for anesthesia using the creeping infiltrate method - pronounced fibrous changes in the tissues.

Use during pregnancy and breastfeeding

If it is necessary to prescribe the drug during pregnancy, the expected benefit to the mother should be compared with the potential risk to the fetus. With caution during childbirth.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

special instructions

Patients require monitoring of functions of cardio-vascular system, respiratory system and the central nervous system.

Monoamine oxidase inhibitors should be discontinued 10 days before local anesthetic administration.

It should be borne in mind that when performing local anesthesia using the same total dose, the toxicity of procaine is higher, the more concentrated the solution is used.

Effect on ability to drive vehicles and mechanisms

During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous species activities requiring increased concentration attention and speed of psychomotor reactions.

Drug interactions

Strengthens the inhibitory effect on the central nervous system of drugs for general anesthesia, sleeping pills, sedatives, narcotic analgesics and tranquilizers.

Anticoagulants (ardeparin sodium, dalteparin sodium, danaparoid sodium, enoxaparin sodium, heparin sodium, warfarin) increase the risk of bleeding. When treating the injection site with disinfectant solutions containing heavy metals, the risk of developing local reaction in the form of pain and swelling.

Use with monoamine oxidase inhibitors (furazolidone, procarbazine, selegiline) increases the risk of developing a pronounced decrease in blood pressure. Strengthens and prolongs the effect of muscle relaxants. Vasoconstrictors (epinephrine, methoxamine, phenylephrine) prolong the local anesthetic effect.

Novocaine reduces the antimyasthenic effect of drugs, especially when used in high doses, which requires additional correction of the treatment of myasthenia gravis.

Cholinesterase inhibitors (antimyasthenic medicines, cyclophosphamide, demecaria bromide, ecothiopathy iodide, thiotepa) reduce the metabolism of local anesthetic drugs.

The metabolite of procaine (para-aminobenzoic acid) is an antagonist of sulfonamides.

Analogues of the drug Novocain

Structural analogues according to active substance:

• Novocaine Bufus;
• Novocain-Vial;
• Novocaine base;
• Novocaine solution for injection;
• Procaine hydrochloride.

If there are no analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and look at the available analogues for the therapeutic effect.

NOVOCAINE Novocaine

Active substance

›› Procaine*

Latin name

Pharmacological group: Local anesthetics

Nosological classification (ICD-10)

Composition and release form

1 ml of solution for injection contains procaine hydrochloride 5 mg; in ampoules of 5 ml, in a cardboard box 10 pcs.

pharmachologic effect

pharmachologic effect- local anesthetic. Blocks the occurrence of an impulse and its conduction through nerve fiber- especially afferent.

Indications

Infiltration, conduction, epidural and spinal anesthesia; vagosympathetic and perinephric blockade; pain syndrome at peptic ulcer stomach and duodenum, hemorrhoids, nausea.

Contraindications

Hypersensitivity.

Side effects

Dizziness, weakness, hypotension, allergic reactions.

Directions for use and doses

IM - 5-10 ml of 1-2% solution 3 times a week for a month, after which a 10-day break is taken; For infiltration anesthesia, 0.25-0.5% solutions are used, for conduction anesthesia - 2% solution.
Inside - 1/2 teaspoon (for pain).

Best before date

Storage conditions

List B.: In a place protected from light, at a temperature not exceeding 30 °C.

* * *

NOVOCAINE (Novocainum). b -Diethylaminoethyl ester of para-aminobenzoic acid hydrochloride. Synonyms: Aethocain, Allocaine, Ambocain, Aminocaine, Anesthocaine, Atoxicain, Cerocain, Chemocain, Citocain, Ethocaine, Genocaine, Herocaine, Isocain, Jenacain, Marecaine, Minocain, Naucain, Neocaine, Pancain, Paracaine, Planocaine, Polocainum, Procaine, Procaini hydrochlor idum , Procaine hydrochloride, Protocaine, Sevicaine, Syncaine, Syntocain, Topocaine, etc. Colorless crystals or odorless white crystalline powder. Very easily soluble in water (1:1), easily soluble in alcohol (1:8). Aqueous solutions sterilize at + 100 C for 30 minutes. Solutions of novocaine are easily hydrolyzed into alkaline environment. To stabilize, add O.1N. hydrochloric acid solution to pH 3.8 - 4.5. Novocaine was synthesized in 1905. Long time it was the main local anesthetic used in surgical practice. Compared to modern local anesthetics (lidocaine, bupivacaine, etc.), it has less strong anesthetic activity. However, due to the relatively low toxicity, large therapeutic breadth and additional valuable pharmacological properties allowing its use in various fields of medicine, it still has wide application. Unlike cocaine, novocaine does not cause addiction. In addition to the local anesthetic effect, novocaine, when absorbed and directly introduced into the bloodstream, has a general effect on the body: it reduces the formation of acetylcholine and reduces the excitability of peripheral cholinoreactive systems, has a blocking effect on the autonomic ganglia, reduces spasms of smooth muscles, reduces the excitability of the heart muscle and motor areas of the cerebral cortex. brain In the body, novocaine is hydrolyzed relatively quickly, forming para-aminobenzoic acid and diethylaminoethanol. Novocaine breakdown products - pharmacologically active substances. para-Aminobenzoic acid (vitamin H 1) is integral part molecules folic acid; it is also included in a bound state in other compounds found in plant and animal tissues. For bacteria, para-aminobenzoic acid is a “growth factor”. By chemical structure it is similar to part of the sulfonamide molecule; entering into a competitive relationship with the latter, para-aminobenzoic acid weakens them antibacterial effect(cm. Sulfonamide drugs). Novocaine, as a derivative of para-aminobenzoic acid, also has an antisulfonamide effect. Diethylaminoethanol has moderate vasodilatory properties. Novocaine is widely used for local anesthesia - mainly for infiltration; It is of little use for superficial anesthesia, since it slowly penetrates through intact mucous membranes. Novocaine is also widely prescribed for therapeutic blockades. For infiltration anesthesin, 0.25 - 0.5% solutions are used; for anesthesia according to the A.V. method Vishnevsky (tight creeping infiltration) 0.125 - 0.25% solutions; for conduction anesthesia - 1 - 2% solutions; for epidural - 2% solution (20-25 ml). Sometimes novocaine is also prescribed for intraosseous anesthesia. For anesthesia of mucous membranes, novocaine is sometimes used in otorhinolaryngology. To obtain a superficial anesthetic effect, 10 - 20% solutions are required. With local anesthesia, the concentration of novocaine solutions and their quantity depend on the nature of the surgical intervention; method of administration, condition and age of the patient, etc. It should be borne in mind that with the same total dose of the drug, the more concentrated the solution used, the higher the toxicity. To reduce absorption and prolong the effect of novocaine solutions during local anesthesia, a solution of adrenaline hydrochloride (0.1%) is usually added to them - 1 drop per 2 - 5 - 10 ml of novocaine solution, since novocaine, unlike cocaine, does not cause vasoconstriction. Novocaine is also recommended for the treatment various diseases. Novocaine blockade aims to weaken the reflex reactions that occur during the development pathological processes. For perinephric blockade (according to A.V. Vishnevsky), 50 - 80 ml of a 0.5% solution or 1OO - 150 ml of a 0.25% solution of novocaine is injected into the perirenal tissue, and for vagosympathetic blockade - 30 - 100 ml of 0.25% solution. Novocaine solutions are also used intravenously and orally (for hypertension, late toxicosis of pregnant women with hypertensive syndrome, spasms blood vessels, phantom pain, gastric and duodenal ulcers, nonspecific ulcerative colitis, itching, neurodermatitis, eczema, keratitis, iridocyclitis, glaucoma, etc.). From 1 to 10 - 15 ml of a 0.25 - 0.5% solution is injected into a vein. Inject slowly, preferably isotonic solution sodium chloride. The number of injections (sometimes up to 10 - 20) depends on the severity of the disease and the effectiveness of treatment. To relieve spasms of peripheral vessels and improve microcirculation during frostbite (in the pre-reactive period), a mixture consisting of 10 ml of 0.25% novocaine solution, 2 ml of 2% papaverine solution, 2 ml of 1% solution has been proposed nicotinic acid and 10,000 units of heparin. Injected intra-arterially. Intravenous administration a small amount of novocaine potentiates the effect of drugs used for anesthesia, has an analgesic and anti-shock effect, and therefore it is sometimes used to prepare for anesthesia, during anesthesia (to enhance the effect of the main anesthetic) and in postoperative period(to relieve pain and spasms). Take 0.25 - 0.5% solution up to 30 - 50 ml orally 2 - 3 times a day. Intradermal injections of 0.25 - 0.5% solution are recommended for circular and paravertebral blockade for eczema, neurodermatitis, sciatica, etc. Suppositories (rectal) with novocaine are used as a local anesthetic and antispasmodic for spasms of intestinal smooth muscles. Novocaine (5 - 10% solution) is also used using the electrophoresis method. Due to the ability of the drug to reduce the excitability of the heart muscle, it is sometimes prescribed for atrial fibrillation- inject a 0.25% solution into a vein, 2 - 5 ml up to 4 - 5 times. More effective and specifically acting antiarrhythmic drugs are local anesthetics lidocaine and trimecaine and novocaine derivative - novocainamide (see). Novocaine is used to dissolve penicillin in order to extend its duration of action (see Penicillin group drugs). Novocaine is also prescribed in the form intramuscular injections for some diseases that are more common in old age (endarteritis, atherosclerosis, hypertonic disease, spasms of coronary and cerebral vessels, diseases of the joints of rheumatic and infectious origin and etc.). Treatment is carried out in a hospital setting. A 2% solution of novocaine, 5 ml, is injected into the muscles 3 times a week; There are 12 injections per course, after which a 10-day break is taken. During the year, the course of treatment is repeated up to 4 times. The effect is observed mainly in the early stages of diseases associated with functional disorders CNS. Novocaine is usually well tolerated, but it can cause side effects and should be used with caution with all routes of administration. Some patients experience increased sensitivity to the drug (dizziness, general weakness, decreased blood pressure, collapse, shock). Allergic reactions may develop skin reactions(dermatitis, peeling, etc.). To identify hypersensitivity Novocaine is initially prescribed in reduced doses. First, 2 ml of a 2% solution is injected intramuscularly, after 3 days in the absence side effects- 3 ml of this solution and only then proceed to the administration of the full dose - 5 ml per injection. Higher doses of novocaine (for adults): single dose when taken orally 0.25 g, when administered into muscles (2% solution) - 0.1 g (5 ml), when administered into a vein (0 .25% solution) - 0.05 g (20 ml); daily intake 0.75 g; when administered into the muscles (2% solution) and into the vein (0.25% solution) - 0.1 g. For infiltration anesthesia, the following highest doses are established (for adults): the first single dose at the beginning operations - no more than 1.25 g of 0.25% solution (i.e. 500 ml) and 0.75 g of 0.5% solution (i.e. 150 ml). Subsequently, during each hour of surgery - no more than 2.5 g of 0.25% solution (i.e. 1000 ml) and 2 g of 0.5% solution (i.e. 400 ml). Release forms: powder; 0.25% and 0.5% solutions in ampoules of 1; 2; 5; 10 and 20 ml and 1% and 2% solutions, 1; 2; 5 and 10 ml; 0.25% and 0.5% sterile solutions novocaine in bottles of 200 and 400 ml; 5% and 10% ointment; suppositories containing 0.1 g of novocaine. Novocain is included in the composition complex drug"Menovazin" (see). Storage: List B. In well-closed orange glass jars; ampoules and suppositories - in a place protected from light. Rp:. Sol. Novocaini 0.25% 200 ml D.S. For infiltration anesthesia Rp.: Sol. Novocaini 1% 10 ml D.t.d. N. 5 in ampull. S. For conduction anesthesia Rp.: Novocaini 1.25 Natrii chloridi 3.0 Kalii chloridi 0.038 Calcii chloridi 0.062 Aq. pro injection. 500 ml M. Steril.! D.S. For anesthesia according to the method of A.V. Vishnevsky Rp.: Novocaini 0.5 Aq. destill. 200 ml M.D.S. Inside, 1 tablespoon Rp.: Sol. Novocaini 2% 5 ml D.t.d. N. 6 in ampull. S. 5 ml into muscles 1 time every 2 days

Dictionary of medicines. 2005 .

Ozhegov's explanatory dictionary Wikipedia

novocaine- NOVOCAINE, a, m Medicine is a synthetic substitute for cocaine; is used for local anesthesia and treatment. Before the operation, the patient was administered novocaine... Explanatory dictionary of Russian nouns

Medicine from the group of painkillers; para-aminobenzoic acid diethylaminoethyl ester hydrochloride. N.'s solutions are used for local anesthesia (See Anesthesia), novocaine blockade (See Novocaine blockade), and... ... Great Soviet Encyclopedia

M. A drug used as an anesthetic. Ephraim's explanatory dictionary. T. F. Efremova. 2000... Modern Dictionary Russian language Efremova