Nystatin instructions for use for children suspension. International non-proprietary name

Nystatin is an “old” antifungal antibiotic, which represents a group of polyenes (the so-called polyenes) on pharmacy shelves. natural antibiotics). The drug has a very narrow specialization, showing its antimycotic activity against only yeast-like fungi of the genus Candida. This happens as follows: nystatin interacts with the sterols that make up the cell membranes of fungi. As a result, the permeability of cell membranes is disturbed, which entails the release of the main components of the fungus cell “free”. The action of nystatin is characterized as fungistatic, i.e. inhibiting the growth and reproduction of fungi. After removal of the fungistatic agent, their growth has every chance to resume.

Nystatin is produced immediately in four dosage forms: these are tablets, ointment, rectal and vaginal suppositories. When taken orally, the drug is poorly absorbed from gastrointestinal tract. Local application of nystatin avoids its absorption into the systemic circulation. In the body, the drug does not accumulate and is excreted in the feces. Indications for the use of the drug will vary depending on the form of release. So, vaginal and rectal suppositories are used according to the injection site, that is, in the first case it will be vaginal candidiasis, and in the second - candidiasis lower divisions intestines. Tablets are used for candidiasis of the skin and mucous membranes, as well as internal organs, ointment - only skin and mucous membranes. For prophylactic purposes, nystatin can be used in all forms of release. It should be noted that at present, this drug, in the language of Internet memes, is “no longer a cake” and is gradually losing ground in relation to a number of diseases.

So, for decades, nystatin was practically the only drug for the treatment of oral candidiasis. However, previously collected data on 90% efficiency this drug in modern realities do not find their confirmation, and in clinical practice fluconazole has proven to be much more successful in the treatment of this disease.

When Candida affects the internal organs, nystatin is administered orally, regardless of the diet. Adults should take 500,000 IU 4-8 times a day. With generalized candidiasis (when the fungal infection becomes impressive), the daily dose of nystatin can reach up to 6,000,000 IU. Doses of the drug used in pediatric practice, depend on the age of the child: 250,000 IU 3-4 times a day (from 1 to 3 years), 250,000-500,000 IU 4 times a day (over 3 years). The duration of treatment is on average 10-14 days with the possibility of repeating the drug course after a week's "rest" from antimycotic therapy. The ointment should be applied to candida-affected areas of the skin and mucous membranes. thin layer 2 times a day for 7-10 days. A combination of ointment and nystatin tablets is allowed. Before the introduction of vaginal suppositories into the vagina, the necessary hygiene procedures. Dosage regimen - 1 suppository twice a day in the morning and evening. The course of treatment is 10-14 days. Multiplicity and dosing regimen rectal suppositories similar, only the route of administration is different.

Pharmacology

Antifungal agent, antibiotic of the polyene group. By binding to sterols in the cell membrane of fungi, it disrupts its permeability, which leads to the release of the main components of the cell. Active against Candida albicans.

Pharmacokinetics

After oral administration, it is poorly absorbed from the gastrointestinal tract. It is excreted almost completely with feces unchanged. Does not accumulate.

With external and topical application not absorbed through the skin or mucous membranes.

Release form

10 pieces. - cellular contour packings (2) - packs of cardboard.

Dosage

Inside adults - 500,000-1,000,000 IU 3-4 times / day, children - 100,000 4 times / day. The duration of treatment averages 14 days.

Outwardly, intravaginally and rectally apply 2 times / day in the morning and evening.

Interaction

With the simultaneous use of nystatin with clotrimazole, the activity of the latter decreases.

Side effects

From the side digestive system: nausea, vomiting, diarrhea.

Allergic reactions: skin rash, urticaria.

Local reactions: irritation.

There may be a risk of the spread of resistant forms of fungi, which requires the abolition of nystatin.

Indications

Candidiasis of the skin, mucous membranes, oral cavity and pharynx, vagina and internal organs (gastrointestinal tract, lungs, kidneys). Prevention of fungal complications of antimicrobial therapy.

Contraindications

liver failure, pancreatitis, peptic ulcer stomach and duodenum hypersensitivity to nystatin.

Application features

Use during pregnancy and lactation

Although nystatin is absorbed in small amounts, it is not known whether it is excreted from breast milk therefore, if necessary, use during lactation should decide on the termination of breastfeeding.

Application for violations of liver function

special instructions

With the development of local irritation or an allergic reaction, nystatin should be discontinued.

During menstruation, treatment should not be interrupted.

Polyene antibiotic, which has been on the pharmacological market for decades, used as a fungistatic agent for the treatment of various forms of candidiasis, Nystatin is available in several dosage forms, including Nystatin tablets. What helps the drug in tablet form, which is used somewhat less common ointments and suppositories, you can find out by carefully studying the instructions for use or consulting with the doctor who made such an appointment. Although due to the effectiveness of the drug and its relevance, many people know the name Nystatin, what its dosage forms are used for, what therapeutic effects can be achieved with its help.

Each of those who turned to the drug can name a specific case of treatment, and this may be vaginal candidiasis, thrush or Nystatin for stomatitis, recommended by the dentist. This fungistatic has undeniable advantages in the form of low toxicity, undeniable effectiveness and democratic price, which determined its still reliable position among antimycotic agents.

Nystatin - polyene antibiotic, a well-known fungistatic agent that is used primarily for the treatment of candidiasis, regardless of their location. Therefore, its focus is considered to be rather narrow, and usually all dosage forms of the drug are referred to as narrow therapeutic agents. It was believed that the activity of the polyene extends only to the suppression of the activity of certain species of fungi of the genus Candida, but over time it was found that it was also able to suppress the viability of the intestinal amoeba, pathogenic agent intestinal dysentery. Previously, Nystatin was used as a solution for injection, which led to its accumulation in the body and gave a number of negative consequences.

Over the past decades, it has been used in tablet form, in the form of ointments and suppositories, which gives a narrow and local effect at the site of the pathology, excluding the possibility of negative side effects. Tablets dissolve perfectly in the stomach and intestines, but are practically not absorbed into the walls, therefore, different dosage in adults and children.

As an antimycotic and fungistatic agent, Nystatin - tablets for thrush, candidiasis and some types of their manifestations, is used to treat lesions in the vagina, mouth, in the near-anal and anal area with part of the intestine, area, in the form skin lesions, on any part of the mucosa or epidermis. The indisputable advantage of the tablet form is its non-distribution into the bloodstream, and almost complete elimination from the body unchanged.

Nystatin tablets: what helps

narrow therapeutic effect drug, the length of the proven track record and the resistance that some fungi have developed to the polyene antibiotic does not mean that Nystatin has been discontinued for this reason. Indications for the use of the drug apply to fungal infections, regardless of their location on the skin and mucous membranes, but it should not be used to treat viral and bacterial lesions, because viruses and bacteria are not susceptible to the main active ingredient of the drug. The main indication for the use of the drug is the manifestation of vital activity and activity in the human body of yeast-like fungi of the genus Candida.

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• Candida, being a conditionally pathogenic fungus, is able to become activated under the influence of provoking factors, both exogenous and endogenous, and begin pathogenic activity, leading to the development of a specific negative process known as candidiasis. This process extends in the body to the mucous membranes and epidermis, and the localization of the fungal infection may depend on the age or sex differences of a particular patient. Nystatin is used to suppress the vital activity and activity of the fungus, regardless of its location and prevents the occurrence of negative consequences that develop during the period of its pathogenic productivity. Tablets with the active ingredient nystatin show their specific action and suppress candidiasis in the places of their development:
• on the mucosa of the gastrointestinal tract;
• in oral cavity(mucosa, gums, palate and tongue);
• in reproductive system women;
• in genitourinary system men;
• with the development of candidiasis from prolonged antibiotic therapy;
• to prevent the development of candidiasis during operations in the intestinal cavity;
• to prevent the occurrence of fungal infections in people with weakened immune systems or autoimmune diseases.

Release of drugs with active active substance nystatin, a polyene antibiotic, is produced in several dosage forms for use at the site of local damage, in hard-to-reach or inconvenient places. Candles with nystatin are no less common than the tablet form and are often used in gynecology and proctology.

Nystatin tablets: instructions for use

The connection of a polyene antibiotic with complex sterol molecules in the composition of mycosis cell membranes leads to double effect: in a low concentration, the drug is able to suppress the activity of reproduction of a pathogenic agent, in large concentrations, to stop the vital activity of the fungus. The destruction of cell membranes leads to the rapid elimination of candidal foci, if the dosage of the tablets is selected correctly, and the application is carried out for the required period.

How to take Nystatin for thrush, oral candidiasis or proctological dislocation, the attending physician decides. Dosage is dictated by the degree of spread of infection, sexual or age characteristics patient, localization of the lesion.

Nystatin tablets for thrush: application

How to take the drug, the gynecologist or urologist decides. Tablets are taken 6-8 times a day and amount to a total of 250 thousand units of the active active substance, but it has many contraindications and side effects.

As a rule, the course of treatment is from ten days to two weeks, it all depends on the severity pathological process and body resistance. In general, according to experts, a large role in the development of candidiasis is played by the condition immune system.

The doctor prescribes pills for the treatment and prevention of candidiasis. Usually, the drug is prescribed in a course that can last an average of 10-14 days, the period largely depends on how much the pathology has developed and how the body is able to cope with it. It has now been established that the appearance of thrush has a state of immunity.

People with weak immunity are most at risk, therefore, along with the main treatment, doctors recommend taking vitamin complexes to strengthen the body's resistance.

The drug for adults is prescribed by a doctor for 250,000 units. per day, reception is recommended from 6 to 8 times. The dosage of the drug may be increased in severe disease, but the daily dose should not exceed 6 million units. Due to the ability to destroy the cell membranes of mycotic infections, the drug has a consistently positive result.

With a recurring disease, the course of treatment is prescribed again, after 2-3 weeks. If there are lesions on the mucous membrane of the gastrointestinal tract, the tablet is dissolved in the mouth and swallowed immediately with enough water.

For the treatment of men in medical practice, tablets are used in combination with nystatin ointment, it is treated with the head of the penis and foreskin. The dose is selected individually by the doctor, depending on the course of the disease.

Nystatin during pregnancy

During pregnancy, lactation and postpartum period Nystatin is usually refrained from prescribing, recommending Pimafucin as less harmless, despite the fact that clinical researches did not reveal a teratogenic effect in nystatin.

Nystatin tablets for children

The dosage of Nystatin for children under one year is not recommended, however, in case of severe lesions, everything can be used and should not be more than 125,000 IU. The drug can be used for internal and external use, if you need a quick and effective effect. The suspension is prepared in this way: the granules are dissolved in a small amount of water (milk) so that the child then drinks. The drug in tablet form is prescribed infrequently, but if necessary, use a ¼ tablet, after which it is not recommended to feed or water the child for 30 minutes. How to take Nystatin age category, it is better to consult with the pediatrician.

Nystatin for stomatitis

In childhood, an aqueous solution of 1 tablet of Nystatin, crushed into powder and mixed and mixed, is used to treat stomatitis. oil solution vitamin B12. After the mixture is brought to the state of a homogeneous substance, the oral cavity is treated with it, and this procedure is carried out at least 3 times a day.

Nystatin: contraindications

An obstacle to the use of the drug may be the presence of individual resistance to nystatin or auxiliary components in the dosage form. The possibility of using Nystatin during gestation or lactation, it is preferable to use another medicine. In the choice between, Nystatin or Fluconazole, which is better to use during pregnancy - Fluconazole: it belongs to triazoles and has a selective effect on the pathogenic agent, unlike Nystatin, which belongs to antibiotics. Pathologies of the gastrointestinal tract and the hepatobiliary system (pancreatitis and liver failure) are also considered contraindications.

Side effects

Possible bitter taste in the mouth, irritation of the vagina or intestines, skin reactions - itching, rash or hives, intestinal disorders or nausea and vomiting.

Overdose

An overdose is characterized by increased side effects or the occurrence of a feverish state, although cases of overdose with Nystatin have not been registered.

Nystatin: analogues of the drug

Azicine, Vilprafen, Pimafucin, Monural, Fluconazole - with another active active substance, but similar in effect.

Compatibility with other drugs

Price

In the prevalence that Nystatin has acquired, cost is of no small importance. How much Nystatin costs, tablets or suppositories, may depend on the region of residence, the packaging of the drug and the network of retail pharmacies. Nystatin, instructions for using the tablet, the price can start from 28 r in Moscow and depend on the manufacturer of the drug.

The share of newborns accounts for many diseases, and thrush is no exception. On the contrary, this disease is increasingly overtaking small crumbs, as a result they cannot sleep peacefully and eat normally without pain, they are constantly naughty and cry.

Who is the thrush provocateur?

Candidiasis is caused by a yeast-like fungus present in the composition normal microflora every person: be it a baby, a woman or an adult man. Candida albicans lives on both the skin and mucous membranes. When creating good conditions for the life of conditionally pathogenic microorganisms, they begin to multiply, which has an extremely negative effect on the well-being of the baby, on the condition of the mucous membranes or skin.

A very popular drug that kills the fungus on the mucous membranes of babies is Nistitin. The crumbs are not able to swallow pills, so doctors advise resorting to a different method of taking this drug. You need to use vitamin B 12 (in ampoules), take a Nystatin tablet and turn it into powder by grinding.

(Note: in the absence of a vitamin, you can resort to boiled water). The crushed tablet should be dissolved in the contents of the ampoule. How to use this solution? It is used twice a day. Take a cotton swab and gently lubricate the areas affected by the fungus. Nystatin is very well tolerated by infants, there are no side effects. For this reason, this medicine is constantly recommended by doctors.

How to recognize thrush in infants?

Moms and caring dads should look at least a couple of times in the child's mouth during the day. Before reaching the age of six months, thrush becomes almost a native disease of babies, that is, it overtakes them quite often. The most popular type of thrush is oral thrush. In this case, the child has the appearance of white spots, similar to cottage cheese in the following places:

• from inside the cheeks;
• crumbs on the gums and lips.

Also, with candidiasis in babies, you can observe the appearance of cracks in the corners of the mouth. Now let's discuss the secondary symptoms of such a sensational disease. Candidiasis formations (spots) burn and cause pain to the baby. These plaques can even bleed. With thrush in children in large quantities saliva is released. In general, any symptom of the disease negatively affects the general well-being.

So, in the presence of candidiasis (thrush), if you remove the formed plaque, you can see an inflamed and swollen area, painted red. If there are no changes, rejoice, as this is not a thrush! Perhaps the spots that have formed are the remaining milk or a simple white coating.

How can a baby pass the infection on to his mother?

It turns out that breastfeeding is dangerous for mothers of small crumbs. What is it expressed in? The danger is that the baby consumes milk from the mother's breast, being sick with candidiasis, can easily transmit the infection. Infection occurs through nipple. Let's look at how thrush manifests itself on the breasts of nursing mothers. Firstly, the feeding process itself is unpleasant and painful, there is a burning sensation and itching. Secondly, the skin becomes a little swollen, and the nipple halo becomes reddish.

Why does thrush (candidiasis) appear in infants?

We have been discussing the disease itself for a long time and will not reach the causes of candidiasis. Which leads to an increase in yeast fungus genus Candida?

1. The baby is able to catch thrush while still in the womb. In the case of the appearance of thrush in a woman during pregnancy (it happens very often), the probability of rewarding the child with an infection is very high. Especially the likelihood increases in the absence of treatment. During childbirth, or rather passing through birth canal, the fungus will not be difficult to hit the baby and start its breeding path in any of its mucous membranes or on the skin. The oral mucosa is more commonly affected.
2. A disease such as candidiasis requires strict adherence to hygiene standards. It is not uncommon to notice that hygiene is neglected or maintained at a low level by employees. maternity hospital. Here's your direct route to infection.
3. Hygiene should be monitored by parents, in particular mothers of babies, as they constantly feed them, play, spend most time. Therefore, the recommendation will be as follows: do not give dirty nipples, rattles and any other items, toys, exclude non-sterile bottles for food. After all, it is the non-compliance with the usual hygiene standards that leads to the formation of a favorable environment for the development and good life of the fungus in the oral cavity of your child.
4. Breastfeeding is of great importance. When purchasing juices, food for babies, water in stores or pharmacies, due attention should be paid to the amount of sugar present in them. In order to avoid the development of candidiasis, do not feed children with very sweet similar foods.
5. Long-term antibiotic therapy. Thrush can overtake a baby not only when he takes these drugs. Also, the infection can be transmitted from a mother who takes antibiotics (infection occurs during breastfeeding). Why are antibiotics harmful? Their negative impact is caused by the destruction of not only harmful bacteria, but also beneficial ones. Beneficial bacteria exercise control and prevent Candida yeast-like fungi from multiplying rapidly and forming so-called infectious colonies.
6. In general, thrush occurs due to the weakened immune system of the newborn. Lead to weak immunity various diseases, colds etc. Now mothers, being familiar with the causes of this disease in babies, should try to do everything in their power to prevent the development of opportunistic microorganisms (fungi) in small children.

How to treat thrush in infants?

Initially, I would like to mention the danger of self-treatment, which can lead to unclear consequences. Therefore, to start therapy, you should consult a doctor. Infants for the treatment of affected areas are prescribed anti-fungal agents (for example, a solution, an ointment). It is also necessary to treat mothers who breastfeed their babies to avoid the possible reproduction of a fungal infection.

If a medical therapy will be carried out correctly and properly, immunity will be well developed until the baby reaches 6 months, candidiasis will pass and will no longer bother (true, if good conditions for fungal growth). At improper treatment and lack positive results, you need to examine the baby-baby in full.

We treat thrush with drugs from a pharmacy

An effective remedy for fighting fungi is Candide in the form of a solution. It is used to treat the mucous membranes of babies affected by Candida. How to use this tool? Take a cotton swab and soak it in the purchased solution. Then proceed to wiping the affected mucous membranes, where you can see the formed plaque in the form of cottage cheese. Maximum amount procedures per day - four. If we talk about improvements, they are observed after about 3 days of therapy.

An excellent drug in order to cure the disease is Nystatin from, and in children belonging to the older age category. Correct Application tablets for babies were considered at the beginning of the material presented. Now consider the use of nystatin drops.

Drops are used in the amount of one milliliter for each side of your baby's mouth. To lubricate the oral mucosa, you can take not only a cotton swab. For these purposes, a cotton swab or, for example, a sterile bandage is suitable. How long the treatment with nystatin drops will last, only your doctor will tell you.

Often optimal time therapy against thrush - ten days. I would like to note that Nystatin destroys precisely fungal infection, in no way the absorption of the drug can not be carried out. If we talk about oral administration, doctors advise taking a quarter of Nystatin in tablets. Only one rule must be followed: feeding and drinking should be carried out after 30 minutes after taking the drug.

Good results in the treatment are shown by the use of an agent based on methylthioninium chloride. Its name is blue. This drug has an effect both antiseptic and disinfecting, that is, it fights the fungus and kills it. Treatment with bluing will allow you to observe improvements after three days. Now let's discuss its application. As with other drugs, it is recommended to use cotton swab. When processing, you need to be as careful as possible - do not press hard on the stick used. The procedure should be carried out after breastfeeding, after three hours. The maximum number of such procedures per day is 6 times.

Does Zelenka help in the treatment of thrush?

Yes, brilliant green is also used in the treatment of candidiasis, as it helps to suppress the colonies of the fungus of the genus Candida. AT pure form this remedy must not be applied to the mucous membrane of the oral cavity. Why? Because it contains alcohol. As you know, alcohol can negatively affect the mucous membrane - that is, lead to the formation of a burn. Therefore, it can be used only after diluting it with water and hydrogen peroxide. The required proportions are as follows: water and hydrogen peroxide are taken one teaspoon each, the number of drops of brilliant green is five.

We treat thrush with folk remedies

Often, in the treatment of thrush in children (including infants), they resort to folk and uncomplicated remedies. One of those is soda solution. Its preparation is very simple: take warm water in the amount of 200 ml and add 1 tsp to it. soda. To carry out wiping the oral cavity, it is necessary to moisten a swab in the resulting solution either from gauze or from cotton wool. How often should a child's mouth be treated? The procedure is repeated quite often, every 2 hours. Let's say your baby is naughty and refuses to carry out such rubbing, what to do in such a situation? Take a nipple, soak it in a baking soda solution and place it in the baby's mouth.

A good remedy for candidiasis is the mood of calendula. For cooking, take boiling water - 200 ml and chopped calendula flowers - 1 tsp. The components are mixed and infused for about an hour. Attention! Do not forget to cover the container with the infusion! Use a towel to cover. It is important to know that you will constantly have to prepare the tincture again. The remaining infusion is perfect for rinsing your mouth (it is an excellent disinfectant).

In the absence of an allergic reaction, such a delicious delicacy as honey acts as a permitted and recommended remedy. More specifically, a honey-based solution is used. To prepare it, you need to combine water and honey in equal proportions, and then use a water bath to heat the resulting mass. Then they take a bandage, wrap a finger around it and dip it into the solution. Next, a moistened finger is used to treat the oral cavity.

Prevention of thrush for babies

As for the very period of pregnancy, women, having discovered thrush, should immediately resort to treatment (but not to self-medication), but not let it take its course. Since, as mentioned above, infection of the baby can occur extremely quickly and easily.

IMPORTANT! No need to resort to the use of drugs and other methods of treatment without a doctor's prescription. For the sake of the health of the child and your health, you need to go to the hospital, see a specialist who will find individual approach to each and will advise the correct therapy.
I really want neither you nor your baby to overtake such ailments!

If you have any questions regarding such a popular disease as thrush, consult our doctor right now!

The modern pharmaceutical industry offers the buyer a wide selection of medicines for thrush, Nystatin tablets are one of effective drugs belonging to the group of antifungal drugs. What made the drug so popular and positive reviews from leading experts? Let's try to figure it out.

Action of Nystatin

The tool has a wide spectrum of action and is effective not only for vaginal fungal infections, but also for candidiasis, intestines and skin. A feature of Nystatin is that it is not absorbed into circulatory system, but acts directly in the inflammatory focus.

When taken orally, the drug is excreted practically unchanged. One of the important advantages of the drug is that it does not affect the useful bacterial microflora, and its action is selective.

The principle of action of nystatin is based on the possibility of penetration into the cells of a fungal infection. As a result of such penetration, the cell membrane is destroyed and the pathogenic microorganism is destroyed.

With candidiasis, the remedy can be prescribed in the form of tablets and ointments. Each of these dosage forms has its own characteristics. Let's talk about the benefits and principle of action of tablets.

How to take Nystatin for thrush?

Nystatin tablets are antibacterial agent, which belongs to the group of polyenes. The medicine has a yellow color and a protective shell. The use of the drug does not depend on meals.

Experts prescribe the drug not only as a treatment for candidiasis, but also for purposes.

As a rule, the course of treatment is from ten days to two weeks, it all depends on the severity of the pathological process and the resistance of the organism itself. In general, according to experts, the state of the immune system plays an important role in the development of candidiasis.

People with a weakened immune system are at risk. That is why, along with the main treatment, it is important to take multivitamins to strengthen defensive forces organism.

• For adults, the doctor prescribes 250,000 IU of the drug per day. The number of receptions varies from six to eight times. In severe cases, the amount of the drug is increased, but daily dosage in no case can it be higher than 6 million units.
• children under one year of age, the dose of nystatin should not exceed 125,000 units. Nystatin granules can be used in the treatment of children for both internal and external use. In order to prepare the suspension, the granules are diluted with a little chilled water or milk, and then given to the child to drink.

With recurrent forms of candidiasis, the course of treatment may be repeated after two to three weeks. If the lesion has affected the mucous membranes of the digestive tract, then, depending on the site of the lesion, the tablet is either simply placed in the oral cavity for resorption, or swallowed immediately.

The tablet should be placed in the oral cavity with lesions of the mucous membranes or swallowed with water, with lesions of the digestive tract.

As for the treatment of men, the intake of tablets must be combined with nystatin ointment, which is rubbed into the glans penis and foreskin. The dosage depending on the type of candidiasis is selected individually by the doctor.

Instructions for use

Before proceeding with treatment, it is important to carefully study, which contains important information regarding dosages, duration of treatment, as well as possible side effects and contraindications.

Indications and contraindications

The drug is prescribed in the following cases:

• with a long antibiotic therapy to avoid the development of candidiasis;
• after surgery;
• treatment of all types of fungal infection.

The drug has its limitations and it should not be used categorically in the following cases:

• period of pregnancy;
• lactation;
• ulcer;
• inflammation of the pancreas acute phase development;
• allergic reactions;
• severe liver disorders.

Separately, I would like to say about pregnant women, although the period of bearing a child is considered a contraindication to the use of the drug, yet some experts prescribe medicinal product even during this period.

This is done in forced cases, when it is simply impossible to do without the drug and the expected benefit is much higher than possible harm for fetal development. During pregnancy, the dosage of tablets is reduced to a minimum, but the final decision is made by the doctor.

If we talk about a safe method, then for pregnancy the only safe dosage form is nystatin ointment, which only affects the skin and mucous membranes, and cannot harm the development of the child.

Side effects

Nystatin is well tolerated by patients, but in some cases, unpleasant side effects may appear, namely:

• nausea, vomiting;
• pain in the abdomen;
• diarrhea;
• allergic reactions in the form skin rashes, itching;
• chills, fever.

With prolonged use of Nystatin, the development of resistance of a fungal infection to the action of the drug is possible. As a result, such treatment will be ineffective.

If side effects occur, you should stop taking the drug and consult a doctor for further adjustment of treatment.

Conclusion

Although there are those who doubt the effectiveness of nystatin, due to the emergence of newer drugs, this drug still shows its worth and is used in the treatment of women, men and children. The price cannot but please, which, depending on the area, can vary between 20-40 rubles per package.

So, nystatin tablets will help you quickly and effectively get rid of thrush. Is it possible to combine an affordable price, high efficiency and reliability?

Release form

Nystatin is produced by many Russian pharmaceutical companies in the following forms:

• Coated tablets. One pack of such Nystatin contains 10-20 small round yellow-greenish tablets that have the smell of vanillin.
• Rectal suppositories. They have a torpedo shape and a yellow tint, and one package includes 10 suppositories in blisters of 5 pieces.
• Vaginal suppositories. They are also sold 10 pieces per pack, have an elongated shape and yellow color.
• Ointment. Such Nystatin is represented by a yellow thick mass placed in aluminum tubes of 15, 25 or 30 grams.

In drops, capsules, ampoules for injections, suspensions and other forms, Nystatin is not available.

Compound

All variants of the drug contain nystatin as the main ingredient, the amount of which is measured in active units. One tablet, one rectal suppository or one vaginal suppository contains 250 or 500 thousand units, and the dosage of such a substance in one gram of ointment is 100,000 units.

Additionally, the tablet form of Nystatin includes magnesium carbonate, hydroxypropyl methylcellulose, potato starch, vanillin, tween 80, lactose, Vaseline oil and some other connections. As part of suppositories (both vaginal and rectal), in addition to nystatin, there are lemon acid, witepsol, vaseline oil and other components for the convenience of using this form. Auxiliary ingredients of Nystatin ointment are only petrolatum and lanolin.

Operating principle

Nystatin has the ability to destroy fungal cells because its structure includes double bonds that make it similar to cell membranes. Thanks to such bonds, nystatin molecules are embedded in membranes and form many channels in them through which electrolytes, water and other substances pass. As a result, the fungal cell becomes vulnerable to osmotic external influence which leads to her death.

Nystatin has shown to be effective against yeast-like and yeast fungi (especially candida), as well as aspergillus. The drug copes well with lesions of the intestines, skin, oral cavity or vagina, affecting fungi locally. At the same time, the treatment does not impair the composition of the normal flora in the intestine.

Orally administered nystatin is not absorbed into digestive tract and is excreted in the feces, practically unchanged. With external processing, the drug is also not absorbed. Tolerance to the drug in susceptible fungi develops slowly. However, the drug does not affect protozoa and bacteria (in particular, it is ineffective against gardnerel and Trichomonas), as well as viruses.

Indications

Nystatin is used in the treatment of candidiasis of the skin, mucous membranes, intestines or internal organs. In addition, the drug can be prescribed for prophylactic purposes, for example, with long-term antibiotic therapy.

From what age is it used in the treatment of children?

There are no restrictions on use in childhood in the instructions for preparations, but only a doctor should prescribe Nystatin to children, and preferably after determining the sensitivity of fungi to its active ingredient.

Contraindications

Treatment with Nystatin is prohibited:

• With hypersensitivity to any component of the selected form.
• With ulcerative lesions of the duodenum or stomach.
• With pancreatitis.
• For problems with the liver.

Side effects

Nystatin tablets may cause nausea, loose stools, or vomiting. The medicine in any form can provoke an allergic reaction, for example, itching of the skin. In such a situation, the drug is canceled and another antifungal agent is selected.

Very long-term use can lead to the development of resistance of fungal cells, due to which it is necessary to prescribe another therapy.

Instructions for use

The form of Nystatin is chosen depending on the reason for which the drug is prescribed. For example, if a medicine is needed to prevent candidiasis due to long-term use of an antibiotic, then it is prescribed in tablets. The tablet form is also used for candida lesions of internal organs.

If a child has candidiasis of the skin or mucous membranes, it is more convenient to use the ointment. Rectal suppositories are preferred when diagnosing fungal infections of the intestine. For thrush in the mouth, a powdered tablet can be mixed with a solution of vitamin B12 or water and lubricated with infected areas.

Nystatin tablets are taken regardless of the diet, and the frequency of administration and daily dose depend on age:

• Children 1-3 years old the medication is given 1 tablet of 250,000 units three times or four times a day.
• For a child over 3 years old a single dosage is 250-500 thousand units, and the frequency of taking tablets is 4 times a day.
• Babies up to a year the drug is prescribed in a dose of 100-125 thousand units and given under the supervision of a physician.

It is advisable to swallow the medicine without biting or chewing, but for small children it is acceptable to crush the tablet, and with oral candidiasis, you can dissolve the drug behind the cheek. The duration of treatment with the solid form is usually 10 to 14 days.

If required, after 7 days, a second course is prescribed.

If the child was prescribed Nystatin in ointment, then a thin layer of such a medicine is smeared with a candida-affected area twice a day. The treatment is carried out for 7-10 days and, if necessary, supplemented with medication in tablets. Nystatin in rectal suppositories for 10-14 days is administered one suppository into the rectum in the morning and evening.

Overdose

Since the main component of Nystatin acts only locally, and is not absorbed when it enters the intestine, the drug is classified as low-toxic, and cases of its overdose have not yet been registered.

Interaction with other drugs

Simultaneous treatment with Nystatin and any of the clotrimazole preparations is not recommended, since the effectiveness of these antifungal drugs in such a combination decreases.

Also, do not combine the reception of Nystatin and indirect anticoagulants, antacids, polymyxin, retinol and some other means.

Terms of sale

All forms of Nystatin are prescription drugs. average price packaging of rectal suppositories is 60 rubles, for a tube with 30 g of ointment you need to pay about 70-80 rubles, and approximate cost 20 tablets - 35-40 rubles.

Storage conditions

About the treatment of children with Nystatin meet different reviews. In some, the medicine is praised and noted that it helped get rid of candidiasis. In others, the drug is called outdated and ineffective, and the tablet form is inconvenient to use. Doctors consider the drug effective and prescribe if the pathogen is sensitive to it. Judging by the reviews, the tolerability of Nystatin is generally good, and negative effects are rare.

Analogues

Nystatin can be replaced by something else antifungal medicine. The doctor may recommend:

• Candide. Such a drug is produced in the form of a solution, cream, gel, powder and vaginal tablets. Its action is provided by clotrimazole. The drug is used at any age.
• Fluconazole. This antifungal capsule or injection is often prescribed to prevent complications during antibiotic treatment. It can be given to children from 4 years of age.

• Pimafucin. The basis of such tablets, suppositories and cream is natamycin. The drug can be prescribed for a fungal infection at any age.
• Diflucan. This fluconazole-based suspension can be used for candidal stomatitis in a child from birth.

In addition, with the defeat of candida in the oral cavity, children can be prescribed such local funds as a gel, solution, extract or spray, as Stomatidine, Geksoral, Oralsept, Tantum Verde, Holisal, Stomatofit other. Lubrication of wounds or irrigation of the throat with these drugs helps to eliminate inflammatory process, reduces soreness and promotes the fight against fungi.

Waiting for you in the next video detailed review doctor about this drug.

Drug Nystatin

Nystatin belongs to the group

antifungal drugs and is used to treat

candidiasis

Release form

Instructions for use NystatinIndications for use

Contraindications

• pregnancy;
• the period of breastfeeding;
• pancreatitis;
• peptic ulcer;

Side effects

When such

symptoms

Treatment with Nystatin How to take Nystatin?

Dosage

Nystatin for children

Nystatin during pregnancy

pregnancy

PimafucinPolygynax

Difluzol, etc.).

Nystatin for thrush

thrush

Reviews about the drug

The price of the drug

Drug Nystatin

Nystatin belongs to the group

antifungal drugs and is used to treat

candidiasis

Caused by fungi of the genus Candida and Aspergillus. This drug can be used to treat candidiasis of the oral cavity, skin, vagina and intestines, because it is not absorbed into the blood and acts on the fungus locally. Nystatin has no effect on the normal bacterial flora. When taken orally, it is excreted from the body in an almost unchanged form along with feces.

Nystatin acts destructively on cell membranes fungi and, penetrating into the cell, causes its suppression or death. It can be used for a long time, because fungi do not develop resistance to it for a long time. The drug is available in various pharmacological forms and, due to its low toxicity and effectiveness, it can be used among almost all groups of patients, excluding pregnant women and individuals with individual intolerance to this drug.

Release form

Nystatin is available in various forms:

• tablets - 250 and 500 thousand units, 10 pieces in a blister, 20 pieces in a package;
• granules for the preparation of a suspension (Fungostatin) - 100 thousand units in 1 granule, 7.5 g in a vial;
• ointment - 100 thousand units per 1 g, 15 or 30 g in tubes;
• rectal suppositories - 500 thousand units, 10 pcs. packaged;
• vaginal suppositories - 250 or 500 thousand units, 10 pieces per pack.

Nystatin granules and tablets can be used to treat or prevent fungal infections caused by various reasons. Granules are convenient to use for the preparation of suspensions for children. Tablets can be used for the preparation of a solution of Nystatin, and for oral administration.

Rectal and vaginal suppositories include, in addition to Nystatin, a number of additional substances that make it more convenient for the treatment of candidiasis of the vagina and lower intestines. Suppositories should be administered after the toilet of the perineal area, following all the doctor's recommendations.

Nystatin ointment for external use is used to treat skin candidiasis. In addition to Nystatin, its composition includes components such as white petrolatum and lanolin, which provide uniform distribution active substance. If necessary, this ointment can be used not only for the treatment of skin candidiasis, but also for the treatment of candidiasis of the vulva and anus.

Application instruction of Nystatin

Indications for use

• Prevention of candidiasis long-term treatment antibiotics;
• prevention of intestinal candidiasis in the preoperative period and after surgical operations;
• prevention of candidiasis of the external genital organs with the external use of antibacterial drugs;
• treatment of candidiasis of the vagina or organs of the gastrointestinal tract;
• treatment of candidiasis of the skin or mucous membranes.

Contraindications

• pregnancy;
• the period of breastfeeding;
• pancreatitis;
• peptic ulcer;
• severe violations in the functions of the liver;
• hypersensitivity to Nystatin.

Side effects

• when taken orally and with the introduction of rectal suppositories - nausea, vomiting (sometimes), diarrhea, discomfort and abdominal pain;
• when using vaginal suppositories - allergic reactions are possible;
• with prolonged use - in rare cases, the development of resistance of fungi to the drug and the lack of its effectiveness are possible;
• when taken orally in any form, allergic reactions are possible (fever, chills, pruritus, rash).

When such

symptoms

withdrawal of the drug and its replacement with another antifungal agent is required. Side effects when using Nystatin are quite rare and easily reversible.

Treatment with Nystatin

How to take Nystatin? Nystatin tablets can be taken with or without food. It is recommended to swallow them whole (not crushed or chewed). Average duration The treatment course is about 10 days or 2 weeks.

In some cases, with candidiasis of the oral mucosa, Nystatin tablets can be administered as follows: a tablet of 500 thousand units is placed behind the cheek until completely absorbed. It is recommended to take after meals and oral hygiene 3 to 5 times a day.

In the event that the patient suffers from generalized or constantly recurring forms of a fungal infection, repeated courses of Nystatin can be repeated at intervals of 2-3 weeks.

Nystatin granules (syn. Fungostatin) can be used for internal and external use in the treatment of candidiasis in children. When preparing a suspension for oral administration required amount granules are diluted in a small amount of chilled boiled water or milk. The resulting suspension is given to drink to the child.

If it is necessary to prepare a suspension for external use, it is necessary to dissolve 2 granules in 200 ml of boiled water. Such a solution is used for rinsing the mouth or treating the anus or external genitalia.

Suppositories are inserted into the vagina or rectum 2 times a day (after hand hygiene and external genitalia), and the duration of treatment for such forms of candidiasis lasts from 10 to 14 days.

If it is necessary to treat candidiasis of the skin or mucous membranes, an ointment with Nystatin is used, which can be administered either alone or in combination with taking the tablet form of the drug. The ointment is applied in a thin layer to the areas affected by candidiasis 2 times a day. The duration of treatment is determined by the doctor and, as a rule, is 7-10 days.

Dosage

• Tablets for adults - 250 thousand units 6-8 times a day or 500 thousand units 3-4 times a day (if necessary, during the treatment of generalized candidiasis, the dose may be increased by 2 times).
• Suppositories rectal or vaginal - 250 or 500 thousand units 2 times a day in the morning and evening.
• The ointment is applied in a thin layer 2 times a day on the skin area affected by fungi.

Nystatin: instructions for use - video

Nystatin for children

Nystatin is still used in pediatric practice in the treatment of candidiasis in children. Due to the fact that this drug, when applied externally, is practically not absorbed into the blood, it is quite effective and harmless for the treatment of children.

The external use of Nystatin for the treatment of candidiasis of the skin and mucous membranes (thrush) is widely used, since children quite often get sick with these fungal diseases. For the treatment of skin candidiasis in children, an ointment or self-prepared suspension of Nystatin from granules or tablets (250 thousand units per 200 ml of boiled water at room temperature) can be used.

Some pediatricians recommend using the following composition based on Nystatin for the treatment of oral thrush: powder from a crushed tablet (250 thousand units) is mixed with 1 ml of a solution from an ampoule with vitamin B12. This solution can lubricate the affected areas of the oral cavity. If necessary, the ampoule solution of vitamin B12 can be replaced with water.

The dosage of Nystatin for children when administered orally depends on the age of the child:

• children under one year - 100 or 125 thousand units 3-4 times a day;
• from a year to 3 years - 250 thousand units 3-4 times a day;
• from 3 to 13 years - 250 or 400 thousand units 3-4 times a day;
• over 13 years old - 250 or 500 thousand units 3-4 times a day.

For ease of dosing, not tablets, but Nystatin granules can be used. Dosing during their use is carried out as follows: one granule contains 100 thousand units of Nystatin, age dosage at one time, divide by 100 and get the number of granules that must be given to the child.

Nystatin during pregnancy

AT last years Nystatin is rarely given to women during

pregnancy

This drug is contraindicated for use in pregnant women according to the instructions and, due to the availability of a wide range of other antifungal agents, can be successfully replaced by safer antifungal drugs (for example,

PimafucinPolygynax

Difluzol, etc.).

Rarely, nystatin tablets or vaginal suppositories prescribed to pregnant women, but in these forced cases, its dosage is reduced.

The only safe method of treatment with Nystatin during pregnancy can only be considered the use of an ointment based on this drug. When applied externally to treat candidiasis of the mucous membranes or skin, it is not absorbed into the bloodstream and cannot harm the unborn child.

Nystatin for thrush

thrush

(vaginal candidiasis) Nystatin is used in the form of suppositories, ointments and tablets.

Nystatin suppositories allow you to achieve a local effect on the affected area. This form of the drug can only be prescribed by a doctor after an analysis such as a bacteriological smear.

Before the introduction of the suppository, the woman should hold the toilet of the external genital organs and insert the Nystatin suppository into the vagina with clean hands.

As a rule, suppositories of 500 thousand units are prescribed for the treatment of thrush, but in some cases a dosage of 250 thousand units may be prescribed. Candles are recommended to be administered twice a day: in the morning and in the evening. The course of treatment is usually about two weeks, but in some cases, the duration of Nystatin use may increase. Suppositories should not be used during menstruation and during pregnancy and lactation.

Gynecologists in the treatment of thrush often prescribe, together with the use of suppositories, an ointment based on Nystatin, which must be applied 2 times a day after the administration of the suppository. The course of its application can last from several days to two weeks, and with chronic form thrush may be given a second course of treatment after three weeks.

It is advisable to conduct parallel treatment of the sexual partner with nystatin ointment, which in these cases is applied to the glans penis twice a day. This measure is explained by the fact that, despite the lack of clinical manifestations thrush, a man may be a carrier of the fungus of the genus Candida, and sexual intercourse with him after treatment of the disease may provoke a relapse of the disease.

In some cases, to treat thrush that develops against a background of long-term illness or treatment antibacterial drugs, Nystatin tablets are used. The dosage of the drug is carried out according to the age of the patient, and the duration of treatment is determined by the doctor.

In recent years, Nystatin has been used less frequently for the treatment of thrush, since the modern pharmacological industry produces a large number of other antifungal drugs (Levorin, Betadine, Clotrimazole, Terzhinan, etc.), which are more convenient to use. Despite this, in some special clinical cases, gynecologists appoint Nystatin. As a rule, this drug is well tolerated by patients and rarely causes adverse reactions.

Interaction of Nystatin with other drugs

Nystatin interacts with few pharmacological preparations, because it practically “transit” passes through the human body. It is not absorbed and does not accumulate, does not penetrate through the mucous membranes into the blood, and does not go through the process of any biotransformation.

The only exceptions are some drugs with which it can interact and lose its activity or reduce the effectiveness of a particular drug.

• Tetracycline with Nystatin - complement each other well, providing a pronounced antimicrobial and antifungal effect;
• Clotrimazole with Nystatin - the activity of Clotrimazole decreases;
• Polymyxin and Nifuratel - enhance the effect of Nystatin;
• antacids with aluminum, calcium, magnesium (Almagel, Maalox, etc.) - reduce the activity of Nystatin;
• indirect anticoagulants (Warfarin, Acenocoumarol, Fenindione, Coumadin, etc.) - their activity decreases under the influence of Nystatin, an increase in their dosage is required;
• bactericidal antibiotics (penicillins, cephalosporins) - their effectiveness decreases when interacting with Nystatin;
• Chymotrypsin - the effectiveness of Nystatin is enhanced;
• estrogen-containing oral contraceptives (Marvelon, Logest, etc.) - their effectiveness under the influence of Nystatin may decrease, and the risk of breakthrough (intermenstrual) bleeding increases;
• when combined with Nystatin retinol preparations - the risk of increased intracranial pressure increases.

Reviews about the drug

According to the reviews of the majority of patients who took Nystatin in various forms, it is effective only in detecting the sensitivity of fungi of the genus Candida to it. The drug in all forms is well tolerated by patients: only rarely causes allergic reactions and side effects in the form of nausea, indigestion and fever. The use of Nystatin in the form of ointments and suppositories almost never causes local allergic reactions.

Nystatin, based on the reviews of many patients, has a weak effect on the fungal flora, since the resistance of these pathogenic microorganisms to the effects of this drug has increased significantly in recent years.

Some of the patients consider Nystatin an outdated drug and prefer that the doctor prescribe them antifungal agents that do not require such treatment. long-term use and more convenient to take (Fluconazole, Difluzol, Levorin, Pimafucin, etc.).

However, there are also reports of cases where modern drugs were ineffective in the treatment of candidiasis, and it was Nystatin that helped. That is why before using any antifungal agents, you should consult with your doctor about the appropriateness of their use.

The price of the drug

The price of Nystatin in various forms of release depends on various factors: the city or region and the pharmacy that sells the drug, the manufacturer of this drug. That is why before buying this drug, you should check the price in different pharmacies. On average, the price of various dosage forms of Nystatin is as follows:

• tablets of 250 thousand units, 20 pieces per pack - 14-16 rubles;
• tablets 500 thousand units, 20 pieces per pack - 13-30 rubles;
• Fungostatin granules, 100 thousand units, 7.5 g per pack - 400 rubles;
• vaginal suppositories 250 thousand units, 10 pieces per pack - 33-40 rubles;
• vaginal suppositories 500 thousand units, 10 pieces per pack - 42-60 rubles;
• rectal suppositories 500 thousand units, 10 pieces per pack - 47-80 rubles;
• ointment 100 thousand units per 1 g, tube 15 g - 21-48 rubles;
• ointment 100 thousand units per 1 g, tube 30 g - 30-45 rubles.

ATTENTION! The information posted on our site is a reference or popular and is provided to a wide range of readers for discussion. Medicines should only be prescribed qualified specialist based on medical history and diagnostic results.

From stomatitis and thrush in the mouth, Nystatin will help children, relieve inflammation and pain syndrome. The main component of the drug is a component of the polyene group, which acts on fungi. This drug from the group of antibiotics is able to penetrate inside the damaging cell and destroy it. The mechanism of action of nystatin is selective, it acts on cells a certain kind without affecting other "beneficial" microorganisms. According to the instructions, nystatin is not active against actinomycetes, viruses and some bacteria. And most importantly, the medicine is budgetary and the price is low.

Nystatin is used for prophylactic purposes and for the treatment of diseases associated with fungal infections in adults and children.

These include diseases of the digestive system, respiratory, gastrointestinal tract, genital organs, lesions of the mucous layer in the mouth, stomatitis and thrush in children. For prevention unpleasant diseases such as thrush and stomatitis, pay attention to the care of the child's mouth and gums from the first days of life. Many parents forget about it and suffer with the inevitable consequences.

Release form

Nystatin is produced in various forms, depending on the concentration of the active substance and the price. Can be used to treat stomatitis and thrush in children rectal suppositories, which contain a dosage of 300 to 500 thousand units. compound substance. There are 10 or more candles in a set. Remember to use tablets with the same amount of active ingredient in the composition. In a package from 10 to 20 pieces. They are applied as complex therapy during treatment.

For lubrication, an ointment is used, which contains 100 thousand units. and is available in tubes of 15-20 g. Especially convenient is the use of nystatin in the form of drops. They are available in small forms of 5 ml. For the manufacture of solutions, dry powders have been created that are dissolved in water to drink or applied dry. Inside and for rinsing, a suspension of nystatin is used (dosage 200 thousand units).

Instructions for use

For younger children up to a year and after, with thrush and stomatitis in the mouth, it is recommended to use nystatin in the form of drops or an aqueous solution. There is an instruction for preparation: a tablet containing 250 thousand units. crush the active substance with a spoon and dissolve in a glass of water. In such a solution, you can add vitamins to strengthen the baby's immunity. Dip a cotton swab or bandage into it and lubricate the child's mouth 3-4 times a day after meals. Also, children can lubricate sores and lesions with ointment. To treat the cheeks of a baby up to a year, drops are used that gently lubricate the inflamed mucous membrane. We take 1 ml. solution.

An older child is given pills. Doctor counts daily dose medication based on the patient's symptoms. Reception is divided into 3-4 times. Take the tablet after a meal with a glass of water. Or it is placed on the cheek and absorbed. Do not forget about the ointment, which lubricates the wounds in the oral cavity. It is applied to the foci of the spread of infection with cotton pads or gauze. This procedure is done 2-3 times a day after meals.

Nystatin ointment is a good remedy for stomatitis and thrush, which helps to relieve pain and irritation, destroys the fungus.

Do not worry if the ointment gets inside. It will not be absorbed into the walls of the intestine, but will come out naturally. It is possible to use rectal suppositories for the prevention of thrush. They are used as a treatment in conjunction with other drugs for intestinal lesions and pain in children. Candles are administered rectally 1-2 times a day.

Exact dosage:

• Infants under one year old: 100 thousand units. up to 125 thousand units active substance;
• From 1-3 years: 250 thousand units;
• Children under 13 years old: from 250 thousand units. up to 400 thousand units;
• From 14 years old: dosage of 500 thousand units. drug.

The course of treatment for thrush and stomatitis is from 10 to 15 days. The dosage is prescribed only by a doctor!

Contraindications

Contraindications for adults and children are as follows:

• Strong sensitivity to the use of the drug;
• allergic reactions;
• Violation of the liver, kidneys and pancreas;
• stomach ulcer;
• pancreatitis;
• Complete intolerance to the components.

Unauthorized treatment with antibiotics is unacceptable, be sure to consult your doctor!

Side effects

Nystatin is slightly toxic and does no harm. But sometimes it happens side effect on the body, such as:

• Hyperthermia;
• Nausea;
• Liquid stool;
• Removal of vomit;
• Chilled state;
• Pain;
• redness and rash;
• Itching on the body;
• swelling in the mouth area;
• Hyperemia of the mucous membrane.

Before using nystatin for stomatitis and thrush, the instructions should be read and you should be aware of side effects. It is important to know about them if you have a baby under one year old. If your child has any side effects, contact your doctor and stop taking it.

Storage conditions of the drug:

• In a dry place without access to light;
• Tablets can be stored at room temperature;
• Ointment - at 6 ° C;
• Candles - in the refrigerator or a cold place;

Shelf life: tablets, suppositories, suppositories - up to 2 years, ointment - up to 3 years.

Interaction with other drugs

Nystatin wide range interactions with other drugs, so it is necessary to know with which of them joint treatment is possible in order to avoid side effects. Nystatin, when taken with tetracycline, has a positive antifungal effect. It removes the effect of clotrimazole on the body. When taken with nifuratel and polymyxin, the effect of each is doubled. When taking anticoagulants healing effect nystatin is reduced. It reduces the effect of antibacterial drugs on the body.

Analogues

The drug has analogues that contain similar active substance identical effect on the body.

• Amphoglucamine, which has an antifungal effect on the digestive and other internal organs. Active against yeast-like fungi and mycoses. Apply in the form of tablets or suppositories after meals 2 times a day. Time for treatment from a week to 10 days.
• Levorin, whose action is just aimed at the treatment of stomatitis and thrush in children. Used in the treatment of children from 2 years. It is used in the form of tablets, suppositories and ointments.
• Amphotericin B- a non-toxic drug aimed at the destruction of yeast fungi and mycoses. It is prescribed when treatment with other antibiotics has failed. Amphotericin tablets are widely used in medicine as a gentle antibiotic. Solutions are used that are administered by dropper for 5 hours. It is also used in the form of an ointment, for external use in children under one year old. Rectal suppositories are prescribed when treatment of dysbacteriosis and intestinal problems is required.
• Mycoheptin- used to treat visceral mycoses. This drug is moderately toxic, therefore it is used only under the supervision of the attending physician. It controls the amount of creatinine and urea in the blood.

Price

The price of the drug is small and acceptable. Prices vary for different forms.

• Nystatin tablets (500 thousand units), 20 pcs. - 20-25 r;
• Nystatin tablets (250 thousand units), 20 pcs. - 15-20 r;
• Nystatin suppositories (500 thousand units), 10 pcs. - 55 r;
• Nystatin ointment (100-500 thousand units) - 55-85 r;
• Tetracycline with nystatin (100 thousand units) - 85 rubles.

Do not forget to prevent diseases of children in time, do not take them to extreme measures. Be sure to consult with your doctor about taking medications, start treatment in a timely manner and most importantly - be healthy!

The fungistatic agent Nystatin is used for antibiotic therapy of candidiasis - inflammation of the mucous membranes and epidermis due to damage to them by yeast-like fungi.

Available in several dosage forms for internal and local use, namely suppositories, tablets and ointments. It is not absorbed into the bloodstream and is not toxic, therefore it is suitable for the treatment of thrush even in newborns. It is sold in pharmacies at a low price, which makes this effective medicine accessible to all segments of the population.

Nystatin suppositories, tablets, ointment - instructions for use

Despite the fact that the drug has practically no toxic effects on the body, it is an antibiotic and should only be used as directed by a doctor.

First, the specialist will accurately determine the cause of the inflammation, which may not be a fungus, but a bacterial infection.

Secondly, at this medicine there are some restrictions on use that must be considered in order to avoid complications.

Thirdly, a longer course of antibiotic therapy may be needed than indicated in the instructions.

Composition of Nystatin

The active substance is nystatin.

A specific yeast-like fungus of the genus Candida is an integral part of the natural microflora human body. Normal at healthy person its numbers are controlled by bacteria that secrete antibiotic-like substances, so the mucous membranes do not become inflamed. If, under the influence of any factors, the composition of the microflora changes (for example, it partially dies due to systemic therapy with antibacterial drugs), opportunistic pathogens are starting to multiply.

Nystatin is a polyene antibiotic, first isolated in the middle of the last century from the actinomycete Streptomyces noursei.

The mechanism of the fungistatic effect on yeast-like fungi is the incorporation of drug molecules into the cell wall of the pathogen. As a result, its structure is disturbed due to the formation of many channels, changes in osmotic pressure and output internal structures out - that is, the cell is destroyed. In addition to yeast and Candida, Aspergillus spp. are also sensitive to the drug, and bacteria, protozoa and viruses show resistance.

Release form Nystatin

Raw materials for the production of medicines with such trade name is a bitter taste powder and yellow color. It is poorly soluble in water, and its activity is expressed in units of action. Several dosage forms are made from it at pharmaceutical enterprises:

• Tablets for oral administration, containing 250 or 500 thousand units, coated. The forming ingredients in this case are hydroxypropyl methylcellulose, lactose, calcium stearate, titanium dioxide, magnesium carbonate, liquid paraffin, flavor and others. The name Nystatin in the Latin prescription is usually written as Nystatinum.
• Vaginal suppositories (candles for topical use in the vagina), each of which contains 250,000 or 500,000 IU of the active substance. Auxiliary components - ester (propyl) of paraoxybenzoic acid, witepsol H-15 and W-35, citric acid.
• Suppositories for rectal administration in composition and amount of antibiotic are almost identical to vaginal ones. The only difference is the presence of petroleum jelly in them.
• Ointment in tubes of 30 ml, for each gram of which there are 100,000 units of nystatin. excipients here are medical vaseline and anhydrous lanolin. Used externally.

Photo Nystatin tablets 250 000 IU

The tablet form is sold in blisters of 10 pieces or in jars of 20 tablets. Candles are packaged by 5 in contour packs, in total there are 10 suppositories in a pack.

Recipe for Nystatin in Latin

Rp.: Nystatinum 500,000

S. 1 tablet 4 times a day.

What is Nystatin used for?

Due to its fungistatic action, this antibiotic has been successfully used to treat candidiasis, commonly known as "thrush". This disease affects the mucous membranes and epidermis. A pathogenic fungus can multiply in the intestines (tablets and rectal suppositories are used for this form), in the mouth, which is often found in infants, on the skin and in the vagina.

All varieties of the drug act superficially, without being absorbed orally when applied topically (in the gastrointestinal tract it is also absorbed in small quantities). This allows you to act directly on the cause of the infection, with little or no harm to the body. Therefore, Nystatin is also prescribed for children (at a dosage lower than for adults) in the case of thrush, which manifests itself as a white coating in the mouth. In women, when the immune system is weakened or during pregnancy, vaginal candidiasis can develop, which is treated with suppositories.

Indications for use Nystatin in suppositories, tablets and ointments

The drug is prescribed in one or another dosage form according to the localization of the inflammatory process:

• tablets are intended for the treatment of intestinal candidiasis and its prevention in case of long-term use of antibiotics, as well as systemic therapy:
• rectal suppositories are used for fungal infections of the lower parts of the large intestine;
• vaginal suppositories are prescribed for thrush in gynecology;
• ointment is used in the case of a skin variety of the disease.

Like pills, other types of drugs are and prophylactic with antibiotic therapy and in the postoperative period.

Contraindications Nystatin

Like any antibacterial medication, this antibiotic has certain restrictions and restrictions on its use. First of all, you can not use the medicine in any form in the presence of hypersensitivity to the active substance.

Nystatin is also not prescribed during pregnancy, in order to avoid negative impact on the fetus, because with systemic use, the antibiotic still penetrates into the bloodstream. In addition, in the presence of certain pathologies of the digestive system (pancreatitis, peptic ulcer of the duodenum or stomach, liver failure) is also prohibited.

Nystatin during pregnancy and breastfeeding

Many expectant mothers are faced with candidiasis due to inevitable changes. hormonal background. During this period, women should especially monitor their health in order to avoid dangerous diseases and the consequences of their treatment. However, it is necessary to get rid of thrush, because when it vaginal variety except for the discharge appear severe itching and discomfort in the affected area.

Nystatin during pregnancy, according to the instructions for it, is prohibited, but this applies only to the first trimester. Subsequently, you can prescribe a medicine, taking into account the benefits for the woman herself and potential danger for the fetus. During lactation, it is also desirable to temporarily stop breast-feeding. However, for pregnant women there are safe analogues drug, which allows you to get rid of candidiasis without fear for the health of the unborn child.

Dosage of Nystatin for children and adults

When taken orally, the drug in the digestive tract is practically not absorbed, so food intake does not affect the therapeutic effect. The course of antibiotic therapy can last from one to two weeks, depending on the location and severity of the inflammatory process.

The daily dose for Nystatin 500,000 tablets, according to the instructions for their use, with intestinal candidiasis is 2-4 million units, with a generalized variety - 6,000,000 (for adults). A single dose is usually taken 500 thousand units, that is, one or two tablets that need to be washed down with water, at equal intervals of 3-6 hours.

The ointment is applied externally: it is applied in a thin layer to the affected areas of the skin twice a day for a week (sometimes up to 10 days) and is usually combined with systemic therapy with tablets. Suppositories of both types are administered according to the intended purpose (vaginally or rectally) in the morning and evening for the recommended period, most often from 10 days to 2 weeks.

Nystatin tablets for children instructions for use advises dosage according to age. A child from 1 to 3 years old suffering from candidiasis is recommended to give 250,000 IU of the active substance 3 or 4 times daily. For older children, a single dose can be doubled according to indications. The duration of antibiotic therapy averages 10-14 days.

Nystatin - side effects and side effects

Drug therapy with this fungistatic agent most often does not negative impact. However, in rare cases, such responses to an antibiotic are possible from the body, such as:

• allergy in the form of hyperthermia, chills or pruritus;
• dyspeptic phenomena (diarrhea, vomiting or nausea) during treatment with tablets and rectal suppositories;
• accession of a secondary infection caused by resistant species of fungi.

In the event of side effects, treatment should be discontinued, picking up more the right medicine or simply reduce the dose.

Nystatin and alcohol - compatibility

With local or external use of the drug, it does not enter the bloodstream and, accordingly, does not interact with ethanol in the body. However, drinking alcohol is still not recommended, since alcohol affects the metabolism of carbohydrates in the body.

Drinking leads to an increase in the concentration of sugar in the blood, which is a breeding ground for yeast-like fungi. Thus, the effectiveness of antibiotic therapy will decrease. Systemic treatment(tablets) can adversely affect the liver, so alcohol in this case is not combined with an antibiotic.

Analogues

Nystatin tablets are sold under the trade name Nystatin. The drug has no analogues with a similar active substance.

In gynecology, combined candles can be used:

• Nystatin + Nifuratel (Macmirror complex);
• Neomycin + Polymyxin B + Nystatin (Polygynax).